(2024) Elected as a Fellow of the American Association of Pharmaceutical Scientists (AAPS).
(2022) Inducted into the National Academy of Inventors (NAI).
(2022) Elected as a Fellow of the American Institute for the Advancement of Science (AAAS).
(2021) Distinguished Service Award, Controlled Release Society.
(2021) Appointed to the Special Faculty Rank of "Distinguished Professor" by the Chancellor of the University of Pittsburgh.
(2020) Elected as a Fellow of the Controlled Release Society (CRS).
(2020) Reappointed as the William Kepler Whiteford Endowed Professor.
(2019) Chancellor's Distinguished Public Service Award of the University of Pittsburgh.
(2018) Controlled Release Society Young Investigator Award.
(2018) American Chemical Society "Pittsburgh Award".
(2017) J Douglas Faires Memorial Colloquium Speaker Award of Youngstown State Univeristy.
(2017) Pittsburgh Business Times Innovation Award.
(2016) Elected as a Fellow of the American Institute for Medical and Biological Engineering (AIMBE).
(2015) Named "Fellow of the University Honors College", University of Pittsburgh.
(2015) The Carnegie Science Award in the Category of Advanced Materials.
(2015) Curtis W. McGraw Research Award - American Society for Engineering Education.
(2015) Selected one of the Pittsburgh Business Times' Fast Trackers (University Leaders).
(2015) Named William Kepler Whiteford Endowed Professor of Chemical and Petroleum Engineering.
(2015) Elected as a Fellow of the Biomedical Engineering Society (BMES).
(2014) Institute for Clinical Research Distinguished Alumni Award.
(2014) Named One of Five Pittsburgh "Disruptors" Who are "Shaking Up the Status Quo and Reshaping Our World" by Pop City Pittsburgh.
(2014) Selected as one of Pittsburgh Magazine's "40 under 40".
(2014) Phase II Coulter Translational Research Award.
(2014) Research to Prevent Blindness - Innovative Ophthalmic Research Award.
(2013) Chancellors Distinguished Teaching Award.
(2013) Carnegie Science Award in the Category of University Educator.
(2012) Best Diversity Mentor Award.
(2012) Invited Participant, NAE's Frontiers of Engineering Symposium.
(2012) Chancellor's Distinguished Research Award.
(2012) Society for Biomaterials Young Investigator Award.
(2012) Pitt Innovator Award.
(2012) Camille Dreyfus Teacher-Scholar.
(2010) Phase I Coulter Translational Research Award.
(2010) Most Outstanding Young Alumni.
(2009) Board of Visitor's Award - Most Outstanding Faculty Member in the School of Engineering.
(2009) Distinguished Faculty Fellowship.
(2008) Beckman Foundation Young Investigator Award.
(2008) ICRE Award.
(2007) AHA Career Development Award.
(2007) Distinguished Faculty Fellowship.
(2007) NIH K-Award.
(2005) AAAS Excellence in Research Award.
(2000 - 2003) National Science Foundation Graduate Fellow.
(2000) Tau Beta Pi Graduate Fellow.
(2000) Phi Kappa Phi Mavrigian-Grim Graduate Fellow.
(1999) ACS Organic Chemistry Award.
(1999) AIChE Professional Promise Award.
(1999) Eugene D. Scudder Physical Chemistry Award.
PhD, Chemical Engineering, Massachusetts Institute of Technology, 2005
BS, Chemical Engineering, Youngstown State University, 2000
Bentley, E.R., Subick, S., Doran, J., Kobyra, J., Balmert, S.C., & Little, S.R. (2025). Local delivery of an adenosine receptor agonist reduces inflammation associated with contact hypersensitivity. Drug Deliv Transl Res, 1-16.Springer Science and Business Media LLC. doi: 10.1007/s13346-025-01831-x.
Dunn, P.J., Mohammadzadeh, A., Pamuru, S.T., Butkus, C.R., Weitzman, J.N., Tian, Q., Yonet Tanyeri, N., Dalton, L.E., Elliott, E.M., Little, S.R., & Gilbertson, L.M. (2025). A Liposomal Carrier to Reduce Leaching of Ionic Nutrient Loads in Agricultural Soils. Environ Sci Technol.American Chemical Society (ACS). doi: 10.1021/acs.est.4c14370.
Naaz, A., Turnquist, H.R., Gorantla, V.S., & Little, S.R. (2024). Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap. Adv Drug Deliv Rev, 213, 115429.Elsevier. doi: 10.1016/j.addr.2024.115429.
Shehabeldin, M., Gao, J., Cho, Y., Chong, R., Tabib, T., Li, L., Smardz, M., Gaffen, S.L., Diaz, P.I., Lafyatis, R., Little, S.R., & Sfeir, C. (2024). Therapeutic delivery of CCL2 modulates immune response and restores host-microbe homeostasis. Proc Natl Acad Sci U S A, 121(36), e2400528121.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.2400528121.
Acharya, A.P., Sezginel, K.B., Gideon, H.P., Greene, A.C., Lawson, H.D., Inamdar, S., Tang, Y., Fraser, A.J., Patel, K.V., Liu, C., Rosi, N.L., Chan, S.Y., Flynn, J.L., Wilmer, C.E., & Little, S.R. (2022). In silico identification and synthesis of a multi-drug loaded MOF for treating tuberculosis. J Control Release, 352, 242-255.Elsevier. doi: 10.1016/j.jconrel.2022.10.024.
Greene, A.C., Shehabeldin, M., Gao, J., Balmert, S.C., Ratay, M., Sfeir, C., & Little, S.R. (2022). Local induction of regulatory T cells prevents inflammatory bone loss in ligature-induced experimental periodontitis in mice. Sci Rep, 12(1), 5032.Springer Nature. doi: 10.1038/s41598-022-09150-8.
Schilling, A.L., Cannon, E., Fullerton-Shirey, S.K., Lee, S.E., Wang, E.W., & Little, S.R. (2022). A ready-to-use, thermoresponsive, and extended-release delivery system for the paranasal sinuses. Drug Deliv Transl Res, 12(3), 708-719.Springer Nature. doi: 10.1007/s13346-021-01069-3.
Schilling, A.L., Cannon, E., Lee, S.E., Wang, E.W., & Little, S.R. (2022). Advances in controlled drug delivery to the sinonasal mucosa. Biomaterials, 282, 121430.Elsevier. doi: 10.1016/j.biomaterials.2022.121430.
