Yijen Wu

Cortes, D.R.E., Stapleton, M.C., Schwab, K.E., West, D., Coulson, N.W., O'Donnell, M.G., Christodoulou, A.G., Powers, R.W., & Wu, Y.L. (2024). Modeling normal mouse uterine contraction and placental perfusion with non-invasive longitudinal dynamic contrast enhancement MRI. In Engelhardt, B.W. (Ed.). PLoS One, 19(7), e0303957.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0303957.

Cortes, D.R.E., Stapleton, M.C., Schwab, K.E., West, D., Coulson, N.W., O'Donnell, M.G., Powers, R.W., & Wu, Y.L. (2024). Modeling Normal Mouse Uterine Contraction and Placental Perfusion with Non-invasive Longitudinal Dynamic Contrast Enhancement MRI. bioRxiv, 5(02-13), 2024.01.31.577398.Cold Spring Harbor Laboratory. doi: 10.1101/2024.01.31.577398.

Reynolds, W.T., Votava-Smith, J.K., Gabriel, G., Lee, V.K., Rajagopalan, V., Wu, Y., Liu, X., Yagi, H., Slabicki, R., Gibbs, B., Tran, N.N., Weisert, M., Cabral, L., Subramanian, S., Wallace, J., Del Castillo, S., Baust, T., Weinberg, J.G., Lorenzi Quigley, L., Gaesser, J., O'Neil, S.H., Schmithorst, V., Panigrahy, A., Ceschin, R., & Lo, C.W. (2024). Validation of a Paralimbic-Related Subcortical Brain Dysmaturation MRI Score in Infants with Congenital Heart Disease. J Clin Med, 13(19), 5772.MDPI. doi: 10.3390/jcm13195772.

Wu, Y.L., Christodoulou, A.G., Beumer, J.H., Rigatti, L.H., Fisher, R., Ross, M., Watkins, S., Cortes, D.R.E., Ruck, C., Manzoor, S., Wyman, S.K., Stapleton, M.C., Goetzman, E., Bharathi, S., Wipf, P., Tan, T., Eiseman, J.L., Christner, S.M., Guo, J., Lo, C.W.Y., Epperly, M.W., & Greenberger, J.S. (2024). Mitigation of Fetal Irradiation Injury from Mid-Gestation Total Body Radiation with Mitochondrial-Targeted GS-Nitroxide JP4-039. bioRxiv, 5(02-23), 2024.02.13.580105.Cold Spring Harbor Laboratory. doi: 10.1101/2024.02.13.580105.

Shang, P., Simpson, J.D., Taylor, G.M., Sutherland, D.M., Welsh, O.L., Aravamudhan, P., Natividade, R.D.S., Schwab, K., Michel, J.J., Poholek, A.C., Wu, Y., Rajasundaram, D., Koehler, M., Alsteens, D., & Dermody, T.S. (2023). Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus. Nat Commun, 14(1), 2615.Springer Nature. doi: 10.1038/s41467-023-38327-6.

Turan, S., Chaillet, J.R., Stapleton, M.C., & Wu, Y.L. (2023). Genome Editing and Myocardial Development. Adv Exp Med Biol, 1396, 53-73.Springer Nature. doi: 10.1007/978-981-19-5642-3_4.

Carew, N.T., Schmidt, H.M., Yuan, S., Galley, J.C., Hall, R., Altmann, H.M., Hahn, S.A., Miller, M.P., Wood, K.C., Gabris, B., Stapleton, M.C., Hartwick, S., Fazzari, M., Wu, Y.L., Trebak, M., Kaufman, B.A., McTiernan, C.F., Schopfer, F.J., Navas, P., Thibodeau, P.H., McNamara, D.M., Salama, G., & Straub, A.C. (2022). Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death. J Clin Invest, 132(18), e147120.American Society for Clinical Investigation. doi: 10.1172/JCI147120.

Han, L., Mich-Basso, J.D., Li, Y., Ammanamanchi, N., Xu, J., Bargaje, A.P., Liu, H., Wu, L., Jeong, J.H., Franks, J., Stolz, D.B., Wu, Y.L., Rajasundaram, D., Liu, Y., & Kühn, B. (2022). Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts. Dev Cell, 57(20), 2397-2411.e9.Elsevier. doi: 10.1016/j.devcel.2022.09.017.

