Howard Aizenstein

Thurston, R.C., Jakubowski, K.P., Wu, M., Aizenstein, H.J., Chang, Y., Derby, C.A., Koenen, K.C., Barinas-Mitchell, E., & Maki, P.M. (2022). Sexual assault and white matter hyperintensities among midlife women. Brain Imaging Behav, 16(2), 773-780.Springer Nature. doi: 10.1007/s11682-021-00536-2.
Banihashemi, L., Peng, C.W., Verstynen, T., Wallace, M.L., Lamont, D.N., Alkhars, H.M., Yeh, F.C., Beeney, J.E., Aizenstein, H.J., & Germain, A. (2021). Opposing relationships of childhood threat and deprivation with stria terminalis white matter. Hum Brain Mapp, 42(8), 2445-2460.Wiley. doi: 10.1002/hbm.25378.
Cui, C., Higashiyama, A., Lopresti, B.J., Ihara, M., Aizenstein, H.J., Watanabe, M., Chang, Y., Kakuta, C., Yu, Z., Mathis, C.A., Kokubo, Y., Fukuda, T., Villemagne, V.L., Klunk, W.E., Lopez, O.L., Kuller, L.H., Miyamoto, Y., & Sekikawa, A. (2021). Comparing Pathological Risk Factors for Dementia between Cognitively Normal Japanese and Americans. Brain Sci, 11(9).MDPI. doi: 10.3390/brainsci11091180.
Eshaghzadeh Torbati, M., Minhas, D.S., Ahmad, G., O'Connor, E.E., Muschelli, J., Laymon, C.M., Yang, Z., Cohen, A.D., Aizenstein, H.J., Klunk, W.E., Christian, B.T., Hwang, S.J., Crainiceanu, C.M., & Tudorascu, D.L. (2021). A multi-scanner neuroimaging data harmonization using RAVEL and ComBat. Neuroimage, 245, 118703.Elsevier. doi: 10.1016/j.neuroimage.2021.118703.
Gerlach, A.R., Karim, H.T., Kazan, J., Aizenstein, H.J., Krafty, R.T., & Andreescu, C. (2021). Networks of worry-towards a connectivity-based signature of late-life worry using higher criticism. Transl Psychiatry, 11(1), 550.Springer Nature. doi: 10.1038/s41398-021-01648-5.
Goldberg, S.M., Lopez, O.L., Cohen, A.D., Klunk, W.E., Aizenstein, H.A., Mizuno, A., & Snitz, B.E. (2021). The roles of study setting, response bias, and personality in subjective memory complaints of cognitively normal older adults. Int Psychogeriatr, 33(7), 665-676.Elsevier. doi: 10.1017/S1041610220000319.
Jedema, H.P., Song, X., Aizenstein, H.J., Bonner, A.R., Stein, E.A., Yang, Y., & Bradberry, C.W. (2021). Long-Term Cocaine Self-administration Produces Structural Brain Changes That Correlate With Altered Cognition. Biol Psychiatry, 89(4), 376-385.Elsevier. doi: 10.1016/j.biopsych.2020.08.008.
Karim, H.T., Ly, M., Yu, G., Krafty, R., Tudorascu, D.L., Aizenstein, H.J., & Andreescu, C. (2021). Aging faster: worry and rumination in late life are associated with greater brain age. Neurobiol Aging, 101, 13-21.Elsevier. doi: 10.1016/j.neurobiolaging.2021.01.009.
Laymon, C.M., Minhas, D.S., Royse, S.K., Aizenstein, H.J., Cohen, A.D., Tudorascu, D.L., & Klunk, W.E. (2021). Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [11C]PiB amyloid imaging. EJNMMI Phys, 8(1), 54.Springer Nature. doi: 10.1186/s40658-021-00403-5.
Ly, M., Karim, H.T., Becker, J.T., Lopez, O.L., Anderson, S.J., Aizenstein, H.J., Reynolds, C.F., Zmuda, M.D., & Butters, M.A. (2021). Late-life depression and increased risk of dementia: a longitudinal cohort study. Transl Psychiatry, 11(1), 147.Springer Nature. doi: 10.1038/s41398-021-01269-y.
