Alan Wells

Dai, B., Clark, A.M., & Wells, A. (2024). Mesenchymal Stem Cell-Secreted Exosomes and Soluble Signals Regulate Breast Cancer Metastatic Dormancy: Current Progress and Future Outlook. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(13), 7133.MDPI. doi: 10.3390/ijms25137133.

Marti, J.L.G., Wells, J.Z., & Wells, A. (2023). Statins as a Secondary Preventive Agent for Metastatic Cancer. JOURNAL OF THORACIC ONCOLOGY, 18(11), e125-e126.Elsevier. doi: 10.1016/j.jtho.2023.07.027.

Shao, H., Teramae, D., & Wells, A. (2023). Axl contributes to efficient migration and invasion of melanoma cells. In Chen, S. (Ed.). PLOS ONE, 18(3), e0283749.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0283749.

Gomez Marti, J.L., Brufsky, A., Wells, A., & Jiang, X. (2022). Machine Learning to Discern Interactive Clusters of Risk Factors for Late Recurrence of Metastatic Breast Cancer. CANCERS, 14(1), 253.MDPI. doi: 10.3390/cancers14010253.

Korentzelos, D., Wells, A., & Clark, A.M. (2022). Interferon-γ increases sensitivity to chemotherapy and provides immunotherapy targets in models of metastatic castration-resistant prostate cancer. SCIENTIFIC REPORTS, 12(1), 6657.Springer Nature. doi: 10.1038/s41598-022-10724-9.

Ma, B., Shao, H., Jiang, X., Wang, Z., Wu, C.C., Whaley, D., & Wells, A. (2022). Akt isoforms differentially provide for chemoresistance in prostate cancer. CANCER BIOLOGY & MEDICINE, 19(5), 635-650.China Anti-cancer Association. doi: 10.20892/j.issn.2095-3941.2020.0747.

Phan, T., Boes, S., McCullough, M., Gribschaw, J., & Wells, A. (2022). Development of the one-step qualitative RT-PCR assay to detect SARS-CoV-2 Omicron (B.1.1.529) variant in respiratory specimens. In medRxiv. doi: 10.1101/2022.01.04.22268772.

Popescu, I., Snyder, M.E., Iasella, C.J., Hannan, S.J., Koshy, R., Burke, R., Das, A., Brown, M.J., Lyons, E.J., Lieber, S.C., Chen, X., Sembrat, J.C., Bhatt, P., Deng, E., An, X., Linstrum, K., Kitsios, G., Konstantinidis, I., Saul, M., Kass, D.J., Alder, J.K., Chen, B.B., Lendermon, E.A., Kilaru, S., Johnson, B., Pilewski, J.M., Kiss, J.E., Wells, A.H., Morris, A., McVerry, B.J., McMahon, D.K., Triulzi, D.J., Chen, K., Sanchez, P.G., & McDyer, J.F. (2022). CD4⁺ T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1-Dependent. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 205(12), 1403-1418.American Thoracic Society. doi: 10.1164/rccm.202111-2493OC.

Shao, H., Teramae, D., & Wells, A. (2022). Axl contributes to efficient migration and invasion of melanoma cells. In bioRxiv. doi: 10.1101/2022.05.02.490307.

Sylakowski, K., Hwang, M.P., Justin, A., Whaley, D., Wang, Y., & Wells, A. (2022). The matricellular protein decorin delivered intradermally with coacervate improves wound resolution in the CXCR3-deficient mouse model of hypertrophic scarring. WOUND REPAIR AND REGENERATION, 30(4), 436-447.Wiley. doi: 10.1111/wrr.13017.

Sylakowski, K., Hwang, P., Justin, A., Shao, H., Whaley, D., Wang, Y., & Wells, A. (2022). Matricellular protein Tenascin-C enhances mesenchymal stem cell angiogenic and wound healing efficacy under ischemic conditions. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 16(12), 1249-1260.Hindawi. doi: 10.1002/term.3367.

Wells, A., Wang, Y., Shao, H., Sohnen, P., & Swamynathan, S.K. (2022). A CXCR3-activating peptide increases Tear Break Up Time and corrects corneal haze in a rabbit model of environmental dry eye. In bioRxiv. doi: 10.1101/2022.12.07.519513.

Zhu, L., Marsh, J.W., Griffith, M.P., Collins, K., Srinivasa, V., Waggle, K., Van Tyne, D., Snyder, G.M., Phan, T., Wells, A., Marroquin, O.C., & Harrison, L.H. (2022). Predictive model for severe COVID-19 using SARS-CoV-2 whole-genome sequencing and electronic health record data, March 2020-May 2021. In Novelli, G. (Ed.). PLOS ONE, 17(7), e0271381.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0271381.

Agha, M., Blake, M., Chilleo, C., Wells, A., & Haidar, G. (2021). Suboptimal response to COVID-19 mRNA vaccines in hematologic malignancies patients. medRxiv, 2(04-13), 2021.04.06.21254949.Cold Spring Harbor Laboratory. doi: 10.1101/2021.04.06.21254949.

Clark, A.M., Allbritton, N.L., & Wells, A. (2021). Integrative microphysiological tissue systems of cancer metastasis to the liver. SEMINARS IN CANCER BIOLOGY, 71, 157-169.Elsevier. doi: 10.1016/j.semcancer.2020.06.010.

Clark, A.M., Heusey, H.L., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2021). IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment. FRONTIERS IN ONCOLOGY, 11, 676135.Frontiers. doi: 10.3389/fonc.2021.676135.

Haidar, G., Ayres, A., King, W.C., McDonald, M., Wells, A., Mitchell, S.L., Bilderback, A.L., Minnier, T., & Mellors, J.W. (2021). Preprocedural SARS-CoV-2 Testing to Sustain Medically Needed Health Care Delivery During the COVID-19 Pandemic: A Prospective Observational Study. OPEN FORUM INFECTIOUS DISEASES, 8(2), ofab022.Oxford University Press (OUP). doi: 10.1093/ofid/ofab022.

Huang, D.T., McCreary, E.K., Bariola, J.R., Wadas, R.J., Kip, K.E., Marroquin, O.C., Koscumb, S., Collins, K., Shovel, J.A., Schmidhofer, M., Wisniewski, M.K., Sullivan, C., Yealy, D.M., Axe, M., Nace, D.A., Haidar, G., Khadem, T., Linstrum, K., Snyder, G.M., Seymour, C.W., Montgomery, S.K., McVerry, B.J., Berry, L., Berry, S., Meyers, R., Weissman, A., Peck-Palmer, O.M., Wells, A., Bart, R., Albin, D.L., Minnier, T., & Angus, D.C. (2021). The UPMC OPTIMISE-C19 (OPtimizing Treatment and Impact of Monoclonal antIbodieS through Evaluation for COVID-19) trial: a structured summary of a study protocol for an open-label, pragmatic, comparative effectiveness platform trial with response-adaptive randomization. TRIALS, 22(1), 363.Springer Nature. doi: 10.1186/s13063-021-05316-3.

Ma, B., Wells, A., Wei, L., & Zheng, J. (2021). Prostate cancer liver metastasis: Dormancy and resistance to therapy. SEMINARS IN CANCER BIOLOGY, 71, 2-9.Elsevier. doi: 10.1016/j.semcancer.2020.07.004.

Marti, J.L.G., Beckwitt, C.H., Clark, A.M., & Wells, A. (2021). Atorvastatin facilitates chemotherapy effects in metastatic triple-negative breast cancer. BRITISH JOURNAL OF CANCER, 125(9), 1285-1298.Springer Nature. doi: 10.1038/s41416-021-01529-0.

Marti, J.L.G., Brufsky, A., Wells, A., & Jiang, X. (2021). Machine-Learning to Discern Interactive Clusters of Risk Factors for Late Recurrence of Metastatic Breast Cancer. In Preprints.org. doi: 10.20944/preprints202112.0018.v1.

Marti, J.L.G., Mays, A., McCullough, M., Wells, A., & Phan, T. (2021). Evaluation of viral loads in patients with SARS-CoV-2 Delta variant infection: Higher loads do not translate into different testing scenarios. In medRxiv. doi: 10.1101/2021.10.14.21265031.

Marti, J.L.G., Wells, A., & Brufsky, A.M. (2021). Dysregulation of the mevalonate pathway during SARS-CoV-2 infection: An in silico study. JOURNAL OF MEDICAL VIROLOGY, 93(4), 2396-2405.Wiley. doi: 10.1002/jmv.26743.

Nace, D.A., Kip, K.E., Palmer, O.M.P., Shurin, M.R., Mulvey, K., Crandall, M., Kane, A.L., Lukanski, A., Kip, P.L., & Wells, A.L. (2021). Antibody Responses in Elderly Residential Care Persons following COVID-19 mRNA Vaccination. In medRxiv. doi: 10.1101/2021.04.07.21254925.

Phan, T., Mays, A., McCullough, M., & Wells, A. (2021). Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 test for bronchoalveolar lavage. In medRxiv. doi: 10.1101/2021.12.21.21268190.

Popescu, I., Snyder, M.E., Iasella, C.J., Hannan, S.J., Koshy, R., Burke, R., Das, A., Brown, M.J., Lyons, E.J., Lieber, S.C., Chen, X., Sembrat, J.C., An, X., Linstrum, K., Kitsios, G., Konstantinidis, I., Saul, M., Kass, D.J., Alder, J.K., Chen, B.B., Lendermon, E.A., Kilaru, S., Johnson, B., Morrell, M.R., Pilewski, J.M., Kiss, J.E., Wells, A.H., Morris, A., McVerry, B.J., McMahon, D.K., Triulzi, D.J., Chen, K., Sanchez, P.G., & McDyer, J.F. (2021). CD4+ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent. 2021.06.02.446831.Cold Spring Harbor Laboratory. doi: 10.1101/2021.06.02.446831.

Shao, H., & Wells, A. (2021). Binding of alpha-ACTN4 to EGF receptor enables its rapid phosphorylation. HELIYON, 7(1), e06011.Elsevier. doi: 10.1016/j.heliyon.2021.e06011.

Swogger, J., Conner, I.P., Happ-Smith, C., Kemmerer, M.C., Julian, D.R., Wells, A., Schuman, J.S., Yates, C.C., & Davis, R. (2021). Novel combination therapy reduces subconjunctival fibrosis after glaucoma filtration surgery in the rabbit model. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 49(1), 60-69.Wiley. doi: 10.1111/ceo.13884.

Sylakowski, K., & Wells, A. (2021). ECM-regulation of autophagy: The yin and the yang of autophagy during wound healing. MATRIX BIOLOGY, 100, 197-206.Elsevier. doi: 10.1016/j.matbio.2020.12.006.

