headshot of Delin Shi

Delin Shi

Researcher Graduate Student
delin.shi@pitt.edu
Bioengineering Department

overview

My research interest in Brain-Computer Interface developed during the clinical rotation as an intern doctor. Pioneer BCI studies have demonstrated its potential in neural rehabilitation. But the Foreign Body Response at the Tissue-Electrode Interface remains one of the most challenging obstacles before a chronically stable solution can be applied in clinical neural rehab. My long term goal is to facilitate the translation of Neural Interface research to clinical application.

about

MD, Clinical Medicine, Shanghai Jiao Tong University School of Medicine, 2010 - 2015

MS, Biomedical Engineering, Carnegie Mellon University, 2018

Williams, N.P., Voroslakos, M., Shi, D., Pwint, M.Y., Lanzio, V., Mao, H., Zolotavin, P., Yoon, E., Stieglitz, T., Xie, C., Harris, T.D., Schwartz, A.B., & Cui, X.T. (2025). In vivo microelectrode arrays for neuroscience. NATURE REVIEWS METHODS PRIMERS, 5(1), 31.Springer Nature. doi: 10.1038/s43586-025-00399-7.

Drewry, M.D., Shi, D., Dailey, M.T., Rothermund, K., Trbojevic, S., Almarza, A.J., Cui, X.T., & Syed-Picard, F.N. (2024). Enhancing facial nerve regeneration with scaffold-free conduits engineered using dental pulp stem cells and their endogenous, aligned extracellular matrix. J Neural Eng, 21(5), 056015.IOP Publishing. doi: 10.1088/1741-2552/ad749d.

Shi, D., Narayanan, S., Woeppel, K., & Cui, X.T. (2024). Improving the Biocompatibility and Functionality of Neural Interface Devices with Silica Nanoparticles. Acc Chem Res, 57(12), 1684-1695.American Chemical Society (ACS). doi: 10.1021/acs.accounts.4c00160.

Woeppel, K., Dhawan, V., Shi, D., & Cui, X.T. (2023). Nanotopography-enhanced biomimetic coating maintains bioactivity after weeks of dry storage and improves chronic neural recording. Biomaterials, 302, 122326.Elsevier. doi: 10.1016/j.biomaterials.2023.122326.

Kushwah, N., Woeppel, K., Dhawan, V., Shi, D., & Cui, X.T. (2022). Effects of neuronal cell adhesion molecule L1 and nanoparticle surface modification on microglia. Acta Biomater, 149, 273-286.Elsevier. doi: 10.1016/j.actbio.2022.06.038.

Ahmed, M.N., Shi, D., Dailey, M.T., Rothermund, K., Drewry, M.D., Calabrese, T.C., Cui, X.T., & Syed-Picard, F.N. (2021). Dental Pulp Cell Sheets Enhance Facial Nerve Regeneration via Local Neurotrophic Factor Delivery. Tissue Eng Part A, 27(17-18), 1128-1139.Mary Ann Liebert. doi: 10.1089/ten.TEA.2020.0265.

Shi, D., Dhawan, V., & Cui, X.T. (2021). Bio-integrative design of the neural tissue-device interface. Curr Opin Biotechnol, 72, 54-61.Elsevier. doi: 10.1016/j.copbio.2021.10.003.