headshot of Mark Gartner

Mark Gartner

Professor
gartnerm@pitt.edu
(412) 383-9598
Ension Company Site Bioengineering Department

overview

Mark J. Gartner - M.E. Mechanical Engineering and Bioengineering, Carnegie Mellon, M.B.A. Finance and Entrepreneurship, University of Pittsburgh, Ph.D. Bioengineering, Carnegie Mellon.

Dr. Gartner began his career in medical product design and development in 1988 as a clinical bioengineer responsible for various facets of the mechanical circulatory support program at the University of Pittsburgh Medical Center. His work included direct clinical care of patients supported by various types of mechanical circulatory support devices including total artificial hearts and ventricular assist devices as well as design of several types of integrated pump-oxygenator devices. Dr. Gartner was director of the Pittsburgh chronic artificial lung program which focused on development of an active mixing pump-oxygenator developed in his laboratory for long-term ambulatory ECMO/ECLS. He has also extensively collaborated with clinical colleagues in the design and development of minimally invasive surgical tools and engineered biocompatible surface treatments for both blood compatibility and infection resistance.

In 2003, Dr. Gartner developed and has since taught the Senior Design course sequence in the Department of Bioengineering at the University of Pittsburgh. This two-semester capstone course sequence requires Bioengineering students to synthesize and extend principles from prior coursework toward the design or redesign of a medical product. The course requires that students interact with clinicians as part of the overall course goal of understanding the unique challenges of working within clinical medicine. Under the guidance of clinical, academic, and industrial mentors, students develop competing designs, fabricate prototypes, and evaluate whether the functional specifications are achieved. Their work is performed under the appropriate facets of FDA's Quality System Regulation and evaluated in accordance with FDA's Quality System Inspection Technique.

about

Hussain, A., Curry, B., Cahalan, L., Minkin, S., Gartner, M., & Cahalan, P. (2016). Development and in vitro evaluation of infection resistant materials: A novel surface modification process for silicone and Dacron. J Biomater Appl, 30(7), 1103-1113.SAGE Publications. doi: 10.1177/0885328215607378.

Ludwig, D.R., Menon, P.G., Fill, B., Gartner, M., & Schwartzman, D. (2015). A novel toolkit to improve percutaneous subxiphoid needle access to the healthy pericardial sac. J Cardiovasc Electrophysiol, 26(5), 576-580.Wiley. doi: 10.1111/jce.12643.

Johnson, G., Curry, B., Cahalan, L., Prater, R., Beeler, M., Gartner, M., Biggerstaff, J., & Cahalan, P. (2013). In vitro assessment of blood compatibility: residual and dynamic markers of cellular activation. J Biomater Appl, 27(8), 925-936.SAGE Publications. doi: 10.1177/0885328211428525.

Johnson, G., Curry, B., Cahalan, L., Prater, R., Biggerstaff, J., Hussain, A., Gartner, M., & Cahalan, P. (2013). Effects of surface-bound and intravenously administered heparin on cell-surface interactions: inflammation and coagulation. Perfusion, 28(3), 263-271.SAGE Publications. doi: 10.1177/0267659113475834.

Baldwin, J.T., Borovetz, H.S., Duncan, B.W., Gartner, M.J., Jarvik, R.K., & Weiss, W.J. (2011). The national heart, lung, and blood institute pediatric circulatory support program: a summary of the 5-year experience. Circulation, 123(11), 1233-1240.Wolters Kluwer. doi: 10.1161/CIRCULATIONAHA.110.978023.

Pantalos, G.M., Horrell, T., Merkley, T., Sahetya, S., Speakman, J., Johnson, G., & Gartner, M. (2009). In vitro characterization and performance testing of the ension pediatric cardiopulmonary assist system. ASAIO J, 55(3), 282-286.Wolters Kluwer. doi: 10.1097/MAT.0b013e3181909d76.

Fill, B., Gartner, M., Johnson, G., Horner, M., & Ma, J. (2008). Computational fluid flow and mass transfer of a functionally integrated pediatric pump-oxygenator configuration. ASAIO J, 54(2), 214-219.Wolters Kluwer. doi: 10.1097/MAT.0b013e3181648d80.

