Andrew Duncan

Duncan, A.W. (2024). Pathological polyploidy and liver repair failure in RAD51-deficient mice. Hepatology.Wolters Kluwer. doi: 10.1097/HEP.0000000000000871.

Wilson, S.R., & Duncan, A.W. (2023). The Ploidy State as a Determinant of Hepatocyte Proliferation. Semin Liver Dis, 43(4), 460-471.Thieme. doi: 10.1055/a-2211-2144.

Ayoob, J.C., Boyce, R.D., Livshits, S., Bruno, T.C., Delgoffe, G.M., Galson, D.L., Duncan, A.W., Atkinson, J.M., Oesterreich, S., Evans, S., Alikhani, M., Baker, T.A., Pratt, S., DeHaan, K.J., Chen, Y., & Boone, D.N. (2022). Getting to YES: The Evolution of the University of Pittsburgh Medical Center Hillman Cancer Center Youth Enjoy Science (YES) Academy. J STEM Outreach, 5(2).Vanderbilt University Library. doi: 10.15695/jstem/v5i2.02.

Barajas, J.M., Lin, C.H., Sun, H.L., Alencastro, F., Zhu, A.C., Aljuhani, M., Navari, L., Yilmaz, S.A., Yu, L., Corps, K., He, C., Duncan, A.W., & Ghoshal, K. (2022). METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice. Am J Pathol, 192(1), 56-71.Elsevier. doi: 10.1016/j.ajpath.2021.09.005.

Ma, J., Tan, X., Kwon, Y., Delgado, E.R., Zarnegar, A., DeFrances, M.C., Duncan, A.W., & Zarnegar, R. (2022). A Novel Humanized Model of NASH and Its Treatment With META4, A Potent Agonist of MET. Cell Mol Gastroenterol Hepatol, 13(2), 565-582.Elsevier. doi: 10.1016/j.jcmgh.2021.10.007.

Roy, N., Alencastro, F., Roseman, B.A., Wilson, S.R., Delgado, E.R., May, M.C., Bhushan, B., Bello, F.M., Jurczak, M.J., Shiva, S., Locker, J., Gingras, S., & Duncan, A.W. (2022). Dysregulation of Lipid and Glucose Homeostasis in Hepatocyte-Specific SLC25A34 Knockout Mice. Am J Pathol, 192(9), 1259-1281.Elsevier. doi: 10.1016/j.ajpath.2022.06.002.

Wang, H., Lu, J., Alencastro, F., Roberts, A., Fiedor, J., Carroll, P., Eisenman, R.N., Ranganathan, S., Torbenson, M., Duncan, A.W., & Prochownik, E.V. (2022). Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia. Cell Mol Gastroenterol Hepatol, 13(6), 1785-1804.Elsevier. doi: 10.1016/j.jcmgh.2022.02.018.

Wilson, S.R., & Duncan, A.W. (2022). Single-Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution. Gastroenterology, 162(1), 46-48.Elsevier. doi: 10.1053/j.gastro.2021.09.065.

Delgado, E.R., Erickson, H.L., Tao, J., Monga, S.P., Duncan, A.W., & Anakk, S. (2021). Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling. Mol Cell Biol, 41(4), e00596-e00520.Taylor & Francis. doi: 10.1128/MCB.00596-20.

Wang, H., Lu, J., Alencastro, F., Roberts, A., Fiedor, J., Carroll, P., Eisenman, R.N., Ranganathan, S., Torbenson, M., Duncan, A.W., & Prochownik, E.V. (2021). Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia. 2021.08.05.455215.Cold Spring Harbor Laboratory. doi: 10.1101/2021.08.05.455215.

Wilkinson, P.D., & Duncan, A.W. (2021). Differential Roles for Diploid and Polyploid Hepatocytes in Acute and Chronic Liver Injury. Semin Liver Dis, 41(1), 42-49.Thieme. doi: 10.1055/s-0040-1719175.

Duncan, A.W. (2020). Single-Cell and Bulk Transcriptome Profiling Reveals Unique Features of Diploid and Polyploid Hepatocytes. Cell Mol Gastroenterol Hepatol, 9(1), 193-194.Elsevier. doi: 10.1016/j.jcmgh.2019.09.008.

Duncan, A.W. (2020). Hepatocyte ploidy modulation in liver cancer. EMBO Rep, 21(12), e51922.Springer Nature. doi: 10.15252/embr.202051922.

Gliozzi, M.L., Espiritu, E.B., Shipman, K.E., Rbaibi, Y., Long, K.R., Roy, N., Duncan, A.W., Lazzara, M.J., Hukriede, N.A., Baty, C.J., & Weisz, O.A. (2020). Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model. J Am Soc Nephrol, 31(1), 67-83.Wolters Kluwer. doi: 10.1681/ASN.2019020125.

