overview

Dr. Elia Beniash is an associate professor at the University of Pittsburgh School of Dental Medicine. His position is located in Oral Biology. Prior to arriving at Pitt in 2007, Dr. Beniash was a staff member at the Forsyth Institute in Boston, Mass. and an instructor at the Harvard University School of Dental Medicine. Dr. Beniash holds an MSc in Zoology and Biology from the St. Petersburg State University in Russia. His PhD in Structural Biology and Chemistry is from the Weizmann Institute of Science in Rehovot, Israel. Dr. Beniash's scientific interests include biomineralization, the structure/function relationships in supramolecular assemblies, bioinspired materials, and tissue engineering. One of the focuses of his lab is biogenic mineralized materials, such as those found in shells, bones, and teeth. His studies are concentrated on understanding basic strategies of mineralization in biological systems and applying these strategies to the design of new, nanostructured composite materials. As a result of his research, Dr. Beniash holds at least four patents and is the recipient of several awards including the Young Investigator Award from the 8th International Conference on the Chemistry and Biology of Mineralized Tissues and a New Investigator Award from the Enamel VII Symposium

about

(2013) President elect, Mineralized Tissues Group, International Association for Dental Research.

(2012) Chair of a symposium on Novel Bioinspired Approaches for Craniofacial Repair and Regeneration, AADR meeting, March 2012, Tampa, Fl.

(2012 - 2013) Vice-President Mineralized Tissues Group, International Association for Dental Research.

(2011) Chair of a session at the IADR meeting in San Diego,CA.

(2011) Research conducted under NSF Award #0951139 has been selected as a research highlight.

(2011) Journal of Structural Biology Top Cited Article Award, 2009-2011 for the article entitled "Transient amorphous calcium phosphate in forming enamel.".

(2008) Acta Biomaterialia Most Cited Author Award 2005-2008 for the paper entitled: Self-Assembled Peptide Amphiphile Matrices for Cell Entrapment.

(2005) New Investigator Award, Enamel VII Symposium, Brewster, MA, USA.

(2004) New Investigator Award, 8th International Conference on the Chemistry and Biology of Mineralized Tissues, Banff, Canada.

(1998) Young Investigator Award, 6th International Conference on the Chemistry and Biology of Mineralized Tissues, Vittel, France.

Ivanina, A.V., Jarrett, A., Bell, T., Rimkevicius, T., Beniash, E., & Sokolova, I.M. (2020). Effects of seawater salinity and pH on cellular metabolism and enzyme activities in biomineralizing tissues of marine bivalves. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 248, 110748.Elsevier BV. doi: 10.1016/j.cbpa.2020.110748.

Khalid, S., Yamazaki, H., Socorro, M., Monier, D., Beniash, E., & Napierala, D. (2020). Reactive oxygen species (ROS) generation as an underlying mechanism of inorganic phosphate (P-i)-induced mineralization of osteogenic cells. FREE RADICAL BIOLOGY AND MEDICINE, 153, 103-111.Elsevier BV. doi: 10.1016/j.freeradbiomed.2020.04.008.

Patel, A., Zaky, S.H., Schoedel, K., Li, H., Sant, V., Beniash, E., Sfeir, C., Stolz, D.B., & Sant, S. (2020). Design and evaluation of collagen-inspired mineral-hydrogel nanocomposites for bone regeneration. ACTA BIOMATERIALIA, 112, 262-273.Elsevier BV. doi: 10.1016/j.actbio.2020.05.034.

Shin, N.Y., Yamazaki, H., Beniash, E., Yang, X., Margolis, S.S., Pugach, M.K., Simmer, J.P., & Margolis, H.C. (2020). Amelogenin phosphorylation regulates tooth enamel formation by stabilizing a transient amorphous mineral precursor. JOURNAL OF BIOLOGICAL CHEMISTRY, 295(7), 1943-1959.Elsevier BV. doi: 10.1074/jbc.RA119.010506.

Socorro, M., Shinde, A., Yamazaki, H., Khalid, S., Monier, D., Beniash, E., & Napierala, D. (2020). Trps1 transcription factor represses phosphate-induced expression of SerpinB2 in osteogenic cells. BONE, 141, 115673.Elsevier BV. doi: 10.1016/j.bone.2020.115673.

Zaky, S.H., AlQahtani, Q., Chen, J., Patil, A., Taboas, J., Beniash, E., Jr, R.H., & Sfeir, C. (2020). Effect of the Periapical "Inflammatory Plug" on Dental Pulp Regeneration: A Histologic In Vivo Study. JOURNAL OF ENDODONTICS, 46(1), 51-56.Elsevier BV. doi: 10.1016/j.joen.2019.10.006.

