Bachelor, Electrical Engineering, National Taiwan University, 2003 - 2008
Bachelor, Law, National Taiwan University, 2003 - 2008
Master, Electrical Engineering and Computer Science, University of Michigan–Ann Arbor, 2009 - 2012
PhD, Electrical Engineering and Computer Science, University of Michigan–Ann Arbor, 2009 - 2014
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Zhou, M., Ma, Y., Chiang, C.C., Rock, E.C., Luker, K.E., Luker, G.D., & Chen, Y.C. (2023). High-Throughput Cellular Heterogeneity Analysis in Cell Migration at the Single-Cell Level. Small, 19(6), e2206754.Wiley. doi: 10.1002/smll.202206754.
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Chen, Y.C., Jung, S., Zhang, Z., Wicha, M.S., & Yoon, E. (2019). Co-culture of functionally enriched cancer stem-like cells and cancer-associated fibroblasts for single-cell whole transcriptome analysis. Integr Biol (Camb), 11(9), 353-361.Oxford University Press (OUP). doi: 10.1093/intbio/zyz029.
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Humphries, B.A., Buschhaus, J.M., Chen, Y.C., Haley, H.R., Qyli, T., Chiang, B., Shen, N., Rajendran, S., Cutter, A., Cheng, Y.H., Chen, Y.T., Cong, J., Spinosa, P.C., Yoon, E., Luker, K.E., & Luker, G.D. (2019). Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer. Mol Cancer Res, 17(5), 1142-1154.American Association for Cancer Research (AACR). doi: 10.1158/1541-7786.MCR-18-0836.
Zhang, Z., Chen, L., Wang, Y., Zhang, T., Chen, Y.C., & Yoon, E. (2019). Label-Free Estimation of Therapeutic Efficacy on 3D Cancer Spheres Using Convolutional Neural Network Image Analysis. Anal Chem, 91(21), 14093-14100.American Chemical Society (ACS). doi: 10.1021/acs.analchem.9b03896.
Anwar, T., Arellano-Garcia, C., Ropa, J., Chen, Y.C., Kim, H.S., Yoon, E., Grigsby, S., Basrur, V., Nesvizhskii, A.I., Muntean, A., Gonzalez, M.E., Kidwell, K.M., Nikolovska-Coleska, Z., & Kleer, C.G. (2018). p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis. Nat Commun, 9(1), 2801.Springer Nature. doi: 10.1038/s41467-018-05078-8.
Chen, Y.C., Humphries, B., Brien, R., Gibbons, A.E., Chen, Y.T., Qyli, T., Haley, H.R., Pirone, M.E., Chiang, B., Xiao, A., Cheng, Y.H., Luan, Y., Zhang, Z., Cong, J., Luker, K.E., Luker, G.D., & Yoon, E. (2018). Functional Isolation of Tumor-Initiating Cells using Microfluidic-Based Migration Identifies Phosphatidylserine Decarboxylase as a Key Regulator. Sci Rep, 8(1), 244.Springer Nature. doi: 10.1038/s41598-017-18610-5.
Menon, R., Otto, E.A., Kokoruda, A., Zhou, J., Zhang, Z., Yoon, E., Chen, Y.C., Troyanskaya, O., Spence, J.R., Kretzler, M., & Cebrián, C. (2018). Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney. Development, 145(16), dev164038.The Company of Biologists. doi: 10.1242/dev.164038.
Zhang, Z., Chen, L., Humphries, B., Brien, R., Wicha, M.S., Luker, K.E., Luker, G.D., Chen, Y.C., & Yoon, E. (2018). Morphology-based prediction of cancer cell migration using an artificial neural network and a random decision forest. Integr Biol (Camb), 10(12), 758-767.Oxford University Press (OUP). doi: 10.1039/c8ib00106e.
Zhang, Z., Chen, Y.C., Urs, S., Chen, L., Simeone, D.M., & Yoon, E. (2018). Scalable Multiplexed Drug-Combination Screening Platforms Using 3D Microtumor Model for Precision Medicine. Small, 14(42), e1703617.Wiley. doi: 10.1002/smll.201703617.
Chen, Y.C., Baac, H.W., Lee, K.T., Fouladdel, S., Teichert, K., Ok, J.G., Cheng, Y.H., Ingram, P.N., Hart, A.J., Azizi, E., Guo, L.J., Wicha, M.S., & Yoon, E. (2017). Selective Photomechanical Detachment and Retrieval of Divided Sister Cells from Enclosed Microfluidics for Downstream Analyses. ACS Nano, 11(5), 4660-4668.American Chemical Society (ACS). doi: 10.1021/acsnano.7b00413.
Gonzalez, M.E., Martin, E.E., Anwar, T., Arellano-Garcia, C., Medhora, N., Lama, A., Chen, Y.C., Tanager, K.S., Yoon, E., Kidwell, K.M., Ge, C., Franceschi, R.T., & Kleer, C.G. (2017). Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. Cell Rep, 18(5), 1215-1228.Elsevier. doi: 10.1016/j.celrep.2016.12.079.
