Mohamed Ezzelarab

  • MD, Alexandria University

  • Kubo, M., Hidaka, Y., Casto, L.L., Vujevich, V., Lesniak, A., Gunabushanam, V., Ganoza, A., Wijkstrom, M.J., Humar, A., Demetris, A.J., Thomson, A.W., & Ezzelarab, M.B. (2026). Peri-transplant Interleukin-6 Receptor Blockade delays Acute Cellular Rejection and Significantly Prolongs Kidney Allograft Survival in Tacrolimus/CTLA4Ig-treated Nonhuman Primates. Am J Transplant, S1600-6135(26)00170-X.Elsevier. doi: 10.1016/j.ajt.2026.03.020.
  • Shirini, K., Ezzelarab, M.B., Loupy, A., Meier, R.P.H., & Ekser, B. (2026). The First Pig-to-human Liver Xenotransplantation From Genetically Engineered Pig: A Game Changer in Bridging Therapy. Transplantation.Wolters Kluwer. doi: 10.1097/TP.0000000000005648.
  • Ubaid, M.F., Ezzelarab, M.B., & Cooper, D.K.C. (2026). The Relative Roles of Inflammation in Kidney Allotransplantation and Xenotransplantation. Transplantation, 110(1), e80-e89.Wolters Kluwer. doi: 10.1097/TP.0000000000005518.
  • Ueda, H., Abdullah, M., Richards, T., Casto, L., Kubo, M., Phillippi, J.A., Kaczarawoski, D., & Ezzelarab, M.B. (2026). Recent Developments in Therapeutic Targeting of Interleukin-6 in Clinical Solid Organ Transplantation. CURRENT TRANSPLANTATION REPORTS, 13(1).Springer Nature. doi: 10.1007/s40472-026-00509-8.
  • Saleh, A.K., Ramadan, H.S.I., Abdelhameed, S.M., Ezzelarab, M., Elsawy, A.G.S., Ahmed, S.S., Abdel-Aziz, M.M., Elshehawy, N.A., Zahran, G.E., Ibrahiem, N.M., & Alshahrani, N.N. (2025). Perioperative Use of Melatonin in Joint Arthroplasty: A Critical Systematic Review of Randomized Clinical Studies. J Pain Palliat Care Pharmacother, 39(2), 276-285.Taylor & Francis. doi: 10.1080/15360288.2025.2490654.
  • Abou-Daya, K.I., Moussawy, M.A., Kubo, M., Lu, L., Perez-Gutierrez, A., & Ezzelarab, M.B. (2024). Distinct Pro-Inflammatory Species-Specific Transcriptional Changes in Human T Cells Following Pig Xenogeneic Stimulation. Xenotransplantation, 31(6), e70007.Wiley. doi: 10.1111/xen.70007.
  • EGLAND, K.A., MAHER, D., SANDHURST, E.S., WU, H., SAVINOV, A.Y., EZZELARAB, M., BAUSCH, C.L., & LUKE, T.C. (2024). 885-P: IND-Enabling Assessment of Tolerance and Safety for SAB-142—A First-in-Class Fully Human Polyclonal Antithymocyte Immunoglobulin to Delay the Progression of Type 1 Diabetes. Diabetes, 73(Supplement_1).American Diabetes Association. doi: 10.2337/db24-885-p.
  • Sasaki, K., Kubo, M., Wang, Y.C., Lu, L., Vujevich, V., Wood-Trageser, M.A., Golnoski, K., Lesniak, A., Gunabushanam, V., Ganoza, A., Wijkstrom, M.J., Humar, A., Demetris, A.J., Thomson, A.W., & Ezzelarab, M.B. (2024). Multiple infusions of ex vivo-expanded regulatory T cells promote CD163+ myeloid cells and kidney allograft survival in non-lymphodepleted non-human primates. Kidney Int, 105(1), 84-98.Elsevier. doi: 10.1016/j.kint.2023.09.021.
  • Ezzelarab, M.B., Hara, H., Ayares, D., & Cooper, D.K.C. (2023). Systemic inflammation in the xenotransplant recipient (SIXR) can occur in the absence of pCMV infection. Xenotransplantation, 30(2), e12796.Wiley. doi: 10.1111/xen.12796.
  • Kenta, I., Toshihide, T., Takashi, S., Shintaro, S., Yuko, M., Manabu, O., Takahisa, H., Norihiko, G., Shunji, N., Yoshihiko, W., Mai, O., Satoshi, A., Kohei, I., Ezzelarab, M.B., & Takaaki, K. (2023). Estimation of Sensitization Status in Renal Transplant Recipients by Assessing Indirect Pathway CD4 + T Cell Response to Donor Cell-pulsed Dendritic Cell. Transplantation, 107(5), 1079-1088.Wolters Kluwer. doi: 10.1097/TP.0000000000004491.