Yonet-Tanyeri, N., Amer, M., Balmert, S.C., Korkmaz, E., Falo, L.D., & Little, S.R. (2022). Microfluidic Systems For Manufacturing of Microparticle-Based Drug-Delivery Systems: Design, Construction, and Operation. ACS Biomater Sci Eng, 8(7), 2864-2877.American Chemical Society (ACS). doi: 10.1021/acsbiomaterials.2c00066.
Acharya, A.P., Tang, Y., Bertero, T., Tai, Y.Y., Harvey, L.D., Woodcock, C.S.C., Sun, W., Pineda, R., Mitash, N., Königshoff, M., Little, S.R., & Chan, S.Y. (2021). Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension. J Am Heart Assoc, 10(12), e019091.Wolters Kluwer. doi: 10.1161/JAHA.120.019091.
Bassin, E.J., Piganelli, J.D., & Little, S.R. (2021). Auto-antigen and Immunomodulatory Agent-Based Approaches for Antigen-Specific Tolerance in NOD Mice. Curr Diab Rep, 21(3), 9.Springer Nature. doi: 10.1007/s11892-021-01376-6.
Bellotti, E., Schilling, A.L., Little, S.R., & Decuzzi, P. (2021). Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: A review. J Control Release, 329, 16-35.Elsevier. doi: 10.1016/j.jconrel.2020.11.049.
Bentley, E.R., & Little, S.R. (2021). Local delivery strategies to restore immune homeostasis in the context of inflammation. Adv Drug Deliv Rev, 178, 113971.Elsevier. doi: 10.1016/j.addr.2021.113971.
Borrelli, M.A., Turnquist, H.R., & Little, S.R. (2021). Biologics and their delivery systems: Trends in myocardial infarction. Adv Drug Deliv Rev, 173, 181-215.Elsevier. doi: 10.1016/j.addr.2021.03.014.
Greene, A.C., Acharya, A.P., Lee, S.B., Gottardi, R., Zaleski, E., & Little, S.R. (2021). Cranberry extract-based formulations for preventing bacterial biofilms. Drug Deliv Transl Res, 11(3), 1144-1155.Springer Nature. doi: 10.1007/s13346-020-00837-x.
Lorentz, K.L., Gupta, P., Shehabeldin, M.S., Cunnane, E.M., Ramaswamy, A.K., Verdelis, K., DiLeo, M.V., Little, S.R., Weinbaum, J.S., Sfeir, C.S., Mandal, B.B., & Vorp, D.A. (2021). CCL2 loaded microparticles promote acute patency in silk-based vascular grafts implanted in rat aortae. Acta Biomater, 135, 126-138.Elsevier. doi: 10.1016/j.actbio.2021.08.049.
Pacheco, C.M.F., Maltos, K.L.M., Shehabeldin, M.S., Thomas, L.L., Zhuang, Z., Yoshizawa, S., Verdelis, K., Gaffen, S.L., Garlet, G.P., Little, S.R., & Sfeir, C. (2021). Local Sustained Delivery of Anti-IL-17A Antibodies Limits Inflammatory Bone Loss in Murine Experimental Periodontitis. J Immunol, 206(10), 2386-2392.Oxford University Press (OUP). doi: 10.4049/jimmunol.2001432.
Patel, S.K., Greene, A.C., Desai, S.M., Rothstein, S., Basha, I.T., MacPherson, J.S., Wang, Y., Zou, Y., Shehabeldin, M., Sfeir, C.S., Little, S.R., & Rohan, L.C. (2021). Biorelevant and screening dissolution methods for minocycline hydrochloride microspheres intended for periodontal administration. Int J Pharm, 596, 120261.Elsevier. doi: 10.1016/j.ijpharm.2021.120261.
Schilling, A.L., Carcella, A.R., Moore, J., Zahid, M., Lo, C., Wang, E.W., Lee, S.E., & Little, S.R. (2021). Compatibility of a Thermoresponsive and Controlled Release System for Promoting Sinonasal Cilia Regeneration. Macromol Biosci, 21(11), e2100277.Wiley. doi: 10.1002/mabi.202100277.
Schilling, A.L., Kulahci, Y., Moore, J., Wang, E.W., Lee, S.E., & Little, S.R. (2021). A thermoresponsive hydrogel system for long-acting corticosteroid delivery into the paranasal sinuses. J Control Release, 330, 889-897.Elsevier. doi: 10.1016/j.jconrel.2020.10.062.
Schilling, A.L., Little, S.R., Wang, E.W., & Lee, S.E. (2021). Reply: A preclinical model to tackle chronic rhinosinusitis. Int Forum Allergy Rhinol, 11(4), 828-829.Wiley. doi: 10.1002/alr.22769.
Schilling, A.L., Moore, J., Kulahci, Y., Little, S.R., Rigatti, L.H., Wang, E.W., & Lee, S.E. (2021). Evaluating inflammation in an obstruction-based chronic rhinosinusitis model in rabbits. Int Forum Allergy Rhinol, 11(4), 807-809.Wiley. doi: 10.1002/alr.22729.
Yonet-Tanyeri, N., Ahlmark, B.Z., & Little, S.R. (2021). Advances in Multiplexed Paper-Based Analytical Devices for Cancer Diagnosis: A Review of Technological Developments. Adv Mater Technol, 6(8), 2001138.Wiley. doi: 10.1002/admt.202001138.
Bassin, E.J., Buckley, A.R., Piganelli, J.D., & Little, S.R. (2020). TRI microparticles prevent inflammatory arthritis in a collagen-induced arthritis model. In Choi, J.M. (Ed.). PLoS One, 15(9), e0239396.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0239396.
Ding, X., Gao, J., Acharya, A.P., Wu, Y.L., Little, S.R., & Wang, Y. (2020). Azido-Functionalized Polyurethane Designed for Making Tunable Elastomers by Click Chemistry. ACS Biomater Sci Eng, 6(2), 852-864.American Chemical Society (ACS). doi: 10.1021/acsbiomaterials.9b01357.
Fisher, J.D., Zhang, W., Balmert, S.C., Aral, A.M., Acharya, A.P., Kulahci, Y., Li, J., Turnquist, H.R., Thomson, A.W., Solari, M.G., Gorantla, V.S., & Little, S.R. (2020). In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation. Sci Adv, 6(11), eaax8429.American Association for the Advancement of Science (AAAS). doi: 10.1126/sciadv.aax8429.
Sarmento, B., & Little, S. (2020). Fundamentals of nanomedicines towards clinical translation. Drug Deliv Transl Res, 10(3), 571.Springer Nature. doi: 10.1007/s13346-020-00762-z.
