Yu Chih Chen

Augimeri, G., Gonzalez, M.E., Paolì, A., Eido, A., Choi, Y., Burman, B., Djomehri, S., Karthikeyan, S.K., Varambally, S., Buschhaus, J.M., Chen, Y.C., Mauro, L., Bonofiglio, D., Nesvizhskii, A.I., Luker, G.D., Andò, S., Yoon, E., & Kleer, C.G. (2023). A hybrid breast cancer/mesenchymal stem cell population enhances chemoresistance and metastasis. JCI Insight, 8(18), e164216.American Society for Clinical Investigation. doi: 10.1172/jci.insight.164216.

Sarma, P., Carino, C.M.C., Seetharama, D., Pandey, S., Dwivedi-Agnihotri, H., Rui, X., Cao, Y., Kawakami, K., Kumari, P., Chen, Y.C., Luker, K.E., Yadav, P.N., Luker, G.D., Laporte, S.A., Chen, X., Inoue, A., & Shukla, A.K. (2023). Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system. Nat Commun, 14(1), 4808.Springer Nature. doi: 10.1038/s41467-023-40482-9.

Zhou, M., Ma, Y., Chiang, C.C., Rock, E.C., Luker, K.E., Luker, G.D., & Chen, Y.C. (2023). High-Throughput Cellular Heterogeneity Analysis in Cell Migration at the Single-Cell Level. Small, 19(6), e2206754.Wiley. doi: 10.1002/smll.202206754.

Gonzalez, M.E., Naimo, G.D., Anwar, T., Paolì, A., Tekula, S.R., Kim, S., Medhora, N., Leflein, S.A., Itkin, J., Trievel, R., Kidwell, K.M., Chen, Y.C., Mauro, L., Yoon, E., Andò, S., & Kleer, C.G. (2022). EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression. iScience, 25(8), 104827.Elsevier. doi: 10.1016/j.isci.2022.104827.

Hartnett, E.B., Zhou, M., Gong, Y.N., & Chen, Y.C. (2022). LANCE: a Label-Free Live Apoptotic and Necrotic Cell Explorer Using Convolutional Neural Network Image Analysis. Anal Chem, 94(43), 14827-14834.American Chemical Society (ACS). doi: 10.1021/acs.analchem.2c00878.

Chen, Y.C., Zhang, Z., & Yoon, E. (2020). Early Prediction of Single-Cell Derived Sphere Formation Rate Using Convolutional Neural Network Image Analysis. Anal Chem, 92(11), 7717-7724.American Chemical Society (ACS). doi: 10.1021/acs.analchem.0c00710.

Humphries, B.A., Cutter, A.C., Buschhaus, J.M., Chen, Y.C., Qyli, T., Palagama, D.S.W., Eckley, S., Robison, T.H., Bevoor, A., Chiang, B., Haley, H.R., Sahoo, S., Spinosa, P.C., Neale, D.B., Boppisetti, J., Sahoo, D., Ghosh, P., Lahann, J., Ross, B.D., Yoon, E., Luker, K.E., & Luker, G.D. (2020). Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer. Breast Cancer Res, 22(1), 60.Springer Nature. doi: 10.1186/s13058-020-01301-x.

Park, S.R., Namkoong, S., Friesen, L., Cho, C.S., Zhang, Z.Z., Chen, Y.C., Yoon, E., Kim, C.H., Kwak, H., Kang, H.M., & Lee, J.H. (2020). Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage. Cell Rep, 32(8), 108077.Elsevier. doi: 10.1016/j.celrep.2020.108077.

Chen, Y.C., Gonzalez, M.E., Burman, B., Zhao, X., Anwar, T., Tran, M., Medhora, N., Hiziroglu, A.B., Lee, W., Cheng, Y.H., Choi, Y., Yoon, E., & Kleer, C.G. (2019). Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer. Cell Rep, 27(13), 3916-3926.e5.Elsevier. doi: 10.1016/j.celrep.2019.05.084.

Chen, Y.C., Jung, S., Zhang, Z., Wicha, M.S., & Yoon, E. (2019). Co-culture of functionally enriched cancer stem-like cells and cancer-associated fibroblasts for single-cell whole transcriptome analysis. Integr Biol (Camb), 11(9), 353-361.Oxford University Press (OUP). doi: 10.1093/intbio/zyz029.

Cheng, Y.H., Chen, Y.C., Lin, E., Brien, R., Jung, S., Chen, Y.T., Lee, W., Hao, Z., Sahoo, S., Min Kang, H., Cong, J., Burness, M., Nagrath, S., S Wicha, M., & Yoon, E. (2019). Hydro-Seq enables contamination-free high-throughput single-cell RNA-sequencing for circulating tumor cells. Nat Commun, 10(1), 2163.Springer Nature. doi: 10.1038/s41467-019-10122-2.

