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Ian Sigal

Associate Professor
Bioengineering Department

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Gogola, A., Jan, N.J., Brazile, B., Lam, P., Lathrop, K.L., Chan, K.C., & Sigal, I.A. (2018). Spatial Patterns and Age-Related Changes of the Collagen Crimp in the Human Cornea and Sclera. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(7), 2987-2998.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.17-23474.

Hua, Y., Voorhees, A.P., & Sigal, I.A. (2018). Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics. Invest Ophthalmol Vis Sci, 59(1), 154-165.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.17-22488.

Hua, Y., Voorhees, A.P., & Sigal, I.A. (2018). Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Bloinechanics. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(1), 154-165. doi: 10.1167/iovs.17-22488.

Jan, N.J., & Sigal, I.A. (2018). Collagen fiber recruitment: A microstructural basis for the nonlinear response of the posterior pole of the eye to increases in intraocular pressure. ACTA BIOMATERIALIA, 72, 295-305.Elsevier BV. doi: 10.1016/j.actbio.2018.03.026.

Jan, N.J., Brazile, B.L., Hu, D., Grube, G., Wallace, J., Gogola, A., & Sigal, I.A. (2018). Crimp around the globe; patterns of collagen crimp across the corneoscleral shell. EXPERIMENTAL EYE RESEARCH, 172, 159-170.Elsevier BV. doi: 10.1016/j.exer.2018.04.003.

Sibony, P.A., Wei, J., & Sigal, I.A. (2018). Gaze-Evoked Deformations in Optic Nerve Head Drusen Repetitive Shearing as a Potential Factor in the Visual and Vascular Complications. OPHTHALMOLOGY, 125(6), 929-937.Elsevier BV. doi: 10.1016/j.ophtha.2017.12.006.

Tran, H., Wallace, J., Zhu, Z., Lucy, K.A., Voorhees, A.P., Schmitt, S.E., Bilonick, R.A., Schuman, J.S., Smith, M.A., Wollstein, G., & Sigal, I.A. (2018). Seeing the Hidden Lamina: Effects of Exsanguination on the Optic Nerve Head. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(6), 2564-2575.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.17-23356.

Wang, B., Lucy, K.A., Schuman, J.S., Sigal, I.A., Bilonick, R.A., Lu, C., Liu, J., Grulkowski, I., Nadler, Z., Ishikawa, H., Kagemann, L., Fujimoto, J.G., & Wollstein, G. (2018). Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa. SCIENTIFIC REPORTS, 8(1), 7281.Springer Science and Business Media LLC. doi: 10.1038/s41598-018-25645-9.

Yang, B., Jan, N.J., Brazile, B., Voorhees, A., Lathrop, K.L., & Sigal, I.A. (2018). Polarized light microscopy for 3-dimensional mapping of collagen fiber architecture in ocular tissues. JOURNAL OF BIOPHOTONICS, 11(8), e201700356.Wiley. doi: 10.1002/jbio.201700356.

Jan, N.J., Gomez, C., Moed, S., Voorhees, A.P., Schuman, J.S., Bilonick, R.A., & Sigal, I.A. (2017). Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(9), 3378-3388. doi: 10.1167/iovs.17-21811.

Jan, N.J., Lathrop, K., & Sigal, I.A. (2017). Collagen Architecture of the Posterior Pole: High-Resolution Wide Field of View Visualization and Analysis Using Polarized Light Microscopy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(2), 735-744.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.16-20772.

Lucy, K.A., Wang, B., Schuman, J.S., Bilonick, R.A., Ling, Y., Kagemann, L., Sigal, I.A., Grulkowski, I., Liu, J.J., Fujimoto, J.G., Ishikawa, H., & Wollstein, G. (2017). Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(3), 1751-1757.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.16-20784.

Pant, A.D., Kagemann, L., Schuman, J.S., Sigal, I.A., & Amini, R. (2017). An imaged-based inverse finite element method to determine in-vivo mechanical properties of the human trabecular meshwork. J Model Ophthalmol, 1(3), 100-111.

Tran, H., Jan, N.J., Hu, D., Voorhees, A., Schuman, J.S., Smith, M.A., Wollstein, G., & Sigal, I.A. (2017). Formalin Fixation and Cryosectioning Cause Only Minimal Changes in Shape or Size of Ocular Tissues. SCIENTIFIC REPORTS, 7(1), 12065.Springer Science and Business Media LLC. doi: 10.1038/s41598-017-12006-1.