Beniash, E., Stifler, C.A., Sun, C.Y., Jung, G.S., Qin, Z., Buehler, M.J., & Gilbert, P.U.P.A. (2019). The hidden structure of human enamel. NATURE COMMUNICATIONS, 10(1), 4383.Springer Science and Business Media LLC. doi: 10.1038/s41467-019-12185-7.

Chiba, R., Okubo, M., Yamamoto, R., Saito, M.M., Kobayashi, S., Beniash, E., & Yamakoshi, Y. (2019). Porcine keratin 75 in developing enamel. J Oral Biosci, 61(3), 163-172.Elsevier BV. doi: 10.1016/j.job.2019.06.002.

Hong, D., Zaky, S.H., Chong, R., Lukashova, L., Beniash, E., Verdelis, K., Witte, F., & Sfeir, C. (2019). Controlling magnesium corrosion and degradation-regulating mineralization using matrix GLA protein. ACTA BIOMATERIALIA, 98, 142-151.Elsevier BV. doi: 10.1016/j.actbio.2019.05.048.

Patil, A., Zaky, S.H., Chong, R., Verdelis, K., & Beniash, E. (2019). In vivo study of self-assembled alkylsilane coated degradable magnesium devices. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 107(2), 342-351.Wiley. doi: 10.1002/jbm.b.34126.

Yamazaki, H., Tran, B., Beniash, E., Kwak, S.Y., & Margolis, H.C. (2019). Proteolysis by MMP20 Prevents Aberrant Mineralization in Secretory Enamel. JOURNAL OF DENTAL RESEARCH, 98(4), 468-475.SAGE Publications. doi: 10.1177/0022034518823537.

Yang, X., & Beniash, E. (2019). Immunofluorescence Procedure for Developing Enamel Tissues. Methods Mol Biol, 1922, 191-196.Springer New York. doi: 10.1007/978-1-4939-9012-2_19.

Yang, X., Yamazaki, H., Yamakoshi, Y., Duverger, O., Morasso, M.I., & Beniash, E. (2019). Trafficking and secretion of keratin 75 by ameloblasts in vivo. JOURNAL OF BIOLOGICAL CHEMISTRY, 294(48), 18475-18487.Elsevier BV. doi: 10.1074/jbc.RA119.010037.

Alqahtani, Q., Zaky, S.H., Patil, A., Beniash, E., Ray, H., & Sfeir, C. (2018). Decellularized Swine Dental Pulp Tissue for Regenerative Root Canal Therapy. JOURNAL OF DENTAL RESEARCH, 97(13), 1460-1467.SAGE Publications. doi: 10.1177/0022034518785124.

Ivanina, A.V., Borah, B., Rimkevicius, T., Macrander, J., Piontkivska, H., Sokolova, I.M., & Beniash, E. (2018). The Role of the Vascular Endothelia Growth Factor (VEGF) Signaling in Biomineralization of the Oyster Crassostrea gigas. FRONTIERS IN MARINE SCIENCE, 5(AUG).Frontiers Media SA. doi: 10.3389/fmars.2018.00309.

Ivanina, A.V., Borah, B.M., Vogts, A., Malik, I., Wu, J., Chin, A.R., Almarza, A.J., Kumta, P., Piontkivska, H., Beniash, E., & Sokolova, I.M. (2018). Potential trade-offs between biomineralization and immunity revealed by shell properties and gene expression profiles of two closely related Crassostrea species. JOURNAL OF EXPERIMENTAL BIOLOGY, 221(18).The Company of Biologists. doi: 10.1242/jeb.183236.

Stifler, C.A., Wittig, N.K., Sassi, M., Sun, C.Y., Marcus, M.A., Birkedal, H., Beniash, E., Rosso, K.M., & Gilbert, P.U.P.A. (2018). X-ray Linear Dichroism in Apatite. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 140(37), 11698-11704.American Chemical Society (ACS). doi: 10.1021/jacs.8b05547.

Beniash, E. (2017). Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis. FRONTIERS IN PHYSIOLOGY, 8(OCT), 823.Frontiers Media SA. doi: 10.3389/fphys.2017.00823.

Ivanina, A.V., Falfushynska, H.I., Beniash, E., Piontkivska, H., & Sokolova, I.M. (2017). Biomineralization-related specialization of hemocytes and mantle tissues of the Pacific oyster Crassostrea gigas. JOURNAL OF EXPERIMENTAL BIOLOGY, 220(18), 3209-3221.The Company of Biologists. doi: 10.1242/jeb.160861.