Humphries, B.A., Buschhaus, J.M., Chen, Y.C., Haley, H.R., Qyli, T., Chiang, B., Shen, N., Rajendran, S., Cutter, A., Cheng, Y.H., Chen, Y.T., Cong, J., Spinosa, P.C., Yoon, E., Luker, K.E., & Luker, G.D. (2019). Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer. Mol Cancer Res, 17(5), 1142-1154.American Association for Cancer Research (AACR). doi: 10.1158/1541-7786.MCR-18-0836.

Zhang, Z., Chen, L., Wang, Y., Zhang, T., Chen, Y.C., & Yoon, E. (2019). Label-Free Estimation of Therapeutic Efficacy on 3D Cancer Spheres Using Convolutional Neural Network Image Analysis. Anal Chem, 91(21), 14093-14100.American Chemical Society (ACS). doi: 10.1021/acs.analchem.9b03896.

Anwar, T., Arellano-Garcia, C., Ropa, J., Chen, Y.C., Kim, H.S., Yoon, E., Grigsby, S., Basrur, V., Nesvizhskii, A.I., Muntean, A., Gonzalez, M.E., Kidwell, K.M., Nikolovska-Coleska, Z., & Kleer, C.G. (2018). p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis. Nat Commun, 9(1), 2801.Springer Nature. doi: 10.1038/s41467-018-05078-8.

Chen, Y.C., Humphries, B., Brien, R., Gibbons, A.E., Chen, Y.T., Qyli, T., Haley, H.R., Pirone, M.E., Chiang, B., Xiao, A., Cheng, Y.H., Luan, Y., Zhang, Z., Cong, J., Luker, K.E., Luker, G.D., & Yoon, E. (2018). Functional Isolation of Tumor-Initiating Cells using Microfluidic-Based Migration Identifies Phosphatidylserine Decarboxylase as a Key Regulator. Sci Rep, 8(1), 244.Springer Nature. doi: 10.1038/s41598-017-18610-5.

Menon, R., Otto, E.A., Kokoruda, A., Zhou, J., Zhang, Z., Yoon, E., Chen, Y.C., Troyanskaya, O., Spence, J.R., Kretzler, M., & Cebrián, C. (2018). Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney. Development, 145(16), dev164038.The Company of Biologists. doi: 10.1242/dev.164038.

Zhang, Z., Chen, L., Humphries, B., Brien, R., Wicha, M.S., Luker, K.E., Luker, G.D., Chen, Y.C., & Yoon, E. (2018). Morphology-based prediction of cancer cell migration using an artificial neural network and a random decision forest. Integr Biol (Camb), 10(12), 758-767.Oxford University Press (OUP). doi: 10.1039/c8ib00106e.

Zhang, Z., Chen, Y.C., Urs, S., Chen, L., Simeone, D.M., & Yoon, E. (2018). Scalable Multiplexed Drug-Combination Screening Platforms Using 3D Microtumor Model for Precision Medicine. Small, 14(42), e1703617.Wiley. doi: 10.1002/smll.201703617.

Chen, Y.C., Baac, H.W., Lee, K.T., Fouladdel, S., Teichert, K., Ok, J.G., Cheng, Y.H., Ingram, P.N., Hart, A.J., Azizi, E., Guo, L.J., Wicha, M.S., & Yoon, E. (2017). Selective Photomechanical Detachment and Retrieval of Divided Sister Cells from Enclosed Microfluidics for Downstream Analyses. ACS Nano, 11(5), 4660-4668.American Chemical Society (ACS). doi: 10.1021/acsnano.7b00413.

Gonzalez, M.E., Martin, E.E., Anwar, T., Arellano-Garcia, C., Medhora, N., Lama, A., Chen, Y.C., Tanager, K.S., Yoon, E., Kidwell, K.M., Ge, C., Franceschi, R.T., & Kleer, C.G. (2017). Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. Cell Rep, 18(5), 1215-1228.Elsevier. doi: 10.1016/j.celrep.2016.12.079.

Kim, H.S., Chen, Y.C., Nör, F., Warner, K.A., Andrews, A., Wagner, V.P., Zhang, Z., Zhang, Z., Martins, M.D., Pearson, A.T., Yoon, E., & Nör, J.E. (2017). Endothelial-derived interleukin-6 induces cancer stem cell motility by generating a chemotactic gradient towards blood vessels. Oncotarget, 8(59), 100339-100352.Impact Journals. doi: 10.18632/oncotarget.22225.

Allen, S.G., Chen, Y.C., Madden, J.M., Fournier, C.L., Altemus, M.A., Hiziroglu, A.B., Cheng, Y.H., Wu, Z.F., Bao, L., Yates, J.A., Yoon, E., & Merajver, S.D. (2016). Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling. Sci Rep, 6(1), 39190.Springer Nature. doi: 10.1038/srep39190.