Voorhees, A.P., Ho, L.C., Jan, N.J., Tran, H., van der Merwe, Y., Chan, K., & Sigal, I.A. (2017). Whole-globe biomechanics using high-field MRI. EXPERIMENTAL EYE RESEARCH, 160, 85-95.Elsevier BV. doi: 10.1016/j.exer.2017.05.004.

Voorhees, A.P., Jan, N.J., & Sigal, I.A. (2017). Effects of collagen microstructure and material properties on the deformation of the neural tissues of the lamina cribrosa. ACTA BIOMATERIALIA, 58, 278-290.Elsevier BV. doi: 10.1016/j.actbio.2017.05.042.

Voorhees, A.P., Jan, N.J., Austin, M.E., Flanagan, J.G., Sivak, J.M., Bilonick, R.A., & Sigal, I.A. (2017). Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(12), 5336-5346.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.17-22015.

Wang, B., Lucy, K.A., Schuman, J.S., Ishikawa, H., Bilonick, R.A., Sigal, I.A., Kagemann, L., Lu, C., Fujimoto, J.G., & Wollstein, G. (2017). Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes. SCIENTIFIC REPORTS, 7(1), 9930.Springer Science and Business Media LLC. doi: 10.1038/s41598-017-10042-5.

Wang, B., Tran, H., Smith, M.A., Kostanyan, T., Schmitt, S.E., Bilonick, R.A., Jan, N.J., Kagemann, L., Tyler-Kabara, E.C., Ishikawa, H., Schuman, J.S., Sigal, I.A., & Wollstein, G. (2017). In-vivo effects of intraocular and intracranial pressures on the lamina cribrosa microstructure. PLOS ONE, 12(11), e0188302.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0188302.

Chung, C.W., Girard, M.J.A., Jan, N.J., & Sigal, I.A. (2016). Use and Misuse of Laplace's Law in Ophthalmology. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(1), 236-245.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.15-18053.

Fortune, B., Reynaud, J., Hardin, C., Wang, L., Sigal, I.A., & Burgoyne, C.F. (2016). Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(10), 4403-4411.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.16-20000.

Ho, L.C., Sigal, I.A., Jan, N.J., Yang, X., van der Merwe, Y., Yu, Y., Chau, Y., Leung, C.K., Conner, I.P., Jin, T., Wu, E.X., Kim, S.G., Wollstein, G., Schuman, J.S., & Chan, K.C. (2016). Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation. SCIENTIFIC REPORTS, 6(1), 32080.Springer Science and Business Media LLC. doi: 10.1038/srep32080.

Loewen, R.T., Brown, E.N., Roy, P., Schuman, J.S., Sigal, I.A., & Loewen, N.A. (2016). Regionally Discrete Aqueous Humor Outflow Quantification Using Fluorescein Canalograms. In Gonzalez, P. (Ed.). PLOS ONE, 11(3), e0151754.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0151754.

Sigal, I.A., Schuman, J.S., Ishikawa, H., Kagemann, L., & Wollstein, G. (2016). A Problem of Proportions in OCT-Based Morphometry and a Proposed Solution. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(2), 484-485.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.15-18570.

Sigal, I.A., Steele, J., Drexler, S., & Lathrop, K.L. (2016). Identifying the Palisades of Vogt in Human Ex Vivo Tissue. OCULAR SURFACE, 14(4), 435-439.Elsevier BV. doi: 10.1016/j.jtos.2016.07.003.

Squires, A., Chan, K.C., Ho, L.C., Sigal, I.A., Jan, N.J., & Tse, Z.T.H. (2016). MAPS - a Magic Angle Positioning System for Enhanced Imaging in High-Field Small-Bore MRI. J Med Robot Res, 1(1), 1640004.World Scientific Pub Co Pte Lt. doi: 10.1142/S2424905X16400043.

Voorhees, A.P., Grimm, J.L., Bilonick, R.A., Kagemann, L., Ishikawa, H., Schuman, J.S., Wollstein, G., & Sigal, I.A. (2016). What is a typical optic nerve head?. EXPERIMENTAL EYE RESEARCH, 149, 40-47.Elsevier BV. doi: 10.1016/j.exer.2016.06.012.

Wang, B., Lucy, K.A., Schuman, J.S., Sigal, I.A., Bilonick, R.A., Kagemann, L., Kostanyan, T., Lu, C., Liu, J., Grulkowski, I., Fujimoto, J.G., Ishikawa, H., & Wollstein, G. (2016). Decreased Lamina Cribrosa Beam Thickness and Pore Diameter Relative to Distance From the Central Retinal Vessel Trunk. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(7), 3088-3092.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.15-19010.