Mizuno, A., Karim, H.T., Ly, M.J., Cohen, A.D., Lopresti, B.J., Mathis, C.A., Klunk, W.E., Aizenstein, H.J., & Snitz, B.E. (2021). An Effect of Education on Memory-Encoding Activation in Subjective Cognitive Decline. In Boccia, M. (Ed.). J Alzheimers Dis, 81(3), 1065-1078.SAGE Publications. doi: 10.3233/JAD-201087.
Oberlin, L.E., Erickson, K.I., Mackey, R., Klunk, W.E., Aizenstein, H., Lopresti, B.J., Kuller, L.H., Lopez, O.L., & Snitz, B.E. (2021). Peripheral inflammatory biomarkers predict the deposition and progression of amyloid-β in cognitively unimpaired older adults. Brain Behav Immun, 95, 178-189.Elsevier. doi: 10.1016/j.bbi.2021.03.015.
Santini, T., Koo, M., Farhat, N., Campos, V.P., Alkhateeb, S., Vieira, M.A.C., Butters, M.A., Rosano, C., Aizenstein, H.J., Mettenburg, J., Novelli, E.M., & Ibrahim, T.S. (2021). Analysis of hippocampal subfields in sickle cell disease using ultrahigh field MRI. Neuroimage Clin, 30, 102655.Elsevier. doi: 10.1016/j.nicl.2021.102655.
Santini, T., Wood, S., Krishnamurthy, N., Martins, T., Aizenstein, H.J., & Ibrahim, T.S. (2021). Improved 7 Tesla transmit field homogeneity with reduced electromagnetic power deposition using coupled Tic Tac Toe antennas. Sci Rep, 11(1), 3370.Springer Nature. doi: 10.1038/s41598-020-79807-9.
Smagula, S.F., Karim, H.T., Ibrahim, T.S., Krafty, R.T., Stahl, S.T., Rodakowski, J., Reynolds, C.F., Hall, M.H., & Aizenstein, H.J. (2021). Resting-State Function Connectivity Associated With Being a "Morning-Type" Dementia Caregiver and Having Lower Depression Symptom Severity. In Taler, V. (Ed.). J Gerontol B Psychol Sci Soc Sci, 76(6), 1071-1076.Oxford University Press (OUP). doi: 10.1093/geronb/gbaa115.
Sullivan, K.J., Liu, A., Chang, C.C.H., Cohen, A.D., Lopresti, B.J., Minhas, D.S., Laymon, C.M., Klunk, W.E., Aizenstein, H., Nadkarni, N.K., Loewenstein, D., Kamboh, M.I., Ganguli, M., & Snitz, B.E. (2021). Alzheimer's disease pathology in a community-based sample of older adults without dementia: The MYHAT neuroimaging study. Brain Imaging Behav, 15(3), 1355-1363.Springer Nature. doi: 10.1007/s11682-020-00334-2.
Villemagne, V.L., Lopresti, B.J., Doré, V., Tudorascu, D., Ikonomovic, M.D., Burnham, S., Minhas, D., Pascoal, T.A., Mason, N.S., Snitz, B., Aizenstein, H., Mathis, C.A., Lopez, O., Rowe, C.C., Klunk, W.E., & Cohen, A.D. (2021). What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies. J Nucl Med, 62(5), 614-619.Society of Nuclear Medicine. doi: 10.2967/jnumed.120.245423.
Yan, Q., Nho, K., Del-Aguila, J.L., Wang, X., Risacher, S.L., Fan, K.H., Snitz, B.E., Aizenstein, H.J., Mathis, C.A., Lopez, O.L., Demirci, F.Y., Feingold, E., Klunk, W.E., Saykin, A.J., Alzheimer’s Disease Neuroimaging Initiative (ADNI), Cruchaga, C., & Kamboh, M.I. (2021). Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging. Mol Psychiatry, 26(1), 309-321.Springer Nature. doi: 10.1038/s41380-018-0246-7.
Yu, G.Z., Ly, M., Karim, H.T., Muppidi, N., Aizenstein, H.J., & Ibinson, J.W. (2021). Accelerated brain aging in chronic low back pain. Brain Res, 1755, 147263.Elsevier. doi: 10.1016/j.brainres.2020.147263.
