Justin Weinbaum

Ph.D., Molecular Cell Biology, Washington University in St. Louis, 2001 - 2007

B.S., Molecular Biophysics and Biochemistry, Yale University, 1996 - 2000

Lorentz, K.L., Marini, A.X., Bruk, L.A., Gupta, P., Mandal, B.B., Dileo, M.V., Weinbaum, J.S., Little, S.R., & Vorp, D.A. (2024). Mesenchymal Stem Cell-Conditioned Media-Loaded Microparticles Enhance Acute Patency in Silk-Based Vascular Grafts. BIOENGINEERING-BASEL, 11(9), 947.MDPI. doi: 10.3390/bioengineering11090947.

Gueldner, P.H., Marini, A.X., Li, B., Darvish, C.J., Chung, T.K., Weinbaum, J.S., Curci, J.A., & Vorp, D.A. (2023). Mechanical and matrix effects of short and long-duration exposure to beta-aminopropionitrile in elastase-induced model abdominal aortic aneurysm in mice. JVS Vascular Science, 4, 100098.Elsevier. doi: 10.1016/j.jvssci.2023.100098.

Nerger, B.A., Jones, T.M., Rose, K.W.J., Barque, A., Weinbaum, J.S., Petrie, R.J., Chang, J., Vanhoutte, D., LaDuca, K., Hubmacher, D., & Naba, A. (2022). The matrix in focus: new directions in extracellular matrix research from the 2021 ASMB hybrid meeting. BIOLOGY OPEN, 11(1), bio059156.The Company of Biologists. doi: 10.1242/bio.059156.

Cunnane, E.M., Davis, N.F., Cunnane, C.V., Lorentz, K.L., Ryan, A.J., Hess, J., Weinbaum, J.S., Walsh, M.T., O'Brien, F.J., & Vorp, D.A. (2021). Mechanical, compositional and morphological characterisation of the human male urethra for the development of a biomimetic tissue engineered urethral scaffold. BIOMATERIALS, 269, 120651.Elsevier. doi: 10.1016/j.biomaterials.2021.120651.

Cunnane, E.M., Ramaswamy, A.K., Lorentz, K.L., Vorp, D.A., & Weinbaum, J.S. (2021). Extracellular Vesicles Derived from Primary Adipose Stromal Cells Induce Elastin and Collagen Deposition by Smooth Muscle Cells within 3D Fibrin Gel Culture. BIOENGINEERING-BASEL, 8(5), 51.MDPI. doi: 10.3390/bioengineering8050051.

Lorentz, K.L., Gupta, P., Shehabeldin, M.S., Cunnane, E.M., Ramaswamy, A.K., Verdelis, K., Dileo, M.V., Little, S.R., Weinbaum, J.S., Sfeir, C.S., Mandal, B.B., & Vorp, D.A. (2021). CCL2 loaded microparticles promote acute patency in silk-based vascular grafts implanted in rat aortae. ACTA BIOMATERIALIA, 135, 126-138.Elsevier. doi: 10.1016/j.actbio.2021.08.049.

Cunnane, E.M., Lorentz, K.L., Ramaswamy, A.K., Gupta, P., Mandal, B.B., O'Brien, F.J., Weinbaum, J.S., & Vorp, D.A. (2020). Extracellular Vesicles Enhance the Remodeling of Cell-Free Silk Vascular Scaffolds in Rat Aortae. ACS APPLIED MATERIALS & INTERFACES, 12(24), 26955-26965.American Chemical Society (ACS). doi: 10.1021/acsami.0c06609.

Cunnane, E.M., Lorentz, K.L., Soletti, L., Ramaswamy, A.K., Chung, T.K., Haskett, D.G., Luketich, S.K., Tzeng, E., D'Amore, A., Wagner, W.R., Weinbaum, J.S., & Vorp, D.A. (2020). Development of a Semi-Automated, Bulk Seeding Device for Large Animal Model Implantation of Tissue Engineered Vascular Grafts. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 8, 597847.Frontiers. doi: 10.3389/fbioe.2020.597847.

