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Alan Wells

Professor
Bioengineering Department

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Marti, J.L.G., Beckwitt, C.H., Clark, A.M., & Wells, A. (2021). Atorvastatin facilitates chemotherapy effects in metastatic triple-negative breast cancer. BRITISH JOURNAL OF CANCER, 125(9), 1285-1298.Springer Science and Business Media LLC. doi: 10.1038/s41416-021-01529-0.

Swamynathan, S.K., & Wells, A. (2020). Conjunctival goblet cells: Ocular surface functions, disorders that affect them, and the potential for their regeneration. OCULAR SURFACE, 18(1), 19-26.Elsevier BV. doi: 10.1016/j.jtos.2019.11.005.

Sylakowski, K., Bradshaw, A., & Wells, A. (2020). Mesenchymal Stem Cell/Multipotent Stromal Cell Augmentation of Wound Healing Lessons from the Physiology of Matrix and Hypoxia Support. AMERICAN JOURNAL OF PATHOLOGY, 190(7), 1370-1381.Elsevier BV. doi: 10.1016/j.ajpath.2020.03.017.

Jiang, Y., Wells, A., Sylakowski, K., Clark, A.M., & Ma, B. (2019). Adult Stem Cell Functioning in the Tumor Micro-Environment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(10), 2566.MDPI AG. doi: 10.3390/ijms20102566.

Ma, B., Khazali, M., Shao, H., Jiang, Y., & Wells, A. (2019). Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer. CELL COMMUNICATION AND SIGNALING, 17(1), 164.Springer Science and Business Media LLC. doi: 10.1186/s12964-019-0489-1.

Shao, H., Wingert, B., Weins, A., Pollak, M.R., Camacho, C., & Wells, A. (2019). Focal segmental glomerulosclerosis ACTN4 mutants binding to actin: regulation by phosphomimetic mutations. SCIENTIFIC REPORTS, 9(1), 15517.Springer Science and Business Media LLC. doi: 10.1038/s41598-019-51825-2.

Beckwitt, C.H., Brufsky, A., Oltvai, Z.N., & Wells, A. (2018). Statin drugs to reduce breast cancer recurrence and mortality. BREAST CANCER RESEARCH, 20(1), 144.Springer Science and Business Media LLC. doi: 10.1186/s13058-018-1066-z.

Beckwitt, C.H., Clark, A.M., Ma, B., Whaley, D., Oltvai, Z.N., & Wells, A. (2018). Statins attenuate outgrowth of breast cancer metastases. BRITISH JOURNAL OF CANCER, 119(9), 1094-1105.Springer Science and Business Media LLC. doi: 10.1038/s41416-018-0267-7.

Clark, A.M., Kumar, M.P., Wheeler, S.E., Young, C.L., Venkataramanan, R., Stolz, D.B., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2018). A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. MOLECULAR & CELLULAR PROTEOMICS, 17(4), 619-630.Elsevier BV. doi: 10.1074/mcp.RA117.000370.

Clark, A.M., Wheeler, S.E., Young, C.L., Stockdale, L., Neiman, J.S., Zhao, W., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2017). A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. LAB ON A CHIP, 17(1), 156-168.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc01171c.

Dioufa, N., Clark, A.M., Ma, B., Beckwitt, C.H., & Wells, A. (2017). Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. MOLECULAR CANCER, 16(1), 172.Springer Science and Business Media LLC. doi: 10.1186/s12943-017-0740-6.

Khazali, A.S., Clark, A.M., & Wells, A. (2017). A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms. STEM CELL REVIEWS AND REPORTS, 13(3), 364-380.Springer Science and Business Media LLC. doi: 10.1007/s12015-017-9735-3.

Shao, H., Lauffenburger, D., & Wells, A. (2017). Tyro3 carboxyl terminal region confers stability and contains the autophosphorylation sites. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 490(3), 1074-1079.Elsevier BV. doi: 10.1016/j.bbrc.2017.06.168.

