headshot of Andrew Duncan

Andrew Duncan

Associate Professor
Bioengineering Department


Ayoob, J.C., Boyce, R.D., Livshits, S., Bruno, T.C., Delgoffe, G.M., Galson, D.L., Duncan, A.W., Atkinson, J.M., Oesterreich, S., Evans, S., Alikhani, M., Baker, T.A., Pratt, S., DeHaan, K.J., Chen, Y., & Boone, D.N. (2022). Getting to YES: The Evolution of the University of Pittsburgh Medical Center Hillman Cancer Center Youth Enjoy Science (YES) Academy. J STEM Outreach, 5(2).Vanderbilt University Library. doi: 10.15695/jstem/v5i2.02.

Barajas, J.M., Lin, C.H., Sun, H.L., Alencastro, F., Zhu, A.C., Aljuhani, M., Navari, L., Yilmaz, S.A., Yu, L., Corps, K., He, C., Duncan, A.W., & Ghoshal, K. (2022). METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice. AMERICAN JOURNAL OF PATHOLOGY, 192(1), 56-71.Elsevier BV. doi: 10.1016/j.ajpath.2021.09.005.

Ma, J., Tan, X., Kwon, Y., Delgado, E.R., Zarnegar, A., DeFrances, M.C., Duncan, A.W., & Zarnegar, R. (2022). A Novel Humanized Model of NASH and Its Treatment With META4, A Potent Agonist of MET. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 13(2), 565-582.Elsevier BV. doi: 10.1016/j.jcmgh.2021.10.007.

Roy, N., Alencastro, F., Roseman, B.A., Wilson, S.R., Delgado, E.R., May, M.C., Bhushan, B., Bello, F.M., Jurczak, M.J., Shiva, S., Locker, J., Gingras, S., & Duncan, A.W. (2022). Dysregulation of Lipid and Glucose Homeostasis in Hepatocyte-Specific SLC25A34 Knockout Mice. AMERICAN JOURNAL OF PATHOLOGY, 192(9), 1259-1281.Elsevier BV. doi: 10.1016/j.ajpath.2022.06.002.

Wang, H., Lu, J., Alencastro, F., Roberts, A., Fiedor, J., Carroll, P., Eisenman, R.N., Ranganathan, S., Torbenson, M., Duncan, A.W., & Prochownik, E.V. (2022). Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 13(6), 1785-1804.Elsevier BV. doi: 10.1016/j.jcmgh.2022.02.018.

Wilson, S.R., & Duncan, A.W. (2022). Single-Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution. GASTROENTEROLOGY, 162(1), 46-48.Elsevier BV. doi: 10.1053/j.gastro.2021.09.065.

Delgado, E.R., Erickson, H.L., Tao, J., Monga, S.P., Duncan, A.W., & Anakk, S. (2021). Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling. MOLECULAR AND CELLULAR BIOLOGY, 41(4).Informa UK Limited. doi: 10.1128/MCB.00596-20.

Wilkinson, P.D., & Duncan, A.W. (2021). Differential Roles for Diploid and Polyploid Hepatocytes in Acute and Chronic Liver Injury. SEMINARS IN LIVER DISEASE, 41(01), 42-49.Georg Thieme Verlag KG. doi: 10.1055/s-0040-1719175.

Duncan, A.W. (2020). Single-Cell and Bulk Transcriptome Profiling Reveals Unique Features of Diploid and Polyploid Hepatocytes. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 9(1), 193-194.Elsevier BV. doi: 10.1016/j.jcmgh.2019.09.008.

Duncan, A.W. (2020). Hepatocyte ploidy modulation in liver cancer. EMBO REPORTS, 21(12), e51922.EMBO. doi: 10.15252/embr.202051922.

Gliozzi, M.L., Espiritu, E.B., Shipman, K.E., Rbaibi, Y., Long, K.R., Roy, N., Duncan, A.W., Lazzara, M.J., Hukriede, N.A., Baty, C.J., & Weisz, O.A. (2020). Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 31(1), 67-83.Ovid Technologies (Wolters Kluwer Health). doi: 10.1681/ASN.2019020125.

Stahl, E.C., Delgado, E.R., Alencastro, F., LoPresti, S.T., Wilkinson, P.D., Roy, N., Haschak, M.J., Skillen, C.D., Monga, S.P., Duncan, A.W., & Brown, B.N. (2020). Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2. AMERICAN JOURNAL OF PATHOLOGY, 190(2), 372-387.Elsevier BV. doi: 10.1016/j.ajpath.2019.10.016.

