headshot of Takashi Kozai

Takashi Kozai

Associate Professor
tdk18@pitt.edu
(412) 383-9044
Linkedin Bioengineering Department

overview

Takashi Kozai is an Associate Professor of Bioengineering at the University of Pittsburgh. He received the B.A. (magna cum laude) degree with distinction in Molecular, Cellular, and Developmental Biology, and another B.A. degree with distinction in Biochemistry from the University of Colorado, Boulder, CO, USA, both in 2005, and M.S. and Ph.D. degrees in Biomedical Engineering from the University of Michigan, Ann Arbor, MI, USA, in 2007 and 2011, respectively. From 2011 to 2013, he was a Postdoc with the Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA, where he was appointed as a Research Assistant Professor from 2013-2015 before starting his own lab. His research interests include: (1) Manipulation of neuronal and non-neuronal cells to influence the function of neuronal networks, (2) Understanding the role of neuroimmune cells in neuronal damage and regeneration, and (3) Improving long-term performance of implanted electrodes and integrating man-made (engineered) technology with the human brain for the purpose of studying normal and injured/diseased nervous systems in vivo at the cellular level, as well as restoring function to patients.

about

Postdoctoral in Bioengineering, University of Pittsburgh, 2011 - 2013

PhD, Biomedical Engineering, University of Michigan, 2005 - 2011

MS, Biomedical Engineering, University of Michigan, 2005 - 2007

BA, Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 2001 - 2005

BA, Biochemistry, University of Colorado, Boulder, 2001 - 2005

Chen, K., Forrest, A.M., Burgos, G.G., & Kozai, T.D.Y. (2024). Neuronal functional connectivity is impaired in a layer dependent manner near chronically implanted intracortical microelectrodes in C57BL6 wildtype mice. JOURNAL OF NEURAL ENGINEERING, 21(3), 036033.IOP Publishing. doi: 10.1088/1741-2552/ad5049.

Chen, K., Wu, B., Krahe, D., Vazquez, A., Siegenthaler, J.R., Rechenberg, R., Li, W., Cui, X.T., & Kozai, T.D.Y. (2024). Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neuromodulation Technology Development. 2024.02.17.580823.Cold Spring Harbor Laboratory. doi: 10.1101/2024.02.17.580823.

Chen, K., Wu, B., Krahe, D., Vazquez, A., Siegenthaler, J.R., Rechenberg, R., Li, W., Cui, X.T., & Kozai, T.D.Y. (2024). Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neurostimulation Technology Development. ADVANCED FUNCTIONAL MATERIALS, 34(41).Wiley. doi: 10.1002/adfm.202403164.

Hughes, C.L., Stieger, K.A., Chen, K., Vazquez, A.L., & Kozai, T.D. (2024). Spatiotemporal properties of cortical excitatory and inhibitory neuron activation by sustained and bursting electrical microstimulation. In bioRxiv. doi: 10.1101/2024.09.30.615029.

Li, F., Gallego, J., Tirko, N.N., Greaser, J., Bashe, D., Patel, R., Shaker, E., Van Valkenburg, G.E., Alsubhi, A.S., Wellman, S., Singh, V., Padilla, C.G., Gheres, K.W., Broussard, J.I., Bagwell, R., Mulvihill, M., & Kozai, T.D.Y. (2024). Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation. NATURE COMMUNICATIONS, 15(1), 5512.Springer Nature. doi: 10.1038/s41467-024-49709-9.

Li, F., Gallego, J., Tirko, N.N., Greaser, J., Bashe, D., Patel, R., Shaker, E., Van Valkenburg, G.E., Alsubhi, A.S., Wellman, S., Singh, V., Padilla, C.G., Gheres, K.W., Broussard, J.I., Bagwell, R., Mulvihill, M., & Kozai, T.D.Y. (2024). Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation (vol 15, pg 5512, 2024). NATURE COMMUNICATIONS, 15(1), 7618.Springer Nature. doi: 10.1038/s41467-024-52088-w.

McNamara, I.N., Wellman, S.M., Li, L., Eles, J.R., Savya, S., Sohal, H.S., Angle, M.R., & Kozai, T.D.Y. (2024). Electrode sharpness and insertion speed reduce tissue damage near high-density penetrating arrays. JOURNAL OF NEURAL ENGINEERING, 21(2), 026030.IOP Publishing. doi: 10.1088/1741-2552/ad36e1.

Suematsu, N., Vazquez, A.L., & Kozai, T.D. (2024). Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex. bioRxiv, 5(01-22), 2024.01.01.573814.Cold Spring Harbor Laboratory. doi: 10.1101/2024.01.01.573814.

