Yijen Wu

Cortes, D.R.E., Stapleton, M.C., Schwab, K.E., West, D., Coulson, N.W., O'Donnell, M.G., Powers, R.W., & Wu, Y.L. (2024). Modeling Normal Mouse Uterine Contraction and Placental Perfusion with Non-invasive Longitudinal Dynamic Contrast Enhancement MRI. bioRxiv.Cold Spring Harbor Laboratory. doi: 10.1101/2024.01.31.577398.

Wu, Y.L., Christodoulou, A.G., Beumer, J.H., Rigatti, L.H., Fisher, R., Ross, M., Watkins, S., Cortes, D.R.E., Ruck, C., Manzoor, S., Wyman, S.K., Stapleton, M.C., Goetzman, E., Bharathi, S., Wipf, P., Tan, T., Eiseman, J.L., Christner, S.M., Guo, J., Lo, C.W.Y., Epperly, M.W., & Greenberger, J.S. (2024). Mitigation of Fetal Irradiation Injury from Mid-Gestation Total Body Radiation with Mitochondrial-Targeted GS-Nitroxide JP4-039. bioRxiv.Cold Spring Harbor Laboratory. doi: 10.1101/2024.02.13.580105.

Shang, P., Simpson, J.D., Taylor, G.M., Sutherland, D.M., Welsh, O.L., Aravamudhan, P., Natividade, R.D.S., Schwab, K., Michel, J.J., Poholek, A.C., Wu, Y., Rajasundaram, D., Koehler, M., Alsteens, D., & Dermody, T.S. (2023). Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus. NATURE COMMUNICATIONS, 14(1), 2615.Springer Science and Business Media LLC. doi: 10.1038/s41467-023-38327-6.

Turan, S., Chaillet, J.R., Stapleton, M.C., & Wu, Y.L. (2023). Genome Editing and Myocardial Development. Adv Exp Med Biol, 1396, 53-73.Springer Nature Singapore. doi: 10.1007/978-981-19-5642-3_4.

Carew, N.T., Schmidt, H.M., Yuan, S., Galley, J.C., Hall, R., Altmann, H.M., Hahn, S.A., Miller, M.P., Wood, K.C., Gabris, B., Stapleton, M.C., Hartwick, S., Fazzari, M., Wu, Y.L., Trebak, M., Kaufman, B.A., McTiernan, C.F., Schopfer, F.J., Navas, P., Thibodeau, P.H., McNamara, D.M., Salama, G., & Straub, A.C. (2022). Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death. JOURNAL OF CLINICAL INVESTIGATION, 132(18).American Society for Clinical Investigation. doi: 10.1172/JCI147120.

Han, L., Mich-Basso, J.D., Li, Y., Ammanamanchi, N., Xu, J., Bargaje, A.P., Liu, H., Wu, L., Jeong, J.H., Franks, J., Stolz, D.B., Wu, Y.L., Rajasundaram, D., Liu, Y., & Kuhn, B. (2022). Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts. DEVELOPMENTAL CELL, 57(20), 2397-+.Elsevier BV. doi: 10.1016/j.devcel.2022.09.017.

Chen, A., Jiang, Y., Li, Z., Wu, L., Santiago, U., Zou, H., Cai, C., Sharma, V., Guan, Y., McCarl, L.H., Ma, J., Wu, Y.L., Michel, J., Shi, Y., Konnikova, L., Amankulor, N.M., Zinn, P.O., Kohanbash, G., Agnihotri, S., Lu, S., Lu, X., Sun, D., Gittes, G.K., Wang, Q., Xiao, X., Yimlamai, D., Pollack, I.F., Camacho, C.J., & Hu, B. (2021). Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma. JOURNAL OF CLINICAL INVESTIGATION, 131(16).American Society for Clinical Investigation. doi: 10.1172/JCI147552.

Chiba, T., Cerqueira, D.M., Li, Y., Bodnar, A.J., Mukherjee, E., Pfister, K., Phua, Y.L., Shaikh, K., Sanders, B.T., Hemker, S.L., Pagano, P.J., Wu, Y.L., Ho, J., & Sims-Lucas, S. (2021). Endothelial-Derived miR-17∼92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 32(3), 553-562.Ovid Technologies (Wolters Kluwer Health). doi: 10.1681/ASN.2020050717.

