Afonso Silva

Rollin, I.Z., Papoti, D., Bishop, M., Szczupak, D., Corigliano, M.R., Hitchens, T.K., Zhang, B., Pell, S.K.A., Guretse, S.S., Dureux, A., Murai, T., Sukoff Rizzo, S.J., Klassen, L.M., Zeman, P., Gilbert, K.M., Menon, R.S., Lin, M.K., Everling, S., Silva, A.C., & Schaeffer, D.J. (2024). An Open Access Resource for Marmoset Neuroscientific Apparatus. In bioRxiv. doi: 10.1101/2024.11.12.623252.

Szczupak, D., Schaeffer, D.J., Tian, X., Choi, S.H., Fang-Cheng, Iack, P.M., Campos, V.P., Mayo, J.P., Patsch, J., Mitter, C., Haboosheh, A., Kwon, H.S., Vieira, M.A.C., Reich, D.S., Jacobson, S., Kasprian, G., Tovar-Moll, F., Lent, R., & Silva, A.C. (2024). Direct interhemispheric cortical communication via thalamic commissures: a new white matter pathway in the primate brain. Cereb Cortex, 34(1), bhad394.Oxford University Press (OUP). doi: 10.1093/cercor/bhad394.

Parks, T.V., Szuzupak, D., Choi, S.H., Alikaya, A., Mou, Y., Silva, A.C., & Schaeffer, D.J. (2023). Noninvasive disruption of the blood-brain barrier in the marmoset monkey. Commun Biol, 6(1), 806.Springer Nature. doi: 10.1038/s42003-023-05185-3.

Schaeffer, D.J., Gilbert, K.M., Bellyou, M., Silva, A.C., & Everling, S. (2022). Frontoparietal connectivity as a product of convergent evolution in rodents and primates: functional connectivity topologies in grey squirrels, rats, and marmosets. Commun Biol, 5(1), 986.Springer Nature. doi: 10.1038/s42003-022-03949-x.

Schaeffer, D.J., Klassen, L.M., Hori, Y., Tian, X., Szczupak, D., Yen, C.C.C., Cléry, J.C., Gilbert, K.M., Gati, J.S., Menon, R.S., Liu, C., Everling, S., & Silva, A.C. (2022). An open access resource for functional brain connectivity from fully awake marmosets. Neuroimage, 252, 119030.Elsevier. doi: 10.1016/j.neuroimage.2022.119030.

Szuzupak, D., Choi, S.H., Alikaya, A., Mou, Y., Silva, A., & Schaeffer, D. (2022). Non-invasive disruption of the blood-brain barrier in the marmoset monkey. Research Square Platform. doi: 10.21203/rs.3.rs-2252785/v1.

Tian, X., Chen, Y., Majka, P., Szczupak, D., Perl, Y.S., Yen, C.C.C., Tong, C., Feng, F., Jiang, H., Glen, D., Deco, G., Rosa, M.G.P., Silva, A.C., Liang, Z., & Liu, C. (2022). An integrated resource for functional and structural connectivity of the marmoset brain. Nat Commun, 13(1), 7416.Springer Nature. doi: 10.1038/s41467-022-35197-2.

Basso, M.A., Frey, S., Guerriero, K.A., Jarraya, B., Kastner, S., Koyano, K.W., Leopold, D.A., Murphy, K., Poirier, C., Pope, W., Silva, A.C., Tansey, G., & Uhrig, L. (2021). Using non-invasive neuroimaging to enhance the care, well-being and experimental outcomes of laboratory non-human primates (monkeys). Neuroimage, 228, 117667.Elsevier. doi: 10.1016/j.neuroimage.2020.117667.

Liu, C., Yen, C.C.C., Szczupak, D., Tian, X., Glen, D., & Silva, A.C. (2021). Marmoset Brain Mapping V3: Population multi-modal standard volumetric and surface-based templates. Neuroimage, 226, 117620.Elsevier. doi: 10.1016/j.neuroimage.2020.117620.

Majka, P., Bednarek, S., Chan, J.M., Jermakow, N., Liu, C., Saworska, G., Worthy, K.H., Silva, A.C., Wójcik, D.K., & Rosa, M.G.P. (2021). Histology-Based Average Template of the Marmoset Cortex With Probabilistic Localization of Cytoarchitectural Areas. Neuroimage, 226, 117625.Elsevier. doi: 10.1016/j.neuroimage.2020.117625.

Szczupak, D., Kossmann Ferraz, M., Gemal, L., Oliveira-Szejnfeld, P.S., Monteiro, M., Bramati, I., Vargas, F.R., IRC5 Consortium, Lent, R., Silva, A.C., & Tovar-Moll, F. (2021). Corpus callosum dysgenesis causes novel patterns of structural and functional brain connectivity. Brain Commun, 3(2), fcab057.Oxford University Press (OUP). doi: 10.1093/braincomms/fcab057.

Burns, M., & Silva, A.C. (2020). Current Topics in Research, Care, and Welfare of Common Marmosets. ILAR JOURNAL, 61(2-3), 107-109.Oxford University Press (OUP). doi: 10.1093/ilar/ilac001.

Kaneko, T., Takemura, H., Pestilli, F., Silva, A.C., Ye, F.Q., & Leopold, D.A. (2020). Spatial organization of occipital white matter tracts in the common marmoset. Brain Struct Funct, 225(4), 1313-1326.Springer Nature. doi: 10.1007/s00429-020-02060-3.

Lefeuvre, J.A., Guy, J.R., Luciano, N.J., Ha, S.K., Leibovitch, E., Santin, M.D., Silva, A.C., Jacobson, S., Lehéricy, S., Reich, D.S., & Sati, P. (2020). The spectrum of spinal cord lesions in a primate model of multiple sclerosis. Mult Scler, 26(3), 284-293.SAGE Publications. doi: 10.1177/1352458518822408.

