PhD, University of Colorado Anschutz Medical Campus, 2011 - 2015
MS, National Tsing Hua University, 2006 - 2008
BS, National Dong Hwa University, 2002 - 2006
Rao, M., Liu, C.C., Wang, S., & Chang, K.C. (2025). Generating ESC-Derived RGCs for Cell Replacement Therapy. Methods Mol Biol, 2848, 187-196.Springer Nature. doi: 10.1007/978-1-0716-4087-6_12.
Alahmari, H., Liu, C.C., Rubin, E., Lin, V.Y., Rodriguez, P., & Chang, K.C. (2024). Vitamin C alleviates hyperglycemic stress in retinal pigment epithelial cells. Mol Biol Rep, 51(1), 637.Springer Nature. doi: 10.1007/s11033-024-09595-2.
Cameron, E.G., Nahmou, M., Toth, A.B., Heo, L., Tanasa, B., Dalal, R., Yan, W., Nallagatla, P., Xia, X., Hay, S., Knasel, C., Stiles, T.L., Douglas, C., Atkins, M., Sun, C., Ashouri, M., Bian, M., Chang, K.C., Russano, K., Shah, S., Woodworth, M.B., Galvao, J., Nair, R.V., Kapiloff, M.S., & Goldberg, J.L. (2024). A molecular switch for neuroprotective astrocyte reactivity. Nature, 626(7999), 574-582.Springer Nature. doi: 10.1038/s41586-023-06935-3.
Chen, T.E., Lo, J., Huang, S.P., Chang, K.C., Liu, P.L., Wu, H.E., Chen, Y.R., Chang, Y.C., Liu, C.C., Lee, P.Y., Lai, Y.H., Wu, P.C., Wang, S.C., & Li, C.Y. (2024). Glaucine inhibits hypoxia-induced angiogenesis and attenuates LPS-induced inflammation in human retinal pigment epithelial ARPE-19 cells. Eur J Pharmacol, 981, 176883.Elsevier. doi: 10.1016/j.ejphar.2024.176883.
Huang, Y.K., Wang, T.M., Chen, C.Y., Li, C.Y., Wang, S.C., Irshad, K., Pan, Y., & Chang, K.C. (2024). The role of ALDH1A1 in glioblastoma proliferation and invasion. Chem Biol Interact, 402, 111202.Elsevier. doi: 10.1016/j.cbi.2024.111202.
Luo, Z., & Chang, K.C. (2024). Cell replacement with stem cell-derived retinal ganglion cells from different protocols. Neural Regen Res, 19(4), 807-810.Wolters Kluwer. doi: 10.4103/1673-5374.381494.
Luo, Z., Shah, S., Tanasa, B., Chang, K.C., & Goldberg, J.L. (2024). Gene regulatory roles of growth and differentiation factors in retinal development. iScience, 27(6), 110100.Elsevier. doi: 10.1016/j.isci.2024.110100.
Rao, M., & Chang, K.C. (2024). Aldose reductase is a potential therapeutic target for neurodegeneration. Chem Biol Interact, 389, 110856.Elsevier. doi: 10.1016/j.cbi.2024.110856.
Rao, M., Luo, Z., Liu, C.C., Chen, C.Y., Wang, S., Nahmou, M., Tanasa, B., Virmani, A., Byrne, L., Goldberg, J.L., Sahel, J.A., & Chang, K.C. (2024). Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration. Acta Neuropathol Commun, 12(1), 204.Springer Nature. doi: 10.1186/s40478-024-01917-6.
Wang, S., Chen, C.Y., Liu, C.C., Stavropoulos, D., Rao, M., Petrash, J.M., & Chang, K.C. (2024). GDF-15 Attenuates the Epithelium-Mesenchymal Transition and Alleviates TGFβ2-Induced Lens Opacity. Transl Vis Sci Technol, 13(7), 2.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/tvst.13.7.2.
Chien, H.T., Li, C.Y., Su, W.H., Chang, K.C., Chen, C.S., Liu, Y.T., Chen, C.Y., Dai, C.Y., & Wang, S.C. (2023). Multi-omics profiling of chemotactic characteristics of brain microglia and astrocytoma. Life Sci, 330, 121855.Elsevier. doi: 10.1016/j.lfs.2023.121855.
