Amanda Clark

Dai, B., Clark, A.M., & Wells, A. (2024). Mesenchymal Stem Cell-Secreted Exosomes and Soluble Signals Regulate Breast Cancer Metastatic Dormancy: Current Progress and Future Outlook. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(13), 7133.MDPI. doi: 10.3390/ijms25137133.

McDonald, J.C., & Clark, A.M. (2024). Modeling Tumor Cell Dormancy in an Ex Vivo Liver Metastatic Niche. Methods in Molecular Biology, 2811, 37-53.Springer Nature. doi: 10.1007/978-1-0716-3882-8_3.

Korentzelos, D., Wells, A., & Clark, A.M. (2022). Interferon-γ increases sensitivity to chemotherapy and provides immunotherapy targets in models of metastatic castration-resistant prostate cancer. SCIENTIFIC REPORTS, 12(1), 6657.Springer Nature. doi: 10.1038/s41598-022-10724-9.

Clark, A.M. (2021). Modeling the Complexity of the Metastatic Niche Ex Vivo. Methods in Molecular Biology, 2258, 221-239.Springer Nature. doi: 10.1007/978-1-0716-1174-6_15.

Clark, A.M., Allbritton, N.L., & Wells, A. (2021). Integrative microphysiological tissue systems of cancer metastasis to the liver. SEMINARS IN CANCER BIOLOGY, 71, 157-169.Elsevier. doi: 10.1016/j.semcancer.2020.06.010.

Clark, A.M., Heusey, H.L., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2021). IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment. FRONTIERS IN ONCOLOGY, 11, 676135.Frontiers. doi: 10.3389/fonc.2021.676135.

Clark, A.M., Magawa, C., Pliego-Zamora, A., Low, P., Reynolds, M., & Ralph, S.J. (2021). Tea tree oil extract causes mitochondrial superoxide production and apoptosis as an anticancer agent, promoting tumor infiltrating neutrophils cytotoxic for breast cancer to induce tumor regression. BIOMEDICINE & PHARMACOTHERAPY, 140, 111790.Elsevier. doi: 10.1016/j.biopha.2021.111790.

Marti, J.L.G., Beckwitt, C.H., Clark, A.M., & Wells, A. (2021). Atorvastatin facilitates chemotherapy effects in metastatic triple-negative breast cancer. BRITISH JOURNAL OF CANCER, 125(9), 1285-1298.Springer Nature. doi: 10.1038/s41416-021-01529-0.

Korentzelos, D., Clark, A.M., & Wells, A. (2020). A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(19), 7304.MDPI. doi: 10.3390/ijms21197304.

Ma, B., Wells, A., & Clark, A.M. (2020). The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment. SEMINARS IN CANCER BIOLOGY, 60, 138-147.Elsevier. doi: 10.1016/j.semcancer.2019.07.021.

Jiang, Y., Wells, A., Sylakowski, K., Clark, A.M., & Ma, B. (2019). Adult Stem Cell Functioning in the Tumor Micro-Environment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(10), 2566.MDPI. doi: 10.3390/ijms20102566.

Beckwitt, C.H., Clark, A.M., Ma, B., Whaley, D., Oltvai, Z.N., & Wells, A. (2018). Statins attenuate outgrowth of breast cancer metastases. BRITISH JOURNAL OF CANCER, 119(9), 1094-1105.Springer Nature. doi: 10.1038/s41416-018-0267-7.

Beckwitt, C.H., Clark, A.M., Wheeler, S., Taylor, D.L., Stolz, D.B., Griffith, L., & Wells, A. (2018). Liver 'organ on a chip'. EXPERIMENTAL CELL RESEARCH, 363(1), 15-25.Elsevier. doi: 10.1016/j.yexcr.2017.12.023.

Clark, A.M., Kumar, M.P., Wheeler, S.E., Young, C.L., Venkataramanan, R., Stolz, D.B., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2018). A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. MOLECULAR & CELLULAR PROTEOMICS, 17(4), 619-630.Elsevier. doi: 10.1074/mcp.RA117.000370.

Khazali, A.S., Clark, A.M., & Wells, A. (2018). Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy. BRITISH JOURNAL OF CANCER, 118(4), 566-576.Springer Nature. doi: 10.1038/bjc.2017.414.

Wells, A., Clark, A., Bradshaw, A., Ma, B., & Edington, H. (2018). The great escape: How metastases of melanoma, and other carcinomas, avoid elimination. EXPERIMENTAL BIOLOGY AND MEDICINE, 243(17-18), 1245-1255.Frontiers. doi: 10.1177/1535370218820287.

Clark, A.M., Wheeler, S.E., Young, C.L., Stockdale, L., Neiman, J.S., Zhao, W., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2017). A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. LAB ON A CHIP, 17(1), 156-168.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc01171c.

