Balius, T., Eiseman, J.L., Soni, A.S., and Parker, R.S., "A Mathematical Tool for Analyzing Two-Drug Chemotherapy," Comput. Biol. Med., Manuscript submitted for publication.
Ho, T., Clermont, G., and Parker, R.S., "Mathematical Model of Neutrophil Dynamics and Responses in Inflammation Challenge and Cancer Treatment," Computers and Chemical Engineering, Manuscript submitted for publication.
Hogg, J.S., Knab, T., Rimmele, T., Valenti, I.E., Fedorchak, M.V., Federspiel, W.J., Kellum, J.A., Clermont, G., and Parker, R.S., "Modeling and Treatment of Acute Inflammation Part II: Model-Based control of Blood Purification," J. Process Control, Manuscript submitted for publication.
Roy, A., Daun-Gruhn, S., Clermont, G., Rubin, J., Vodovotz, Y., Lagoa, C., and Parker, R.S., "Modeling and Treatment of Acute Inflammation, Part I: A Mathematical Model of Acute Inflammatory Response to Endotoxin Challenge," J. Process Control, Manuscript submitted for publication.
Ho, T., Clermont, G., and Parker, R.S., 2012, "Modeling Neutrophil Dynamics in Sepsis and Cancer Treatment," CPC 8, Savannah, GA.
Song, S.O., Hogg, J., Peng, Z.Y., Parker, R.S., Kellum, J.A., and Clermont, G., 2012, "Ensemble Models of Neutrophil Trafficking in Severe Sepsis," PLoS Computational Biology, no.3, e1002422.
Battaglia, M.A., and Parker, R.S., 2011, "PK/PD Modeling of Intracellular Gemcitabine Triphosphate Accumulation: Translating in vitro to in vivo," IET Systems Biology Special Issue from the Third International Conference on Foundations of Systems Biology in Engineering, no.1, pp. 34-43.
Kimmel, J.D., Harbert, E.M., Parker, R.S., and Federspiel, W.J., 2011, "Modeling Competitive Cytokine Adsorption Dynamics Within Hemoadsorption Beads Used to Treat Sepsis," J. Chromatography A, no.44, pp. 8013-8020.
Kotchey, N.M., Adachi, K., Zahid, M., Inagaki, K., Charan, R., Parker, R.S., and Nakai, H., 2011, "A Potential Role of Distinctively Delayed Blood Clearance of Recombinant Adeno-Associated Virus Serotype 9 in robust cardiac transduction," Molecular Therapy, no.6, pp. 1079-1089.
McCarthy, J.J., Parker, R.S., Abatan, A.A., and Besterfield-Sacre, M., 2011, "Building an Evaluation Strategy for an Integrated Curriculum in Chemical Engineering," Advances in Engineering Education, no.4.
Parker, R.S., and Clermont, G., 2010, "Systems Engineering Medicine: Engineering the Inflammation Response to Infectious Traumatic Challenges," J. Royal Soc. Interface, no.48, pp. 989-1013, 10.1098/rsif.2009.0517.
Hogg, J.S., Clermont, G., and Parker, R.S., 2010, "Acute Inflammation Treatment via Particle Filter State Estimation and MPC," DYCOPS 2010, Leuven, Belgium.
Roy, A., and Parker, R.S., 2010, "A Phenomenological Model of Plasma FFA, Glucose, and Insulin Concentrations During Rest and Exercise," American Control Conference, Baltimore, MD.
Parker, R.S., 2009, "Automation and Control in Biomedical Systems; Section H, Chapter 76," in Handbook of Automation, S.Y. Nof, ed., Springer, pp. 1361-1378.
Harrold, J.M., and Parker, R.S., 2009, "Clinically Relevant Cancer Chemotherapy dose Scheduling via Mixed-Integer Optimization," Computers & Chemical Engineering, FOCAPO 2008 Special Issue, no.12, pp. 2042-2054, 10.1016/j.compchemeng.2009.06.005.
Jr., M.A., and Parker, R.S., 2009, "Pk/PD Modeling of Intracellular Gemcitabine Triphosphate Accumulation: Translating in vitro to in vivo," Foundations of Systems Biology in Engineering 2009, Denver, CO.
Beumer, J.H., Eiseman, J.L., Parise, R.A., Jr., J.A., Joseph, E., D'Argenio, D.Z., Parker, R.S., Kay, B., Covey, J.M., and Egorin, M.J., 2008, "Plasma Pharmacokinetics and Oral Bioavailability of 3,4,5,6-Tetrahydrouridine (THU), a Cytidine Deaminase Inhibitor, in Mice," Cancer Chemotherapy and Pharmacology, no.3, pp. 457-464.
