headshot

Charles Sfeir

Associate Professor
Bioengineering Department

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(2010) Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (F31).

(1995) Young Investigator Award American Association of Dental Research, Chicago Chapter.

(1994) Fifth Annual Dental Research Symposium, First Place Award Northwestern University Chicago.

(1992) Young Investigator’s Competition, First Place Award Fifth International Conference on the Chemistry And Biology of the Mineralized Tissues.

(1990 - 1996) Dentist Scientist Award for Ph.D. Training National Institute of Dental and Craniofacial Research.

Ph.D., Molecular Biology and Biochemistry Thesis: Phosphorylation of dentin extracellular matrix proteins by protein kinases, Northwestern University, 1990 - 1996

D.D.S., Thesis: Pathological Relationship and Treatment of the Opening Between the Oral and Sinus Cavities, Universite Louis Pasteur of Dental Surgery, 1985 - 1990

Pacheco, C.M.F., Maltos, K.L.M., Shehabeldin, M.S., Thomas, L.L., Zhuang, Z., Yoshizawa, S., Verdelis, K., Gaffen, S.L., Garlet, G.P., Little, S.R., & Sfeir, C. (2021). Local Sustained Delivery of Anti-IL-17A Antibodies Limits Inflammatory Bone Loss in Murine Experimental Periodontitis. JOURNAL OF IMMUNOLOGY, 206(10), 2386-2392.The American Association of Immunologists. doi: 10.4049/jimmunol.2001432.

Zaky, S.H., Shehabeldin, M., Ray, H., & Sfeir, C. (2021). THE ROLE OF INFLAMMATION MODULATION IN DENTAL PULP REGENERATION. EUROPEAN CELLS & MATERIALS, 41, 184-193.European Cells and Materials. doi: 10.22203/eCM.v041a13.

Zaky, S.H., AlQahtani, Q., Chen, J., Patil, A., Taboas, J., Beniash, E., Jr, R.H., & Sfeir, C. (2020). Effect of the Periapical "Inflammatory Plug" on Dental Pulp Regeneration: A Histologic In Vivo Study. JOURNAL OF ENDODONTICS, 46(1), 51-56.Elsevier BV. doi: 10.1016/j.joen.2019.10.006.

Hong, D., Zaky, S.H., Chong, R., Lukashova, L., Beniash, E., Verdelis, K., Witte, F., & Sfeir, C. (2019). Controlling magnesium corrosion and degradation-regulating mineralization using matrix GLA protein. ACTA BIOMATERIALIA, 98, 142-151.Elsevier BV. doi: 10.1016/j.actbio.2019.05.048.

Hung, C.C., Chaya, A., Liu, K., Verdelis, K., & Sfeir, C. (2019). The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway. ACTA BIOMATERIALIA, 98, 246-255.Elsevier BV. doi: 10.1016/j.actbio.2019.06.001.

Zhao, D., Brown, A., Wang, T., Yoshizawa, S., Sfeir, C., & Heineman, W.R. (2018). In vivo quantification of hydrogen gas concentration in bone marrow surrounding magnesium fracture fixation hardware using an electrochemical hydrogen gas sensor. ACTA BIOMATERIALIA, 73, 559-566.Elsevier BV. doi: 10.1016/j.actbio.2018.04.032.

Zaky, S.H., Lee, K.W., Gao, J., Jensen, A., Verdelis, K., Wang, Y., Almarza, A.J., & Sfeir, C. (2017). Poly (glycerol sebacate) elastomer supports bone regeneration by its mechanical properties being closer to osteoid tissue rather than to mature bone. ACTA BIOMATERIALIA, 54, 95-106.Elsevier BV. doi: 10.1016/j.actbio.2017.01.053.

Anjomshoaa, I., Briseno-Ruiz, J., Deeley, K., Poletta, F.A., Mereb, J.C., Leite, A.L., Barreta, P.A.T.M., Silva, T.L., Dizak, P., Ruff, T., Patir, A., Koruyucu, M., Abbasoglu, Z., Casado, P.L., Brown, A., Zaky, S.H., Bayram, M., Kuechler, E.C., Cooper, M.E., Liu, K., Marazita, M.L., Tanboga, I., Granjeiro, J.M., Seymen, F., Castilla, E.E., Orioli, I.M., Sfeir, C., Owyang, H., Buzalaf, M.A.R., & Vieira, A.R. (2015). Aquaporin 5 Interacts with Fluoride and Possibly Protects against Caries. In Divaris, K. (Ed.). PLOS ONE, 10(12), e0143068.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0143068.

Brown, A., Zaky, S., Jr, R.H., & Sfeir, C. (2015). Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction. ACTA BIOMATERIALIA, 11(C), 543-553.Elsevier BV. doi: 10.1016/j.actbio.2014.09.008.

