headshot

Ioannis Zervantonakis

Assistant Professor
Lab website Google scholar Bioengineering Department

overview

We employ a quantitative approach that integrates microfluidics, systems biology modeling, and in vivo experiments to investigate the role of the tumor microenvironment on breast and ovarian cancer growth, metastasis and drug resistance.

about

(2020 - 2021) Hillman Early-career Fellow for Innovative Cancer Research.

(2017 - 2022) NIH Pathway to Independence Award (K99/R00).

PhD, Massachusetts Institute of Technology, 2007 - 2013

MSc, Technical University Munich, 2003 - 2005

BSc/MSc, National Technical University of Athens, 2001 - 2006

Hamalian, S., Guth, R., Runa, F., Sanchez, F., Vickers, E., Agajanian, M., Molnar, J., Nguyen, T., Gamez, J., Humphries, J.D., Nayak, A., Humphries, M.J., Tchou, J., Zervantonakis, I.K., & Kelber, J.A. (2021). A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling markers. ONCOGENE, 40(33), 5224-5235.Springer Science and Business Media LLC. doi: 10.1038/s41388-021-01906-2.

Correa, S., Boehnke, N., Barberio, A.E., Deiss-Yehiely, E., Shi, A., Oberlton, B., Smith, S.G., Zervantonakis, I., Dreaden, E.C., & Hammond, P.T. (2020). Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry. ACS NANO, 14(2), 2224-2237.American Chemical Society (ACS). doi: 10.1021/acsnano.9b09213.

Nyman, E., Stein, R.R., Jing, X., Wang, W., Marks, B., Zervantonakis, I.K., Korkut, A., Gauthier, N.P., & Sander, C. (2020). Perturbation biology links temporal protein changes to drug responses in a melanoma cell line. PLOS COMPUTATIONAL BIOLOGY, 16(7), e1007909.Public Library of Science (PLoS). doi: 10.1371/journal.pcbi.1007909.

Sarkizova, S., Klaeger, S., Le, P.M., Li, L.W., Oliveira, G., Keshishian, H., Hartigan, C.R., Zhang, W., Braun, D.A., Ligon, K.L., Bachireddy, P., Zervantonakis, I.K., Rosenbluth, J.M., Ouspenskaia, T., Law, T., Justesen, S., Stevens, J., Lane, W.J., Eisenhaure, T., Lan Zhang, G., Clauser, K.R., Hacohen, N., Carr, S.A., Wu, C.J., & Keskin, D.B. (2020). A large peptidome dataset improves HLA class I epitope prediction across most of the human population. NATURE BIOTECHNOLOGY, 38(2), 199-+.Springer Science and Business Media LLC. doi: 10.1038/s41587-019-0322-9.

Zervantonakis, I. (2020). Improving cancer combination therapy by timing drug administration. Science Translational Medicine, 12(539), eabb5671.American Association for the Advancement of Science (AAAS). doi: 10.1126/scitranslmed.abb5671.

Zervantonakis, I. (2020). Cancer-immune topology influences lung cancer evolution. Science Translational Medicine, 12(547), eabc8944.American Association for the Advancement of Science (AAAS). doi: 10.1126/scitranslmed.abc8944.

Zervantonakis, I. (2020). Not all fibroblasts are equal in cancer. Science Translational Medicine, 12(555), eabd4769.American Association for the Advancement of Science (AAAS). doi: 10.1126/scitranslmed.abd4769.

Zervantonakis, I. (2020). Uncovering metabolic states in cytotoxic T cells, one cell at a time. Science Translational Medicine, 12(563), eabe6027.American Association for the Advancement of Science (AAAS). doi: 10.1126/scitranslmed.abe6027.

Zervantonakis, I.K., Poskus, M.D., Scott, A.L., Selfors, L.M., Lin, J.R., Dillon, D.A., Pathania, S., Sorger, P.K., Mills, G.B., & Brugge, J.S. (2020). Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(28), 16500-16508.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.2000648117.