Wells, A., Beckwitt, C., & Marti, J.L.G. (2021). Preventing metastatic emergence of breast cancer. AGING-US, 13(19), 22627-22628.Impact Journals. doi: 10.18632/aging.203631.

Xu, L., Doyle, J., Barbeau, D.J., Le Sage, V., Wells, A., Duprex, W.P., Shurin, M.R., Wheeler, S.E., & McElroy, A.K. (2021). A Cross-Sectional Study of SARS-CoV-2 Seroprevalence between Fall 2020 and February 2021 in Allegheny County, Western Pennsylvania, USA. PATHOGENS, 10(6), 710.MDPI. doi: 10.3390/pathogens10060710.

Zilla, M., Wheeler, B.J., Keetch, C., Mitchell, G., McBreen, J., Wells, A., Shurin, M.R., Peck-Palmer, O., & Wheeler, S.E. (2021). Variable Performance in 6 Commercial SARS-CoV-2 Antibody Assays May Affect Convalescent Plasma and Seroprevalence Screening. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 155(3), 343-353.Oxford University Press (OUP). doi: 10.1093/AJCP/AQAA228.

Jiang, X., Wells, A., Brufsky, A., Shetty, D., Shajihan, K., & Neapolitan, R.E. (2020). Leveraging Bayesian networks and information theory to learn risk factors for breast cancer metastasis. BMC BIOINFORMATICS, 21(1), 298.Springer Nature. doi: 10.1186/s12859-020-03638-8.

Klimstra, W.B., Tilston-Lunel, N.L., Nambulli, S., Boslett, J., McMillen, C.M., Gilliland, T., Dunn, M.D., Sun, C., Wheeler, S.E., Wells, A., Hartman, A.L., McElroy, A.K., Reed, D.S., Rennick, L.J., & Duprex, W.P. (2020). SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients. JOURNAL OF GENERAL VIROLOGY, 101(11), 1156-1169.Microbiology Society. doi: 10.1099/jgv.0.001481.

Korentzelos, D., Clark, A.M., & Wells, A. (2020). A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(19), 7304.MDPI. doi: 10.3390/ijms21197304.

Ma, B., Wells, A., & Clark, A.M. (2020). The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment. SEMINARS IN CANCER BIOLOGY, 60, 138-147.Elsevier. doi: 10.1016/j.semcancer.2019.07.021.

Shurin, M.R., Morris, A., Wells, A., & Wheeler, S.E. (2020). Assessing Immune Response to SARS-CoV-2 Infection. IMMUNOTARGETS AND THERAPY, 9, 111-114.Taylor & Francis. doi: 10.2147/ITT.S264138.

Swamynathan, S.K., & Wells, A. (2020). Conjunctival goblet cells: Ocular surface functions, disorders that affect them, and the potential for their regeneration. OCULAR SURFACE, 18(1), 19-26.Elsevier. doi: 10.1016/j.jtos.2019.11.005.

Swogger, J., Conner, I.P., Rosano, M., Kemmerer, M., Happ-Smith, C., Wells, A., Schuman, J.S., & Yates, C.C. (2020). Injected Versus Sponge-Applied Mitomycin C (MMC) During Modified Trabeculectomy in New Zealand White Rabbit Model. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 9(11), 23.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/tvst.9.11.23.

Sylakowski, K., Bradshaw, A., & Wells, A. (2020). Mesenchymal Stem Cell/Multipotent Stromal Cell Augmentation of Wound Healing Lessons from the Physiology of Matrix and Hypoxia Support. AMERICAN JOURNAL OF PATHOLOGY, 190(7), 1370-1381.Elsevier. doi: 10.1016/j.ajpath.2020.03.017.

Jiang, X., Wells, A., Brufsky, A., & Neapolitan, R. (2019). A clinical decision support system learned from data to personalize treatment recommendations towards preventing breast cancer metastasis. In Jeong, J. (Ed.). PLOS ONE, 14(3), e0213292.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0213292.

Jiang, Y., Wells, A., Sylakowski, K., Clark, A.M., & Ma, B. (2019). Adult Stem Cell Functioning in the Tumor Micro-Environment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(10), 2566.MDPI. doi: 10.3390/ijms20102566.

Ma, B., Khazali, M., Shao, H., Jiang, Y., & Wells, A. (2019). Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer. CELL COMMUNICATION AND SIGNALING, 17(1), 164.Springer Nature. doi: 10.1186/s12964-019-0489-1.

Shao, H., Wingert, B., Weins, A., Pollak, M.R., Camacho, C., & Wells, A. (2019). Focal segmental glomerulosclerosis ACTN4 mutants binding to actin: regulation by phosphomimetic mutations. SCIENTIFIC REPORTS, 9(1), 15517.Springer Nature. doi: 10.1038/s41598-019-51825-2.

Beckwitt, C.H., Brufsky, A., Oltvai, Z.N., & Wells, A. (2018). Statin drugs to reduce breast cancer recurrence and mortality. BREAST CANCER RESEARCH, 20(1), 144.Springer Nature. doi: 10.1186/s13058-018-1066-z.

Beckwitt, C.H., Clark, A.M., Ma, B., Whaley, D., Oltvai, Z.N., & Wells, A. (2018). Statins attenuate outgrowth of breast cancer metastases. BRITISH JOURNAL OF CANCER, 119(9), 1094-1105.Springer Nature. doi: 10.1038/s41416-018-0267-7.

Beckwitt, C.H., Clark, A.M., Wheeler, S., Taylor, D.L., Stolz, D.B., Griffith, L., & Wells, A. (2018). Liver 'organ on a chip'. EXPERIMENTAL CELL RESEARCH, 363(1), 15-25.Elsevier. doi: 10.1016/j.yexcr.2017.12.023.

Beckwitt, C.H., Shiraha, K., & Wells, A. (2018). Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling. In Ghavami, S. (Ed.). PLOS ONE, 13(5), e0197422.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0197422.

Bradshaw, A., Sylakowski, K., & Wells, A. (2018). The Pro-reparative Engine: Stem Cells Aid Healing by Dampening Inflammation. Current Pathobiology Reports, 6(2), 109-115.Springer Nature. doi: 10.1007/s40139-018-0167-9.

Clark, A.M., Kumar, M.P., Wheeler, S.E., Young, C.L., Venkataramanan, R., Stolz, D.B., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2018). A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. MOLECULAR & CELLULAR PROTEOMICS, 17(4), 619-630.Elsevier. doi: 10.1074/mcp.RA117.000370.

Ishikawa, T., Hosaka, Y.Z., Beckwitt, C., Wells, A., Oltvai, Z.N., & Warita, K. (2018). Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics. Oncotarget, 9(50), 29304-29315.Impact Journals. doi: 10.18632/oncotarget.25448.

Khazali, A.S., Clark, A.M., & Wells, A. (2018). Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy. BRITISH JOURNAL OF CANCER, 118(4), 566-576.Springer Nature. doi: 10.1038/bjc.2017.414.

Raghu, V.K., Beckwitt, C.H., Warita, K., Wells, A., Benos, P.V., & Oltvai, Z.N. (2018). Biomarker identification for statin sensitivity of cancer cell lines. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 495(1), 659-665.Elsevier. doi: 10.1016/j.bbrc.2017.11.065.

Stram, M.N., Suciu, C.N., Seheult, J.N., McCullough, M.A., Kader, M., Wells, A., Pasculle, A.W., Rinaldo, C.R., & Ismail, N. (2018). Herpes Simplex Virus-1 qPCR in the Diagnosis of Lower Respiratory Tract Infections in Organ Transplant Recipients and Critically Ill Patients. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 150(6), 522-532.Oxford University Press (OUP). doi: 10.1093/AJCP/AQY088.

Wells, A., & Wiley, H.S. (2018). A systems perspective of heterocellular signaling. SYSTEMS BIOLOGY, 62(4), 607-617.Portland Press. doi: 10.1042/EBC20180015.

Wells, A., Clark, A., Bradshaw, A., Ma, B., & Edington, H. (2018). The great escape: How metastases of melanoma, and other carcinomas, avoid elimination. EXPERIMENTAL BIOLOGY AND MEDICINE, 243(17-18), 1245-1255.Frontiers. doi: 10.1177/1535370218820287.

Zeng, Z., Jiang, X., Li, X., Wells, A., Luo, Y., & Neapolitan, R. (2018). Conjugated equine estrogen and medroxyprogesterone acetate are associated with decreased risk of breast cancer relative to bioidentical hormone therapy and controls. In Härkönen, P.L. (Ed.). PLOS ONE, 13(5), e0197064.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0197064.

Clark, A.M., Wheeler, S.E., Young, C.L., Stockdale, L., Neiman, J.S., Zhao, W., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2017). A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. LAB ON A CHIP, 17(1), 156-168.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc01171c.

Dioufa, N., Clark, A.M., Ma, B., Beckwitt, C.H., & Wells, A. (2017). Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. MOLECULAR CANCER, 16(1), 172.Springer Nature. doi: 10.1186/s12943-017-0740-6.

Gonzalez, A., Garcia de Durango, C., Alonso, V., Bravo, B., Rodriguez de Gortazar, A., Wells, A., Forteza, J., & Vidal-Vanaclocha, F. (2017). Distinct Osteomimetic Response of Androgen-Dependent and Independent Human Prostate Cancer Cells to Mechanical Action of Fluid Flow: Prometastatic Implications. PROSTATE, 77(3), 321-333.Wiley. doi: 10.1002/pros.23270.

Kader, M., Alaoui-EL-Azher, M., Vorhauer, J., Kode, B.B., Wells, J.Z., Stolz, D., Michalopoulos, G., Wells, A., Scott, M., & Ismail, N. (2017). MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. In Coers, J. (Ed.). PLOS PATHOGENS, 13(10), e1006644.Public Library of Science (PLoS). doi: 10.1371/journal.ppat.1006644.

Khazali, A.S., Clark, A.M., & Wells, A. (2017). A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms. STEM CELL REVIEWS AND REPORTS, 13(3), 364-380.Springer Nature. doi: 10.1007/s12015-017-9735-3.

Raghu, V.K., Beckwitt, C.H., Warita, K., Wells, A., Benos, P.V., & Oltvai, Z.N. (2017). Biomarker identification for statin sensitivity of cancer cell lines. In bioRxiv. doi: 10.1101/215756.

Shao, H., Lauffenburger, D., & Wells, A. (2017). Tyro3 carboxyl terminal region confers stability and contains the autophosphorylation sites. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 490(3), 1074-1079.Elsevier. doi: 10.1016/j.bbrc.2017.06.168.