Chen, A., Jiang, Y., Li, Z., Wu, L., Santiago, U., Zou, H., Cai, C., Sharma, V., Guan, Y., McCarl, L.H., Ma, J., Wu, Y.L., Michel, J., Shi, Y., Konnikova, L., Amankulor, N.M., Zinn, P.O., Kohanbash, G., Agnihotri, S., Lu, S., Lu, X., Sun, D., Gittes, G.K., Wang, Q., Xiao, X., Yimlamai, D., Pollack, I.F., Camacho, C.J., & Hu, B. (2021). Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma. J Clin Invest, 131(16), 147552.American Society for Clinical Investigation. doi: 10.1172/JCI147552.

Chiba, T., Cerqueira, D.M., Li, Y., Bodnar, A.J., Mukherjee, E., Pfister, K., Phua, Y.L., Shaikh, K., Sanders, B.T., Hemker, S.L., Pagano, P.J., Wu, Y.L., Ho, J., & Sims-Lucas, S. (2021). Endothelial-Derived miR-17∼92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol, 32(3), 553-562.Wolters Kluwer. doi: 10.1681/ASN.2020050717.

Feldman, K.S., Kim, E., Czachowski, M.J., Wu, Y., Lo, C.W., & Zahid, M. (2021). Differential effect of anesthetics on mucociliary clearance in vivo in mice. Sci Rep, 11(1), 4896.Springer Nature. doi: 10.1038/s41598-021-84605-y.

Gabriel, G.C., Devine, W., Redel, B.K., Whitworth, K.M., Samuel, M., Spate, L.D., Cecil, R.F., Prather, R.S., Wu, Y., Wells, K.D., & Lo, C.W. (2021). Cardiovascular Development and Congenital Heart Disease Modeling in the Pig. J Am Heart Assoc, 10(14), e021631.Wolters Kluwer. doi: 10.1161/JAHA.121.021631.

Satoh, T., Wang, L., Espinosa-Diez, C., Wang, B., Hahn, S.A., Noda, K., Rochon, E.R., Dent, M.R., Levine, A.R., Baust, J.J., Wyman, S., Wu, Y.L., Triantafyllou, G.A., Tang, Y., Reynolds, M., Shiva, S., Hilaire, C.S., Gomez, D., Goncharov, D.A., Goncharova, E.A., Chan, S.Y., Straub, A.C., Lai, Y.C., McTiernan, C.F., & Gladwin, M.T. (2021). Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction. Circulation, 144(8), 615-637.Wolters Kluwer. doi: 10.1161/CIRCULATIONAHA.121.053889.

Sinsheimer, A., Mohsen, A.W., Bloom, K., Karunanidhi, A., Bharathi, S., Wu, Y.L., Schiff, M., Wang, Y., Goetzman, E.S., Ghaloul-Gonzalez, L., & Vockley, J. (2021). Development and characterization of a mouse model for Acad9 deficiency. Mol Genet Metab, 134(1-2), 156-163.Elsevier. doi: 10.1016/j.ymgme.2021.09.002.

Teekakirikul, P., Zhu, W., Gabriel, G.C., Young, C.B., Williams, K., Martin, L.J., Hill, J.C., Richards, T., Billaud, M., Phillippi, J.A., Wang, J., Wu, Y., Tan, T., Devine, W., Lin, J.H., Bais, A.S., Klonowski, J., Moreau de Bellaing, A., Saini, A., Wang, M.X., Emerel, L., Salamacha, N., Wyman, S.K., Lee, C., Sing Li, H., Miron, A., Zhang, J., Xing, J., McNamara, D.M., Fung, E., Kirshbom, P., Mahle, W., Kochilas, L.K., He, Y., Garg, V., White, P., McBride, K.L., Benson, D.W., Gleason, T.G., Mital, S., & Lo, C.W. (2021). Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv, 2(3), 100037.Elsevier. doi: 10.1016/j.xhgg.2021.100037.

Wu, Y.L. (2021). Cardiac MRI Assessment of Mouse Myocardial Infarction and Regeneration. Methods Mol Biol, 2158, 81-106.Springer Nature. doi: 10.1007/978-1-0716-0668-1_8.

Airik, M., Schüler, M., McCourt, B., Weiss, A.C., Herdman, N., Lüdtke, T.H., Widmeier, E., Stolz, D.B., Nejak-Bowen, K.N., Yimlamai, D., Wu, Y.L., Kispert, A., Airik, R., & Hildebrandt, F. (2020). Loss of Anks6 leads to YAP deficiency and liver abnormalities. Hum Mol Genet, 29(18), 3064-3080.Oxford University Press (OUP). doi: 10.1093/hmg/ddaa197.