Cui, C., Birru, R.L., Snitz, B.E., Ihara, M., Kakuta, C., Lopresti, B.J., Aizenstein, H.J., Lopez, O.L., Mathis, C.A., Miyamoto, Y., Kuller, L.H., & Sekikawa, A. (2020). Effects of soy isoflavones on cognitive function: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev, 78(2), 134-144.Oxford University Press (OUP). doi: 10.1093/nutrit/nuz050.
Ding, T., Cohen, A.D., O'Connor, E.E., Karim, H.T., Crainiceanu, A., Muschelli, J., Lopez, O., Klunk, W.E., Aizenstein, H.J., Krafty, R., Crainiceanu, C.M., & Tudorascu, D.L. (2020). An improved algorithm of white matter hyperintensity detection in elderly adults. Neuroimage Clin, 25, 102151.Elsevier. doi: 10.1016/j.nicl.2019.102151.
DiSalvio, N.L., Rosano, C., Aizenstein, H.J., Redfern, M.S., Furman, J.M., Jennings, J.R., Whitney, S.L., & Sparto, P.J. (2020). Gray Matter Regions Associated With Functional Mobility in Community-Dwelling Older Adults. J Am Geriatr Soc, 68(5), 1023-1028.Wiley. doi: 10.1111/jgs.16309.
Handen, B.L., Lott, I.T., Christian, B.T., Schupf, N., OBryant, S., Mapstone, M., Fagan, A.M., Lee, J.H., Tudorascu, D., Wang, M.C., Head, E., Klunk, W., Ances, B., Lai, F., Zaman, S., Krinsky-McHale, S., Brickman, A.M., Rosas, H.D., Cohen, A., Andrews, H., Hartley, S., Silverman, W., & Alzheimer's Biomarker Consortium‐Down Syndrome (ABC‐DS). (2020). The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimers Dement (Amst), 12(1), e12065.Wiley. doi: 10.1002/dad2.12065.
Karim, H.T., Rosso, A., Aizenstein, H.J., Bohnen, N.I., Studenski, S., & Rosano, C. (2020). Resting state connectivity within the basal ganglia and gait speed in older adults with cerebral small vessel disease and locomotor risk factors. Neuroimage Clin, 28, 102401.Elsevier. doi: 10.1016/j.nicl.2020.102401.
Lee, D.Y., Cho, J., You, S.C., Park, R.W., Kim, C.S., Lee, E.Y., Aizenstein, H., Andreescu, C., Karim, H., Hong, C.H., Rho, H.W., Park, B., & Son, S.J. (2020). Risk of Mortality in Elderly Coronavirus Disease 2019 Patients With Mental Health Disorders: A Nationwide Retrospective Study in South Korea. Am J Geriatr Psychiatry, 28(12), 1308-1316.Elsevier. doi: 10.1016/j.jagp.2020.09.016.
Lin, C., Huang, C.M., Fan, Y.T., Liu, H.L., Chen, Y.L., Aizenstein, H.J., Lee, T.M.C., & Lee, S.H. (2020). Cognitive Reserve Moderates Effects of White Matter Hyperintensity on Depressive Symptoms and Cognitive Function in Late-Life Depression. Front Psychiatry, 11, 249.Frontiers. doi: 10.3389/fpsyt.2020.00249.
Lin, C., Ly, M., Karim, H.T., Wei, W., Snitz, B.E., Klunk, W.E., & Aizenstein, H.J. (2020). The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults. Alzheimers Res Ther, 12(1), 7.Springer Nature. doi: 10.1186/s13195-019-0573-1.
Lopresti, B.J., Campbell, E.M., Yu, Z., Anderson, S.J., Cohen, A.D., Minhas, D.S., Snitz, B.E., Royse, S.K., Becker, C.R., Aizenstein, H.J., Mathis, C.A., Lopez, O.L., Klunk, W.E., & Tudorascu, D.L. (2020). Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories. Neurobiol Aging, 94, 111-120.Elsevier. doi: 10.1016/j.neurobiolaging.2020.05.012.
Ly, M., Yu, G.Z., Karim, H.T., Muppidi, N.R., Mizuno, A., Klunk, W.E., Aizenstein, H.J., & Alzheimer's Disease Neuroimaging Initiative. (2020). Improving brain age prediction models: incorporation of amyloid status in Alzheimer's disease. Neurobiol Aging, 87, 44-48.Elsevier. doi: 10.1016/j.neurobiolaging.2019.11.005.