Yates, C.C., Rodrigues, M., Nuschke, A., Johnson, Z.I., Whaley, D., Stolz, D., Newsome, J., & Wells, A. (2017). Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring. STEM CELL RESEARCH & THERAPY, 8(1), 193.Springer Science and Business Media LLC. doi: 10.1186/s13287-017-0644-9.

Clark, A.M., Ma, B., Taylor, D.L., Griffith, L., & Wells, A. (2016). Liver metastases: Microenvironments and ex-vivo models. EXPERIMENTAL BIOLOGY AND MEDICINE, 241(15), 1639-1652.SAGE Publications. doi: 10.1177/1535370216658144.

Ma, B., Wheeler, S.E., Clark, A.M., Whaley, D.L., Yang, M., & Wells, A. (2016). Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling. HEPATOLOGY, 64(5), 1725-1742.Wiley. doi: 10.1002/hep.28755.

Nuschke, A., Rodrigues, M., Rivera, J., Yates, C., Whaley, D., Stolz, D., Griffith, L., & Wells, A. (2016). Epidermal Growth Factor Tethered to beta-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. STEM CELLS TRANSLATIONAL MEDICINE, 5(11), 1580-1586.Wiley. doi: 10.5966/sctm.2015-0326.

Nuschke, A., Rodrigues, M., Wells, A.W., Sylakowski, K., & Wells, A. (2016). Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation. STEM CELL RESEARCH & THERAPY, 7(1), 179.Springer Science and Business Media LLC. doi: 10.1186/s13287-016-0436-7.

Wells, A., Nuschke, A., & Yates, C.C. (2016). Skin tissue repair: Matrix microenvironmental influences. MATRIX BIOLOGY, 49, 25-36.Elsevier BV. doi: 10.1016/j.matbio.2015.08.001.

Yang, M., Ma, B., Shao, H., Clark, A.M., & Wells, A. (2016). Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. BMC CANCER, 16(1), 419.Springer Science and Business Media LLC. doi: 10.1186/s12885-016-2411-1.

Furukawa, M., Wheeler, S., Clark, A.M., & Wells, A. (2015). Lung Epithelial Cells Induce Both Phenotype Alteration and Senescence in Breast Cancer Cells. In Samant, R. (Ed.). PLOS ONE, 10(1), e0118060.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0118060.

Clark, A.M., Wheeler, S.E., Taylor, D.P., Pillai, V.C., Young, C.L., Prantil-Baun, R., Nguyen, T., Stolz, D.B., Borenstein, J.T., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2014). A microphysiological system model of therapy for liver micrometastases. EXPERIMENTAL BIOLOGY AND MEDICINE, 239(9), 1170-1179.SAGE Publications. doi: 10.1177/1535370214532596.

Jamison, J., Wang, J.H.C., & Wells, A. (2014). PKC delta Regulates Force Signaling during VEGF/CXCL4 Induced Dissociation of Endothelial Tubes. In Hotchin, N.A. (Ed.). PLOS ONE, 9(4), e93968.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0093968.

Ma, B., & Wells, A. (2014). The Mitogen-activated Protein ( MAP) Kinases p38 and Extracellular Signal-regulated Kinase ( ERK) Are Involved in Hepatocyte-mediated Phenotypic Switching in Prostate Cancer Cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(16), 11153-11161.Elsevier BV. doi: 10.1074/jbc.M113.540237.

Nuschke, A., Rodrigues, M., Stolz, D.B., Chu, C.T., Griffith, L., & Wells, A. (2014). Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation. STEM CELL RESEARCH & THERAPY, 5(6), 140.Springer Science and Business Media LLC. doi: 10.1186/scrt530.

Shao, H., Li, S., Watkins, S.C., & Wells, A. (2014). alpha-Actinin-4 Is Required for Amoeboid-type Invasiveness of Melanoma Cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(47), 32717-32728.Elsevier BV. doi: 10.1074/jbc.M114.579185.

Wells, A., Grahovac, J., Wheeler, S., Ma, B., & Lauffenburger, D. (2013). Targeting tumor cell motility as a strategy against invasion and metastasis. TRENDS IN PHARMACOLOGICAL SCIENCES, 34(5), 283-289.Elsevier BV. doi: 10.1016/j.tips.2013.03.001.