Bilonick, R.A., Ling, Y., Wollstein, G., Ishikawa, H., Kagemann, L., Sigal, I.A., Sandrian, M.G., & Schuman, J.S. (2015). Measuring Glaucoma Progression Using a Common Factor Model. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7).

Chen, C.L., Ishikawa, H., Wollstein, G., Bilonick, R.A., Sigal, I.A., Kagemann, L., & Schuman, J.S. (2015). Histogram Matching Extends Acceptable Signal Strength Range on Optical Coherence Tomography Images. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(6), 3810-3819.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.15-16502.

Girard, M.J.A., Dupps, W.J., Baskaran, M., Scarcelli, G., Yun, S.H., Quigley, H.A., Sigal, I.A., & Strouthidis, N.G. (2015). Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects. CURRENT EYE RESEARCH, 40(1), 1-18.Informa UK Limited. doi: 10.3109/02713683.2014.914543.

Ho, L.C., Wang, B., Conner, I.P., van der Merwe, Y., Bilonick, R.A., Kim, S.G., Wu, E.X., Sigal, I.A., Wollstein, G., Schuman, J.S., & Chan, K.C. (2015). In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(6), 3788-3800.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.14-15552.

Jan, N.J., Grimm, J.L., Tran, H., Lathrop, K.L., Wollstein, G., Bilonick, R.A., Ishikawa, H., Kagemann, L., Schuman, J.S., & Sigal, I.A. (2015). Polarization microscopy for characterizing fiber orientation of ocular tissues. BIOMEDICAL OPTICS EXPRESS, 6(12), 4705-4718.The Optical Society. doi: 10.1364/BOE.6.004705.

Rangarajan, A.A., Ishikawa, H., Wollstein, G., Kagemann, L., Sigal, I.A., Bilonick, R.A., Sandrian, M.G., & Schuman, J.S. (2015). Single Frame Virtual Averaging Improved Optical Coherence Tomography (OCT) Images Independent from Eye Movement Artifacts. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7).

Sigal, I.A., Jan, N.J., Moed, S., O'Malley, R., Tran, H., Bilonick, R.A., Ishikawa, H., Kagemann, L., Schuman, J.S., & Wollstein, G. (2015). A microstructural basis for nonlinear effects of IOP on the lamina cribrosa and sclera. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7).

Wang, B., Sigal, I.A., Smith, M.A., Kostanyan, T., Bilonick, R.A., Tran, H., Kagemann, L., Tyler-Kabara, E., Schuman, J.S., & Wollstein, G. (2015). In-vivo 3D Deformation of Lamina Cribrosa Microstructure in Response to Acute Changes in Intraocular and Cerebrospinal Fluid Pressures. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7).

Bernick, J., Wang, Y., Sigal, I.A., Alman, B.A., Whyne, C.M., & Nam, D. (2014). Parameters for lithium treatment are critical in its enhancement of fracture-healing in rodents. J Bone Joint Surg Am, 96(23), 1990-1998.Ovid Technologies (Wolters Kluwer Health). doi: 10.2106/JBJS.N.00057.

Ho, L.C., Sigal, I.A., Jan, N.J., Squires, A., Tse, Z., Wu, E.X., Kim, S.G., Schuman, J.S., & Chan, K.C. (2014). Magic Angle-Enhanced MRI of Fibrous Microstructures in Sclera and Cornea With and Without Intraocular Pressure Loading. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(9), 5662-5672.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.14-14561.

Kagemann, L., Nevins, J.E., Jan, N.J., Wollstein, G., Ishikawa, H., Kagemann, J., Sigal, I.A., Nadler, Z., Ling, Y., & Schuman, J.S. (2014). Characterisation of Schlemm's canal cross-sectional area. BRITISH JOURNAL OF OPHTHALMOLOGY, 98(Suppl 2), 10-14.BMJ. doi: 10.1136/bjophthalmol-2013-304629.

Kagemann, L., Wang, B., Wollstein, G., Ishikawa, H., Nevins, J.E., Nadler, Z., Sigal, I.A., Bilonick, R.A., & Schuman, J.S. (2014). IOP Elevation Reduces Schlemm's Canal Cross-Sectional Area. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(3), 1805-1809.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.13-13264.