Han, L., Choudhury, S., Mich-Basso, J.D., Ammanamanchi, N., Ganapathy, B., Suresh, S., Khaladkar, M., Singh, J., Maehr, R., Zuppo, D.A., Kim, J., Eberwine, J.H., Wyman, S.K., Wu, Y.L., & Kühn, B. (2020). Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration. Dev Cell, 53(1), 42-59.e11.Elsevier. doi: 10.1016/j.devcel.2020.01.030.

Henkel, M., Partyka, J., Gregory, A.D., Forno, E., Cho, M.H., Eddens, T., Tout, A.R., Salamacha, N., Horne, W., Rao, K.S., Wu, Y., Alcorn, J.F., Kostka, D., Hirsch, R., Celedón, J.C., Shapiro, S.D., Kolls, J.K., & Campfield, B.T. (2020). FSTL-1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema. Am J Respir Crit Care Med, 201(8), 934-945.American Thoracic Society. doi: 10.1164/rccm.201905-0973OC.

Kapralov, A.A., Yang, Q., Dar, H.H., Tyurina, Y.Y., Anthonymuthu, T.S., Kim, R., St Croix, C.M., Mikulska-Ruminska, K., Liu, B., Shrivastava, I.H., Tyurin, V.A., Ting, H.C., Wu, Y.L., Gao, Y., Shurin, G.V., Artyukhova, M.A., Ponomareva, L.A., Timashev, P.S., Domingues, R.M., Stoyanovsky, D.A., Greenberger, J.S., Mallampalli, R.K., Bahar, I., Gabrilovich, D.I., Bayır, H., & Kagan, V.E. (2020). Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol, 16(3), 278-290.Springer Nature. doi: 10.1038/s41589-019-0462-8.

Koppes, E.A., Redel, B.K., Johnson, M.A., Skvorak, K.J., Ghaloul-Gonzalez, L., Yates, M.E., Lewis, D.W., Gollin, S.M., Wu, Y.L., Christ, S.E., Yerle, M., Leshinski, A., Spate, L.D., Benne, J.A., Murphy, S.L., Samuel, M.S., Walters, E.M., Hansen, S.A., Wells, K.D., Lichter-Konecki, U., Wagner, R.A., Newsome, J.T., Dobrowolski, S.F., Vockley, J., Prather, R.S., & Nicholls, R.D. (2020). A porcine model of phenylketonuria generated by CRISPR/Cas9 genome editing. JCI Insight, 5(20), e141523.American Society for Clinical Investigation. doi: 10.1172/jci.insight.141523.

Ling, X., Latoche, J.D., Choy, C.J., Kurland, B.F., Laymon, C.M., Wu, Y., Salamacha, N., Shen, D., Geruntho, J.J., Rigatti, L.H., Windish, H.P., Langton-Webster, B., Berkman, C.E., & Anderson, C.J. (2020). Preclinical Dosimetry, Imaging, and Targeted Radionuclide Therapy Studies of Lu-177-Labeled Albumin-Binding, PSMA-Targeted CTT1403. Mol Imaging Biol, 22(2), 274-284.Springer Nature. doi: 10.1007/s11307-019-01404-8.

Pang, D., Wu, Y.L., Alcamo, A.M., Cummings, J., Di Caro, V., Walko, T., Hsue, V., Clark, R.S.B., Panigrahy, A., Kochanek, P.M., & Aneja, R.K. (2020). Early Axonal Injury and Delayed Cytotoxic Cerebral Edema are Associated with Microglial Activation in a Mouse Model of Sepsis. Shock, 54(2), 256-264.Wolters Kluwer. doi: 10.1097/SHK.0000000000001446.

Rutledge, C., Cater, G., McMahon, B., Guo, L., Nouraie, S.M., Wu, Y., Villanueva, F., & Kaufman, B.A. (2020). Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction. Cardiovasc Ultrasound, 18(1), 9.Springer Nature. doi: 10.1186/s12947-020-00191-5.

Liu, H., Zhang, C.H., Ammanamanchi, N., Suresh, S., Lewarchik, C., Rao, K., Uys, G.M., Han, L., Abrial, M., Yimlamai, D., Ganapathy, B., Guillermier, C., Chen, N., Khaladkar, M., Spaethling, J., Eberwine, J.H., Kim, J., Walsh, S., Choudhury, S., Little, K., Francis, K., Sharma, M., Viegas, M., Bais, A., Kostka, D., Ding, J., Bar-Joseph, Z., Wu, Y., Yechoor, V., Moulik, M., Johnson, J., Weinberg, J., Reyes-Múgica, M., Steinhauser, M.L., & Kühn, B. (2019). Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci Transl Med, 11(513), eaaw6419.American Association for the Advancement of Science (AAAS). doi: 10.1126/scitranslmed.aaw6419.