Zhao, W., Li, J., Chen, M.J.M., Luo, Y., Ju, Z., Nesser, N.K., Johnson-Camacho, K., Boniface, C.T., Lawrence, Y., Pande, N.T., Davies, M.A., Herlyn, M., Muranen, T., Zervantonakis, I.K., von Euw, E., Schultz, A., Kumar, S.V., Korkut, A., Spellman, P.T., Akbani, R., Slamon, D.J., Gray, J.W., Brugge, J.S., Lu, Y., Mills, G.B., & Liang, H. (2020). Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines. CANCER CELL, 38(6), 829-+.Elsevier BV. doi: 10.1016/j.ccell.2020.10.008.

Iavarone, C., Zervantonakis, I.K., Selfors, L.M., Palakurthi, S., Liu, J.F., Drapkin, R., Matulonis, U.A., Hallbergs, D., Velculescu, V.E., Leverson, J.D., Sampath, D., Mills, G.B., & Brugge, J.S. (2019). Combined MEK and BCL-2/X-L Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness. MOLECULAR CANCER THERAPEUTICS, 18(3), 642-655.American Association for Cancer Research (AACR). doi: 10.1158/1535-7163.MCT-18-0413.

Stover, E.H., Baco, M.B., Cohen, O., Li, Y.Y., Christie, E.L., Bagul, M., Goodale, A., Lee, Y., Pantel, S., Rees, M.G., Wei, G., Presser, A.G., Gelbard, M.K., Zhang, W., Zervantonakis, I.K., Bhola, P.D., Ryan, J., Guerriero, J.L., Montero, J., Liang, F.J., Cherniack, A.D., Piccioni, F., Matulonis, U.A., Bowtell, D.D.L., Sarosiek, K.A., Letai, A., Garraway, L.A., Johannessen, C.M., & Meyerson, M. (2019). Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer. MOLECULAR CANCER RESEARCH, 17(11), 2281-2293.American Association for Cancer Research (AACR). doi: 10.1158/1541-7786.MCR-18-1243.

Najafov, A., Zervantonakis, I.K., Mookhtiar, A.K., Greninger, P., March, R.J., Egan, R.K., Luu, H.S., Stover, D.G., Matulonis, U.A., Benes, C.H., & Yuan, J. (2018). BRAF and AXL oncogenes drive RIPK3 expression loss in cancer. PLOS BIOLOGY, 16(8), e2005756.Public Library of Science (PLoS). doi: 10.1371/journal.pbio.2005756.

Funamoto, K., Yoshino, D., Matsubara, K., Zervantonakis, I.K.Funamoto, K., Nakayama, M., Masamune, J., Kimura, Y., & Kamm, R.D. (2017). Endothelial monolayer permeability under controlled oxygen tension. INTEGRATIVE BIOLOGY, 9(6), 529-538.Oxford University Press (OUP). doi: 10.1039/c7ib00068e.

Liu, J.F., Palakurthi, S., Zeng, Q., Zhou, S., Ivanova, E., Huang, W., Zervantonakis, I.K., Selfors, L.M., Shen, Y., Pritchard, C.C., Zheng, M., Adleff, V., Papp, E., Piao, H., Novak, M., Fotheringham, S., Wulf, G.M., English, J., Kirschmeier, P.T., Velculescu, V.E., Paweletz, C., Mills, G.B., Livingston, D.M., Brugge, J.S., Matulonis, U.A., & Drapkin, R. (2017). Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics. CLINICAL CANCER RESEARCH, 23(5), 1263-1273.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-16-1237.

Zervantonakis, I.K., Iavarone, C., Chen, H.Y., Selfors, L.M., Palakurthi, S., Liu, J.F., Drapkin, R., Matulonis, U., Leverson, J.D., Sampath, D., Mills, G.B., & Brugge, J.S. (2017). Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response. NATURE COMMUNICATIONS, 8(1), 365.Springer Science and Business Media LLC. doi: 10.1038/s41467-017-00263-7.

Gallegos, L.L., Ng, M.R., Sowa, M.E., Selfors, L.M., White, A., Zervantonakis, I.K., Singh, P., Dhakal, S., Harper, J.W., & Brugge, J.S. (2016). A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for beta-catenin. SCIENTIFIC REPORTS, 6(1), 27114.Springer Science and Business Media LLC. doi: 10.1038/srep27114.