Wells, A., & Ma, B. (2017). Friend turned foe: E-cadherin perversely protects micrometastases. TRANSLATIONAL ANDROLOGY AND UROLOGY, 6(2), 338-340.AME Publishing Company. doi: 10.21037/tau.2017.03.25.

Yates, C.C., Nuschke, A., Rodrigues, M., Whaley, D., Dechant, J.J., Taylor, D.P., & Wells, A. (2017). Improved Transplanted Stem Cell Survival in a Polymer Gel Supplemented With Tenascin C Accelerates Healing and Reduces Scarring of Murine Skin Wounds. CELL TRANSPLANTATION, 26(1), 103-113.SAGE Publications. doi: 10.3727/096368916X692249.

Yates, C.C., Rodrigues, M., Nuschke, A., Johnson, Z.I., Whaley, D., Stolz, D., Newsome, J., & Wells, A. (2017). Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring. STEM CELL RESEARCH & THERAPY, 8(1), 193.Springer Nature. doi: 10.1186/s13287-017-0644-9.

Bodnar, R.J., Satish, L., Yates, C.C., & Wells, A. (2016). Pericytes: A newly recognized player in wound healing. WOUND REPAIR AND REGENERATION, 24(2), 204-214.Wiley. doi: 10.1111/wrr.12415.

Clark, A.M., Ma, B., Taylor, D.L., Griffith, L., & Wells, A. (2016). Liver metastases: Microenvironments and ex-vivo models. EXPERIMENTAL BIOLOGY AND MEDICINE, 241(15), 1639-1652.Frontiers. doi: 10.1177/1535370216658144.

Gordonov, S., Hwang, M.K., Wells, A., Gertler, F.B., Lauffenburger, D.A., & Bathe, M. (2016). Time series modeling of live-cell shape dynamics for image-based phenotypic profiling. INTEGRATIVE BIOLOGY, 8(1), 73-90.Oxford University Press (OUP). doi: 10.1039/c5ib00283d.

Huen, A.C., Marathi, A., Nam, P.K., & Wells, A. (2016). CXCL11 Expression by Keratinocytes Occurs Transiently Between Reaching Confluence and Cellular Compaction. ADVANCES IN WOUND CARE, 5(12), 517-526.Mary Ann Liebert. doi: 10.1089/wound.2015.0680.

Ma, B., Wheeler, S.E., Clark, A.M., Whaley, D.L., Yang, M., & Wells, A. (2016). Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling. HEPATOLOGY, 64(5), 1725-1742.Wolters Kluwer. doi: 10.1002/hep.28755.

Nuschke, A., Rodrigues, M., Rivera, J., Yates, C., Whaley, D., Stolz, D., Griffith, L., & Wells, A. (2016). Epidermal Growth Factor Tethered to β-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. STEM CELLS TRANSLATIONAL MEDICINE, 5(11), 1580-1586.Oxford University Press (OUP). doi: 10.5966/sctm.2015-0326.

Nuschke, A., Rodrigues, M., Wells, A.W., Sylakowski, K., & Wells, A. (2016). Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation. STEM CELL RESEARCH & THERAPY, 7(1), 179.Springer Nature. doi: 10.1186/s13287-016-0436-7.

Wells, A., Nuschke, A., & Yates, C.C. (2016). Skin tissue repair: Matrix microenvironmental influences. MATRIX BIOLOGY, 49, 25-36.Elsevier. doi: 10.1016/j.matbio.2015.08.001.

Yang, M., Ma, B., Shao, H., Clark, A.M., & Wells, A. (2016). Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. BMC CANCER, 16(1), 419.Springer Nature. doi: 10.1186/s12885-016-2411-1.

Bodnar, R.J., & Wells, A. (2015). Differential regulation of pericyte function by the CXC receptor 3. WOUND REPAIR AND REGENERATION, 23(6), 785-796.Wiley. doi: 10.1111/wrr.12346.

Furukawa, M., Wheeler, S., Clark, A.M., & Wells, A. (2015). Lung Epithelial Cells Induce Both Phenotype Alteration and Senescence in Breast Cancer Cells. In Samant, R. (Ed.). PLOS ONE, 10(1), e0118060.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0118060.

Ma, B., Khazali, A., & Wells, A. (2015). CXCR3 in carcinoma progression. HISTOLOGY AND HISTOPATHOLOGY, 30(7), 781-792. doi: 10.14670/HH-11-594.

Richard, S., Wells, A., Connor, J., & Price, F. (2015). Use of ChemoFx® for Identification of Effective Treatments in Epithelial Ovarian Cancer. PLOS Currents, 7(Evidence on Genomic Tests), ecurrents.eogt.8b0b6fffc7b999b34bc4c8152edbf237.Public Library of Science (PLoS). doi: 10.1371/currents.eogt.8b0b6fffc7b999b34bc4c8152edbf237.

Shao, H., Kirkwood, J.M., & Wells, A. (2015). Tenascin-C Signaling in melanoma. CELL ADHESION & MIGRATION, 9(1-2), 125-130.Taylor & Francis. doi: 10.4161/19336918.2014.972781.

Travers, T., Shao, H., Joughin, B.A., Lauffenburger, D.A., Wells, A., & Camacho, C.J. (2015). Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function. SCIENCE SIGNALING, 8(378), ra51.American Association for the Advancement of Science (AAAS). doi: 10.1126/scisignal.aaa1977.

Clark, A.M., Wheeler, S.E., Taylor, D.P., Pillai, V.C., Young, C.L., Prantil-Baun, R., Transon, N., Stolz, D.B., Borenstein, J.T., Lauffenburger, D.A., Venkataramanan, R., Griffith, L.G., & Wells, A. (2014). A microphysiological system model of therapy for liver micrometastases. EXPERIMENTAL BIOLOGY AND MEDICINE, 239(9), 1170-1179.Frontiers. doi: 10.1177/1535370214532596.

Ding, Z., Joy, M., Bhargava, R., Gunsaulus, M., Lakshman, N., Miron-Mendoza, M., Petroll, M., Condeelis, J., Wells, A., & Roy, P. (2014). Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis. ONCOGENE, 33(16), 2065-2074.Springer Nature. doi: 10.1038/onc.2013.166.

Grahovac, J., & Wells, A. (2014). Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion. LABORATORY INVESTIGATION, 94(1), 31-40.Elsevier. doi: 10.1038/labinvest.2013.132.

Griffith, L.G., Wells, A., & Stolz, D.B. (2014). Engineering Liver. HEPATOLOGY, 60(4), 1426-1434.Wolters Kluwer. doi: 10.1002/hep.27150.

Jamison, J., Wang, J.H.C., & Wells, A. (2014). PKCδ Regulates Force Signaling during VEGF/CXCL4 Induced Dissociation of Endothelial Tubes. In Hotchin, N.A. (Ed.). PLOS ONE, 9(4), e93968.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0093968.

Ma, B., & Wells, A. (2014). The Mitogen-activated Protein ( MAP) Kinases p38 and Extracellular Signal-regulated Kinase ( ERK) Are Involved in Hepatocyte-mediated Phenotypic Switching in Prostate Cancer Cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(16), 11153-11161.Elsevier. doi: 10.1074/jbc.M113.540237.

Nuschke, A., Rodrigues, M., Stolz, D.B., Chu, C.T., Griffith, L., & Wells, A. (2014). Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation. STEM CELL RESEARCH & THERAPY, 5(6), 140.Springer Nature. doi: 10.1186/scrt530.

Shao, H., Li, S., Watkins, S.C., & Wells, A. (2014). α-Actinin-4 Is Required for Amoeboid-type Invasiveness of Melanoma Cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(47), 32717-32728.Elsevier. doi: 10.1074/jbc.M114.579185.

Taylor, D.P., Clark, A., Wheeler, S., & Wells, A. (2014). Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. BREAST CANCER RESEARCH AND TREATMENT, 144(3), 551-560.Springer Nature. doi: 10.1007/s10549-014-2875-0.

Warita, K., Warita, T., Beckwitt, C.H., Schurdak, M.E., Vazquez, A., Wells, A., & Oltvai, Z.N. (2014). Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. SCIENTIFIC REPORTS, 4(1), 7593.Springer Nature. doi: 10.1038/srep07593.

Wheeler, S.E., Clark, A.M., Taylor, D.P., Young, C.L., Pillai, V.C., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2014). Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system. BRITISH JOURNAL OF CANCER, 111(12), 2342-2350.Springer Nature. doi: 10.1038/bjc.2014.533.

Bodnar, R.J., Rodgers, M.E., Chen, W.C.W., & Wells, A. (2013). Pericyte Regulation of Vascular Remodeling Through the CXC Receptor 3. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(12), 2818-2829.Wolters Kluwer. doi: 10.1161/ATVBAHA.113.302012.

Grahovac, J., Becker, D., & Wells, A. (2013). Melanoma Cell Invasiveness Is Promoted at Least in Part by the Epidermal Growth Factor-Like Repeats of Tenascin-C. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133(1), 210-220.Elsevier. doi: 10.1038/jid.2012.263.

Hang, T.C., Tedford, N.C., Reddy, R.J., Rimchala, T., Wells, A., White, F.M., Kamm, R.D., & Lauffenburger, D.A. (2013). Vascular Endothelial Growth Factor (VEGF) and Platelet (PF-4) Factor 4 Inputs Modulate Human Microvascular Endothelial Signaling in a Three-Dimensional Matrix Migration Context. MOLECULAR & CELLULAR PROTEOMICS, 12(12), 3704-3718.Elsevier. doi: 10.1074/mcp.M113.030528.

Jamison, J., Lauffenburger, D., Wang, J.C.H., & Wells, A. (2013). PKCδ Localization at the Membrane Increases Matrix Traction Force Dependent on PLCγ1/EGFR Signaling. In Parsons, M. (Ed.). PLOS ONE, 8(10), e77434.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0077434.

Rodrigues, M., Blair, H., Stockdale, L., Griffith, L., & Wells, A. (2013). Surface Tethered Epidermal Growth Factor Protects Proliferating and Differentiating Multipotential Stromal Cells from FasL-Induced Apoptosis. STEM CELLS, 31(1), 104-116.Oxford University Press (OUP). doi: 10.1002/stem.1215.

Rodrigues, M., Yates, C.C., Nuschke, A., Griffith, L., & Wells, A. (2013). The Matrikine Tenascin-C Protects Multipotential Stromal Cells/Mesenchymal Stem Cells from Death Cytokines Such as FasL. TISSUE ENGINEERING PART A, 19(17-18), 1972-1983.Mary Ann Liebert. doi: 10.1089/ten.tea.2012.0568.