Liu, C., Ye, F.Q., Newman, J.D., Szczupak, D., Tian, X., Yen, C.C.C., Majka, P., Glen, D., Rosa, M.G.P., Leopold, D.A., & Silva, A.C. (2020). A resource for the detailed 3D mapping of white matter pathways in the marmoset brain. Nat Neurosci, 23(2), 271-280.Springer Nature. doi: 10.1038/s41593-019-0575-0.

Majka, P., Bednarek, S., Chan, J.M., Jermakow, N., Liu, C., Saworska, G., Worthy, K.H., Silva, A.C., Wójcik, D.K., & Rosa, M.G.P. (2020). Histology-based average template of the marmoset cortex with probabilistic localization of cytoarchitectural areas. 2020.04.10.036632.Cold Spring Harbor Laboratory. doi: 10.1101/2020.04.10.036632.

Schaeffer, D.J., Liu, C., Silva, A.C., & Everling, S. (2020). Magnetic Resonance Imaging of Marmoset Monkeys. ILAR J, 61(2-3), 274-285.Oxford University Press (OUP). doi: 10.1093/ilar/ilaa029.

Szczupak, D., Liu, C., Yen, C.C.C., Choi, S.H., Meireles, F., Victorino, C., IRC5 Consortium, Richards, L., Lent, R., Silva, A.C., & Tovar-Moll, F. (2020). Long-distance aberrant heterotopic connectivity in a mouse strain with a high incidence of callosal anomalies. Neuroimage, 217, 116875.Elsevier. doi: 10.1016/j.neuroimage.2020.116875.

Choi, S.H., Mou, Y., & Silva, A.C. (2019). Cannabis and Cannabinoid Biology in Stroke. Stroke, 50(9), 2640-2645.Wolters Kluwer. doi: 10.1161/STROKEAHA.118.023587.

Lee, N.J., Ha, S.K., Sati, P., Absinta, M., Nair, G., Luciano, N.J., Leibovitch, E.C., Yen, C.C., Rouault, T.A., Silva, A.C., Jacobson, S., & Reich, D.S. (2019). Potential role of iron in repair of inflammatory demyelinating lesions. J Clin Invest, 129(10), 4365-4376.American Society for Clinical Investigation. doi: 10.1172/JCI126809.

Liu, C., Yen, C.C.C., Szczupak, D., Ye, F.Q., Leopold, D.A., & Silva, A.C. (2019). Anatomical and functional investigation of the marmoset default mode network. Nat Commun, 10(1), 1975.Springer Nature. doi: 10.1038/s41467-019-09813-7.

Park, J.E., & Silva, A.C. (2019). Generation of genetically engineered non-human primate models of brain function and neurological disorders. Am J Primatol, 81(2), e22931.Wiley. doi: 10.1002/ajp.22931.

Choi, S.H., Arai, A.L., Mou, Y., Kang, B., Yen, C.C.C., Hallenbeck, J., & Silva, A.C. (2018). Neuroprotective Effects of MAGL (Monoacylglycerol Lipase) Inhibitors in Experimental Ischemic Stroke. Stroke, 49(3), 718-726.Wolters Kluwer. doi: 10.1161/STROKEAHA.117.019664.

Hirano, Y., Yen, C.C., Liu, J.V., Mackel, J.B., Merkle, H., Nascimento, G.C., Stefanovic, B., & Silva, A.C. (2018). Investigation of the BOLD and CBV fMRI responses to somatosensory stimulation in awake marmosets (Callithrix jacchus). NMR Biomed, 31(3).Wiley. doi: 10.1002/nbm.3864.

Lee, N.J., Ha, S.K., Sati, P., Absinta, M., Luciano, N.J., Lefeuvre, J.A., Schindler, M.K., Leibovitch, E.C., Ryu, J.K., Petersen, M.A., Silva, A.C., Jacobson, S., Akassoglou, K., & Reich, D.S. (2018). Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination. Brain, 141(6), 1637-1649.Oxford University Press (OUP). doi: 10.1093/brain/awy082.

Leibovitch, E.C., Caruso, B., Ha, S.K., Schindler, M.K., Lee, N.J., Luciano, N.J., Billioux, B.J., Guy, J.R., Yen, C., Sati, P., Silva, A.C., Reich, D.S., & Jacobson, S. (2018). Herpes virus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(44), 11292-11297.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1811974115.

Liu, C., Ye, F.Q., Yen, C.C.C., Newman, J.D., Glen, D., Leopold, D.A., & Silva, A.C. (2018). A digital 3D atlas of the marmoset brain based on multi-modal MRI. Neuroimage, 169, 106-116.Elsevier. doi: 10.1016/j.neuroimage.2017.12.004.

Yen, C.C.C., Papoti, D., & Silva, A.C. (2018). Investigating the spatiotemporal characteristics of the deoxyhemoglobin-related and deoxyhemoglobin-unrelated functional hemodynamic response across cortical layers in awake marmosets. Neuroimage, 164, 121-130.Elsevier. doi: 10.1016/j.neuroimage.2017.03.005.

Papoti, D., Yen, C.C.C., Hung, C.C., Ciuchta, J., Leopold, D.A., & Silva, A.C. (2017). Design and implementation of embedded 8-channel receive-only arrays for whole-brain MRI and fMRI of conscious awake marmosets. Magn Reson Med, 78(1), 387-398.Wiley. doi: 10.1002/mrm.26339.

Silva, A.C. (2017). Anatomical and functional neuroimaging in awake, behaving marmosets. Dev Neurobiol, 77(3), 373-389.Wiley. doi: 10.1002/dneu.22456.

Toarmino, C.R., Yen, C.C.C., Papoti, D., Bock, N.A., Leopold, D.A., Miller, C.T., & Silva, A.C. (2017). Functional magnetic resonance imaging of auditory cortical fields in awake marmosets. Neuroimage, 162, 86-92.Elsevier. doi: 10.1016/j.neuroimage.2017.08.052.