  • Omar, A., Kaseb, A., Elbaz, T., El-Kassas, M., El Fouly, A., Hanno, A.F., El Dorry, A., Hosni, A., Helmy, A., Saad, A.S., Alolayan, A., Eysa, B.E., Hamada, E., Azim, H., Khattab, H., Elghazaly, H., Tawfik, H., Ayoub, H., Khaled, H., Saadeldin, I., Waked, I., Barakat, E.M.F., El Meteini, M., Hamed Shaaban, M., EzzElarab, M., Fathy, M., Shaker, M., Sobhi, M., Shaker, M.K., ElGharib, M., Abdullah, M., Mokhtar, M., Elshazli, M., Heikal, O.M.K., Hetta, O., ElWakil, R.M., Abdel Wahab, S., Eid, S.S., Rostom, Y., & Egyptian Liver Cancer Committee Study Group. (2023). Egyptian Society of Liver Cancer Recommendation Guidelines for the Management of Hepatocellular Carcinoma. J Hepatocell Carcinoma, 10(0), 1547-1571.Taylor & Francis. doi: 10.2147/JHC.S404424.
  • 研太, 岩., 俊英, 友., 高史, 関., 祐子, 三., Ezzelarab, M.B., Lu, X., 晶, 山., 真人, 雫., 聡, 安., 宏平, 石., & 孝彰, 小. (2023). DCを用いたCD4 T細胞培養系によるIndirect alloresponse評価. 移植, 58(Supplement), s237_1. doi: 10.11386/jst.58.supplement_s237_1.
  • Elgendy, T.Y., Waldner, M., Zhang, W., Kim, D.Y., Minervini, M.I., Komatsu, C., Kulahci, Y., Washington, K.M., Gorantla, V.S., Ezzelarab, M.B., Solari, M.G., & Thomson, A.W. (2022). Tacrolimus before CTLA4Ig and rapamycin promotes vascularized composite allograft survival in MGH miniature swine. Transpl Immunol, 75, 101696.Elsevier. doi: 10.1016/j.trim.2022.101696.
  • Litovsky, S.H., Foote, J.B., Jagdale, A., Walcott, G., Iwase, H., Bikhet, M.H., Yamamoto, T., Hansen-Estruch, C., Ezzelarab, M.B., Ayares, D., Carlo, W.F., Rhodes, L.A., Crawford, J.H., Borasino, S., Dabal, R.J., Padilla, L.A., Hara, H., Cooper, D.K.C., & Cleveland, D.C. (2022). Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation. Ann Transplant, 27, e935338.International Scientific Information. doi: 10.12659/AOT.935338.
  • 研太, 岩., 俊英, 友., 高史, 関., 祐子, 三., 宏平, 石., 聡, 安., Ezzelarab, M.B., Lu, X., 晶, 山., & 孝彰, 小. (2022). In silico DSA産生予測と、樹状細胞を用いたindirect alloresponse検出系による感作把握. 移植, 57(Supplement), s158_1. doi: 10.11386/jst.57.supplement_s158_1.
  • Bikhet, M., Iwase, H., Yamamoto, T., Jagdale, A., Foote, J.B., Ezzelarab, M., Anderson, D.J., Locke, J.E., Eckhoff, D.E., Hara, H., & Cooper, D.K.C. (2021). What Therapeutic Regimen Will Be Optimal for Initial Clinical Trials of Pig Organ Transplantation?. Transplantation, 105(6), 1143-1155.Wolters Kluwer. doi: 10.1097/TP.0000000000003622.
  • Elhussiny, M.E.A., Omar, N., Rageh, K.A., Ali, M.H., Fayad, S., Elnawasany, M.A., Khalifa, A.M., & Ezzelarab, M. (2021). Endometrial biopsy in females with abnormal uterine bleeding: Clinical and histopathological patterns. MEDICAL SCIENCE, 25(110), 891-899.
  • Ezzelarab, M.B., Zhang, H., Sasaki, K., Lu, L., Zahorchak, A.F., van der Windt, D.J., Dai, H., Perez-Gutierrez, A., Bhama, J.K., & Thomson, A.W. (2021). Ex Vivo Expanded Donor Alloreactive Regulatory T Cells Lose Immunoregulatory, Proliferation, and Antiapoptotic Markers After Infusion Into ATG-lymphodepleted, Nonhuman Primate Heart Allograft Recipients. Transplantation, 105(9), 1965-1979.Wolters Kluwer. doi: 10.1097/TP.0000000000003617.
  • Foote, J.B., Jagdale, A., Yamamoto, T., Hara, H., Bikhet, M.H., Schuurman, H.J., Nguyen, H.Q., Ezzelarab, M., Ayares, D., Anderson, D.J., Fatima, H., Eckhoff, D.E., Cooper, D.K.C., & Iwase, H. (2021). Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons. Xenotransplantation, 28(6), e12715.Wiley. doi: 10.1111/xen.12715.
  • Iwase, H., Jagdale, A., Yamamoto, T., Bikhet, M.H., Nguyen, H.Q., Ezzelarab, M., Ayares, D., Anderson, D.J., Eckhoff, D.E., Foote, J.B., Fatima, H., Schuurman, H.J., Hara, H., & Cooper, D.K.C. (2021). Evidence suggesting that deletion of expression of N-glycolylneuraminic acid (Neu5Gc) in the organ-source pig is associated with increased antibody-mediated rejection of kidney transplants in baboons. Xenotransplantation, 28(4), e12700.Wiley. doi: 10.1111/xen.12700.
  • Thomson, A.W., Sasaki, K., & Ezzelarab, M.B. (2021). Non-human Primate Regulatory T Cells and Their Assessment as Cellular Therapeutics in Preclinical Transplantation Models. Front Cell Dev Biol, 9, 666959.Frontiers. doi: 10.3389/fcell.2021.666959.