Shao, H., Travers, T., Camacho, C.J., & Wells, A. (2013). The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 45(6), 1051-1063.Elsevier. doi: 10.1016/j.biocel.2013.02.015.

Taylor, D.P., Wells, J.Z., Savol, A., Chennubhotla, C., & Wells, A. (2013). Modeling Boundary Conditions for Balanced Proliferation in Metastatic Latency. CLINICAL CANCER RESEARCH, 19(5), 1063-1070.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-12-3180.

Travers, T., Shao, H., Wells, A., & Camacho, C.J. (2013). Modeling the Assembly of the Multiple Domains of α-actinin-4 and Its Role in Actin Cross-linking. BIOPHYSICAL JOURNAL, 104(3), 705-715.Elsevier. doi: 10.1016/j.bpj.2012.12.003.

Wells, A., Grahovac, J., Wheeler, S., Ma, B., & Lauffenburger, D. (2013). Targeting tumor cell motility as a strategy against invasion and metastasis. TRENDS IN PHARMACOLOGICAL SCIENCES, 34(5), 283-289.Elsevier. doi: 10.1016/j.tips.2013.03.001.

Wells, A., Griffith, L., Wells, J.Z., & Taylor, D.P. (2013). The Dormancy Dilemma: Quiescence versus Balanced Proliferation. CANCER RESEARCH, 73(13), 3811-3816.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-13-0356.

Wheeler, S.E., Borenstein, J.T., Clark, A.M., Ebrahimkhani, M., Fox, I.J., Griffith, L., Inman, W., Lauffenburger, D., Transon, N., Pillai, V.C., Prantil-Baun, R., Stolz, D.B., Taylor, D., Ulrich, T., Venkataramanan, R., Wells, A., & Young, C. (2013). All-human microphysical model of metastasis therapy. STEM CELL RESEARCH & THERAPY, 4(Suppl 1), s11.Springer Nature. doi: 10.1186/scrt372.

Chao, Y., Wu, Q., Acquafondata, M., Dhir, R., & Wells, A. (2012). Partial Mesenchymal to Epithelial Reverting Transition in Breast and Prostate Cancer Metastases. Cancer Microenvironment, 5(1), 19-28.Springer Nature. doi: 10.1007/s12307-011-0085-4.

Chao, Y., Wu, Q., Shepard, C., & Wells, A. (2012). Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance. CLINICAL & EXPERIMENTAL METASTASIS, 29(1), 39-50.Springer Nature. doi: 10.1007/s10585-011-9427-3.

Gunasinghe, N.P.A.D., Wells, A., Thompson, E.W., & Hugo, H.J. (2012). Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer. CANCER AND METASTASIS REVIEWS, 31(3-4), 469-478.Springer Nature. doi: 10.1007/s10555-012-9377-5.

Jones, J., Wang, H., Zhou, J., Hardy, S., Turner, T., Austin, D., He, Q., Wells, A., Grizzle, W.E., & Yates, C. (2012). Nuclear Kaiso Indicates Aggressive Prostate Cancers and Promotes Migration and Invasiveness of Prostate Cancer Cells. AMERICAN JOURNAL OF PATHOLOGY, 181(5), 1836-1846.Elsevier. doi: 10.1016/j.ajpath.2012.08.008.

Meyer, A.S., Hughes-Alford, S.K., Kay, J.E., Castillo, A., Wells, A., Gertler, F.B., & Lauffenburger, D.A. (2012). 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. JOURNAL OF CELL BIOLOGY, 197(6), 721-729.Rockefeller University Press. doi: 10.1083/jcb.201201003.

Park, S., Pantanowitz, L., Parwani, A.V., Wells, A., & Oltvai, Z.N. (2012). Workflow Organization in Pathology. CLINICS IN LABORATORY MEDICINE, 32(4), 601-+.Elsevier. doi: 10.1016/j.cll.2012.07.008.

Rodrigues, M., Turner, O., Stolz, D., Griffith, L.G., & Wells, A. (2012). Production of Reactive Oxygen Species by Multipotent Stromal Cells/Mesenchymal Stem Cells Upon Exposure to Fas Ligand. CELL TRANSPLANTATION, 21(10), 2171-2187.SAGE Publications. doi: 10.3727/096368912X639035.

Wells, A. (2012). Laboratory medicine: a view to the future of diagnostics and training. Journal of Japanese Society of Laboratory Medicine, 60(4), 312-320.

Wells, A., & Oltvai, Z.N. (2012). Conceptual Advances in Pathology Preface. CLINICS IN LABORATORY MEDICINE, 32(4), IX-X.Elsevier. doi: 10.1016/j.cll.2012.07.007.

Wu, Q., Dhir, R., & Wells, A. (2012). Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion. MOLECULAR CANCER, 11(1), 3.Springer Nature. doi: 10.1186/1476-4598-11-3.

Yates, C.C., Hebda, P., & Wells, A. (2012). Skin Wound Healing and Scarring: Fetal Wounds and Regenerative Restitution. BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS, 96(4), 325-333.Wiley. doi: 10.1002/bdrc.21024.

Yates, C.C., Whaley, D., & Wells, A. (2012). Transplanted Fibroblasts Prevents Dysfunctional Repair in a Murine CXCR3-Deficient Scarring Model. CELL TRANSPLANTATION, 21(5), 919-931.SAGE Publications. doi: 10.3727/096368911X623817.

Yates-Binder, C.C., Rodgers, M., Jaynes, J., Wells, A., Bodnar, R.J., & Turner, T. (2012). An IP-10 (CXCL10)-Derived Peptide Inhibits Angiogenesis. In Proost, P. (Ed.). PLOS ONE, 7(7), e40812.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0040812.

Kim, H.D., Meyer, A.S., Wagner, J.P., Alford, S.K., Wells, A., Gertler, F.B., & Lauffenburger, D.A. (2011). Signaling Network State Predicts Twist-Mediated Effects on Breast Cell Migration Across Diverse Growth Factor Contexts. MOLECULAR & CELLULAR PROTEOMICS, 10(11), m111.008433.Elsevier. doi: 10.1074/mcp.M111.008433.

Leloup, L., & Wells, A. (2011). Calpains as potential anti-cancer targets. EXPERT OPINION ON THERAPEUTIC TARGETS, 15(3), 309-323.Taylor & Francis. doi: 10.1517/14728222.2011.553611.

Meran, S., Luo, D.D., Simpson, R., Martin, J., Wells, A., Steadman, R., & Phillips, A.O. (2011). Hyaluronan Facilitates Transforming Growth Factor-β1-dependent Proliferation via CD44 and Epidermal Growth Factor Receptor Interaction. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(20), 17618-17630.Elsevier. doi: 10.1074/jbc.M111.226563.

Wells, A., Chao, Y.L., Grahovac, J., Wu, Q., & Lauffenburger, D.A. (2011). Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. FRONTIERS IN BIOSCIENCE-LANDMARK, 16(3), 815-837.IMR Press. doi: 10.2741/3722.

Wu, S., Wells, A., Griffith, L.G., & Lauffenburger, D.A. (2011). Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling. BIOMATERIALS, 32(30), 7524-7531.Elsevier. doi: 10.1016/j.biomaterials.2011.06.050.

Yates, C.C., Bodnar, R., & Wells, A. (2011). Matrix control of scarring. CELLULAR AND MOLECULAR LIFE SCIENCES, 68(11), 1871-1881.Springer Nature. doi: 10.1007/s00018-011-0663-0.

Bae, Y.H., Ding, Z., Das, T., Wells, A., Gertler, F., & Roy, P. (2010). Profilin1 regulates PI(3,4)P₂ and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(50), 21547-21552.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1002309107.

Chao, Y.L., Shepard, C.R., & Wells, A. (2010). Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. MOLECULAR CANCER, 9(1), 179.Springer Nature. doi: 10.1186/1476-4598-9-179.

Hood, B.L., Grahovac, J., Flint, M.S., Sun, M., Charro, N., Becker, D., Wells, A., & Conrads, T.P. (2010). Proteomic Analysis of Laser Microdissected Melanoma Cells from Skin Organ Cultures. JOURNAL OF PROTEOME RESEARCH, 9(7), 3656-3663.American Chemical Society (ACS). doi: 10.1021/pr100164x.

Krishna, P., Regner, M., Palko, J., Liu, F., Abramowitch, S., Jiang, J., & Wells, A. (2010). The Effects of Decorin and HGF-Primed Vocal Fold Fibroblasts In Vitro and Ex Vivo in a Porcine Model of Vocal Fold Scarring. LARYNGOSCOPE, 120(11), 2247-2257.Wiley. doi: 10.1002/lary.21087.

Leloup, L., Shao, H., Bae, Y.H., Deasy, B., Stolz, D., Roy, P., & Wells, A. (2010). m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(43), 33549-33566.Elsevier. doi: 10.1074/jbc.M110.123604.

Li, M., Aliotta, J.M., Asara, J.M., Wu, Q., Dooner, M.S., Tucker, L.D., Wells, A., Quesenberry, P.J., & Ramratnam, B. (2010). Intercellular Transfer of Proteins as Identified by Stable Isotope Labeling of Amino Acids in Cell Culture. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(9), 6285-6297.Elsevier. doi: 10.1074/jbc.M109.057943.

Rodrigues, M., Griffith, L.G., & Wells, A. (2010). Growth factor regulation of proliferation and survival of multipotential stromal cells. STEM CELL RESEARCH & THERAPY, 1(4), 32.Springer Nature. doi: 10.1186/scrt32.

Shao, H., Wang, J.H.C., Pollak, M.R., & Wells, A. (2010). α-Actinin-4 Is Essential for Maintaining the Spreading, Motility and Contractility of Fibroblasts. In Hotchin, N.A. (Ed.). PLOS ONE, 5(11), e13921.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0013921.

Shao, H., Wu, C., & Wells, A. (2010). Phosphorylation of α-Actinin 4 upon Epidermal Growth Factor Exposure Regulates Its Interaction with Actin. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(4), 2591-2600.Elsevier. doi: 10.1074/jbc.M109.035790.

Silver, K., Leloup, L., Freeman, L.C., Wells, A., & Lillich, J.D. (2010). Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 42(12), 2030-2036.Elsevier. doi: 10.1016/j.biocel.2010.09.007.

Simpson, R.M.L., Wells, A., Thomas, D., Stephens, P., Steadman, R., & Phillips, A. (2010). Aging Fibroblasts Resist Phenotypic Maturation Because of Impaired Hyaluronan-Dependent CD44/Epidermal Growth Factor Receptor Signaling. AMERICAN JOURNAL OF PATHOLOGY, 176(3), 1215-1228.Elsevier. doi: 10.2353/ajpath.2010.090802.