Belcher, A.M., Yen, C.C.C., Notardonato, L., Ross, T.J., Volkow, N.D., Yang, Y., Stein, E.A., Silva, A.C., & Tomasi, D. (2016). Functional Connectivity Hubs and Networks in the Awake Marmoset Brain. Front Integr Neurosci, 10(MAR2016), 9.Frontiers. doi: 10.3389/fnint.2016.00009.

Guy, J.R., Sati, P., Leibovitch, E., Jacobson, S., Silva, A.C., & Reich, D.S. (2016). Custom fit 3D-printed brain holders for comparison of histology with MRI in marmosets. J Neurosci Methods, 257, 55-63.Elsevier. doi: 10.1016/j.jneumeth.2015.09.002.

Luciano, N.J., Sati, P., Nair, G., Guy, J.R., Ha, S.K., Absinta, M., Chiang, W.Y., Leibovitch, E.C., Jacobson, S., Silva, A.C., & Reich, D.S. (2016). Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning. J Vis Exp, 2016(118), 54780.MyJove. doi: 10.3791/54780.

Miller, C.T., Freiwald, W.A., Leopold, D.A., Mitchell, J.F., Silva, A.C., & Wang, X. (2016). Marmosets: A Neuroscientific Model of Human Social Behavior. Neuron, 90(2), 219-233.Elsevier. doi: 10.1016/j.neuron.2016.03.018.

Park, J.E., Zhang, X.F., Choi, S.H., Okahara, J., Sasaki, E., & Silva, A.C. (2016). Generation of transgenic marmosets expressing genetically encoded calcium indicators. Sci Rep, 6(1), 34931.Springer Nature. doi: 10.1038/srep34931.

Root, D.H., Wang, H.L., Liu, B., Barker, D.J., Mód, L., Szocsics, P., Silva, A.C., Maglóczky, Z., & Morales, M. (2016). Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans. Sci Rep, 6(1), 30615.Springer Nature. doi: 10.1038/srep30615.

Santisakultarm, T.P., Kersbergen, C.J., Bandy, D.K., Ide, D.C., Choi, S.H., & Silva, A.C. (2016). Two-photon imaging of cerebral hemodynamics and neural activity in awake and anesthetized marmosets. J Neurosci Methods, 271, 55-64.Elsevier. doi: 10.1016/j.jneumeth.2016.07.003.

Yu, X., He, Y., Wang, M., Merkle, H., Dodd, S.J., Silva, A.C., & Koretsky, A.P. (2016). Sensory and optogenetically driven single-vessel fMRI. Nat Methods, 13(4), 337-340.Springer Nature. doi: 10.1038/nmeth.3765.

Belmonte, J.C.I., Callaway, E.M., Caddick, S.J., Churchland, P., Feng, G., Homanics, G.E., Lee, K.F., Leopold, D.A., Miller, C.T., Mitchell, J.F., Mitalipov, S., Moutri, A.R., Movshon, J.A., Okano, H., Reynolds, J.H., Ringach, D.L., Sejnowski, T.J., Silva, A.C., Strick, P.L., Wu, J., & Zhang, F. (2015). Brains, Genes, and Primates (vol 86, pg 617, 2015). NEURON, 87(3), 671.Elsevier. doi: 10.1016/j.neuron.2015.07.021.

Hung, C.C., Yen, C.C., Ciuchta, J.L., Papoti, D., Bock, N.A., Leopold, D.A., & Silva, A.C. (2015). Functional MRI of visual responses in the awake, behaving marmoset. Neuroimage, 120, 1-11.Elsevier. doi: 10.1016/j.neuroimage.2015.06.090.

Hung, C.C., Yen, C.C., Ciuchta, J.L., Papoti, D., Bock, N.A., Leopold, D.A., & Silva, A.C. (2015). Functional mapping of face-selective regions in the extrastriate visual cortex of the marmoset. J Neurosci, 35(3), 1160-1172.Society for Neuroscience. doi: 10.1523/JNEUROSCI.2659-14.2015.

Izpisua Belmonte, J.C., Callaway, E.M., Caddick, S.J., Churchland, P., Feng, G., Homanics, G.E., Lee, K.F., Leopold, D.A., Miller, C.T., Mitchell, J.F., Mitalipov, S., Moutri, A.R., Movshon, J.A., Okano, H., Reynolds, J.H., Ringach, D., Sejnowski, T.J., Silva, A.C., Strick, P.L., Wu, J., & Zhang, F. (2015). Brains, genes, and primates. Neuron, 86(3), 617-631.Elsevier. doi: 10.1016/j.neuron.2015.03.021.

Reveley, C., Seth, A.K., Pierpaoli, C., Silva, A.C., Yu, D., Saunders, R.C., Leopold, D.A., & Ye, F.Q. (2015). Superficial white matter fiber systems impede detection of long-range cortical connections in diffusion MR tractography. Proc Natl Acad Sci U S A, 112(21), E2820-E2828.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1418198112.

Silva, A.C. (2015). Contrast Agents in Functional Magnetic Resonance Imaging. In Brain Mapping. 1, (pp. 37-46).Elsevier. doi: 10.1016/b978-0-12-397025-1.00004-x.

Gaitán, M.I., Maggi, P., Wohler, J., Leibovitch, E., Sati, P., Calandri, I.L., Merkle, H., Massacesi, L., Silva, A.C., Jacobson, S., & Reich, D.S. (2014). Perivenular brain lesions in a primate multiple sclerosis model at 7-tesla magnetic resonance imaging. Mult Scler, 20(1), 64-71.SAGE Publications. doi: 10.1177/1352458513492244.

Kang, B.T., Leoni, R.F., & Silva, A.C. (2014). Impaired CBF regulation and high CBF threshold contribute to the increased sensitivity of spontaneously hypertensive rats to cerebral ischemia. Neuroscience, 269, 223-231.Elsevier. doi: 10.1016/j.neuroscience.2014.03.031.