Dioufa, N., Clark, A.M., Ma, B., Beckwitt, C.H., & Wells, A. (2017). Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. MOLECULAR CANCER, 16(1), 172.Springer Nature. doi: 10.1186/s12943-017-0740-6.

Khazali, A.S., Clark, A.M., & Wells, A. (2017). A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms. STEM CELL REVIEWS AND REPORTS, 13(3), 364-380.Springer Nature. doi: 10.1007/s12015-017-9735-3.

Clark, A.M., Ma, B., Taylor, D.L., Griffith, L., & Wells, A. (2016). Liver metastases: Microenvironments and ex-vivo models. EXPERIMENTAL BIOLOGY AND MEDICINE, 241(15), 1639-1652.Frontiers. doi: 10.1177/1535370216658144.

Ma, B., Wheeler, S.E., Clark, A.M., Whaley, D.L., Yang, M., & Wells, A. (2016). Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling. HEPATOLOGY, 64(5), 1725-1742.Wolters Kluwer. doi: 10.1002/hep.28755.

Yang, M., Ma, B., Shao, H., Clark, A.M., & Wells, A. (2016). Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. BMC CANCER, 16(1), 419.Springer Nature. doi: 10.1186/s12885-016-2411-1.

Clark, A.M., Wheeler, S.E., Taylor, D.P., Young, C.L., Pillai, V.C., Stolz, D.B., Venkataramanan, R., Lauffenburger, D.A., Griffith, L.G., & Wells, A. (2015). Modeling breast cancer dormancy and re-emergence. CANCER RESEARCH, 75(9_Supplement), p1-07-01-p1-07-01.American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.SABCS14-P1-07-01.

Furukawa, M., Wheeler, S., Clark, A.M., & Wells, A. (2015). Lung Epithelial Cells Induce Both Phenotype Alteration and Senescence in Breast Cancer Cells. In Samant, R. (Ed.). PLOS ONE, 10(1), e0118060.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0118060.

Low, P., Clark, A.M., Chou, T.C., Chang, T.C., Reynolds, M., & Ralph, S.J. (2015). Immunomodulatory activity of Melaleuca alternifolia concentrate (MAC): Inhibition of LPS-induced NF-κB activation and cytokine production in myeloid cell lines. INTERNATIONAL IMMUNOPHARMACOLOGY, 26(1), 257-264.Elsevier. doi: 10.1016/j.intimp.2015.03.034.

Clark, A.M., Wheeler, S.E., Taylor, D.P., Pillai, V.C., Young, C.L., Prantil-Baun, R., Transon, N., Stolz, D.B., Borenstein, J.T., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2014). A microphysiological system model of therapy for liver micrometastases. EXPERIMENTAL BIOLOGY AND MEDICINE, 239(9), 1170-1179.Frontiers. doi: 10.1177/1535370214532596.

Taylor, D.P., Clark, A., Wheeler, S., & Wells, A. (2014). Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. BREAST CANCER RESEARCH AND TREATMENT, 144(3), 551-560.Springer Nature. doi: 10.1007/s10549-014-2875-0.

Wheeler, S.E., Clark, A.M., Taylor, D.P., Young, C.L., Pillai, V.C., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2014). Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system. BRITISH JOURNAL OF CANCER, 111(12), 2342-2350.Springer Nature. doi: 10.1038/bjc.2014.533.

Horton, R.E., Grant, G.D., Matthews, B., Batzloff, M., Owen, S.J., Kyan, S., Flegg, C.P., Clark, A.M., Ulett, G.C., Morrison, N., Peak, I.R., & Beacham, I.R. (2013). Quorum Sensing Negatively Regulates Multinucleate Cell Formation during Intracellular Growth of Burkholderia pseudomallei in Macrophage-Like Cells. In II, R.M.R. (Ed.). PLOS ONE, 8(5), e63394.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0063394.

Wheeler, S.E., Borenstein, J.T., Clark, A.M., Ebrahimkhani, M., Fox, I.J., Griffith, L., Inman, W., Lauffenburger, D., Transon, N., Pillai, V.C., Prantil-Baun, R., Stolz, D.B., Taylor, D., Ulrich, T., Venkataramanan, R., Wells, A., & Young, C. (2013). All-human microphysical model of metastasis therapy. STEM CELL RESEARCH & THERAPY, 4(Suppl 1), s11.Springer Nature. doi: 10.1186/scrt372.

Ito, K., Stannard, K., Gabutero, E., Clark, A.M., Neo, S.Y., Onturk, S., Blanchard, H., & Ralph, S.J. (2012). Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment. CANCER AND METASTASIS REVIEWS, 31(3-4), 763-778.Springer Nature. doi: 10.1007/s10555-012-9388-2.