Takeishi, K., de l'Hortet, A.C., Wang, Y., Handa, K., Guzman-Lepe, J., Matsubara, K., Morita, K., Jang, S., Haep, N., Florentino, R.M., Yuan, F., Fukumitsu, K., Tobita, K., Sun, W., Franks, J., Delgado, E.R., Shapiro, E.M., Fraunhoffer, N.A., Duncan, A.W., Yagi, H., Mashimo, T., Fox, I.J., & Soto-Gutierrez, A. (2020). Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells. CELL REPORTS, 31(9), 107711.Elsevier BV. doi: 10.1016/j.celrep.2020.107711.

Xue, Y., Bhushan, B., Mars, W.M., Bowen, W., Tao, J., Orr, A., Stoops, J., Yu, Y., Luo, J., Duncan, A.W., & Michalopoulos, G.K. (2020). Phosphorylated Ezrin (Thr567) Regulates Hippo Pathway and Yes-Associated Protein (Yap) in Liver. AMERICAN JOURNAL OF PATHOLOGY, 190(7), 1427-1437.Elsevier BV. doi: 10.1016/j.ajpath.2020.03.014.

Wilkinson, P.D., Alencastro, F., Delgado, E.R., Leek, M.P., Weirich, M.P., Otero, P.A., Roy, N., Brown, W.K., Oertel, M., & Duncan, A.W. (2019). Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury. AMERICAN JOURNAL OF PATHOLOGY, 189(6), 1241-1255.Elsevier BV. doi: 10.1016/j.ajpath.2019.02.008.

Wilkinson, P.D., Delgado, E.R., Alencastro, F., Leek, M.P., Roy, N., Weirich, M.P., Stahl, E.C., Otero, P.A., Chen, M.I., Brown, W.K., & Duncan, A.W. (2019). The Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice. HEPATOLOGY, 69(3), 1242-1258.Ovid Technologies (Wolters Kluwer Health). doi: 10.1002/hep.30286.

Wang, H., Dolezal, J.M., Kulkarni, S., Lu, J., Mandel, J., Jackson, L.E., Alencastro, F., Duncan, A.W., & Prochownik, E.V. (2018). Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice. JOURNAL OF BIOLOGICAL CHEMISTRY, 293(38), 14740-14757.Elsevier BV. doi: 10.1074/jbc.RA118.004099.

Jackson, L.E., Kulkarni, S., Wang, H., Lu, J., Dolezal, J.M., Bharathi, S.S., Ranganathan, S., Patel, M.S., Deshpande, R., Alencastro, F., Wendell, S.G., Goetzman, E.S., Duncan, A.W., & Prochownik, E.V. (2017). Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation. CANCER RESEARCH, 77(21), 5795-5807.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-17-1325.

Edmunds, L.R., Otero, P.A., Sharma, L., D'Souza, S., Dolezal, J.M., David, S., Lu, J., Lamm, L., Basantani, M., Zhang, P., Sipula, I.J., Li, L., Zeng, X., Ding, Y., Ding, F., Beck, M.E., Vockley, J., Monga, S.P.S., Kershaw, E.E., O'Doherty, R.M., Kratz, L.E., Yates, N.A., Goetzman, E.P., Scott, D., Duncan, A.W., & Prochownik, E.V. (2016). Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes. ONCOTARGET, 7(21), 30379-30395.Impact Journals, LLC. doi: 10.18632/oncotarget.8856.

Hsu, S.H., Delgado, E.R., Otero, P.A., Teng, K.Y., Kutay, H., Meehan, K.M., Moroney, J.B., Monga, J.K., Hand, N.J., Friedman, J.R., Ghoshal, K., & Duncan, A.W. (2016). MicroRNA-122 Regulates Polyploidization in the Murine Liver. HEPATOLOGY, 64(2), 599-615.Ovid Technologies (Wolters Kluwer Health). doi: 10.1002/hep.28573.

Duncan, A.W. (2015). Changes in Hepatocyte Ploidy During Liver Regeneration. In Liver Regeneration. (pp. 167-184).Elsevier. doi: 10.1016/b978-0-12-420128-6.00012-9.