Newmark, J., Gebara, M.A., Aizenstein, H., & Karp, J.F. (2020). Engaging in Late-Life Mental Health Research: a Narrative Review of Challenges to Participation. Curr Treat Options Psychiatry, 7(3), 317-336.Springer Nature. doi: 10.1007/s40501-020-00217-9.
Petersen, M.E., Zhang, F., Schupf, N., Krinsky-McHale, S.J., Hall, J., Mapstone, M., Cheema, A., Silverman, W., Lott, I., Rafii, M.S., Handen, B., Klunk, W., Head, E., Christian, B., Foroud, T., Lai, F., Rosas, H.D., Zaman, S., Ances, B.M., Wang, M.C., Tycko, B., Lee, J.H., O'Bryant, S., & Alzheimer's Biomarker Consortium – Down Syndrome (ABC‐DS). (2020). Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimers Dement (Amst), 12(1), e12039.Wiley. doi: 10.1002/dad2.12039.
Sekikawa, A., Higashiyama, A., Lopresti, B.J., Ihara, M., Aizenstein, H., Watanabe, M., Chang, Y., Kakuta, C., Yu, Z., Mathis, C., Kokubo, Y., Klunk, W., Lopez, O.L., Kuller, L.H., Miyamoto, Y., & Cui, C. (2020). Associations of equol-producing status with white matter lesion and amyloid-β deposition in cognitively normal elderly Japanese. Alzheimers Dement (N Y), 6(1), e12089.Wiley. doi: 10.1002/trc2.12089.
Smagula, S.F., Chahine, L., Metti, A., Rangarajan, A., Aizenstein, H.J., Tian, Q., & Rosano, C. (2020). Regional Gray Matter Volume Links Rest-Activity Rhythm Fragmentation With Past Cognitive Decline. Am J Geriatr Psychiatry, 28(2), 248-251.Elsevier. doi: 10.1016/j.jagp.2019.07.009.
Smagula, S.F., Stahl, S.T., Santini, T., Banihashemi, L., Hall, M.H., Ibrahim, T.S., Reynolds, C.F., Krafty, R.T., Aizenstein, H.J., & Zhan, L. (2020). White Matter Integrity Underlying Depressive Symptoms in Dementia Caregivers. Am J Geriatr Psychiatry, 28(5), 578-582.Elsevier. doi: 10.1016/j.jagp.2019.11.010.
Snitz, B.E., Chang, Y., Tudorascu, D.L., Lopez, O.L., Lopresti, B.J., DeKosky, S.T., Carlson, M.C., Cohen, A.D., Kamboh, M.I., Aizenstein, H.J., Klunk, W.E., & Kuller, L.H. (2020). Predicting resistance to amyloid-beta deposition and cognitive resilience in the oldest-old. Neurology, 95(8), e984-e994.Wolters Kluwer. doi: 10.1212/WNL.0000000000010239.
Snitz, B.E., Tudorascu, D.L., Yu, Z., Campbell, E., Lopresti, B.J., Laymon, C.M., Minhas, D.S., Nadkarni, N.K., Aizenstein, H.J., Klunk, W.E., Weintraub, S., Gershon, R.C., & Cohen, A.D. (2020). Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non-demented older adults. Alzheimers Dement (Amst), 12(1), e12018.Wiley. doi: 10.1002/dad2.12018.
Thurston, R.C., Wu, M., Aizenstein, H.J., Chang, Y., Barinas Mitchell, E., Derby, C.A., & Maki, P.M. (2020). Sleep characteristics and white matter hyperintensities among midlife women. Sleep, 43(6).Oxford University Press (OUP). doi: 10.1093/sleep/zsz298.
Andreescu, C., Ajilore, O., Aizenstein, H.J., Albert, K., Butters, M.A., Landman, B.A., Karim, H.T., Krafty, R., & Taylor, W.D. (2019). Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression. Am J Geriatr Psychiatry, 27(12), 1316-1330.Elsevier. doi: 10.1016/j.jagp.2019.07.016.
Beer, J.C., Aizenstein, H.J., Anderson, S.J., & Krafty, R.T. (2019). Incorporating prior information with fused sparse group lasso: Application to prediction of clinical measures from neuroimages. Biometrics, 75(4), 1299-1309.Oxford University Press (OUP). doi: 10.1111/biom.13075.
