headshot of Jason Becker

Jason Becker

Associate Professor
Associate Professor of Medicine
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overview

Our laboratory studies the molecular mechanisms regulating genetic and acquired cardiomyopathies to identify novel methods to prevent heart failure and sudden death. We utilize a variety of experimental systems which include animal model organisms, human induced pluripotent stem cell cardiomyocytes (iPS-CM) and human tissue samples.

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Hall, E.J., Pal, S., Glennon, M.S., Shridhar, P., Satterfield, S.L., Weber, B., Zhang, Q., Salama, G., Lal, H., & Becker, J.R. (2022). Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling. Cardiovasc Res, 118(9), 2124-2138.Oxford University Press (OUP). doi: 10.1093/cvr/cvab257.

de Feria, A.E., Kott, A.E., & Becker, J.R. (2021). Sarcomere mutation negative hypertrophic cardiomyopathy is associated with ageing and obesity. Open Heart, 8(1), e001560.BMJ. doi: 10.1136/openhrt-2020-001560.

Pal, S., Nixon, B.R., Glennon, M.S., Shridhar, P., Satterfield, S.L., Su, Y.R., & Becker, J.R. (2021). Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling. J Am Heart Assoc, 10(15), e021768.Wolters Kluwer. doi: 10.1161/JAHA.121.021768.

Nixon, B.R., Sebag, S.C., Glennon, M.S., Hall, E.J., Kounlavong, E.S., Freeman, M.L., & Becker, J.R. (2019). Nuclear localized Raf1 isoform alters DNA-dependent protein kinase activity and the DNA damage response. FASEB J, 33(1), 1138-1150.Wiley. doi: 10.1096/fj.201800336R.

Nixon, B.R., Williams, A.F., Glennon, M.S., de Feria, A.E., Sebag, S.C., Baldwin, H.S., & Becker, J.R. (2017). Alterations in sarcomere function modify the hyperplastic to hypertrophic transition phase of mammalian cardiomyocyte development. JCI Insight, 2(4), e90656.American Society for Clinical Investigation. doi: 10.1172/jci.insight.90656.

Becker, J.R., Robinson, T.Y., Sachidanandan, C., Kelly, A.E., Coy, S., Peterson, R.T., & MacRae, C.A. (2012). In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. Cardiovasc Res, 93(3), 463-470.Oxford University Press (OUP). doi: 10.1093/cvr/cvr350.