Gupta, P., Lorentz, K.L., Haskett, D.G., Cunnane, E.M., Ramaswamy, A.K., Weinbaum, J.S., Vorp, D.A., & Mandal, B.B. (2020). Bioresorbable silk grafts for small diameter vascular tissue engineering applications: In vitro and in vivo functional analysis. ACTA BIOMATERIALIA, 105, 146-158.Elsevier. doi: 10.1016/j.actbio.2020.01.020.

Ramaswamy, A.K., Sides, R.E., Cunnane, E.M., Lorentz, K.L., Reines, L.M., Vorp, D.A., & Weinbaum, J.S. (2019). Adipose-derived stromal cell secreted factors induce the elastogenesis cascade within 3D aortic smooth muscle cell constructs. Matrix Biology Plus, 4, 100014.Elsevier. doi: 10.1016/j.mbplus.2019.100014.

Ramaswamy, A.K., Vorp, D.A., & Weinbaum, J.S. (2019). Functional Vascular Tissue Engineering Inspired by Matricellular Proteins. FRONTIERS IN CARDIOVASCULAR MEDICINE, 6, 74.Frontiers. doi: 10.3389/fcvm.2019.00074.

Cunnane, E.M., Weinbaum, J.S., O'Brien, F.J., & Vorp, D.A. (2018). Future Perspectives on the Role of Stem Cells and Extracellular Vesicles in Vascular Tissue Regeneration. FRONTIERS IN CARDIOVASCULAR MEDICINE, 5, 86.Frontiers. doi: 10.3389/fcvm.2018.00086.

Haskett, D.G., Saleh, K.S., Lorentz, K.L., Josowitz, A.D., Luketich, S.K., Weinbaum, J.S., Kokai, L.E., D'Amore, A., Marra, K.G., Rubin, J.P., Wagner, W.R., & Vorp, D.A. (2018). An exploratory study on the preparation and evaluation of a "same-day'' adipose stem cell-based tissue-engineered vascular graft. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 156(5), 1814-+.Elsevier. doi: 10.1016/j.jtcvs.2018.05.120.

Cheheltani, R., Pichamuthu, J.E., Rao, J., Weinbaum, J.S., Kiani, M.F., Vorp, D.A., & Pleshko, N. (2017). Fourier Transform Infrared Spectroscopic Imaging-Derived Collagen Content and Maturity Correlates with Stress in the Aortic Wall of Abdominal Aortic Aneurysm Patients. CARDIOVASCULAR ENGINEERING AND TECHNOLOGY, 8(1), 70-80.Springer Nature. doi: 10.1007/s13239-016-0289-3.

Krawiec, J.T., Liao, H.T., Kwan, L.L., D'Amore, A., Weinbaum, J.S., Rubin, J.P., Wagner, W.R., & Vorp, D.A. (2017). Evaluation of the stromal vascular fraction of adipose tissue as the basis for a stem cell-based tissue-engineered vascular graft. JOURNAL OF VASCULAR SURGERY, 66(3), 883-+.Elsevier. doi: 10.1016/j.jvs.2016.09.034.

Blose, K.J., Pichamuthu, J.E., Weinbaum, J.S., & Vorp, D.A. (2016). Design and Validation of a Vacuum Assisted Anchorage for the Uniaxial Tensile Testing of Soft Materials. Soft Mater, 14(2), 72-77.Taylor & Francis. doi: 10.1080/1539445X.2016.1141787.

Krawiec, J.T., Weinbaum, J.S., Liao, H.T., Ramaswamy, A.K., Pezzone, D.J., Josowitz, A.D., D'Amore, A., Rubin, J.P., Wagner, W.R., & Vorp, D.A. (2016). In Vivo Functional Evaluation of Tissue-Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High Cardiovascular Risk Populations. TISSUE ENGINEERING PART A, 22(9-10), 765-775.Mary Ann Liebert. doi: 10.1089/ten.tea.2015.0379.

