PhD, Biochemistry and Molecular Biology, Shanghai Jiao Tong University
Bachelor of Engineering, Biomedical Engineering, Tianjin Medical University
Wu, K., Ge, X.X., Duan, X.F., Li, J.Q., Wang, K., Chen, Q.H., Huang, Z.M., Zhang, W.Y., Wu, Y., & Li, Q. (2025). Wip1 phosphatase activator QGC-8-52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells. Drug Resist Updat, 79, 101196.Elsevier. doi: 10.1016/j.drup.2024.101196.
Lee, S., Nouraein, S., Kwon, J.J., Huang, Z., Wojick, J.A., Xia, B., Corder, G., & Szablowski, J.O. (2024). Engineered serum markers for non-invasive monitoring of gene expression in the brain. Nat Biotechnol, 42(11), 1717-1725.Springer Nature. doi: 10.1038/s41587-023-02087-x.
Seo, J.P., Trippett, J.S., Huang, Z., Lee, S., Nouraein, S., Wang, R.Z., & Szablowski, J.O. (2024). Acoustically targeted measurement of transgene expression in the brain. Sci Adv, 10(32), eadj7686.American Association for the Advancement of Science (AAAS). doi: 10.1126/sciadv.adj7686.
Hao, Q., Huang, Z., Li, Q., Liu, D., Wang, P., Wang, K., Li, J., Cao, W., Deng, W., Wu, K., Su, R., Liu, Z., Vadgama, J., & Wu, Y. (2022). A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer. Adv Sci (Weinh), 9(6), e2102303.Wiley. doi: 10.1002/advs.202102303.
Zhang, Q., Chen, Y., Ni, D., Huang, Z., Wei, J., Feng, L., Su, J.C., Wei, Y., Ning, S., Yang, X., Zhao, M., Qiu, Y., Song, K., Yu, Z., Xu, J., Li, X., Lin, H., Lu, S., & Zhang, J. (2022). Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells. Acta Pharm Sin B, 12(2), 876-889.Elsevier. doi: 10.1016/j.apsb.2021.06.015.
Huang, Z., Li, Z., Zhang, X., Kang, S., Dong, R., Sun, L., Fu, X., Vaisar, D., Watanabe, K., & Gu, L. (2020). Creating Red Light-Switchable Protein Dimerization Systems as Genetically Encoded Actuators with High Specificity. ACS Synth Biol, 9(12), 3322-3333.American Chemical Society (ACS). doi: 10.1021/acssynbio.0c00397.
Wu, K., Yu, X., Huang, Z., Zhu, D., Yi, X., Wu, Y.L., Hao, Q., Kemp, K.T., Elshimali, Y., Iyer, R., Nguyen, K.T., Zheng, S., Chen, G., Chen, Q.H., Wang, G., Vadgama, J.V., & Wu, Y. (2019). Targeting of PP2Cδ By a Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer Progression In Vivo. Antioxid Redox Signal, 30(17), 1983-1998.Mary Ann Liebert. doi: 10.1089/ars.2017.7486.
Huang, Z., Zhao, J., Deng, W., Chen, Y., Shang, J., Song, K., Zhang, L., Wang, C., Lu, S., Yang, X., He, B., Min, J., Hu, H., Tan, M., Xu, J., Zhang, Q., Zhong, J., Sun, X., Mao, Z., Lin, H., Xiao, M., Chin, Y.E., Jiang, H., Xu, Y., Chen, G., & Zhang, J. (2018). Identification of a cellularly active SIRT6 allosteric activator. Nat Chem Biol, 14(12), 1118-1126.Springer Nature. doi: 10.1038/s41589-018-0150-0.
Huang, M., Chen, Z., Zhang, L., Huang, Z., Chen, Y., Xu, J., Zhang, J., & Shu, X. (2016). Screening and biological evaluation of a novel STAT3 signaling pathway inhibitor against cancer. Bioorg Med Chem Lett, 26(21), 5172-5176.Elsevier. doi: 10.1016/j.bmcl.2016.09.073.
