Justin Weinbaum

Research Assistant Professor
Assistant Professor
Vascular Bioengineering Laboratory Vascular ECM Dynamics Laboratory Bioengineering Department


Justin Weinbaum received his B.S. in Molecular Biology & Biophysics from Yale University in 2000. Under the mentorship of Dr. Robert Mecham at Washington University in St. Louis, and funded by a National Science Foundation Graduate Research Fellowship, he classified the elastic fiber component MAGP-1 as a new member of the matricellular protein family. Dr. Weinbaum received his Ph.D. in 2007 and joined Dr. Robert Tranquillo at the University of Minnesota. A NIH/NHLBI Ruth L. Kirschstein National Research Service Awardee, Dr. Weinbaum contributed key biological insight to the lab's projects in artery, valve, and heart patch tissue engineering. As an independent scientist, Dr. Weinbaum aims to understand how the native extracellular matrix directs cellular behavior and to develop new treatments for degenerative disease.


(2010) Midwest Affiliate Postdoctoral Fellowship, American Heart Association (declined).

(2010 - 2013) Ruth L. Kirschstein National Research Service Award, NIH/NHLBI.

(2009) American Society for Cell Biology Postdoctoral Travel Award.

(2003 - 2006) Graduate Research Fellowship, National Science Foundation.

(2003 - 2005) Lucille P. Markey Fellowship in Human Pathobiology.

(1998) Chester Summer Scholar.

Ph.D., Molecular Cell Biology, Washington University in St. Louis, 2001 - 2007

B.S., Molecular Biophysics and Biochemistry, Yale University, 1996 - 2000

Cunnane, E.M., Davis, N.F., Cunnane, C.V., Lorentz, K.L., Ryan, A.J., Hess, J., Weinbaum, J.S., Walsh, M.T., O'Brien, F.J., & Vorp, D.A. (2021). Mechanical, compositional and morphological characterisation of the human male urethra for the development of a biomimetic tissue engineered urethral scaffold. BIOMATERIALS, 269, 120651.Elsevier BV. doi: 10.1016/j.biomaterials.2021.120651.

Cunnane, E.M., Ramaswamy, A.K., Lorentz, K.L., Vorp, D.A., & Weinbaum, J.S. (2021). Extracellular Vesicles Derived from Primary Adipose Stromal Cells Induce Elastin and Collagen Deposition by Smooth Muscle Cells within 3D Fibrin Gel Culture. BIOENGINEERING-BASEL, 8(5), 51.MDPI AG. doi: 10.3390/bioengineering8050051.

Lorentz, K.L., Gupta, P., Shehabeldin, M.S., Cunnane, E.M., Ramaswamy, A.K., Verdelis, K., Dileo, M.V., Little, S.R., Weinbaum, J.S., Sfeir, C.S., Mandal, B.B., & Vorp, D.A. (2021). CCL2 loaded microparticles promote acute patency in silk-based vascular grafts implanted in rat aortae. ACTA BIOMATERIALIA, 135, 126-138.Elsevier BV. doi: 10.1016/j.actbio.2021.08.049.

Cunnane, E.M., Lorentz, K.L., Ramaswamy, A.K., Gupta, P., Mandal, B.B., O'Brien, F.J., Weinbaum, J.S., & Vorp, D.A. (2020). Extracellular Vesicles Enhance the Remodeling of Cell-Free Silk Vascular Scaffolds in Rat Aortae. ACS APPLIED MATERIALS & INTERFACES, 12(24), 26955-26965.American Chemical Society (ACS). doi: 10.1021/acsami.0c06609.

Cunnane, E.M., Lorentz, K.L., Soletti, L., Ramaswamy, A.K., Chung, T.K., Haskett, D.G., Luketich, S.K., Tzeng, E., D'Amore, A., Wagner, W.R., Weinbaum, J.S., & Vorp, D.A. (2020). Development of a Semi-Automated, Bulk Seeding Device for Large Animal Model Implantation of Tissue Engineered Vascular Grafts. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 8, 597847.Frontiers Media SA. doi: 10.3389/fbioe.2020.597847.

Gupta, P., Lorentz, K.L., Haskett, D.G., Cunnane, E.M., Ramaswamy, A.K., Weinbaum, J.S., Vorp, D.A., & Mandal, B.B. (2020). Bioresorbable silk grafts for small diameter vascular tissue engineering applications: In vitro and in vivo functional analysis. ACTA BIOMATERIALIA, 105, 146-158.Elsevier BV. doi: 10.1016/j.actbio.2020.01.020.

Ramaswamy, A.K., Sides, R.E., Cunnane, E.M., Lorentz, K.L., Reines, L.M., Vorp, D.A., & Weinbaum, J.S. (2019). Adipose-derived stromal cell secreted factors induce the elastogenesis cascade within 3D aortic smooth muscle cell constructs. Matrix Biol Plus, 4, 100014.Elsevier BV. doi: 10.1016/j.mbplus.2019.100014.

