headshot of Jason Becker

Jason Becker

Associate Professor
Associate Professor of Medicine
Website Bioengineering Department

overview

Our laboratory studies the molecular mechanisms regulating genetic and acquired cardiomyopathies to identify novel methods to prevent heart failure and sudden death. We utilize a variety of experimental systems which include animal model organisms, human induced pluripotent stem cell cardiomyocytes (iPS-CM) and human tissue samples.

about

Hall, E.J., Pal, S., Glennon, M.S., Shridhar, P., Satterfield, S.L., Weber, B., Zhang, Q., Salama, G., Lal, H., & Becker, J.R. (2022). Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling. CARDIOVASCULAR RESEARCH, 118(9), 2124-2138.Oxford University Press (OUP). doi: 10.1093/cvr/cvab257.

de Feria, A.E., Kott, A.E., & Becker, J.R. (2021). Sarcomere mutation negative hypertrophic cardiomyopathy is associated with ageing and obesity. Open Heart, 8(1), e001560.BMJ. doi: 10.1136/openhrt-2020-001560.

Pal, S., Nixon, B.R., Glennon, M.S., Shridhar, P., Satterfield, S.L., Su, Y.R., & Becker, J.R. (2021). Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(15), e021768.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/JAHA.121.021768.

Nixon, B.R., Sebag, S.C., Glennon, M.S., Hall, E.J., Kounlavong, E.S., Freeman, M.L., & Becker, J.R. (2019). Nuclear localized Raf1 isoform alters DNA‚Äźdependent protein kinase activity and the DNA damage response. The FASEB Journal, 33(1), 1138-1150.Wiley. doi: 10.1096/fj.201800336r.

Nixon, B.R., Williams, A.F., Glennon, M.S., de Feria, A.E., Sebag, S.C., Baldwin, H.S., & Becker, J.R. (2017). Alterations in sarcomere function modify the hyperplastic to hypertrophic transition phase of mammalian cardiomyocyte development. JCI Insight, 2(4).American Society for Clinical Investigation. doi: 10.1172/jci.insight.90656.

Becker, J.R., Robinson, T.Y., Sachidanandan, C., Kelly, A.E., Coy, S., Peterson, R.T., & MacRae, C.A. (2012). In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. Cardiovascular Research, 93(3), 463-470.Oxford University Press (OUP). doi: 10.1093/cvr/cvr350.