Iwanicki, M.P., Chen, H.Y., Iavarone, C., Zervantonakis, I.K., Muranen, T., Novak, M., Ince, T.A., Drapkin, R., & Brugge, J.S. (2016). Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition. JCI INSIGHT, 1(10).American Society for Clinical Investigation. doi: 10.1172/jci.insight.86829.

Kobus, T., Zervantonakis, I.K., Zhang, Y., & McDannold, N.J. (2016). Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption. JOURNAL OF CONTROLLED RELEASE, 238, 281-288.Elsevier BV. doi: 10.1016/j.jconrel.2016.08.001.

Spiegel, A., Brooks, M.W., Houshyar, S., Reinhardt, F., Ardolino, M., Fessler, E., Chen, M.B., Krall, J.A., DeCock, J., Zervantonakis, I.K., Iannello, A., Iwamoto, Y., Cortez-Retamozo, V., Kamm, R.D., Pittet, M.J., Raulet, D.H., & Weinberg, R.A. (2016). Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells. CANCER DISCOVERY, 6(6), 630-649.American Association for Cancer Research (AACR). doi: 10.1158/2159-8290.CD-15-1157.

Zervantonakis, I.K., & Arvanitis, C.D. (2016). Controlled Drug Release and Chemotherapy Response in a Novel Acoustofluidic 3D Tumor Platform. SMALL, 12(19), 2616-2626.Wiley. doi: 10.1002/smll.201503342.

Kandela, I., Zervantonakis, I., & Biol, R.P.C. (2015). Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data. ELIFE, 4(MAY), e06847.eLife Sciences Publications, Ltd. doi: 10.7554/eLife.06847.

Pavesi, A., Adriani, G., Rasponi, M., Zervantonakis, I.K., Fiore, G.B., & Kamm, R.D. (2015). Controlled electromechanical cell stimulation on-a-chip. SCIENTIFIC REPORTS, 5(1), 11800.Springer Science and Business Media LLC. doi: 10.1038/srep11800.

Schuessler, T.K., Chan, X.Y., Chen, H.J., Ji, K., Park, K.M., Roshan-Ghias, A., Sethi, P., Thakur, A., Tian, X., Villasante, A., Zervantonakis, I.K., Moore, N.M., Nagahara, L.A., & Kuhn, N.Z. (2014). Biomimetic Tissue-Engineered Systems for Advancing Cancer Research: NCI Strategic Workshop Report. CANCER RESEARCH, 74(19), 5359-5363.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-14-1706.

Srinivasan, P., Zervantonakis, I.K., & Kothapalli, C.R. (2014). Synergistic Effects of 3D ECM and Chemogradients on Neurite Outgrowth and Guidance: A Simple Modeling and Microfluidic Framework. PLOS ONE, 9(6), e99640.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0099640.

Aref, A.R., Huang, R.Y.J., Yu, W., Chua, K.N., Sun, W., Tu, T.Y., Bai, J., Sim, W.J., Zervantonakis, I.K., Thiery, J.P., & Kamm, R.D. (2013). Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. INTEGRATIVE BIOLOGY, 5(2), 381-389.Oxford University Press (OUP). doi: 10.1039/c2ib20209c.

Jeon, J.S., Zervantonakis, I.K., Chung, S., Kamm, R.D., & Charest, J.L. (2013). In Vitro Model of Tumor Cell Extravasation. PLOS ONE, 8(2), e56910.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0056910.

Polacheck, W.J., Zervantonakis, I.K., & Kamm, R.D. (2013). Tumor cell migration in complex microenvironments. CELLULAR AND MOLECULAR LIFE SCIENCES, 70(8), 1335-1356.Springer Science and Business Media LLC. doi: 10.1007/s00018-012-1115-1.

Chan, J.M., Zervantonakis, I.K., Rimchala, T., Polacheck, W.J., Whisler, J., & Kamm, R.D. (2012). Engineering of In Vitro 3D Capillary Beds by Self-Directed Angiogenic Sprouting. PLOS ONE, 7(12), e50582.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0050582.