Huang, Y.K., Chang, K.C., Li, C.Y., Lieu, A.S., & Lin, C.L. (2023). AKR1B1 Represses Glioma Cell Proliferation through p38 MAPK-Mediated Bcl-2/BAX/Caspase-3 Apoptotic Signaling Pathways. Curr Issues Mol Biol, 45(4), 3391-3405.MDPI. doi: 10.3390/cimb45040222.
Irshad, K., Huang, Y.K., Rodriguez, P., Lo, J., Aghoghovwia, B.E., Pan, Y., & Chang, K.C. (2023). The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma. Brain Sci, 13(10), 1424.MDPI. doi: 10.3390/brainsci13101424.
Lo, J., Mehta, K., Dhillon, A., Huang, Y.K., Luo, Z., Nam, M.H., Al Diri, I., & Chang, K.C. (2023). Therapeutic strategies for glaucoma and optic neuropathies. Mol Aspects Med, 94, 101219.Elsevier. doi: 10.1016/j.mam.2023.101219.
Lo, J., Wu, H.E., Liu, C.C., Chang, K.C., Lee, P.Y., Liu, P.L., Huang, S.P., Wu, P.C., Lin, T.C., Lai, Y.H., Chang, Y.C., Chen, Y.R., Lee, S.I., Huang, Y.K., Wang, S.C., & Li, C.Y. (2023). Nordalbergin Exerts Anti-Neuroinflammatory Effects by Attenuating MAPK Signaling Pathway, NLRP3 Inflammasome Activation and ROS Production in LPS-Stimulated BV2 Microglia. Int J Mol Sci, 24(8), 7300.MDPI. doi: 10.3390/ijms24087300.
Ning, K., Bhuckory, M.B., Lo, C.H., Sendayen, B.E., Kowal, T.J., Chen, M., Bansal, R., Chang, K.C., Vollrath, D., Berbari, N.F., Mahajan, V.B., Hu, Y., & Sun, Y. (2023). Cilia-associated wound repair mediated by IFT88 in retinal pigment epithelium. Sci Rep, 13(1), 8205.Springer Nature. doi: 10.1038/s41598-023-35099-3.
Rao, M., Huang, Y.K., Liu, C.C., Meadows, C., Cheng, H.C., Zhou, M., Chen, Y.C., Xia, X., Goldberg, J.L., Williams, A.M., Kuwajima, T., & Chang, K.C. (2023). Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation. Sci Rep, 13(1), 5592.Springer Nature. doi: 10.1038/s41598-023-32702-5.
Chang, K.C. (2022). Influence of Sox protein SUMOylation on neural development and regeneration. Neural Regen Res, 17(3), 477-481.Wolters Kluwer. doi: 10.4103/1673-5374.320968.
Chang, K.C., Liu, P.F., Chang, C.H., Lin, Y.C., Chen, Y.J., & Shu, C.W. (2022). The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases. Cell Biosci, 12(1), 1.Springer Nature. doi: 10.1186/s13578-021-00736-9.
Huang, Y.K., Chen, Y.C., Liu, C.C., Cheng, H.C., Tu, A.T., & Chang, K.C. (2022). Cerebral Complications of Snakebite Envenoming: Case Studies. Toxins (Basel), 14(7), 436.MDPI. doi: 10.3390/toxins14070436.
Huang, Y.K., Liu, C.C., Wang, S., Cheng, H.C., Meadows, C., & Chang, K.C. (2022). The Role of Aldose Reductase in Beta-Amyloid-Induced Microglia Activation. Int J Mol Sci, 23(23), 15088.MDPI. doi: 10.3390/ijms232315088.
Luo, Z., Chang, K.C., Wu, S., Sun, C., Xia, X., Nahmou, M., Bian, M., Wen, R.R., Zhu, Y., Shah, S., Tanasa, B., Wernig, M., & Goldberg, J.L. (2022). Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo. Stem Cell Reports, 17(12), 2690-2703.Elsevier. doi: 10.1016/j.stemcr.2022.10.011.
