headshot of Mo Reza Ebrahimkhani

Mo Reza Ebrahimkhani

Associate Professor
Bioengineering Department


Our research combines systems and synthetic biology to program tissue development and regeneration.
For more information please check out : Laboratory for Synthetic Biology and Regenerative Medicine https://www.ebrahimkhanilab.com


Pandelakis, M., Delgado, E., & Ebrahimkhani, M.R. (2020). CRISPR-Based Synthetic Transcription Factors In Vivo: The Future of Therapeutic Cellular Programming. Cell Syst, 10(1), 1-14.Elsevier BV. doi: 10.1016/j.cels.2019.10.003.

Ebrahimkhani, M.R., & Ebisuya, M. (2019). Synthetic developmental biology: build and control multicellular systems. Curr Opin Chem Biol, 52, 9-15.Elsevier BV. doi: 10.1016/j.cbpa.2019.04.006.

Velazquez, J.J., Su, E., Cahan, P., & Ebrahimkhani, M.R. (2018). Programming Morphogenesis through Systems and Synthetic Biology. Trends Biotechnol, 36(4), 415-429.Elsevier BV. doi: 10.1016/j.tibtech.2017.11.003.

Yeo, N.C., Chavez, A., Lance-Byrne, A., Chan, Y., Menn, D., Milanova, D., Kuo, C.C., Guo, X., Sharma, S., Tung, A., Cecchi, R.J., Tuttle, M., Pradhan, S., Lim, E.T., Davidsohn, N., Ebrahimkhani, M.R., Collins, J.J., Lewis, N.E., Kiani, S., & Church, G.M. (2018). An enhanced CRISPR repressor for targeted mammalian gene regulation. Nat Methods, 15(8), 611-616.Springer Science and Business Media LLC. doi: 10.1038/s41592-018-0048-5.

Lu, T., Dwyer, D.J., Acar, M., Barrick, J.E., Venturelli, O., & Ebrahimkhani, M. (2017). What Is the Role of Circuit Design in the Advancement of Synthetic Biology? Part 2. CELL SYSTEMS, 4(5), 476-477.Elsevier BV. doi: 10.1016/j.cels.2017.05.006.

Guye, P., Ebrahimkhani, M.R., Kipniss, N., Velazquez, J.J., Schoenfeld, E., Kiani, S., Griffith, L.G., & Weiss, R. (2016). Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Nat Commun, 7(1), 10243.Springer Science and Business Media LLC. doi: 10.1038/ncomms10243.

Ebrahimkhani, M.R., Velzaquez, J., Legraw, R., Moghadam, F., Kilbourne, J., & Kiani, S. (2019). Genetically guided engineering of human liver tissue from pluripotent stem cells. In Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, 40, (p. 976).

Velazquez, J., Kostes, W., Go, S., Pradhan, S., Kiani, S., Rakela, J., & Ebrahimkhani, M. (2017). Engineering Advanced Biliary Organoids with Mesenchymal Niche from Human Induced Pluripotent Stem Cells. In HEPATOLOGY, 66, (p. 379A).

Ebrahimkhani, M.R., Maroteaux, L., Mann, D.A., & Oakley, F. (2008). Serotonin 2B receptor: A novel negative regulator of liver growth. In JOURNAL OF HEPATOLOGY, 48, (pp. S59-S60).Elsevier BV. doi: 10.1016/S0168-8278(08)60141-5.