Samuels, L.E., Shemanski, K.A., Casanova-Ghosh, E., Hagan, K., Garwood, P., & Droogan, C. (2008). Hybrid ventricular assist device: Heartmate XVE LVAD and Abiomed AB5000 RVAD. ASAIO J, 54(3), 332-334.Wolters Kluwer. doi: 10.1097/MAT.0b013e318172eeb8.

Giridharan, G.A., Koenig, S.C., Mitchell, M., Gartner, M., & Pantalos, G.M. (2007). A computer model of the pediatric circulatory system for testing pediatric assist devices. ASAIO J, 53(1), 74-81.Wolters Kluwer. doi: 10.1097/01.mat.0000247154.02260.30.

Pantalos, G.M., Giridharan, G., Colyer, J., Mitchell, M., Speakman, J., Lucci, C., Johnson, G., Gartner, M., & Koenig, S.C. (2007). Effect of continuous and pulsatile flow left ventricular assist on pulsatility in a pediatric animal model of left ventricular dysfunction: pilot observations. ASAIO J, 53(3), 385-391.Wolters Kluwer. doi: 10.1097/MAT.0b013e318050d210.

Baldwin, J.T., Borovetz, H.S., Duncan, B.W., Gartner, M.J., Jarvik, R.K., Weiss, W.J., & Hoke, T.R. (2006). The National Heart, Lung, and Blood Institute Pediatric Circulatory Support Program. Circulation, 113(1), 147-155.Wolters Kluwer. doi: 10.1161/CIRCULATIONAHA.105.571422.

Wu, Z.J., Gartner, M., Litwak, K.N., & Griffith, B.P. (2005). Progress toward an ambulatory pump-lung. J Thorac Cardiovasc Surg, 130(4), 973-978.Elsevier. doi: 10.1016/j.jtcvs.2005.04.032.

Gage, K.L., Gartner, M.J., Burgreen, G.W., & Wagner, W.R. (2002). Predicting membrane oxygenator pressure drop using computational fluid dynamics. Artif Organs, 26(7), 600-607.Wiley. doi: 10.1046/j.1525-1594.2002.07082.x.

Vorp, D.A., Gartner, M.J., & Keynton, R.S. (2001). Vascular Applications of Micro- and Nanotechnology. Journal of Vascular and Interventional Radiology, 12(1), p236-p240.Elsevier. doi: 10.1016/s1051-0443(01)70132-7.

Gartner, M., Borovetz, H., Litwak, P., Reeder, G., & Griffith, B. (2000). Development of an active mixing paracorporeal oxygenator. Annals of Biomedical Engineering, 28(SUPPL. 1).

Gartner, M.J., Wilhelm, C.R., Gage, K.L., Fabrizio, M.C., & Wagner, W.R. (2000). Modeling flow effects on thrombotic deposition in a membrane oxygenator. Artif Organs, 24(1), 29-36.Wiley. doi: 10.1046/j.1525-1594.2000.06384.x.

Gartner, M.J., Litwak, P., Borovetz, H.S., & Griffith, B.P. (2002). Development of a pumping artificial lung. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, (pp. 1589-1590).

Antaki, J.F., Rajagopal, K.R., Rosenthal, M.S., Vorp, D.A., Gartner, M.J., & Borovetz, H.S. (1991). An experimental and theoretical model for the passive biomechanical properties of the intact heart. In Proceedings of the Annual Conference on Engineering in Medicine and Biology, 13(pt 5), (pp. 2058-2059).

Antaki, J.F., Kormos, R.L., Gartner, M.J., Griffith, B.P., & Borovetz, H.S. (1989). Right ventricular pressure - segment relations following left ventricular assist in man: a case study. In American Society of Mechanical Engineers, Applied Mechanics Division, AMD, 98, (pp. 269-272).

Research interests

bioactive surface treatment...
Medical product design and...
minimally invasive surgical tool...
Pediatric medical product design