Patil, A.J., Jackson, O., Fulton, L.B., Hong, D., Desai, P.A., Kelleher, S.A., Chou, D.T., Tan, S., Kumta, P.N., & Beniash, E. (2017). Anticorrosive Self-Assembled Hybrid Alkylsilane Coatings for Resorbable Magnesium Metal Devices. ACS BIOMATERIALS SCIENCE & ENGINEERING, 3(4), 518-529.American Chemical Society (ACS). doi: 10.1021/acsbiomaterials.6b00585.

Yamazaki, H., Beniash, E., Yamakoshi, Y., Simmer, J.P., & Margolis, H.C. (2017). Protein Phosphorylation and Mineral Binding Affect the Secondary Structure of the Leucine-Rich Amelogenin Peptide. FRONTIERS IN PHYSIOLOGY, 8(JUN), 450.Frontiers Media SA. doi: 10.3389/fphys.2017.00450.

Yang, X., Vidunas, A.J., & Beniash, E. (2017). Optimizing Immunostaining of Enamel Matrix: Application of Sudan Black B and Minimization of False Positives from Normal Sera and IgGs. FRONTIERS IN PHYSIOLOGY, 8(APR), 239.Frontiers Media SA. doi: 10.3389/fphys.2017.00239.

Chaudhary, S.C., Kuzynski, M., Bottini, M., Beniash, E., Dokland, T., Mobley, C.G., Yadav, M.C., Poliard, A., Kellermann, O., Millan, J.L., & Napierala, D. (2016). Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro. MATRIX BIOLOGY, 52-54, 284-300.Elsevier BV. doi: 10.1016/j.matbio.2016.02.003.

Dickinson, G.H., Yang, X., Wu, F., Orihuela, B., Rittschof, D., & Beniash, E. (2016). Localization of Phosphoproteins within the Barnacle Adhesive Interface. BIOLOGICAL BULLETIN, 230(3), 233-242. doi: 10.1086/BBLv230n3p233.

Dickinson, G.H., Yang, X., Wu, F., Orihuela, B., Rittschof, D., & Beniash, E. (2016). Localization of Phosphoproteins within the Barnacle Adhesive Interface. BIOLOGICAL BULLETIN, 231(3), 233-242.University of Chicago Press. doi: 10.1086/bblv230n3p233.

Duverger, O., Beniash, E., & Morasso, M.I. (2016). Keratins as components of the enamel organic matrix. MATRIX BIOLOGY, 52-54, 260-265.Elsevier BV. doi: 10.1016/j.matbio.2015.12.007.

Verdelis, K., Szabo-Rogers, H.L., Xu, Y., Chong, R., Kang, R., Cusack, B.J., Jani, P., Boskey, A.L., Qin, C., & Beniash, E. (2016). Accelerated enamel mineralization in Dspp mutant mice. MATRIX BIOLOGY, 52-54, 246-259.Elsevier BV. doi: 10.1016/j.matbio.2016.01.003.

Bagwe, R., Beniash, E., & Sokolova, I.M. (2015). Effects of cadmium exposure on critical temperatures of aerobic metabolism in eastern oysters Crassostrea virginica (Gmelin, 1791). AQUATIC TOXICOLOGY, 167, 77-89.Elsevier BV. doi: 10.1016/j.aquatox.2015.07.012.

Ivanina, A.V., Hawkins, C., Beniash, E., & Sokolova, I.M. (2015). Effects of environmental hypercapnia and metal (Cd and Cu) exposure on acid-base and metal homeostasis of marine bivalves. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 174(1), 1-12.Elsevier BV. doi: 10.1016/j.cbpc.2015.05.001.

Duverger, O., Ohara, T., Shaffer, J.R., Donahue, D., Zerfas, P., Dullnig, A., Crecelius, C., Beniash, E., Marazita, M.L., & Morasso, M.I. (2014). Hair keratin mutations in tooth enamel increase dental decay risk. JOURNAL OF CLINICAL INVESTIGATION, 124(12), 5219-5224.American Society for Clinical Investigation. doi: 10.1172/JCI78272.

Fang, P.A., Verdelis, K., Yang, X., Lukashova, L., Boskey, A.L., & Beniash, E. (2014). Ultrastructural organization of dentin in mice lacking dentin sialo-phosphoprotein. CONNECTIVE TISSUE RESEARCH, 55(sup1), 92-96.Informa UK Limited. doi: 10.3109/03008207.2014.923861.

