PhD, Cleveland State University
Crum, R.J., Capella-Monsonís, H., Chang, J., Dewey, M.J., Kolich, B.D., Hall, K.T., El-Mossier, S.O., Nascari, D.G., Hussey, G.S., & Badylak, S.F. (2023). Biocompatibility and biodistribution of matrix-bound nanovesicles in vitro and in vivo. Acta Biomater, 155, 113-122.Elsevier. doi: 10.1016/j.actbio.2022.11.026.
Crum, R.J., Huckestien, B.R., Dwyer, G., Mathews, L., Nascari, D.G., Hussey, G.S., Turnquist, H.R., Alcorn, J.F., & Badylak, S.F. (2023). Mitigation of influenza-mediated inflammation by immunomodulatory matrix-bound nanovesicles. Sci Adv, 9(20), eadf9016.American Association for the Advancement of Science (AAAS). doi: 10.1126/sciadv.adf9016.
Behre, A., Tashman, J.W., Dikyol, C., Shiwarski, D.J., Crum, R.J., Johnson, S.A., Kommeri, R., Hussey, G.S., Badylak, S.F., & Feinberg, A.W. (2022). 3D Bioprinted Patient-Specific Extracellular Matrix Scaffolds for Soft Tissue Defects. Adv Healthc Mater, 11(24), e2200866.Wiley. doi: 10.1002/adhm.202200866.
Cramer, M., Pineda Molina, C., Hussey, G., Turnquist, H.R., & Badylak, S.F. (2022). Transcriptomic Regulation of Macrophages by Matrix-Bound Nanovesicle-Associated Interleukin-33. Tissue Eng Part A, 28(19-20), 867-878.Mary Ann Liebert. doi: 10.1089/ten.TEA.2022.0006.
Crum, R.J., Capella-Monsonis, H., Badylak, S.F., & Hussey, G.S. (2022). Extracellular Vesicles for Regenerative Medicine Applications. APPLIED SCIENCES-BASEL, 12(15), 7472.MDPI. doi: 10.3390/app12157472.
Crum, R.J., Hall, K., Molina, C.P., Hussey, G.S., Graham, E., Li, H., & Badylak, S.F. (2022). Immunomodulatory matrix-bound nanovesicles mitigate acute and chronic pristane-induced rheumatoid arthritis. NPJ Regen Med, 7(1), 13.Springer Nature. doi: 10.1038/s41536-022-00208-9.
Murdock, M.H., Hussey, G.S., Chang, J.T., Hill, R.C., Nascari, D.G., Rao, A.V., Hansen, K.C., Foley, L.M., Hitchens, T.K., Amankulor, N.M., & Badylak, S.F. (2022). A liquid fraction of extracellular matrix inhibits glioma cell viability in vitro and in vivo. Oncotarget, 13(1), 426-438.Impact Journals. doi: 10.18632/oncotarget.28203.
Turner, N.J., Quijano, L.M., Hussey, G.S., Jiang, P., & Badylak, S.F. (2022). Matrix Bound Nanovesicles Have Tissue-Specific Characteristics That Suggest a Regulatory Role. Tissue Eng Part A, 28(21-22), 879-892.Mary Ann Liebert. doi: 10.1089/ten.TEA.2022.0091.
Pineda Molina, C., Hussey, G.S., Liu, A., Eriksson, J., D'Angelo, W.A., & Badylak, S.F. (2021). Role of 4-hydroxybutyrate in increased resistance to surgical site infections associated with surgical meshes. Biomaterials, 267, 120493.Elsevier. doi: 10.1016/j.biomaterials.2020.120493.
Hussey, G.S., Nascari, D.G., Saldin, L.T., Kolich, B., Lee, Y.C., Crum, R.J., El-Mossier, S.O., D'Angelo, W., Dziki, J.L., & Badylak, S.F. (2020). Ultrasonic cavitation to prepare ECM hydrogels. Acta Biomater, 108, 77-86.Elsevier. doi: 10.1016/j.actbio.2020.03.036.
Hussey, G.S., Pineda Molina, C., Cramer, M.C., Tyurina, Y.Y., Tyurin, V.A., Lee, Y.C., El-Mossier, S.O., Murdock, M.H., Timashev, P.S., Kagan, V.E., & Badylak, S.F. (2020). Lipidomics and RNA sequencing reveal a novel subpopulation of nanovesicle within extracellular matrix biomaterials. Sci Adv, 6(12), eaay4361.American Association for the Advancement of Science (AAAS). doi: 10.1126/sciadv.aay4361.