Nadler, Z., Wang, B., Schuman, J.S., Ferguson, R.D., Patel, A., Hammer, D.X., Bilonick, R.A., Ishikawa, H., Kagemann, L., Sigal, I.A., & Wollstein, G. (2014). In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa With Adaptive Optics Spectral-Domain Optical Coherence Tomography. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(10), 6459-6466.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.14-15177.

Nadler, Z., Wang, B., Wollstein, G., Nevins, J.E., Ishikawa, H., Bilonick, R., Kagemann, L., Sigal, I.A., Ferguson, R.D., Patel, A., Hammer, D.X., & Schuman, J.S. (2014). Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography. BIOMEDICAL OPTICS EXPRESS, 5(4), 1114-1123.The Optical Society. doi: 10.1364/BOE.5.001114.

Sanfilippo, P.G., Grimm, J.L., Flanagan, J.G., Lathrop, K.L., & Sigal, I.A. (2014). Application of Elliptic Fourier analysis to describe the lamina cribrosa shape with age and intraocular pressure. EXPERIMENTAL EYE RESEARCH, 128, 1-7.Elsevier BV. doi: 10.1016/j.exer.2014.08.013.

Sigal, I.A., Grimm, J.L., Jan, N.J., Reid, K., Minckler, D.S., & Brown, D.J. (2014). Eye-Specific IOP-Induced Displacements and Deformations of Human Lamina Cribrosa. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(1), 1-15.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.13-12724.

Sigal, I.A., Grimm, J.L., Schuman, J.S., Kagemann, L., Ishikawa, H., & Wollstein, G. (2014). A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography. IEEE TRANSACTIONS ON MEDICAL IMAGING, 33(6), 1381-1389.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TMI.2014.2312133.

Sigal, I.A., Wang, B., Strouthidis, N.G., Akagi, T., & Girard, M.J.A. (2014). Recent advances in OCT imaging of the lamina cribrosa. BRITISH JOURNAL OF OPHTHALMOLOGY, 98(Suppl 2), 34-39.BMJ. doi: 10.1136/bjophthalmol-2013-304751.

Wang, B., Kagemann, L., Schuman, J.S., Ishikawa, H., Bilonick, R.A., Ling, Y., Sigal, I.A., Nadler, Z., Francis, A., Sandrian, M.G., & Wollstein, G. (2014). Gold Nanorods as a Contrast Agent for Doppler Optical Coherence Tomography. In Bhattacharya, S. (Ed.). PLOS ONE, 9(3), e90690.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0090690.

Wang, B., Nevins, J.E., Nadler, Z., Wollstein, G., Ishikawa, H., Bilonick, R.A., Kagemann, L., Sigal, I.A., Grulkowski, I., Liu, J.J., Kraus, M., Lu, C.D., Hornegger, J., Fujimoto, J.G., & Schuman, J.S. (2014). Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture. In Stieger, K. (Ed.). PLOS ONE, 9(4), e95526.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0095526.

Chen, C.L., Ishikawa, H., Ling, Y., Wollstein, G., Bilonick, R.A., Xu, J., Fujimoto, J.G., Sigal, I.A., Kagemann, L., & Schuman, J.S. (2013). Signal Normalization Reduces Systematic Measurement Differences Between Spectral-Domain Optical Coherence Tomography Devices. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(12), 7317-7322.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.13-12806.

Chen, C.L., Ishikawa, H., Wollstein, G., Ling, Y., Bilonick, R.A., Kagemann, L., Sigal, I.A., & Schuman, J.S. (2013). Individual A-Scan Signal Normalization Between Two Spectral Domain Optical Coherence Tomography Devices. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(5), 3463-3471.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.12-11484.

Ishikawa, H., Chen, C.L., Wollstein, G., Grimm, J.L., Ling, Y., Bilonick, R.A., Sigal, I.A., Kagemann, L., & Schuman, J.S. (2013). High Dynamic Range Imaging Concept-Based Signal Enhancement Method Reduced the Optical Coherence Tomography Measurement Variability. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(1), 836-841.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.12-10990.

Nadler, Z., Wang, B., Wollstein, G., Nevins, J.E., Ishikawa, H., Kagemann, L., Sigal, I.A., Ferguson, R.D., Hammer, D.X., Grulkowski, I., Liu, J.J., Kraus, M.F., Lu, C.D., Hornegger, J., Fujimoto, J.G., & Schuman, J.S. (2013). Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes. BIOMEDICAL OPTICS EXPRESS, 4(11), 2596-2608.The Optical Society. doi: 10.1364/BOE.4.002596.