Chaya, A., Yoshizawa, S., Verdelis, K., Myers, N., Costello, B.J., Chou, D.T., Pal, S., Maiti, S., Kumta, P.N., & Sfeir, C. (2015). In vivo study of magnesium plate and screw degradation and bone fracture healing. ACTA BIOMATERIALIA, 18, 262-269.Elsevier BV. doi: 10.1016/j.actbio.2015.02.010.

Chaya, A., Yoshizawa, S., Verdelis, K., Noorani, S., Costello, B.J., & Sfeir, C. (2015). Fracture Healing Using Degradable Magnesium Fixation Plates and Screws. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 73(2), 295-305.Elsevier BV. doi: 10.1016/j.joms.2014.09.007.

Yoshizawa, S., Chaya, A., Verdelis, K., Bilodeau, E.A., & Sfeir, C. (2015). An in vivo model to assess magnesium alloys and their biological effect on human bone marrow stromal cells. ACTA BIOMATERIALIA, 28, 234-239.Elsevier BV. doi: 10.1016/j.actbio.2015.08.037.

Sfeir, C., Fang, P.A., Jayaraman, T., Raman, A., Xiaoyuan, Z., & Beniash, E. (2014). Synthesis of bone-like nanocomposites using multiphosphorylated peptides. ACTA BIOMATERIALIA, 10(5), 2241-2249.Elsevier BV. doi: 10.1016/j.actbio.2014.01.007.

Syed-Picard, F.N., Shah, G.A., Costello, B.J., & Sfeir, C. (2014). Regeneration of Periosteum by Human Bone Marrow Stromal Cell Sheets. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 72(6), 1078-1083.Elsevier BV. doi: 10.1016/j.joms.2014.02.005.

Yoshizawa, S., Brown, A., Barchowsky, A., & Sfeir, C. (2014). Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation. ACTA BIOMATERIALIA, 10(6), 2834-2842.Elsevier BV. doi: 10.1016/j.actbio.2014.02.002.

Sfeir, C., Lee, D., Li, J., Zhang, X., Boskey, A.L., & Kumta, P.N. (2011). Expression of Phosphophoryn Is Sufficient for the Induction of Matrix Mineralization by Mammalian Cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(23), 20228-20238.Elsevier BV. doi: 10.1074/jbc.M110.209528.

(2010). Regenerative medicine for craniomaxillofacial surgery. Oral Maxillofac Surg Clin North Am, 22, 33-42.

Ko, H.F., Sfeir, C., & Kumta, P.N. (2010). Novel synthesis strategies for natural polymer and composite biomaterials as potential scaffolds for tissue engineering. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 368(1917), 1981-1997.The Royal Society. doi: 10.1098/rsta.2010.0009.

(2009). Cell Derived Hierarchical Assembly of a Novel Phosphophoryn-Based Biomaterial. Cells Tissues Organs. 2008(Epub).

(2009). Biodegradable Mg corrosion and osteoblast cell culture studies. Materials Science and Engineering C,. 29, 1814-1821.

(2007). Influence of the Synthesis Parameters on the Transfection Efficiency of Nanostructured Calcium Phosphates (NanoCaPs) for Non-Viral Gene Delivery. Biomaterials, 28, 1267-1279.

Ko, H.F., Sfeir, C., & Kumta, P.N. (2007). In situ synthesis and characterization of porous polymer-ceramic composites as scaffolds for gene delivery. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 27(3), 479-483.Elsevier BV. doi: 10.1016/j.msec.2006.05.045.

(2006). ECM-mediated signaling by dentin phosphophoryn involves activation of the Smad pathway independent of BMP. J Biol Chem., 281, 5341-7.

(2005). Novel Synthesis and Characterization of Nanostructured Calcium Phosphates for Biomedical Applications. Acta Biomaterialia, 1, 56-83.

Sfeir, C., Ho, L., Doll, B.A., Azari, K., & Hollinger, J.O. (2005). Fracture Repair. In Bone Regeneration and Repair. (pp. 21-44).Humana Press. doi: 10.1385/1-59259-863-3:021.

Jadlowiec, J., Koch, H., Zhang, X.Y., Campbell, P.G., Seyedain, M., & Sfeir, C. (2004). Phosphophoryn regulates the gene expression and differentiation of NIH3T3, MC3T3-E1, and human mesenchymal stem cells via the integrin/MAPK signaling pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(51), 53323-53330.Elsevier BV. doi: 10.1074/jbc.M404934200.

Narayan, R.J., Kumta, P.N., Sfeir, C., Lee, D.H., Olton, D., & Choi, D.W. (2004). Nanostructured ceramics in medical devices: Applications and prospects. JOM, 56(10), 38-43.Springer Science and Business Media LLC. doi: 10.1007/s11837-004-0289-x.

Pola, E., Gao, W., Zhou, Y., Pola, R., Lattanzi, W., Sfeir, C., Gambotto, A., & Robbins, P. (2004). Efficient bone formation by gene transfer of human LIM mineralization protein-3. GENE THERAPY, 11(8), 683-693.Springer Science and Business Media LLC. doi: 10.1038/sj.gt.3302207.