Daun, S., Rubin, J., Vodovotz, Y., Roy, A., Parker, R.S., and Clermont, G., 2008, "An Ensemble of Models of the Acute Inflammatory Response to Bacterial Lipopolysaccharide in Rats: Results from Parameter Space Reduction," J. Theoretical Bio., no.4, pp. 843-853.
Jr., J.A., Eiseman, J.L., and Parker, R.S., 2008, "Nonlinear Model Predictive Control for Dosing Daily Anticancer Agents: A Tamoxifen Treatment of Breast Cancer Case Study," Comput. Biol. Med., pp. 339-347.
Kanick, S.C., and Parker, R.S., 2008, "In silico Analysis of Photodynamic Therapy Dosimetry Using the Optical Pharmacokinetic System," SPIE - Photonics West, San Jose, CA.
Kanick, S.C., Eiseman, J.L., and Parker, R.S., 2008, "Pharmacokinetic Modeling of MGd Disposition in Mouse Tissues using Optical Pharmacokinetic System Measurements," Photodiagnosis and Photodynamic Therapy, no.4, pp. 276-284.
Doyle III, F.J., Seborg, D., Parker, R.S., Bequette, B.W., Jeffrey, A., Xia, X., Craig, I., and McAvoy, T.J., 2007, "A Tutorial on Biomedical Process Control," J. Process Control, no.7, pp. 571-594.
Florian Jr., J.A., and Parker, R.S., 2007, "Modeling Gemcitabine Triphosphate Production in Peripheral Blood Mononuclear Cells Following Intravenous Gemcitabine Administration," Foundations of Systems Biology in Engineering 2007, Stuttgart, Germany.
Jr., J.A., and Parker, R.S., 2007, "Feedback Control in Drug Delivery; Chapter 2," in Nanotechnology in Therapeutics: Current Technology and Applications, J.Z. Hilt, N.A. Peppas, and J.B. Thomas, eds., Horizon Bioscience, Norwich, UK.
Kanick, S.C., and Parker, R.S., 2007, "Monte-Carlo of Elastic Scattering Spectroscopic Measurement using the Optical Pharmacokinetic System (OPS)," SPIE - Photonics West, San Jose, CA.
Kanick, S.C., Eiseman, J.L., Joseph, E., Guo, J., and Parker, R.S., 2007, "Non-invasive Optical Spectroscopic Measurement of Motexafin Gadolinium in Murine Tissues: Comparison to High-Performance Liquid Chromatography," J. Photochemistry and Photobiology B: Biology, pp. 90-104.
McCarthy, J.J., Parker, R.S., and Besterfield-Sacre, M., 2007, "Chemical Engineering Curricular Redesign at the University of Pittsburgh," ASEE Annual Conference, Honolulu, HI.
Roy, A., and Parker, R.S., 2007, "Dynamic Modeling of Exercise Effects on Plasma Glucose and Insulin Levels," J. Diabetes Science and Technology, no.3, pp. 338-347.
Soni, A.S., and Parker, R.S., 2007, "Tailored Input Sequence Design for Third-Order Volterra Model Identification," Ind. & Eng. Chem. Res., no.3, pp. 818-829.
Parker, R.S., Doyle III, F.J., and Henson, M.A., 2006, "Integrating Biological Systems Content in the Process Dynamics and Control Curriculum," Chemical Engineering Education, no.3, pp. 181-188.
Antoine, A.L., and Parker, R.S., 2006, "An Analytical Solution to Multivariable Nonlinear MPC for Second-Order Laguerre Systems," ADCHEM '06, Gramado, Brazil.
Beumer, J.H., Joseph, E., Egorin, M.J., Parker, R.S., D;Argenio, D.Z., Covey, J.M., and Eiseman, J.L., 2006, "A Mass Balance and Disposition Study of the DNA-methyltransferase Inhibitor Zebularine (NSC 309132) and Three of its Metabolites in Mice," Clinical Cancer Res., no.19, pp. 5826-5833.
Harrold, J.M., and Parker, R.S., 2006, "Clinically-Relevant Cancer Chemotherapy Treatment Scheduling using Parameterized Mixed-Integer Programming," Chemical Process Control 7, Lake Louise, Alberta, Canada.
Roy, A., and Parker, R.S., 2006, "Dynamic Modeling of Exercise Effects on Plasma Glucose and Insulin Levels," ADCHEM 2006, Gramado, Brazil.
Roy, A., and Parker, R.S., 2006, "Dynamic Modeling of Free Fatty Acids, glucose, and Insulin: An Extended Minimal Model," Diabetes Technology and Therapeutics, no.6, pp. 617-626.
Roy, A., and Parker, R.S., 2006, "Mixed Meal Modeling and Disturbance Rejection in Type I Diabetic Patients," 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, New York, NY.