Maggi, P., Macri, S.M.C., Gaitán, M.I., Leibovitch, E., Wholer, J.E., Knight, H.L., Ellis, M., Wu, T., Silva, A.C., Massacesi, L., Jacobson, S., Westmoreland, S., & Reich, D.S. (2014). The formation of inflammatory demyelinated lesions in cerebral white matter. Ann Neurol, 76(4), 594-608.Wiley. doi: 10.1002/ana.24242.

Belcher, A.M., Yen, C.C., Stepp, H., Gu, H., Lu, H., Yang, Y., Silva, A.C., & Stein, E.A. (2013). Large-scale brain networks in the awake, truly resting marmoset monkey. J Neurosci, 33(42), 16796-16804.Society for Neuroscience. doi: 10.1523/JNEUROSCI.3146-13.2013.

Bock, N.A., & Silva, A.C. (2013). Visualizing Myeloarchitecture In Vivo with Magnetic Resonance Imaging in Common Marmosets (Callithrix jacchus). In Microstructural Parcellation of the Human Cerebral Cortex. (pp. 221-237).Springer Nature. doi: 10.1007/978-3-642-37824-9_8.

Leibovitch, E., Wohler, J.E., Macri, S.M.C., Motanic, K., Harberts, E., Gaitan, M.I., Maggi, P., Ellis, M., Westmoreland, S., Silva, A., Reich, D.S., & Jacobson, S. (2013). Novel Marmoset (Callithrix jacchus) Model of Human Herpes virus 6A and 6B Infections: Immunologic, Virologic and Radiologic Characterization. In Dittmer, D.P. (Ed.). PLoS Pathogens, 9(1), e1003138.Public Library of Science (PLoS). doi: 10.1371/journal.ppat.1003138.

Liu, J.V., Hirano, Y., Nascimento, G.C., Stefanovic, B., Leopold, D.A., & Silva, A.C. (2013). fMRI in the awake marmoset: somatosensory-evoked responses, functional connectivity, and comparison with propofol anesthesia. Neuroimage, 78, 186-195.Elsevier. doi: 10.1016/j.neuroimage.2013.03.038.

Mazzetto-Betti, K.C., Leoni, R.F., Pontes-Neto, O.M., Sturzbecher, M.J., Santos, A.C., Leite, J.P., Silva, A.C., & de Araujo, D.B. (2013). Quantification of BOLD fMRI parameters to infer cerebrovascular reactivity of the middle cerebral artery. J Magn Reson Imaging, 38(5), 1203-1209.Wiley. doi: 10.1002/jmri.23943.

McGuire, J.L., Bergstrom, H.C., Parker, C.C., Le, T., Morgan, M., Tang, H., Selwyn, R.G., Silva, A.C., Choi, K., Ursano, R.J., Palmer, A.A., & Johnson, L.R. (2013). Traits of fear resistance and susceptibility in an advanced intercross line. Eur J Neurosci, 38(9), 3314-3324.Wiley. doi: 10.1111/ejn.12337.

Papoti, D., Yen, C.C.C., Mackel, J.B., Merkle, H., & Silva, A.C. (2013). An embedded four-channel receive-only RF coil array for fMRI experiments of the somatosensory pathway in conscious awake marmosets. NMR Biomed, 26(11), 1395-1402.Wiley. doi: 10.1002/nbm.2965.

Sati, P., van Gelderen, P., Silva, A.C., Reich, D.S., Merkle, H., de Zwart, J.A., & Duyn, J.H. (2013). Micro-compartment specific T2* relaxation in the brain. Neuroimage, 77, 268-278.Elsevier. doi: 10.1016/j.neuroimage.2013.03.005.

Coeli, G.N.M., Tiengo, R.R., da Silva, A.C., Fernandes, J.O.M., da Silva, G.C., & da Silva, L.U.M.A. (2012). Neurocisticercose nodular calcificada com sinais de reativação. Radiologia Brasileira, 45(5), 291-293.FapUNIFESP (SciELO). doi: 10.1590/s0100-39842012000500012.

Kang, B.T., Leoni, R.F., Kim, D.E., & Silva, A.C. (2012). Phenylephrine-induced hypertension during transient middle cerebral artery occlusion alleviates ischemic brain injury in spontaneously hypertensive rats. Brain Res, 1477, 83-91.Elsevier. doi: 10.1016/j.brainres.2012.08.024.

Lee, J., Shmueli, K., Kang, B.T., Yao, B., Fukunaga, M., van Gelderen, P., Palumbo, S., Bosetti, F., Silva, A.C., & Duyn, J.H. (2012). The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain. Neuroimage, 59(4), 3967-3975.Elsevier. doi: 10.1016/j.neuroimage.2011.10.076.

Leoni, R.F., Mazzetto-Betti, K.C., Silva, A.C., Dos Santos, A.C., de Araujo, D.B., Leite, J.P., & Pontes-Neto, O.M. (2012). Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease Using MRI BOLD and ASL Techniques. Radiol Res Pract, 2012(1), 268483.Hindawi. doi: 10.1155/2012/268483.

Leoni, R.F., Paiva, F.F., Kang, B.T., Henning, E.C., Nascimento, G.C., Tannús, A., De Araújo, D.B., & Silva, A.C. (2012). Arterial spin labeling measurements of cerebral perfusion territories in experimental ischemic stroke. Transl Stroke Res, 3(1), 44-55.Springer Nature. doi: 10.1007/s12975-011-0115-z.

Malheiros, J.M., Polli, R.S., Paiva, F.F., Longo, B.M., Mello, L.E., Silva, A.C., Tannús, A., & Covolan, L. (2012). Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy. Epilepsia, 53(7), 1225-1232.Wiley. doi: 10.1111/j.1528-1167.2012.03521.x.

Sati, P., Silva, A.C., van Gelderen, P., Gaitan, M.I., Wohler, J.E., Jacobson, S., Duyn, J.H., & Reich, D.S. (2012). In vivo quantification of T₂ anisotropy in white matter fibers in marmoset monkeys. Neuroimage, 59(2), 979-985.Elsevier. doi: 10.1016/j.neuroimage.2011.08.064.