Noro, T., Shah, S.H., Yin, Y., Kawaguchi, R., Yokota, S., Chang, K.C., Madaan, A., Sun, C., Coppola, G., Geschwind, D., Benowitz, L.I., & Goldberg, J.L. (2022). Elk-1 regulates retinal ganglion cell axon regeneration after injury. Sci Rep, 12(1), 17446.Springer Nature. doi: 10.1038/s41598-022-21767-3.
Chang, K.C., Bian, M., Xia, X., Madaan, A., Sun, C., Wang, Q., Li, L., Nahmou, M., Noro, T., Yokota, S., Galvao, J., Kreymerman, A., Tanasa, B., Hu, Y., & Goldberg, J.L. (2021). Posttranslational Modification of Sox11 Regulates RGC Survival and Axon Regeneration. eNeuro, 8(1), eneuro.0358-eneu20.2020.Society for Neuroscience. doi: 10.1523/ENEURO.0358-20.2020.
Chen, Y.C., Wang, T.Y., Huang, Y.K., Chang, K.C., Chen, M.H., Liu, C.C., Liu, K.L., Yang, Y.H., Yen, D.H.T., & Fan, J.S. (2021). Effects of Sodium Silicate Complex against Hemorrhagic Activities Induced by Protobothrops mucrosquamatus Venom. Toxins (Basel), 13(1), 59.MDPI. doi: 10.3390/toxins13010059.
Ning, K., Song, E., Sendayen, B.E., Prosseda, P.P., Chang, K.C., Ghaffarieh, A., Alvarado, J.A., Wang, B., Haider, K.M., Berbari, N.F., Hu, Y., & Sun, Y. (2021). Defective INPP5E distribution in NPHP1-related Senior-Loken syndrome. Mol Genet Genomic Med, 9(1), e1566.Wiley. doi: 10.1002/mgg3.1566.
Pan, Y., Hysinger, J.D., Barron, T., Schindler, N.F., Cobb, O., Guo, X., Yalçın, B., Anastasaki, C., Mulinyawe, S.B., Ponnuswami, A., Scheaffer, S., Ma, Y., Chang, K.C., Xia, X., Toonen, J.A., Lennon, J.J., Gibson, E.M., Huguenard, J.R., Liau, L.M., Goldberg, J.L., Monje, M., & Gutmann, D.H. (2021). NF1 mutation drives neuronal activity-dependent initiation of optic glioma. Nature, 594(7862), 277-282.Springer Nature. doi: 10.1038/s41586-021-03580-6.
Chang, K.C., Huang, Y.K., Chen, Y.W., Chen, M.H., Tu, A.T., & Chen, Y.C. (2020). Venom Ophthalmia and Ocular Complications Caused by Snake Venom. Toxins (Basel), 12(9), 576.MDPI. doi: 10.3390/toxins12090576.
Mohammadinejad, R., Biagioni, A., Arunkumar, G., Shapiro, R., Chang, K.C., Sedeeq, M., Taiyab, A., Hashemabadi, M., Pardakhty, A., Mandegary, A., Thiery, J.P., Aref, A.R., & Azimi, I. (2020). EMT signaling: potential contribution of CRISPR/Cas gene editing. Cell Mol Life Sci, 77(14), 2701-2722.Springer Nature. doi: 10.1007/s00018-020-03449-3.
Wang, Q., Zhuang, P., Huang, H., Li, L., Liu, L., Webber, H.C., Dalal, R., Siew, L., Fligor, C.M., Chang, K.C., Nahmou, M., Kreymerman, A., Sun, Y., Meyer, J.S., Goldberg, J.L., & Hu, Y. (2020). Mouse γ-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells. J Neurosci, 40(20), 3896-3914.Society for Neuroscience. doi: 10.1523/JNEUROSCI.0102-20.2020.
Xia, X., Yu, C.Y., Bian, M., Sun, C.B., Tanasa, B., Chang, K.C., Bruffett, D.M., Thakur, H., Shah, S.H., Knasel, C., Cameron, E.G., Kapiloff, M.S., & Goldberg, J.L. (2020). MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury. In Badea, T.C. (Ed.). PLoS One, 15(12), e0242884.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0242884.