Stahl, E.C., Delgado, E.R., Alencastro, F., LoPresti, S.T., Wilkinson, P.D., Roy, N., Haschak, M.J., Skillen, C.D., Monga, S.P., Duncan, A.W., & Brown, B.N. (2020). Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2. Am J Pathol, 190(2), 372-387.Elsevier. doi: 10.1016/j.ajpath.2019.10.016.

Takeishi, K., Collin de l'Hortet, A., Wang, Y., Handa, K., Guzman-Lepe, J., Matsubara, K., Morita, K., Jang, S., Haep, N., Florentino, R.M., Yuan, F., Fukumitsu, K., Tobita, K., Sun, W., Franks, J., Delgado, E.R., Shapiro, E.M., Fraunhoffer, N.A., Duncan, A.W., Yagi, H., Mashimo, T., Fox, I.J., & Soto-Gutierrez, A. (2020). Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells. Cell Rep, 31(9), 107711.Elsevier. doi: 10.1016/j.celrep.2020.107711.

Xue, Y., Bhushan, B., Mars, W.M., Bowen, W., Tao, J., Orr, A., Stoops, J., Yu, Y., Luo, J., Duncan, A.W., & Michalopoulos, G.K. (2020). Phosphorylated Ezrin (Thr567) Regulates Hippo Pathway and Yes-Associated Protein (Yap) in Liver. Am J Pathol, 190(7), 1427-1437.Elsevier. doi: 10.1016/j.ajpath.2020.03.014.

Wilkinson, P.D., Alencastro, F., Delgado, E.R., Leek, M.P., Weirich, M.P., Otero, P.A., Roy, N., Brown, W.K., Oertel, M., & Duncan, A.W. (2019). Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury. Am J Pathol, 189(6), 1241-1255.Elsevier. doi: 10.1016/j.ajpath.2019.02.008.

Wilkinson, P.D., Delgado, E.R., Alencastro, F., Leek, M.P., Roy, N., Weirich, M.P., Stahl, E.C., Otero, P.A., Chen, M.I., Brown, W.K., & Duncan, A.W. (2019). The Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice. Hepatology, 69(3), 1242-1258.Wolters Kluwer. doi: 10.1002/hep.30286.

Wang, H., Dolezal, J.M., Kulkarni, S., Lu, J., Mandel, J., Jackson, L.E., Alencastro, F., Duncan, A.W., & Prochownik, E.V. (2018). Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice. J Biol Chem, 293(38), 14740-14757.Elsevier. doi: 10.1074/jbc.RA118.004099.

Jackson, L.E., Kulkarni, S., Wang, H., Lu, J., Dolezal, J.M., Bharathi, S.S., Ranganathan, S., Patel, M.S., Deshpande, R., Alencastro, F., Wendell, S.G., Goetzman, E.S., Duncan, A.W., & Prochownik, E.V. (2017). Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation. Cancer Res, 77(21), 5795-5807.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-17-1325.

Edmunds, L.R., Otero, P.A., Sharma, L., D'Souza, S., Dolezal, J.M., David, S., Lu, J., Lamm, L., Basantani, M., Zhang, P., Sipula, I.J., Li, L., Zeng, X., Ding, Y., Ding, F., Beck, M.E., Vockley, J., Monga, S.P.S., Kershaw, E.E., O'Doherty, R.M., Kratz, L.E., Yates, N.A., Goetzman, E.P., Scott, D., Duncan, A.W., & Prochownik, E.V. (2016). Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes. Oncotarget, 7(21), 30379-30395.Impact Journals. doi: 10.18632/oncotarget.8856.

Hsu, S.H., Delgado, E.R., Otero, P.A., Teng, K.Y., Kutay, H., Meehan, K.M., Moroney, J.B., Monga, J.K., Hand, N.J., Friedman, J.R., Ghoshal, K., & Duncan, A.W. (2016). MicroRNA-122 regulates polyploidization in the murine liver. Hepatology, 64(2), 599-615.Wolters Kluwer. doi: 10.1002/hep.28573.

Duncan, A.W. (2015). Changes in Hepatocyte Ploidy During Liver Regeneration. In Liver Regeneration. (pp. 167-184).Elsevier. doi: 10.1016/b978-0-12-420128-6.00012-9.

Hsu, S.H., & Duncan, A.W. (2015). Pathological polyploidy in liver disease. Hepatology, 62(3), 968-970.Wolters Kluwer. doi: 10.1002/hep.27908.

Duncan, A.W. (2013). Aneuploidy, polyploidy and ploidy reversal in the liver. Semin Cell Dev Biol, 24(4), 347-356.Elsevier. doi: 10.1016/j.semcdb.2013.01.003.

Duncan, A.W., & Soto-Gutierrez, A. (2013). Liver repopulation and regeneration: new approaches to old questions. Curr Opin Organ Transplant, 18(2), 197-202.Wolters Kluwer. doi: 10.1097/MOT.0b013e32835f07e2.