Suematsu, N., Vazquez, A.L., & Kozai, T.D.Y. (2024). Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex. JOURNAL OF NEURAL ENGINEERING, 21(2), 026033.IOP Publishing. doi: 10.1088/1741-2552/ad3853.

Wellman, S.M., Forrest, A.M., Douglas, M.M., Subbaraman, A., Zhang, G., & Kozai, T.D.Y. (2024). Dynamic changes in structure and function of brain mural cells around chronically implanted microelectrodes. bioRxiv, 5(06-24), 2024.06.11.598494.Cold Spring Harbor Laboratory. doi: 10.1101/2024.06.11.598494.

Chen, K., Cambi, F., & Kozai, T.D.Y. (2023). Pro-myelinating Clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health. bioRxiv, 4(02-10), 2023.01.31.526463.Cold Spring Harbor Laboratory. doi: 10.1101/2023.01.31.526463.

Chen, K., Cambi, F., & Kozai, T.D.Y. (2023). Pro-myelinating clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health. BIOMATERIALS, 301, 122210.Elsevier. doi: 10.1016/j.biomaterials.2023.122210.

Chen, K., Forrest, A., Burgos, G.G., & Kozai, T.D.Y. (2023). Neuronal functional connectivity is impaired in a layer dependent manner near the chronically implanted microelectrodes. bioRxiv, 4(11-20), 2023.11.06.565852.Cold Spring Harbor Laboratory. doi: 10.1101/2023.11.06.565852.

Chen, K., Padilla, C.G., Kiselyov, K., & Kozai, T. (2023). Impairment of autophagy-lysosomal activity near the chronically implanted microelectrodes. 2023.05.31.543108.Cold Spring Harbor Laboratory. doi: 10.1101/2023.05.31.543108.

Chen, K., Padilla, C.G., Kiselyov, K., & Kozai, T.D.Y. (2023). Cell-specific alterations in autophagy-lysosomal activity near the chronically implanted microelectrodes. BIOMATERIALS, 302, 122316.Elsevier. doi: 10.1016/j.biomaterials.2023.122316.

Hughes, C., & Kozai, T. (2023). Dynamic amplitude modulation of microstimulation evokes biomimetic onset and offset transients and reduces depression of evoked calcium responses in sensory cortices. BRAIN STIMULATION, 16(3), 939-965.Elsevier. doi: 10.1016/j.brs.2023.05.013.

Li, F., Gallego, J., Tirko, N.N., Greaser, J., Bashe, D., Patel, R., Shaker, E., Van Valkenburg, G.E., Alsubhi, A.S., Wellman, S., Singh, V., Padill, C.G., Gheres, K.W., Bagwell, R., Mulvihill, M., & Kozai, T.D.Y. (2023). Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation. bioRxiv, 4(12-15), 2023.12.05.570162.Cold Spring Harbor Laboratory. doi: 10.1101/2023.12.05.570162.

McNamara, I.N., Wellman, S.M., Li, L., Eles, J.R., Savya, S., Sohal, H.S., Angle, M.R., & Kozai, T.D.Y. (2023). Electrode sharpness and insertion speed reduce tissue damage near high-density penetrating arrays. 2023.11.22.568119.Cold Spring Harbor Laboratory. doi: 10.1101/2023.11.22.568119.

Wellman, S.M., Coyne, O.A., Douglas, M.M., & Kozai, T.D.Y. (2023). Aberrant accumulation of age- and disease-associated factors following neural probe implantation in a mouse model of Alzheimer’s disease. bioRxiv, 4(02-16), 2023.02.11.528131.Cold Spring Harbor Laboratory. doi: 10.1101/2023.02.11.528131.

Wellman, S.M., Coyne, O.A., Douglas, M.M., & Kozai, T.D.Y. (2023). Aberrant accumulation of age- and disease-associated factors following neural probe implantation in a mouse model of Alzheimer’s disease. Journal of Neural Engineering, 20(4), 046044.IOP Publishing. doi: 10.1088/1741-2552/aceca5.

Hughes, C., & Kozai, T. (2022). Biomimetic microstimulation of sensory cortices. 2022.11.11.516221.Cold Spring Harbor Laboratory. doi: 10.1101/2022.11.11.516221.

Savya, S.P., Li, F., Lam, S., Wellman, S.M., Stieger, K.C., Chen, K., Eles, J.R., & Kozai, T.D.Y. (2022). In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation. 2022.07.01.498483.Cold Spring Harbor Laboratory. doi: 10.1101/2022.07.01.498483.