Li, T., Zhang, Z., Bartolacci, J.G., Dwyer, G.K., Liu, Q., Mathews, L.R., Velayutham, M., Roessing, A.S., Lee, Y.C., Dai, H., Shiva, S., Oberbarnscheidt, M.H., Dziki, J.L., Mullet, S.J., Wendell, S.G., Wilkinson, J.D., Webber, S.A., Wood-Trageser, M., Watkins, S.C., Demetris, A.J., Hussey, G.S., Badylak, S.F., & Turnquist, H.R. (2020). Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. J Clin Invest, 130(10), 5397-5412.American Society for Clinical Investigation. doi: 10.1172/JCI133008.
Hussey, G.S., Dziki, J.L., Lee, Y.C., Bartolacci, J.G., Behun, M., Turnquist, H.R., & Badylak, S.F. (2019). Matrix bound nanovesicle-associated IL-33 activates a pro-remodeling macrophage phenotype via a non-canonical, ST2-independent pathway. J Immunol Regen Med, 3, 26-35.Elsevier. doi: 10.1016/j.regen.2019.01.001.
Murdock, M.H., Chang, J.T., Luketich, S.K., Pedersen, D., Hussey, G.S., D'Amore, A., & Badylak, S.F. (2019). Cytocompatibility and mechanical properties of surgical sealants for cardiovascular applications. J Thorac Cardiovasc Surg, 157(1), 176-183.Elsevier. doi: 10.1016/j.jtcvs.2018.08.043.
Pineda Molina, C., Hussey, G.S., Eriksson, J., Shulock, M.A., Cárdenas Bonilla, L.L., Giglio, R.M., Gandhi, R.M., Sicari, B.M., Wang, D., Londono, R., Faulk, D.M., Turner, N.J., & Badylak, S.F. (2019). 4-Hydroxybutyrate Promotes Endogenous Antimicrobial Peptide Expression in Macrophages. Tissue Eng Part A, 25(9-10), 693-706.Mary Ann Liebert. doi: 10.1089/ten.TEA.2018.0377.
Saldin, L.T., Patel, S., Zhang, L., Huleihel, L., Hussey, G.S., Nascari, D.G., Quijano, L.M., Li, X., Raghu, D., Bajwa, A.K., Smith, N.G., Chung, C.C., Omstead, A.N., Kosovec, J.E., Jobe, B.A., Turner, N.J., Zaidi, A.H., & Badylak, S.F. (2019). Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype. Tissue Eng Part A, 25(5-6), 487-498.Mary Ann Liebert. doi: 10.1089/ten.TEA.2018.0105.
van der Merwe, Y., Faust, A.E., Sakalli, E.T., Westrick, C.C., Hussey, G., Chan, K.C., Conner, I.P., Fu, V.L.N., Badylak, S.F., & Steketee, M.B. (2019). Author Correction: Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function. Sci Rep, 9(1), 15799.Springer Nature. doi: 10.1038/s41598-019-50829-2.
van der Merwe, Y., Faust, A.E., Sakalli, E.T., Westrick, C.C., Hussey, G., Chan, K.C., Conner, I.P., Fu, V.L.N., Badylak, S.F., & Steketee, M.B. (2019). Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function. Sci Rep, 9(1), 3482.Springer Nature. doi: 10.1038/s41598-019-39861-4.
Dziki, J.L., Hussey, G., & Badylak, S.F. (2018). Alarmins of the extracellular space. Semin Immunol, 38(C), 33-39.Elsevier. doi: 10.1016/j.smim.2018.08.004.
Hussey, G.S., Cramer, M.C., & Badylak, S.F. (2018). Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue. Cell Mol Gastroenterol Hepatol, 5(1), 1-13.Elsevier. doi: 10.1016/j.jcmgh.2017.09.004.
Hussey, G.S., Dziki, J.L., & Badylak, S.F. (2018). Extracellular matrix-based materials for regenerative medicine. NATURE REVIEWS MATERIALS, 3(7), 159-173.Springer Nature. doi: 10.1038/s41578-018-0023-x.
Ansa-Addo, E.A., Zhang, Y., Yang, Y., Hussey, G.S., Howley, B.V., Salem, M., Riesenberg, B., Sun, S., Rockey, D.C., Karvar, S., Howe, P.H., Liu, B., & Li, Z. (2017). Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. J Clin Invest, 127(4), 1321-1337.American Society for Clinical Investigation. doi: 10.1172/JCI89281.
Faust, A., Kandakatla, A., van der Merwe, Y., Ren, T., Huleihel, L., Hussey, G., Naranjo, J.D., Johnson, S., Badylak, S., & Steketee, M. (2017). Urinary bladder extracellular matrix hydrogels and matrix-bound vesicles differentially regulate central nervous system neuron viability and axon growth and branching. J Biomater Appl, 31(9), 1277-1295.SAGE Publications. doi: 10.1177/0885328217698062.