Bellotti, E., Fedorchak, M.V., Velankar, S., & Little, S.R. (2019). Tuning of thermoresponsive pNIPAAm hydrogels for the topical retention of controlled release ocular therapeutics. J Mater Chem B, 7(8), 1276-1283.Royal Society of Chemistry (RSC). doi: 10.1039/C8TB02976H.
de Campos Soriani Azevedo, M., Garlet, T.P., Francisconi, C.F., Colavite, P.M., Tabanez, A.P., Melchiades, J.L., Favaro Trombone, A.P., Sfeir, C., Little, S., Silva, R.M., & Garlet, G.P. (2019). Vasoactive Intestinal Peptide Immunoregulatory Role at the Periapex: Associative and Mechanistic Evidences from Human and Experimental Periapical Lesions. J Endod, 45(10), 1228-1236.Elsevier. doi: 10.1016/j.joen.2019.06.013.
Fisher, J.D., Balmert, S.C., Zhang, W., Schweizer, R., Schnider, J.T., Komatsu, C., Dong, L., Erbas, V.E., Unadkat, J.V., Aral, A.M., Acharya, A.P., Kulahci, Y., Turnquist, H.R., Thomson, A.W., Solari, M.G., Gorantla, V.S., & Little, S.R. (2019). Treg-inducing microparticles promote donor-specific tolerance in experimental vascularized composite allotransplantation. Proc Natl Acad Sci U S A, 116(51), 25784-25789.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1910701116.
Joseph, N., Lawson, H.D., Overholt, K.J., Damodaran, K., Gottardi, R., Acharya, A.P., & Little, S.R. (2019). Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications. Sci Rep, 9(1), 13024.Springer Nature. doi: 10.1038/s41598-019-49536-9.
Leong, H.S., Butler, K.S., Brinker, C.J., Azzawi, M., Conlan, S., Dufés, C., Owen, A., Rannard, S., Scott, C., Chen, C., Dobrovolskaia, M.A., Kozlov, S.V., Prina-Mello, A., Schmid, R., Wick, P., Caputo, F., Boisseau, P., Crist, R.M., McNeil, S.E., Fadeel, B., Tran, L., Hansen, S.F., Hartmann, N.B., Clausen, L.P.W., Skjolding, L.M., Baun, A., Ågerstrand, M., Gu, Z., Lamprou, D.A., Hoskins, C., Huang, L., Song, W., Cao, H., Liu, X., Jandt, K.D., Jiang, W., Kim, B.Y.S., Wheeler, K.E., Chetwynd, A.J., Lynch, I., Moghimi, S.M., Nel, A., Xia, T., Weiss, P.S., Sarmento, B., das Neves, J., Santos, H.A., Santos, L., Mitragotri, S., Little, S., Peer, D., Amiji, M.M., Alonso, M.J., Petri-Fink, A., Balog, S., Lee, A., Drasler, B., Rothen-Rutishauser, B., Wilhelm, S., Acar, H., Harrison, R.G., Mao, C., Mukherjee, P., Ramesh, R., McNally, L.R., Busatto, S., Wolfram, J., Bergese, P., Ferrari, M., Fang, R.H., Zhang, L., Zheng, J., Peng, C., Du, B., Yu, M., Charron, D.M., Zheng, G., & Pastore, C. (2019). On the issue of transparency and reproducibility in nanomedicine. Nat Nanotechnol, 14(7), 629-635.Springer Nature. doi: 10.1038/s41565-019-0496-9.
Leong, H.S., Butler, K.S., Brinker, C.J., Azzawi, M., Conlan, S., Dufès, C., Owen, A., Rannard, S., Scott, C., Chen, C., Dobrovolskaia, M.A., Kozlov, S.V., Prina-Mello, A., Schmid, R., Wick, P., Caputo, F., Boisseau, P., Crist, R.M., McNeil, S.E., Fadeel, B., Tran, L., Hansen, S.F., Hartmann, N.B., Clausen, L.P.W., Skjolding, L.M., Baun, A., Ågerstrand, M., Gu, Z., Lamprou, D.A., Hoskins, C., Huang, L., Song, W., Cao, H., Liu, X., Jandt, K.D., Jiang, W., Kim, B.Y.S., Wheeler, K.E., Chetwynd, A.J., Lynch, I., Moghimi, S.M., Nel, A., Xia, T., Weiss, P.S., Sarmento, B., das Neves, J., Santos, H.A., Santos, L., Mitragotri, S., Little, S., Peer, D., Amiji, M.M., Alonso, M.J., Petri-Fink, A., Balog, S., Lee, A., Drasler, B., Rothen-Rutishauser, B., Wilhelm, S., Acar, H., Harrison, R.G., Mao, C., Mukherjee, P., Ramesh, R., McNally, L.R., Busatto, S., Wolfram, J., Bergese, P., Ferrari, M., Fang, R.H., Zhang, L., Zheng, J., Peng, C., Du, B., Yu, M., Charron, D.M., Zheng, G., & Pastore, C. (2019). Publisher Correction: On the issue of transparency and reproducibility in nanomedicine. Nat Nanotechnol, 14(9), 902.Springer Nature. doi: 10.1038/s41565-019-0538-3.
Leong, H.S., Butler, K.S., Brinker, C.J., Azzawi, M., Conlan, S., Dufès, C., Owen, A., Rannard, S., Scott, C., Chen, C., Dobrovolskaia, M.A., Kozlov, S.V., Prina-Mello, A., Schmid, R., Wick, P., Caputo, F., Boisseau, P., Crist, R.M., McNeil, S.E., Fadeel, B., Tran, L., Hansen, S.F., Hartmann, N.B., Clausen, L.P.W., Skjolding, L.M., Baun, A., Ågerstrand, M., Gu, Z., Lamprou, D.A., Hoskins, C., Huang, L., Song, W., Cao, H., Liu, X., Jandt, K.D., Jiang, W., Kim, B.Y.S., Wheeler, K.E., Chetwynd, A.J., Lynch, I., Moghimi, S.M., Nel, A., Xia, T., Weiss, P.S., Sarmento, B., Neves, J.D., Santos, H.A., Santos, L., Mitragotri, S., Little, S., Peer, D., Amiji, M.M., Alonso, M.J., Petri-Fink, A., Balog, S., Lee, A., Drasler, B., Rothen-Rutishauser, B., Wilhelm, S., Acar, H., Harrison, R.G., Mao, C., Mukherjee, P., Ramesh, R., McNally, L.R., Busatto, S., Wolfram, J., Bergese, P., Ferrari, M., Fang, R.H., Zhang, L., Zheng, J., Peng, C., Du, B., Yu, M., Charron, D.M., Zheng, G., & Pastore, C. (2019). Publisher Correction: On the issue of transparency and reproducibility in nanomedicine. Nat Nanotechnol, 14(8), 811.Springer Nature. doi: 10.1038/s41565-019-0523-x.
