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Alberto Vazquez

Associate Professor
Assistant Professor
Bioengineering Department

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Abrahamson, E.E., Stehouwer, J.S., Vazquez, A.L., Huang, G.F., Mason, N.S., Lopresti, B.J., Klunk, W.E., Mathis, C.A., & Ikonomovic, M.D. (2021). Development of a PET radioligand selective for cerebral amyloid angiopathy. NUCLEAR MEDICINE AND BIOLOGY, 92, 85-96.Elsevier BV. doi: 10.1016/j.nucmedbio.2020.05.001.

Moon, H.S., Jiang, H., Vo, T.T., Jung, W.B., Vazquez, A.L., & Kim, S.G. (2021). Contribution of Excitatory and Inhibitory Neuronal Activity to BOLD fMRI. Cereb Cortex, 31(9), 4053-4067.Oxford University Press (OUP). doi: 10.1093/cercor/bhab068.

Poplawsky, A.J., Iordanova, B., Vazquez, A.L., Kim, S.G., & Fukuda, M. (2021). Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses. NEUROIMAGE, 225, 117457.Elsevier BV. doi: 10.1016/j.neuroimage.2020.117457.

Yang, Q., Vazquez, A.L., & Cui, X.T. (2021). Long-term in vivo two-photon imaging of the neuroinflammatory response to intracortical implants and micro-vessel disruptions in awake mice. BIOMATERIALS, 276, 121060.Elsevier BV. doi: 10.1016/j.biomaterials.2021.121060.

Krawchuk, M.B., Ruff, C.F., Yang, X., Ross, S.E., & Vazquez, A.L. (2020). Optogenetic assessment of VIP, PV, SOM and NOS inhibitory neuron activity and cerebral blood flow regulation in mouse somato-sensory cortex. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 40(7), 1427-1440.SAGE Publications. doi: 10.1177/0271678X19870105.

Yang, Q., Wu, B., Eles, J.R., Vazquez, A.L., Kozai, T.D.Y., & Cui, X.T. (2020). Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo. ADVANCED BIOSYSTEMS, 4(6), e1900287.Wiley. doi: 10.1002/adbi.201900287.

Baranov, S.V., Baranova, O.V., Yablonska, S., Suofu, Y., Vazquez, A.L., Kozai, T.D.Y., Cui, X.T., Ferrando, L.M., Larkin, T.M., Tyurina, Y.Y., Kagan, V.E., Carlisle, D.L., Kristal, B.S., & Friedlander, R.M. (2019). Mitochondria modulate programmed neuritic retraction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(2), 650-659.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1811021116.

Eles, J.R., Vazquez, A.L., Kozai, T.D.Y., & Cui, X.T. (2019). Meningeal inflammatory response and fibrous tissue remodeling around intracortical implants: An in vivo two-photon imaging study. BIOMATERIALS, 195, 111-123.Elsevier BV. doi: 10.1016/j.biomaterials.2018.12.031.

Iordanova, B., Fukuda, M., Klunk, W., & Vazquez, A.L. (2019). Vascular and metabolic dysfunctions in APP/PS1 mouse model of Alzheimer's disease. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 39, 44-45.

Li, L., Poloyac, S.M., Watkins, S.C., St Croix, C.M., Alexander, H., Gibson, G.A., Loughran, P.A., Kirisci, L., Clark, R.S.B., Kochanek, P.M., Vazquez, A.L., & Manole, M.D. (2019). Cerebral microcirculatory alterations and the no-reflow phenomenon in vivo after experimental pediatric cardiac arrest. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 39(5), 913-925.SAGE Publications. doi: 10.1177/0271678X17744717.

Michelson, N.J., Eles, J.R., Vazquez, A.L., Ludwig, K.A., & Kozai, T.D.Y. (2019). Calcium activation of cortical neurons by continuous electrical stimulation: Frequency dependence, temporal fidelity, and activation density. JOURNAL OF NEUROSCIENCE RESEARCH, 97(5), 620-638.Wiley. doi: 10.1002/jnr.24370.

Stocking, K.C., Vazquez, A.L., & Kozai, T.D.Y. (2019). Intracortical Neural Stimulation With Untethered, Ultrasmall Carbon Fiber Electrodes Mediated by the Photoelectric Effect. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 66(8), 2402-2412.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TBME.2018.2889832.

Williams, J.J., Watson, A.M., Vazquez, A.L., & Schwartz, A.B. (2019). Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates. FRONTIERS IN NEUROSCIENCE, 13(JUL), 759.Frontiers Media SA. doi: 10.3389/fnins.2019.00759.