Zhang, X., Tenerelli, K., Wu, S., Xia, X., Yokota, S., Sun, C., Galvao, J., Venugopalan, P., Li, C., Madaan, A., Goldberg, J.L., & Chang, K.C. (2020). Cell transplantation of retinal ganglion cells derived from hESCs. Restor Neurol Neurosci, 38(2), 131-140.SAGE Publications. doi: 10.3233/RNN-190941.
Chang, K.C., Shieh, B., & Petrash, J.M. (2019). Role of aldose reductase in diabetes-induced retinal microglia activation. Chem Biol Interact, 302, 46-52.Elsevier. doi: 10.1016/j.cbi.2019.01.020.
Chang, K.C., Sun, C., Cameron, E.G., Madaan, A., Wu, S., Xia, X., Zhang, X., Tenerelli, K., Nahmou, M., Knasel, C.M., Russano, K.R., Hertz, J., & Goldberg, J.L. (2019). Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification. Curr Biol, 29(12), 1963-1975.e5.Elsevier. doi: 10.1016/j.cub.2019.05.011.
Kreymerman, A., Buickians, D.N., Nahmou, M.M., Tran, T., Galvao, J., Wang, Y., Sun, N., Bazik, L., Huynh, S.K., Cho, I.J., Boczek, T., Chang, K.C., Kunzevitzky, N.J., & Goldberg, J.L. (2019). MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses. Sci Rep, 9(1), 10669.Springer Nature. doi: 10.1038/s41598-019-46956-5.
Xia, X., Atkins, M., Dalal, R., Kuzmenko, O., Chang, K.C., Sun, C.B., Benatti, C.A., Rak, D.J., Nahmou, M., Kunzevitzky, N.J., & Goldberg, J.L. (2019). Magnetic Human Corneal Endothelial Cell Transplant: Delivery, Retention, and Short-Term Efficacy. Invest Ophthalmol Vis Sci, 60(7), 2438-2448.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.18-26001.
Chang, K.C., & Petrash, J.M. (2018). Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease. Adv Exp Med Biol, 1032(1032), 173-202.Springer Nature. doi: 10.1007/978-3-319-98788-0_13.
Wu, S., Chang, K.C., & Goldberg, J.L. (2018). Retinal Cell Fate Specification. Trends Neurosci, 41(4), 165-167.Elsevier. doi: 10.1016/j.tins.2018.02.002.
Wu, S., Chang, K.C., Nahmou, M., & Goldberg, J.L. (2018). Induced Pluripotent Stem Cells Promote Retinal Ganglion Cell Survival After Transplant. Invest Ophthalmol Vis Sci, 59(3), 1571-1576.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.17-23648.
Chang, K.C., & Hertz, J. (2017). SoxC transcription factors in retinal development and regeneration. Neural Regen Res, 12(7), 1048-1051.Wolters Kluwer. doi: 10.4103/1673-5374.211178.
Chang, K.C., Hertz, J., Zhang, X., Jin, X.L., Shaw, P., Derosa, B.A., Li, J.Y., Venugopalan, P., Valenzuela, D.A., Patel, R.D., Russano, K.R., Alshamekh, S.A., Sun, C., Tenerelli, K., Li, C., Velmeshev, D., Cheng, Y., Boyce, T.M., Dreyfuss, A., Uddin, M.S., Muller, K.J., Dykxhoorn, D.M., & Goldberg, J.L. (2017). Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development. J Neurosci, 37(19), 4967-4981.Society for Neuroscience. doi: 10.1523/JNEUROSCI.3430-13.2017.
Chang, K.C., Shieh, B., & Petrash, J.M. (2017). Influence of aldose reductase on epithelial-to-mesenchymal transition signaling in lens epithelial cells. Chem Biol Interact, 276, 149-154.Elsevier. doi: 10.1016/j.cbi.2017.01.017.
Chang, K.C., Li, L., Sanborn, T.M., Shieh, B., Lenhart, P., Ammar, D., LaBarbera, D.V., & Petrash, J.M. (2016). Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract. J Nat Prod, 79(5), 1439-1444.American Chemical Society (ACS). doi: 10.1021/acs.jnatprod.6b00185.
