headshot of Pratap Khanwilkar

Pratap Khanwilkar

Director of Master's Programs and Professor of Practice
prk38@pitt.edu
pratap@ignitionkey.biz
(412) 624-0403
Pratap Khanwilkar's Linked In Profile Bioengineering Department

overview

Four decades of transformational contributions and leadership in innovative medical technology advancement including innovation and commercialization.

4 breakthrough technologies advanced to help patients in cardiac, neurologic, orthopedic and drug delivery:
1) Fully maglev centrifugal long-term implantable LVADs (Left Ventricular Assist Devices) for late-stage heart failure- from concept to European First-In-Human clinical studies, US pivotal clinical trial for Bridge-To-Transplant and revenue generation. Founder/CEO of Salt Lake City-based start-up, MedQuest Products, with acquisition by NASDAQ: WHRT, TSX: WHT.
2) Next-generation long-term implantable neuromodulator allowing simultaneous blocking and stimulation w/o interference, a breakthrough with benchtop prototype productized through in vivo tests, human cadaver studies, controlled manufacturing and verification and validation leading to FDA Early Feasibility Study (EFS) IDE submitted. Founder/CEO of start-up Miran Medical.
3) Bioresorbable Magnesium alloy based orthopedics: These prevent the need for re-surgeries when Titanium and Stainless steel alloys are implanted to fix a fracture and then need to be explanted with a follow-on surgery. Advised and managed industry/business focus for NSF Engineering Research Center. Plates and screws based on resorbable Mg are now commercialized by 2 companies in Germany and 1 in the US.
4) Oral delivery of biological drugs: A 'holy grail' of pharma, part of leadership team at medtech incubator InCube Labs LLC, which incubated Rani Therapeutics and took it public on NASDAQ for > $500MM market cap in July 2021. Contributed to the early clinical studies of the Rani Pill to demonstrate proof of concept for this never-done-before drug delivery platform.

18 start-ups, 3 exits, >$500MM raised in non-dilutive/dilutive funding.


Founder/CEO, CTO and Board Chair to Public Company Officer and Angel Investor.

Team formation, organizational development and ecosystem advancement worldwide creating and coaching leaders in USA, Europe, China, Japan, Canada, South Korea, Australia, and India.

about

(2023) JTM Gibson Alumni Excellence Award, Mayo College, Ajmer.

(2011) Invited session reporter and participant.

(2010) Utah's Bionic Valley Produces Another Life-Changing Medical Device, Spotlight on WorldHeart and the Levacor VAD, Economic Development Corporation of Utah.

(2008) Spotlight, Utah CEO Magazine, pp. 24-25.

(2008) Pathfinder 2008 Annual Award for an individual for innovation- Recognizes annually one inventor in State of Utah who has successfully developed original ideas and technologies in Utah-based universities that affect our world. Ninth recipient of this award..

(2007) Invited spotlight on WorldHeart to represent Utah's medical device industry, 1st Utah Technology Council Life Science Newsletter.

(2006) International Council of Medical Technologies (ICMT) Award presented to WorldHeart for 'Most Significant Contributions to Advancement of Rotary Blood Pumps'.

(2006) '50 Companies to Watch', WorldHeart recognition by Medical Device and Diagnostic Industry (MD&DI) magazine, published by Canon Communications.

(2006) Utah Innovation Award winner in Medical Devices for Levacor LVAD, 2006, Finalist (2003-2004).

(2004) vSpring 100: Inaugural Top 100 Entrepreneurs in Utah, vSpring Capital.

(2000 - 2002) Utah 100 Fastest Growing Companies Award for MedQuest Products Inc., Mountain West Venture Group, 2000, 2001 & 2002.

(1999) Blue Chip Enterprise Award to MedQuest Products, U.S. Chamber of Commerce.

(1995 - 2010) Sezai Innovation Award, International Society Rotary Blood Pumps Annual Congress, 1995 (Houston), 1999 (Tokyo) and 2010 (Berlin). Only 3-time recipient of this annual award..

