headshot

Hang Lin

Assistant Professor
Lin Lab Bioengineering Department

overview

The main research interest in Lin lab is to understand the etiology and pathogenesis of osteoarthritis, and develop the treating methods accordingly. 1. A human cell derived, three-dimensional (3D), multi-component microphysiological joint chip (microJoint) has been developed, in which osteochondral complexes, synovium and adipose tissues are integrated. This robust in vitro system is being used to study the tissue crosstalk in the onset and progression of osteoarthritis, as well as screen the disease modifying drugs. 2. Aging relevant changes in cartilage/chondrocyte are investigated, with special attention to autophagy. Our final goal is to understand the mechanism underneath the association between aging and osteoarthritis. 3. Stem cell and its biologics-based therapy are also tested for the treatment of musculoskeletal injuries such as focal cartilage defect, which is one of the major reasons leading to the development of osteoarthritis.

about

(2018) 2018 Butler-Williams Scholars.

TERMIS-AM 2014 travel award, 2014.

The WFPC AFIRM career enrichment and travel support award, 2012.

PhD, Cell Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 2002 - 2008

Lin, H., Beck, A.M., Shimomura, K., Sohn, J., Fritch, M.R., Deng, Y., Kilroy, E.J., Tang, Y., Alexander, P.G., & Tuan, R.S. (2019). Optimization of photocrosslinked gelatin/hyaluronic acid hybrid scaffold for the repair of cartilage defect. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 13(8), 1418-1429.Wiley. doi: 10.1002/term.2883.

Lin, H., Tang, Y., Lozito, T.P., Oyster, N., Wang, B., & Tuan, R.S. (2019). Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold. STEM CELL RESEARCH & THERAPY, 10(1), 254.Springer Science and Business Media LLC. doi: 10.1186/s13287-019-1350-6.

Liu, Y., Kuang, B., Rothrauff, B.B., Tuan, R.S., & Lin, H. (2019). Robust bone regeneration through endochondral ossification of human mesenchymal stem cells within their own extracellular matrix. BIOMATERIALS, 218, 119336.Elsevier BV. doi: 10.1016/j.biomaterials.2019.119336.

Yang, Y., Lin, H., Shen, H., Wang, B., Lei, G., & Tuan, R.S. (2018). Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo. ACTA BIOMATERIALIA, 69, 71-82.Elsevier BV. doi: 10.1016/j.actbio.2017.12.043.

Lin, H., Tang, Y., Lozito, T.P., Oyster, N., Kang, R.B., Fritch, M.R., Wang, B., & Tuan, R.S. (2017). Projection Stereolithographic Fabrication of BMP-2 Gene-activated Matrix for Bone Tissue Engineering. SCIENTIFIC REPORTS, 7(1), 11327.Springer Science and Business Media LLC. doi: 10.1038/s41598-017-11051-0.

Lin, H., Cheng, A.W.M., Alexander, P.G., Beck, A.M., & Tuan, R.S. (2014). Cartilage Tissue Engineering Application of Injectable Gelatin Hydrogel with In Situ Visible-Light-Activated Gelation Capability in Both Air and Aqueous Solution. TISSUE ENGINEERING PART A, 20(17-18), 2402-2411.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2013.0642.

Lin, H., Lozito, T., Alexander, P., Gottardi, R., & Tuan, R. (2014). Stem Cell-based Microphysiological Osteochondral System to Model Tissue Response to Interleukin-1 beta. TISSUE ENGINEERING PART A, 20, S5.

Lin, H., Lozito, T.P., Alexander, P.G., Gottardi, R., & Tuan, R.S. (2014). Stem Cell-Based Microphysiological Osteochondral System to Model Tissue Response to Interleukin-1 beta. MOLECULAR PHARMACEUTICS, 11(7), 2203-2212.American Chemical Society (ACS). doi: 10.1021/mp500136b.

Deng, Y., Yang, Y., Lin, H., & Tuan, R. (2017). Generation Of Chondrocytes With Reduced Hypertrophy From Human Mesenchymal Stem Cells By Modulating The Erk1/2 Signaling Pathway. In TISSUE ENGINEERING PART A, 23, (pp. S78-S79).

Lin, H., Sun, A., Yu, G., Fritch, M., Shen, H., Alexander, P., & Tuan, R. (2017). Robust Chondrogenesis of Human Mesenchymal Stem Cells within TGF-beta 3 Loaded Hydrogels: Significant Contribution of Newly Produced Cartilage Matrix to Mechanical Properties. In TISSUE ENGINEERING PART A, 23, (p. S71).

Lin, H., Tang, Y., Lozito, T., Wang, B., & Tuan, R. (2017). 3D Bioprinting of BMP-2 Gene-Activated and Stem Cell-Encapsulated Gelatin Scaffold: Efficacious in situ Transduction and Robust Osteogenesis for Bone Regeneration. In TISSUE ENGINEERING PART A, 23, (pp. S13-S14).

Shen, H., Lin, H., Fritch, M., & Tuan, R. (2017). Soluble Extracellular Matrix Derived from Cartilage and Stem Cells: Application for Inflammation Suppression and Cartilage Regeneration. In TISSUE ENGINEERING PART A, 23, (p. S30).

Yang, Y., Shen, H., Lucas, C., Lin, H., & Tuan, R. (2017). Rapid Condensation And Robust Chondrogenesis Of Human Mesenchymal Stem Cells Within Their Own Extracellular Matrix: The Application For Cartilage Regeneration. In TISSUE ENGINEERING PART A, 23, (pp. S68-S69).

Lin, H., Sun, K., Tang, Y., Yin, W., Wang, B., & Tuan, R.S. (2016). BMP-2 Gene & Cell-functionalized 3D Scaffolds for the Repair of Cranial Bone Defect. In TISSUE ENGINEERING PART A, 22, (p. S70).

Lin, H., Tan, J., Clark, K.L., Tuan, C., Fritch, M.R., & Tuan, R.S. (2016). A Novel Ex Vivo Bone Defect Model and the Assessment of MSC-laden Injectable Scaffold for Bone Regeneration. In TISSUE ENGINEERING PART A, 22, (p. S64).

Shen, H., Lin, H., Sun, A., Song, S., Zhang, Z., Dai, J., & Tuan, R. (2016). Enhancement of Human Mesenchymal Stem Cell Chondrogenesis by Sustained Release of TGF Beta3 within a Graphene Oxide-Incorporated Hydrogel. In TISSUE ENGINEERING PART A, 22, (pp. S101-S102).

Yang, Y., Lin, H., Shen, H., Wang, B., Tan, J., & Tuan, R. (2016). Stem Cell-derived Extracellular Matrix Enhancement of Autologous Chondrocytes Implantation for Articular Cartilage Repair. In TISSUE ENGINEERING PART A, 22, (p. S84).

Research interests

3D printing
Aging-associated osteoarthritis
Cartilage
microphysiological tissue/organ...
Stem cell and tissue engineering