Tamama, K., Kawasaki, H., & Wells, A. (2010). Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010(1), 795385.Hindawi. doi: 10.1155/2010/795385.

Wells, A. (2010). Genetics of Neurologic and Psychiatric Diseases Preface. CLINICS IN LABORATORY MEDICINE, 30(4), XIII-XIV.Elsevier. doi: 10.1016/j.cll.2010.07.012.

Wells, A., & Leloup, L. (2010). Calpain. In Handbook of Cell Signaling. 2, (pp. 999-1008).Elsevier. doi: 10.1016/b978-0-12-374145-5.00126-1.

Yates, C.C., Krishna, P., Whaley, D., Bodnar, R., Turner, T., & Wells, A. (2010). Lack of CXC Chemokine Receptor 3 Signaling Leads to Hypertrophic and Hypercellular Scarring. AMERICAN JOURNAL OF PATHOLOGY, 176(4), 1743-1755.Elsevier. doi: 10.2353/ajpath.2010.090564.

Bae, Y.H., Ding, Z., Zou, L., Wells, A., Gertler, F., & Roy, P. (2009). Loss of Profilin-1 Expression Enhances Breast Cancer Cell Motility by Ena/VASP Proteins. JOURNAL OF CELLULAR PHYSIOLOGY, 219(2), 354-364.Wiley. doi: 10.1002/jcp.21677.

Bodnar, R.J., Yates, C.C., Rodgers, M.E., Du, X., & Wells, A. (2009). IP-10 induces dissociation of newly formed blood vessels. JOURNAL OF CELL SCIENCE, 122(12), 2064-2077.The Company of Biologists. doi: 10.1242/jcs.048793.

Das, T., Bae, Y.H., Wells, A., & Roy, P. (2009). Profilin-1 Overexpression Upregulates PTEN and Suppresses AKT Activation in Breast Cancer Cells. JOURNAL OF CELLULAR PHYSIOLOGY, 218(2), 436-443.Wiley. doi: 10.1002/jcp.21618.

Ding, Z., Gaua, D., Deasy, B., Wells, A., & Roy, P. (2009). Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells. EXPERIMENTAL CELL RESEARCH, 315(17), 2963-2973.Elsevier. doi: 10.1016/j.yexcr.2009.07.004.

Marcantonio, N.A., Boehm, C.A., Rozic, R.J., Au, A., Wells, A., Muschler, G.F., & Griffith, L.G. (2009). The influence of tethered epidermal growth factor on connective tissue progenitor colony formation. BIOMATERIALS, 30(27), 4629-4638.Elsevier. doi: 10.1016/j.biomaterials.2009.05.061.

Platt, M.O., Roman, A.J., Wells, A., Lauffenburger, D.A., & Griffith, L.G. (2009). Sustained Epidermal Growth Factor Receptor Levels and Activation by Tethered Ligand Binding Enhances Osteogenic Differentiation of Multi-Potent Marrow Stromal Cells. JOURNAL OF CELLULAR PHYSIOLOGY, 221(2), 306-317.Wiley. doi: 10.1002/jcp.21854.

Platt, M.O., Wilder, C.L., Wells, A., Griffith, L.G., & Lauffenburger, D.A. (2009). Multipathway Kinase Signatures of Multipotent Stromal Cells are Predictive for Osteogenic Differentiation. STEM CELLS, 27(11), 2804-2814.Oxford University Press (OUP). doi: 10.1002/stem.215.

Yates, C.C., Whaley, D., Hooda, S., Hebda, P.A., Bodnar, R.J., & Wells, A. (2009). Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3. WOUND REPAIR AND REGENERATION, 17(1), 34-41.Wiley. doi: 10.1111/j.1524-475X.2008.00439.x.

Iyer, A.K.V., Tran, K.T., Griffith, L., & Wells, A. (2008). Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling. JOURNAL OF CELLULAR PHYSIOLOGY, 214(2), 504-512.Wiley. doi: 10.1002/jcp.21232.

Kim, H.D., Guo, T.W., Wu, A.P., Wells, A., Gertler, F.B., & Lauffenburger, D.A. (2008). Epidermal Growth Factor-induced Enhancement of Glioblastoma Cell Migration in 3D Arises from an Intrinsic Increase in Speed But an Extrinsic Matrix- and Proteolysis-dependent Increase in Persistence. In Schwarzbauer, J.E. (Ed.). MOLECULAR BIOLOGY OF THE CELL, 19(10), 4249-4259.American Society for Cell Biology (ASCB). doi: 10.1091/mbc.E08-05-0501.

Mi, Z., Holmes, F.A., Hellerstedt, B., Pippen, J., Collea, R., Backner, A., Bush, J.E., Gallion, H.H., Wells, A., & O'Shaughnessy, J.A. (2008). Feasibility assessment of a chemoresponse assay to predict pathologic response in neoadjuvant chemotherapy for breast cancer patients. Anticancer Research, 28(3 B), 1733-1740.

Nozawa, H., Howell, G., Suzuki, S., Zhang, Q., Qi, Y., Klein-Seetharaman, J., Wells, A., Grandis, J.R., & Thomas, S.M. (2008). Combined inhibition of PLCγ-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion. CLINICAL CANCER RESEARCH, 14(13), 4336-4344.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-07-4857.

Shao, H., Yi, X.M., & Wells, A. (2008). Epidermal growth factor protects fibroblasts from apoptosis via PI3 kinase and Rac signaling pathways. WOUND REPAIR AND REGENERATION, 16(4), 551-558.Wiley. doi: 10.1111/j.1524-475X.2008.00402.x.

Sharrow, A.C., li, Y., Micsenyi, A., Griswold, R.D., Wells, A., Monga, S.S.P., & Blair, H.C. (2008). Modulation of osteoblast gap junction connectivity by serum, TNFα, and TRAIL. EXPERIMENTAL CELL RESEARCH, 314(2), 297-308.Elsevier. doi: 10.1016/j.yexcr.2007.10.010.

Tamama, K., Sen, C.K., & Wells, A. (2008). Differentiation of Bone Marrow Mesenchymal Stem Cells into the Smooth Muscle Lineage by Blocking ERK/MAPK Signaling Pathway. STEM CELLS AND DEVELOPMENT, 17(5), 897-908.Mary Ann Liebert. doi: 10.1089/scd.2007.0155.

Wells, A., Yates, C., & Shepard, C.R. (2008). E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. CLINICAL & EXPERIMENTAL METASTASIS, 25(6), 621-628.Springer Nature. doi: 10.1007/s10585-008-9167-1.

Yates, C.C., Whaley, D., Y-Chen, A., Kulesekaran, P., Hebda, P.A., & Wells, A. (2008). ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair. AMERICAN JOURNAL OF PATHOLOGY, 173(3), 643-652.Elsevier. doi: 10.2353/ajpath.2008.070990.

Blair, H.C., Wells, A., & Isales, C.M. (2007). Pituitary glycoprotein hormone receptors in non-endocrine organs. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 18(6), 227-233.Elsevier. doi: 10.1016/j.tem.2007.06.001.

Fan, V.H., Au, A., Tamama, K., Littrell, R., Richardson, L.B., Wright, J.W., Wells, A., & Griffith, L.G. (2007). Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells. STEM CELLS, 25(5), 1241-1251.Oxford University Press (OUP). doi: 10.1634/stemcells.2006-0320.

Iyer, A.K.V., Tran, K.T., Borysenko, C.W., Cascio, M., Camacho, C.J., Blair, H.C., Bahar, I., & Wells, A. (2007). Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity. JOURNAL OF CELLULAR PHYSIOLOGY, 211(3), 748-758.Wiley. doi: 10.1002/jcp.20986.

Joslin, E.J., Opresko, L.K., Wells, A., Wiley, H.S., & Lauffenburger, D.A. (2007). EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. JOURNAL OF CELL SCIENCE, 120(20), 3688-3699.The Company of Biologists. doi: 10.1242/jcs.010488.

Kharait, S., Hautaniemi, S., Wu, S., Iwabu, A., Lauffenburger, D.A., & Wells, A. (2007). Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility. BMC SYSTEMS BIOLOGY, 1(1), 9.Springer Nature. doi: 10.1186/1752-0509-1-9.

Shepard, C.R., Kassis, J., Whaley, D.L., Kim, H.G., & Wells, A. (2007). PLCγ contributes to metastasis of in situ-occurring mammary and prostate tumors. ONCOGENE, 26(21), 3020-3026.Springer Nature. doi: 10.1038/sj.onc.1210115.

Wells, A. (2007). Calpain. In xPharm: The Comprehensive Pharmacology Reference. (pp. 1-8).Elsevier. doi: 10.1016/b978-008055232-3.60557-4.

Wells, A., & Smith, B.R. (2007). The goals of resident training in laboratory medicine in combined anatomic pathology/clinical pathology programs: An overview. CLINICS IN LABORATORY MEDICINE, 27(2), 229-+.Elsevier. doi: 10.1016/j.cll.2007.03.001.

Yaroslavskiy, B.B., Sharrow, A.C., Wells, A., Robinson, L.J., & Blair, H.C. (2007). Necessity of inositol (1,4,5)-trisphosphate receptor 1 and μ-calpain in NO-induced osteoclast motility. JOURNAL OF CELL SCIENCE, 120(16), 2884-2894.The Company of Biologists. doi: 10.1242/jcs.004184.

Yates, C., Shepard, C.R., Papworth, G., Dash, A., Stolz, D.B., Tannenbaum, S., Griffith, L., & Wells, A. (2007). Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression. ADVANCES IN CANCER RESEARCH, VOL 97, 97, 225-+.Elsevier. doi: 10.1016/S0065-230X(06)97010-9.

Yates, C.C., Shepard, C.R., Stolz, D.B., & Wells, A. (2007). Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin. BRITISH JOURNAL OF CANCER, 96(8), 1246-1252.Springer Nature. doi: 10.1038/sj.bjc.6603700.

Yates, C.C., Whaley, D., Babu, R., Zhang, J., Krishna, P., Beckman, E., Pasculle, A.W., & Wells, A. (2007). The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models. BIOMATERIALS, 28(27), 3977-3986.Elsevier. doi: 10.1016/j.biomaterials.2007.05.008.

Yates, C.C., Whaley, D., Kulasekeran, P., Hancock, W.W., Lu, B., Bodnar, R., Newsome, J., Hebda, P.A., & Wells, A. (2007). Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor. AMERICAN JOURNAL OF PATHOLOGY, 171(2), 484-495.Elsevier. doi: 10.2353/ajpath.2007.061092.