Barone, P.W., Parker, R.S., and Strano, M.S., 2005, "In-Vivo Fluorescence Detection of glucose using a Single Walled Carbon Nanotube Optical Sensor: Design, Fluorophore Properties, Advantages, and Disadvantages," Analytical Chemistry, no.23, pp. 7556-7562.
Florian Jr., J.A., and Parker, R.S., 2005, "A Population Balance Model of Cell Cycle-Specific Tumor Growth," 16th IFAC World Congress on Automatic Control, Prague, Czech Republic.
Florian Jr., J.A., and Parker, R.S., 2005, "Empirical Modeling for Glucose Control in Diabetes and Critical Care," European Journal of Control, Special Section on Automatic Drug Delivery for Anesthesia and Critical Care, no.6, pp. 601-616.
Florian Jr., J.A., Eiseman, J.L., and Parker, R.S., 2005, "Modeling Quiescent Cells in Tumor Growth and Cancer Treatment," Foundations of Systems Biology in Engineering, Santa Barbara, CA.
Florian, J.A., Eiseman, J.L., and Parker, R.S., 2005, "Accounting for Quiescent Cells in Tumor Growth and Cancer Treatment," FOSBE Conference Special Issue of IEE Systems Biology, pp. 185-192.
Harrold, J.M., Zamboni, W.C., and Eiseman, J.L., 2005, "A Pharmacokinetic / Pharmacodynamic Model of 9-Nitrocamptothecin in SCID Mice," J. Pharmacokinetics and Pharmacodynamics, no.1, pp. 65-83.
Soni, A.S., and Parker, R.S., 2005, "Efficient Input Signal Design for Third-Order Volterra Model Identification," 16th IFAC World Congress on Automatic Control, Prague, Czech Republic.
Parker, R.S., 2004, "Insulin Delivery," in Encyclopedia of Biomaterials and Biomedical Engineering, G. Bowlin, and G. Wnek, eds., Marcell Dekker, Inc., pp. 857-866, New York.
Parker, R.S., Doyle III, F.J., and Henson, M.A., 2004, "Integration of Biological Systems Content into the Process Dynamics and Control Curriculum," DYCOPS 7, Cambridge, MA.
Parker, R.S., Harrold, J.M., Eiseman, J.L., Zamboni, W.C., Joseph, E., Strychor, S., and Egorin, M.J., 2004, "Toward Model-Based Chemotherapy Treatment Design," in Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, Volume III, D.Z. D'Argenio, ed., Kluwer Academic Publishers, pp. 255-274, Norwell, MA.
Florian Jr., J.A., Eiseman, J.L., and Parker, R.S., 2004, "A Nonlinear Model Predictive Control Algorithm for Breast Cancer Treatment," DYCOPS 7, Cambridge, MA.
Harrold, J.M., and Parker, R.S., 2004, "Comparative Analysis of Chemotherapy Dose Scheduling Design Methodologies," American Control Conference, Boston, MA.
McCarthy, J.J., and Parker, R.S., 2004, "The Pillars of Chemical Engineering: A Block Scheduled Curriculum," Chemical Engineering Education, no.4, pp. 292-301.
Soni, A.S., and Parker, R.S., 2004, "Closed-Loop Control of Fed-Batch Bioreactors: A Shrinking-Horizon Approach," Ind. & Eng. Chem. Res., pp. 3381-3393.
Soni, A.S., and Parker, R.S., 2004, "Control-Relevant Identification for Third-Order Volterra Systems: A Polymerization Case Study," American Control Conference, Boston, MA.
Asoor, A.B., Muske, K.R., Kelly, W.J., and Parker, R.S., 2003, "Dynamic Cellular Modeling for Continuous Fermentation," American Control Conference, Denver, CO.
Komives, C., and Parker, R.S., 2003, "Bioreactor State Estimation and Control," Current Opinions in Biotechnology, pp. 468-474.
Rubb, J.D., and Parker, R.S., 2003, "Glucose Control in Type I Diabetic Patients: A Volterra Model-Based Approach," ADCHEM '03, Hong Kong, China.
Soni, A.S., and Parker, R.S., 2003, "Fed-Batch Bioreactor Control using Multi-Scale Models," American Control Conference, Denver, CO.
Parker, R.S., 2002, "Nonlinear Model Predictive Control of a Continuous Bioreactor Using Approximate Data-Driven Models," American Control Conference, Anchorage, AL.
Florian Jr., J.A., and Parker, R.S., 2002, "A Nonlinear Data-Driven Approach to Type I Diabetic Patient Modeling," 15th IFAC World Congress on Automatic Control, Barcelona, Spain.
Lenart, P.J., and Parker, R.S., 2002, "Modeling Exercise Effects in Type I Diabetic Patients," 15th IFAC World Congress on Automatic Control, Barcelona, Spain.