Savya, S.P., Li, F., Lam, S., Wellman, S.M., Stieger, K.C., Chen, K., Eles, J.R., & Kozai, T.D.Y. (2022). In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation. BIOMATERIALS, 289, 121784.Elsevier. doi: 10.1016/j.biomaterials.2022.121784.

Stieger, K.C., Eles, J.R., Ludwig, K.A., & Kozai, T.D.Y. (2022). Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation. 2022.01.14.476351.Cold Spring Harbor Laboratory. doi: 10.1101/2022.01.14.476351.

Stieger, K.C., Eles, J.R., Ludwig, K.A., & Kozai, T.D.Y. (2022). Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation. JOURNAL OF NEURAL ENGINEERING, 19(2), 026024.IOP Publishing. doi: 10.1088/1741-2552/ac5bf5.

Chen, K., Stieger, K.C., & Kozai, T.D. (2021). Challenges and opportunities of advanced gliomodulation technologies for excitation-inhibition balance of brain networks. CURRENT OPINION IN BIOTECHNOLOGY, 72, 112-120.Elsevier. doi: 10.1016/j.copbio.2021.10.008.

Chen, K., Wellman, S.M., Yaxiaer, Y., Eles, J.R., & Kozai, T.D.Y. (2021). In vivo spatiotemporal patterns of oligodendrocyte and myelin damage at the neural electrode interface. BIOMATERIALS, 268, 120526.Elsevier. doi: 10.1016/j.biomaterials.2020.120526.

Dubaniewicz, M., Eles, J.R., Lam, S., Song, S., Cambi, F., Sun, D., Wellman, S.M., & Kozai, T.D.Y. (2021). Inhibition of Na+/H+ exchanger modulates microglial activation and scar formation following microelectrode implantation. JOURNAL OF NEURAL ENGINEERING, 18(4), 045001.IOP Publishing. doi: 10.1088/1741-2552/abe8f1.

Eles, J.R., Stieger, K.C., & Kozai, T.D.Y. (2021). The temporal pattern of intracortical microstimulation pulses elicits distinct temporal and spatial recruitment of cortical neuropil and neurons. JOURNAL OF NEURAL ENGINEERING, 18(1), 015001.IOP Publishing. doi: 10.1088/1741-2552/abc29c.

Fitz, N.F., Nam, K.N., Wolfe, C.M., Letronne, F., Playso, B.E., Iordanova, B.E., Kozai, T.D.Y., Biedrzycki, R.J., Kagan, V.E., Tyurina, Y.Y., Han, X., Lefterov, I., & Koldamova, R. (2021). Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. NATURE COMMUNICATIONS, 12(1), 3416.Springer Nature. doi: 10.1038/s41467-021-23762-0.

Sahasrabuddhe, K., Khan, A.A., Singh, A.P., Stern, T.M., Ng, Y., Tadic, A., Orel, P., LaReau, C., Pouzzner, D., Nishimura, K., Boergens, K.M., Shivakumar, S., Hopper, M.S., Kerr, B., Hanna, M.E.S., Edgington, R.J., McNamara, I., Fell, D., Gao, P., Babaie-Fishani, A., Veijalainen, S., Klekachev, A.V., Stuckey, A.M., Luyssaert, B., Kozai, T.D.Y., Xie, C., Gilja, V., Dierickx, B., Kong, Y., Straka, M., Sohal, H.S., & Angle, M.R. (2021). The Argo: a high channel count recording system for neural recording in vivo. JOURNAL OF NEURAL ENGINEERING, 18(1), 015002.IOP Publishing. doi: 10.1088/1741-2552/abd0ce.

Trevathan, J.K., Asp, A.J., Nicolai, E.N., Trevathan, J.M., Kremer, N.A., Kozai, T.D.Y., Cheng, D., Schachter, M.J., Nassi, J.J., Otte, S.L., Parker, J.G., Lujan, J.L., & Ludwig, K.A. (2021). Calcium imaging in freely moving mice during electrical stimulation of deep brain structures. JOURNAL OF NEURAL ENGINEERING, 18(2), 10.1088/1741-12552/abb7a4.IOP Publishing. doi: 10.1088/1741-2552/abb7a4.

Bettinger, C.J., Ecker, M., Yoshida Kozai, T.D., Malliaras, G.G., Meng, E., & Voit, W. (2020). Recent advances in neural interfaces-Materials chemistry to clinical translation. MRS BULLETIN, 45(8), 655-668.Springer Nature. doi: 10.1557/mrs.2020.195.