Kim, H.S., Chen, Y.C., Nör, F., Warner, K.A., Andrews, A., Wagner, V.P., Zhang, Z., Zhang, Z., Martins, M.D., Pearson, A.T., Yoon, E., & Nör, J.E. (2017). Endothelial-derived interleukin-6 induces cancer stem cell motility by generating a chemotactic gradient towards blood vessels. Oncotarget, 8(59), 100339-100352.Impact Journals. doi: 10.18632/oncotarget.22225.
Allen, S.G., Chen, Y.C., Madden, J.M., Fournier, C.L., Altemus, M.A., Hiziroglu, A.B., Cheng, Y.H., Wu, Z.F., Bao, L., Yates, J.A., Yoon, E., & Merajver, S.D. (2016). Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling. Sci Rep, 6(1), 39190.Springer Nature. doi: 10.1038/srep39190.
Bai, S., Ingram, P., Chen, Y.C., Deng, N., Pearson, A., Niknafs, Y.S., O'Hayer, P., Wang, Y., Zhang, Z.Y., Boscolo, E., Bischoff, J., Yoon, E., & Buckanovich, R.J. (2016). EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells. Cancer Res, 76(21), 6396-6409.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-16-0225.
Chen, Y.C., Cheng, Y.H., Ingram, P., & Yoon, E. (2016). Single Cell Proteolytic Assays to Investigate Cancer Clonal Heterogeneity and Cell Dynamics Using an Efficient Cell Loading Scheme. Sci Rep, 6(1), 27154.Springer Nature. doi: 10.1038/srep27154.
Chen, Y.C., Ingram, P.N., Fouladdel, S., McDermott, S.P., Azizi, E., Wicha, M.S., & Yoon, E. (2016). High-Throughput Single-Cell Derived Sphere Formation for Cancer Stem-Like Cell Identification and Analysis. Sci Rep, 6(1), 27301.Springer Nature. doi: 10.1038/srep27301.
Chen, Y.C., Zhang, Z., Fouladdel, S., Deol, Y., Ingram, P.N., McDermott, S.P., Azizi, E., Wicha, M.S., & Yoon, E. (2016). Single cell dual adherent-suspension co-culture micro-environment for studying tumor-stromal interactions with functionally selected cancer stem-like cells. Lab Chip, 16(15), 2935-2945.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc00062b.
Cheng, Y.H., Chen, Y.C., Brien, R., & Yoon, E. (2016). Scaling and automation of a high-throughput single-cell-derived tumor sphere assay chip. Lab Chip, 16(19), 3708-3717.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc00778c.
Zhang, Z., Chen, Y.C., Cheng, Y.H., Luan, Y., & Yoon, E. (2016). Microfluidics 3D gel-island chip for single cell isolation and lineage-dependent drug responses study. Lab Chip, 16(13), 2504-2512.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc00081a.
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Chen, Y.C., Allen, S.G., Ingram, P.N., Buckanovich, R., Merajver, S.D., & Yoon, E. (2015). Single-cell Migration Chip for Chemotaxis-based Microfluidic Selection of Heterogeneous Cell Populations. Sci Rep, 5(1), 9980.Springer Nature. doi: 10.1038/srep09980.
Chen, Y.C., Kang, T.H., Ingram, P.N., Cheng, Y.H., & Yoon, E. (2015). Osmotically Actuated Micropumps and Control Valves for Point-of-Care Applications. Journal of Microelectromechanical Systems, 24(4), 982-989.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/jmems.2014.2364051.
Chen, Y.C., Lou, X., Zhang, Z., Ingram, P., & Yoon, E. (2015). High-Throughput Cancer Cell Sphere Formation for Characterizing the Efficacy of Photo Dynamic Therapy in 3D Cell Cultures. Sci Rep, 5(1), 12175.Springer Nature. doi: 10.1038/srep12175.
Chen, Y.C., Cheng, Y.H., Kim, H.S., Ingram, P.N., Nor, J.E., & Yoon, E. (2014). Paired single cell co-culture microenvironments isolated by two-phase flow with continuous nutrient renewal. Lab Chip, 14(16), 2941-2947.Royal Society of Chemistry (RSC). doi: 10.1039/c4lc00391h.
Chen, Y.C., Ingram, P., & Yoon, E. (2014). Electrolytic valving isolation of cell co-culture microenvironment with controlled cell pairing ratios. Analyst, 139(24), 6371-6378.Royal Society of Chemistry (RSC). doi: 10.1039/c4an01282h.
Yoon, H.K., Lou, X., Chen, Y.C., Koo Lee, Y.E., Yoon, E., & Kopelman, R. (2014). Nano-photosensitizers Engineered to Generate a Tunable Mix of Reactive Oxygen Species, for Optimizing Photodynamic Therapy, Using a Microfluidic Device. Chem Mater, 26(4), 1592-1600.American Chemical Society (ACS). doi: 10.1021/cm403505s.
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