Silva, A.C. (2012). Using manganese-enhanced MRI to understand BOLD. Neuroimage, 62(2), 1009-1013.Elsevier. doi: 10.1016/j.neuroimage.2012.01.008.

Yu, X., Glen, D., Wang, S., Dodd, S., Hirano, Y., Saad, Z., Reynolds, R., Silva, A.C., & Koretsky, A.P. (2012). Direct imaging of macrovascular and microvascular contributions to BOLD fMRI in layers IV-V of the rat whisker-barrel cortex. Neuroimage, 59(2), 1451-1460.Elsevier. doi: 10.1016/j.neuroimage.2011.08.001.

Bock, N.A., Hashim, E., Kocharyan, A., & Silva, A.C. (2011). Visualizing myeloarchitecture with magnetic resonance imaging in primates. Ann N Y Acad Sci, 1225 Suppl 1(Suppl 1), E171-E181.Wiley. doi: 10.1111/j.1749-6632.2011.06000.x.

Hirano, Y., Stefanovic, B., & Silva, A.C. (2011). Spatiotemporal evolution of the functional magnetic resonance imaging response to ultrashort stimuli. J Neurosci, 31(4), 1440-1447.Society for Neuroscience. doi: 10.1523/JNEUROSCI.3986-10.2011.

Lee, J., van Gelderen, P., Kuo, L.W., Merkle, H., Silva, A.C., & Duyn, J.H. (2011). T2*-based fiber orientation mapping. Neuroimage, 57(1), 225-234.Elsevier. doi: 10.1016/j.neuroimage.2011.04.026.

Leoni, R.F., Paiva, F.F., Henning, E.C., Nascimento, G.C., Tannús, A., de Araujo, D.B., & Silva, A.C. (2011). Magnetic resonance imaging quantification of regional cerebral blood flow and cerebrovascular reactivity to carbon dioxide in normotensive and hypertensive rats. Neuroimage, 58(1), 75-81.Elsevier. doi: 10.1016/j.neuroimage.2011.06.030.

Liu, J.V., Bock, N.A., & Silva, A.C. (2011). Rapid high-resolution three-dimensional mapping of T1 and age-dependent variations in the non-human primate brain using magnetization-prepared rapid gradient-echo (MPRAGE) sequence. Neuroimage, 56(3), 1154-1163.Elsevier. doi: 10.1016/j.neuroimage.2011.02.075.

Piknova, B., Kocharyan, A., Schechter, A.N., & Silva, A.C. (2011). The role of nitrite in neurovascular coupling. Brain Res, 1407, 62-68.Elsevier. doi: 10.1016/j.brainres.2011.06.045.

Silva, A.C., Liu, J.V., Hirano, Y., Leoni, R.F., Merkle, H., Mackel, J.B., Zhang, X.F., Nascimento, G.C., & Stefanovic, B. (2011). Longitudinal functional magnetic resonance imaging in animal models. 711, 281-302.Springer Nature. doi: 10.1007/978-1-61737-992-5_14.

Aid, S., Silva, A.C., Candelario-Jalil, E., Choi, S.H., Rosenberg, G.A., & Bosetti, F. (2010). Cyclooxygenase-1 and -2 differentially modulate lipopolysaccharide-induced blood-brain barrier disruption through matrix metalloproteinase activity. J Cereb Blood Flow Metab, 30(2), 370-380.SAGE Publications. doi: 10.1038/jcbfm.2009.223.

Hu, T.C.C., Waghorn, B., Yanasak, N., & Silva, A.C. (2010). Manganese-Enhanced Magnetic Resonance Imaging: Applications to Preclinical Research*. In Comprehensive Toxicology. 6, (pp. 199-219).Elsevier. doi: 10.1016/b978-0-08-046884-6.00710-7.

Kawai, Y., Aoki, I., Umeda, M., Higuchi, T., Kershaw, J., Higuchi, M., Silva, A.C., & Tanaka, C. (2010). In vivo visualization of reactive gliosis using manganese-enhanced magnetic resonance imaging. Neuroimage, 49(4), 3122-3131.Elsevier. doi: 10.1016/j.neuroimage.2009.11.005.

Lee, J., Hirano, Y., Fukunaga, M., Silva, A.C., & Duyn, J.H. (2010). On the contribution of deoxy-hemoglobin to MRI gray-white matter phase contrast at high field. Neuroimage, 49(1), 193-198.Elsevier. doi: 10.1016/j.neuroimage.2009.07.017.

Lee, J., Shmueli, K., Fukunaga, M., van Gelderen, P., Merkle, H., Silva, A.C., & Duyn, J.H. (2010). Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure (vol 107, pg 5130, 2010). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(18), 8498.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1003440107.

Lee, J., Shmueli, K., Fukunaga, M., van Gelderen, P., Merkle, H., Silva, A.C., & Duyn, J.H. (2010). Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure. Proc Natl Acad Sci U S A, 107(11), 5130-5135.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0910222107.

Lu, H., Leoni, R., Silva, A.C., Stein, E.A., & Yang, Y. (2010). High-field continuous arterial spin labeling with long labeling duration: reduced confounds from blood transit time and postlabeling delay. Magn Reson Med, 64(6), 1557-1566.Wiley. doi: 10.1002/mrm.22576.

Mazzetto-Betti, K.C., Leoni, R.F., Pontes-Neto, O.M., Santos, A.C., Leite, J.P., Silva, A.C., & de Araujo, D.B. (2010). The stability of the blood oxygenation level-dependent functional MRI response to motor tasks is altered in patients with chronic ischemic stroke. Stroke, 41(9), 1921-1926.Wolters Kluwer. doi: 10.1161/STROKEAHA.110.590471.

Munasinghe, J.P., Banerjee, M., Acosta, M.T., Banks, M., Heffer, A., Silva, A.C., Koretsky, A., & Theodore, W.H. (2010). Arterial spin labeling demonstrates that focal amygdalar glutamatergic agonist infusion leads to rapid diffuse cerebral activation. Acta Neurol Scand, 121(3), 209-216.Hindawi. doi: 10.1111/j.1600-0404.2009.01188.x.