Farahat, W.A., Wood, L.B., Zervantonakis, I.K., Schor, A., Ong, S., Neal, D., Kamm, R.D., & Asada, H.H. (2012). Ensemble Analysis of Angiogenic Growth in Three-Dimensional Microfluidic Cell Cultures. PLOS ONE, 7(5), e37333.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0037333.

Funamoto, K., Zervantonakis, I.K., Liu, Y., Ochs, C.J., Kim, C., & Kamm, R.D. (2012). A novel microfluidic platform for high-resolution imaging of a three-dimensional cell culture under a controlled hypoxic environment. LAB ON A CHIP, 12(22), 4855-4863.Royal Society of Chemistry (RSC). doi: 10.1039/c2lc40306d.

Shin, Y., Han, S., Jeon, J.S., Yamamoto, K., Zervantonakis, I.K., Sudo, R., Kamm, R.D., & Chung, S. (2012). Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels. NATURE PROTOCOLS, 7(7), 1247-1259.Springer Science and Business Media LLC. doi: 10.1038/nprot.2012.051.

Zervantonakis, I.K., Hughes-Alford, S.K., Charest, J.L., Condeelis, J.S., Gertler, F.B., & Kamm, R.D. (2012). Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(34), 13515-13520.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1210182109.

Kothapalli, C.R., van Veen, E., de Valence, S., Chung, S., Zervantonakis, I.K., Gertler, F.B., & Kamm, R.D. (2011). A high-throughput microfluidic assay to study neurite response to growth factor gradients. LAB ON A CHIP, 11(3), 497-507.Royal Society of Chemistry (RSC). doi: 10.1039/c0lc00240b.

Luo, Y., Zervantonakis, I.K., Oh, S.B., Kamm, R.D., & Barbastathis, G. (2011). Spectrally resolved multidepth fluorescence imaging. JOURNAL OF BIOMEDICAL OPTICS, 16(9), 096015.SPIE-Intl Soc Optical Eng. doi: 10.1117/1.3626211.

Zervantonakis, I.K., Kothapalli, C.R., Chung, S., Sudo, R., & Kamm, R.D. (2011). Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments. BIOMICROFLUIDICS, 5(1), 13406.AIP Publishing. doi: 10.1063/1.3553237.

Chung, S., Sudo, R., Zervantonakis, I.K., Rimchala, T., & Kamm, R.D. (2009). Microfluidics: surface-treatment-induced three-dimensional capillary morphogenesis in a microfluidic platform (adv. Mater. 47/2009). Adv Mater, 21(47), n/a.Wiley. doi: 10.1002/adma.200990175.

Chung, S., Sudo, R., Zervantonakis, I.K., Rimchala, T., & Kamm, R.D. (2009). Surface-Treatment-Induced Three-Dimensional Capillary Morphogenesis in a Microfluidic Platform. ADVANCED MATERIALS, 21(47), 4863-+.Wiley. doi: 10.1002/adma.200901727.

Sudo, R., Chung, S., Zervantonakis, I.K., Vickerman, V., Toshimitsu, Y., Griffith, L.G., & Kamm, R.D. (2009). Transport-mediated angiogenesis in 3D epithelial coculture. FASEB JOURNAL, 23(7), 2155-2164.Wiley. doi: 10.1096/fj.08-122820.

Das, S.K., Chung, S., Zervantonakis, I., Atnafu, J., & Kamm, R.D. (2008). A microfluidic platform for studying the effects of small temperature gradients in an incubator environment. BIOMICROFLUIDICS, 2(3), 34106.AIP Publishing. doi: 10.1063/1.2988313.

Zervantonakis, I.K., Fung-Kee-Fung, S.D., Lee, W.N., & Konofagou, E.E. (2007). A novel, view-independent method for strain mapping in myocardial elastography: eliminating angle and centroid dependence. PHYSICS IN MEDICINE AND BIOLOGY, 52(14), 4063-4080.IOP Publishing. doi: 10.1088/0031-9155/52/14/004.