Eles, J.R., Vazquez, A.L., Kozai, T.D.Y., & Cui, X.T. (2018). In vivo imaging of neuronal calcium during electrode implantation: Spatial and temporal mapping of damage and recovery. BIOMATERIALS, 174, 79-94.Elsevier BV. doi: 10.1016/j.biomaterials.2018.04.043.

Iordanova, B., Vazquez, A., Kozai, T.D.Y., Fukuda, M., & Kim, S.G. (2018). Optogenetic investigation of the variable neurovascular coupling along the interhemispheric circuits. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 38(4), 627-640.SAGE Publications. doi: 10.1177/0271678X18755225.

Masamoto, K., & Vazquez, A. (2018). Optical imaging and modulation of neurovascular responses. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 38(12), 2057-2072.SAGE Publications. doi: 10.1177/0271678X18803372.

Michelson, N.J., Vazquez, A.L., Eles, J.R., Salatino, J.W., Purcell, E.K., Williams, J.J., Cui, X.T., & Kozai, T.D.Y. (2018). Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface. JOURNAL OF NEURAL ENGINEERING, 15(3), 033001.IOP Publishing. doi: 10.1088/1741-2552/aa9dae.

Murphy, M.C., Chan, K.C., Kim, S.G., & Vazquez, A.L. (2018). Macroscale variation in resting-state neuronal activity and connectivity assessed by simultaneous calcium imaging, hemodynamic imaging and electrophysiology. NEUROIMAGE, 169, 352-362.Elsevier BV. doi: 10.1016/j.neuroimage.2017.12.070.

Vazquez, A.L., Fukuda, M., & Kim, S.G. (2018). Inhibitory Neuron Activity Contributions to Hemodynamic Responses and Metabolic Load Examined Using an Inhibitory Optogenetic Mouse Model. CEREBRAL CORTEX, 28(11), 4105-4119.Oxford University Press (OUP). doi: 10.1093/cercor/bhy225.

Wellman, S.M., Eles, J.R., Ludwig, K.A., Seymour, J.P., Michelson, N.J., McFadden, W.E., Vazquez, A.L., & Kozai, T.D.Y. (2018). A Materials Roadmap to Functional Neural Interface Design. ADVANCED FUNCTIONAL MATERIALS, 28(12), 1701269.Wiley. doi: 10.1002/adfm.201701269.

Eles, J.R., Vazquez, A.L., Snyder, N.R., Lagenaur, C., Murphy, M.C., Kozai, T.D.Y., & Cui, X.T. (2017). Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy. BIOMATERIALS, 113, 279-292.Elsevier BV. doi: 10.1016/j.biomaterials.2016.10.054.

Foley, L.M., Clark, R.S.B., Vazquez, A.L., Hitchens, T.K., Alexander, H., Ho, C., Kochanek, P.M., & Manole, M.D. (2017). Enduring disturbances in regional cerebral blood flow and brain oxygenation at 24 h after asphyxial cardiac arrest in developing rats. PEDIATRIC RESEARCH, 81(1), 94-98.Springer Science and Business Media LLC. doi: 10.1038/pr.2016.175.

Li, P., Wang, L., Zhou, Y., Gan, Y., Zhu, W., Xia, Y., Jiang, X., Watkins, S., Vazquez, A., Thomson, A.W., Chen, J., Yu, W., & Hu, X. (2017). C-C Chemokine Receptor Type 5 (CCR5)-Mediated Docking of Transferred Tregs Protects Against Early Blood-Brain Barrier Disruption After Stroke. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 6(8).Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/JAHA.117.006387.

Kozai, T.D.Y., Eles, J.R., Vazquez, A.L., & Cui, X.T. (2016). Two-photon imaging of chronically implanted neural electrodes: Sealing methods and new insights. JOURNAL OF NEUROSCIENCE METHODS, 258, 46-55.Elsevier BV. doi: 10.1016/j.jneumeth.2015.10.007.

Kozai, T.D.Y., Jaquins-Gerstl, A.S., Vazquez, A.L., Michael, A.C., & Cui, X.T. (2016). Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo. BIOMATERIALS, 87, 157-169.Elsevier BV. doi: 10.1016/j.biomaterials.2016.02.013.