Eles, J.R., & Kozai, T.D.Y. (2020). In vivo imaging of calcium and glutamate responses to intracortical microstimulation reveals distinct temporal responses of the neuropil and somatic compartments in layer II/III neurons. BIOMATERIALS, 234, 119767.Elsevier. doi: 10.1016/j.biomaterials.2020.119767.

Stieger, K.C., Eles, J.R., Ludwig, K.A., & Kozai, T.D.Y. (2020). In vivomicrostimulation with cathodic and anodic asymmetric waveforms modulates spatiotemporal calcium dynamics in cortical neuropil and pyramidal neurons of male mice. JOURNAL OF NEUROSCIENCE RESEARCH, 98(10), 2072-2095.Wiley. doi: 10.1002/jnr.24676.

Wellman, S.M., Guzman, K., Stieger, K.C., Brink, L.E., Sridhar, S., Dubaniewicz, M.T., Li, L., Cambi, F., & Kozai, T.D.Y. (2020). Cuprizone-induced oligodendrocyte loss and demyelination impairs recording performance of chronically implanted neural interfaces. BIOMATERIALS, 239, 119842.Elsevier. doi: 10.1016/j.biomaterials.2020.119842.

Yang, Q., Wu, B., Eles, J.R., Vazquez, A.L., Kozai, T.D.Y., & Cui, X.T. (2020). Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo. ADVANCED BIOSYSTEMS, 4(6), e1900287.Wiley. doi: 10.1002/adbi.201900287.

Baranov, S.V., Baranova, O.V., Yablonska, S., Suofu, Y., Vazquez, A.L., Kozai, T.D.Y., Cui, X.T., Ferrando, L.M., Larkin, T.M., Tyurina, Y.Y., Kagan, V.E., Carlisle, D.L., Kristal, B.S., & Friedlander, R.M. (2019). Mitochondria modulate programmed neuritic retraction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(2), 650-659.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1811021116.

Chen, K., Lam, S., & Kozai, T.D. (2019). What directions of improvements in electrode designs should we expect in the next 5–10 years?. Bioelectronics in Medicine, 2(3), 119-122.Taylor & Francis. doi: 10.2217/bem-2019-0023.

Eles, J.R., Vazquez, A.L., Kozai, T.D.Y., & Cui, X.T. (2019). Meningeal inflammatory response and fibrous tissue remodeling around intracortical implants: An in vivo two-photon imaging study. BIOMATERIALS, 195, 111-123.Elsevier. doi: 10.1016/j.biomaterials.2018.12.031.

Ereifej, E.S., Shell, C.E., Schofield, J.S., Charkhkar, H., Cuberovic, I., Dorval, A.D., Graczyk, E.L., Kozai, T.D.Y., Otto, K.J., Tyler, D.J., Welle, C.G., Widge, A.S., Zariffa, J., Moritz, C.T., Bourbeau, D.J., & Marasco, P.D. (2019). Neural engineering: the process, applications, and its role in the future of medicine. JOURNAL OF NEURAL ENGINEERING, 16(6), 063002.IOP Publishing. doi: 10.1088/1741-2552/ab4869.

Kozai, T.D.Y., & Purcell, E.K. (2019). BRAIN ELECTROPHYSIOLOGY Pipette-integrated microelectrodes. NATURE BIOMEDICAL ENGINEERING, 3(9), 682-683.Springer Nature. doi: 10.1038/s41551-019-0452-x.

Michelson, N.J., Eles, J.R., Vazquez, A.L., Ludwig, K.A., & Kozai, T.D.Y. (2019). Calcium activation of cortical neurons by continuous electrical stimulation: Frequency dependence, temporal fidelity, and activation density. JOURNAL OF NEUROSCIENCE RESEARCH, 97(5), 620-638.Wiley. doi: 10.1002/jnr.24370.

Stieger, K.C., Eles, J.R., Ludwig, K.A., & Kozai, T.D.Y. (2019). In vivo microstimulation with cathodic and anodic asymmetric waveforms modulates spatiotemporal calcium dynamics in cortical neuropil and pyramidal neurons of male mice. 2019.12.16.878892.Cold Spring Harbor Laboratory. doi: 10.1101/2019.12.16.878892.

Stocking, K.C., Vazquez, A.L., & Kozai, T.D.Y. (2019). Intracortical Neural Stimulation With Untethered, Ultrasmall Carbon Fiber Electrodes Mediated by the Photoelectric Effect. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 66(8), 2402-2412.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TBME.2018.2889832.