(1992) Phi Kappa Phi, Beta Gamma Sigma, and Dean's Scholar, David Eccles School of Business, University of Utah.

(1992) George Hays Brown National Marketing Scholar Award, American Marketing Association.

(1986) Curtis Johnson Memorial Award: Outstanding Bioengineering Graduate Student, Department of Bioengineering, University of Utah.

Ph.D., Bioengineering, University of Utah, 2005

M.B.A, Business Administration, University of Utah, 1992

M.S., Bioengineering, University of Utah, 1987

B. Tech., Electrical Engineering, Indian Institute of Technology, 1984

Cai, H., Morgan, T., Pace, N., Shen, B., Wang, J., Roppolo, J.R., Horlen, K., Khanwilkar, P., de Groat, W.C., & Tai, C. (2019). Low pressure voiding induced by a novel implantable pudendal nerve stimulator. Neurourol Urodyn, 38(5), 1241-1249.Wiley. doi: 10.1002/nau.23994.

Kumar, A., & Khanwilkar, P.S. (2011). Long-term implantable Ventricular Assist Devices (VADs) and Total Artificial Hearts (TAHs). In Comprehensive Biomaterials. 6, (pp. 389-401).Elsevier.

Bearnson, G.B., Jacobs, G.B., Kirk, J., Khanwilkar, P.S., Nelson, K.E., & Long, J.W. (2006). HeartQuest ventricular assist device magnetically levitated centrifugal blood pump. Artif Organs, 30(5), 339-346.Wiley. doi: 10.1111/j.1525-1594.2006.00223.x.

Borovetz, H.S., Badylak, S., Boston, J.R., Johnson, C., Kormos, R., Kameneva, M.V., Simaan, M., Snyder, T.A., Tsukui, H., Wagner, W.R., Woolley, J., Antaki, J., Diao, C., Vandenberghe, S., Keller, B., Morell, V., Wearden, P., Webber, S., Gardiner, J., Li, C.M., Paden, D., Paden, B., Snyder, S., Wu, J., Bearnson, G., Hawkins, J.A., Jacobs, G., Kirk, J., Khanwilkar, P., Kouretas, P.C., Long, J., & Shaddy, R.E. (2006). Towards the development of a pediatric ventricular assist device. Cell Transplant, 15 Suppl 1(1_suppl), S69-S74.SAGE Publications. doi: 10.3727/000000006783982304.

Wearden, P.D., Morell, V.O., Keller, B.B., Webber, S.A., Borovetz, H.S., Badylak, S.F., Boston, J.R., Kormos, R.L., Kameneva, M.V., Simaan, M., Snyder, T.A., Tsukui, H., Wagner, W.R., Antaki, J.F., Diao, C., Vandenberghe, S., Gardiner, J., Li, C.M., Noh, D., Paden, D., Paden, B., Wu, J., Bearnson, G.B., Jacobs, G., Kirk, J., Khanwilkar, P., Long, J.W., Miles, S., Hawkins, J.A., Kouretas, P.C., & Shaddy, R.E. (2006). The PediaFlow™ Pediatric Ventricular Assist Device. Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual, 9(1), 92-98.Elsevier BV. doi: 10.1053/j.pcsu.2006.02.001.

Wearden, P.D., Morell, V.O., Keller, B.B., Webber, S.A., Borovetz, H.S., Badylak, S.F., Boston, J.R., Kormos, R.L., Kameneva, M.V., Simaan, M., Snyder, T.A., Tsukui, H., Wagner, W.R., Antaki, J.F., Diao, C., Vandenberghe, S., Gardiner, J., Li, C.M., Noh, D., Paden, D., Paden, B., Wu, J., Bearnson, G.B., Jacobs, G., Kirk, J., Khanwilkar, P., Long, J.W., Miles, S., Hawkins, J.A., Kouretas, P.C., & Shaddy, R.E. (2006). The PediaFlow pediatric ventricular assist device. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu, 9(1), 92-98.Elsevier. doi: 10.1053/j.pcsu.2006.02.001.