Murphy, M.C., Poplawsky, A.J., Vazquez, A.L., Chan, K.C., Kim, S.G., & Fukuda, M. (2016). Improved spatial accuracy of functional maps in the rat olfactory bulb using supervised machine learning approach. NEUROIMAGE, 137, 1-8.Elsevier BV. doi: 10.1016/j.neuroimage.2016.05.055.

Vasireddi, A.K., Vazquez, A.L., Whitney, D.E., Fukuda, M., & Kim, S.G. (2016). Functional Connectivity of Resting Hemodynamic Signals in Submillimeter Orientation Columns of the Visual Cortex. Brain Connect, 6(8), 596-606.Mary Ann Liebert Inc. doi: 10.1089/brain.2015.0414.

Iordanova, B., Vazquez, A.L., Poplawsky, A.J., Fukuda, M., & Kim, S.G. (2015). Neural and hemodynamic responses to optogenetic and sensory stimulation in the rat somato sensory cortex. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 35(6), 922-932.SAGE Publications. doi: 10.1038/jcbfm.2015.10.

Kim, S.G., Jin, T., Kim, T., Vazquez, A., & Fukuda, M. (2015). Animal Model Studies. In fMRI: From Nuclear Spins to Brain Functions. (pp. 633-657).Springer US. doi: 10.1007/978-1-4899-7591-1_22.

Kozai, T.D.Y., & Vazquez, A.L. (2015). Photoelectric artefact from optogenetics and imaging on microelectrodes and bioelectronics: new challenges and opportunities. JOURNAL OF MATERIALS CHEMISTRY B, 3(25), 4965-4978.Royal Society of Chemistry (RSC). doi: 10.1039/c5tb00108k.

Kozai, T.D.Y., Catt, K., Li, X., Gugel, Z.V., Olafsson, V.T., Vazquez, A.L., & Cui, X.T. (2015). Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording. BIOMATERIALS, 37, 25-39.Elsevier BV. doi: 10.1016/j.biomaterials.2014.10.040.

Kozai, T.D.Y., Jaquins-Gerstl, A.S., Vazquez, A.L., Michael, A.C., & Cui, X.T. (2015). Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies. ACS CHEMICAL NEUROSCIENCE, 6(1), 48-67.American Chemical Society (ACS). doi: 10.1021/cn500256e.

Vazquez, A.L., Fukuda, M., Crowley, J.C., & Kim, S.G. (2014). Neural and Hemodynamic Responses Elicited by Forelimb- and Photo-stimulation in Channelrhodopsin-2 Mice: Insights into the Hemodynamic Point Spread Function. CEREBRAL CORTEX, 24(11), 2908-2919.Oxford University Press (OUP). doi: 10.1093/cercor/bht147.

Vazquez, A.L., Murphy, M.C., & Kim, S.G. (2014). Neuronal and physiological correlation to hemodynamic resting-state fluctuations in health and disease. Brain Connect, 4(9), 727-740.Mary Ann Liebert Inc. doi: 10.1089/brain.2014.0276.

Fukuda, M., Vazquez, A.L., Zong, X., & Kim, S.G. (2013). Effects of the a2-adrenergic receptor agonist dexmedetomidine on neural, vascular and BOLD fMRI responses in the somatosensory cortex. EUROPEAN JOURNAL OF NEUROSCIENCE, 37(1), 80-95.Wiley. doi: 10.1111/ejn.12024.

Kozai, T.D.Y., Vazquez, A.L., LWeaver, C., Kim, S.G., & Cui, X.T. (2012). In vivo two-photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes. JOURNAL OF NEURAL ENGINEERING, 9(6), 066001.IOP Publishing. doi: 10.1088/1741-2560/9/6/066001.

Vazquez, A.L., Fukuda, M., & Kim, S.G. (2012). Evolution of the dynamic changes in functional cerebral oxidative metabolism from tissue mitochondria to blood oxygen. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 32(4), 745-758.SAGE Publications. doi: 10.1038/jcbfm.2011.198.

Kim, T., Masamoto, K., Fukuda, M., Vazquez, A., & Kim, S.G. (2010). Frequency-dependent neural activity, CBF, and BOLD fMRI to somatosensory stimuli in isoflurane-anesthetized rats. NEUROIMAGE, 52(1), 224-233.Elsevier BV. doi: 10.1016/j.neuroimage.2010.03.064.

Vazquez, A.L., Fukuda, M., Tasker, M.L., Masamoto, K., & Kim, S.G. (2010). Changes in cerebral arterial, tissue and venous oxygenation with evoked neural stimulation: implications for hemoglobin-based functional neuroimaging. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 30(2), 428-439.SAGE Publications. doi: 10.1038/jcbfm.2009.213.

