Project 1. Reduction of Inflammation at the Electrode Tissue Interface
Chronic interfacing with the nervous system is often impeded by the foreign body response to the implant. Through altering the material properties of the probes and the surface chemistry, we hope to increase the long-term viability of central and peripheral neural implants. My work focuses on new methods of probe surface functionalization, through the attachment of antioxidant catalysts and proteins, drug delivery, and elastomeric electrodes for nervous interfacing.
Project 2. Novel Dopants for conducting polymers
Electrochemical drug delivery possesses outstanding spatial and temporal control of release, but is plagued by issues of drug compatibility and release quantity. I have developed a nanoparticle doped conducting polymer, greatly increasing the quantity of loaded compounds and allowing for facile loading of positively charged and electroactive compounds such as doxorubicin and melatonin. The films further possess outstanding electrochemical properties and stability under stimulation.
Yang Shen; Bin Cao; Noah Snyder; Kevin M. Woeppel; James Eles; Xinyan Cui, ROS Responsive Resveratrol Delivery from LDLR Peptide Conjugated PLA-coated Mesoporous Silica Nanoparticles Across the Blood-Brain Barrier, Journal of Nanobiotechnology, 2018, 16:13
K Woeppel, Q Yang, XT Cui, “Recent Advances in Neural Electrode-Tissue Interface”, Current Opinion in Biomedical Engineering, December 2017,Vol 4, Pages 21-31
Kevin M. Woeppel, Xin Zheng, X. Tracy Cui, Enhancing Surface Immobilization of Bioactive Molecule via Silica Nanoparticle Base Coating, Journal of Materials Chemistry B, 2018, 10.1039/C8TB00408K
X. Zheng, K. M. Woeppel, A. Y. Griffith, E. Chang, M. J. Looker, L. E. Fisher, B. J. Clapsaddle, X. T. Cui, Soft Conducting Elastomer for Peripheral Nerve Interface Adv. Healthcare Mater. 2019, 1801311
Bingchen Wu, Bin Cao, Ian M. Taylor, Kevin Woeppel, Xinyan Tracy Cui, Facile Synthesis of a 3,4-Ethylene-Dioxythiophene (EDOT) Derivative for Ease of Bio-functionalization of the Conducting Polymer PEDOT. Frontiers in Chemistry. 2019
X Sally Zheng*, Noah R Snyder*, Kevin Woeppel*, Jenna Hanner, Xia Li, James Eles, Christi L Kolarcik, X Tracy Cui, A Superoxide Scavenging Coating for Improving Tissue Response to Neural Implants. Acta Biomateriala. 2019 [Link]
Kevin M. Woeppel, X. Sally Zheng, Zachary M. Schulte, Nathaniel L. Rosi, Xinyan Tracy Cui, Nanoparticle Doped PEDOT for Enhanced Electrode Coatings and Drug Delivery. Adv. Healthcare Mater. 2019 [Link]
Elisa Castagnola, Kevin Woeppel, Asiyeh Golabchi, Moriah McGuier, Neharika Chodapaneedi, Julian Metro, I Mitch Taylor, Xinyan Tracy Cui, Electrochemical Detection of Exogenously Administered Melatonin in the Brain, Analyst, 2020, DOI: 10.1039/D0AN00051E
Asiyeh Golabchi, Kevin M. Woeppel, Xia Li, Carl F. Lagenaur and X. Tracy Cui, Neuroadhesive protein coating improves the chronic performance of neuroelectronics in mouse brain, Biosensors and Bioelectronics 2020.
K Woeppel, S Zheng, B Clapsaddle, M Looker, L Fisher, T Cui. (2017) “Conductive Elastomeric Electrodes for Interfacing with Peripheral Nervous System”, Materials Research Society Oral Presentation
K Woeppel, S Zheng, T Cui, (2019) "Nanoparticle Dopants Enhance Electrically Controlled Drug Release from Conducting Polymer Coatings", Society for Biomaterials Oral Presentation
K Woeppel, T Cui (2019) "Increasing Stability and Tissue Integration of Biomimetic Neural Electrodes by Nanoparticle Coatings" BMES Oral Presentation
K Woeppel, T Cui, (2017) “Nanoparticle texturization for increased efficacy of surface modification” Biomaterials Day, University of Michigan Poster Presentation
K Woeppel, T Cui, (2018) "Nanoparticle Crosslinkers: Increasing the Efficacy of Surface Modification for Neural Implants", Society for Biomaterials Poster Presentation
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