Little, S.R. (2019). The current status and future directions of CRS Focus Groups. J Control Release, 300, 46-51.Elsevier. doi: 10.1016/j.jconrel.2019.02.020.
Zhuang, Z., Yoshizawa-Smith, S., Glowacki, A., Maltos, K., Pacheco, C., Shehabeldin, M., Mulkeen, M., Myers, N., Chong, R., Verdelis, K., Garlet, G.P., Little, S., & Sfeir, C. (2019). Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models. J Dent Res, 98(2), 200-208.SAGE Publications. doi: 10.1177/0022034518805984.
Francisconi, C.F., Vieira, A.E., Azevedo, M.C.S., Tabanez, A.P., Fonseca, A.C., Trombone, A.P.F., Letra, A., Silva, R.M., Sfeir, C.S., Little, S.R., & Garlet, G.P. (2018). RANKL Triggers Treg-Mediated Immunoregulation in Inflammatory Osteolysis. J Dent Res, 97(8), 917-927.SAGE Publications. doi: 10.1177/0022034518759302.
Fuller, T.W., Acharya, A.P., Meyyappan, T., Yu, M., Bhaskar, G., Little, S.R., & Tarin, T.V. (2018). Comparison of Bladder Carcinogens in the Urine of E-cigarette Users Versus Non E-cigarette Using Controls. Sci Rep, 8(1), 507.Springer Nature. doi: 10.1038/s41598-017-19030-1.
Hwang, M.P., Ding, X., Gao, J., Acharya, A.P., Little, S.R., & Wang, Y. (2018). A biocompatible betaine-functionalized polycation for coacervation. Soft Matter, 14(3), 387-395.Royal Society of Chemistry (RSC). doi: 10.1039/c7sm01763d.
Nichols, D.A., Sondh, I.S., Little, S.R., Zunino, P., & Gottardi, R. (2018). Correction to: Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis. Biomed Microdevices, 20(2), 39.Springer Nature. doi: 10.1007/s10544-018-0283-7.
Nichols, D.A., Sondh, I.S., Little, S.R., Zunino, P., & Gottardi, R. (2018). Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis. Biomed Microdevices, 20(1), 18.Springer Nature. doi: 10.1007/s10544-018-0264-x.
Ratay, M.L., Balmert, S.C., Bassin, E.J., & Little, S.R. (2018). Controlled release of an HDAC inhibitor for reduction of inflammation in dry eye disease. Acta Biomater, 71, 261-270.Elsevier. doi: 10.1016/j.actbio.2018.03.002.
Washington, M.A., Balmert, S.C., Fedorchak, M.V., Little, S.R., Watkins, S.C., & Meyer, T.Y. (2018). Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response. Acta Biomater, 65, 259-271.Elsevier. doi: 10.1016/j.actbio.2017.10.043.
Acharya, A.P., Sinha, M., Ratay, M.L., Ding, X., Balmert, S.C., Workman, C.J., Wang, Y., Vignali, D.A.A., & Little, S.R. (2017). Localized Multi-Component Delivery Platform Generates Local and Systemic Anti-Tumor Immunity. ADVANCED FUNCTIONAL MATERIALS, 27(5).Wiley. doi: 10.1002/adfm.201604366.
Acharya, A.P., Theisen, K.M., Correa, A., Meyyappan, T., Apfel, A., Sun, T., Tarin, T.V., & Little, S.R. (2017). An Inexpensive, Point-of-Care Urine Test for Bladder Cancer in Patients Undergoing Hematuria Evaluation. Adv Healthc Mater, 6(22).Wiley. doi: 10.1002/adhm.201700808.
Balmert, S.C., Donahue, C., Vu, J.R., Erdos, G., Falo, L.D., & Little, S.R. (2017). In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis. J Control Release, 261, 223-233.Elsevier. doi: 10.1016/j.jconrel.2017.07.006.
Bayer, E.A., Jordan, J., Roy, A., Gottardi, R., Fedorchak, M.V., Kumta, P.N., & Little, S.R. (2017). * Programmed Platelet-Derived Growth Factor-BB and Bone Morphogenetic Protein-2 Delivery from a Hybrid Calcium Phosphate/Alginate Scaffold. Tissue Eng Part A, 23(23-24), 1382-1393.Mary Ann Liebert. doi: 10.1089/ten.TEA.2017.0027.
Fedorchak, M.V., Conner, I.P., Schuman, J.S., Cugini, A., & Little, S.R. (2017). Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop. Sci Rep, 7(1), 8639.Springer Nature. doi: 10.1038/s41598-017-09379-8.
Ratay, M.L., Balmert, S.C., Acharya, A.P., Greene, A.C., Meyyappan, T., & Little, S.R. (2017). TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model. Sci Rep, 7(1), 17527.Springer Nature. doi: 10.1038/s41598-017-17869-y.
Ratay, M.L., Bellotti, E., Gottardi, R., & Little, S.R. (2017). Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation. Adv Healthc Mater, 6(23).Wiley. doi: 10.1002/adhm.201700733.
Ratay, M.L., Glowacki, A.J., Balmert, S.C., Acharya, A.P., Polat, J., Andrews, L.P., Fedorchak, M.V., Schuman, J.S., Vignali, D.A.A., & Little, S.R. (2017). Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease. J Control Release, 258, 208-217.Elsevier. doi: 10.1016/j.jconrel.2017.05.007.
Washington, M.A., Swiner, D.J., Bell, K.R., Fedorchak, M.V., Little, S.R., & Meyer, T.Y. (2017). The impact of monomer sequence and stereochemistry on the swelling and erosion of biodegradable poly(lactic-co-glycolic acid) matrices. Biomaterials, 117, 66-76.Elsevier. doi: 10.1016/j.biomaterials.2016.11.037.
Bayer, E.A., Fedorchak, M.V., & Little, S.R. (2016). The Influence of Platelet-Derived Growth Factor and Bone Morphogenetic Protein Presentation on Tubule Organization by Human Umbilical Vascular Endothelial Cells and Human Mesenchymal Stem Cells in Coculture. Tissue Eng Part A, 22(21-22), 1296-1304.Mary Ann Liebert. doi: 10.1089/ten.TEA.2016.0163.