Vazquez, A.L., Masamoto, K., Fukuda, M., & Kim, S.G. (2010). Cerebral oxygen delivery and consumption during evoked neural activity. Front Neuroenergetics, 2, 11.Frontiers Media SA. doi: 10.3389/fnene.2010.00011.

Hernandez-Garcia, L., Vazquez, A.L., & Rowe, D.B. (2009). Complex-Valued Analysis of Arterial Spin Labeling-Based Functional Magnetic Resonance Imaging Signals. MAGNETIC RESONANCE IN MEDICINE, 62(6), 1597-1608.Wiley. doi: 10.1002/mrm.22106.

Masamoto, K., Fukuda, M., Vazquez, A., & Kim, S.G. (2009). Dose-dependent effect of isoflurane on neurovascular coupling in rat cerebral cortex. EUROPEAN JOURNAL OF NEUROSCIENCE, 30(2), 242-250.Wiley. doi: 10.1111/j.1460-9568.2009.06812.x.

Gulani, V., Adusumilli, S., Hussain, H.K., Vazquez, A.L., Francis, I.R., & Noll, D.C. (2008). Apparent wall thickening of cystic renal lesions on MRI. JOURNAL OF MAGNETIC RESONANCE IMAGING, 28(1), 103-110.Wiley. doi: 10.1002/jmri.21376.

Masainoto, K., Vazquez, A., Wang, P., & Kim, S.G. (2008). Trial-by-trial relationship between neural activity, oxygen consumption, and blood flow responses. NEUROIMAGE, 40(2), 442-450.Elsevier BV. doi: 10.1016/j.neuroimage.2007.12.011.

Vazquez, A.L., Masamoto, K., & Kim, S.G. (2008). Dynamics of oxygen delivery and consumption during stimulation using a compartment model and CBF and tissue P-O2 measurements. NEUROIMAGE, 42(1), 49-59.Elsevier BV. doi: 10.1016/j.neuroimage.2008.04.024.

Vazquez, A.L., Cohen, E.R., Gulani, V., Hernandez-Garcia, L., Zheng, Y., Lee, G.R., Kim, S.G., Grotberg, J.B., & Noll, D.C. (2006). Vascular dynamics and BOLD fMRI: CBF level effects and analysis considerations. NEUROIMAGE, 32(4), 1642-1655.Elsevier BV. doi: 10.1016/j.neuroimage.2006.04.195.

Vazquez, A.L., Lee, G.R., Hernandez-Garcia, L., & Noll, D.C. (2006). Application of selective saturation to image the dynamics of arterial blood flow during brain activation using magnetic resonance imaging. MAGNETIC RESONANCE IN MEDICINE, 55(4), 816-825.Wiley. doi: 10.1002/mrm.20813.

Hernandez-Garcia, L., Lee, G.R., Vazquez, A.L., Yip, C.Y., & Noll, D.C. (2005). Quantification of perfusion fMRI using a numerical model of arterial spin labeling that accounts for dynamic transit time effects. MAGNETIC RESONANCE IN MEDICINE, 54(4), 955-964.Wiley. doi: 10.1002/mrm.20613.

Wager, T.D., Vazquez, A., Hemandez, L., & Noll, D.C. (2005). Accounting for nonlinear BOLD effects in fMRI: parameter estimates and a model for prediction in rapid event-related studies. NEUROIMAGE, 25(1), 206-218.Elsevier BV. doi: 10.1016/j.neuroimage.2004.11.008.

Hernandez-Garcia, L., Lee, G.R., Vazquez, A.L., & Noll, D.C. (2004). Fast, pseudo-continuous arterial spin labeling for functional imaging using a two-coil system. MAGNETIC RESONANCE IN MEDICINE, 51(3), 577-585.Wiley. doi: 10.1002/mrm.10733.

Boada, F.E., Noll, D.C., & Vazquez, A.L. (1998). K-Space Design for Real Time Volumetric fMRI: Initial Experience. NeuroImage, 7(4), S565.Elsevier BV. doi: 10.1016/s1053-8119(18)31398-3.

Noll, D.C., Genovese, C.R., Vazquez, A.L., O'Brien, J.L., & Eddy, W.F. (1998). Evaluation of respiratory artifact correction techniques in multishot spiral functional MRI using receiver operator characteristic analyses. MAGNETIC RESONANCE IN MEDICINE, 40(4), 633-639.Wiley. doi: 10.1002/mrm.1910400417.

