headshot

Samira Kiani

Associate Professor
Bioengineering Department

overview

We are interested in building and examine genetic circuits that can control the CRISPR gene editing and epigenome editing tools with focus on application for immunotherapy, liver diseases and pain management. Please visit www.kianilab.com We also are actively involved in developing programs to engage public in conversations about science and technology by employing the power of fimmaking. Please visit www.tomorrow.life

about

Delgado, E., & Kiani, S. (2020). A CRISPR Odyssey into Cancer Immunotherapy. CRISPR JOURNAL, 3(2), 73-75.Mary Ann Liebert Inc. doi: 10.1089/crispr.2020.29090.ede.

Ferdosi, S.R., Ewaisha, R., Moghadam, F., Krishna, S., Park, J.G., Ebrahimkhani, M.R., Kiani, S., & Anderson, K.S. (2019). Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes. Nat Commun, 10(1), 1842.Springer Science and Business Media LLC. doi: 10.1038/s41467-019-09693-x.

Pineda, M., Lear, A., Collins, J.P., & Kiani, S. (2019). Safe CRISPR: Challenges and Possible Solutions. Trends in Biotechnology, 37(4), 389-401.Elsevier BV. doi: 10.1016/j.tibtech.2018.09.010.

Yeo, N.C., Chavez, A., Lance-Byrne, A., Chan, Y., Menn, D., Milanova, D., Kuo, C.C., Guo, X., Sharma, S., Tung, A., Cecchi, R.J., Tuttle, M., Pradhan, S., Lim, E.T., Davidsohn, N., Ebrahimkhani, M.R., Collins, J.J., Lewis, N.E., Kiani, S., & Church, G.M. (2018). An enhanced CRISPR repressor for targeted mammalian gene regulation. Nat Methods, 15(8), 611-616.Springer Science and Business Media LLC. doi: 10.1038/s41592-018-0048-5.

Kiani, S., Chavez, A., Tuttle, M., Hall, R.N., Chari, R., Ter-Ovanesyan, D., Qian, J., Pruitt, B.W., Beal, J., Vora, S., Buchthal, J., Kowal, E.J.K., Ebrahimkhani, M.R., Collins, J.J., Weiss, R., & Church, G. (2015). Cas9 gRNA engineering for genome editing, activation and repression. Nat Methods, 12(11), 1051-1054.Springer Science and Business Media LLC. doi: 10.1038/nmeth.3580.