headshot of Xing Chen

Xing Chen

Assistant Professor
x.chen@pitt.edu
Website Bioengineering Department

overview

The Chen lab develops high-channel-count, chronically implantable devices to record from and stimulate the brain. We harness cutting-edge developments in electrode fabrication and microelectronics to improve probe durability and biocompatibility, generating fundamental neuroscientific knowledge and translating results from the lab to the clinic.

about

(2021) Netherlands Institute for Neuroscience Brain Award for Scientific Excellence.

(2019) SfN ‘Hot Topic’ Poster.

(2018) Amsterdam Neuroscience Meeting Best Poster Award.

PhD, Newcastle University

BA, University of Southern California

Wang, F., Chen, X., & Roelfsema, P.R. (2024). Comparison of electrical microstimulation artifact removal methods for high-channel-count prostheses. J Neurosci Methods, 408, 110169.Elsevier. doi: 10.1016/j.jneumeth.2024.110169.

Chen, X., Wang, F., Kooijmans, R., Klink, P.C., Boehler, C., Asplund, M., & Roelfsema, P.R. (2023). Chronic stability of a neuroprosthesis comprising multiple adjacent Utah arrays in monkeys. J Neural Eng, 20(3), 036039.IOP Publishing. doi: 10.1088/1741-2552/ace07e.

Chen, X., Morales-Gregorio, A., Sprenger, J., Kleinjohann, A., Sridhar, S., van Albada, S.J., Grün, S., & Roelfsema, P.R. (2022). 1024-channel electrophysiological recordings in macaque V1 and V4 during resting state. Sci Data, 9(1), 77.Springer Nature. doi: 10.1038/s41597-022-01180-1.

van Velthoven, E.A.M., van Stuijvenberg, O.C., Haselager, D.R.E., Broekman, M., Chen, X., Roelfsema, P., Bredenoord, A.L., & Jongsma, K.R. (2022). Ethical implications of visual neuroprostheses-a systematic review. J Neural Eng, 19(2), 026055.IOP Publishing. doi: 10.1088/1741-2552/ac65b2.

Fernández, E., Alfaro, A., Soto-Sánchez, C., Gonzalez-Lopez, P., Lozano, A.M., Peña, S., Grima, M.D., Rodil, A., Gómez, B., Chen, X., Roelfsema, P.R., Rolston, J.D., Davis, T.S., & Normann, R.A. (2021). Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex. J Clin Invest, 131(23), e151331.American Society for Clinical Investigation. doi: 10.1172/JCI151331.

Klink, P.C., Chen, X., Vanduffel, W., & Roelfsema, P.R. (2021). Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex. Elife, 10, e67304.eLife. doi: 10.7554/eLife.67304.

Chen, X., Wang, F., Fernandez, E., & Roelfsema, P.R. (2020). Shape perception via a high-channel-count neuroprosthesis in monkey visual cortex. Science, 370(6521), 1191-1196.American Association for the Advancement of Science (AAAS). doi: 10.1126/science.abd7435.

Gilson, M., Tauste Campo, A., Chen, X., Thiele, A., & Deco, G. (2018). Nonparametric test for connectivity detection in multivariate autoregressive networks and application to multiunit activity data. Netw Neurosci, 1(4), 357-380.MIT Press. doi: 10.1162/NETN_a_00019.

Sanayei, M., Chen, X., Chicharro, D., Distler, C., Panzeri, S., & Thiele, A. (2018). Perceptual learning of fine contrast discrimination changes neuronal tuning and population coding in macaque V4. Nat Commun, 9(1), 4238.Springer Nature. doi: 10.1038/s41467-018-06698-w.

Chen, X., Possel, J.K., Wacongne, C., van Ham, A.F., Klink, P.C., & Roelfsema, P.R. (2017). 3D printing and modelling of customized implants and surgical guides for non-human primates. J Neurosci Methods, 286, 38-55.Elsevier. doi: 10.1016/j.jneumeth.2017.05.013.

Tomsett, R.J., Ainsworth, M., Thiele, A., Sanayei, M., Chen, X., Gieselmann, M.A., Whittington, M.A., Cunningham, M.O., & Kaiser, M. (2015). Virtual Electrode Recording Tool for EXtracellular potentials (VERTEX): comparing multi-electrode recordings from simulated and biological mammalian cortical tissue. Brain Struct Funct, 220(4), 2333-2353.Springer Nature. doi: 10.1007/s00429-014-0793-x.

Chen, X., Sanayei, M., & Thiele, A. (2014). Stimulus roving and flankers affect perceptual learning of contrast discrimination in Macaca mulatta. In Chelazzi, L. (Ed.). PLoS One, 9(10), e109604.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0109604.

Chen, X., Sanayei, M., & Thiele, A. (2013). Perceptual learning of contrast discrimination in macaca mulatta. J Vis, 13(13), 22.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/13.13.22.

Chen, X., Hoffmann, K.P., Albright, T.D., & Thiele, A. (2012). Effect of feature-selective attention on neuronal responses in macaque area MT. J Neurophysiol, 107(5), 1530-1543.American Physiological Society. doi: 10.1152/jn.01042.2010.

Bartolo, M.J., Gieselmann, M.A., Vuksanovic, V., Hunter, D., Sun, L., Chen, X., Delicato, L.S., & Thiele, A. (2011). Stimulus-induced dissociation of neuronal firing rates and local field potential gamma power and its relationship to the resonance blood oxygen level-dependent signal in macaque primary visual cortex. Eur J Neurosci, 34(11), 1857-1870.Wiley. doi: 10.1111/j.1460-9568.2011.07877.x.