  • Zhang, G., Iwase, H., Li, Q., Yamamoto, T., Jagdale, A., Ezzelarab, M.B., Ayares, D., Cooper, D.K.C., Hara, H., & Wang, G. (2021). The Role of Interleukin-6 (IL-6) in the Systemic Inflammatory Response in Xenograft Recipients and in Pig Kidney Xenograft Failure. Front Immunol, 12, 788949.Frontiers. doi: 10.3389/fimmu.2021.788949.
  • Cooper, D.K.C., Ezzelarab, M.B., Hara, H., Iwase, H., Lee, W., Wijkstrom, M., & Bottino, R. (2020). The Pathobiology of Pig-to-Primate Xeno.: A Historical Review. In Clinical Xenotransplantation. (pp. 27-63).Springer Nature. doi: 10.1007/978-3-030-49127-7_2.
  • Ezzelarab, M.B., & Thomson, A.W. (2020). Plasmacytoid Dendritic Cells and the Spontaneous Acceptance of Kidney Allografts. Transplantation, 104(1), 15-16.Wolters Kluwer. doi: 10.1097/TP.0000000000002868.
  • Sasaki, K., Wang, Y.C., Lu, L., Hughes, J., Vujevich, V., Thomson, A.W., & Ezzelarab, M.B. (2020). Combined GM-CSF and G-CSF administration mobilizes CD4+ CD25hi Foxp3hi Treg in leukapheresis products of rhesus monkeys. Am J Transplant, 20(6), 1691-1702.Elsevier. doi: 10.1111/ajt.15761.
  • Sasaki, K., Wang, Y.C., Lu, L., Hughes, J., Vujevich, V., Thomson, A.W., & Ezzelarab, M.B. (2020). GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF) AND GRANULOCYTE-MACROPHAGE CSF (GM-CSF) ADMINISTRATION ENRICHES FOR HIGHLY SUPPRESSIVE CD4+CD45RA-FOXP3HI CELLS IN LEUKAPHERESIS PRODUCTS OF RHESUS MONKEYS. Transplantation, 104(S3), s44.Wolters Kluwer. doi: 10.1097/01.tp.0000698476.28268.28.
  • Sasaki, K., Wang, Y.C., Nakano, R., Lu, L., Hughes, J., Vujevich, V., Ganoza, A.J., Wijkstrom, M.N., Humar, A., Thomson, A.W., & Ezzelarab, M.B. (2020). EARLY POST-TRANSPLANT INFUSION OF EX VIVO-EXPANDED AUTOLOGOUS POLYCLONAL REGULATORY T CELLS (TREG) PROLONGS KIDNEY ALLOGRAFT SURVIVAL IN NONLYMPHODEPLETED, CTLA4IG-TREATED RHESUS MONKEYS. Transplantation, 104(S3), s143.Wolters Kluwer. doi: 10.1097/01.tp.0000699024.87080.90.
  • Thomson, A.W., & Ezzelarab, M.B. (2020). Generation and functional assessment of nonhuman primate regulatory dendritic cells and their therapeutic efficacy in renal transplantation. Cell Immunol, 351, 104087.Elsevier. doi: 10.1016/j.cellimm.2020.104087.
  • Cooper, D.K.C., Hara, H., Iwase, H., Yamamoto, T., Li, Q., Ezzelarab, M., Federzoni, E., Dandro, A., & Ayares, D. (2019). Justification of specific genetic modifications in pigs for clinical organ xenotransplantation. Xenotransplantation, 26(4), e12516.Wiley. doi: 10.1111/xen.12516.
  • Ezzelarab, M.B., Perez-Gutierrez, A., Humar, A., Wijkstrom, M., Zahorchak, A.F., Lu-Casto, L., Wang, Y.C., Wiseman, R.W., Minervini, M., & Thomson, A.W. (2019). Preliminary assessment of the feasibility of autologous myeloid-derived suppressor cell infusion in non-human primate kidney transplantation. Transpl Immunol, 56, 101225.Elsevier. doi: 10.1016/j.trim.2019.101225.
  • Thomson, A.W., Metes, D.M., Ezzelarab, M.B., & Raïch-Regué, D. (2019). Regulatory dendritic cells for human organ transplantation. Transplant Rev (Orlando), 33(3), 130-136.Elsevier. doi: 10.1016/j.trre.2019.05.001.
  • Yamamoto, T., Hara, H., Foote, J., Wang, L., Li, Q., Klein, E.C., Schuurman, H.J., Zhou, H., Li, J., Tector, A.J., Zhang, Z., Ezzelarab, M., Lovingood, R., Ayares, D., Eckhoff, D.E., Cooper, D.K.C., & Iwase, H. (2019). Life-supporting Kidney Xenotransplantation From Genetically Engineered Pigs in Baboons: A Comparison of Two Immunosuppressive Regimens. Transplantation, 103(10), 2090-2104.Wolters Kluwer. doi: 10.1097/TP.0000000000002796.
  • Cooper, D.K.C., Ezzelarab, M., Iwase, H., & Hara, H. (2018). Perspectives on the Optimal Genetically Engineered Pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation. Transplantation, 102(12), 1974-1982.Wolters Kluwer. doi: 10.1097/TP.0000000000002443.