Ramaswamy, A.K., Vorp, D.A., & Weinbaum, J.S. (2019). Functional Vascular Tissue Engineering Inspired by Matricellular Proteins. FRONTIERS IN CARDIOVASCULAR MEDICINE, 6, 74.Frontiers Media SA. doi: 10.3389/fcvm.2019.00074.

Cunnane, E.M., Weinbaum, J.S., O'Brien, F.J., & Vorp, D.A. (2018). Future Perspectives on the Role of Stem Cells and Extracellular Vesicles in Vascular Tissue Regeneration. FRONTIERS IN CARDIOVASCULAR MEDICINE, 5, 86.Frontiers Media SA. doi: 10.3389/fcvm.2018.00086.

Haskett, D.G., Saleh, K.S., Lorentz, K.L., Josowitz, A.D., Luketich, S.K., Weinbaum, J.S., Kokai, L.E., D'Amore, A., Marra, K.G., Rubin, J.P., Wagner, W.R., & Vorp, D.A. (2018). An exploratory study on the preparation and evaluation of a "same-day'' adipose stem cell-based tissue-engineered vascular graft. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 156(5), 1814-+.Elsevier BV. doi: 10.1016/j.jtcvs.2018.05.120.

Cheheltani, R., Pichamuthu, J.E., Rao, J., Weinbaum, J.S., Kiani, M.F., Vorp, D.A., & Pleshko, N. (2017). Fourier Transform Infrared Spectroscopic Imaging-Derived Collagen Content and Maturity Correlates with Stress in the Aortic Wall of Abdominal Aortic Aneurysm Patients. CARDIOVASCULAR ENGINEERING AND TECHNOLOGY, 8(1), 70-80.Springer Science and Business Media LLC. doi: 10.1007/s13239-016-0289-3.

Krawiec, J.T., Liao, H.T., Kwan, L.L., D'Amore, A., Weinbaum, J.S., Rubin, J.P., Wagner, W.R., & Vorp, D.A. (2017). Evaluation of the stromal vascular fraction of adipose tissue as the basis for a stem cell-based tissue-engineered vascular graft. JOURNAL OF VASCULAR SURGERY, 66(3), 883-+.Elsevier BV. doi: 10.1016/j.jvs.2016.09.034.

Krawiec, J.T., Weinbaum, J.S., Liao, H.T., Ramaswamy, A.K., Pezzone, D.J., Josowitz, A.D., D'Amore, A., Rubin, J.P., Wagner, W.R., & Vorp, D.A. (2016). In Vivo Functional Evaluation of Tissue-Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High Cardiovascular Risk Populations. TISSUE ENGINEERING PART A, 22(9-10), 765-775.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2015.0379.

Krawiec, J.T., Weinbaum, J.S., St Croix, C.M., Phillippi, J.A., Watkins, S.C., Rubin, J.P., & Vorp, D.A. (2015). A Cautionary Tale for Autologous Vascular Tissue Engineering: Impact of Human Demographics on the Ability of Adipose-Derived Mesenchymal Stem Cells to Recruit and Differentiate into Smooth Muscle Cells. TISSUE ENGINEERING PART A, 21(3-4), 426-437.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2014.0208.

Rao, J., Brown, B.N., Weinbaum, J.S., Ofstun, E.L., Makaroun, M.S., Humphrey, J.D., & Vorp, D.A. (2015). Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm. JOURNAL OF VASCULAR SURGERY, 62(3), 585-593.Elsevier BV. doi: 10.1016/j.jvs.2014.11.086.

Blose, K.J., Ennis, T.L., Arif, B., Weinbaum, J.S., Curci, J.A., & Vorp, D.A. (2014). Periadventitial adipose-derived stem cell treatment halts elastase-induced abdominal aortic aneurysm progression. REGENERATIVE MEDICINE, 9(6), 733-741.Future Medicine Ltd. doi: 10.2217/RME.14.61.

Blose, K.J., Krawiec, J.T., Weinbaum, J.S., & Vorp, D.A. (2014). Bioreactors for Tissue Engineering Purposes. In Regenerative Medicine Applications in Organ Transplantation. (pp. 177-185).Elsevier. doi: 10.1016/b978-0-12-398523-1.00013-6.

Krawiec, J.T., Bruce, K., Josowitz, A., Kokai, L., D'Amore, A., Weinbaum, J., Wagner, W., Rubin, P., & Vorp, D. (2014). Evaluating cells from liposuction aspirates for vascular tissue engineering. ANGIOGENESIS, 17, (p. 306).Hyannis, MA.

Blose, K.J., Krawiec, J.T., Weinbaum, J.S., & Vorp, D.A. (2013). Bioreactors for Tissue Engineering Purposes; Chapter 15. (pp. 201-210).Academic Press.

Weinbaum, J.S., Schmidt, J.B., & Tranquillo, R.T. (2013). Combating Adaptation to Cyclic Stretching by Prolonging Activation of Extracellular Signal-Regulated Kinase. CELLULAR AND MOLECULAR BIOENGINEERING, 6(3), 279-286.Springer Science and Business Media LLC. doi: 10.1007/s12195-013-0289-4.