Feldman, K.S., Kim, E., Czachowski, M.J., Wu, Y., Lo, C.W., & Zahid, M. (2021). Differential effect of anesthetics on mucociliary clearance in vivo in mice. SCIENTIFIC REPORTS, 11(1), 4896.Springer Science and Business Media LLC. doi: 10.1038/s41598-021-84605-y.

Gabriel, G.C., Devine, W., Redel, B.K., Whitworth, K.M., Samuel, M., Spate, L.D., Cecil, R.F., Prather, R.S., Wu, Y., Wells, K.D., & Lo, C.W. (2021). Cardiovascular Development and Congenital Heart Disease Modeling in the Pig. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(14), e021631.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/JAHA.121.021631.

Satoh, T., Wang, L., Espinosa-Diez, C., Wang, B., Hahn, S.A., Noda, K., Rochon, E.R., Dent, M.R., Levine, A.R., Baust, J.J., Wyman, S., Wu, Y.L., Triantafyllou, G.A., Tang, Y., Reynolds, M., Shiva, S., St Hilaire, C., Gomez, D., Goncharov, D.A., Goncharova, E.A., Chan, S.Y., Straub, A.C., Lai, Y.C., McTiernan, C.F., & Gladwin, M.T. (2021). Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction. CIRCULATION, 144(8), 615-637.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/CIRCULATIONAHA.121.053889.

Sinsheimer, A., Mohsen, A.W., Bloom, K., Karunanidhi, A., Bharathi, S., Wu, Y.L., Schiff, M., Wang, Y., Goetzman, E.S., Ghaloul-Gonzalez, L., & Vockley, J. (2021). Development and characterization of a mouse model for Acad9 deficiency. MOLECULAR GENETICS AND METABOLISM, 134(1-2), 156-163.Elsevier BV. doi: 10.1016/j.ymgme.2021.09.002.

Teekakirikul, P., Zhu, W., Gabriel, G.C., Young, C.B., Williams, K., Martin, L.J., Hill, J.C., Richards, T., Billaud, M., Phillippi, J.A., Wang, J., Wu, Y., Tan, T., Devine, W., Lin, J.H., Bais, A.S., Klonowski, J., Moreau de Bellaing, A., Saini, A., Wang, M.X., Emerel, L., Salamacha, N., Wyman, S.K., Lee, C., Sing Li, H., Miron, A., Zhang, J., Xing, J., McNamara, D.M., Fung, E., Kirshbom, P., Mahle, W., Kochilas, L.K., He, Y., Garg, V., White, P., McBride, K.L., Benson, D.W., Gleason, T.G., Mital, S., & Lo, C.W. (2021). Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv, 2(3), 100037.Elsevier BV. doi: 10.1016/j.xhgg.2021.100037.

Wu, Y.L. (2021). Cardiac MRI Assessment of Mouse Myocardial Infarction and Regeneration. Methods Mol Biol, 2158, 81-106.Springer US. doi: 10.1007/978-1-0716-0668-1_8.

Airik, M., Schuler, M., McCourt, B., Weiss, A.C., Herdman, N., Ludtke, T.H., Widmeier, E., Stolz, D.B., Nejak-Bowen, K.N., Yimlamai, D., Wu, Y.L., Kispert, A., Airik, R., & Hildebrandt, F. (2020). Loss of Anks6 leads to YAP deficiency and liver abnormalities. HUMAN MOLECULAR GENETICS, 29(18), 3064-3080.Oxford University Press (OUP). doi: 10.1093/hmg/ddaa197.

Han, L., Choudhury, S., Mich-Basso, J.D., Ammanamanchi, N., Ganapathy, B., Suresh, S., Khaladkar, M., Singh, J., Maehr, R., Zuppo, D.A., Kim, J., Eberwine, J.H., Wyman, S.K., Wu, Y.L., & Kuhn, B. (2020). Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration. DEVELOPMENTAL CELL, 53(1), 42-+.Elsevier BV. doi: 10.1016/j.devcel.2020.01.030.

Henkel, M., Partyka, J., Gregory, A.D., Forno, E., Cho, M.H., Eddens, T., Tout, A.R., Salamacha, N., Horne, W., Rao, K.S., Wu, Y., Alcorn, J.F., Kostka, D., Hirsch, R., Celedon, J.C., Shapiro, S.D., Kolls, J.K., & Campfield, B.T. (2020). FSTL-1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 201(8), 934-945.American Thoracic Society. doi: 10.1164/rccm.201905-0973OC.