Parker, R.S., 2001, "Efficient Nonlinear Model Predictive Control: Exploiting the Volterra-Laguerre Model Structure," CPC 6, pp. 418-422, Tucson, AZ.
Parker, R.S., and Doyle III, F.J., 2001, "Control-relevant Modeling in Drug Delivery," Advances in Drug Delivery Reviews, pp. 211-248.
Parker, R.S., and Doyle III, F.J., 2001, "Optimal Control of a Continuous Bioreactor Using an Empirical Nonlinear Model," Ind. & Eng. Chem. Res., no.8, pp. 1939-1951.
Parker, R.S., Doyle III, F.J., and Peppas, N.A., 2001, "Blood Glucose Control in Diabetic Patients using the Intravenous Route," IEEE Eng. Med. Biol., no.1, pp. 65-73.
Parker, R.S., Gatzke, E.P., Mahadevan, R., Meadows, E.S., and Doyle III, F.J., 2001, "Nonlinear Model Predictive Control: Issues and Applications," in Advances in Non-Linear Model Predictive Control, M. Cannon, and B. Kouvaritakis, eds., IEE Publishing, p. 272, London, UK.
Parker, R.S., Heemstra, D.H., Doyle III, F.J., Pearson, R.K., and Ogunnaike, B.A., 2001, "The Identification of Nonlinear Models for Process Control Using Tailored "Plant-Friendly" Input Sequences," J. Proc. Control Sp. Iss. SI, no.2, pp. 237-250.
Lenart, P.J., and Parker, R.S., 2001, "Glucose Control During Exercise in Type I Diabetic Patients," Topical Conference on Bioinformatics and Genomics at the AIChE Annual Meeting, Reno, NV.
Parker, R.S., Gatzke, E.P., and Doyle III, F.J., 2000, "Advanced Model Predictive Control (MPC) for Diabetic Patient Blood Glucose Control," American Control Conference, Chicago, IL.
Parker, R.S., Ward, J.H., Doyle III, F.J., and Peppas, N.A., 2000, "Robust H1 Glucose Control in Diabetes Using a Physiological Model.," AIChE Journal, no.12, pp. 2537-2549.
Doyle III, F.J., Gatzke, E.P., and Parker, R.S., 2000, "Process Control Modules: A Software Laboratory for Control Design," Prentice Hall PTR, New Jersey.
Rengasamy, R., Parker, R.S., and Doyle III, F.J., 2000, "Issues in Design of Input Signals for the Identification of Nonlinear Models of Process Systems," ADCHEM '00, Pisa, Italy.
Parker, R.S., Doyle III, F.J., and Peppas, N.A., 1999, "A Model-based Algorithm for Blood Glucose Control in Type I Diabetic Patients," IEEE - Transactions on Biomedical Engineering, no.2, pp. 148-158.
Doyle III, F.J., Parker, R.S., Pearson, R.K., and Ogunnaike, B.A., 1999, "Plant-friendly Identification of Second Order Volterra Models," Fifth European Control Conference, Karlsruhe, Germany.
Parker, R.S., and Doyle III, F.J., 1998, "Nonlinear Model Predictive Control of a Continuous Bioreactor at Near-Optimum Conditions," American Control Conference, pp. 2549-2554, Philadelphia, PA.
Doyle III, F.J., Gatzke, E.P., and Parker, R.S., 1998, "Practical Case Studies for Undergraduate Process Dynamics and Control Using the Process Control Modules (PCM)," Computer Applications in Engineering Education, no.3, pp. 181-191.
Parker, R.S., Doyle III, F.J., Rabinovitch, K.L., and Peppas, N.A., 1997, "time and Frequency Domain Analysis of Blood Glucose Regulation Algorithms," IEEE- Engineering in Medicine and Biology Society 19th Annual International Conference, Chicago, IL.
Parker, R.S., Rabinovitch, K.L., Doyle III, F.J., and Peppas, N.A., 1997, "Control Analysis of Pancreas Models for Optimal Insulin Delivery," Topical Conference on Biomaterials, Carriers for Drug Delivery, and Scaffolds for Tissue Engineering at the AIChE Annual Meeting, Los Angeles, CA.
Parker, R.S., Doyle III, F.J., Harting, J.E., and Peppas, N.A., 1996, "Model Predictive Control for Infusion Pump Insulin Delivery," IEEE- Engineering in Medicine and Biology Society 18th Annual International Conference, Amsterdam, The Netherlands.
Doyle III, F.J., Peppas, N.A., Parker, R.S., Harting, J.E., and Podual, K., 1996, "Robust Model-based Control of Insulin Pumps and Devices," Intern. Symp. Control. Rel. Bioact. Mater., 23, pp. 174-175.