Goetze, S., Matoo, O.B., Beniash, E., Saborowski, R., & Sokolova, I.M. (2014). Interactive effects of CO2 and trace metals on the proteasome activity and cellular stress response of marine bivalves Crassostrea virginica and Mercenaria mercenaria. AQUATIC TOXICOLOGY, 149, 65-82.Elsevier BV. doi: 10.1016/j.aquatox.2014.01.027.

Hu, J.C.C., Hu, Y., Lu, Y., Smith, C.E., Lertlam, R., Wright, J.T., Suggs, C., McKee, M.D., Beniash, E., Kabir, M.E., & Simmer, J.P. (2014). Enamelin Is Critical for Ameloblast Integrity and Enamel Ultrastructure Formation. In van Wijnen, A. (Ed.). PLOS ONE, 9(3), e89303.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0089303.

Kwak, S.Y., Kim, S., Yamakoshi, Y., Simmer, J.P., Beniash, E., & Margolis, H.C. (2014). Regulation of calcium phosphate formation by native amelogenins in vitro. CONNECTIVE TISSUE RESEARCH, 55(sup1), 21-24.Informa UK Limited. doi: 10.3109/03008207.2014.923853.

Sfeir, C., Fang, P.A., Jayaraman, T., Raman, A., Xiaoyuan, Z., & Beniash, E. (2014). Synthesis of bone-like nanocomposites using multiphosphorylated peptides. ACTA BIOMATERIALIA, 10(5), 2241-2249.Elsevier BV. doi: 10.1016/j.actbio.2014.01.007.

Boskey, A.L., Verdelis, K., Spevak, L., Lukashova, L., Beniash, E., Yang, X., Cabral, W.A., & Marini, J.C. (2013). Mineral and Matrix Changes in Brtl/ plus Teeth Provide Insights into Mineralization Mechanisms. BIOMED RESEARCH INTERNATIONAL, 2013, 295812.Hindawi Limited. doi: 10.1155/2013/295812.

Cantaert, B., Beniash, E., & Meldrum, F.C. (2013). Nanoscale Confinement Controls the Crystallization of Calcium Phosphate: Relevance to Bone Formation. CHEMISTRY-A EUROPEAN JOURNAL, 19(44), 14918-14924.Wiley. doi: 10.1002/chem.201302835.

Cantaert, B., Beniash, E., & Meldrum, F.C. (2013). The role of poly(aspartic acid) in the precipitation of calcium phosphate in confinement. JOURNAL OF MATERIALS CHEMISTRY B, 1(48), 6586-6595.Royal Society of Chemistry (RSC). doi: 10.1039/c3tb21296c.

Cui, W., Beniash, E., Gawalt, E., Xu, Z., & Sfeir, C. (2013). Biomimetic coating of magnesium alloy for enhanced corrosion resistance and calcium phosphate deposition. ACTA BIOMATERIALIA, 9(10), 8650-8659.Elsevier BV. doi: 10.1016/j.actbio.2013.06.031.

Dickinson, G.H., Matoo, O.B., Tourek, R.T., Sokolova, I.M., & Beniash, E. (2013). Environmental salinity modulates the effects of elevated CO2 levels on juvenile hard-shell clams, Mercenaria mercenaria. JOURNAL OF EXPERIMENTAL BIOLOGY, 216(14), 2607-2618.The Company of Biologists. doi: 10.1242/jeb.082909.

Fang, P.A., Margolis, H.C., Conway, J.F., Simmer, J.P., & Beniash, E. (2013). CryoTEM study of effects of phosphorylation on the hierarchical assembly of porcine amelogenin and its regulation of mineralization in vitro. JOURNAL OF STRUCTURAL BIOLOGY, 183(2), 250-257.Elsevier BV. doi: 10.1016/j.jsb.2013.05.011.

Ivanina, A.V., Beniash, E., Etzkorn, M., Meyers, T.B., Ringwood, A.H., & Sokolova, I.M. (2013). Short-term acute hypercapnia affects cellular responses to trace metals in the hard clams Mercenaria mercenaria. AQUATIC TOXICOLOGY, 140, 123-133.Elsevier BV. doi: 10.1016/j.aquatox.2013.05.019.

Ivanina, A.V., Dickinson, G.H., Matoo, O.B., Bagwe, R., Dickinson, A., Beniash, E., & Sokolova, I.M. (2013). Interactive effects of elevated temperature and CO2 levels on energy metabolism and biomineralization of marine bivalves Crassostrea virginica and Mercenaria mercenaria. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 166(1), 101-111.Elsevier BV. doi: 10.1016/j.cbpa.2013.05.016.

