headshot of Douglass Taylor

Douglass Taylor

Distinguished Professor

about

Aleman, J., K, R., Wiegand, C., Schurdak, M.E., Vernetti, L., Gavlock, D., Reese, C., DeBiasio, R., LaRocca, G., Angarita, Y.D., Gough, A., Soto-Gutierrez, A., Behari, J., Yechoor, V.K., Miedel, M.T., Stern, A.M., Banerjee, I., & Taylor, D.L. (2024). A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system. Commun Biol, 7(1), 1317.Springer Nature. doi: 10.1038/s42003-024-07006-7.

Gough, A., Soto-Gutierrez, A., Vernetti, L., Ebrahimkhani, M.R., Stern, A.M., & Taylor, D.L. (2021). Human biomimetic liver microphysiology systems in drug development and precision medicine. Nat Rev Gastroenterol Hepatol, 18(4), 252-268.Springer Nature. doi: 10.1038/s41575-020-00386-1.

Kochanek, P.M., Jackson, T.C., Jha, R.M., Clark, R.S.B., Okonkwo, D.O., Bayır, H., Poloyac, S.M., Wagner, A.K., Empey, P.E., Conley, Y.P., Bell, M.J., Kline, A.E., Bondi, C.O., Simon, D.W., Carlson, S.W., Puccio, A.M., Horvat, C.M., Au, A.K., Elmer, J., Treble-Barna, A., Ikonomovic, M.D., Shutter, L.A., Taylor, D.L., Stern, A.M., Graham, S.H., Kagan, V.E., Jackson, E.K., Wisniewski, S.R., & Dixon, C.E. (2020). Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision. J Neurotrauma, 37(22), 2353-2371.Mary Ann Liebert. doi: 10.1089/neu.2018.6203.

Miedel, M.T., Gavlock, D.C., Jia, S., Gough, A., Taylor, D.L., & Stern, A.M. (2019). Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System. Sci Rep, 9(1), 8341.Springer Nature. doi: 10.1038/s41598-019-44756-5.

Taylor, D.L., Gough, A., Schurdak, M.E., Vernetti, L., Chennubhotla, C.S., Lefever, D., Pei, F., Faeder, J.R., Lezon, T.R., Stern, A.M., & Bahar, I. (2019). Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology. Handb Exp Pharmacol, 260, 327-367.Springer Nature. doi: 10.1007/164_2019_239.

Li, X., George, S.M., Vernetti, L., Gough, A.H., & Taylor, D.L. (2018). A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. Lab Chip, 18(17), 2614-2631.Royal Society of Chemistry (RSC). doi: 10.1039/c8lc00418h.

Stern, A.M., Schurdak, M.E., Bahar, I., Berg, J.M., & Taylor, D.L. (2016). A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. J Biomol Screen, 21(6), 521-534.Elsevier. doi: 10.1177/1087057116635818.

Gough, A.H., Chen, N., Shun, T.Y., Lezon, T.R., Boltz, R.C., Reese, C.E., Wagner, J., Vernetti, L.A., Grandis, J.R., Lee, A.V., Stern, A.M., Schurdak, M.E., & Taylor, D.L. (2014). Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. In Paulmurugan, R. (Ed.). PLoS One, 9(7), e102678.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0102678.

Bhushan, A., Senutovitch, N., Bale, S.S., McCarty, W.J., Hegde, M., Jindal, R., Golberg, I., Berk Usta, O., Yarmush, M.L., Vernetti, L., Gough, A., Bakan, A., Shun, T.Y., DeBiasio, R., & Lansing Taylor, D. (2013). Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans. Stem Cell Res Ther, 4 Suppl 1(Suppl 1), S16.Springer Nature. doi: 10.1186/scrt377.