Zou, L., Jaramillo, M., Whaley, D., Wells, A., Panchapakesa, V., Das, T., & Roy, P. (2007). Profilin-1 is a negative regulator of mammary carcinoma aggressiveness. BRITISH JOURNAL OF CANCER, 97(10), 1361-1371.Springer Nature. doi: 10.1038/sj.bjc.6604038.

Babu, R., Zhang, J., Beckman, E.J., Virji, M., Pasculle, W.A., & Wells, A. (2006). Antimicrobial activities of silver used as a polymerization catalyst for a wound-healing matrix. BIOMATERIALS, 27(24), 4304-4314.Elsevier. doi: 10.1016/j.biomaterials.2006.03.038.

Bodnar, R.J., Yates, C.C., & Wells, A. (2006). IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. CIRCULATION RESEARCH, 98(5), 617-625.Wolters Kluwer. doi: 10.1161/01.RES.0000209968.66606.10.

Gallion, H., Christopherson, W.A., Coleman, R.L., Demars, L., Herzog, T., Hosford, S., Schellhas, H., Wells, A., & Sevin, B.U. (2006). Progression-free interval in ovarian cancer and predictive value of an ex vivo chemoresponse assay. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 16(1), 194-201.BMJ. doi: 10.1111/j.1525-1438.2006.00301.x.

Kharait, S., Dhir, R., Lauffenburger, D., & Wells, A. (2006). Protein kinase Cδ signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells. Biochemical and Biophysical Research Communications, 343(3), 848-856.Elsevier. doi: 10.1016/j.bbrc.2006.03.044.

Krishna, P., Rosen, C.A., Branski, R.C., Wells, A., & Hebda, P.A. (2006). Primed fibroblasts and exogenous decorin: Potential treatments for subacute vocal fold scar. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 135(6), 937-945.Wiley. doi: 10.1016/j.otohns.2006.07.011.

Satish, L., Lyons-Weiler, J., Hebda, P.A., & Wells, A. (2006). Gene expression patterns in isolated keloid fibroblasts. WOUND REPAIR AND REGENERATION, 14(4), 463-470.Wiley. doi: 10.1111/j.1743-6109.2006.00135.x.

Shao, H., Chou, J., Baty, C.J., Burke, N.A., Watkins, S.C., Beer Stolz, D., & Wells, A. (2006). Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation. MOLECULAR AND CELLULAR BIOLOGY, 26(14), 5481-5496.Taylor & Francis. doi: 10.1128/MCB.02243-05.

Smith, B.R., Wells, A., Alexander, C.B., Bovill, E., Campbell, S., Dasgupta, A., Fung, M., Haller, B., Howe, J.G., Parvin, C., Peerschke, E., Rinder, H., Spitalnik, S., Weiss, R., & Wener, M. (2006). Curriculum content and evaluation of resident competency in clinical pathology (Laboratory medicine): A proposal. CLINICAL CHEMISTRY, 52(6), 917-949.Oxford University Press (OUP). doi: 10.1373/clinchem.2005.066076.

Smith, B.R., Wells, A., Alexander, C.B., Bovill, E., Campbell, S., Dasgupta, A., Fung, M., Haller, B., Howe, J.G., Parvin, C., Peerschke, E., Rinder, H., Spitalnik, S., Weiss, R., & Wener, M. (2006). Curriculum content and evaluation of resident competency in clinical pathology (laboratory medicine): a proposal. HUMAN PATHOLOGY, 37(8), 934-968.Elsevier. doi: 10.1016/j.humpath.2006.01.034.

Smith, K.D., Wells, A., & Lauffenburyer, D.A. (2006). Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts. EXPERIMENTAL CELL RESEARCH, 312(11), 1970-1982.Elsevier. doi: 10.1016/j.yexcr.2006.02.022.

Tamama, K., Fan, V.H., Griffith, L.G., Blair, H.C., & Wells, A. (2006). Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. STEM CELLS, 24(3), 686-695.Oxford University Press (OUP). doi: 10.1634/stemcells.2005-0176.

Wells, A., & Smith, B. (2006). Counterpoint developing a clinical pathology curriculum to meet current and future needs. CLINICAL CHEMISTRY, 52(6), 971-972.Oxford University Press (OUP). doi: 10.1373/clinchem.2006.070540.

Wells, A., Harms, B., Iwabu, A., Koo, L., Smith, K., Griffith, L., & Lauffenburger, D.A. (2006). Motility Signaled From the EGF Receptor and Related Systems. Methods in Molecular Biology, 327, 159-177.Springer Nature. doi: 10.1385/1-59745-012-x:159.

Wells, A., Smith, B.R., & Sacks, D.B. (2006). The challenge of training pathologists in the 21st century. HUMAN PATHOLOGY, 37(8), 932-933.Elsevier. doi: 10.1016/j.humpath.2006.01.033.

Yu, G.Y., Tseng, G.C., Yu, Y.P., Gavel, T., Nelson, J., Wells, A., Michalopoulos, G., Kokkinakis, D., & Luo, J.H. (2006). CSR1 suppresses tumor growth and metastasis of prostate cancer. AMERICAN JOURNAL OF PATHOLOGY, 168(2), 597-607.Elsevier. doi: 10.2353/ajpath.2006.050620.

Zaman, M.H., Trapani, L.M., Siemeski, A., MacKellar, D., Gong, H., Kamm, R.D., Wells, A., Lauffenburger, D.A., & Matsudaira, P. (2006). Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(29), 10889-10894.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0604460103.

Zhou, W., Grandis, J.R., & Wells, A. (2006). STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines. BRITISH JOURNAL OF CANCER, 95(2), 164-171.Springer Nature. doi: 10.1038/sj.bjc.6603234.

Hautaniemi, S., Kharait, S., Iwabu, A., Wells, A., & Lauffenburger, D.A. (2005). Modeling of signal-response cascades using decision tree analysis. BIOINFORMATICS, 21(9), 2027-2035.Oxford University Press (OUP). doi: 10.1093/bioinformatics/bti278.

Hendriks, B.S., Orr, G., Wells, A., Wiley, H.S., & Lauffenburger, D.A. (2005). Parsing ERK Activation Reveals Quantitatively Equivalent Contributions from Epidermal Growth Factor Receptor and HER2 in Human Mammary Epithelial Cells*. Journal of Biological Chemistry, 280(7), 6157-6169.Elsevier. doi: 10.1074/jbc.m410491200.

Lai, S.Y., Childs, E.E., Xi, S., Coppelli, F.M., Gooding, W.E., Wells, A., Ferris, R.L., & Grandis, J.R. (2005). Erratum: Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma. Oncogene, 24(55), 8216.Springer Nature. doi: 10.1038/sj.onc.1209224.

Lai, S.Y., Childs, E.E., Xi, S.C., Coppelli, F.M., Gooding, W.E., Wells, A., Ferris, R.L., & Grandis, J.R. (2005). Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma. ONCOGENE, 24(27), 4442-4449.Springer Nature. doi: 10.1038/sj.onc.1208635.

Satish, L., Blair, H.C., Glading, A., & Wells, A. (2005). Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of μ-calpain. MOLECULAR AND CELLULAR BIOLOGY, 25(5), 1922-1941.Taylor & Francis. doi: 10.1128/MCB.25.5.1922-1941.2005.

Wang, J., Zhang, X., Thomas, S.M., Grandis, J.R., Wells, A., Chen, Z., & Ferris, R.L. (2005). Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR. ONCOGENE, 24(38), 5897-5904.Springer Nature. doi: 10.1038/sj.onc.1208740.

Wells, A. (2005). EGFR in metastasis. Signal, 6(2), 17-19.

Wells, A., Huttenlocher, A., & Lauffenburger, D.A. (2005). Calpain proteases in cell adhesion and motility. INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 245, 245, 1-16.Elsevier. doi: 10.1016/S0074-7696(05)45001-9.

Yates, C., Wells, A., & Turner, T. (2005). Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline. BRITISH JOURNAL OF CANCER, 92(2), 366-375.Springer Nature. doi: 10.1038/sj.bjc.6602350.

Glading, A., Bodnar, R.J., Reynolds, I.J., Shiraha, H., Satish, L., Potter, D.A., Blair, H.C., & Wells, A. (2004). Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation (vol 24, pg 2499, 2004). MOLECULAR AND CELLULAR BIOLOGY, 24(13), 6116.Taylor & Francis. doi: 10.1128/MCB.24.13.6116.2004.

Glading, A., Bodnar, R.J., Reynolds, I.J., Shiraha, H., Satish, L., Potter, D.A., Blair, H.C., & Wells, A. (2004). Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation. MOLECULAR AND CELLULAR BIOLOGY, 24(6), 2499-2512.Taylor & Francis. doi: 10.1128/MCB.24.6.2499-2512.2004.

Iwabu, A., Smith, K., Allen, F.D., Lauffenburger, D.A., & Wells, A. (2004). Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C δ-dependent pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(15), 14551-14560.Elsevier. doi: 10.1074/jbc.M311981200.

Jing, L., Liu, L.J., Yu, Y.P., Dhir, R., Acquafondada, M., Landsittel, D., Cieply, K., Wells, A., & Luo, J.H. (2004). Expression of myopodin induces suppression of tumor growth and metastasis. AMERICAN JOURNAL OF PATHOLOGY, 164(5), 1799-1806.Elsevier. doi: 10.1016/S0002-9440(10)63738-8.

Kornblith, P., Ochs, R.L., Wells, A., Gabrin, M.J., Piwowar, J., Chattopadhyay, A., George, L.D., & Burholt, D. (2004). Differential in vitro effects of chemotherapeutic agents on primary cultures of human ovarian carcinoma. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 14(4), 607-615.BMJ. doi: 10.1111/j.1048-891X.2004.14408.x.

Larsen, A.K., De Veyra, T., Jia, Z.C., Wells, A., Dutt, P., & Elce, J.S. (2004). Expression of human, mouse, and rat m-calpains in Escherichia coli and in murine fibroblasts. PROTEIN EXPRESSION AND PURIFICATION, 33(2), 246-255.Elsevier. doi: 10.1016/j.pep.2003.10.005.

Mamoune, A., Kassis, J., Kharait, S., Kloeker, S., Manos, E., Jones, D.A., & Wells, A. (2004). DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling. EXPERIMENTAL CELL RESEARCH, 299(1), 91-100.Elsevier. doi: 10.1016/j.yexcr.2004.05.008.

Priya, K.S., Arumugam, G., Rathinam, B., Wells, A., & Babu, M. (2004). Celosia argentea Linn. leaf extract improves wound healing in a rat burn wound model. WOUND REPAIR AND REGENERATION, 12(6), 618-625.Wiley. doi: 10.1111/j.1067-1927.2004.12603.x.