Matoo, O., Dickinson, G., Ivanina, A., Beniash, E., & Sokolova, I. (2013). Elevated CO2, temperature and salinity interactively affect biomineralization and shell properties of hard shell clams Mercenaria mercenaria. INTEGRATIVE AND COMPARATIVE BIOLOGY, 53, E327.

Matoo, O.B., Ivanina, A.V., Ullstad, C., Beniash, E., & Sokolova, I.M. (2013). Interactive effects of elevated temperature and CO2 levels on metabolism and oxidative stress in two common marine bivalves (Crassostrea virginica and Mercenaria mercenaria). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 164(4), 545-553.Elsevier BV. doi: 10.1016/j.cbpa.2012.12.025.

Sokolova, I., Ivanina, A., & Beniash, E. (2013). Elevated CO2 levels affect cellular uptake and homeostasis of trace metals in hard shell clams Mercenaria mercenaria. INTEGRATIVE AND COMPARATIVE BIOLOGY, 53, E373.

Syed-Picard, F.N., Jayaraman, T., Lam, R.S.K., Beniash, E., & Sfeir, C. (2013). Osteoinductivity of calcium phosphate mediated by connexin 43. BIOMATERIALS, 34(15), 3763-3774.Elsevier BV. doi: 10.1016/j.biomaterials.2013.01.095.

Beniash, E., Simmer, J.P., & Margolis, H.C. (2012). Structural Changes in Amelogenin upon Self-assembly and Mineral Interactions. JOURNAL OF DENTAL RESEARCH, 91(10), 967-972.SAGE Publications. doi: 10.1177/0022034512457371.

Dickinson, G.H., Ivanina, A.V., Matoo, O.B., Poertner, H.O., Lannig, G., Bock, C., Beniash, E., & Sokolova, I.M. (2012). Interactive effects of salinity and elevated CO2 levels on juvenile eastern oysters, Crassostrea virginica. JOURNAL OF EXPERIMENTAL BIOLOGY, 215(1), 29-43.The Company of Biologists. doi: 10.1242/jeb.061481.

Dickinson, G.H., Matoo, O.B., Beniash, E., & Sokolova, I.M. (2012). THE NORTHERN QUAHOG (=HARD CLAM), MERCENARIA MERCENARIA IN A CHANGING OCEAN: INTERACTIVE EFFECTS OF ELEVATED CO2, TEMPERATURE AND SALINITY ON PHYSIOLOGY AND SHELL PROPERTIES. JOURNAL OF SHELLFISH RESEARCH, 31(1), 275-276.

Fang, P., Beniash, E., Conway, J., Margolis, H., & Simmer, J. (2012). Cryo-TEM Study on Hierarchical Self-assembly of Amelogenin and Regulation of Biomineralization at the Nanoscale. Microscopy and Microanalysis, 18(S2), 1588-1589.Cambridge University Press (CUP). doi: 10.1017/s1431927612009798.

Lam, R.S.K., Metzler, R.A., Gilbert, P.U.P.A., & Beniash, E. (2012). Anisotropy of Chemical Bonds in Collagen Molecules Studied by X-ray Absorption Near-Edge Structure (XANES) Spectroscopy. ACS CHEMICAL BIOLOGY, 7(3), 476-480.American Chemical Society (ACS). doi: 10.1021/cb200260d.

Sokolova, I., Ivanina, A., Matoo, O., Dickinson, G., & Beniash, E. (2012). Interactive effects of elevated CO2, temperature and salinity on physiology and shell properties of hard shell clams Mercenaria mercenaria. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 163(1), S9.Elsevier BV. doi: 10.1016/j.cbpa.2012.05.031.

Beniash, E. (2011). Biominerals-hierarchical nanocomposites: the example of bone. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 3(1), 47-69.Wiley. doi: 10.1002/wnan.105.

Beniash, E., Deshpande, A.S., Fang, P.A., Lieb, N.S., Zhang, X., & Sfeir, C.S. (2011). Possible role of DMP1 in dentin mineralization. JOURNAL OF STRUCTURAL BIOLOGY, 174(1), 100-106.Elsevier BV. doi: 10.1016/j.jsb.2010.11.013.