Francisconi, C.F., Vieira, A.E., Biguetti, C.C., Glowacki, A.J., Trombone, A.P.F., Letra, A., Menezes Silva, R., Sfeir, C.S., Little, S.R., & Garlet, G.P. (2016). Characterization of the Protective Role of Regulatory T Cells in Experimental Periapical Lesion Development and Their Chemoattraction Manipulation as a Therapeutic Tool. J Endod, 42(1), 120-126.Elsevier. doi: 10.1016/j.joen.2015.09.022.
Roy, A., Jhunjhunwala, S., Bayer, E., Fedorchak, M., Little, S.R., & Kumta, P.N. (2016). Porous calcium phosphate-poly (lactic-co-glycolic) acid composite bone cement: A viable tunable drug delivery system. Mater Sci Eng C Mater Biol Appl, 59, 92-101.Elsevier. doi: 10.1016/j.msec.2015.09.081.
Acharya, A.P., & Little, S.R. (2015). Stapled endosome disrupting alginate particles for cytosolic delivery of cations. J Drug Target, 23(7-8), 690-697.Taylor & Francis. doi: 10.3109/1061186X.2015.1048517.
Araujo-Pires, A.C., Vieira, A.E., Francisconi, C.F., Biguetti, C.C., Glowacki, A., Yoshizawa, S., Campanelli, A.P., Trombone, A.P.F., Sfeir, C.S., Little, S.R., & Garlet, G.P. (2015). IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis. J Bone Miner Res, 30(3), 412-422.Oxford University Press (OUP). doi: 10.1002/jbmr.2376.
Balmert, S.C., Zmolek, A.C., Glowacki, A.J., Knab, T.D., Rothstein, S.N., Wokpetah, J.M., Fedorchak, M.V., & Little, S.R. (2015). Positive Charge of "Sticky" Peptides and Proteins Impedes Release From Negatively Charged PLGA Matrices. J Mater Chem B, 3(23), 4723-4734.Royal Society of Chemistry (RSC). doi: 10.1039/C5TB00515A.
Bayer, E.A., Gottardi, R., Fedorchak, M.V., & Little, S.R. (2015). The scope and sequence of growth factor delivery for vascularized bone tissue regeneration. J Control Release, 219, 129-140.Elsevier. doi: 10.1016/j.jconrel.2015.08.004.
Fisher, J.D., Acharya, A.P., & Little, S.R. (2015). Micro and nanoparticle drug delivery systems for preventing allotransplant rejection. Clin Immunol, 160(1), 24-35.Elsevier. doi: 10.1016/j.clim.2015.04.013.
Glowacki, A.J., Gottardi, R., Yoshizawa, S., Cavalla, F., Garlet, G.P., Sfeir, C., & Little, S.R. (2015). Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease. Ann Biomed Eng, 43(3), 593-602.Springer Nature. doi: 10.1007/s10439-014-1125-2.
Guaragno, M.L., Gottardi, R., Fedorchak, M.V., Roy, A., Kumta, P.N., & Little, S.R. (2015). One-step synthesis of fluorescently labelled, single-walled carbon nanotubes. Chem Commun (Camb), 51(97), 17233-17236.Royal Society of Chemistry (RSC). doi: 10.1039/c5cc05573c.
Knab, T.D., Little, S.R., & Parker, R.S. (2015). A systems approach to modeling drug release from polymer microspheres to accelerate in vitro to in vivo translation. J Control Release, 211, 74-84.Elsevier. doi: 10.1016/j.jconrel.2015.04.045.
Lash, M.H., Fedorchak, M.V., Little, S.R., & McCarthy, J.J. (2015). Fabrication and characterization of non-Brownian particle-based crystals. Langmuir, 31(3), 898-905.American Chemical Society (ACS). doi: 10.1021/la501511s.
Lash, M.H., Fedorchak, M.V., McCarthy, J.J., & Little, S.R. (2015). Scaling up self-assembly: bottom-up approaches to macroscopic particle organization. Soft Matter, 11(28), 5597-5609.Royal Society of Chemistry (RSC). doi: 10.1039/c5sm00764j.
Lash, M.H., Jordan, J.C., Blevins, L.C., Fedorchak, M.V., Little, S.R., & McCarthy, J.J. (2015). Non-Brownian particle-based materials with microscale and nanoscale hierarchy. Angew Chem Int Ed Engl, 54(20), 5854-5858.Wiley. doi: 10.1002/anie.201500273.
Lash, M.H., Jordan, J.C., Blevins, L.C., Fedorchak, M.V., Little, S.R., & McCarthy, J.J. (2015). Non‐Brownian Particle‐Based Materials with Microscale and Nanoscale Hierarchy. Angewandte Chemie, 127(20), 5952-5956.Wiley. doi: 10.1002/ange.201500273.
Fedorchak, M.V., Conner, I.P., Medina, C.A., Wingard, J.B., Schuman, J.S., & Little, S.R. (2014). 28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres. Exp Eye Res, 125, 210-216.Elsevier. doi: 10.1016/j.exer.2014.06.013.
Fu, H.L., Hong, Y., Little, S.R., & Wagner, W.R. (2014). Collagenase-labile polyurethane urea synthesis and processing into hollow fiber membranes. Biomacromolecules, 15(8), 2924-2932.American Chemical Society (ACS). doi: 10.1021/bm500552f.
Garlet, G.P., Sfeir, C.S., & Little, S.R. (2014). Restoring host-microbe homeostasis via selective chemoattraction of Tregs. J Dent Res, 93(9), 834-839.SAGE Publications. doi: 10.1177/0022034514544300.
Mealy, J.E., Fedorchak, M.V., & Little, S.R. (2014). In vitro characterization of a controlled-release ocular insert for delivery of brimonidine tartrate. Acta Biomater, 10(1), 87-93.Elsevier. doi: 10.1016/j.actbio.2013.09.024.
Rothstein, S.N., Donahue, C., Falo, L.D., & Little, S.R. (2014). In silico programming of degradable microparticles to hide and then reveal immunogenic payloads in vivo. J Mater Chem B, 2(37), 6183-6187.Royal Society of Chemistry (RSC). doi: 10.1039/c4tb01042f.