Satish, L., Babu, M., Tran, K.T., Hebda, P.A., & Wells, A. (2004). Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways. WOUND REPAIR AND REGENERATION, 12(2), 183-192.Wiley. doi: 10.1111/j.1067-1927.2004.012111.x.

Tran, K.T., Griffith, L., & Wells, A. (2004). Extracellular matrix signaling through growth factor receptors during wound healing. WOUND REPAIR AND REGENERATION, 12(3), 262-268.Wiley. doi: 10.1111/j.1067-1927.2004.012302.x.

Wells, A., & Lillien, L. (2004). Attraction or Repulsion: A Matter of Individual Taste?. Science Signaling, 2004(253), pe47.American Association for the Advancement of Science (AAAS). doi: 10.1126/stke.2532004pe47.

Yagi, Y., Ahmed, I., Gross, W., Becich, M.J., Demetris, A.J., Wells, A., Wiley, C.A., Michalopoulos, G.K., Yousem, S.A., Barnes, B., & Gilbertson, J.R. (2004). Webcasting pathology department conferences in a geographically distributed medical center. HUMAN PATHOLOGY, 35(7), 790-797.Elsevier. doi: 10.1016/j.humpath.2004.03.013.

Chou, J., Burke, N.A., Iwabu, A., Watkins, S.C., & Wells, A. (2003). Directional motility induced by epidermal growth factor requires Cdc42. EXPERIMENTAL CELL RESEARCH, 287(1), 47-56.Elsevier. doi: 10.1016/S0014-4827(03)00119-8.

Hebda, P.A., Whaley, D., Kim, H.G., & Wells, A. (2003). Absence of inhibition of cutaneous wound healing in mice by oral doxycycline. WOUND REPAIR AND REGENERATION, 11(5), 373-379.Wiley. doi: 10.1046/j.1524-475X.2003.11510.x.

Kornblith, P., Wells, A., Gabrin, M.J., Piwowar, J., Chattopadhyay, A., George, L.D., Ochs, R.L., & Burholt, D. (2003). In vitro responses of ovarian cancers to platinums and taxanes. Anticancer Research, 23(1 B), 543-548.

Kornblith, P., Wells, A., Gabrin, M.J., Piwowar, J., George, L.D., Ochs, R.L., & Burholt, D. (2003). Breast cancer -: Response rates to chemotherapeutic agents studied in vitro. ANTICANCER RESEARCH, 23(4), 3405-3411.

Lauffenburger, D.A., & Wells, A. (2003). Quantitative parsing of cell multi-tasking in wound repair and tissue morphogenesis. BIOPHYSICAL JOURNAL, 84(6), 3499-3500.Elsevier. doi: 10.1016/S0006-3495(03)75084-X.

Mamoune, A., Luo, J.H., Lauffenburger, D.A., & Wells, A. (2003). Calpain-2 as a target for limiting prostate cancer invasion. CANCER RESEARCH, 63(15), 4632-4640.

Ochs, R.L., Fensterer, J., Ohori, N.P., Wells, A., Gabrin, M., George, L.D., & Kornblith, P. (2003). Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 39(1-2), 63-70. doi: 10.1290/1543-706X(2003)039<0063:EFTIGA>2.0.CO;2.

OCHS, R.L., FENSTERER, J., OHORI, N.P., WELLS, A., GABRIN, M., GEORGE, L.D., & KORNBLITH, P. (2003). EVIDENCE FOR THE ISOLATION, GROWTH, AND CHARACTERIZATION OF MALIGNANT CELLS IN PRIMARY CULTURES OF HUMAN TUMORS. In Vitro Cellular & Developmental Biology - Animal, 39(1), 63-70.Springer Nature. doi: 10.1290/1543-706x(2003)039<0063:eftiga>2.0.co;2.

Satish, L., Yager, D., & Wells, A. (2003). Glu-Leu-Arg-negative CXC chemokine interferon γ inducible protein-9 as a mediator of epidermal-dermal communication during wound repair. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 120(6), 1110-1117.Elsevier. doi: 10.1046/j.1523-1747.2003.12230.x.

Smith, S.D., Jia, Z.C., Huynh, K.K., Wells, A., & Elce, J.S. (2003). Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation. FEBS LETTERS, 542(1-3), 115-118.Wiley. doi: 10.1016/S0014-5793(03)00361-2.

Thomas, S.M., Coppelli, F.M., Wells, A., Gooding, W.E., Song, J., Kassis, J., Drenning, S.D., & Grandis, J.R. (2003). Epidermal growth factor receptor-stimulated activation of phospholipase Cγ-1 promotes invasion of head and neck squamous cell carcinoma. CANCER RESEARCH, 63(17), 5629-5635.

Tran, K.T., Rusu, S.D., Satish, L., & Wells, A. (2003). Aging-related attenuation of EGF receptor signaling is mediated in part by increased protein tyrosine phosphatase activity. EXPERIMENTAL CELL RESEARCH, 289(2), 359-367.Elsevier. doi: 10.1016/S0014-4827(03)00287-8.

Wells, A., & Grandis, J.R. (2003). Phospholipase C-γ1 in tumor progression. CLINICAL & EXPERIMENTAL METASTASIS, 20(4), 285-290.Springer Nature. doi: 10.1023/A:1024088922957.

Wells, A., & Huttenlocher, A. (2003). Calpain. In Handbook of Cell Signaling. 2-3, (pp. 105-111).Elsevier. doi: 10.1016/b978-012124546-7/50502-7.

Allen, F.D., Asnes, C.F., Chang, P., Elson, E.L., Lauffenburger, D.A., & Wells, A. (2002). Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation. WOUND REPAIR AND REGENERATION, 10(1), 67-76.Wiley. doi: 10.1046/j.1524-475X.2002.10701.x.

Chou, J., Stolz, D.B., Burke, N.A., Watkins, S.C., & Wells, A. (2002). Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motility. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 34(7), 776-790.Elsevier. doi: 10.1016/S1357-2725(01)00177-7.

Glading, A., Lauffenburger, D.A., & Wells, A. (2002). Cutting to the chase: calpain proteases in cell motility. TRENDS IN CELL BIOLOGY, 12(1), 46-54.Elsevier. doi: 10.1016/S0962-8924(01)02179-1.

Kassis, J., Maeda, A., Teramoto, N., Takada, K., Wu, C.Y., Klein, G., & Wells, A. (2002). EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness. INTERNATIONAL JOURNAL OF CANCER, 99(5), 644-651.Wiley. doi: 10.1002/ijc.10382.

Kassis, J., Radinsky, R., & Wells, A. (2002). Motility is rate-limiting for invasion of bladder carcinoma cell lines. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 34(7), 762-775.Elsevier. doi: 10.1016/S1357-2725(01)00173-X.

Shiraha, H., Glading, A., Chou, J., Jia, Z.C., & Wells, A. (2002). Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase a phosphorylation of m-calpain. MOLECULAR AND CELLULAR BIOLOGY, 22(8), 2716-2727.Taylor & Francis. doi: 10.1128/MCB.22.8.2716-2727.2002.

Wells, A., & Marti, U. (2002). Signaling shortcuts: cell-surface receptors in the nucleus?. Nature Reviews Molecular Cell Biology, 3(9), 697-6U1.Nature Research (part of Springer Nature). doi: 10.1038/nrm905.

Wells, A., Kassis, J., Solava, J., Turner, T., & Lauffenburger, D.A. (2002). Growth factor-induced cell motility in tumor invasion. ACTA ONCOLOGICA, 41(2), 124-130.MJS Publishing, Medical Journals Sweden AB. doi: 10.1080/028418602753669481.

Wells, A., Kharait, S., Yates, C., & Satish, L. (2002). 19 Calpain proteases in prostate carcinoma. Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas, 2, 463-469.Elsevier. doi: 10.1016/s1874-5784(02)80051-4.

Wells, A., Souto, J.C.S., Solava, J., Kassis, J., Bailey, K.J., & Turner, T. (2002). Luteinizing hormone-releasing hormone agonist limits DU-145 prostate cancer growth by attenuating epidermal growth factor receptor signaling. CLINICAL CANCER RESEARCH, 8(4), 1251-1257.

Babu, M., & Wells, A. (2001). Dermal-epidermal communication in wound healing. WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE, 13(5), 183-189.

Barbieri, M.A., Heath, C.M., Peters, E.M., Wells, A., Davis, J.N., & Stahl, P.D. (2001). Phosphatidylinositol-4-phosphate 5-kinase-1β is essential for epidermal growth factor receptor-mediated endocytosis. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(50), 47212-47216.Elsevier. doi: 10.1074/jbc.C100490200.

Deb, T.B., Su, L., Wong, L., Bonvini, E., Wells, A., David, M., & Johnson, G.R. (2001). Epidermal growth factor (EGF) receptor kinase-independent signaling by EGF. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(18), 15554-15560.Elsevier. doi: 10.1074/jbc.M100928200.

Glading, A., Überall, F., Keyse, S.M., Lauffenburger, D.A., & Wells, A. (2001). Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(26), 23341-23348.Elsevier. doi: 10.1074/jbc.M008847200.

Kassis, J., Lauffenburger, D.A., Turner, T., & Wells, A. (2001). Tumor invasion as dysregulated cell motility. SEMINARS IN CANCER BIOLOGY, 11(2), 105-117.Elsevier. doi: 10.1006/scbi.2000.0362.

Lauffenburger, D.A., & Wells, A. (2001). Getting a grip: new insights for cell adhesion and traction. NATURE CELL BIOLOGY, 3(5), E110-E112.Springer Nature. doi: 10.1038/35074631.

Manos, E.J., Kim, M.L.H., Kassis, J., Chang, P.Y., Wells, A., & Jones, D.A. (2001). Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-γ regulated gene negatively associated with prostate tumor invasion. ONCOGENE, 20(22), 2781-2790.Springer Nature. doi: 10.1038/sj.onc.1204379.

Swindle, C.S., Tran, K.T., Johnson, T.D., Banerjee, P., Mayes, A.M., Griffith, L., & Wells, A. (2001). Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. JOURNAL OF CELL BIOLOGY, 154(2), 459-468.Rockefeller University Press. doi: 10.1083/jcb.200103103.

Barbieri, M.A., Roberts, R.L., Gumusboga, A., Highfield, H., Alvarez-Dominguez, C., Wells, A., & Stahl, P.D. (2000). Epidermal growth factor and membrane trafficking: EGF receptor activation of endocytosis requires Rab5a. JOURNAL OF CELL BIOLOGY, 151(3), 539-550.Rockefeller University Press. doi: 10.1083/jcb.151.3.539.