Kurinna, S., Stratton, S.A., Coban, Z., Schumacher, J.M., Grompe, M., Duncan, A.W., & Barton, M.C. (2013). p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology, 57(5), 2004-2013.Wolters Kluwer. doi: 10.1002/hep.26233.

Duncan, A.W., Hanlon Newell, A.E., Bi, W., Finegold, M.J., Olson, S.B., Beaudet, A.L., & Grompe, M. (2012). Aneuploidy as a mechanism for stress-induced liver adaptation. J Clin Invest, 122(9), 3307-3315.American Society for Clinical Investigation. doi: 10.1172/JCI64026.

Duncan, A.W., Hanlon Newell, A.E., Smith, L., Wilson, E.M., Olson, S.B., Thayer, M.J., Strom, S.C., & Grompe, M. (2012). Frequent aneuploidy among normal human hepatocytes. Gastroenterology, 142(1), 25-28.Elsevier. doi: 10.1053/j.gastro.2011.10.029.

Dorrell, C., Erker, L., Schug, J., Kopp, J.L., Canaday, P.S., Fox, A.J., Smirnova, O., Duncan, A.W., Finegold, M.J., Sander, M., Kaestner, K.H., & Grompe, M. (2011). Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev, 25(11), 1193-1203.Cold Spring Harbor Laboratory. doi: 10.1101/gad.2029411.

Duncan, A.W., Taylor, M.H., Hickey, R.D., Hanlon Newell, A.E., Lenzi, M.L., Olson, S.B., Finegold, M.J., & Grompe, M. (2010). The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature, 467(7316), 707-710.Springer Nature. doi: 10.1038/nature09414.

Zhang, Q.S., Marquez-Loza, L., Eaton, L., Duncan, A.W., Goldman, D.C., Anur, P., Watanabe-Smith, K., Rathbun, R.K., Fleming, W.H., Bagby, G.C., & Grompe, M. (2010). Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol. Blood, 116(24), 5140-5148.American Society of Hematology. doi: 10.1182/blood-2010-04-278226.

Duncan, A.W., Dorrell, C., & Grompe, M. (2009). Stem cells and liver regeneration. Gastroenterology, 137(2), 466-481.Elsevier. doi: 10.1053/j.gastro.2009.05.044.

Duncan, A.W., Hickey, R.D., Paulk, N.K., Culberson, A.J., Olson, S.B., Finegold, M.J., & Grompe, M. (2009). Ploidy reductions in murine fusion-derived hepatocytes. In Cohen-Fix, O. (Ed.). PLoS Genet, 5(2), e1000385.Public Library of Science (PLoS). doi: 10.1371/journal.pgen.1000385.

DiMascio, L., Voermans, C., Uqoezwa, M., Duncan, A., Lu, D., Wu, J., Sankar, U., & Reya, T. (2007). Identification of adiponectin as a novel hemopoietic stem cell growth factor. J Immunol, 178(6), 3511-3520.The American Association of Immunologists. doi: 10.4049/jimmunol.178.6.3511.

Duncan, A.W., Rattis, F.M., DiMascio, L.N., Congdon, K.L., Pazianos, G., Zhao, C., Yoon, K., Cook, J.M., Willert, K., Gaiano, N., & Reya, T. (2005). Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol, 6(3), 314-322.Springer Nature. doi: 10.1038/ni1164.

Kitsos, C.M., Sankar, U., Illario, M., Colomer-Font, J.M., Duncan, A.W., Ribar, T.J., Reya, T., & Means, A.R. (2005). Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. J Biol Chem, 280(39), 33101-33108.Elsevier. doi: 10.1074/jbc.M505208200.

Reya, T., Duncan, A.W., Ailles, L., Domen, J., Scherer, D.C., Willert, K., Hintz, L., Nusse, R., & Weissman, I.L. (2003). A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature, 423(6938), 409-414.Springer Nature. doi: 10.1038/nature01593.

Willert, K., Brown, J.D., Danenberg, E., Duncan, A.W., Weissman, I.L., Reya, T., Yates, J.R., & Nusse, R. (2003). Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature, 423(6938), 448-452.Springer Nature. doi: 10.1038/nature01611.

Cao, Y., Janssen, E.M., Duncan, A.W., Altman, A., Billadeau, D.D., & Abraham, R.T. (2002). Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J, 21(18), 4809-4819.Springer Nature. doi: 10.1093/emboj/cdf499.

BaSalamah, M.A., Marr, H.S., Duncan, A.W., & Edgell, C.J. (2001). Testican in human blood. Biochem Biophys Res Commun, 283(5), 1083-1090.Elsevier. doi: 10.1006/bbrc.2001.4900.

Marr, H.S., Basalamah, M.A., Bouldin, T.W., Duncan, A.W., & Edgell, C.J. (2000). Distribution of testican expression in human brain. Cell Tissue Res, 302(2), 139-144.Springer Nature. doi: 10.1007/s004410000277.