  • Elgendy, T., Kim, D., Waldner, M., Zhang, W., Zahorchak, A., Minervini, M., Washington, K.M., Ezzelarab, M., Solari, M.G., & Thomson, A.W. (2018). Abstract. Plastic & Reconstructive Surgery Global Open, 6(9S), 16-17.Wolters Kluwer. doi: 10.1097/01.gox.0000546733.03805.97.
  • Ezzelarab, M.B. (2018). Regulatory T cells from allo- to xenotransplantation: Opportunities and challenges. Xenotransplantation, 25(3), e12415.Wiley. doi: 10.1111/xen.12415.
  • Ezzelarab, M.B., Lu, L., Shufesky, W.F., Morelli, A.E., & Thomson, A.W. (2018). Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade. Front Immunol, 9(FEB), 250.Frontiers. doi: 10.3389/fimmu.2018.00250.
  • Li, T., Hara, H., Ezzelarab, M.B., Long, C., Long, Y., Wang, Y., Cooper, D.K.C., & Iwase, H. (2018). Serum amyloid A as a marker of inflammation in xenotransplantation. EUROPEAN JOURNAL OF INFLAMMATION, 16.SAGE Publications. doi: 10.1177/2058739218780046.
  • Perez-Gutierrez, A., Metes, D.M., Lu, L., Hariharan, S., Thomson, A.W., & Ezzelarab, M.B. (2018). Characterization of eomesodermin and T-bet expression by allostimulated CD8+ T cells of healthy volunteers and kidney transplant patients in relation to graft outcome. Clin Exp Immunol, 194(2), 259-272.Oxford University Press (OUP). doi: 10.1111/cei.13162.
  • Thomson, A.W., & Ezzelarab, M.B. (2018). Regulatory dendritic cells: profiling, targeting, and therapeutic application. Curr Opin Organ Transplant, 23(5), 538-545.Wolters Kluwer. doi: 10.1097/MOT.0000000000000565.
  • Yamamoto, T., Li, Q., Hara, H., Wang, L., Zhou, H., Li, J., Eckhoff, D.E., Joseph Tector, A., Klein, E.C., Lovingood, R., Ezzelarab, M., Ayares, D., Wang, Y., Cooper, D.K.C., & Iwase, H. (2018). B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy. Transpl Immunol, 51, 12-20.Elsevier. doi: 10.1016/j.trim.2018.08.005.
  • Yamamoto, T., Li, Q., Hara, H., Wang, L., Zhou, H., Li, J., Eckhoff, D.E., Tector, A.J., Klein, E.C., Lovingood, R., Ezzelarab, M., Ayares, D., Wang, Y., Cooper, D.K.C., & Iwase, H. (2018). Data on B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy. Data Brief, 20, 1965-1974.Elsevier. doi: 10.1016/j.dib.2018.08.213.
  • Zahorchak, A.F., Perez-Gutierrez, A., Ezzelarab, M.B., & Thomson, A.W. (2018). Monocytic myeloid-derived suppressor cells generated from rhesus macaque bone marrow enrich for regulatory T cells. Cell Immunol, 329, 50-55.Elsevier. doi: 10.1016/j.cellimm.2018.04.013.
  • Zhang, Z., Hara, H., Long, C., Iwase, H., Qi, H., Macedo, C., Mangiola, M., Zeevi, A., Ezzelarab, M., Ayares, D., Cooper, D.K.C., & Wijkstrom, M. (2018). Immune Responses of HLA Highly Sensitized and Nonsensitized Patients to Genetically Engineered Pig Cells. Transplantation, 102(5), e195-e204.Wolters Kluwer. doi: 10.1097/TP.0000000000002060.
  • Cooper, D.K.C., Ezzelarab, M.B., & Hara, H. (2017). Low anti-pig antibody levels are key to the success of solid organ xenotransplantation: But is this sufficient?. Xenotransplantation, 24(6).Wiley. doi: 10.1111/xen.12360.
  • Ezzelarab, M.B., Raich-Regue, D., Lu, L., Zahorchak, A.F., Perez-Gutierrez, A., Humar, A., Wijkstrom, M., Minervini, M., Wiseman, R.W., Cooper, D.K.C., Morelli, A.E., & Thomson, A.W. (2017). Renal Allograft Survival in Nonhuman Primates Infused With Donor Antigen-Pulsed Autologous Regulatory Dendritic Cells. Am J Transplant, 17(6), 1476-1489.Elsevier. doi: 10.1111/ajt.14182.
  • Gao, B., Long, C., Lee, W., Zhang, Z., Gao, X., Landsittel, D., Ezzelarab, M., Ayares, D., Huang, Y., Cooper, D.K.C., Wang, Y., & Hara, H. (2017). Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans. In Chammas, R. (Ed.). PLoS One, 12(7), e0180768.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0180768.
  • Hawthorne, W.J., Cimeno, A., Ezzelarab, M., Sandhu, B., & Burlak, C. (2017). Thomas Starzl-Visionary and xenotransplantation pioneer: Commentary from the International Xenotransplant Association Vanguard Committee. Xenotransplantation, 24(2).Wiley. doi: 10.1111/xen.12310.
  • Iwase, H., Hara, H., Ezzelarab, M., Li, T., Zhang, Z., Gao, B., Liu, H., Long, C., Wang, Y., Cassano, A., Klein, E., Phelps, C., Ayares, D., Humar, A., Wijkstrom, M., & Cooper, D.K.C. (2017). Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts. Xenotransplantation, 24(2).Wiley. doi: 10.1111/xen.12293.