Chang, K.C., Shieh, B., & Petrash, J.M. (2016). Aldose reductase mediates retinal microglia activation. Biochem Biophys Res Commun, 473(2), 565-571.Elsevier. doi: 10.1016/j.bbrc.2016.03.122.
Chang, K.C., & Petrash, J.M. (2015). Aldose Reductase Mediates Transforming Growth Factor β2 (TGF-β2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells. Invest Ophthalmol Vis Sci, 56(8), 4198-4210.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.15-16557.
Chang, K.C., Snow, A., LaBarbera, D.V., & Petrash, J.M. (2015). Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells. Chem Biol Interact, 234, 254-260.Elsevier. doi: 10.1016/j.cbi.2014.10.007.
Snow, A., Shieh, B., Chang, K.C., Pal, A., Lenhart, P., Ammar, D., Ruzycki, P., Palla, S., Reddy, G.B., & Petrash, J.M. (2015). Aldose reductase expression as a risk factor for cataract. Chem Biol Interact, 234, 247-253.Elsevier. doi: 10.1016/j.cbi.2014.12.017.
Chang, K.C., Ponder, J., Labarbera, D.V., & Petrash, J.M. (2014). Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia. Invest Ophthalmol Vis Sci, 55(5), 2853-2861.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.13-13487.
Li, L., Chang, K.C., Zhou, Y., Shieh, B., Ponder, J., Abraham, A.D., Ali, H., Snow, A., Petrash, J.M., & LaBarbera, D.V. (2014). Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem, 57(1), 71-77.American Chemical Society (ACS). doi: 10.1021/jm401311d.
Chang, K.C., Laffin, B., Ponder, J., Enzsöly, A., Németh, J., LaBarbera, D.V., & Petrash, J.M. (2013). Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues. Chem Biol Interact, 202(1-3), 283-287.Elsevier. doi: 10.1016/j.cbi.2012.12.001.
Wu, M.H., Tsai, Y.T., Hua, K.T., Chang, K.C., Kuo, M.L., & Lin, M.T. (2012). Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. J Nutr Biochem, 23(11), 1434-1439.Elsevier. doi: 10.1016/j.jnutbio.2011.09.004.
Ho, P.C., Chang, K.C., Chuang, Y.S., & Wei, L.N. (2011). Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production. FASEB J, 25(5), 1758-1766.Wiley. doi: 10.1096/fj.10-179267.
Lai, C.W., Chen, K.Y., Hung, C.S., Kuo, S.W., Chang, Y.J., Lin, M.T., Chang, K.C., & Wu, M.H. (2011). Serum vascular endothelial growth factor-D levels correlate with cervical lymph node metastases in papillary thyroid carcinoma. Growth Factors, 29(2-3), 57-62.Taylor & Francis. doi: 10.3109/08977194.2011.557373.
Lu, P.H., Kuo, T.C., Chang, K.C., Chang, C.H., & Chu, C.Y. (2011). Gefitinib-induced epidermal growth factor receptor-independent keratinocyte apoptosis is mediated by the JNK activation pathway. Br J Dermatol, 164(1), 38-46.Oxford University Press (OUP). doi: 10.1111/j.1365-2133.2010.10038.x.
Chang, K.C., Lo, C.W., Fan, T.C., Chang, M.D.T., Shu, C.W., Chang, C.H., Chung, C.T., Fang, S.L., Chao, C.C., Tsai, J.J., & Lai, Y.K. (2010). TNF-alpha mediates eosinophil cationic protein-induced apoptosis in BEAS-2B cells. BMC Cell Biol, 11(1), 6.Springer Nature. doi: 10.1186/1471-2121-11-6.
Lo, C.W., Chang, Y.S., Chao, C.C., Chang, M.D.T., Chang, K.C., & Lai, Y.K. (2009). Control mechanisms of differential translation of Hsp90 isoforms in 9L rat gliosarcoma cells. J Cell Biochem, 107(3), 418-427.Wiley. doi: 10.1002/jcb.22138.
Chao, C.C., Sun, F.C., Wang, C.H., Lo, C.W., Chang, Y.S., Chang, K.C., Chang, M.D.T., & Lai, Y.K. (2008). Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells. J Cell Biochem, 104(4), 1286-1296.Wiley. doi: 10.1002/jcb.21705.