Hussey, G.S., Keane, T.J., & Badylak, S.F. (2017). The extracellular matrix of the gastrointestinal tract: a regenerative medicine platform. Nat Rev Gastroenterol Hepatol, 14(9), 540-552.Springer Nature. doi: 10.1038/nrgastro.2017.76.
Gupta, S., Hau, A.M., Al-Ahmadie, H.A., Harwalkar, J., Shoskes, A.C., Elson, P., Beach, J.R., Hussey, G.S., Schiemann, W.P., Egelhoff, T.T., Howe, P.H., & Hansel, D.E. (2016). Transforming Growth Factor-β Is an Upstream Regulator of Mammalian Target of Rapamycin Complex 2-Dependent Bladder Cancer Cell Migration and Invasion. Am J Pathol, 186(5), 1351-1360.Elsevier. doi: 10.1016/j.ajpath.2016.01.008.
Howley, B.V., Hussey, G.S., Link, L.A., & Howe, P.H. (2016). Translational regulation of inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells. Oncogene, 35(13), 1725-1735.Springer Nature. doi: 10.1038/onc.2015.238.
Huleihel, L., Hussey, G.S., Naranjo, J.D., Zhang, L., Dziki, J.L., Turner, N.J., Stolz, D.B., & Badylak, S.F. (2016). Matrix-bound nanovesicles within ECM bioscaffolds. Sci Adv, 2(6), e1600502.American Association for the Advancement of Science (AAAS). doi: 10.1126/sciadv.1600502.
Link, L.A., Howley, B.V., Hussey, G.S., & Howe, P.H. (2016). PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. Mol Cancer Res, 14(7), 634-646.American Association for Cancer Research (AACR). doi: 10.1158/1541-7786.MCR-16-0018.
Loneker, A.E., Faulk, D.M., Hussey, G.S., D'Amore, A., & Badylak, S.F. (2016). Solubilized liver extracellular matrix maintains primary rat hepatocyte phenotype in-vitro. J Biomed Mater Res A, 104(7), 1846-1847.Wiley. doi: 10.1002/jbm.a.35778.
Loneker, A.E., Faulk, D.M., Hussey, G.S., D'Amore, A., & Badylak, S.F. (2016). Solubilized liver extracellular matrix maintains primary rat hepatocyte phenotype in-vitro. J Biomed Mater Res A, 104(4), 957-965.Wiley. doi: 10.1002/jbm.a.35636.
Hussey, G.S., Howley, B.V., & Howe, P.H. (2015). Post-transcriptional mapping reveals critical regulators of metastasis. Oncoscience, 2(10), 831-832.Impact Journals. doi: 10.18632/oncoscience.207.
Hussey, G.S., Link, L.A., Brown, A.S., Howley, B.V., Chaudhury, A., & Howe, P.H. (2012). Establishment of a TGFβ-induced post-transcriptional EMT gene signature. In Katz, E. (Ed.). PLoS One, 7(12), e52624.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0052624.
Beach, J.R., Hussey, G.S., Miller, T.E., Chaudhury, A., Patel, P., Monslow, J., Zheng, Q., Keri, R.A., Reizes, O., Bresnick, A.R., Howe, P.H., & Egelhoff, T.T. (2011). Myosin II isoform switching mediates invasiveness after TGF-β-induced epithelial-mesenchymal transition. Proc Natl Acad Sci U S A, 108(44), 17991-17996.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1106499108.
Chaudhury, A., Hussey, G.S., & Howe, P.H. (2011). 3'-UTR-mediated post-transcriptional regulation of cancer metastasis: beginning at the end. RNA Biol, 8(4), 595-599.Taylor & Francis. doi: 10.4161/rna.8.4.16018.
Chaudhury, A., Hussey, G.S., & Howe, P.H. (2011). 3′-UTR-mediated post-transcriptional regulation of cancer metastasis: Beginning at the end. RNA Biology, 8(4).
Hussey, G.S., Chaudhury, A., Dawson, A.E., Lindner, D.J., Knudsen, C.R., Wilce, M.C.J., Merrick, W.C., & Howe, P.H. (2011). Identification of an mRNP complex regulating tumorigenesis at the translational elongation step. Mol Cell, 41(4), 419-431.Elsevier. doi: 10.1016/j.molcel.2011.02.003.
Chaudhury, A., Hussey, G.S., Ray, P.S., Jin, G., Fox, P.L., & Howe, P.H. (2010). TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat Cell Biol, 12(3), 286-293.Springer Nature. doi: 10.1038/ncb2029.
Crum, R.J., Hall, K., Molina, C.P., Hussey, G.S., Graham, E., Li, H., & Badylak, S.F. (2022). Matrix Bound Nanovesicles As A Novel Extracellular Matrix Therapy For The Treatment Of Rheumatoid Arthritis. In TISSUE ENGINEERING PART A, 28, (pp. 6-7).
