(2018 - 2023) NIH Director's New Innovator Award.
PhD, Carnegie Mellon University, 2005 - 2009
MS, Carnegie Mellon University, 2005 - 2008
SB, Massachusetts Institute of Technology, 1998 - 2002
Heyde, K.C., Scott, F.Y., Paek, S.H., Zhang, R., & Ruder, W.C. (2017). Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials. J Vis Exp, 2017(121).MyJove. doi: 10.3791/55300.
Lake, J.R., Heyde, K.C., & Ruder, W.C. (2017). Low-cost feedback-controlled syringe pressure pumps for microfluidics applications. In Wanunu, M. (Ed.). PLoS One, 12(4), e0175089.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0175089.
Heyde, K.C., & Ruder, W.C. (2016). A Model of a Synthetic Biological Communication Interface between Mammalian Cells and Mechatronic Systems. IEEE Trans Nanobioscience, 15(8), 864-870.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TNB.2016.2620942.
Heyde, K.C., Gallagher, P.W., & Ruder, W.C. (2016). Bioinspired decision architectures containing host and microbiome processing units. Bioinspir Biomim, 11(5), 056017.IOP Publishing. doi: 10.1088/1748-3190/11/5/056017.
Zhang, R., Heyde, K.C., Scott, F.Y., Paek, S.H., & Ruder, W.C. (2016). Programming Surface Chemistry with Engineered Cells. ACS Synth Biol, 5(9), 936-941.American Chemical Society (ACS). doi: 10.1021/acssynbio.6b00037.
González, L.M., Ruder, W.C., Mitchell, A.P., Messner, W.C., & LeDuc, P.R. (2015). Sudden motility reversal indicates sensing of magnetic field gradients in Magnetospirillum magneticum AMB-1 strain. ISME J, 9(6), 1399-1409.Oxford University Press (OUP). doi: 10.1038/ismej.2014.224.
Heyde, K.C., & Ruder, W.C. (2015). Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells. Sci Rep, 5(1), 11988.Springer Nature. doi: 10.1038/srep11988.
González, L.M., Ruder, W.C., Leduc, P.R., & Messner, W.C. (2014). Controlling magnetotactic bacteria through an integrated nanofabricated metallic island and optical microscope approach. Sci Rep, 4(1), 4104.Springer Nature. doi: 10.1038/srep04104.
Rice, M.K., & Ruder, W.C. (2014). Creating biological nanomaterials using synthetic biology. Sci Technol Adv Mater, 15(1), 014401.Taylor & Francis. doi: 10.1088/1468-6996/15/1/014401.
Ruder, W.C., & LeDuc, P.R. (2012). Cells gain traction in 3D. Proc Natl Acad Sci U S A, 109(28), 11060-11061.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1208617109.
Ruder, W.C., Hsu, C.P.D., Edelman, B.D., Schwartz, R., & Leduc, P.R. (2012). Biological colloid engineering: Self-assembly of dipolar ferromagnetic chains in a functionalized biogenic ferrofluid. Appl Phys Lett, 101(6), 63701.AIP Publishing. doi: 10.1063/1.4742329.
Ruder, W.C., Pratt, E.D., Bakhru, S., Sitti, M., Zappe, S., Cheng, C.M., Antaki, J.F., & LeDuc, P.R. (2012). Three-dimensional microfiber devices that mimic physiological environments to probe cell mechanics and signaling. Lab Chip, 12(10), 1775-1779.Royal Society of Chemistry (RSC). doi: 10.1039/c2lc21117c.
Ruder, W.C., Pratt, E.D., Brandy, N.Z.D., LaVan, D.A., LeDuc, P.R., & Antaki, J.F. (2012). Calcium signaling is gated by a mechanical threshold in three-dimensional environments. Sci Rep, 2(1), 554.Springer Nature. doi: 10.1038/srep00554.
Ruder, W.C., Lu, T., & Collins, J.J. (2011). Synthetic biology moving into the clinic. Science, 333(6047), 1248-1252.American Association for the Advancement of Science (AAAS). doi: 10.1126/science.1206843.
Kuczenski, B., Ruder, W.C., Messner, W.C., & Leduc, P.R. (2009). Probing cellular dynamics with a chemical signal generator. In Rojas, M. (Ed.). PLoS One, 4(3), e4847.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0004847.
Zhang, Y., Ruder, W.C., & LeDuc, P.R. (2008). Artificial cells: building bioinspired systems using small-scale biology. Trends Biotechnol, 26(1), 14-20.Elsevier. doi: 10.1016/j.tibtech.2007.09.006.
Gerbino, A., Ruder, W.C., Curci, S., Pozzan, T., Zaccolo, M., & Hofer, A.M. (2005). Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations. J Cell Biol, 171(2), 303-312.Rockefeller University Press. doi: 10.1083/jcb.200507054.
Lau, B.W., Colella, M., Ruder, W.C., Ranieri, M., Curci, S., & Hofer, A.M. (2005). Deoxycholic acid activates protein kinase C and phospholipase C via increased Ca2+ entry at plasma membrane. Gastroenterology, 128(3), 695-707.Elsevier. doi: 10.1053/j.gastro.2004.12.046.