Wang, B., Nevins, J.E., Nadler, Z., Wollstein, G., Ishikawa, H., Bilonick, R.A., Kagemann, L., Sigal, I.A., Grulkowski, I., Liu, J.J., Kraus, M., Lu, C.D., Hornegger, J., Fujimoto, J.G., & Schuman, J.S. (2013). In Vivo Lamina Cribrosa Micro-Architecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(13), 8270-8274.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.13-13109.

Francis, A.W., Kagemann, L., Wollstein, G., Ishikawa, H., Folz, S., Overby, D.R., Sigal, I.A., Wang, B., & Schuman, J.S. (2012). Morphometric Analysis of Aqueous Humor Outflow Structures with Spectral-Domain Optical Coherence Tomography. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53(9), 5198-5207.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.11-9229.

Grytz, R., Sigal, I.A., Ruberti, J.W., Meschke, G., & Downs, J.C. (2012). Lamina cribrosa thickening in early glaucoma predicted by a microstructure motivated growth and remodeling approach. MECHANICS OF MATERIALS, 44, 99-109.Elsevier BV. doi: 10.1016/j.mechmat.2011.07.004.

Kagemann, L., Wollstein, G., Ishikawa, H., Nadler, Z., Sigal, I.A., Folio, L.S., & Schuman, J.S. (2012). Visualization of the Conventional Outflow Pathway in the Living Human Eye. OPHTHALMOLOGY, 119(8), 1563-1568.Elsevier BV. doi: 10.1016/j.ophtha.2012.02.032.

Sigal, I.A., & Grimm, J.L. (2012). A Few Good Responses: Which Mechanical Effects of IOP on the ONH to Study?. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53(7), 4270-4278.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.11-8739.

Sigal, I.A., Bilonick, R.A., Kagemann, L., Wollstein, G., Ishikawa, H., Schuman, J.S., & Grimm, J.L. (2012). The Optic Nerve Head as a Robust Biomechanical System. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53(6), 2658-2667.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.11-9303.

Sigal, I.A., Flanagan, J.G., Lathrop, K.L., Tertinegg, I., & Bilonick, R. (2012). Human Lamina Cribrosa Insertion and Age. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53(11), 6870-6879.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.12-9890.

Kagemann, L., Wollstein, G., Ishikawa, H., Sigal, I.A., Folio, L.S., Xu, J., Gong, H., & Schuman, J.S. (2011). 3D visualization of aqueous humor outflow structures in-situ in humans. EXPERIMENTAL EYE RESEARCH, 93(3), 308-315.Elsevier BV. doi: 10.1016/j.exer.2011.03.019.

Sigal, I.A. (2011). An Applet to Estimate the IOP-Induced Stress and Strain within the Optic Nerve Head. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52(8), 5497-5506.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.10-7141.

Sigal, I.A., Yang, H., Roberts, M.D., Burgoyne, C.F., & Downs, J.C. (2011). IOP-induced lamina cribrosa displacement and scleral canal expansion: an analysis of factor interactions using parameterized eye-specific models. Invest Ophthalmol Vis Sci, 52(3), 1896-1907.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.10-5500.

Sigal, I.A., Yang, H., Roberts, M.D., Grimm, J.L., Burgoyne, C.F., Demirel, S., & Downs, J.C. (2011). IOP-Induced Lamina Cribrosa Deformation and Scleral Canal Expansion: Independent or Related?. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52(12), 9023-9032.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.11-8183.

Strouthidis, N.G., Fortune, B., Yang, H., Sigal, I.A., & Burgoyne, C.F. (2011). Effect of Acute Intraocular Pressure Elevation on the Monkey Optic Nerve Head as Detected by Spectral Domain Optical Coherence Tomography. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52(13), 9431-9437.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.11-7922.

Yang, H., Williams, G., Downs, J.C., Sigal, I.A., Roberts, M.D., Thompson, H., & Burgoyne, C.F. (2011). Posterior (Outward) Migration of the Lamina Cribrosa and Early Cupping in Monkey Experimental Glaucoma. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 52(10), 7109-7121.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/iovs.11-7448.

Sigal, I., Brazile, B., Yang, B., Jan, N.J., & Voorhees, A.P. (2018). Structured polarized light microscopy (SPLM) for mapping collagen fiber orientation of ocular tissues. In Emerging Digital Micromirror Device Based Systems and Applications X, 10546.SPIE. doi: 10.1117/12.2290133.

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