  • Iwase, H., Liu, H., Li, T., Zhang, Z., Gao, B., Hara, H., Wijkstrom, M., Long, C., Saari, R., Ayares, D., Cooper, D.K.C., & Ezzelarab, M.B. (2017). Therapeutic regulation of systemic inflammation in xenograft recipients. Xenotransplantation, 24(2).Wiley. doi: 10.1111/xen.12296.
  • Iwase, H., Liu, H., Schmelzer, E., Ezzelarab, M., Wijkstrom, M., Hara, H., Lee, W., Singh, J., Long, C., Lagasse, E., Gerlach, J.C., Cooper, D.K.C., & Gridelli, B. (2017). Transplantation of hepatocytes from genetically engineered pigs into baboons. Xenotransplantation, 24(2).Wiley. doi: 10.1111/xen.12289.
  • Li, T., Lee, W., Hara, H., Long, C., Ezzelarab, M., Ayares, D., Huang, H., Wang, Y., Esmon, C.T., Cooper, D.K.C., & Iwase, H. (2017). An Investigation of Extracellular Histones in Pig-To-Baboon Organ Xenotransplantation. Transplantation, 101(10), 2330-2339.Wolters Kluwer. doi: 10.1097/TP.0000000000001676.
  • Thomson, A.W., & Ezzelarab, M.B. (2017). A Tale of Two Pathways: Renewing the Promise of Anti-CD40L Blockade. Am J Transplant, 17(5), 1156-1157.Elsevier. doi: 10.1111/ajt.14217.
  • Wijkstrom, M., Iwase, H., Paris, W., Hara, H., Ezzelarab, M., & Cooper, D.K.C. (2017). Renal xenotransplantation: experimental progress and clinical prospects. Kidney Int, 91(4), 790-796.Elsevier. doi: 10.1016/j.kint.2016.08.035.
  • Zhang, Z., Gao, B., Zhao, C., Long, C., Qi, H., Ezzelarab, M., Cooper, D.K., & Hara, H. (2017). The impact of serum incubation time on IgM/IgG binding to porcine aortic endothelial cells. Xenotransplantation, 24(4).Wiley. doi: 10.1111/xen.12312.
  • Cooper, D.K.C., Ezzelarab, M.B., Hara, H., Iwase, H., Lee, W., Wijkstrom, M., & Bottino, R. (2016). The pathobiology of pig-to-primate xenotransplantation: a historical review. Xenotransplantation, 23(2), 83-105.Wiley. doi: 10.1111/xen.12219.
  • Ezzelarab, M.B., & Thomson, A.W. (2016). Adoptive Cell Therapy with Tregs to Improve Transplant Outcomes: The Promise and the Stumbling Blocks. Curr Transplant Rep, 3(4), 265-274.Springer Nature. doi: 10.1007/s40472-016-0114-9.
  • Ezzelarab, M.B., Lu, L., Guo, H., Zahorchak, A.F., Shufesky, W.F., Cooper, D.K.C., Morelli, A.E., & Thomson, A.W. (2016). Eomesodermin(lo) CTLA4(hi) Alloreactive CD8+ Memory T Cells Are Associated With Prolonged Renal Transplant Survival Induced by Regulatory Dendritic Cell Infusion in CTLA4 Immunoglobulin-Treated Nonhuman Primates. Transplantation, 100(1), 91-102.Wolters Kluwer. doi: 10.1097/tp.0000000000000871.
  • Ezzelarab, M.B., Zhang, H., Guo, H., Lu, L., Zahorchak, A.F., Wiseman, R.W., Nalesnik, M.A., Bhama, J.K., Cooper, D.K.C., & Thomson, A.W. (2016). Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients. Am J Transplant, 16(7), 1999-2015.Elsevier. doi: 10.1111/ajt.13685.
  • Guo, H., Lu, L., Wang, R., Perez-Gutierrez, A., Abdulkerim, H.S., Zahorchak, A.F., Sumpter, T.L., Reimann, K.A., Thomson, A.W., & Ezzelarab, M.B. (2016). Impact of Human Mutant TGFβ1/Fc Protein on Memory and Regulatory T Cell Homeostasis Following Lymphodepletion in Nonhuman Primates. Am J Transplant, 16(10), 2994-3006.Elsevier. doi: 10.1111/ajt.13883.
  • Iwase, H., Ekser, B., Hara, H., Ezzelarab, M.B., Long, C., Thomson, A.W., Ayares, D., & Cooper, D.K.C. (2016). Thyroid hormone: relevance to xenotransplantation. Xenotransplantation, 23(4), 293-299.Wiley. doi: 10.1111/xen.12243.
  • Lee, W., Hara, H., Ezzelarab, M.B., Iwase, H., Bottino, R., Long, C., Ramsoondar, J., Ayares, D., & Cooper, D.K.C. (2016). Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs. Xenotransplantation, 23(2), 137-150.Wiley. doi: 10.1111/xen.12229.
  • Thomson, A.W., Zahorchak, A.F., Ezzelarab, M.B., Butterfield, L.H., Lakkis, F.G., & Metes, D.M. (2016). Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation. Front Immunol, 7(JAN), 15.Frontiers. doi: 10.3389/fimmu.2016.00015.