Deshpande, A.S., Fang, P.A., Zhang, X., Jayaraman, T., Sfeir, C., & Beniash, E. (2011). Primary Structure and Phosphorylation of Dentin Matrix Protein 1 (DMP1) and Dentin Phosphophoryn (DPP) Uniquely Determine Their Role in Biomineralization. BIOMACROMOLECULES, 12(8), 2933-2945.American Chemical Society (ACS). doi: 10.1021/bm2005214.

Fang, P.A., Conway, J.F., Margolis, H.C., Simmer, J.P., & Beniash, E. (2011). Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(34), 14097-14102.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1106228108.

Fang, P.A., Lam, R.S.K., & Beniash, E. (2011). Relationships between dentin and enamel mineral at the dentino-enamel boundary: electron tomography and high-resolution transmission electron microscopy study. EUROPEAN JOURNAL OF ORAL SCIENCES, 119(SUPPL.1), 120-124.Wiley. doi: 10.1111/j.1600-0722.2011.00876.x.

Fang, P.A., Margolis, H.C., Conway, J.F., Simmer, J.P., Dickinson, G.H., & Beniash, E. (2011). Cryogenic Transmission Electron Microscopy Study of Amelogenin Self-Assembly at Different pH. CELLS TISSUES ORGANS, 194(2-4), 166-170.S. Karger AG. doi: 10.1159/000324250.

Kwak, S.Y., Green, S., Wiedemann-Bidlack, F.B., Beniash, E., Yamakoshi, Y., Simmer, J.P., & Margolis, H.C. (2011). Regulation of calcium phosphate formation by amelogenins under physiological conditions. EUROPEAN JOURNAL OF ORAL SCIENCES, 119(SUPPL.1), 103-111.Wiley. doi: 10.1111/j.1600-0722.2011.00911.x.

Le Norcy, E., Kwak, S.Y., Wiedemann-Bidlack, F.B., Beniash, E., Yamakoshi, Y., Simmer, J.P., & Margolis, H.C. (2011). Leucine-rich Amelogenin Peptides Regulate Mineralization in vitro. JOURNAL OF DENTAL RESEARCH, 90(9), 1091-1097.SAGE Publications. doi: 10.1177/0022034511411301.

Le Norcy, E., Kwak, S.Y., Wiedemann-Bidlack, F.B., Beniash, E., Yamakoshi, Y., Simmer, J.P., & Margolis, H.C. (2011). Potential Role of the Amelogenin N-Terminus in the Regulation of Calcium Phosphate Formation in vitro. CELLS TISSUES ORGANS, 194(2-4), 188-193.S. Karger AG. doi: 10.1159/000324827.

Tomanek, L., Zuzow, M.J., Ivanina, A.V., Beniash, E., & Sokolova, I.M. (2011). Proteomic response to elevated P-CO2 level in eastern oysters, Crassostrea virginica: evidence for oxidative stress. JOURNAL OF EXPERIMENTAL BIOLOGY, 214(11), 1836-1844.The Company of Biologists. doi: 10.1242/jeb.055475.

Watkins, M., Grimston, S.K., Norris, J.Y., Guillotin, B., Shaw, A., Beniash, E., & Civitelli, R. (2011). Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling. MOLECULAR BIOLOGY OF THE CELL, 22(8), 1240-1251.American Society for Cell Biology (ASCB). doi: 10.1091/mbc.E10-07-0571.

Wiedemann-Bidlack, F.B., Kwak, S.Y., Beniash, E., Yamakoshi, Y., Simmer, J.P., & Margolis, H.C. (2011). Effects of phosphorylation on the self-assembly of native full-length porcine amelogenin and its regulation of calcium phosphate formation in vitro. JOURNAL OF STRUCTURAL BIOLOGY, 173(2), 250-260.Elsevier BV. doi: 10.1016/j.jsb.2010.11.006.

Beniash, E., Ivanina, A., Lieb, N.S., Kurochkin, I., & Sokolova, I.M. (2010). Elevated level of carbon dioxide affects metabolism and shell formation in oysters Crassostrea virginica. MARINE ECOLOGY PROGRESS SERIES, 419(0), 95-108.Inter-Research Science Center. doi: 10.3354/meps08841.

Deshpande, A.S., Fang, P.A., Simmer, J.P., Margolis, H.C., & Beniash, E. (2010). Amelogenin-Collagen Interactions Regulate Calcium Phosphate Mineralization in Vitro. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(25), 19277-19287.Elsevier BV. doi: 10.1074/jbc.M109.079939.

Beniash, E., Metzler, R.A., Lam, R.S.K., & Gilbert, P.U.P.A. (2009). Transient amorphous calcium phosphate in forming enamel. JOURNAL OF STRUCTURAL BIOLOGY, 166(2), 133-143.Elsevier BV. doi: 10.1016/j.jsb.2009.02.001.