Shen, Q., Wang, G., Li, S., Liu, X., Lu, S., Chen, Z., Song, K., Yan, J., Geng, L., Huang, Z., Huang, W., Chen, G., & Zhang, J. (2016). ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks. Nucleic Acids Res, 44(D1), D527-D535.Oxford University Press (OUP). doi: 10.1093/nar/gkv902.
Wei, W., Ma, C., Cao, Y., Yang, L., Huang, Z., Qin, D., Chen, Y., Liu, C., Xia, L., Wang, T., Lei, H., Yu, Y., Huang, M., Tong, Y., Xu, H., Gao, F., Zhang, J., & Wu, Y.L. (2016). Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells. Oncotarget, 7(4), 3873-3883.Impact Journals. doi: 10.18632/oncotarget.6763.
Huang, W., Wang, G., Shen, Q., Liu, X., Lu, S., Geng, L., Huang, Z., & Zhang, J. (2015). ASBench: benchmarking sets for allosteric discovery. Bioinformatics, 31(15), 2598-2600.Oxford University Press (OUP). doi: 10.1093/bioinformatics/btv169.
Song, F.F., Xia, L.L., Ji, P., Tang, Y.B., Huang, Z.M., Zhu, L., Zhang, J., Wang, J.Q., Zhao, G.P., Ge, H.L., Zhang, Y., & Wang, Y. (2015). Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation. Oncogenesis, 4(6), e159.Springer Nature. doi: 10.1038/oncsis.2015.10.
Huang, Z., Mou, L., Shen, Q., Lu, S., Li, C., Liu, X., Wang, G., Li, S., Geng, L., Liu, Y., Wu, J., Chen, G., & Zhang, J. (2014). ASD v2.0: updated content and novel features focusing on allosteric regulation. Nucleic Acids Res, 42(Database issue), D510-D516.Oxford University Press (OUP). doi: 10.1093/nar/gkt1247.
Huang, M., Lu, S., Shi, T., Zhao, Y., Chen, Y., Li, X., Liu, X., Huang, Z., & Zhang, J. (2013). Conformational transition pathway in the activation process of allosteric glucokinase. In Xue, B. (Ed.). PLoS One, 8(2), e55857.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0055857.
Huang, W., Lu, S., Huang, Z., Liu, X., Mou, L., Luo, Y., Zhao, Y., Liu, Y., Chen, Z., Hou, T., & Zhang, J. (2013). Allosite: a method for predicting allosteric sites. Bioinformatics, 29(18), 2357-2359.Oxford University Press (OUP). doi: 10.1093/bioinformatics/btt399.
Li, X., Chen, Y., Lu, S., Huang, Z., Liu, X., Wang, Q., Shi, T., & Zhang, J. (2013). Toward an understanding of the sequence and structural basis of allosteric proteins. J Mol Graph Model, 40, 30-39.Elsevier. doi: 10.1016/j.jmgm.2012.12.011.
Lu, S.Y., Huang, Z.M., Huang, W.K., Liu, X.Y., Chen, Y.Y., Shi, T., & Zhang, J. (2013). How calcium inhibits the magnesium-dependent kinase gsk3β: a molecular simulation study. Proteins, 81(5), 740-753.Wiley. doi: 10.1002/prot.24221.
Shi, T., Han, Y., Li, W., Zhao, Y., Liu, Y., Huang, Z., Lu, S., & Zhang, J. (2013). Exploring the desumoylation process of SENP1: a study combined MD simulations with QM/MM calculations on SENP1-SUMO1-RanGAP1. J Chem Inf Model, 53(9), 2360-2368.American Chemical Society (ACS). doi: 10.1021/ci4002487.