  • Zahorchak, A.F., Ezzelarab, M.B., Lu, L., Turnquist, H.R., & Thomson, A.W. (2016). In Vivo Mobilization and Functional Characterization of Nonhuman Primate Monocytic Myeloid-Derived Suppressor Cells. Am J Transplant, 16(2), 661-671.Elsevier. doi: 10.1111/ajt.13454.
  • Azimzadeh, A.M., Kelishadi, S.S., Ezzelarab, M.B., Singh, A.K., Stoddard, T., Iwase, H., Zhang, T., Burdorf, L., Sievert, E., Avon, C., Cheng, X., Ayares, D., Horvath, K.A., Corcoran, P.C., Mohiuddin, M.M., Barth, R.N., Cooper, D.K.C., & Pierson, R.N. (2015). Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein. Xenotransplantation, 22(4), 310-316.Wiley. doi: 10.1111/xen.12176.
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  • Hidaka, Y., Kubo, M., Lu, L., Gutierrez, A.P., Gunabushanam, V., Ganoza, A., Wijkstrom, M., Humar, A., Lakkis, F., Thomson, A., & Ezzelarab, M.B. (2024). Donor-Reactive Effector CD8+PD1+T Cells Correlate with CTLA4Ig-Resistant Rejection in Kidney Allograft Recipient Monkeys. In AMERICAN JOURNAL OF TRANSPLANTATION, 24(6), (pp. S708-S709).
  • Abou-Daya, K.I., Kubo, M., Perez-Gutierrez, A., Casto, L.L., Thomson, A.W., & Ezzelarab, M.B. (2023). Pig Xenogeneic Stimulation of Human T Cells Induces Unique Transcriptional Changes Associated with Pro-Coagulant and Pro-Inflammatory Responses. In AMERICAN JOURNAL OF TRANSPLANTATION, 23(6), (pp. S1077-S1078).
  • Kubo, M., Sasaki, K., Lu, L., Vujevich, V., Gunabushanam, V., Ganoza, A., Wijkstrom, M., Humar, A., Thomson, A., & Ezzelarab, M. (2023). IL-6 Receptor Blockade Attenuates Effector T Cell Function and Significantly Prolongs Kidney Allograft Survival in CTLA4Ig-Treated Rhesus Monkeys. In AMERICAN JOURNAL OF TRANSPLANTATION, 23(6), (p. S765).
  • Kubo, M., Sasaki, K., Lu, L., Vujevich, V., Wood-Trageser, M.A., Golnoski, K., Lesniak, A., Gunabushanam, V., Ganoza, A., Wijkstrom, M., Demetris, A., Humar, A., Thomson, A., & Ezzelarab, M. (2023). Multiple Infusions of Ex Vivo-Expanded Polyclonal Treg Delay Rejection and Promote Systemic and Intragraft CD163+ Myeloid Cells in Kidney Allograft Recipient Monkeys. In AMERICAN JOURNAL OF TRANSPLANTATION, 23(6), (pp. S554-S555).
  • Luke, T., Sandhurst, E., Wu, H., Maher, D., Kropotova, A., Ezzelarab, M., Griffin, K., Wollman, J., Savinov, A., Sullivan, E., & Bausch, C. (2023). Safety and Efficacy of a Novel Fully Human Polyclonal IgG Anti-Thymocyte Immunoglobulin in a Non-Human-Primate IND Enabling Study. In AMERICAN JOURNAL OF TRANSPLANTATION, 23(6), (pp. S771-S772).
  • Kubo, M., Sasaki, K., Lu, L., Vujevich, V., Thomson, A., & Ezzelarab, M. (2022). Identification of Highly-Effective Donor-Reactive CD4+CD8αlo T Cells in CTLA4Ig-Treated Renal Allograft Recipient Monkeys. In AMERICAN JOURNAL OF TRANSPLANTATION, 22, (p. 740).
  • Bikhet, M., Cooper, D.K.C., Litovsky, S., Foote, J.B., Jagdale, A., Walcott, G., Iwase, H., Yamamoto, T., Hansen-Estruch, C., Ezzelarab, M.M., Ayares, D., Waldemar, C.F., Rhodes, L.A., Crawford, J., Borasino, S., Dabal, R., Hara, H., & Cleveland, D. (2021). INITIAL EXPERIENCE OF ORTHOTOPIC TRANSPLANTATION OF GENETICALLY ENGINEERED PIG HEARTS IN BABOONS. In XENOTRANSPLANTATION, 28(5).
  • Kubo, M., Sasaki, K., Gutierrez, A.P., Lu, L., Vujevich, V., Thomson, A.W., & Ezzelarab, M. (2021). Naive Rhesus Monkey CD4+CD8loT Cells Comprise High Percentage of Memory T Cells with Strong Effector Function. In AMERICAN JOURNAL OF TRANSPLANTATION, 21, (p. 538).
  • Sasaki, K., Wang, Y., Lu, L., Hughes, J., Vujevich, V., Thomson, A.W., & Ezzelarab, M.B. (2020). Granulocyte-Colony Stimulating Factor (G-CSF) and Granulocyte-Macrophage CSF (GM-CSF) Administration Enriches for Highly Suppressive CD4+CD45RA-Foxp3hi Cells in Leukapheresis Products of Rhesus Monkeys. In AMERICAN JOURNAL OF TRANSPLANTATION, 20, (p. 713).