Farhat, N.S., Theiss, R., Santini, T., Ibrahim, T.S., & Aizenstein, H.J. (2019). Neuroimaging of Small Vessel Disease in Late-Life Depression. Adv Exp Med Biol, 1192, 95-115.Springer Nature. doi: 10.1007/978-981-32-9721-0_5.
Gujral, S., Aizenstein, H., Reynolds, C.F., Butters, M.A., Grove, G., Karp, J.F., & Erickson, K.I. (2019). Exercise for Depression: A Feasibility Trial Exploring Neural Mechanisms. Am J Geriatr Psychiatry, 27(6), 611-616.Elsevier. doi: 10.1016/j.jagp.2019.01.012.
Karim, H.T., Tudorascu, D.L., Cohen, A., Price, J.C., Lopresti, B., Mathis, C., Klunk, W., Snitz, B.E., & Aizenstein, H.J. (2019). Relationships Between Executive Control Circuit Activity, Amyloid Burden, and Education in Cognitively Healthy Older Adults. Am J Geriatr Psychiatry, 27(12), 1360-1371.Elsevier. doi: 10.1016/j.jagp.2019.07.008.
Krishnamurthy, N., Santini, T., Wood, S., Kim, J., Zhao, T., Aizenstein, H.J., & Ibrahim, T.S. (2019). Computational and experimental evaluation of the Tic-Tac-Toe RF coil for 7 Tesla MRI. In Orzada, S. (Ed.). PLoS One, 14(1), e0209663.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0209663.
Lin, C., Karim, H.T., Pecina, M., Aizenstein, H.J., Lenze, E.J., Blumberger, D.M., Mulsant, B.H., Kharasch, E.D., Reynolds Iii, C.F., & Karp, J.F. (2019). Low-dose augmentation with buprenorphine increases emotional reactivity but not reward activity in treatment resistant mid- and late-life depression. Neuroimage Clin, 21, 101679.Elsevier. doi: 10.1016/j.nicl.2019.101679.
Manning, K.J., Gunning, F.M., Aizenstein, H.J., & Steffens, D.C. (2019). Training the Next Generation of Geriatric-Focused Clinical Neuroscientists. Am J Geriatr Psychiatry, 27(7), 720-727.Elsevier. doi: 10.1016/j.jagp.2019.03.006.
Massa, R.E., Rosso, A., Metti, A.L., Sparto, P.J., Aizenstein, H., Ferrucci, L., Divecha, A., Rosano, C., & Health ABC Study. (2019). Neuroimaging correlates of lateral postural control in older ambulatory adults. Aging Clin Exp Res, 31(5), 611-619.Springer Nature. doi: 10.1007/s40520-018-1028-4.
Mendes-Silva, A.P., Mwangi, B., Aizenstein, H., Reynolds, C.F., Butters, M.A., & Diniz, B.S. (2019). Molecular Senescence Is Associated With White Matter Microstructural Damage in Late-Life Depression. Am J Geriatr Psychiatry, 27(12), 1414-1418.Elsevier. doi: 10.1016/j.jagp.2019.06.006.
Nadkarni, N.K., Tudorascu, D., Campbell, E., Snitz, B.E., Cohen, A.D., Halligan, E., Mathis, C.A., Aizenstein, H.J., & Klunk, W.E. (2019). Association Between Amyloid-β, Small-vessel Disease, and Neurodegeneration Biomarker Positivity, and Progression to Mild Cognitive Impairment in Cognitively Normal Individuals. In Melzer, D. (Ed.). J Gerontol A Biol Sci Med Sci, 74(11), 1753-1760.Oxford University Press (OUP). doi: 10.1093/gerona/glz088.
Nunley, K.A., Karp, J.F., Orchard, T.J., Costacou, T., Aizenstein, H.J., Jennings, J.R., & Rosano, C. (2019). Depressive symptoms and cerebral microvascular disease in adults with Type 1 diabetes mellitus. Diabet Med, 36(9), 1168-1175.Wiley. doi: 10.1111/dme.13879.