Botelho, R.J., Teruel, M., Dierckman, R., Anderson, R., Wells, A., York, J.D., Meyer, T., & Grinstein, S. (2000). Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. JOURNAL OF CELL BIOLOGY, 151(7), 1353-1367.Rockefeller University Press. doi: 10.1083/jcb.151.7.1353.

Glading, A., Chang, P., Lauffenburger, D.A., & Wells, A. (2000). Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(4), 2390-2398.Elsevier. doi: 10.1074/jbc.275.4.2390.

Haugh, J.M., Wells, A., & Lauffenburger, D.A. (2000). Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions. Biotechnology and Bioengineering, 70(2), 225-238.Wiley. doi: 10.1002/1097-0290(20001020)70:2<225::aid-bit12>3.0.co;2-s.

Maheshwari, G., Brown, G., Lauffenburger, D.A., Wells, A., & Griffith, L.G. (2000). Cell adhesion and motility depend on nanoscale RGD clustering. JOURNAL OF CELL SCIENCE, 113(10), 1677-1686.The Company of Biologists. doi: 10.1242/jcs.113.10.1677.

Marti, U., & Wells, A. (2000). The Nuclear Accumulation of a Variant Epidermal Growth Factor Receptor (EGFR) Lacking the Transmembrane Domain Requires Coexpression of a Full-Length EGFR. Archives of Biochemistry and Biophysics, 3(1), 8-14.Elsevier. doi: 10.1006/mcbr.2000.0177.

Shiraha, H., Gupta, K., Drabik, K., & Wells, A. (2000). Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(25), 19343-19351.Elsevier. doi: 10.1074/jbc.M000008200.

Haugh, J.M., Huang, A.C., Wiley, H.S., Wells, A., & Lauffenburger, D.A. (1999). Internalized epidermal growth factor receptors participate in the activation of p21^ras in fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(48), 34350-34360.Elsevier. doi: 10.1074/jbc.274.48.34350.

Haugh, J.M., Schooler, K., Wells, A., Wiley, H.S., & Lauffenburger, D.A. (1999). Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-γ1 signaling pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(13), 8958-8965.Elsevier. doi: 10.1074/jbc.274.13.8958.

Kassis, J., Moellinger, J., Lo, H., Greenberg, N.M., Kim, H.G., & Wells, A. (1999). A role for phospholipase C-γ-mediated signaling in tumor cell invasion. CLINICAL CANCER RESEARCH, 5(8), 2251-2260.

Shiraha, H., Glading, A., Gupta, K., & Wells, A. (1999). IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity. JOURNAL OF CELL BIOLOGY, 146(1), 243-253.Rockefeller University Press. doi: 10.1083/jcb.146.1.243.

Wells, A. (1999). Tumor Invasion: Role of Growth Factor-Induced Cell Motility. Advances in Cancer Research, 78, 31-101.Elsevier. doi: 10.1016/s0065-230x(08)61023-4.

Wells, A. (1999). EGF receptor. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 31(6), 637-643.Elsevier. doi: 10.1016/S1357-2725(99)00015-1.

Wells, A., Ware, M.F., Allen, F.D., & Lauffenburger, D.A. (1999). Shaping up for shipping out: PLCγ signaling of morphology changes in EGF-stimulated fibroblast migration. Cell Motility and the Cytoskeleton, 44(4), 227-233. doi: 10.1002/(SICI)1097-0169(199912)44:4<227::AID-CM1>3.0.CO;2-B.

Wells, A., Ware, M.F., Allen, F.D., & Lauffenburger, D.A. (1999). Shaping up for shipping out:: PLCγ signaling of morphology changes in EGF-stimulated fibroblast migration. CELL MOTILITY AND THE CYTOSKELETON, 44(4), 227-233.Wiley. doi: 10.1002/(SICI)1097-0169(199912)44:4<227::AID-CM1>3.0.CO;2-B.

Wong, L., Deb, T.B., Thompson, S.A., Wells, A., & Johnson, G.R. (1999). A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(13), 8900-8909.Elsevier. doi: 10.1074/jbc.274.13.8900.

Reddy, C.C., Wells, A., & Lauffenburger, D.A. (1998). Comparative mitogenic potencies of EGF and TGFα and their dependence on receptor-limitation versus ligand-limitation. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 36(4), 499-507.Springer Nature. doi: 10.1007/BF02523222.

Wells, A., Gupta, K., Chang, P., Swindle, S., Glading, A., & Shiraha, H. (1998). Epidermal growth factor receptor-mediated motility in fibroblasts. MICROSCOPY RESEARCH AND TECHNIQUE, 43(5), 395-411.Wiley. doi: 10.1002/(SICI)1097-0029(19981201)43:5<395::AID-JEMT6>3.0.CO;2-T.

Van Epps-Fung, M., Williford, J., Wells, A., & Hardy, R.W. (1997). Fatty Acid-Induced Insulin Resistance in Adipocytes. Endocrinology, 138(10), 4338-4345.The Endocrine Society. doi: 10.1210/endo.138.10.5458.

Zhang, M., Wang, M.H., Singh, R.K., Wells, A., & Siegal, G.P. (1997). Epidermal growth factor induces CD44 gene expression through a novel regulatory element in mouse fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY, 272(22), 14139-14146.Elsevier. doi: 10.1074/jbc.272.22.14139.

Lowenthal, E.A., Wells, A., Emanuel, P.D., Player, R., & Prchal, J.T. (1996). Sickle cell acute chest syndrome associated with parvovirus B19 infection: Case series and review. AMERICAN JOURNAL OF HEMATOLOGY, 51(3), 207-213.Wiley. doi: 10.1002/(SICI)1096-8652(199603)51:3<207::AID-AJH5>3.3.CO;2-B.

Reddy, C.C., Niyogi, S.K., Wells, A., Wiley, H.S., & Lauffenburger, D.A. (1996). Engineering epidermal growth factor for enhanced mitogenic potency. NATURE BIOTECHNOLOGY, 14(13), 1696-1699.Springer Nature. doi: 10.1038/nbt1296-1696.

Reddy, C.C., Wells, A., & Lauffenburger, D.A. (1996). Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. JOURNAL OF CELLULAR PHYSIOLOGY, 166(3), 512-522.Wiley. doi: 10.1002/(SICI)1097-4652(199603)166:3<512::AID-JCP6>3.0.CO;2-S.

Turner, T., Chen, P., Goodly, L.J., & Wells, A. (1996). EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells. CLINICAL & EXPERIMENTAL METASTASIS, 14(4), 409-418.Springer Nature. doi: 10.1007/BF00123400.

XIE, H., TURNER, T., WANG, M.H., SINGH, R.K., SIEGAL, G.P., & WELLS, A. (1995). IN-VITRO INVASIVENESS OF DU-145 HUMAN PROSTATE CARCINOMA-CELLS IS MODULATED BY EGF RECEPTOR-MEDIATED SIGNALS. CLINICAL & EXPERIMENTAL METASTASIS, 13(6), 407-419.Springer Nature. doi: 10.1007/BF00118180.

CHEN, P., XIE, H., SEKAR, M.C., GUPTA, K., & WELLS, A. (1994). EPIDERMAL GROWTH-FACTOR RECEPTOR-MEDIATED CELL MOTILITY - PHOSPHOLIPASE-C ACTIVITY IS REQUIRED, BUT MITOGEN-ACTIVATED PROTEIN-KINASE ACTIVITY IS NOT SUFFICIENT FOR INDUCED CELL-MOVEMENT. JOURNAL OF CELL BIOLOGY, 127(3), 847-857.Rockefeller University Press. doi: 10.1083/jcb.127.3.847.

REDDY, C.C., WELLS, A., & LAUFFENBURGER, D.A. (1994). PROLIFERATIVE RESPONSE OF FIBROBLASTS EXPRESSING INTERNALIZATION-DEFICIENT EPIDERMAL GROWTH-FACTOR (EGF) RECEPTORS IS ALTERED VIA DIFFERENTIAL EGF DEPLETION EFFECT. BIOTECHNOLOGY PROGRESS, 10(4), 377-384.Wiley. doi: 10.1021/bp00028a006.

MARTI, U., BURWEN, S.J., WELLS, A., BARKER, M.E., HULING, S., FEREN, A.M., & JONES, A.L. (1991). LOCALIZATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN HEPATOCYTE NUCLEI. HEPATOLOGY, 13(1), 15-20.Wolters Kluwer. doi: 10.1016/0270-9139(91)90210-M.

JONSSON, V., WELLS, A., & KLEIN, G. (1982). RECEPTORS FOR THE COMPLEMENT C3D COMPONENT AND THE EPSTEIN-BARR VIRUS ARE QUANTITATIVELY COEXPRESSED ON A SERIES OF B-CELL LINES AND THEIR DERIVED SOMATIC-CELL HYBRIDS. CELLULAR IMMUNOLOGY, 72(2), 263-276.Elsevier. doi: 10.1016/0008-8749(82)90474-9.

WELLS, A., GODAL, T., KVALOY, S., STEEN, H.B., & KLEIN, G. (1982). QUANTITATIVE COMPARISON OF EPSTEIN-BARR VIRUS RECEPTOR EXPRESSION ON SIGM AND SIGG CELL-LINES AND B-CELL LYMPHOMA BIOPSIES. DIFFERENTIATION, 22(2), 113-119.Elsevier. doi: 10.1111/j.1432-0436.1982.tb01234.x.

KOIDE, N., WELLS, A., KLEIN, G., & ERNBERG, I. (1981). CELL-SURFACE GLYCOPROTEIN PATTERNS OF 2 EBV-NEGATIVE LINES AND THEIR EBV-CONVERTED SUBLINES. INTERVIROLOGY, 16(3), 142-148.Karger Publishers. doi: 10.1159/000149261.

WELLS, A., KOIDE, N., & KLEIN, G. (1981). DIFFERENCE IN VIRAL BINDING BETWEEN 2 EPSTEIN-BARR VIRUS SUBSTRAINS TO A SPECTRUM OF RECEPTOR-POSITIVE TARGET-CELLS. INTERNATIONAL JOURNAL OF CANCER, 27(3), 303-309.Wiley. doi: 10.1002/ijc.2910270308.

WELLS, A., STEEN, H.B., GODAL, T., & KLEIN, G. (1981). EPSTEIN-BARR VIRUS RECEPTOR EXPRESSION IS CORRELATED TO CELL-CYCLE PHASE. JOURNAL OF RECEPTOR RESEARCH, 2(3), 285-298.Taylor & Francis. doi: 10.3109/10799898109038805.