Beniash, E., Metzler, R.A., Lam, R.S.K., & Gilbert, P.U.P.A. (2009). Transient amorphous calcium phosphate in forming enamel (vol 166, pg 133, 2009). JOURNAL OF STRUCTURAL BIOLOGY, 167(1), 95.Elsevier BV. doi: 10.1016/j.jsb.2009.04.002.

Kwak, S.Y., Wiedemann-Bidlack, F.B., Beniash, E., Yamakoshi, Y., Simmer, J.P., Litman, A., & Margolis, H.C. (2009). Role of 20-kDa Amelogenin (P148) Phosphorylation in Calcium Phosphate Formation in Vitro. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(28), 18972-18979.Elsevier BV. doi: 10.1074/jbc.M109.020370.

Baldassarri, M., Margolis, H.C., & Beniash, E. (2008). Compositional determinants of mechanical properties of enamel. JOURNAL OF DENTAL RESEARCH, 87(7), 645-649.SAGE Publications. doi: 10.1177/154405910808700711.

Deshpande, A.S., & Beniash, E. (2008). Bioinspired synthesis of mineralized collagen fibrils. CRYSTAL GROWTH & DESIGN, 8(8), 3084-3090.American Chemical Society (ACS). doi: 10.1021/cg800252f.

Metzler, R.A., Kim, I.W., Delak, K., Evans, J.S., Zhou, D., Beniash, E., Wilt, F., Abrecht, M., Chiou, J.W., Guo, J., Coppersmith, S.N., & Gilbert, P.U.P.A. (2008). Probing the organic-mineral interface at the molecular level in model biominerals. LANGMUIR, 24(6), 2680-2687.American Chemical Society (ACS). doi: 10.1021/la7031237.

Metzler, R.A., Kim, I.W., Delak, K., Evans, J.S., Zhou, D., Beniash, E., Wilt, F., Killian, C.E., Abrecht, M., Chiou, J.W., Guo, J., Coppersmith, S.N., & Gilbert, P.U.P.A. (2008). Probing the organic-mineral interface at the molecular level in model biominerals. In Geochimica Et Cosmochimica Acta. Materials Research Society Symposium Proceedings, 1131, (pp. 1-6).

Elangovan, S., Margolis, H.C., Oppenheim, F.G., & Beniash, E. (2007). Conformational changes in salivary proline-rich protein 1 upon adsorption to calcium phosphate crystalsle. LANGMUIR, 23(22), 11200-11205.American Chemical Society (ACS). doi: 10.1021/la7013978.

Wiedemann-Bidlack, F.B., Beniash, E., Yamakoshi, Y., Simmer, J.P., & Margolis, H.C. (2007). pH triggered self-assembly of native and recombinant amelogenins under physiological pH and temperature in vitro. JOURNAL OF STRUCTURAL BIOLOGY, 160(1), 57-69.Elsevier BV. doi: 10.1016/j.jsb.2007.06.007.

Beniash, E., Skobe, Z., & Bartlett, J.D. (2006). Formation of the dentino-enamel interface in enamelysin (MMP-20)-deficient mouse incisors. EUROPEAN JOURNAL OF ORAL SCIENCES, 114(s1), 24-29.Wiley. doi: 10.1111/j.1600-0722.2006.00293.x.

Fowler, C.E., Beniash, E., Yamakoshi, Y., Simmer, J.P., & Margolis, H.C. (2006). Co-operative mineralization and protein self-assembly in amelogenesis: silica mineralization and assembly of recombinant amelogenins in vitro. EUROPEAN JOURNAL OF ORAL SCIENCES, 114(s1), 297-303.Wiley. doi: 10.1111/j.1600-0722.2006.00288.x.

Margolis, H.C., Beniash, E., & Fowler, C.E. (2006). Role of macromolecular assembly of enamel matrix proteins in enamel formation. JOURNAL OF DENTAL RESEARCH, 85(9), 775-793.SAGE Publications. doi: 10.1177/154405910608500902.

Bartlett, J.D., Dwyer, S.E., Beniash, E., Skobe, Z., & Payne-Ferreira, T.L. (2005). Fluorosis: A new model and new insights. JOURNAL OF DENTAL RESEARCH, 84(9), 832-836.SAGE Publications. doi: 10.1177/154405910508400910.