Kapralov, A.A., Yang, Q., Dar, H.H., Tyurina, Y.Y., Anthonymuthu, T.S., Kim, R., St Croix, C.M., Mikulska-Ruminska, K., Liu, B., Shrivastava, I.H., Tyurin, V.A., Ting, H.C., Wu, Y.L., Gao, Y., Shurin, G.V., Artyukhova, M.A., Ponomareva, L.A., Timashev, P.S., Domingues, R.M., Stoyanovsky, D.A., Greenberger, J.S., Mallampalli, R.K., Bahar, I., Gabrilovich, D.I., Bayir, H., & Kagan, V.E. (2020). Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. NATURE CHEMICAL BIOLOGY, 16(3), 278-+.Springer Science and Business Media LLC. doi: 10.1038/s41589-019-0462-8.

Koppes, E.A., Redel, B.K., Johnson, M.A., Skvorak, K.J., Ghaloul-Gonzalez, L., Yates, M.E., Lewis, D.W., Gollin, S.M., Wu, Y.L., Christ, S.E., Yerle, M., Leshinski, A., Spate, L.D., Benne, J.A., Murphy, S.L., Samuel, M.S., Walters, E.M., Hansen, S.A., Wells, K.D., Lichter-Konecki, U., Wagner, R.A., Newsome, J.T., Dobrowolski, S.F., Vockley, J., Prather, R.S., & Nicholls, R.D. (2020). A porcine model of phenylketonuria generated by CRISPR/Cas9 genome editing. JCI INSIGHT, 5(20).American Society for Clinical Investigation. doi: 10.1172/jci.insight.141523.

Ling, X., Latoche, J.D., Choy, C.J., Kurland, B.F., Laymon, C.M., Wu, Y., Salamacha, N., Shen, D., Geruntho, J.J., Rigatti, L.H., Windish, H.P., Langton-Webster, B., Berkman, C.E., & Anderson, C.J. (2020). Preclinical Dosimetry, Imaging, and Targeted Radionuclide Therapy Studies of Lu-177-Labeled Albumin-Binding, PSMA-Targeted CTT1403. MOLECULAR IMAGING AND BIOLOGY, 22(2), 274-284.Springer Science and Business Media LLC. doi: 10.1007/s11307-019-01404-8.

Pang, D., Wu, Y.L., Alcamo, A.M., Cummings, J., Di Caro, V., III, W.T., Hsue, V., Clark, R.S.B., Panigrahy, A., Kochanek, P.M., & Aneja, R.K. (2020). EARLY AXONAL INJURY AND DELAYED CYTOTOXIC CEREBRAL EDEMA ARE ASSOCIATED WITH MICROGLIAL ACTIVATION IN A MOUSE MODEL OF SEPSIS. SHOCK, 54(2), 256-264.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/SHK.0000000000001446.

Rutledge, C., Cater, G., McMahon, B., Guo, L., Nouraie, S.M., Wu, Y., Villanueva, F., & Kaufman, B.A. (2020). Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction. CARDIOVASCULAR ULTRASOUND, 18(1), 9.Springer Science and Business Media LLC. doi: 10.1186/s12947-020-00191-5.

Liu, H., Zhang, C.H., Ammanamanchi, N., Suresh, S., Lewarchik, C., Rao, K., Uys, G.M., Han, L., Abrial, M., Yimlamai, D., Ganapathy, B., Guillermier, C., Chen, N., Khaladkar, M., Spaethling, J., Eberwine, J.H., Kim, J., Walsh, S., Choudhury, S., Little, K., Francis, K., Sharma, M., Viegas, M., Bais, A., Kostka, D., Ding, J., Bar-Joseph, Z., Wu, Y., Yechoor, V., Moulik, M., Johnson, J., Weinberg, J., Reyes-Mugica, M., Steinhauser, M.L., & Kuhn, B. (2019). Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. SCIENCE TRANSLATIONAL MEDICINE, 11(513).American Association for the Advancement of Science (AAAS). doi: 10.1126/scitranslmed.aaw6419.

Yagi, H., Liu, X., Gabriel, G.C., Wu, Y., Peterson, K., Murray, S.A., Aronow, B.J., Martin, L.J., Benson, D.W., & Lo, C.W. (2018). The Genetic Landscape of Hypoplastic Left Heart Syndrome. PEDIATRIC CARDIOLOGY, 39(6), 1069-1081.Springer Science and Business Media LLC. doi: 10.1007/s00246-018-1861-4.