Ahmann, K.A., Weinbaum, J.S., Johnson, S.L., & Tranquillo, R.T. (2010). Fibrin Degradation Enhances Vascular Smooth Muscle Cell Proliferation and Matrix Deposition in Fibrin-Based Tissue Constructs Fabricated In Vitro. TISSUE ENGINEERING PART A, 16(10), 3261-3270.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2009.0708.

Craft, C.S., Zou, W., Watkins, M., Grimston, S., Brodt, M.D., Broekelmann, T.J., Weinbaum, J.S., Teitelbaum, S.L., Pierce, R.A., Civitelli, R., Silva, M.J., & Mecham, R.P. (2010). Microfibril-associated Glycoprotein-1, an Extracellular Matrix Regulator of Bone Remodeling. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(31), 23858-23867.Elsevier BV. doi: 10.1074/jbc.M110.113019.

Weinbaum, J.S., Qi, J., & Tranquillo, R.T. (2010). Monitoring Collagen Transcription by Vascular Smooth Muscle Cells in Fibrin-Based Tissue Constructs. TISSUE ENGINEERING PART C-METHODS, 16(3), 459-467.Mary Ann Liebert Inc. doi: 10.1089/ten.tec.2009.0112.

Weinbaum, J.S., Tranquillo, R.T., & Mecham, R.P. (2010). The Matrix-Binding Domain of Microfibril-Associated Glycoprotein-1 Targets Active Connective Tissue Growth Factor to a Fibroblast-Produced Extracellular Matrix. MACROMOLECULAR BIOSCIENCE, 10(11), 1338-1344.Wiley. doi: 10.1002/mabi.201000121.

III, B.L.D., Meyers, J.D., Weinbaum, J.S., Shvelidze, Y.A., & Tranquillo, R.T. (2009). Cell-Induced Alignment Augments Twitch Force in Fibrin Gel-Based Engineered Myocardium via Gap Junction Modification. TISSUE ENGINEERING PART A, 15(10), 3099-3108.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2008.0502.

Syedain, Z.H., Weinberg, J.S., & Tranquillo, R.T. (2008). Cyclic distension of fibrin-based tissue constructs: Evidence of adaptation during growth of engineered connective tissue. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(18), 6537-6542.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0711217105.

Weinbaum, J.S., Broekelmann, T.J., Pierce, R.A., Werneck, C.C., Segade, F., Craft, C.S., Knutsen, R.H., & Mecham, R.P. (2008). Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(37), 25533-25543.Elsevier BV. doi: 10.1074/jbc.M709962200.

Werneck, C.C., Vicente, C.P., Weinberg, J.S., Shifren, A., Pierce, R.A., Broekelmann, T.J., Tollefsen, D.M., & Mecham, R.P. (2008). Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. BLOOD, 111(8), 4137-4144.American Society of Hematology. doi: 10.1182/blood-2007-07-101733.

Estacion, M., Weinberg, J.S., Sinkins, W.G., & Schilling, W.P. (2003). Blockade of maitotoxin-induced endothelial cell lysis by glycine and L-alanine. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 284(4), C1006-C1020.American Physiological Society. doi: 10.1152/ajpcell.00258.2002.

Deverman, B.E., Cook, B.L., Manson, S.R., Niederhoff, R.A., Langer, E.M., Rosova, I., Kulans, L.A., Fu, X.Y., Weinberg, J.S., Heinecke, J.W., Roth, K.A., & Weintraub, S.J. (2002). Bcl-X-L deamidation is a critical switch in the regulation of the response to DNA damage. CELL, 111(1), 51-62.Elsevier BV. doi: 10.1016/S0092-8674(02)00972-8.

Wankhade, S., Yu, Y.H., Weinberg, J., Tainsky, M.A., & Kannan, P. (2000). Characterization of the activation domains of AP-2 family transcription factors. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(38), 29701-29708.Elsevier BV. doi: 10.1074/jbc.M000931200.

Blose, K.J., Pichamuthu, J.E., Weinbaum, J.S., & Vorp, D.A. (2016). Design and validation of a vacuum assisted anchorage for the uniaxial tensile testing of soft materials. Annual Fall Meeting of the Biomedical Engineering Society.United States. doi: 10.1080/1539445X.2016.1141787.

Weinbaum, J.S. (2015). Methods for Monitoring New Elastin Formation During Elastogenic Therapy. In TISSUE ENGINEERING PART A, 21, (pp. S375-S376).

Weinbaum, J., Schmidt, J., & Tranquillo, R. (2012). Combating adaptation to stretch conditioning through prolonged activation of extracellular signal-regulated kinase. American Society for Matrix Biology.San Diego, CA.

Pierce, R.A., Craft, C.S., Weinbaum, J.S., Broekelmann, T., & Mecham, R.P. (2009). Microfibril-associated glycoprotein-1 binds multiple active TGF-beta family members, affecting homeostasis in multiple organ systems. In FASEB JOURNAL, 23.

Research interests

extracellular matrix
extracellular matrix proteins
muscle, smooth, vascular
tissue engineering