  • Sasaki, K., Wang, Y., Nakano, R., Lu, L., Hughes, J., Vujevich, V., Ganoza, A.J., Wijkstrom, M., Humar, A., Thomson, A.W., & Ezzelarab, M.B. (2020). Early Post-Transplant Infusion of Ex Vivo-Expanded Autologous Polyclonal Regulatory T Cells (Treg) Prolongs Kidney Allograft Survival in Non-Lymphodepleted, CTLA4Ig-Treated Rhesus Monkeys. In AMERICAN JOURNAL OF TRANSPLANTATION, 20, (p. 340).
  • Sasaki, K., Wang, Y.C., Lu, L., Hughes, J., Vujevich, V., Thomson, A.W., & Ezzelarab, M.B. (2020). GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF) AND GRANULOCYTE-MACROPHAGE CSF (GM-CSF) ADMINISTRATION ENRICHES FOR HIGHLY SUPPRESSIVE CD4+CD45RA-FOXP3HI CELLS IN LEUKAPHERESIS PRODUCTS OF RHESUS MONKEYS. In TRANSPLANTATION, 104(9), (p. S44).
  • Sasaki, K., Wang, Y.C., Nakano, R., Lu, L., Hughes, J., Vujevich, V., Ganoza, A.J., Wijkstrom, M.N., Humar, A., Thomson, A.W., & Ezzelarab, M.B. (2020). EARLY POST-TRANSPLANT INFUSION OF EX VIVO-EXPANDED AUTOLOGOUS POLYCLONAL REGULATORY T CELLS (TREG) PROLONGS KIDNEY ALLOGRAFT SURVIVAL IN NONLYMPHODEPLETED, CTLA4IG-TREATED RHESUS MONKEYS. In TRANSPLANTATION, 104(9), (p. S143).
  • Wang, Y., Kazuki, S., Lu, L., Zahorchak, A., Dai, H., Ganoza, A., Wijkstrom, M., Humar, A., Ezzelarab, M., & Thomson, A. (2020). Donor-Derived DCREG Infusion Prolongs Kidney Allograft Survival in Rhesus Monkeys Treated with Co-Stimulation Blockade and Calcineurin Inhibition. In AMERICAN JOURNAL OF TRANSPLANTATION, 20, (p. 340).
  • Gutierrez, A.P., Thomson, A.W., Metes, D.M., & Ezzelarab, M.B. (2019). Phenotypic and Functional Analysis of Non-Activated and Allo-Activated Eomesodermin+CD8+T Cells in Humans and Nonhuman Primates. In AMERICAN JOURNAL OF TRANSPLANTATION, 19, (pp. 1085-1086).
  • Sasaki, K., Wang, Y., Lu, L., Hughs, J., Thomson, A.W., & Ezzelarab, M.B. (2019). Granulocyte - Colony Stimulating Factor (G-CSF) and Granulocyte - Macrophage Colony Stimulating Factor (GM-CSF) Administration Augments the Incidence of Peripheral Blood Suppressive Regulatory T Cells in Nonhuman Primates. In AMERICAN JOURNAL OF TRANSPLANTATION, 19, (p. 427).
  • Yamamoto, T., Hara, H., Foote, J., Klein, E.C., Schuurman, H.J., Wang, L., Li, Q., Zhou, H., Li, J., Tector, J.A., Zhang, Z., Ezzelarab, M., Lovingood, R., Ayares, D., Eckhoff, D.E., Cooper, D.K., & Iwase, H. (2019). Kidney Xenotransplantation from Genetically Engineered Pigs to Baboons with FDA-Approved Immunosuppressive Therapy. In AMERICAN JOURNAL OF TRANSPLANTATION, 19, (pp. 431-432).
  • Yamamoto, T., Hara, H., Foote, J., Wang, L., Li, Q., Klein, E.C., Schuurman, H.J., Ezzelarab, M., Ayares, D., Eckhoff, D.E., Cooper, D.K.C., & Iwase, H. (2019). Survival of genetically-engineered pig kidney grafts in baboons: a comparison of FDA-approved and anti-CD40mAb-based immunosuppressive regimens. In XENOTRANSPLANTATION, 26(5).
  • Elgendy, T., Kim, D., Zahorchak, A., Ezzelarab, M., Solari, M., & Thomson, A. (2018). Comparative Analysis of Bone Marrow versus Blood Monocyte-Derived Regulatory Dendritic Cells for Evaluation in a Miniature Swine Vascular Composite Allotransplantation Model. In AMERICAN JOURNAL OF TRANSPLANTATION, 18, (p. 766).
  • Ezzelarab, M., Hong, Z., Zahorchak, A., Lien, L., Nakao, T., Dai, H., van der Windt, D., Perez-Gutierrez, A., Bhama, J., & Thomson, A. (2018). Persistence and Homing of Autologous Donor-Reactive Ex-Vivo Expanded Regulatory T Cells to Heart Allografts in Lymphodepleted Recipient Monkeys. In AMERICAN JOURNAL OF TRANSPLANTATION, 18, (p. 901).