Zahid, M., Feldman, K.S., Garcia-Borrero, G., Feinstein, T.N., Pogodzinski, N., Xu, X., Yurko, R., Czachowski, M., Wu, Y.L., Mason, N.S., & Lo, C.W. (2018). Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Bio-Distribution, Imaging Application, and Mechanism of Transduction. BIOMOLECULES, 8(4), 147.MDPI AG. doi: 10.3390/biom8040147.

Liu, X., Kim, A.J., Reynolds, W., Wu, Y., & Lo, C.W. (2017). Phenotyping cardiac and structural birth defects in fetal and newborn mice. BIRTH DEFECTS RESEARCH, 109(10), 778-790.Wiley. doi: 10.1002/bdr2.1048.

Liu, X., Yagi, H., Saeed, S., Bais, A.S., Gabriel, G.C., Chen, Z., Peterson, K.A., Li, Y., Schwartz, M.C., Reynolds, W.T., Saydmohammed, M., Gibbs, B., Wu, Y., Devine, W., Chatterjee, B., Klena, N.T., Kostka, D., Bentley, K.L.D.M., Ganapathiraju, M.K., Dexheimer, P., Leatherbury, L., Khalifa, O., Bhagat, A., Zahid, M., Pu, W., Watkins, S., Grossfeld, P., Murray, S.A., Jr, P.G.A., Tsang, M., Martin, L.J., Benson, D.W., Aronow, B.J., & Lo, C.W. (2017). The complex genetics of hypoplastic left heart syndrome. NATURE GENETICS, 49(7), 1152-+.Springer Science and Business Media LLC. doi: 10.1038/ng.3870.

Wu, Y.L., & Lo, C.W. (2017). Diverse application of MRI for mouse phenotyping. BIRTH DEFECTS RESEARCH, 109(10), 758-770.Wiley. doi: 10.1002/bdr2.1051.

Ye, Q., Liu, L., Wu, Y.L., Yeh, F., Li, W.F., Tseng, L., & Ho, C. (2017). Intralipid ® attenuates acute cardiac allograft rejection in relation to promoting CD4 + CD25 + Foxp3 + regulatory T-cells and inhibiting toll-like receptor 4 expression. Transplantation Reports, 2(1), 1-9.Elsevier BV. doi: 10.1016/j.tpr.2017.05.001.

Yeh, F.C., Liu, L., Hitchens, T.K., & Wu, Y.L. (2017). Mapping immune cell infiltration using restricted diffusion MRI. MAGNETIC RESONANCE IN MEDICINE, 77(2), 603-612.Wiley. doi: 10.1002/mrm.26143.

Ganapathy, B., Nandhagopal, N., Polizzotti, B.D., Bennett, D., Asan, A., Wu, Y., & Kuhn, B. (2016). Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth. In Calvert, J. (Ed.). PLOS ONE, 11(5), e0155456.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0155456.

Liu, L., Tseng, L., Ye, Q., Wu, Y.L., Bain, D.J., & Ho, C. (2016). A New Method for Preparing Mesenchymal Stem Cells and Labeling with Ferumoxytol for Cell Tracking by MRI. SCIENTIFIC REPORTS, 6(1), 26271.Springer Science and Business Media LLC. doi: 10.1038/srep26271.

Pearce, P.S., Wu, Y., Rapuano, A., Kelly, K.M., de Lanerolle, N., & Pan, J.W. (2016). Metabolic injury in a variable rat model of post-status epilepticus. EPILEPSIA, 57(12), 1978-1986.Wiley. doi: 10.1111/epi.13588.

Wu, Y., Pearce, P.S., Rapuano, A., Hitchens, T.K., de Lanerolle, N.C., & Pan, J.W. (2015). Metabolic changes in early poststatus epilepticus measured by MR spectroscopy in rats. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 35(11), 1862-1870.SAGE Publications. doi: 10.1038/jcbfm.2015.145.

Christodoulou, A.G., Hitchens, T.K., Wu, Y.L., Ho, C., & Liang, Z.P. (2014). Improved Subspace Estimation for Low-Rank Model-Based Accelerated Cardiac Imaging. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 61(9), 2451-2457.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TBME.2014.2320463.

Liu, L., Hitchens, T.K., Ye, Q., Wu, Y., Barbe, B., Prior, D.E., Li, W.F., Yeh, F.C., Foley, L.M., Bain, D.J., & Ho, C. (2013). Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with Intralipid. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1830(6), 3447-3453.Elsevier BV. doi: 10.1016/j.bbagen.2013.01.021.