Krawiec, J.T., Weinbaum, J.S., St Croix, C.M., Phillippi, J.A., Watkins, S.C., Rubin, J.P., & Vorp, D.A. (2015). A Cautionary Tale for Autologous Vascular Tissue Engineering: Impact of Human Demographics on the Ability of Adipose-Derived Mesenchymal Stem Cells to Recruit and Differentiate into Smooth Muscle Cells. TISSUE ENGINEERING PART A, 21(3-4), 426-437.Mary Ann Liebert. doi: 10.1089/ten.tea.2014.0208.

Rao, J., Brown, B.N., Weinbaum, J.S., Ofstun, E.L., Makaroun, M.S., Humphrey, J.D., & Vorp, D.A. (2015). Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm. JOURNAL OF VASCULAR SURGERY, 62(3), 585-593.Elsevier. doi: 10.1016/j.jvs.2014.11.086.

Blose, K.J., Ennis, T.L., Arif, B., Weinbaum, J.S., Curci, J.A., & Vorp, D.A. (2014). Periadventitial adipose-derived stem cell treatment halts elastase-induced abdominal aortic aneurysm progression. REGENERATIVE MEDICINE, 9(6), 733-741.Taylor & Francis. doi: 10.2217/RME.14.61.

Blose, K.J., Krawiec, J.T., Weinbaum, J.S., & Vorp, D.A. (2014). Bioreactors for Tissue Engineering Purposes. In Regenerative Medicine Applications in Organ Transplantation. (pp. 177-185).Elsevier. doi: 10.1016/b978-0-12-398523-1.00013-6.

Blose, K.J., Krawiec, J.T., Weinbaum, J.S., & Vorp, D.A. (2014). Chapter 13 Bioreactors for Tissue Engineering Purposes. In Regenerative Medicine Applications in Organ Transplantation. (pp. 177-185).Elsevier. doi: 10.1016/b978-0-12-398523-1.00013-6.

Krawiec, J.T., Bruce, K., Josowitz, A., Kokai, L., D'Amore, A., Weinbaum, J., Wagner, W., Rubin, P., & Vorp, D. (2014). Evaluating cells from liposuction aspirates for vascular tissue engineering. ANGIOGENESIS, 17, (p. 306).Hyannis, MA.

Blose, K.J., Krawiec, J.T., Weinbaum, J.S., & Vorp, D.A. (2013). Bioreactors for Tissue Engineering Purposes; Chapter 15. (pp. 201-210).Academic Press.

Weinbaum, J.S., Schmidt, J.B., & Tranquillo, R.T. (2013). Combating Adaptation to Cyclic Stretching by Prolonging Activation of Extracellular Signal-Regulated Kinase. CELLULAR AND MOLECULAR BIOENGINEERING, 6(3), 279-286.Springer Nature. doi: 10.1007/s12195-013-0289-4.

Ahmann, K.A., Weinbaum, J.S., Johnson, S.L., & Tranquillo, R.T. (2010). Fibrin Degradation Enhances Vascular Smooth Muscle Cell Proliferation and Matrix Deposition in Fibrin-Based Tissue Constructs Fabricated In Vitro. TISSUE ENGINEERING PART A, 16(10), 3261-3270.Mary Ann Liebert. doi: 10.1089/ten.tea.2009.0708.

Craft, C.S., Zou, W., Watkins, M., Grimston, S., Brodt, M.D., Broekelmann, T.J., Weinbaum, J.S., Teitelbaum, S.L., Pierce, R.A., Civitelli, R., Silva, M.J., & Mecham, R.P. (2010). Microfibril-associated Glycoprotein-1, an Extracellular Matrix Regulator of Bone Remodeling. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(31), 23858-23867.Elsevier. doi: 10.1074/jbc.M110.113019.