Wellman, S.M., Li, L., Yaxiaer, Y., McNamara, I., & Kozai, T.D.Y. (2019). Revealing Spatial and Temporal Patterns of Cell Death, Glial Proliferation, and Blood-Brain Barrier Dysfunction Around Implanted Intracortical Neural Interfaces. FRONTIERS IN NEUROSCIENCE, 13(MAY), 493.Frontiers. doi: 10.3389/fnins.2019.00493.

Cody, P.A., Eles, J.R., Lagenaur, C.F., Kozai, T.D.Y., & Cui, X.T. (2018). Unique electrophysiological and impedance signatures between encapsulation types: An analysis of biological Utah array failure and benefit of a biomimetic coating in a rat model. BIOMATERIALS, 161, 117-128.Elsevier. doi: 10.1016/j.biomaterials.2018.01.025.

Eles, J.R., Vazquez, A.L., Kozai, T.D.Y., & Cui, X.T. (2018). In vivo imaging of neuronal calcium during electrode implantation: Spatial and temporal mapping of damage and recovery. BIOMATERIALS, 174, 79-94.Elsevier. doi: 10.1016/j.biomaterials.2018.04.043.

Golabchi, A., Wu, B., Li, X., Carlisle, D.L., Kozai, T.D.Y., Friedlander, R.M., & Cui, X.T. (2018). Melatonin improves quality and longevity of chronic neural recording. BIOMATERIALS, 180, 225-239.Elsevier. doi: 10.1016/j.biomaterials.2018.07.026.

Iordanova, B., Vazquez, A., Kozai, T.D.Y., Fukuda, M., & Kim, S.G. (2018). Optogenetic investigation of the variable neurovascular coupling along the interhemispheric circuits. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 38(4), 627-640.SAGE Publications. doi: 10.1177/0271678X18755225.

Kozai, T.D.Y. (2018). The History and Horizons of Microscale Neural Interfaces. MICROMACHINES, 9(9), 445.MDPI. doi: 10.3390/mi9090445.

Michelson, N.J., & Kozai, T.D.Y. (2018). Isoflurane and ketamine differentially influence spontaneous and evoked laminar electrophysiology in mouse V1. JOURNAL OF NEUROPHYSIOLOGY, 120(5), 2232-2245.American Physiological Society. doi: 10.1152/jn.00299.2018.

Michelson, N.J., Eles, J.R., Vazquez, A.L., Ludwig, K.A., & Kozai, T.D. (2018). Calcium activation of cortical neurons by continuous electrical stimulation: Frequency-dependence, temporal fidelity and activation density. 338525.Cold Spring Harbor Laboratory. doi: 10.1101/338525.

Michelson, N.J., Vazquez, A.L., Eles, J.R., Salatino, J.W., Purcell, E.K., Williams, J.J., Cui, X.T., & Kozai, T.D.Y. (2018). Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface. JOURNAL OF NEURAL ENGINEERING, 15(3), 033001.IOP Publishing. doi: 10.1088/1741-2552/aa9dae.

Nicolai, E.N., Michelson, N.J., Settell, M.L., Hara, S.A., Trevathan, J.K., Asp, A.J., Stocking, K.C., Lujan, J.L., Kozai, T.D.Y., & Ludwig, K.A. (2018). Design Choices for Next-Generation Neurotechnology Can Impact Motion Artifact in Electrophysiological and Fast-Scan Cyclic Voltammetry Measurements. MICROMACHINES, 9(10), 494.MDPI. doi: 10.3390/mi9100494.

Salatino, J.W., Ludwig, K.A., Kozai, T.D.Y., & Purcell, E.K. (2018). Glial responses to implanted electrodes in the brain (vol 1, pg 862, 2017). NATURE BIOMEDICAL ENGINEERING, 2(1), 52.Springer Nature. doi: 10.1038/s41551-017-0177-7.

Trevathan, J.K., J., A., Nicolai, E.N., Trevathan, J.M., Kremer, N.A., Kozai, T.D., Cheng, D., Schachter, M., Nassi, J.J., Otte, S.L., Parker, J.G., Lujan, J.L., & Ludwig, K.A. (2018). Calcium imaging in freely-moving mice during electrical stimulation of deep brain structures. 460220.Cold Spring Harbor Laboratory. doi: 10.1101/460220.