(2002). A Review of Therapeutic Potential of Bone Morphogenetic Proteins. Expert Opin. Investig. Drugs, 10, 1677-1686.

Thomas, C.H., Collier, J.H., Sfeir, C.S., & Healy, K.E. (2002). Engineering gene expression and protein synthesis by modulation of nuclear shape. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(4), 1972-1977.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.032668799.

(2001). Critical Aspects of Tissue Engineered Therapy for Bone Regeneration. Critical Reviews in Eukaryotic Gene Expression, 11(-3)), 173-98.

Doll, B., Sfeir, C., Winn, S., Huard, J., & Hollinger, J. (2001). Critical aspects of tissue-engineered therapy for bone regeneration. 11, 173-198.Begell House. doi: 10.1615/critreveukargeneexpr.v11.i1-3.90.

Winn, S.R., Hua, Y.H., Sfeir, C., & Hollinger, J.O. (2000). Gene therapy approaches for modulating bone regeneration. ADVANCED DRUG DELIVERY REVIEWS, 42(1-2), 121-138.Elsevier BV. doi: 10.1016/S0169-409X(00)00057-0.

Veis, A., Wei, K.R., Sfeir, C., George, A., & Malone, J. (1998). Properties of the (DSS)(n) triplet repeat domain of rat dentin phosphophoryn. EUROPEAN JOURNAL OF ORAL SCIENCES, 106(S1), 234-238.Wiley. doi: 10.1111/j.1600-0722.1998.tb02181.x.

Shen, E.C., Chen, C.L., Sfeir, C., & Gargiulo, A.V. (1997). Treatment of intrabony defects by polylactic acid matrix barrier--a one-year follow-up study. Periodontal Clin Investig, 19(2), 22-25.

Veis, A., Sfeir, C., & Wu, C.B. (1997). Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity. CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 8(4), 360-379.SAGE Publications. doi: 10.1177/10454411970080040101.

(1996). The Membrane Associated Kinases Which Phosphorylate Bone and Dentine Extracellular Matrix Phosphoproteins are Isoforms of Cytosolic CK II. J. Connective Tissue Research, 35(-4)), 215-222.

Gargiulo, A.V., Chen, P.W., & Sfeir, C. (1996). Use of a bioresorbable pin and membrane barrier for guided-tissue regeneration. 89, 26-28.Chicago Dental Society Review.

SFEIR, C., & VEIS, A. (1995). CASEIN KINASE LOCALIZATION IN THE ENDOPLASMIC-RETICULUM OF THE ROS-17/2.8 CELL-LINE. JOURNAL OF BONE AND MINERAL RESEARCH, 10(4), 607-615.Wiley. doi: 10.1002/jbmr.5650100414.

Trounson, A., Kolaja, K., Petersen, T., Weber, K., McVean, M., & Funk, K.A. (2015). Stem Cell Research. University of Pittsburgh, Pittsburgh, PA. Faculty Development..United States. doi: 10.1177/1091581815581423.

Li, J., Olton, D., Lee, D., Kumta, P.N., & Sfeir, C. (2009). Cell Derived Hierarchical Assembly of a Novel Phosphophoryn-Based Biomaterial. In CELLS TISSUES ORGANS, 189(1-4), (pp. 252-255).S. Karger AG.Switzerland. doi: 10.1159/000158571.

Olton, D., Lee, D.H., Sfeir, C., & Kumta, P.N. (2007). Novel Nanostructured Calcium Phosphate Based Delivery Systems for Non-Viral Gene Delivery. In ASME 2007 Summer Bioengineering Conference, (pp. 1001-1002).American Society of Mechanical Engineers. doi: 10.1115/sbc2007-176286.

Sfeir, C. (2006). The mineralized extracellular "matrix" reloaded: a tissue engineering perspective. 36th International Sun Valley workshop On Skeletal Tissue Biology..Greece.

Sfeir, C., Bennett, J., & Kumta, P. (2003). Nanosized calcium phosphate particles for plasmid gene delivery. In MOLECULAR THERAPY, 7(5), (p. S225).

Veis, A., Wei, K., Sfeir, C., George, A., & Malone, J. (1998). Properties of the (DSS)n triplet repeat domain of rat dentin phosphophoryn. International Conference on Tooth Morphogenesis and Differentiation. doi: 10.1111/j.1600-0722.1998.tb02181.x.

SFEIR, C., & VEIS, A. (1995). THE DETECTION OF MULTIPLE CASEIN KINASE-II BETA-SUBUNIT MESSENGER-RNA TRANSCRIPTS IN BOVINE ODONTOBLASTS. In JOURNAL OF DENTAL RESEARCH, 74, (p. 154).

SFEIR, C., & VEIS, A. (1994). LOCALIZATION OF THE KINASES INVOLVED IN PHOSPHORYLATING THE EXTRACELLULAR-MATRIX PHOSPHOPROTEINS. In JOURNAL OF DENTAL RESEARCH, 73, (p. 147).