Bock, N.A., Kocharyan, A., & Silva, A.C. (2009). Manganese-enhanced MRI visualizes V1 in the non-human primate visual cortex. NMR Biomed, 22(7), 730-736.Wiley. doi: 10.1002/nbm.1384.

Bock, N.A., Kocharyan, A., Liu, J.V., & Silva, A.C. (2009). Visualizing the entire cortical myelination pattern in marmosets with magnetic resonance imaging. J Neurosci Methods, 185(1), 15-22.Elsevier. doi: 10.1016/j.jneumeth.2009.08.022.

Chuang, K.H., Lee, J.H., Silva, A.C., Belluscio, L., & Koretsky, A.P. (2009). Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli. Neuroimage, 44(2), 363-372.Elsevier. doi: 10.1016/j.neuroimage.2008.08.046.

Koretsky, A.P., Talagala, S.L., & Silva, A.C. (2009). Detection of regional blood flow using arterial spin labeling. In Clinical MR Neuroimaging. (pp. 94-112).Cambridge University Press (CUP). doi: 10.1017/cbo9781139193481.011.

Newman, J.D., Kenkel, W.M., Aronoff, E.C., Bock, N.A., Zametkin, M.R., & Silva, A.C. (2009). A combined histological and MRI brain atlas of the common marmoset monkey, Callithrix jacchus. Brain Res Rev, 62(1), 1-18.Elsevier. doi: 10.1016/j.brainresrev.2009.09.001.

Silva, A.C., & Paiva, F.F. (2009). Dynamic magnetic resonance imaging of cerebral blood flow using arterial spin labeling. 489, 277-295.Springer Nature. doi: 10.1007/978-1-59745-543-5_13.

Tucciarone, J., Chuang, K.H., Dodd, S.J., Silva, A., Pelled, G., & Koretsky, A.P. (2009). Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI. Neuroimage, 44(3), 923-931.Elsevier. doi: 10.1016/j.neuroimage.2008.07.036.

Bock, N.A., Paiva, F.F., & Silva, A.C. (2008). Fractionated manganese-enhanced MRI. NMR Biomed, 21(5), 473-478.Wiley. doi: 10.1002/nbm.1211.

Bock, N.A., Paiva, F.F., Nascimento, G.C., Newman, J.D., & Silva, A.C. (2008). Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI. Brain Res, 1198, 160-170.Elsevier. doi: 10.1016/j.brainres.2007.12.065.

Goloshevsky, A.G., Silva, A.C., Dodd, S.J., & Koretsky, A.P. (2008). BOLD fMRI and somatosensory evoked potentials are well correlated over a broad range of frequency content of somatosensory stimulation of the rat forepaw. Brain Res, 1195, 67-76.Elsevier. doi: 10.1016/j.brainres.2007.11.036.

Paiva, F.F., Tannus, A., Talagala, S.L., & Silva, A.C. (2008). Arterial spin labeling of cerebral perfusion territories using a separate labeling coil. JOURNAL OF MAGNETIC RESONANCE IMAGING, 27(5), 970-977.Wiley. doi: 10.1002/jmri.21320.

Silva, A.C., & Bock, N.A. (2008). Manganese-enhanced MRI: an exceptional tool in translational neuroimaging. Schizophr Bull, 34(4), 595-604.Oxford University Press (OUP). doi: 10.1093/schbul/sbn056.

Silva, A.C., & Stefanovic, B. (2008). Animal Models in Functional Magnetic Resonance Imaging. In Sourcebook of Models for Biomedical Research. (pp. 483-498).Springer Nature. doi: 10.1007/978-1-59745-285-4_51.

Silva, A.C., Lee, J.H., Wu, C.W.H., Tucciarone, J., Pelled, G., Aoki, I., & Koretsky, A.P. (2008). Detection of cortical laminar architecture using manganese-enhanced MRI. J Neurosci Methods, 167(2), 246-257.Elsevier. doi: 10.1016/j.jneumeth.2007.08.020.

Silva, A.C.D., Reis, B.B., Ricci Junior, J.E.R., Fernandes, F.S., Corrêa, J.F., & Schatzmayr, H.G. (2008). [Human infection by the cowpox virus in the microregion of Itajubá, state of Minas Gerais: case report]. Rev Soc Bras Med Trop, 41(5), 507-511.FapUNIFESP (SciELO). doi: 10.1590/s0037-86822008000500015.

Stefanovic, B., Hutchinson, E., Yakovleva, V., Schram, V., Russell, J.T., Belluscio, L., Koretsky, A.P., & Silva, A.C. (2008). Functional reactivity of cerebral capillaries. J Cereb Blood Flow Metab, 28(5), 961-972.SAGE Publications. doi: 10.1038/sj.jcbfm.9600590.

Bock, N.A., & Silva, A.C. (2007). Manganese: a unique neuroimaging contrast agent. Future Neurology, 2(3), 297-305.Taylor & Francis. doi: 10.2217/14796708.2.3.297.

de Sousa, P.L., de Souza, S.L., Silva, A.C., de Souza, R.E., & de Castro, R.M. (2007). Manganese-enhanced magnetic resonance imaging (MEMRI) of rat brain after systemic administration of MnCl2: changes in T1 relaxation times during postnatal development. J Magn Reson Imaging, 25(1), 32-38.Wiley. doi: 10.1002/jmri.20792.

Paiva, F.F., Tannús, A., & Silva, A.C. (2007). Measurement of cerebral perfusion territories using arterial spin labelling. NMR Biomed, 20(7), 633-642.Wiley. doi: 10.1002/nbm.1177.

Silva, A.C., Koretsky, A.P., & Duyn, J.H. (2007). Functional MRI impulse response for BOLD and CBV contrast in rat somatosensory cortex. Magn Reson Med, 57(6), 1110-1118.Wiley. doi: 10.1002/mrm.21246.