Rothstein, S.N., Huber, K.D., Sluis-Cremer, N., & Little, S.R. (2014). In vitro characterization of a sustained-release formulation for enfuvirtide. Antimicrob Agents Chemother, 58(3), 1797-1799.American Society for Microbiology. doi: 10.1128/AAC.02440-13.
Fedorchak, M., Cugini, A., Schuman, J., & Little, S. (2013). The Monthly Eye Drop: Development of a Long-term, Noninvasive Glaucoma Treatment System. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(15), 4294.
Glowacki, A.J., Yoshizawa, S., Jhunjhunwala, S., Vieira, A.E., Garlet, G.P., Sfeir, C., & Little, S.R. (2013). Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes. Proc Natl Acad Sci U S A, 110(46), 18525-18530.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1302829110.
Jhunjhunwala, S., Chen, L.C., Nichols, E.E., Thomson, A.W., Raimondi, G., & Little, S.R. (2013). All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities. J Leukoc Biol, 94(5), 981-989.Oxford University Press (OUP). doi: 10.1189/jlb.0312167.
Kamalasanan, K., Gottardi, R., Tan, S., Chen, Y., Godugu, B., Rothstein, S., Balazs, A.C., Star, A., & Little, S.R. (2013). "Zero-dimensional" single-walled carbon nanotubes. Angew Chem Int Ed Engl, 52(43), 11308-11312.Wiley. doi: 10.1002/anie.201305526.
Little, S. (2013). Foreword. 9781118098479, xi-xii.
Balmert, S.C., & Little, S.R. (2012). Biomimetic delivery with micro- and nanoparticles. Adv Mater, 24(28), 3757-3778.Wiley. doi: 10.1002/adma.201200224.
Eghtesad, S., Jhunjhunwala, S., Little, S.R., & Clemens, P.R. (2012). Effect of rapamycin on immunity induced by vector-mediated dystrophin expression in mdx skeletal muscle. Sci Rep, 2(1), 399.Springer Nature. doi: 10.1038/srep00399.
Jhunjhunwala, S., Balmert, S.C., Raimondi, G., Dons, E., Nichols, E.E., Thomson, A.W., & Little, S.R. (2012). Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells. J Control Release, 159(1), 78-84.Elsevier. doi: 10.1016/j.jconrel.2012.01.013.
Jhunjhunwala, S., Raimondi, G., Glowacki, A.J., Hall, S.J., Maskarinec, D., Thorne, S.H., Thomson, A.W., & Little, S.R. (2012). Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo. Adv Mater, 24(35), 4735-4738.Wiley. doi: 10.1002/adma.201202513.
Li, J., Rothstein, S.N., Little, S.R., Edenborn, H.M., & Meyer, T.Y. (2012). The effect of monomer order on the hydrolysis of biodegradable poly(lactic-co-glycolic acid) repeating sequence copolymers. J Am Chem Soc, 134(39), 16352-16359.American Chemical Society (ACS). doi: 10.1021/ja306866w.
Little, S. (2012). The importance of peer-review. Gen Dent, 60(4), 251.
Little, S.R. (2012). Reorienting our view of particle-based adjuvants for subunit vaccines. Proc Natl Acad Sci U S A, 109(4), 999-1000.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1120993109.
Rothstein, S.N., Kay, J.E., Schopfer, F.J., Freeman, B.A., & Little, S.R. (2012). A retrospective mathematical analysis of controlled release design and experimentation. Mol Pharm, 9(11), 3003-3011.American Chemical Society (ACS). doi: 10.1021/mp300388w.
Tengood, J.E., Maskarinec, D., Ridenour, R., & Little, S.R. (2012). A mathematical model for release of biologics from porous hollow fibers. J Biomed Mater Res A, 100(4), 817-826.Wiley. doi: 10.1002/jbm.a.34013.
Dutt, M., Kuksenok, O., Little, S.R., & Balazs, A.C. (2011). Forming transmembrane channels using end-functionalized nanotubes. Nanoscale, 3(1), 240-250.Royal Society of Chemistry (RSC). doi: 10.1039/c0nr00578a.
Dutt, M., Kuksenok, O., Nayhouse, M.J., Little, S.R., & Balazs, A.C. (2011). Modeling the self-assembly of lipids and nanotubes in solution: forming vesicles and bicelles with transmembrane nanotube channels. ACS Nano, 5(6), 4769-4782.American Chemical Society (ACS). doi: 10.1021/nn201260r.
Dutt, M., Nayhouse, M.J., Kuksenok, O., Little, S.R., & Balazs, A.C. (2011). Interactions of End-functionalized Nanotubes with Lipid Vesicles: Spontaneous Insertion and Nanotube Self-Organization. CURRENT NANOSCIENCE, 7(5), 699-715.Bentham Science Publishers. doi: 10.2174/157341311797483772.
Eghtesad, S., Jhunjhunwala, S., Little, S.R., & Clemens, P.R. (2011). Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle. Mol Med, 17(9-10), 917-924.Springer Nature. doi: 10.2119/molmed.2010.00256.
Jhunjhunwala, S., & Little, S.R. (2011). Microparticulate systems for targeted drug delivery to phagocytes. Cell Cycle, 10(13), 2047-2048.Taylor & Francis. doi: 10.4161/cc.10.13.15713.
Kamalasanan, K., Jhunjhunwala, S., Wu, J., Swanson, A., Gao, D., & Little, S.R. (2011). Patchy, anisotropic microspheres with soft protein islets. Angew Chem Int Ed Engl, 50(37), 8706-8708.Wiley. doi: 10.1002/anie.201101217.
Rothstein, S.N., & Little, S.R. (2011). A "tool box" for rational design of degradable controlled release formulations. JOURNAL OF MATERIALS CHEMISTRY, 21(1), 29-39.Royal Society of Chemistry (RSC). doi: 10.1039/c0jm01668c.
Tengood, J.E., Ridenour, R., Brodsky, R., Russell, A.J., & Little, S.R. (2011). Sequential delivery of basic fibroblast growth factor and platelet-derived growth factor for angiogenesis. Tissue Eng Part A, 17(9-10), 1181-1189.Mary Ann Liebert. doi: 10.1089/ten.TEA.2010.0551.
Alberto Fierro, J., Ramirez, V., Silva, C., Ruiz, P., Gleisner, A., Morales, J., Jhunjhunwala, S., Little, S.R., Rosa Bono, M., & Rosemblatt, M. (2010). Transference of Phagosomes in an Allogeneic Immunisation Protocol Down Regulates the Production of Anti-MHC Antibodies and T Cell Mediated Alloreactivity. AMERICAN JOURNAL OF TRANSPLANTATION, 10(14), 562.