Gonzalez, L.M., Tan, C., LeDuc, P.R., Messner, W.C., & Ruder, W.C. (2013). Controlled Envelopment of Magnetic Particles within Liposomes using a Custom-Built Multi-Layer Magnetic Microfluidic Device. In BIOPHYSICAL JOURNAL, 104(2), (p. 546A).Elsevier. doi: 10.1016/j.bpj.2012.11.3024.
Wilson, M.E., Gonzalez, L.M., LeDuc, P.R., & Ruder, W.C. (2013). Exploring the Mechanics of Magnetically Driven Motility in Magnetotactic Bacteria through Genetic Regulation. In BIOPHYSICAL JOURNAL, 104(2), (pp. 640A-641A).Elsevier. doi: 10.1016/j.bpj.2012.11.3538.
González, L.M., Ruder, W.C., Messner, W.C., & LeDuc, P.R. (2012). Sensing of Local, Highly Concentrated Magnetic Field Gradients in Magnetotactic Bacteria Induces Motility Reversal. In ASME 2012 Summer Bioengineering Conference, Parts A and B, (pp. 1297-1298).ASME International. doi: 10.1115/sbc2012-80447.
Gonzalez, L.M., Ruder, W.C., Zenkov, E., LeDuc, P.R., & Messner, W.C. (2012). Integrated Global and Local Field Sensing in Magnetospirillum Magnetotacticum. In BIOPHYSICAL JOURNAL, 102(3), (p. 415A).Elsevier. doi: 10.1016/j.bpj.2011.11.2271.
Wilson, M.E., González, L.M., Ruder, W.C., & LeDuc, P.R. (2012). Engineering Magnetic Nanomaterial Production in Magnetotactic Bacteria Through Gene Regulation. In ASME 2012 Summer Bioengineering Conference, Parts A and B, (pp. 349-350).ASME International. doi: 10.1115/sbc2012-80446.
Wilson, M.E., Ruder, W.C., Zenkov, E., Gonzalez, L.M., & Leduc, P.R. (2012). Magnetically-Induced Genetic Response of Magnetotactic Bacteria. In BIOPHYSICAL JOURNAL, 102(3), (p. 731A).Elsevier. doi: 10.1016/j.bpj.2011.11.3966.
Gonzalez, L.M., Ruder, W.C., Chou, S., Zenkov, E., Messner, W., & LeDuc, P.R. (2011). Imposing Local Magnetic Fields to Control Magnetotactic Bacteria Through Combining Microfabrication and Magnetism. In BIOPHYSICAL JOURNAL, 100(3), (p. 514).
González, L.M., Ruder, W.C., Zenkov, E., LeDuc, P.R., & Messner, W.C. (2011). Controlling Swimming Magnetotactic Bacteria Through Microfabrication Toward a Non-Destructive Biological Sensor. In ASME 2011 Summer Bioengineering Conference, Parts A and B, (PARTS A AND B), (pp. 421-422).ASME International. doi: 10.1115/sbc2011-53336.
Ruder, W.C., Hsu, C.P., Chou, S.Y., Dawson, J.T., Gonzalez, L.M., Antaki, J.F., & LeDuc, P.R. (2010). Micropatterning Biomanufactured Single-Domain Nanoparticles using Self-Assembly to form Artificial Magnetosome Chains. In BIOPHYSICAL JOURNAL, 98(3), (p. 730A).Elsevier. doi: 10.1016/j.bpj.2009.12.4001.
Ruder, W.C., Pratt, E.D., Sitti, M., Leduc, P.R., & Antaki, J.F. (2009). Investigation of calcium mechanotransduction by quasi 3-D microfiber mechanical stimulation of cells. In Proceedings of the ASME Summer Bioengineering Conference, SBC2008, (PART B), (pp. 1049-1050).
Zapanta, C., Ruder, W., Newberg, J., Glass, P., Minhas, D., Osuna, E.G., Sun, L.T., Siefert, A., Shum, J., Taylor, P., Drummond, A., & Chu, B. (2009). An integrated undergraduate biomedical engineering laboratory course. In ASEE Annual Conference and Exposition, Conference Proceedings.
Zapanta, C., Ruder, W., Newberg, J., Glass, P., Minhas, D., Osuna, E.G., Sun, L.T., Siefert, A., Shum, J., Taylor, P., Drummond, A., & Chu, B. (2009). An integrated undergraduate biomedical engineering laboratory course. In ASEE Annual Conference and Exposition, Conference Proceedings.
Ruder, W.C., Pratt, E.D., Brandy, N.Z., LaVan, D.A., LeDuc, P.R., & Antaki, J.F. (2007). Stretch-Activated Calcium Signal Propagation Following Mechanical Stimulation of Focal Adhesions. In ASME 2007 Summer Bioengineering Conference, (pp. 271-272).ASME International. doi: 10.1115/sbc2007-176431.