Stefanovic, B., Schwindt, W., Hoehn, M., & Silva, A.C. (2007). Functional uncoupling of hemodynamic from neuronal response by inhibition of neuronal nitric oxide synthase. J Cereb Blood Flow Metab, 27(4), 741-754.SAGE Publications. doi: 10.1038/sj.jcbfm.9600377.

Aoki, I., Takahashi, Y., Chuang, K.H., Silva, A.C., Igarashi, T., Tanaka, C., Childs, R.W., & Koretsky, A.P. (2006). Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride. NMR Biomed, 19(1), 50-59.Wiley. doi: 10.1002/nbm.1000.

Gsell, W., Burke, M., Wiedermann, D., Bonvento, G., Silva, A.C., Dauphin, F., Bührle, C., Hoehn, M., & Schwindt, W. (2006). Differential effects of NMDA and AMPA glutamate receptors on functional magnetic resonance imaging signals and evoked neuronal activity during forepaw stimulation of the rat. J Neurosci, 26(33), 8409-8416.Society for Neuroscience. doi: 10.1523/JNEUROSCI.4615-05.2006.

Hutchinson, E.B., Stefanovic, B., Koretsky, A.P., & Silva, A.C. (2006). Spatial flow-volume dissociation of the cerebral microcirculatory response to mild hypercapnia. Neuroimage, 32(2), 520-530.Elsevier. doi: 10.1016/j.neuroimage.2006.03.033.

Keilholz, S.D., Silva, A.C., Raman, M., Merkle, H., & Koretsky, A.P. (2006). BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system. Magn Reson Med, 55(2), 316-324.Wiley. doi: 10.1002/mrm.20744.

Petridou, N., Plenz, D., Silva, A.C., Loew, M., Bodurka, J., & Bandettini, P.A. (2006). Direct magnetic resonance detection of neuronal electrical activity. Proc Natl Acad Sci U S A, 103(43), 16015-16020.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0603219103.

Stefanovic, B., Bosetti, F., & Silva, A.C. (2006). Modulatory role of cyclooxygenase-2 in cerebrovascular coupling. Neuroimage, 32(1), 23-32.Elsevier. doi: 10.1016/j.neuroimage.2006.03.014.

Chen, Z., Silva, A.C., Yang, J., & Shen, J. (2005). Elevated endogenous GABA level correlates with decreased fMRI signals in the rat brain during acute inhibition of GABA transaminase. J Neurosci Res, 79(3), 383-391.Wiley. doi: 10.1002/jnr.20364.

de Zwart, J.A., Silva, A.C., van Gelderen, P., Kellman, P., Fukunaga, M., Chu, R., Koretsky, A.P., Frank, J.A., & Duyn, J.H. (2005). Temporal dynamics of the BOLD fMRI impulse response. Neuroimage, 24(3), 667-677.Elsevier. doi: 10.1016/j.neuroimage.2004.09.013.

Lee, J.H., Silva, A.C., Merkle, H., & Koretsky, A.P. (2005). Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast. Magn Reson Med, 53(3), 640-648.Wiley. doi: 10.1002/mrm.20368.

Aoki, I., Wu, Y.J.L., Silva, A.C., Lynch, R.M., & Koretsky, A.P. (2004). In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI. Neuroimage, 22(3), 1046-1059.Elsevier. doi: 10.1016/j.neuroimage.2004.03.031.

Keilholz, S.D., Silva, A.C., Raman, M., Merkle, H., & Koretsky, A.P. (2004). Functional MRI of the rodent somatosensory pathway using multislice echo planar imaging. Magn Reson Med, 52(1), 89-99.Wiley. doi: 10.1002/mrm.20114.

Koretsky, A.P., & Silva, A.C. (2004). Manganese-enhanced magnetic resonance imaging (MEMRI). NMR Biomed, 17(8), 527-531.Wiley. doi: 10.1002/nbm.940.

Silva, A.C., Lee, J.H., Aoki, I., & Koretsky, A.P. (2004). Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations. NMR Biomed, 17(8), 532-543.Wiley. doi: 10.1002/nbm.945.

Grabill, C., Silva, A.C., Smith, S.S., Koretsky, A.P., & Rouault, T.A. (2003). MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice. Brain Res, 971(1), 95-106.Elsevier. doi: 10.1016/s0006-8993(03)02366-7.

Hinds, K.A., Hill, J.M., Shapiro, E.M., Laukkanen, M.O., Silva, A.C., Combs, C.A., Varney, T.R., Balaban, R.S., Koretsky, A.P., & Dunbar, C.E. (2003). Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood, 102(3), 867-872.American Society of Hematology. doi: 10.1182/blood-2002-12-3669.

Silva, A.C., & Kim, S.G. (2003). Perfusion-based functional magnetic resonance imaging. CONCEPTS IN MAGNETIC RESONANCE PART A, 16A(1), 16-27.Wiley. doi: 10.1002/cmr.a.10050.

Silva, A.C., & Merkle, H. (2003). Hardware considerations for functional magnetic resonance imaging. CONCEPTS IN MAGNETIC RESONANCE PART A, 16A(1), 35-49.Wiley. doi: 10.1002/cmr.a.10052.

Aoki, I., Tanaka, C., Takegami, T., Ebisu, T., Umeda, M., Fukunaga, M., Fukuda, K., Silva, A.C., Koretsky, A.P., & Naruse, S. (2002). Dynamic activity-induced manganese-dependent contrast magnetic resonance imaging (DAIM MRI). Magn Reson Med, 48(6), 927-933.Wiley. doi: 10.1002/mrm.10320.

Dodd, S.J., Williams, D.S., Olson, C., Silva, A.C., Koretsky, A.P., & Ho, C. (2002). An open transverse z-gradient coil design for magnetic resonance imaging. REVIEW OF SCIENTIFIC INSTRUMENTS, 73(5), 2208-2210.AIP Publishing. doi: 10.1063/1.1470709.