Chen, Y., Wen, D., Huang, Z., Huang, M., Luo, Y., Liu, B., Lu, H., Wu, Y., Peng, Y., & Zhang, J. (2012). 2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation. Bioorg Med Chem Lett, 22(22), 6867-6870.Elsevier. doi: 10.1016/j.bmcl.2012.09.037.
Duan, X., Block, E., Li, Z., Connelly, T., Zhang, J., Huang, Z., Su, X., Pan, Y., Wu, L., Chi, Q., Thomas, S., Zhang, S., Ma, M., Matsunami, H., Chen, G.Q., & Zhuang, H. (2012). Crucial role of copper in detection of metal-coordinating odorants. Proc Natl Acad Sci U S A, 109(9), 3492-3497.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1111297109.
Huang, Z., Jiang, H., Liu, X., Chen, Y., Wong, J., Wang, Q., Huang, W., Shi, T., & Zhang, J. (2012). HEMD: an integrated tool of human epigenetic enzymes and chemical modulators for therapeutics. In Ballestar, E. (Ed.). PLoS One, 7(6), e39917.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0039917.
Liu, X., Liu, B., Huang, Z., Shi, T., Chen, Y., & Zhang, J. (2012). SPPS: a sequence-based method for predicting probability of protein-protein interaction partners. In Hoheisel, J.D. (Ed.). PLoS One, 7(1), e30938.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0030938.
Lu, S., Huang, W., Li, X., Huang, Z., Liu, X., Chen, Y., Shi, T., & Zhang, J. (2012). Insights into the role of magnesium triad in myo-inositol monophosphatase: metal mechanism, substrate binding, and lithium therapy. J Chem Inf Model, 52(9), 2398-2409.American Chemical Society (ACS). doi: 10.1021/ci300172r.
Tang, J., Huang, Z.M., Chen, Y.Y., Zhang, Z.H., Liu, G.L., & Zhang, J. (2012). A novel inhibitor of human La protein with anti-HBV activity discovered by structure-based virtual screening and in vitro evaluation. In Blackard, J. (Ed.). PLoS One, 7(4), e36363.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0036363.
Wang, Q., Zheng, M., Huang, Z., Liu, X., Zhou, H., Chen, Y., Shi, T., & Zhang, J. (2012). Toward understanding the molecular basis for chemical allosteric modulator design. J Mol Graph Model, 38, 324-333.Elsevier. doi: 10.1016/j.jmgm.2012.07.006.
Huang, Z., Zhu, L., Cao, Y., Wu, G., Liu, X., Chen, Y., Wang, Q., Shi, T., Zhao, Y., Wang, Y., Li, W., Li, Y., Chen, H., Chen, G., & Zhang, J. (2011). ASD: a comprehensive database of allosteric proteins and modulators. Nucleic Acids Res, 39(Database issue), D663-D669.Oxford University Press (OUP). doi: 10.1093/nar/gkq1022.
Liu, X., Su, X., Wang, F., Huang, Z., Wang, Q., Li, Z., Zhang, R., Wu, L., Pan, Y., Chen, Y., Zhuang, H., Chen, G., Shi, T., & Zhang, J. (2011). ODORactor: a web server for deciphering olfactory coding. Bioinformatics, 27(16), 2302-2303.Oxford University Press (OUP). doi: 10.1093/bioinformatics/btr385.
Zhao, Y., Lu, X., Yang, C.Y., Huang, Z., Fu, W., Hou, T., & Zhang, J. (2010). Computational modeling toward understanding agonist binding on dopamine 3. J Chem Inf Model, 50(9), 1633-1643.American Chemical Society (ACS). doi: 10.1021/ci1002119.
Wu, K., Wu, Y., Vadgama, J., Chen, Q.H., Huang, Z.M., & Li, Q. (2024). The Wip1 phosphatase activator QGC-8-52 selectively sensitizes p53-deficient cancer cells to chemotherapy. In CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 33(9).American Association for Cancer Research (AACR). doi: 10.1158/1538-7755.DISP24-C030.