Brito, L.A., Chandrasekhar, S., Little, S.R., & Amiji, M.M. (2010). Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis. Biomed Eng Online, 9(1), 56.Springer Nature. doi: 10.1186/1475-925X-9-56.
Brito, L.A., Chandrasekhar, S., Little, S.R., & Amiji, M.M. (2010). In vitro and in vivo studies of local arterial gene delivery and transfection using lipopolyplexes-embedded stents. J Biomed Mater Res A, 93(1), 325-336.Wiley. doi: 10.1002/jbm.a.32488.
Kokai, L.E., Tan, H., Jhunjhunwala, S., Little, S.R., Frank, J.W., & Marra, K.G. (2010). Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres. J Control Release, 141(2), 168-176.Elsevier. doi: 10.1016/j.jconrel.2009.09.003.
Tengood, J.E., Kovach, K.M., Vescovi, P.E., Russell, A.J., & Little, S.R. (2010). Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. Biomaterials, 31(30), 7805-7812.Elsevier. doi: 10.1016/j.biomaterials.2010.07.010.
van Vlerken, L.E., Duan, Z., Little, S.R., Seiden, M.V., & Amiji, M.M. (2010). Augmentation of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems. AAPS J, 12(2), 171-180.Springer Nature. doi: 10.1208/s12248-010-9174-4.
Jhunjhunwala, S., Raimondi, G., Thomson, A.W., & Little, S.R. (2009). Delivery of rapamycin to dendritic cells using degradable microparticles. J Control Release, 133(3), 191-197.Elsevier. doi: 10.1016/j.jconrel.2008.10.011.
Rothstein, S.N., Federspiel, W.J., & Little, S.R. (2009). A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices. Biomaterials, 30(8), 1657-1664.Elsevier. doi: 10.1016/j.biomaterials.2008.12.002.
Yadav, S., van Vlerken, L.E., Little, S.R., & Amiji, M.M. (2009). Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells. Cancer Chemother Pharmacol, 63(4), 711-722.Springer Nature. doi: 10.1007/s00280-008-0790-y.
Brito, L., Little, S., Langer, R., & Amiji, M. (2008). Poly(beta-amino ester) and cationic phospholipid-based lipopolyplexes for gene delivery and transfection in human aortic endothelial and smooth muscle cells. Biomacromolecules, 9(4), 1179-1187.American Chemical Society (ACS). doi: 10.1021/bm7011373.
Little, S.R., & Kohane, D.S. (2008). Polymers for intracellular delivery of nucleic acids. JOURNAL OF MATERIALS CHEMISTRY, 18(8), 832-841.Royal Society of Chemistry (RSC). doi: 10.1039/b712930k.
Raimondi, G., Jhunjhunwala, S., Thomson, A.W., & Little, S.R. (2008). Targeted delivery of rapamycin to dendritic cells using biodegradable microparticles is highly effective in suppressing their maturation and function. AMERICAN JOURNAL OF TRANSPLANTATION, 8(423), 423.
Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the rational design of controlled release therapeutics. AIChE Annual Meeting, Conference Proceedings.Carnegie Mellon University, Pittsburgh, Pennsylvania.
Rothstein, S.N., Federspiel, W.J., & Little, S.R. (2008). A simple model framework for the prediction of controlled release from bulk eroding polymer matrices. JOURNAL OF MATERIALS CHEMISTRY, 18(16), 1873-1880.Royal Society of Chemistry (RSC). doi: 10.1039/b718277e.
van Vlerken, L.E., Duan, Z., Little, S.R., Seiden, M.V., & Amiji, M.M. (2008). Biodistribution and pharmacokinetic analysis of Paclitaxel and ceramide administered in multifunctional polymer-blend nanoparticles in drug resistant breast cancer model. Mol Pharm, 5(4), 516-526.American Chemical Society (ACS). doi: 10.1021/mp800030k.
Choleris, E., Little, S.R., Mong, J.A., Puram, S.V., Langer, R., & Pfaff, D.W. (2007). Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice. Proc Natl Acad Sci U S A, 104(11), 4670-4675.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0700670104.
Devalapally, H., Shenoy, D., Little, S., Langer, R., & Amiji, M. (2007). Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model. Cancer Chemother Pharmacol, 59(4), 477-484.Springer Nature. doi: 10.1007/s00280-006-0287-5.
Zugates, G.T., Anderson, D.G., Little, S.R., Lawhorn, I.E.B., & Langer, R. (2006). Synthesis of poly(beta-amino ester)s with thiol-reactive side chains for DNA delivery. J Am Chem Soc, 128(39), 12726-12734.American Chemical Society (ACS). doi: 10.1021/ja061570n.
Little, S.R., & Langer, R. (2005). Nonviral delivery of cancer genetic vaccines. Adv Biochem Eng Biotechnol, 99, 93-118.Springer Nature. doi: 10.1007/10_004.
Little, S.R., Lynn, D.M., Puram, S.V., & Langer, R. (2005). Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery. J Control Release, 107(3), 449-462.Elsevier. doi: 10.1016/j.jconrel.2005.04.022.
Pfeifer, B.A., Burdick, J.A., Little, S.R., & Langer, R. (2005). Poly(ester-anhydride):poly(beta-amino ester) micro- and nanospheres: DNA encapsulation and cellular transfection. Int J Pharm, 304(1-2), 210-219.Elsevier. doi: 10.1016/j.ijpharm.2005.08.001.
Shenoy, D., Little, S., Langer, R., & Amiji, M. (2005). Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 2. In vivo distribution and tumor localization studies. Pharm Res, 22(12), 2107-2114.Springer Nature. doi: 10.1007/s11095-005-8343-0.
Shenoy, D., Little, S., Langer, R., & Amiji, M. (2005). Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations. Mol Pharm, 2(5), 357-366.American Chemical Society (ACS). doi: 10.1021/mp0500420.
Wood, K.C., Little, S.R., Langer, R., & Hammond, P.T. (2005). A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery. Angew Chem Int Ed Engl, 44(41), 6704-6708.Wiley. doi: 10.1002/anie.200502152.
Zugates, G.T., Little, S.R., Anderson, D.G., & Langer, R. (2005). Poly(β-amino ester)s for DNA delivery. ISRAEL JOURNAL OF CHEMISTRY, 45(4), 477-485.Wiley. doi: 10.1560/7C67-5X19-PEJ8-PXUN.