Lee, S.P., Silva, A.C., & Kim, S.G. (2002). Comparison of diffusion-weighted high-resolution CBF and spin-echo BOLD fMRI at 9.4 T. Magn Reson Med, 47(4), 736-741.Wiley. doi: 10.1002/mrm.10117.

Silva, A.C., & Koretsky, A.P. (2002). Laminar specificity of functional MRI onset times during somatosensory stimulation in rat. Proc Natl Acad Sci U S A, 99(23), 15182-15187.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.222561899.

Barbier, E.L., Silva, A.C., Kim, S.G., & Koretsky, A.P. (2001). Perfusion imaging using dynamic arterial spin labeling (DASL). Magn Reson Med, 45(6), 1021-1029.Wiley. doi: 10.1002/mrm.1136.

Duong, T.Q., Silva, A.C., Lee, S.P., & Kim, S.G. (2000). Functional MRI of calcium-dependent synaptic activity: cross correlation with CBF and BOLD measurements. Magn Reson Med, 43(3), 383-392.Wiley. doi: 10.1002/(sici)1522-2594(200003)43:3<383::aid-mrm10>3.0.co;2-q.

Silva, A.C., Kim, S.G., & Garwood, M. (2000). Imaging blood flow in brain tumors using arterial spin labeling. Magn Reson Med, 44(2), 169-173.Wiley. doi: 10.1002/1522-2594(200008)44:2<169::aid-mrm1>3.0.co;2-u.

Silva, A.C., Lee, S.P., Iadecola, C., & Kim, S.G. (2000). Early temporal characteristics of cerebral blood flow and deoxyhemoglobin changes during somatosensory stimulation. J Cereb Blood Flow Metab, 20(1), 201-206.SAGE Publications. doi: 10.1097/00004647-200001000-00025.

Barbier, E.L., Silva, A.C., Kim, H.J., Williams, D.S., & Koretsky, A.P. (1999). Perfusion analysis using dynamic arterial spin labeling (DASL). Magn Reson Med, 41(2), 299-308.Wiley. doi: 10.1002/(sici)1522-2594(199902)41:2<299::aid-mrm13>3.0.co;2-r.

Barbier, E.L., Silva, A.C., Kim, H.J., Williams, D.S., & Koretsky, A.P. (1999). Perfusion analysis using dynamic arterial spin labeling (DASL). Magnetic Resonance in Medicine, 41(2), 299-308. doi: 10.1002/(SICI)1522-2594(199902)41:2<299::AID-MRM13>3.0.CO;2-R.

Lee, S.P., Silva, A.C., Ugurbil, K., & Kim, S.G. (1999). Diffusion-weighted spin-echo fMRI at 9.4 T: microvascular/tissue contribution to BOLD signal changes. Magn Reson Med, 42(5), 919-928.Wiley. doi: 10.1002/(sici)1522-2594(199911)42:5<919::aid-mrm12>3.0.co;2-8.

Silva, A.C., & Kim, S.G. (1999). Pseudo-continuous arterial spin labeling technique for measuring CBF dynamics with high temporal resolution. Magn Reson Med, 42(3), 425-429.Wiley. doi: 10.1002/(sici)1522-2594(199909)42:3<425::aid-mrm3>3.0.co;2-s.

Silva, A.C., Lee, S.P., Yang, G., Iadecola, C., & Kim, S.G. (1999). Simultaneous blood oxygenation level-dependent and cerebral blood flow functional magnetic resonance imaging during forepaw stimulation in the rat. J Cereb Blood Flow Metab, 19(8), 871-879.SAGE Publications. doi: 10.1097/00004647-199908000-00006.

Forman, S.D., Silva, A.C., Dedousis, N., Barbier, E.L., Fernstrom, J.D., & Koretsky, A.P. (1998). Simultaneous glutamate and perfusion fMRI responses to regional brain stimulation. J Cereb Blood Flow Metab, 18(10), 1064-1070.SAGE Publications. doi: 10.1097/00004647-199810000-00002.

Pautler, R.G., Silva, A.C., & Koretsky, A.P. (1998). In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging. Magn Reson Med, 40(5), 740-748.Wiley. doi: 10.1002/mrm.1910400515.

Silva, A.C., Barbier, E.L., Lowe, I.J., & Koretsky, A.P. (1998). Radial echo-planar imaging. J Magn Reson, 135(1), 242-247.Elsevier. doi: 10.1006/jmre.1998.1547.

Silva, A.C., Williams, D.S., & Koretsky, A.P. (1997). Evidence for the exchange of arterial spin-labeled water with tissue water in rat brain from diffusion-sensitized measurements of perfusion. Magn Reson Med, 38(2), 232-237.Wiley. doi: 10.1002/mrm.1910380211.

Silva, A.C., Zhang, W., Williams, D.S., & Koretsky, A.P. (1997). Estimation of water extraction fractions in rat brain using magnetic resonance measurement of perfusion with arterial spin labeling. Magn Reson Med, 37(1), 58-68.Wiley. doi: 10.1002/mrm.1910370110.

Silva, A.C., Zhang, W., Williams, D.S., & Koretsky, A.P. (1995). Multi-slice MRI of rat brain perfusion during amphetamine stimulation using arterial spin labeling. Magn Reson Med, 33(2), 209-214.Wiley. doi: 10.1002/mrm.1910330210.

Zhang, W., Silva, A.C., Williams, D.S., & Koretsky, A.P. (1995). NMR measurement of perfusion using arterial spin labeling without saturation of macromolecular spins. Magn Reson Med, 33(3), 370-376.Wiley. doi: 10.1002/mrm.1910330310.

Detre, J.A., Zhang, W., Roberts, D.A., Silva, A.C., Williams, D.S., Grandis, D.J., Koretsky, A.P., & Leigh, J.S. (1994). Tissue specific perfusion imaging using arterial spin labeling. NMR Biomed, 7(1-2), 75-82.Wiley. doi: 10.1002/nbm.1940070112.