Sekikawa, A., Ihara, M., Lopez, O., Kakuta, C., Lopresti, B., Higashiyama, A., Aizenstein, H., Chang, Y.F., Mathis, C., Miyamoto, Y., Kuller, L., & Cui, C. (2019). Effect of S-equol and Soy Isoflavones on Heart and Brain. Curr Cardiol Rev, 15(2), 114-135.Bentham Science Publishers. doi: 10.2174/1573403X15666181205104717.
Shaaban, C.E., Aizenstein, H.J., Jorgensen, D.R., Mahbubani, R.L.M., Meckes, N.A., Erickson, K.I., Glynn, N.W., Mettenburg, J., Guralnik, J., Newman, A.B., Ibrahim, T.S., Laurienti, P.J., Vallejo, A.N., & Rosano, C. (2019). Physical Activity and Cerebral Small Vein Integrity in Older Adults. Med Sci Sports Exerc, 51(8), 1684-1691.Wolters Kluwer. doi: 10.1249/MSS.0000000000001952.
Tudorascu, D.L., Anderson, S.J., Minhas, D.S., Yu, Z., Comer, D., Lao, P., Hartley, S., Laymon, C.M., Snitz, B.E., Lopresti, B.J., Johnson, S., Price, J.C., Mathis, C.A., Aizenstein, H.J., Klunk, W.E., Handen, B.L., Christian, B.T., & Cohen, A.D. (2019). Comparison of longitudinal Aβ in nondemented elderly and Down syndrome. Neurobiol Aging, 73, 171-176.Elsevier. doi: 10.1016/j.neurobiolaging.2018.09.030.
Wasson, E., Rosso, A.L., Santanasto, A.J., Rosano, C., Butters, M.A., Rejeski, W.J., Boudreau, R.M., Aizenstein, H., Gmelin, T., Glynn, N.W., & LIFE Study Group. (2019). Neural correlates of perceived physical and mental fatigability in older adults: A pilot study. Exp Gerontol, 115, 139-147.Elsevier. doi: 10.1016/j.exger.2018.12.003.
Wu, M., Mennin, D.S., Ly, M., Karim, H.T., Banihashemi, L., Tudorascu, D.L., Aizenstein, H.J., & Andreescu, C. (2019). When worry may be good for you: Worry severity and limbic-prefrontal functional connectivity in late-life generalized anxiety disorder. J Affect Disord, 257, 650-657.Elsevier. doi: 10.1016/j.jad.2019.07.022.
Wu, M., Thurston, R.C., Tudorascu, D.L., Karim, H.T., Mathis, C.A., Lopresti, B.J., Kamboh, M.I., Cohen, A.D., Snitz, B.E., Klunk, W.E., & Aizenstein, H.J. (2019). Amyloid deposition is associated with different patterns of hippocampal connectivity in men versus women. Neurobiol Aging, 76, 141-150.Elsevier. doi: 10.1016/j.neurobiolaging.2018.11.020.
Karim, H.T., Wang, M., Andreescu, C., Tudorascu, D., Butters, M.A., Karp, J.F., Reynolds, C.F., & Aizenstein, H.J. (2018). Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression. Neuroimage Clin, 19, 831-839.Elsevier. doi: 10.1016/j.nicl.2018.06.006.
Lopez, O.L., Becker, J.T., Chang, Y., Klunk, W.E., Mathis, C., Price, J., Aizenstein, H.J., Snitz, B., Cohen, A.D., DeKosky, S.T., Ikonomovic, M., Kamboh, M.I., & Kuller, L.H. (2018). Amyloid deposition and brain structure as long-term predictors of MCI, dementia, and mortality. Neurology, 90(21), e1920-e1928.Wolters Kluwer. doi: 10.1212/WNL.0000000000005549.
Lyons, C.E., Tudorascu, D., Snitz, B.E., Price, J., Aizenstein, H., Lopez, O., Lopresti, B., Laymon, C., Minhas, D., Kamboh, I., Mathis, C., Klunk, W., & Cohen, A.D. (2018). The Relationship of Current Cognitive Activity to Brain Amyloid Burden and Glucose Metabolism. Am J Geriatr Psychiatry, 26(9), 977-984.Elsevier. doi: 10.1016/j.jagp.2018.03.018.
Mizuno, A., Ly, M., & Aizenstein, H.J. (2018). A Homeostatic Model of Subjective Cognitive Decline. Brain Sci, 8(12).MDPI. doi: 10.3390/brainsci8120228.