Anderson, J.B., Wood, H.G., Allaire, P.E., Bearnson, G., & Khanwilkar, P. (2000). Computational flow study of the continuous flow ventricular assist device, prototype number 3 blood pump. Artif Organs, 24(5), 377-385.Wiley. doi: 10.1046/j.1525-1594.2000.06442.x.

Baloh, M.J., Allaire, P.E., Hilton, E.F., Wei, N., Baun, D., Flack, R.D., Olson, D.B., Bearnson, G.B., & Khanwilkar, P.S. (1999). A magnetic bearing system for a continuous ventricular assist device. ASAIO J, 45(5), 450-454.Wolters Kluwer. doi: 10.1097/00002480-199909000-00016.

Baloh, M.J., Allaire, P.E., Hilton, E.F., Wei, N., Olsen, D.B., Bearnson, G.B., & Khanwilkar, P.S. (1999). Characterization of a magnetic bearing system and fluid properties for a continuous flow ventricular assist device. Artif Organs, 23(8), 792-796.Wiley. doi: 10.1046/j.1525-1594.1999.06425.x.

Hilton, E.F., Allaire, P.E., Wei, N., Baloh, M.J., Bearnson, G., Olsen, D.B., & Khanwilkar, P. (1999). Test controller design, implementation, and performance for a magnetic suspension continuous flow ventricular assist device. Artif Organs, 23(8), 785-791.Wiley. doi: 10.1046/j.1525-1594.1999.06424.x.

Waters, T., Allaire, P., Tao, G., Adams, M., Bearnson, G., Wei, N., Hilton, E., Baloh, M., Olsen, D., & Khanwilkar, P. (1999). Motor feedback physiological control for a continuous flow ventricular assist device. Artif Organs, 23(6), 480-486.Wiley. doi: 10.1046/j.1525-1594.1999.06386.x.

Allaire, P., Hilton, E., Baloh, M., Maslen, E., Bearnson, G., Noh, D., Khanwilkar, P., & Olsen, D. (1998). Performance of a continuous flow ventricular assist device: magnetic bearing design, construction, and testing. Artif Organs, 22(6), 475-480.Wiley. doi: 10.1046/j.1525-1594.1998.06095.x.

Bearnson, G.B., Olsen, D.B., Khanwilkar, P.S., Long, J.W., Sinnott, M., Kumar, A., Allaire, P.E., Baloh, M., & Decker, J. (1998). Implantable centrifugal pump with hybrid magnetic bearings. ASAIO J, 44(5), M733-M736.Wolters Kluwer. doi: 10.1097/00002480-199809000-00088.

Maslen, E.H., Bearnson, G.B., Allaire, P.E., Flack, R.H., Baloh, M., Hilton, E., Noh, M.D., Olsen, D.B., Khanwilkar, P.S., & Long, J.D. (1998). Feedback control applications in artificial hearts. IEEE CONTROL SYSTEMS MAGAZINE, 18(6), 26-34.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/37.736009.

Hilton, E.F., Allaire, P.E., Baloh, M.J., Maslen, E., Bearnson, G., Khanwilkar, P., & Olsen, D. (1997). Magnetic suspension controls for a new continuous flow ventricular assist device. ASAIO J, 43(5), M598-M603.Wolters Kluwer. doi: 10.1097/00002480-199709000-00054.

Kim, H.C., Khanwilkar, P.S., Bearnson, G.B., & Olsen, D.B. (1997). Development of a microcontroller-based automatic control system for the electrohydraulic total artificial heart. IEEE Trans Biomed Eng, 44(1), 77-89.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/10.553715.

Bearnson, G.B., Maslen, E.H., Olsen, D.B., Allaire, P.E., Khanwilkar, P.S., Long, J.W., & Kim, H.C. (1996). Development of a prototype magnetically suspended rotor ventricular assist device. ASAIO J, 42(4), 275-281.Wolters Kluwer. doi: 10.1097/00002480-199642040-00009.