Vazquez, A.L., & Noll, D.C. (1998). Nonlinear aspects of the BOLD response in functional MRI. NEUROIMAGE, 7(2), 108-118.Elsevier BV. doi: 10.1006/nimg.1997.0316.

Vazquez, A.L., & Noll, D.C. (1998). Time-invariant Properties of the BOLD Response. NeuroImage, 7(4), S579.Elsevier BV. doi: 10.1016/s1053-8119(18)31412-5.

Noll, D.C., Genovese, C.R., Nystrom, L.E., Vazquez, A.L., Forman, S.D., Eddy, W.F., & Cohen, J.D. (1997). Estimating test-retest reliability in functional MR imaging .2. Application to motor and cognitive activation studies. MAGNETIC RESONANCE IN MEDICINE, 38(3), 508-517.Wiley. doi: 10.1002/mrm.1910380320.

Williams, J.J., Watson, A.M., Vazquez, A.L., & Schwartz, A.B. Viral-mediated optogenetic stimulation of peripheral motor nerves in non-human primates. Cold Spring Harbor Laboratory. doi: 10.1101/261925.

Fukuda, M., Poplawsky, A.J., Iordanova, B., Vazquez, A.L., & Kim, S.G. (2019). Coupling of neuronal activity to blood flow in dendrodendritic synapses is mediated by postsynaptic gabaergic cells in olfactory bulb. In JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 39, (pp. 239-240).

Williams, J.J., Vazquez, A.L., & Schwartz, A.B. (2019). Prolonged functional optical sensitivity in non-human primate motor nerves following cyclosporine-based immunosuppression and rAAV2-retro mediated expression of ChR2. In 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER), 2019-March, (pp. 534-537).IEEE. doi: 10.1109/ner.2019.8716978.

Li, L., Poloyac, S., Waltkins, S., St Croix, C., Alexander, H., Gibson, G., Loughran, P., Clark, R., Kochanek, P., Kirisci, L., Vazquez, A., & Manole, M. (2017). The effect of 20-HETE inhibition by HET0016 on the cerebral microvascular circulation after asphyxial cardiac arrest in pediatric rats. In JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 37, (pp. 286-287).

Manole, M.D., Clark, R.S.B., Kochanek, P.M., Alexander, H., Fukuda, M., Li, L., & Vazquez, A.L. (2017). In vivo assessment of neural and metabolic activity in cortex after pediatric cardiac arrest. In JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 37, (pp. 353-354).

Vazquez, A.L., Fukuda, M., & Kim, S.G. (2017). Optogenetic dissection of inhibitory neuron activity contributions to vascular regulation. In JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 37, (p. 17).

Li, L., Poloyac, S.M., Vazquez, A.L., St Croix, C.M., Alexander, H., Gibson, G., Watkins, S.C., Clark, R.S.B., Kochanek, P.M., & Manole, M.D. (2016). ALTERATIONSD OF THE CEREBRAL MICROVASCULAR CIRCULATION AFTER ASPHYXIAL CARDIAC ARREST IN DEVELOPING RATS. In JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36, (pp. 329-330).

Vazquez, A. (2016). QUANTITATIVE OPTOGENETIC INTERACTION. In JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36, (p. 3).

Vazquez, A., Fukuda, M., & Kim, S.G. (2016). ROLE OF INHIBITORY NEURON ACTIVITY ON VASCULAR REGULATION AND HEMODYNAMIC RESPONSES. In JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36, (pp. 26-28).

Fukuda, M., Vazquez, A., & Kim, S.G. (2011). P2-v06 The relationship between cerebral blood flow responses and changes in venous oxygen saturation level: Implication for the source of the early-negative blood oxygenation signal. In NEUROSCIENCE RESEARCH, 71, (p. E208).Elsevier BV. doi: 10.1016/j.neures.2011.07.904.

Masamoto, K., Vazquez, A., Wang, P., & Kim, S.G. (2009). BRAIN TISSUE OXYGEN CONSUMPTION AND SUPPLY INDUCED BY NEURAL ACTIVATION: Determined under suppressed hemodynamic response conditions in the anesthetized rat cerebral cortex. In OXYGEN TRANSPORT TO TISSUE XXX, 645, (pp. 287-292).Springer US.United States. doi: 10.1007/978-0-387-85998-9_43.

Noll, D.C., & Vazquez, A. (2004). Contrast mechanisms and acquisition methods in functional MRI. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 26 VII, (pp. 5219-5222).