Hamalian, S., Güth, R., Runa, F., Molnar, J., Vickers, E., Agajanian, M., Humphries, J., Humphries, M.J., Tchou, J., Zervantonakis, I.K., & Kelber, J.A. A SNAI2-PEAK1 stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting a cytokine expression profile that converges on PI3K/Akt signaling. Cold Spring Harbor Laboratory. doi: 10.1101/2020.05.15.098772.

Kalli, M., Li, R., Mills, G.B., Stylianopoulos, T., & Zervantonakis, I.K. Mechanical stress in pancreatic cancer: Signaling pathway adaptation activates cytoskeletal remodeling and enhances cell migration. Cold Spring Harbor Laboratory. doi: 10.1101/2021.06.11.448065.

Rosenbluth, J.M., Zervantonakis, I., Boedicker, M., Wagle, N., Dillon, D., Nakhlis, F., Brugge, J.S., & Overmoyer, B. (2019). Patient-derived organoid models of inflammatory breast cancer. In CANCER RESEARCH, 79(4).American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS18-P5-17-01.

Stover, E.H., Baco, M.B., Cohen, O., Li, Y., Christie, E., Bagul, M., Goodale, A., Lee, Y., Pantel, S., Rees, M., Wei, G., Presser, A., Zervantonakis, I., Bhola, P., Ryan, J., Guerriero, J., Liang, F., Cherniack, A., Piccioni, F., Matulonis, U.A., Bowtell, D.D.L., Letai, A., Sarosiek, K., Garraway, L., Johannessen, C.M., & Meyerson, M. (2019). POOLED GENOMIC SCREENS IDENTIFY ANTI-APOPTOTIC GENES AS MEDIATORS OF CHEMOTHERAPY RESISTANCE IN OVARIAN CANCER. In CLINICAL CANCER RESEARCH, 25(22), (p. 74).

Hamalian, S., Guth, R., Zervantonakis, I., Duell, E., Lin, J.R., Shisgal, P., Molnar, J., Geller, C., Agajanian, M., Tchou, J., Sorger, P.K., Brugge, J.S., & Kelber, J.A. (2018). Mesenchymal stromal cells expressing a PEAK1/Cripto axis sustain pro-survival NF-kappa B signaling in adjacent tumor cells to promote disease progression and therapy resistance. In CANCER RESEARCH, 78(13).American Association for Cancer Research. doi: 10.1158/1538-7445.AM2018-2140.

Iavarone, C., Zervantonakis, I.K., Selfors, L.M., Palakurthi, S.S., Liu, J.F., Drapkin, R., Mills, G.B., Leverson, J.D., Sampath, D., Matulonis, U.A., & Brugge, J.S. (2018). Combined MEK and BCL-2/XL inhibition as a potential drug combination for the treatment of high-grade serous ovarian cancer. In CLINICAL CANCER RESEARCH, 24(15), (pp. 31-+).

Iavarone, C., Zervantonakis, I., Selfors, L.M., Palakurthi, S., Liu, J.F., Matulonis, U.A., Drapkin, R.I., Mills, G.B., Leverson, J.D., Sampath, D., & Brugge, J.S. (2017). Combined MEK and BCL-2/X-L inhibition as a potential drug combination for the treatment of high-grade serous ovarian cancer. In CANCER RESEARCH, 77.American Association for Cancer Research. doi: 10.1158/1538-7445.AM2017-4033.

Zervantonakis, I.K., Iavarone, C., Chen, H.Y., Leverson, J., Sampath, D., Palakurthi, S., Drapkin, R., Liu, J.F., Matulonis, U., Mills, G., & Brugge, J.S. (2017). Systems analysis of signaling pathway adaptation to design effective PI3K-based combination therapies using ovarian cancer patient-derived xenografts. In CANCER RESEARCH, 77.American Association for Cancer Research. doi: 10.1158/1538-7445.EPSO16-PR01.