Bearnson, G.B., Olsen, D.B., Khanwilkar, P.S., Long, J.W., Allaire, P.E., & Maslen, E.H. (1996). Pulsatile operation of a centrifugal ventricular assist device with magnetic bearings. ASAIO J, 42(5), M620-M624.Wolters Kluwer. doi: 10.1097/00002480-199609000-00062.

Khanwilkar, P., Olsen, D., Bearnson, G., Allaire, P., Maslen, E., Flack, R., & Long, J. (1996). Using hybrid magnetic bearings to completely suspend the impeller of a ventricular assist device. Artif Organs, 20(6), 597-604.Wiley. doi: 10.1111/j.1525-1594.1996.tb04488.x.

Kim, H.C., Bearnson, G.B., Khanwilkar, P.S., Olsen, D.B., Maslen, E.H., & Allaire, P.E. (1995). In vitro characterization of a magnetically suspended continuous flow ventricular assist device. ASAIO J, 41(3), M359-M364.Wolters Kluwer. doi: 10.1097/00002480-199507000-00031.

Kim, H.C., Park, S.K., Hindrichs, H.L., Bearnson, G.B., Khanwilkar, P.S., & Olsen, D.B. (1995). Noninvasive diagnosis of mechanical failure of the implanted total artificial heart using neural network analysis of acoustic signals. ASAIO J, 41(3), M271-M276.Wolters Kluwer. doi: 10.1097/00002480-199507000-00010.

Chiang, B.Y., Pantalos, G., Burns, G.L., Long, J.W., Khanwilkar, P.S., Everett, S.D., Mohammad, S.F., & Olsen, D.B. (1994). Anaerobic threshold in total artificial heart animals. ASAIO J, 40(3), M335-M338.Wolters Kluwer. doi: 10.1097/00002480-199407000-00019.

Chiang, B.Y., Pantalos, G.M., Burns, G.L., Long, J.W., Khanwilkar, P.S., Everett, S.D., Mohammad, S.F., & Olsen, D.B. (1994). Oxygen metabolism in animals with total artificial hearts. ASAIO J, 40(3), M510-M513.Wolters Kluwer. doi: 10.1097/00002480-199407000-00052.

Bearson, G.B., Krivoy, S.R., Jarmin, R.D., Fratto, J.R., Khanwilkar, P., Crump, K.R., & Smith, K.D. (1993). Electronics development for the Utah electrohydraulic total artificial heart. IEEE Symposium on Computer-Based Medical Systems, 247-252.

Kim, H.C., Khanwilkar, P.S., Long, J.W., & Olsen, D.B. (1993). Adaptive full-ejection point detection for automatic control of the electrohydraulic total artificial heart. ASAIO J, 39(4), 899-903.Wolters Kluwer. doi: 10.1097/00002480-199310000-00014.

Tatsumi, E., Khanwilkar, P.S., Rowles, J.R., Chiang, B.Y., Burns, G.L., Long, J.W., Hansen, A.C., Holfert, J.W., Bearnson, G.B., & Crump, K.R. (1993). In vivo long-term evaluation of the Utah electrohydraulic total artificial heart. ASAIO J, 39(3), M373-M380.Wolters Kluwer. doi: 10.1097/00002480-199307000-00044.

Rowles, J.R., Khanwilkar, P.S., Diegel, P.D., Hansen, A.C., Bearnson, G.B., Smith, K.D., Tatsumi, E., & Olsen, D.B. (1992). Development of a totally implantable artificial heart. ASAIO J, 38(3), M713-M716.Wolters Kluwer. doi: 10.1097/00002480-199207000-00131.