Wells, A., Griffith, L., Wells, J.Z., & Taylor, D.P. (2013). The Dormancy Dilemma: Quiescence versus Balanced Proliferation. CANCER RESEARCH, 73(13), 3811-3816.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-13-0356.

Wheeler, S.E., Borenstein, J.T., Clark, A.M., Ebrahimkhani, M., Fox, I.J., Griffith, L., Inman, W., Lauffenburger, D., Nguyen, T., Pillai, V.C., Prantil-Baun, R., Stolz, D.B., Taylor, D., Ulrich, T., Venkataramanan, R., Wells, A., & Young, C. (2013). All-human microphysical model of metastasis therapy. STEM CELL RESEARCH & THERAPY, 4(S1), S11.Springer Science and Business Media LLC. doi: 10.1186/scrt372.

Wells, A. (2012). Laboratory medicine: a view to the future of diagnostics and training. Rinsho Byori, 60(4), 312-320.

Wu, Q., Dhir, R., & Wells, A. (2012). Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion. MOLECULAR CANCER, 11(1), 3.Springer Science and Business Media LLC. doi: 10.1186/1476-4598-11-3.

Yates-Binder, C.C., Rodgers, M., Jaynes, J., Wells, A., Bodnar, R.J., & Turner, T. (2012). An IP-10 (CXCL10)-Derived Peptide Inhibits Angiogenesis. In Proost, P. (Ed.). PLOS ONE, 7(7), e40812.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0040812.

Wells, A., Chao, Y.L., Grahovac, J., Wu, Q., & Lauffenburger, D.A. (2011). Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. FRONTIERS IN BIOSCIENCE-LANDMARK, 16(1), 815-837.Bioscience Research Institute Pte. Ltd. doi: 10.2741/3722.

Leloup, L., Shao, H., Bae, Y.H., Deasy, B., Stolz, D., Roy, P., & Wells, A. (2010). m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(43), 33549-33566.Elsevier BV. doi: 10.1074/jbc.M110.123604.

Rodrigues, M., Griffith, L.G., & Wells, A. (2010). Growth factor regulation of proliferation and survival of multipotential stromal cells. STEM CELL RESEARCH & THERAPY, 1(4), 32.Springer Science and Business Media LLC. doi: 10.1186/scrt32.

Shao, H., Wang, J.H.C., Pollak, M.R., & Wells, A. (2010). alpha-Actinin-4 Is Essential for Maintaining the Spreading, Motility and Contractility of Fibroblasts. In Hotchin, N.A. (Ed.). PLOS ONE, 5(11), e13921.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0013921.

Wells, A. (2010). Genetics of Neurologic and Psychiatric Diseases Preface. CLINICS IN LABORATORY MEDICINE, 30(4), XIII-XIV.Elsevier BV. doi: 10.1016/j.cll.2010.07.012.

Wells, A., Yates, C., & Shepard, C.R. (2008). E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. CLINICAL & EXPERIMENTAL METASTASIS, 25(6), 621-628.Springer Science and Business Media LLC. doi: 10.1007/s10585-008-9167-1.

Wells, A., & Smith, B.R. (2007). The goals of resident training in laboratory medicine in combined anatomic pathology/clinical pathology programs: An overview. CLINICS IN LABORATORY MEDICINE, 27(2), 229-+.Elsevier BV. doi: 10.1016/j.cll.2007.03.001.

Wells, A., & Smith, B. (2006). Counterpoint developing a clinical pathology curriculum to meet current and future needs. CLINICAL CHEMISTRY, 52(6), 971-972.Oxford University Press (OUP). doi: 10.1373/clinchem.2006.070540.

Shao, H., Wang, A., Lauffenburger, D., & Wells, A. (2018). Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain. In INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 95, (pp. 73-84).Elsevier BV.Netherlands. doi: 10.1016/j.biocel.2017.12.014.