headshot of Samira Kiani

Samira Kiani

Associate Professor

overview

We are interested in building and examine genetic circuits that can control the CRISPR gene editing and epigenome editing tools with focus on application for immunotherapy, liver diseases and pain management. Please visit www.kianilab.com

We also are actively involved in developing programs to engage public in conversations about science and technology by employing the power of fimmaking. Please visit www.tomorrow.life

about

Delgado, E., & Kiani, S. (2020). A CRISPR Odyssey into Cancer Immunotherapy. CRISPR JOURNAL, 3(2), 73-75.Mary Ann Liebert. doi: 10.1089/crispr.2020.29090.ede.

Ferdosi, S.R., Ewaisha, R., Moghadam, F., Krishna, S., Park, J.G., Ebrahimkhani, M.R., Kiani, S., & Anderson, K.S. (2019). Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes. Nature Communications, 10(1), 1842.Springer Nature. doi: 10.1038/s41467-019-09693-x.

Pineda, M., Lear, A., Collins, J.P., & Kiani, S. (2019). Safe CRISPR: Challenges and Possible Solutions. Trends in Biotechnology, 37(4), 389-401.Elsevier. doi: 10.1016/j.tibtech.2018.09.010.

Yeo, N.C., Chavez, A., Lance-Byrne, A., Chan, Y., Menn, D., Milanova, D., Kuo, C.C., Guo, X., Sharma, S., Tung, A., Cecchi, R.J., Tuttle, M., Pradhan, S., Lim, E.T., Davidsohn, N., Ebrahimkhani, M.R., Collins, J.J., Lewis, N.E., Kiani, S., & Church, G.M. (2018). An enhanced CRISPR repressor for targeted mammalian gene regulation. Nature Methods, 15(8), 611-616.Springer Nature. doi: 10.1038/s41592-018-0048-5.

Kiani, S., Chavez, A., Tuttle, M., Hall, R.N., Chari, R., Ter-Ovanesyan, D., Qian, J., Pruitt, B.W., Beal, J., Vora, S., Buchthal, J., Kowal, E.J.K., Ebrahimkhani, M.R., Collins, J.J., Weiss, R., & Church, G. (2015). Cas9 gRNA engineering for genome editing, activation and repression. Nature Methods, 12(11), 1051-1054.Springer Nature. doi: 10.1038/nmeth.3580.