Hsu, S.H., & Duncan, A.W. (2015). Pathological polyploidy in liver disease. HEPATOLOGY, 62(3), 968-970.Ovid Technologies (Wolters Kluwer Health). doi: 10.1002/hep.27908.

Duncan, A.W. (2013). Aneuploidy, polyploidy and ploidy reversal in the liver. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 24(4), 347-356.Elsevier BV. doi: 10.1016/j.semcdb.2013.01.003.

Duncan, A.W., & Soto-Gutierrez, A. (2013). Liver repopulation and regeneration: new approaches to old questions. CURRENT OPINION IN ORGAN TRANSPLANTATION, 18(2), 197-202.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/MOT.0b013e32835f07e2.

Kurinna, S., Stratton, S.A., Coban, Z., Schumacher, J.M., Grompe, M., Duncan, A.W., & Barton, M.C. (2013). p53 Regulates a Mitotic Transcription Program and Determines Ploidy in Normal Mouse Liver. HEPATOLOGY, 57(5), 2004-2013.Ovid Technologies (Wolters Kluwer Health). doi: 10.1002/hep.26233.

Duncan, A.W., Newell, A.E.H., Bi, W., Finegold, M.J., Olson, S.B., Beaudet, A.L., & Grompe, M. (2012). Aneuploidy as a mechanism for stress-induced liver adaptation. JOURNAL OF CLINICAL INVESTIGATION, 122(9), 3307-3315.American Society for Clinical Investigation. doi: 10.1172/JCI64026.

Duncan, A.W., Newell, A.E.H., Smith, L., Wilson, E.M., Olson, S.B., Thayer, M.J., Strom, S.C., & Grompe, M. (2012). Frequent Aneuploidy Among Normal Human Hepatocytes. GASTROENTEROLOGY, 142(1), 25-28.Elsevier BV. doi: 10.1053/j.gastro.2011.10.029.

Dorrell, C., Erker, L., Schug, J., Kopp, J.L., Canaday, P.S., Fox, A.J., Smirnova, O., Duncan, A.W., Finegold, M.J., Sander, M., Kaestner, K.H., & Grompe, M. (2011). Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. GENES & DEVELOPMENT, 25(11), 1193-1203.Cold Spring Harbor Laboratory. doi: 10.1101/gad.2029411.

Duncan, A.W., Taylor, M.H., Hickey, R.D., Newell, A.E.H., Lenzi, M.L., Olson, S.B., Finegold, M.J., & Grompe, M. (2010). The ploidy conveyor of mature hepatocytes as a source of genetic variation. NATURE, 467(7316), 707-U93.Springer Science and Business Media LLC. doi: 10.1038/nature09414.

Zhang, Q.S., Marquez-Loza, L., Eaton, L., Duncan, A.W., Goldman, D.C., Anur, P., Watanabe-Smith, K., Rathbun, R.K., Fleming, W.H., Bagby, G.C., & Grompe, M. (2010). Fancd2(-/-) mice have hematopoietic defects that can be partially corrected by resveratrol. BLOOD, 116(24), 5140-5148.American Society of Hematology. doi: 10.1182/blood-2010-04-278226.

Duncan, A.W., Dorrell, C., & Grompe, M. (2009). Stem Cells and Liver Regeneration. GASTROENTEROLOGY, 137(2), 466-481.Elsevier BV. doi: 10.1053/j.gastro.2009.05.044.

Duncan, A.W., Hickey, R.D., Paulk, N.K., Culberson, A.J., Olson, S.B., Finegold, M.J., & Grompe, M. (2009). Ploidy Reductions in Murine Fusion-Derived Hepatocytes. PLOS GENETICS, 5(2), e1000385.Public Library of Science (PLoS). doi: 10.1371/journal.pgen.1000385.

DiMascio, L., Voermans, C., Uqoezwa, M., Duncan, A., Lu, D., Wu, J., Sankar, U., & Reya, T. (2007). Identification of adiponectin as a novel hemopoietic stem cell growth factor. JOURNAL OF IMMUNOLOGY, 178(6), 3511-3520.The American Association of Immunologists. doi: 10.4049/jimmunol.178.6.3511.

Duncan, A.W., Rattis, F.M., DiMascio, L.N., Congdon, K.L., Pazianos, G., Zhao, C., Yoon, K., Cook, J.M., Willert, K., Gaiano, N., & Reya, T. (2005). Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. NATURE IMMUNOLOGY, 6(3), 314-322.Springer Science and Business Media LLC. doi: 10.1038/ni1164.