Hall, K.T., Fisher, S., Hussey, G.S., & Badylak, S.F. (2022). Therapeutic Potential Of Matrix Bound Nanovesicles In Rodent Model Of Ulcerative Colitis. In TISSUE ENGINEERING PART A, 28, (pp. 28-29).
Hussey, G.S., & Badylak, S.F. (2022). MATRIX BOUND NANOVESICLES: THE NEXT GENERATION OF ECM-BASED MATERIALS. In TISSUE ENGINEERING PART A, 28, (pp. S146-S147).
Hussey, G.S., & Badylak, S.F. (2022). DEVELOPMENT OF FABRICATION METHODS FOR LARGE-SCALE MANUFACTURING OF CLINICAL GRADE ECM HYDROGELS. In TISSUE ENGINEERING PART A, 28, (p. S152).
Li, J., Al Matour, B., Sato, T., Badylak, S.F., Hussey, G.S., Scott, M.J., & Arteel, G.E. (2022). THERAPEUTIC MATRIX-BOUND NANOVESICLES (MBV) PROTECT AGAINST EXPERIMENT ALCOHOL-ASSOCIATED LIVER DISEASE IN MICE. In HEPATOLOGY, 76, (pp. S983-S984).
Turner, N.J., Quijano, L.M., Hussey, G.S., Jiang, P., Badylak, S.F., Badylak, S.F. (2022). Compositional Analysis Confirms Matrix Bound Nanovesicles Have Tissue Specific Characteristics Suggesting A Regulatory Role In Homeostasis. In TISSUE ENGINEERING PART A, 28, (pp. 195-196).
Al Matour, B., Sato, T., Li, J., Merchant, M.L., Wilkey, D., Badylak, S.F., Hussey, G.S., Arteel, G.E., & Scott, M.J. (2021). EXPERIMENTAL ALCOHOL EXPOSURE ALTERS MATRIX-BOUND VESICLE CARGO AND MACROPHAGE ACTIVATION. In HEPATOLOGY, 74, (pp. 212A-213A).
Sato, T., Al Matour, B., Li, J., Merchant, M.L., Wilkey, D., Badylak, S.F., Hussey, G.S., Scott, M.J., & Arteel, G.E. (2021). EXPERIMENTAL FIBROSIS ALTERS MATRIX-BOUND VESICLES CARGO THAT DO NOT REVERT AFTER HISTOLOGIC RECOVERY. In HEPATOLOGY, 74, (pp. 813A-814A).
Zhang, Z., Liu, Q., Li, T., Hussey, G.S., Velayutham, M., Dziki, J.L., Mathews, L.R., Lee, Y.C., Dwyer, G.K., Dai, H., Roessing, A.S., Shiva, S., Oberbarnscheidt, M.H., Badylak, S.F., & Turnquist, H.R. (2019). Local IL-33 Regulates Heart Transplant Infiltrating Myeloid Cells Metabolism and Differentiation to Protect against Chronic Rejection. In AMERICAN JOURNAL OF TRANSPLANTATION, 19, (p. 526).
Hussey, G.S., & Badylak, S.F. (2017). Nanovesicles within ECM Bioscaffolds as Regulators of the Strength of Soft Tissue Repair. In TISSUE ENGINEERING PART A, 23, (p. S15).
Hussey, G.S., Dziki, J.L., Turnquist, H.R., & Badylak, S.F. (2017). Il-33 As a Key Signaling Molecule for the Therapeutic Effects of ECM Bioscaffolds for Cardiac Repair. In TISSUE ENGINEERING PART A, 23, (p. S29).
Molina, C.P., Hussey, G.S., Dziki, J.L., Eriksson, J., & Badylak, S.F. (2017). Antimicrobial Peptides with Biologic and Biosynthetic Scaffolds for Regenerative Medicine. In TISSUE ENGINEERING PART A, 23, (pp. S28-S29).
Torres, C.M., Reing, J.E., Molina, C.P., Hussey, G.S., & Badylak, S.F. (2017). Tissue-Specific Extracellular Matrix Hydrogel Promotes the Growth and Differentiation of Lgr5+Intestinal Stem Cells into Viable Enteroids. In JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 225(4), (p. S204).Wolters Kluwer. doi: 10.1016/j.jamcollsurg.2017.07.470.
Molina, C.P., Giglio, R.M., Hussey, G.S., Sicari, B.M., Gandhi, R.M., & Badylak, S.F. (2016). Expression of Antimicrobial Peptides by Macrophages Exposed to Solubilized Extracellular Matrix. In TISSUE ENGINEERING PART A, 22, (p. S98).