Yagi, H., Liu, X., Gabriel, G.C., Wu, Y., Peterson, K., Murray, S.A., Aronow, B.J., Martin, L.J., Benson, D.W., & Lo, C.W. (2018). The Genetic Landscape of Hypoplastic Left Heart Syndrome. Pediatr Cardiol, 39(6), 1069-1081.Springer Nature. doi: 10.1007/s00246-018-1861-4.

Zahid, M., Feldman, K.S., Garcia-Borrero, G., Feinstein, T.N., Pogodzinski, N., Xu, X., Yurko, R., Czachowski, M., Wu, Y.L., Mason, N.S., & Lo, C.W. (2018). Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Bio-Distribution, Imaging Application, and Mechanism of Transduction. Biomolecules, 8(4), 147.MDPI. doi: 10.3390/biom8040147.

Liu, X., Kim, A.J., Reynolds, W., Wu, Y., & Lo, C.W. (2017). Phenotyping cardiac and structural birth defects in fetal and newborn mice. Birth Defects Res, 109(10), 778-790.Wiley. doi: 10.1002/bdr2.1048.

Liu, X., Yagi, H., Saeed, S., Bais, A.S., Gabriel, G.C., Chen, Z., Peterson, K.A., Li, Y., Schwartz, M.C., Reynolds, W.T., Saydmohammed, M., Gibbs, B., Wu, Y., Devine, W., Chatterjee, B., Klena, N.T., Kostka, D., de Mesy Bentley, K.L., Ganapathiraju, M.K., Dexheimer, P., Leatherbury, L., Khalifa, O., Bhagat, A., Zahid, M., Pu, W., Watkins, S., Grossfeld, P., Murray, S.A., Porter, G.A., Tsang, M., Martin, L.J., Benson, D.W., Aronow, B.J., & Lo, C.W. (2017). The complex genetics of hypoplastic left heart syndrome. Nat Genet, 49(7), 1152-1159.Springer Nature. doi: 10.1038/ng.3870.

Wu, Y.L., & Lo, C.W. (2017). Diverse application of MRI for mouse phenotyping. Birth Defects Res, 109(10), 758-770.Wiley. doi: 10.1002/bdr2.1051.

Ye, Q., Liu, L., Wu, Y.L., Yeh, F., Li, W.F., Tseng, L., & Ho, C. (2017). Intralipid® attenuates acute cardiac allograft rejection in relation to promoting CD4+CD25+Foxp3+ regulatory T-cells and inhibiting toll-like receptor 4 expression. Transplantation Reports, 2(1), 1-9.Elsevier. doi: 10.1016/j.tpr.2017.05.001.

Yeh, F.C., Liu, L., Hitchens, T.K., & Wu, Y.L. (2017). Mapping immune cell infiltration using restricted diffusion MRI. Magn Reson Med, 77(2), 603-612.Wiley. doi: 10.1002/mrm.26143.

Ganapathy, B., Nandhagopal, N., Polizzotti, B.D., Bennett, D., Asan, A., Wu, Y., & Kühn, B. (2016). Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth. In Calvert, J. (Ed.). PLoS One, 11(5), e0155456.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0155456.

Liu, L., Tseng, L., Ye, Q., Wu, Y.L., Bain, D.J., & Ho, C. (2016). A New Method for Preparing Mesenchymal Stem Cells and Labeling with Ferumoxytol for Cell Tracking by MRI. Sci Rep, 6(1), 26271.Springer Nature. doi: 10.1038/srep26271.

Pearce, P.S., Wu, Y., Rapuano, A., Kelly, K.M., de Lanerolle, N., & Pan, J.W. (2016). Metabolic injury in a variable rat model of post-status epilepticus. Epilepsia, 57(12), 1978-1986.Wiley. doi: 10.1111/epi.13588.

Wu, Y., Pearce, P.S., Rapuano, A., Hitchens, T.K., de Lanerolle, N.C., & Pan, J.W. (2015). Metabolic changes in early poststatus epilepticus measured by MR spectroscopy in rats. J Cereb Blood Flow Metab, 35(11), 1862-1870.SAGE Publications. doi: 10.1038/jcbfm.2015.145.

Christodoulou, A.G., Hitchens, T.K., Wu, Y.L., Ho, C., & Liang, Z.P. (2014). Improved subspace estimation for low-rank model-based accelerated cardiac imaging. IEEE Trans Biomed Eng, 61(9), 2451-2457.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TBME.2014.2320463.