  • Perez-Gutierrez, A., Metes, D., Hariharan, S., Thomson, A., & Ezzelarab, M. (2018). Donor Reactive Eomesderminhi CD8+ T Cells Are Significantly Upregulated Early after Transplant in Kidney Transplant Patients without Rejection. In AMERICAN JOURNAL OF TRANSPLANTATION, 18, (pp. 402-403).
  • Ezzelarab, M. (2017). Regulatory T cells: From allo to xeno. In XENOTRANSPLANTATION, 24(5).
  • Gao, B., Long, C., Lee, W., Zhang, Z., Gao, X., Landsittel, D., Ezzelarab, M., Ayares, D., Huang, Y., Cooper, D.K.C., Wang, Y., & Hara, H. (2017). Variables in the levels of anti-nonGal/nonNeu5Gc antibodies in healthy humans. In XENOTRANSPLANTATION, 24(5).
  • Iwase, H., Hara, H., Ezzelarab, M., Li, T., Zhang, Z., Gao, B., Liu, H., Long, C., Wang, Y., Cassano, A., Klein, E., Phelps, C., Ayares, D., Humar, A., Wijkstrom, M., & Cooper, D.K.C. (2017). Physiologic observations in baboons with life-supporting pig kidney grafts. In XENOTRANSPLANTATION, 24(5).
  • Iwase, H., Li, T., Lee, W., Hara, H., Long, C., Ezzelarab, M., Ayares, D., Huang, H., Wang, Y., Esmon, C.T., & Cooper, D.K.C. (2017). An evaluation of extracellular histones and inflammation associated markers in pig-to-baboon xenotransplantation. In XENOTRANSPLANTATION, 24(5).
  • Perez-Gutierrez, A., Metes, D., Ono, Y., Thomson, A., & Ezzelarab, M. (2017). High Eomesodermin Expression Correlates with Potent Human Allo-Reactive CD8+ Effector T Cells. In AMERICAN JOURNAL OF TRANSPLANTATION, 17, (p. 719).
  • Perez-Gutierrez, A., Metes, D.M., Thomson, A.W., & Ezzelarab, M.B. (2017). High Eomesodermin Expression Correlates With Human and Non-Human Primate Alloreactive Effector CD8+T Cells. In TRANSPLANTATION, 101(5), (pp. S5-S6).Wolters Kluwer. doi: 10.1097/01.tp.0000520298.13274.d8.
  • Thomson, A., Zahorchak, A., Perez-Gutierrez, A., & Ezzelarab, M. (2017). Generation of Potent Monocytic Myeloid-Derived Suppressor Cells from Rhesus Macaque Bone Marrow. In AMERICAN JOURNAL OF TRANSPLANTATION, 17, (p. 713).
  • Zhang, Z., Hara, H., Long, C., Hayato, I., Qi, H., Macedo, C., Mangiola, M., Zeevi, A., Ezzelarab, M., Ayares, D., Cooper, D.K.C., & Wijkstrom, M. (2017). In vitro immune responses of HLA highly-sensitized AND non-sensitized patients to genetically-engineered pig cells. In XENOTRANSPLANTATION, 24(5).
  • Ezzelarab, M., Zhang, H., Lu, L., Guo, H., Zahorchak, A., Wiseman, R., Nalesnik, M., Bhama, J., Cooper, D., & Thomson, A. (2016). Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients. In AMERICAN JOURNAL OF TRANSPLANTATION, 16, (p. 263).
  • Perez-Gutierrez, A., Lu, L., Zahorchak, A., Ono, Y., Thomson, A., & Ezzelarab, M. (2016). Eomesodermin Expression by CD8+Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients. In AMERICAN JOURNAL OF TRANSPLANTATION, 16, (p. 506).
  • Zhang, H., Zhao, Y., Lu, L., Tang, Q., Ezzelarab, M., & Thomson, A. (2016). Ex Vivo Expansion of Human Alloantigen-Reactive Regulatory T Cells Using Monocyte-Derived Dendritic Cells versus CD40L-Stimulated B Cells. In AMERICAN JOURNAL OF TRANSPLANTATION, 16, (p. 415).
  • Zhang, H., Zhao, Y., Tang, Q., Ezzelarab, M., & Thomson, A. (2016). Ex-vivo expansion of human alloantigen-reactive regulatory T cells using monocyte-derived dendritic cells versus CD40L-stimulated B cells. In TRANSPLANTATION, 100(7), (pp. S283-S284).
  • Ezzelarab, M.B., Isse, K., Ekser, B., Ayares, D., & Cooper, D. (2012). Systemic Inflammation in Xenograft Recipients (SIXR) Precedes Activation of Coagulation in the Presence of T Cell-Directed Immunosuppression. In TRANSPLANTATION, 94(10), (p. 69).Wolters Kluwer. doi: 10.1097/00007890-201211271-00127.
  • Lin, C., Ekser, B., Gridelli, B., Long, C., Echeverri, G., Hara, H., Ezzelarab, M., Ayares, D., Dorling, A., & Cooper, D.K.C. (2009). Tissue factor expression on recipient platelets and PBMCs is the key factor in coagulation dysfunction in pig-to-primate liver transplantation. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 7, (p. 340).
Research Interests
Clinical sciences Immunology Cardiovascular medicine and haematology Biochemistry and cell biology Medical biotechnology Reproductive medicine
headshot of Mohamed Ezzelarab
Contact Mohamed Ezzelarab
Research Professor
Bioengineering Department
mbe8@pitt.edu