Haining, W.N., Anderson, D.G., Little, S.R., Cardoso, A.A., Alves, P., Kosmatopoulos, K., Nadler, L.M., Langer, R., Kohane, D.S., & Von Bergwelt-Baildon, M.S. (2004). Erratum: pH-triggered microparticles for peptide vaccination (Journal of Immunology (2004) 173 (2578-2585)). Journal of Immunology, 173(10), 6490.
Haining, W.N., Anderson, D.G., Little, S.R., von Bergwelt-Baildon, M.S., Cardoso, A.A., Alves, P., Kosmatopoulos, K., Nadler, L.M., Langer, R., & Kohane, D.S. (2004). pH-triggered microparticles for peptide vaccination. J Immunol, 173(4), 2578-2585.Oxford University Press (OUP). doi: 10.4049/jimmunol.173.4.2578.
Little, S.R., Lynn, D.M., Ge, Q., Anderson, D.G., Puram, S.V., Chen, J., Eisen, H.N., & Langer, R. (2004). Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci U S A, 101(26), 9534-9539.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0403549101.
Little, S.R., Lynn, D.M., Ge, Q., Anderson, D.G., Puram, S.V., Chen, J.Z., Eisen, H.N., & Langer, R. (2004). Poly-β amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(26), 9534-9539. doi: 10.1073/pnas.0403549101.
Balmert, S.C., Carey, C.D., Erdos, G., Korkmaz, E., Little, S.R., & Falo, L.D. (2020). Engineering the skin with microneedle arrays to induce immune tolerance. In JOURNAL OF INVESTIGATIVE DERMATOLOGY, 140(7), (p. S11).
Fisher, J.D., Zhang, W., Balmert, S.C., Aral, A.M., Kulahci, Y., Acharya, A.P., Li, J., Turnquist, H.R., Thomson, A.W., Solari, M.G., Gorantla, V.S., & Little, S.R. (2020). Recruitment of Regulatory T Cells Promotes Donor-Specific Tolerance in Vascularized Composite Allotransplantation. In AMERICAN JOURNAL OF TRANSPLANTATION, 20, (p. 536).
Balmert, S.C., Carey, C.D., Erdos, G., Little, S.R., & Falo, L.D. (2019). Microneedle arrays engineer the skin microenvironment to promote allergen tolerance. In JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(5), (p. S11).
Fedorchak, M.V., Kowalski, R.P., Romanowski, E.G., Schuman, J.S., & Little, S.R. (2016). Development of a semi-permanent, controlled release antibiotic eye drop. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12).
Biguetti, C.C., Vieira, A.E., Colavite, P., Cavalla, F., Francisconi, C., Trombone, A.F., Sfeir, C., Little, S.R., & Garlet, G.P. (2015). Impact of CCR2-Mediated Immunomodulation in the Outcome Bone Repair Process. In TISSUE ENGINEERING PART A, 21, (pp. S42-S43).
Gottardi, R., Bianconi, P.A., Manner, P.A., Alexander, P.G., Little, S.R., & Tuan, R.S. (2015). Prevention of Cartilage Calcification by Controlled Release of Dorsomorphin. Penn Orthopedics Cartilage Repair Symposium.Philadelphia, PA.
Bodnar, C.A., Beckman, E.J., McCarthy, J.J., & Little, S.R. (2014). A vision for the first product innovation sequence for chemical engineers. In ASEE Annual Conference and Exposition, Conference Proceedings.
Li, J., & Meyer, T.Y. (2013). Engineering hydrolysis behavior of poly(lactic-co-glycolic acid) through precise control of monomer sequence. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 246, (pp. 271-286).American Chemical Society (ACS). doi: 10.1021/bk-2014-1170.ch018.
Little, S.R., Glowacki, A., Jhunjhunwala, S., Yoshizawa, S., Garlet, G.P., & Sfeir, C. (2012). Rationally designed controlled release systems for periodontal disease that promote immunological homeostasis. Symposium on Polymers at the Interface of Biology.Philadelphia, PA.
Raimondi, G., Jhunjhunwala, S., Nichols, E., Thomson, A., & Little, S. (2012). All-trans retinoic acid and rapamycin synergize with transforming growth factor-B to induce regulatory T cells but confer distinct in vivo migratory capacities. Joint Annual Meeting of the International Cytokines Society and International Society for Interferon and Cytokine Research.Geneva, Switzerland. doi: 10.1016/j.cyto.2012.06.259.
Raimondi, G., Jhunjhunwala, S., Grahammer, J., Qi, M., Hall, S., Thorne, S.H., Thomson, A.W., Brandacher, G., & Little, S.R. (2011). Biomimetic Controlled Release of CCL22 for In Vivo Recruitment of Regulatory T Cells and Prolongation of Allograft Survival. American Transplant Congress.Philadelphia, PA.
Jhunjhunwala, S., Raimondi, G., Hall, S., Thorne, S., Thomson, A., & Little, S. (2010). Bio-inspired controlled release for regulatory T cell recruitment in vivo. The American Association of Immunologist, Immunology 2010.Baltimore, MD.
Jhunjhunwala, S., Raimondi, G., Thomson, A.W., & Little, S.R. (2009). Delivery of rapamycin to dendritic cells using degradable microparticles. Experimental Biology 2008.San Diego, CA. doi: 10.1016/j.jconrel.2008.10.011.
Little, S. (2009). Polymeric microcapsulates as a platform technology for biomimetic drug delivery. Duquesne University.Pittsburgh, PA.
Brito, L., Chandrasekhar, S., Little, S., & Amiji, M. (2008). Gene delivery and transfection studies with lipopolyplexes in human endothelial and smooth muscle cells. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, 2, (pp. 365-368).
Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Controlled Release Therapeutics. AIChE 2008 Annual Meeting.Philadelphia, PA.
Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the rational design of biodegradable controlled release vehicles. AIChE 2008 Annual Meeting.Philadelphia, PA.
Rothstein, S.N., Federspiel, W., & Little, S. (2008). A unified mathematical model for predicting controlled release from surface and bulk eroding matrices without regression. Poster session presented at the meeting of AIChE 2008 Annual Meeting.Philadelphia, PA.
Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Controlled Release Therapeutics. Biotechnology and Bioengineering Research Symposium. Biomedical Engineering Graduate Society Symposium, Carnegie Mellon University.Pittsburgh, PA.
Tengood, J., Wagner, W., Gerlach, J., Russell, A., & Little, S.R. (2008). Dissolvable hollow fibers for delivery in wound healing. In 8th World Biomaterials Congress 2008, 1, (p. 310).