Bai, S., Ingram, P., Chen, Y.C., Deng, N., Pearson, A., Niknafs, Y.S., O'Hayer, P., Wang, Y., Zhang, Z.Y., Boscolo, E., Bischoff, J., Yoon, E., & Buckanovich, R.J. (2016). EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells. Cancer Res, 76(21), 6396-6409.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-16-0225.

Chen, Y.C., Cheng, Y.H., Ingram, P., & Yoon, E. (2016). Single Cell Proteolytic Assays to Investigate Cancer Clonal Heterogeneity and Cell Dynamics Using an Efficient Cell Loading Scheme. Sci Rep, 6(1), 27154.Springer Nature. doi: 10.1038/srep27154.

Chen, Y.C., Ingram, P.N., Fouladdel, S., McDermott, S.P., Azizi, E., Wicha, M.S., & Yoon, E. (2016). High-Throughput Single-Cell Derived Sphere Formation for Cancer Stem-Like Cell Identification and Analysis. Sci Rep, 6(1), 27301.Springer Nature. doi: 10.1038/srep27301.

Chen, Y.C., Zhang, Z., Fouladdel, S., Deol, Y., Ingram, P.N., McDermott, S.P., Azizi, E., Wicha, M.S., & Yoon, E. (2016). Single cell dual adherent-suspension co-culture micro-environment for studying tumor-stromal interactions with functionally selected cancer stem-like cells. Lab Chip, 16(15), 2935-2945.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc00062b.

Cheng, Y.H., Chen, Y.C., Brien, R., & Yoon, E. (2016). Scaling and automation of a high-throughput single-cell-derived tumor sphere assay chip. Lab Chip, 16(19), 3708-3717.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc00778c.

Zhang, Z., Chen, Y.C., Cheng, Y.H., Luan, Y., & Yoon, E. (2016). Microfluidics 3D gel-island chip for single cell isolation and lineage-dependent drug responses study. Lab Chip, 16(13), 2504-2512.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc00081a.

Burgos-Ojeda, D., Wu, R., McLean, K., Chen, Y.C., Talpaz, M., Yoon, E., Cho, K.R., & Buckanovich, R.J. (2015). CD24+ Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis. Mol Cancer Ther, 14(7), 1717-1727.American Association for Cancer Research (AACR). doi: 10.1158/1535-7163.MCT-14-0607.

Chen, Y.C., Allen, S.G., Ingram, P.N., Buckanovich, R., Merajver, S.D., & Yoon, E. (2015). Single-cell Migration Chip for Chemotaxis-based Microfluidic Selection of Heterogeneous Cell Populations. Sci Rep, 5(1), 9980.Springer Nature. doi: 10.1038/srep09980.

Chen, Y.C., Kang, T.H., Ingram, P.N., Cheng, Y.H., & Yoon, E. (2015). Osmotically Actuated Micropumps and Control Valves for Point-of-Care Applications. Journal of Microelectromechanical Systems, 24(4), 982-989.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/jmems.2014.2364051.

Chen, Y.C., Lou, X., Zhang, Z., Ingram, P., & Yoon, E. (2015). High-Throughput Cancer Cell Sphere Formation for Characterizing the Efficacy of Photo Dynamic Therapy in 3D Cell Cultures. Sci Rep, 5(1), 12175.Springer Nature. doi: 10.1038/srep12175.

Chen, Y.C., Cheng, Y.H., Kim, H.S., Ingram, P.N., Nor, J.E., & Yoon, E. (2014). Paired single cell co-culture microenvironments isolated by two-phase flow with continuous nutrient renewal. Lab Chip, 14(16), 2941-2947.Royal Society of Chemistry (RSC). doi: 10.1039/c4lc00391h.

Chen, Y.C., Ingram, P., & Yoon, E. (2014). Electrolytic valving isolation of cell co-culture microenvironment with controlled cell pairing ratios. Analyst, 139(24), 6371-6378.Royal Society of Chemistry (RSC). doi: 10.1039/c4an01282h.

Yoon, H.K., Lou, X., Chen, Y.C., Koo Lee, Y.E., Yoon, E., & Kopelman, R. (2014). Nano-photosensitizers Engineered to Generate a Tunable Mix of Reactive Oxygen Species, for Optimizing Photodynamic Therapy, Using a Microfluidic Device. Chem Mater, 26(4), 1592-1600.American Chemical Society (ACS). doi: 10.1021/cm403505s.

Baac, H.W., Ok, J.G., Maxwell, A., Lee, K.T., Chen, Y.C., Hart, A.J., Xu, Z., Yoon, E., & Guo, L.J. (2012). Carbon-nanotube optoacoustic lens for focused ultrasound generation and high-precision targeted therapy. Sci Rep, 2(1), 989.Springer Nature. doi: 10.1038/srep00989.