Weinbaum, J.S., Qi, J., & Tranquillo, R.T. (2010). Monitoring Collagen Transcription by Vascular Smooth Muscle Cells in Fibrin-Based Tissue Constructs. TISSUE ENGINEERING PART C-METHODS, 16(3), 459-467.Mary Ann Liebert. doi: 10.1089/ten.tec.2009.0112.

Weinbaum, J.S., Tranquillo, R.T., & Mecham, R.P. (2010). The Matrix-Binding Domain of Microfibril-Associated Glycoprotein-1 Targets Active Connective Tissue Growth Factor to a Fibroblast-Produced Extracellular Matrix. MACROMOLECULAR BIOSCIENCE, 10(11), 1338-1344.Wiley. doi: 10.1002/mabi.201000121.

Black, L.D.I.I.I., Meyers, J.D., Weinbaum, J.S., Shvelidze, Y.A., & Tranquillo, R.T. (2009). Cell-Induced Alignment Augments Twitch Force in Fibrin Gel-Based Engineered Myocardium via Gap Junction Modification. TISSUE ENGINEERING PART A, 15(10), 3099-3108.Mary Ann Liebert. doi: 10.1089/ten.tea.2008.0502.

Syedain, Z.H., Weinberg, J.S., & Tranquillo, R.T. (2008). Cyclic distension of fibrin-based tissue constructs: Evidence of adaptation during growth of engineered connective tissue. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(18), 6537-6542.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0711217105.

Weinbaum, J.S., Broekelmann, T.J., Pierce, R.A., Werneck, C.C., Segade, F., Craft, C.S., Knutsen, R.H., & Mecham, R.P. (2008). Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(37), 25533-25543.Elsevier. doi: 10.1074/jbc.M709962200.

Werneck, C.C., Vicente, C.P., Weinberg, J.S., Shifren, A., Pierce, R.A., Broekelmann, T.J., Tollefsen, D.M., & Mecham, R.P. (2008). Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. BLOOD, 111(8), 4137-4144.American Society of Hematology. doi: 10.1182/blood-2007-07-101733.

Estacion, M., Weinberg, J.S., Sinkins, W.G., & Schilling, W.P. (2003). Blockade of maitotoxin-induced endothelial cell lysis by glycine and L-alanine. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 284(4), C1006-C1020.American Physiological Society. doi: 10.1152/ajpcell.00258.2002.

Deverman, B.E., Cook, B.L., Manson, S.R., Niederhoff, R.A., Langer, E.M., Rosová, I., Kulans, L.A., Fu, X.Y., Weinberg, J.S., Heinecke, J.W., Roth, K.A., & Weintraub, S.J. (2002). Bcl-X_L deamidation is a critical switch in the regulation of the response to DNA damage. CELL, 111(1), 51-62.Elsevier. doi: 10.1016/S0092-8674(02)00972-8.

Wankhade, S., Yu, Y.H., Weinberg, J., Tainsky, M.A., & Kannan, P. (2000). Characterization of the activation domains of AP-2 family transcription factors. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(38), 29701-29708.Elsevier. doi: 10.1074/jbc.M000931200.

Weinbaum, J.S. (2015). Methods for Monitoring New Elastin Formation During Elastogenic Therapy. In TISSUE ENGINEERING PART A, 21, (pp. S375-S376).

Weinbaum, J., Schmidt, J., & Tranquillo, R. (2012). Combating adaptation to stretch conditioning through prolonged activation of extracellular signal-regulated kinase. American Society for Matrix Biology.San Diego, CA.

Pierce, R.A., Craft, C.S., Weinbaum, J.S., Broekelmann, T., & Mecham, R.P. (2009). Microfibril-associated glycoprotein-1 binds multiple active TGF-beta family members, affecting homeostasis in multiple organ systems. In FASEB JOURNAL, 23.