Wu, Y.L., Ye, Q., Eytan, D.F., Liu, L., Rosario, B.L., Hitchens, T.K., Yeh, F.C., van Rooijen, N., & Ho, C. (2013). Magnetic Resonance Imaging Investigation of Macrophages in Acute Cardiac Allograft Rejection After Heart Transplantation. CIRCULATION-CARDIOVASCULAR IMAGING, 6(6), 965-973.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/CIRCIMAGING.113.000674.

Liu, L., Ye, Q., Wu, Y., Hsieh, W.Y., Chen, C.L., Shen, H.H., Wang, S.J., Zhang, H., Hitchens, T.K., & Ho, C. (2012). Tracking T-cells in vivo with a new nano-sized MRI contrast agent. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 8(8), 1345-1354.Elsevier BV. doi: 10.1016/j.nano.2012.02.017.

Chen, C.L., Zhang, H., Ye, Q., Hsieh, W.Y., Hitchens, T.K., Shen, H.H., Liu, L., Wu, Y.J., Foley, L.M., Wang, S.J., & Ho, C. (2011). A New Nano-sized Iron Oxide Particle with High Sensitivity for Cellular Magnetic Resonance Imaging. MOLECULAR IMAGING AND BIOLOGY, 13(5), 825-839.Springer Science and Business Media LLC. doi: 10.1007/s11307-010-0430-x.

Wu, Y.L., Ye, Q., & Ho, C. (2011). Cellular and Functional Imaging of Cardiac Transplant Rejection. Curr Cardiovasc Imaging Rep, 4(1), 50-62.Springer Science and Business Media LLC. doi: 10.1007/s12410-010-9055-3.

Wu, Y.L., Ye, Q., Sato, K., Foley, L.M., Hitchens, T.K., & Ho, C. (2009). Noninvasive Evaluation of Cardiac Allograft Rejection by Cellular and Functional Cardiac Magnetic Resonance. JACC-CARDIOVASCULAR IMAGING, 2(6), 731-741.Elsevier BV. doi: 10.1016/j.jcmg.2009.01.013.

Mills, P.H., Wu, Y.J.L., Ho, C., & Ahrens, E.T. (2008). Sensitive and automated detection of iron-oxide-labeled cells using phase image cross-correlation analysis. Magn Reson Imaging, 26(5), 618-628.Elsevier BV. doi: 10.1016/j.mri.2008.01.007.

Ye, Q., Wu, Y.L., Foley, L.M., Hitchens, T.K., Eytan, D.F., Shirwan, H., & Ho, C. (2008). longitudinal tracking of recipient macrophages in a rat chronic cardiac allograft rejection model with noninvasive magnetic resonance imaging using micrometer-sized paramagnetic iron oxide particles. CIRCULATION, 118(2), 149-156.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/CIRCULATIONAHA.107.746354.

Chang, H.H., Moura, J.M.F., Wu, Y.L., & Ho, C. (2006). Immune cells detection of the in vivo rejecting heart in USPIO-enhanced magnetic resonance imaging. Conf Proc IEEE Eng Med Biol Soc, 2006, 942-945.IEEE. doi: 10.1109/iembs.2006.259443.

Wu, Y.L., Ye, Q., Foley, L.M., Hitchens, T.K., Sato, K., Williams, J.B., & Ho, C. (2006). In situ labeling of immune cells with iron oxide particles:: An approach to detect organ rejection by cellular MRI. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(6), 1852-1857.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0507198103.

Aoki, I., Wu, Y.J.L., Silva, A.C., Lynch, R.M., & Koretsky, A.P. (2004). In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI. NEUROIMAGE, 22(3), 1046-1059.Elsevier BV. doi: 10.1016/j.neuroimage.2004.03.031.

Wu, Y.J.L., Sato, K., Ye, Q., & Ho, C. (2004). MRI investigations of graft rejection following organ transplantation using rodent models. IMAGING IN BIOLOGICAL RESEARCH, PT B, 386, 73-105.Elsevier. doi: 10.1016/S0076-6879(04)86003-8.

Kanno, S., Wu, Y.J., Lee, P.C., Dodd, S.J., Williams, M., Griffith, B.P., & Ho, C. (2001). Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles. Circulation, 104(8), 934-938.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/hc3401.093148.

Kanno, S., Wu, Y.J.L., Lee, P.C., Billiar, T.R., & Ho, C. (2001). Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats. CIRCULATION, 104(8), 945-950.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/hc3401.093155.