Postdoctoral in Bioengineering, University of Pittsburgh, 2011 - 2013
PhD, Biomedical Engineering, University of Michigan, 2005 - 2011
MS, Biomedical Engineering, University of Michigan, 2005 - 2007
BA, Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 2001 - 2005
BA, Biochemistry, University of Colorado, Boulder, 2001 - 2005
Forrest, A.M., Kunigk, N.G., Collinger, J.L., Gaunt, R.A., Chen, X., Geest, J.P.V., & Kozai, T.D.Y. (2025). Finite element model predicts micromotion-induced strain profiles that correlate with the functional performance of Utah arrays in humans and non-human primates. In bioRxiv. doi: 10.1101/2025.04.10.648248.
Hughes, C.L., Stieger, K.C., Chen, K., Vazquez, A.L., & Kozai, T.D. (2025). Spatiotemporal properties of cortical excitatory and inhibitory neuron activation by sustained and bursting electrical microstimulation. iScience, 28(6), 112707.Elsevier. doi: 10.1016/j.isci.2025.112707.
Wellman, S.M., Forrest, A.M., Douglas, M.M., Subbaraman, A., Zhang, G., & Kozai, T.D.Y. (2025). Dynamic changes in the structure and function of brain mural cells around chronically implanted microelectrodes. Biomaterials, 315, 122963.Elsevier. doi: 10.1016/j.biomaterials.2024.122963.
Chen, K., Forrest, A.M., Burgos, G.G., & Kozai, T.D.Y. (2024). Neuronal functional connectivity is impaired in a layer dependent manner near chronically implanted intracortical microelectrodes in C57BL6 wildtype mice. J Neural Eng, 21(3), 10.1088/1741-12552/ad5049.IOP Publishing. doi: 10.1088/1741-2552/ad5049.
Chen, K., Wu, B., Krahe, D., Vazquez, A., Siegenthaler, J.R., Rechenberg, R., Li, W., Cui, X.T., & Kozai, T.D.Y. (2024). Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neuromodulation Technology Development. 2024.02.17.580823.Cold Spring Harbor Laboratory. doi: 10.1101/2024.02.17.580823.
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Hughes, C.L., Stieger, K.A., Chen, K., Vazquez, A.L., & Kozai, T.D. (2024). Spatiotemporal properties of cortical excitatory and inhibitory neuron activation by sustained and bursting electrical microstimulation. In bioRxiv. doi: 10.1101/2024.09.30.615029.
Li, F., Gallego, J., Tirko, N.N., Greaser, J., Bashe, D., Patel, R., Shaker, E., Van Valkenburg, G.E., Alsubhi, A.S., Wellman, S., Singh, V., Padilla, C.G., Gheres, K.W., Broussard, J.I., Bagwell, R., Mulvihill, M., & Kozai, T.D.Y. (2024). Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation. Nat Commun, 15(1), 5512.Springer Nature. doi: 10.1038/s41467-024-49709-9.
Li, F., Gallego, J., Tirko, N.N., Greaser, J., Bashe, D., Patel, R., Shaker, E., Van Valkenburg, G.E., Alsubhi, A.S., Wellman, S., Singh, V., Padilla, C.G., Gheres, K.W., Broussard, J.I., Bagwell, R., Mulvihill, M., & Kozai, T.D.Y. (2024). Author Correction: Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation. Nat Commun, 15(1), 7618.Springer Nature. doi: 10.1038/s41467-024-52088-w.
McNamara, I.N., Wellman, S.M., Li, L., Eles, J.R., Savya, S., Sohal, H.S., Angle, M.R., & Kozai, T.D.Y. (2024). Electrode sharpness and insertion speed reduce tissue damage near high-density penetrating arrays. J Neural Eng, 21(2), 026030.IOP Publishing. doi: 10.1088/1741-2552/ad36e1.
Robbins, C., Eles, J., Zheng, X.S., Kozai, T., Cui, X.T., & Vazquez, A. (2024). Longitudinal changes in electrophysiology and widefield calcium imaging following electrode implantation. J Neural Eng, 21(6), 066043.IOP Publishing. doi: 10.1088/1741-2552/ada0eb.
Suematsu, N., Vazquez, A.L., & Kozai, T.D. (2024). Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex. bioRxiv, 5(01-22), 2024.01.01.573814.Cold Spring Harbor Laboratory. doi: 10.1101/2024.01.01.573814.
Suematsu, N., Vazquez, A.L., & Kozai, T.D.Y. (2024). Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex. J Neural Eng, 21(2), 026033.IOP Publishing. doi: 10.1088/1741-2552/ad3853.
Wellman, S., Forrest, A.M., Douglas, M.M., Subbaraman, A., Zhang, G., & Kozai, T.D.Y. (2024). Dynamic changes in structure and function of brain mural cells around chronically implanted microelectrodes. bioRxiv, 2024.06.11.598494.Cold Spring Harbor Laboratory. doi: 10.1101/2024.06.11.598494.
Chen, K., Cambi, F., & Kozai, T.D.Y. (2023). Pro-myelinating Clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health. bioRxiv, 4(02-10), 2023.01.31.526463.Cold Spring Harbor Laboratory. doi: 10.1101/2023.01.31.526463.
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Chen, K., Stieger, K.C., & Kozai, T.D. (2021). Challenges and opportunities of advanced gliomodulation technologies for excitation-inhibition balance of brain networks. Curr Opin Biotechnol, 72, 112-120.Elsevier. doi: 10.1016/j.copbio.2021.10.008.
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Stocking, K.C., Vazquez, A.L., & Kozai, T.D.Y. (2019). Intracortical Neural Stimulation With Untethered, Ultrasmall Carbon Fiber Electrodes Mediated by the Photoelectric Effect. IEEE Trans Biomed Eng, 66(8), 2402-2412.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TBME.2018.2889832.
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