Iavarone, C., Zervantonakis, I., Chen, H.Y., Palakurthi, S.S., Liu, J.F., Matulonis, U., Drapkin, R., Mills, G., Leverson, J., Sampath, D., & Brugge, J. (2016). Design of effective combination therapies for high-grade serous ovarian cancer using patient -derived xenograft models. In CANCER RESEARCH, 76.American Association for Cancer Research. doi: 10.1158/1538-7445.AM2016-3843.

Iavarone, C., Zervantonakis, I., Chen, H.Y., Palakurthi, S.S., Liu, J.F., Matulonis, U.A., Drapkin, R.I., Mills, G.B., Leverson, J.D., Sampath, D., & Brugge, J.S. (2016). Design of effective combination therapies for high-grade serous ovarian cancer using patient-derived xenograft models. In CLINICAL CANCER RESEARCH, 22.American Association for Cancer Research. doi: 10.1158/1557-3265.OVCA15-B48.

Iwanicki, M.P., Chen, H.Y., Zervantonakis, I., Novak, M., Muranen, T., Ince, T.A., Drapkin, R., & Brugge, J.S. (2016). Mutant p53 drives early events in fallopian tube tumorigenesis through mesenchyme-associated autocrine production of matrix that supports survival and mesothelial intercalation. In CLINICAL CANCER RESEARCH, 22.American Association for Cancer Research. doi: 10.1158/1557-3265.OVCA15-PR12.

Zervantonakis, I., Chen, H.Y., Muranen, T., Liu, J., Drapkin, R., Matulonis, U., & Brugge, J. (2015). Adaptive resistance of patient-derived ovarian cancer cells to PI3K/mTOR inhibition. In CLINICAL CANCER RESEARCH, 21.American Association for Cancer Research. doi: 10.1158/1557-3265.PMS14-PR01.

Gallegos, L.L., Ng, M.R., Sowa, M.E., White, A., Selfors, L., Zervantonakis, I., Dhakal, S., Singh, P., Harper, J.W., & Brugge, J.S. (2014). A functional proteomic study identifies multiple novel regulators of epithelial cell-cell adhesion. In MOLECULAR BIOLOGY OF THE CELL, 25.

Srinivasan, P., Zervantonakis, I.K., & Kothapalli, C.R. (2014). Theoretical and Experimental Framework of Neurite Response to Chemical Gradients in 3D Matrices. In BIOPHYSICAL JOURNAL, 106(2), (p. 572A).Elsevier BV. doi: 10.1016/j.bpj.2013.11.3172.

Iwanicki, M.P., Novak, M., Zervantonakis, I.K., Ince, T.A., Drapkin, R., & Brugge, J.S. (2013). Targeting mutant p53 and cell-cell adhesion in ovarian cancer. In CLINICAL CANCER RESEARCH, 19.American Association for Cancer Research. doi: 10.1158/1078-0432.OVCA13-A7.

Luo, Y., Zervantonakis, I., Oh, S.B., Kamm, R., & Barbastathis, G. (2011). Spectrum resolved fluorescence imaging in multi-focal volume holographic microscopy. In Design and Quality for Biomedical Technologies IV, 7891.SPIE. doi: 10.1117/12.874570.

Chung, S., Sudo, R., Vickerman, V., Zervantonakis, I.K., & Kamm, R.D. (2010). Microfluidic Platforms for Studies of Angiogenesis, Cell Migration, and Cell-Cell Interactions. In ANNALS OF BIOMEDICAL ENGINEERING, 38(3), (pp. 1164-1177).Springer Science and Business Media LLC.United States. doi: 10.1007/s10439-010-9899-3.

Zervantonakis, I., Sudo, R., Rimchala, T., Polacheck, W., Chung, S., & Kamm, R. (2009). A physiological relevant 3D in vitro model of cancer cell migration and interactions with endothelium. In CANCER RESEARCH, 69.

Chung, S., Sudo, R., Zervantonakis, I., Rimchala, T., Mack, P.J., Wan, C.R., Vickerman, V., & Kamm, R.D. (2008). Microfluidic platform to study three dimensional cell migration & capillary morphogenesis. In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference, (pp. 24-26).

Research interests

Cell and Drug transport phenomena...
Mathematical modeling of cell-cell...
Microfluidics
Systems Biology of Cell-cell...