Liu, L., Hitchens, T.K., Ye, Q., Wu, Y., Barbe, B., Prior, D.E., Li, W.F., Yeh, F.C., Foley, L.M., Bain, D.J., & Ho, C. (2013). Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with Intralipid. Biochim Biophys Acta, 1830(6), 3447-3453.Elsevier. doi: 10.1016/j.bbagen.2013.01.021.

Wu, Y.L., Ye, Q., Eytan, D.F., Liu, L., Rosario, B.L., Hitchens, T.K., Yeh, F.C., Rooijen van, N., & Ho, C. (2013). Magnetic resonance imaging investigation of macrophages in acute cardiac allograft rejection after heart transplantation. Circ Cardiovasc Imaging, 6(6), 965-973.Wolters Kluwer. doi: 10.1161/CIRCIMAGING.113.000674.

Liu, L., Ye, Q., Wu, Y., Hsieh, W.Y., Chen, C.L., Shen, H.H., Wang, S.J., Zhang, H., Hitchens, T.K., & Ho, C. (2012). Tracking T-cells in vivo with a new nano-sized MRI contrast agent. Nanomedicine, 8(8), 1345-1354.Elsevier. doi: 10.1016/j.nano.2012.02.017.

Chen, C.L., Zhang, H., Ye, Q., Hsieh, W.Y., Hitchens, T.K., Shen, H.H., Liu, L., Wu, Y.J., Foley, L.M., Wang, S.J., & Ho, C. (2011). A new nano-sized iron oxide particle with high sensitivity for cellular magnetic resonance imaging. Mol Imaging Biol, 13(5), 825-839.Springer Nature. doi: 10.1007/s11307-010-0430-x.

Wu, Y.L., Ye, Q., & Ho, C. (2011). Cellular and Functional Imaging of Cardiac Transplant Rejection. Curr Cardiovasc Imaging Rep, 4(1), 50-62.Springer Nature. doi: 10.1007/s12410-010-9055-3.

Wu, Y.L., Ye, Q., Sato, K., Foley, L.M., Hitchens, T.K., & Ho, C. (2009). Noninvasive evaluation of cardiac allograft rejection by cellular and functional cardiac magnetic resonance. JACC Cardiovasc Imaging, 2(6), 731-741.Elsevier. doi: 10.1016/j.jcmg.2009.01.013.

Mills, P.H., Wu, Y.J.L., Ho, C., & Ahrens, E.T. (2008). Sensitive and automated detection of iron-oxide-labeled cells using phase image cross-correlation analysis. Magn Reson Imaging, 26(5), 618-628.Elsevier. doi: 10.1016/j.mri.2008.01.007.

Ye, Q., Wu, Y.L., Foley, L.M., Hitchens, T.K., Eytan, D.F., Shirwan, H., & Ho, C. (2008). Longitudinal tracking of recipient macrophages in a rat chronic cardiac allograft rejection model with noninvasive magnetic resonance imaging using micrometer-sized paramagnetic iron oxide particles. Circulation, 118(2), 149-156.Wolters Kluwer. doi: 10.1161/CIRCULATIONAHA.107.746354.

Chang, H.H., Moura, J.M.F., Wu, Y.L., & Ho, C. (2006). Immune cells detection of the in vivo rejecting heart in USPIO-enhanced magnetic resonance imaging. Conf Proc IEEE Eng Med Biol Soc, 2006, 942-945.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/iembs.2006.259443.

Wu, Y.L., Ye, Q., Foley, L.M., Hitchens, T.K., Sato, K., Williams, J.B., & Ho, C. (2006). In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI. Proc Natl Acad Sci U S A, 103(6), 1852-1857.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0507198103.

Aoki, I., Wu, Y.J.L., Silva, A.C., Lynch, R.M., & Koretsky, A.P. (2004). In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI. Neuroimage, 22(3), 1046-1059.Elsevier. doi: 10.1016/j.neuroimage.2004.03.031.

Wu, Y.J.L., Sato, K., Ye, Q., & Ho, C. (2004). MRI investigations of graft rejection following organ transplantation using rodent models. Methods Enzymol, 386, 73-105.Elsevier. doi: 10.1016/S0076-6879(04)86003-8.

Kanno, S., Wu, Y.J., Lee, P.C., Billiar, T.R., & Ho, C. (2001). Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats. Circulation, 104(8), 945-950.Wolters Kluwer. doi: 10.1161/hc3401.093155.

Kanno, S., Wu, Y.J., Lee, P.C., Dodd, S.J., Williams, M., Griffith, B.P., & Ho, C. (2001). Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles. Circulation, 104(8), 934-938.Wolters Kluwer. doi: 10.1161/hc3401.093148.