Wellman, S.M., & Kozai, T.D.Y. (2018). In vivo spatiotemporal dynamics of NG2 glia activity caused by neural electrode implantation. BIOMATERIALS, 164, 121-133.Elsevier. doi: 10.1016/j.biomaterials.2018.02.037.

Wellman, S.M., Cambi, F., & Kozai, T.D.Y. (2018). The role of oligodendrocytes and their progenitors on neural interface technology: A novel perspective on tissue regeneration and repair. BIOMATERIALS, 183, 200-217.Elsevier. doi: 10.1016/j.biomaterials.2018.08.046.

Wellman, S.M., Eles, J.R., Ludwig, K.A., Seymour, J.P., Michelson, N.J., McFadden, W.E., Vazquez, A.L., & Kozai, T.D.Y. (2018). A Materials Roadmap to Functional Neural Interface Design. ADVANCED FUNCTIONAL MATERIALS, 28(12), 1701269.Wiley. doi: 10.1002/adfm.201701269.

Du, Z.J., Kolarcik, C.L., Kozai, T.D.Y., Luebben, S.D., Sapp, S.A., Zheng, X.S., Nabity, J.A., & Cui, X.T. (2017). Ultrasoft microwire neural electrodes improve chronic tissue integration. ACTA BIOMATERIALIA, 53, 46-58.Elsevier. doi: 10.1016/j.actbio.2017.02.010.

Eles, J.R., Vazquez, A.L., Snyder, N.R., Lagenaur, C., Murphy, M.C., Kozai, T.D.Y., & Cui, X.T. (2017). Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy. BIOMATERIALS, 113, 279-292.Elsevier. doi: 10.1016/j.biomaterials.2016.10.054.

Salatino, J.W., Ludwig, K.A., Kozai, T.D.Y., & Purcell, E.K. (2017). Glial responses to implanted electrodes in the brain. NATURE BIOMEDICAL ENGINEERING, 1(11), 862-877.Springer Nature. doi: 10.1038/s41551-017-0154-1.

Wellman, S.M., & Kozai, T.D.Y. (2017). Understanding the Inflammatory Tissue Reaction to Brain Implants To Improve Neurochemical Sensing Performance. ACS CHEMICAL NEUROSCIENCE, 8(12), 2578-2582.American Chemical Society (ACS). doi: 10.1021/acschemneuro.7b00403.

Khilwani, R., Gilgunn, P.J., Kozai, T.D.Y., Ong, X.C., Korkmaz, E., Gunalan, P.K., Cui, X.T., Fedder, G.K., & Ozdoganlar, O.B. (2016). Ultra-miniature ultra-compliant neural probes with dissolvable delivery needles: design, fabrication and characterization. BIOMEDICAL MICRODEVICES, 18(6), 97.Springer Nature. doi: 10.1007/s10544-016-0125-4.

Kozai, T.D.Y., Catt, K., Du, Z., Na, K., Srivannavit, O., Haque, R.U.M., Seymour, J., Wise, K.D., Yoon, E., & Cui, X.T. (2016). Chronic In Vivo Evaluation of PEDOT/CNT for Stable Neural Recordings. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 63(1), 111-119.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TBME.2015.2445713.

Kozai, T.D.Y., Eles, J.R., Vazquez, A.L., & Cui, X.T. (2016). Two-photon imaging of chronically implanted neural electrodes: Sealing methods and new insights. JOURNAL OF NEUROSCIENCE METHODS, 258, 46-55.Elsevier. doi: 10.1016/j.jneumeth.2015.10.007.

Kozai, T.D.Y., Jaquins-Gerstl, A.S., Vazquez, A.L., Michael, A.C., & Cui, X.T. (2016). Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo. BIOMATERIALS, 87, 157-169.Elsevier. doi: 10.1016/j.biomaterials.2016.02.013.

Patel, P.R., Zhang, H., Robbins, M.T., Nofar, J.B., Marshall, S.P., Kobylarek, M.J., Kozai, T.D.Y., Kotov, N.A., & Chestek, C.A. (2016). Chronic in vivo stability assessment of carbon fiber microelectrode arrays. JOURNAL OF NEURAL ENGINEERING, 13(6), 066002.IOP Publishing. doi: 10.1088/1741-2560/13/6/066002.

Alba, N.A., Du, Z.J., Catt, K.A., Kozai, T.D.Y., & Cui, X.T. (2015). In Vivo Electrochemical Analysis of a PEDOT/MWCNT Neural Electrode Coating. Biosensors, 5(4), 618-646.MDPI. doi: 10.3390/bios5040618.

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