Oesterreich, S., Miller, L., Rosenzweig, M.Q., Bartholow, T.L., Yates, M., Elangovan, A., Savariau, L., Casey, A.N., Priedigkeit, N., Ding, K., Wedn, A., Bin Liu, J., Brown, D.D., Hyder, T., Pecar, G., Carleton, N., Bittar, H.T., Geisler, D., Lopez-Nunez, O., Clark, A.M., Wells, A., Roy, P., Puhalla, S., Howard, N., Needles, C., Trent, S., Walker, S., Hodgdon, C., Bhargava, R., Atkinson, J.M., & Lee, A.V. (2023). Hope for OTHERS - An organ donation program for metastatic breast cancer research. In CANCER RESEARCH, 83(5), (p. p6-14-02-p6-14-02).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.SABCS22-P6-14-02.

Beckwitt, C.H., Clark, A.M., Warita, K., Oltvai, Z.N., & Wells, A. (2018). Adjuvant statin therapy efficacy is dictated by tumor dormancy and statin lipophilicity in ex vivo and in vivo models of metastatic breast cancer. In CANCER RESEARCH, 78(4).

Beckwitt, C.H., Clark, A.M., Warita, K., Oltvai, Z.N., & Wells, A. (2017). Adjuvant Statin Therapy Efficacy is Dictated by Tumor Dormancy and Statin Lipophilicity in Ex Vivo and In Vivo Models of Metastatic Breast Cancer. In FASEB JOURNAL, 31.

Clark, A.M., Dioufa, N., Chan, K., Edington, C.D., Kumar, M., Wheeler, S.E., Venkataramanan, R., Stolz, D.B., Trumper, D., Griffith, L., Lauffenburger, D., & Wells, A. (2017). A Multi-Organ Microphysiological System that Models Dormant-Emergent Metastatic Breast Cancer Progression. In AMERICAN JOURNAL OF PATHOLOGY, 187(10), (p. 2356).

Clark, A.M., Wheeler, S.E., Young, C.L., Neiman, J.S., Pillai, V., Stockdale, L., Stolz, D., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2017). Mechanical properties of matrices strongly influence spontaneous tumor dormancy and responses to chemotherapy in a 3D model of metastasis. In CANCER RESEARCH, 77(2_Supplement), (p. a01).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.EPSO16-A01.

Edington, C.D., Cirit, M., Chen, W.L.K., Clark, A.M., Wells, A., Trumper, D.L., & Griffith, L.G. (2017). Integration of systems biology with organs-on-chips to humanize therapeutic development. In Gray, B.L., & Becker, H. (Eds.). In Proceedings of SPIE--the International Society for Optical Engineering, 10061, (p. 1006113-1006113-9).SPIE, the international society for optics and photonics. doi: 10.1117/12.2256078.

Beckwitt, C., Wheeler, S.E., Clark, A.M., Pillai, V.C., Young, C.L., Stolz, D.B., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2016). Breast cancer dormancy, re-emergence, and treatment. In CANCER RESEARCH, 76(4_Supplement), (p. p2-05-19-p2-05-19).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.SABCS15-P2-05-19.

Clark, A.M., Wheeler, S.E., Young, C.L., Pillai, V.C., Stolz, D.B., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2016). Elucidating candidate biomarkers of breast cancer progression and dormancy using a 3D model of metastasis. In CANCER RESEARCH, 76(7_Supplement), (p. a41).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.TUMMET15-A41.

Clark, A.M., Wheeler, S.E., Young, C.L., Pillai, V.C., Stolz, D.B., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2016). Elucidating candidate biomarkers of breast cancer progression and dormancy using a 3D model of metastasis. In CANCER RESEARCH, 76(7_Supplement), (p. pr11).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.TUMMET15-PR11.

Khazali, A.S., Clark, A., Wheeler, S., & Wells, A. (2016). Breast Cancer Emergence from Dormancy can be Activated by Hepatic Stellate Cells. In FASEB JOURNAL, 30.

Nguyen, T.V., Kim, E.S., Coppeta, J.R., Wheeler, S.E., Clark, A.M., Lever, A.R., Cirit, M., Yu, J., Spencer, A.J., Sinatra, F.L., Prantil-Baun, R., Wells, A., Griffith, L.G., & Borenstein, J.T. (2014). Automated reagent delivery, media replenishment, and media sampling platform for open cell culture systems. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, (pp. 491-493).

Wheeler, S.E., Taylor, D.P., Clark, A.M., Borenstein, J.T., Ebrahimkhani, M.R., Inman, W., Nguyen, T., Pillai, V.C., Prantil-Baun, R., Ulrich, T.A., Venkataramanan, R., Lauffenburger, D.A., Griffith, L., Stolz, D.B., & Wells, A. (2013). Modeling breast cancer dormancy. In CANCER RESEARCH, 73(24_Supplement), (p. p5-04-08-p5-04-08).American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.SABCS13-P5-04-08.