Tatsumi, E., Diegel, P.D., Holfert, J.W., Dew, P.A., Crump, K.R., Hansen, A.C., Khanwilkar, P.S., Rowles, J.R., & Olsen, D.B. (1992). A blood pump with an interatrial shunt for use as an electrohydraulic total artificial heart. ASAIO J, 38(3), M425-M430.Wolters Kluwer. doi: 10.1097/00002480-199207000-00069.

Khanwilkar, P., Kinoshita, M., Hansen, A., White, K., & Olsen, D. (1991). Determination of Atrial Shunt Size to balance the Electrohydraulic TAH. 37(3).

Kim, H.C., Khanwilkar, P.S., Crump, K.C., Smith, K.D., Bearnson, G.B., & Olsen, D.B. (1991). Development of an automatic control algorithm for the electrohydraulic total artificial heart without transducers. ASAIO Trans, 37(3), M501-M503.

Kinoshita, M., Hansen, C.A., Khanwilkar, P.S., White, K.R., & Olsen, D.B. (1991). Determination of atrial shunt size needed to balance an electrohydraulic total artificial heart. ASAIO Trans, 37(3), M264-M265.

Olsen, D.B., White, R.K., Long, J.W., & Khanwilkar, P.S. (1991). Right-left ventricular output balance in the totally implantable artificial heart. Int J Artif Organs, 14(6), 359-364.SAGE Publications. doi: 10.1177/039139889101400607.

Crump, K.R., Khanwilkar, P.S., Long, J.W., Holfert, J.W., & Olsen, D.B. (1990). In vitro analysis of an atrial shunt in balancing an electrohydraulic total artificial heart. ASAIO Trans, 36(3), M254-M257.

Long, J.W., Khanwilkar, P., Crump, K.R., Pantalos, G.M., Kinoshita, M., Kim, H.C., & Olsen, D.B. (1990). Right-left ventricular balance in implanted electrically powered artificial hearts. ASAIO Trans, 36(3), M287-M290.

Paden, B.E., Wu, J., Noh, M.D., Paden, D., Ricci, M., Snyder, S., Maul, T.M., Webber, S., Shu, F., Verkaik, J., Khanwilkar, P., Boston, J.R., Antaki, J.F., Keller, B.B., Kameneva, M.V., & Borovetz, H.S. (2008). The PediaFlow Pediatric Ventricular Assist Device. In ASME 2008 3rd Frontiers in Biomedical Devices Conference, (pp. 53-54).ASME International. doi: 10.1115/biomed2008-38042.

Bearnson, G., Diegel, P., Khanwilkar, P., Allaire, P., Ludlow, J., Cooley, D., Long, J.W., Kumar, B.A., Pantalos, G., Wood, H., & Olsen, D. (2000). PROGRESS ON THE HEARTQUESTTM VAD — A CENTRIFUGAL PUMP WITH MAGNETICALLY SUSPENDED ROTOR. Poster session presented at the meeting of ASAIO Journal, 46(2):192.

Bearnson, G.B., Hansen, A.C., Khanwilkar, P., & Olsen, D.B. (1993). Control of an electrohydraulic artificial heart using flow estimation. In Proceedings of the Annual Conference on Engineering in Medicine and Biology, 15(pt 2), (pp. 916-917).

Sinnott, M.M., Fratto, J.R., & Khanwilkar, P. (1992). Reliability testing of bearings used in the electrohydraulic total artificial heart. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, 22, (pp. 513-516).

Khanwilkar, P.S., Kinoshita, M., Hansen, A.C., Kim, H.C., White, R.K., Crump, K.R., & Olsen, D.B. (1991). An inter-atrial shunt used to balance the output of an electrohydraulic total artificial heart: Chronic in vivo results. In Proceedings of the Annual Conference on Engineering in Medicine and Biology, 13(pt 5), (pp. 2085-2086).

Khanwilkar, P.S., Crump, K.R., Bearnson, G.B., Smith, J.K., & Olsen, D.B. (1989). Development of the physiological control scheme for an electrohydraulic total artificial heart. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 11 pt 1, (pp. 149-150).