Kitsos, C.M., Sankar, U., Illario, M., Colomer-Font, J.M., Duncan, A.W., Ribr, T.J., Reya, T., & Means, A.R. (2005). Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. JOURNAL OF BIOLOGICAL CHEMISTRY, 280(39), 33101-33108.Elsevier BV. doi: 10.1074/jbc.M505208200.

Reya, T., Duncan, A.W., Ailles, L., Domen, J., Scherer, D.C., Willert, K., Hintz, L., Nusse, R., & Weissman, I.L. (2003). A role for Wnt signalling in self-renewal of haematopoietic stem cells. NATURE, 423(6938), 409-414.Springer Science and Business Media LLC. doi: 10.1038/nature01593.

Willert, K., Brown, J.D., Danenberg, E., Duncan, A.W., Weissman, I.L., Reya, T., Yates, J.R., & Nusse, R. (2003). Wnt proteins are lipid-modified and can act as stem cell growth factors. NATURE, 423(6938), 448-452.Springer Science and Business Media LLC. doi: 10.1038/nature01611.

Cao, Y.J., Janssen, E.M., Duncan, A.W., Altman, A., Billadeau, D.D., & Abraham, R.T. (2002). Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO JOURNAL, 21(18), 4809-4819.Wiley. doi: 10.1093/emboj/cdf499.

BaSalamah, M.A.M., Marr, H.S., Duncan, A.W., & Edgell, C.J.S. (2001). Testican in human blood. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 283(5), 1083-1090.Elsevier BV. doi: 10.1006/bbrc.2001.4900.

Marr, H.S., Basalamah, M.A., Bouldin, T.W., Duncan, A.W., & Edgell, C.J.S. (2000). Distribution of testican expression in human brain. CELL AND TISSUE RESEARCH, 302(2), 139-144.Springer Science and Business Media LLC. doi: 10.1007/s004410000277.

Wang, H., Lu, J., Alencastro, F., Roberts, A., Fiedor, J., Carroll, P., Eisenman, R.N., Ranganathan, S., Torbenson, M., Duncan, A.W., & Prochownik, E.V. Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia. Cold Spring Harbor Laboratory. doi: 10.1101/2021.08.05.455215.

Roy, N., May, M., Delgado, E., Alencastro, F., Wilkinson, P., Smyers, M., Reynolds, M., Shiva, S., & Duncan, A. (2020). SLC25A34 regulates bioenergetic metabolism in the murine liver. In FASEB JOURNAL, 34(S1), (p. 1).Wiley. doi: 10.1096/fasebj.2020.34.s1.03444.


Delgado, E.R., & Duncan, A.W. (2017). Regulation of Oncogenic Signaling Pathways in Hepatocellular Carcinoma by the Pleiotropic Scaffold Protein IQGAP1. In AMERICAN JOURNAL OF PATHOLOGY, 187(10), (pp. 2369-2370).

Khan, Z., Zhang, P., Bowen, W.C., Alencastro, F., Duncan, A.W., Stolz, D.B., & Michalopoulos, G.K. (2017). Age-dependent effects of intracellular ATZ protein globules on hepatocyte proliferation and ploidy in alpha-1 antitrypsin deficiency. In HEPATOLOGY, 66, (p. 716A).

Roy, N., Wilkinson, P.D., Delgado, E.R., Alencastro, F., Leek, M.P., Corey, C.G., Shiva, S., & Duncan, A.W. (2017). A Role for SLC25A34, a Putative Oxaloacetate Carrier, in Non-Alcoholic Fatty Liver Disease. In AMERICAN JOURNAL OF PATHOLOGY, 187(10), (pp. 2368-2369).

Wilkinson, P.D., Otero, P., Alencastro, F., Delgado, E.R., Roy, N., Leek, M., Weirich, M.P., Oertel, M., & Duncan, A.W. (2017). A Role for Polyploid Hepatocytes in Liver Repopulation and Adaptation to Chronic Injury. In AMERICAN JOURNAL OF PATHOLOGY, 187(10), (p. 2366).

Hsu, S.H., Delgado, E., Otero, P.A., Meehan, K., Moroney, J.B., Teng, K.Y., Ghoshal, K., & Duncan, A.W. (2015). MicroRNA-122 (miR-122) Regulates Polyploidy in the Liver. In HEPATOLOGY, 62, (p. 457A).