Beniash, E., Hartgerink, J.D., Storrie, H., Stendahl, J.C., & Stupp, S.I. (2005). Self-assembling peptide amphiphile nanofiber matrices for cell entrapment. ACTA BIOMATERIALIA, 1(4), 387-397.Elsevier BV. doi: 10.1016/j.actbio.2005.04.002.

Beniash, E., Simmer, J.P., & Margolis, H.C. (2005). The effect of recombinant mouse amelogenins on the formation and organization of hydroxyapatite crystals in vitro. JOURNAL OF STRUCTURAL BIOLOGY, 149(2), 182-190.Elsevier BV. doi: 10.1016/j.jsb.2004.11.001.

Bartlett, J.D., Beniash, E., Lee, D.H., & Smith, C.E. (2004). Decreased mineral content in MMP-20 null mouse enamel is prominent during the maturation stage. JOURNAL OF DENTAL RESEARCH, 83(12), 909-913.SAGE Publications. doi: 10.1177/154405910408301204.

Silva, G.A., Czeisler, C., Niece, K.L., Beniash, E., Harrington, D.A., Kessler, J.A., & Stupp, S.I. (2004). Selective differentiation of neural progenitor cells by high-epitope density nanofibers. SCIENCE, 303(5662), 1352-1355.American Association for the Advancement of Science (AAAS). doi: 10.1126/science.1093783.

Ellingsen, J.E., & Lyngstadaas, S.P. (2003). Bio-Implant Interface. In Bio-Implant Interface: Improving Biomaterials and Tissue Reactions. (pp. 393-406).CRC Press. doi: 10.1201/9780203491430.

Li, L.M., Beniash, E., Zubarev, E.R., Xiang, W.H., Rabatic, B.M., Zhang, G.Z., & Stupp, S.I. (2003). Assembling a lasing hybrid material with supramolecular polymers and nanocrystals. NATURE MATERIALS, 2(10), 689-694.Springer Science and Business Media LLC. doi: 10.1038/nmat983.

Hartgerink, J.D., Beniash, E., & Stupp, S.I. (2002). Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(8), 5133-5138.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.072699999.

Hartgerink, J.D., Beniash, E., & Stupp, S.I. (2001). Self-assembly and mineralization of peptide-amphiphile nanofibers. SCIENCE, 294(5547), 1684-1688.American Association for the Advancement of Science (AAAS). doi: 10.1126/science.1063187.

Beniash, E., Traub, W., Veis, A., & Weiner, S. (2000). A transmission electron microscope study using vitrified ice sections of predentin: Structural changes in the dentin collagenous matrix prior to mineralization. JOURNAL OF STRUCTURAL BIOLOGY, 132(3), 212-225.Elsevier BV. doi: 10.1006/jsbi.2000.4320.

Beniash, E., Addadi, L., & Weiner, S. (1999). Cellular control over spicule formation in sea urchin embryos: A structural approach. JOURNAL OF STRUCTURAL BIOLOGY, 125(1), 50-62.Elsevier BV. doi: 10.1006/jsbi.1998.4081.

Weiner, S., Veis, A., Beniash, E., Arad, T., Dillon, J.W., Sabsay, B., & Siddiqui, F. (1999). Peritubular dentin formation: Crystal organization and the macromolecular constituents in human teeth. JOURNAL OF STRUCTURAL BIOLOGY, 126(1), 27-41.Elsevier BV. doi: 10.1006/jsbi.1999.4096.

Beniash, E., Aizenberg, J., Addadi, L., & Weiner, S. (1997). Amorphous calcium carbonate transforms into calcite during sea urchin larval spicule growth. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 264(1380), 461-465.The Royal Society. doi: 10.1098/rspb.1997.0066.

Beniash, E., Aizenberg, J., Weiner, S., & Addadi, L. (1997). Amorphous calcium carbonate transforms into calcite during sea urchin larval spicule growth. Proc. Roy. Soc. London, B, 264(0), 461-465.

Beniash, E., Yerlikkova, N., & Yevdonin, L. (1993). On anatomy of nervous system of Dinophilus vorticoides. Explorations of the fauna of the Seas, Zoological Institute, Russ. Acad. Sci., 43(51), 5-9.

Fang, P.A., Conway, J.F., Margolis, H.C., Simmer, J.P., & Beniash, E. (2011). Supramolecular assemblies of amelogenin guide organization of calcium phosphate prenucleation clusters into highly ordered mesostructures. ACS National Meeting.Denver, CO.

Research interests

biomaterials
biomineralization
bone diseases, developmental
carbon dioxide
crassostrea
dentin
interface
osteoblasts
self-assembly
structural biology