Nunley, K.A., Metti, A.L., Klein, R., Klein, B.E., Saxton, J.A., Orchard, T.J., Costacou, T., Aizenstein, H.J., & Rosano, C. (2018). Long-term changes in retinal vascular diameter and cognitive impairment in type 1 diabetes. Diab Vasc Dis Res, 15(3), 223-232.SAGE Publications. doi: 10.1177/1479164118758581.
Rosso, A.L., Bohnen, N.I., Launer, L.J., Aizenstein, H.J., Yaffe, K., & Rosano, C. (2018). Vascular and dopaminergic contributors to mild parkinsonian signs in older adults. Neurology, 90(3), e223-e229.Wolters Kluwer. doi: 10.1212/WNL.0000000000004842.
Ryan, J.P., Aizenstein, H.J., Orchard, T.J., Nunley, K.A., Karim, H., & Rosano, C. (2018). Basal ganglia cerebral blood flow associates with psychomotor speed in adults with type 1 diabetes. Brain Imaging Behav, 12(5), 1271-1278.Springer Nature. doi: 10.1007/s11682-017-9783-y.
Ryan, J.P., Karim, H.T., Aizenstein, H.J., Helbling, N.L., & Toledo, F.G.S. (2018). Insulin sensitivity predicts brain network connectivity following a meal. Neuroimage, 171, 268-276.Elsevier. doi: 10.1016/j.neuroimage.2018.01.024.
Santini, T., Zhao, Y., Wood, S., Krishnamurthy, N., Kim, J., Farhat, N., Alkhateeb, S., Martins, T., Koo, M., Zhao, T., Aizenstein, H.J., & Ibrahim, T.S. (2018). In-vivo and numerical analysis of the eigenmodes produced by a multi-level Tic-Tac-Toe head transmit array for 7 Tesla MRI. In Lundberg, P. (Ed.). PLoS One, 13(11), e0206127.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0206127.
Shaaban, C.E., Aizenstein, H.J., & Jorgensen, D.R. (2018). Erratum. AJNR Am J Neuroradiol, 39(12), E132.American Society of Neuroradiology (ASNR). doi: 10.3174/ajnr.A5880.
Smagula, S.F., Karim, H.T., Rangarajan, A., Santos, F.P., Wood, S.C., Santini, T., Jakicic, J.M., Reynolds, C.F., Cameron, J.L., Vallejo, A.N., Butters, M.A., Rosano, C., Ibrahim, T.S., Erickson, K.I., & Aizenstein, H.J. (2018). Association of Hippocampal Substructure Resting-State Functional Connectivity with Memory Performance in Older Adults. Am J Geriatr Psychiatry, 26(6), 690-699.Elsevier. doi: 10.1016/j.jagp.2018.03.003.
Wei, W., Karim, H.T., Lin, C., Mizuno, A., Andreescu, C., Karp, J.F., Reynolds, C.F., & Aizenstein, H.J. (2018). Trajectories in Cerebral Blood Flow Following Antidepressant Treatment in Late-Life Depression: Support for the Vascular Depression Hypothesis. J Clin Psychiatry, 79(6).Physicians Postgraduate Press. doi: 10.4088/JCP.18m12106.
Wilckens, K.A., Tudorascu, D.L., Snitz, B.E., Price, J.C., Aizenstein, H.J., Lopez, O.L., Erickson, K.I., Lopresti, B.J., Laymon, C.M., Minhas, D., Mathis, C.A., Buysse, D.J., Klunk, W.E., & Cohen, A.D. (2018). Sleep moderates the relationship between amyloid beta and memory recall. Neurobiol Aging, 71, 142-148.Elsevier. doi: 10.1016/j.neurobiolaging.2018.07.011.
Zhao, Y., Tudorascu, D.L., Lopez, O.L., Cohen, A.D., Mathis, C.A., Aizenstein, H.J., Price, J.C., Kuller, L.H., Kamboh, M.I., DeKosky, S.T., Klunk, W.E., & Snitz, B.E. (2018). Amyloid β Deposition and Suspected Non-Alzheimer Pathophysiology and Cognitive Decline Patterns for 12 Years in Oldest Old Participants Without Dementia. JAMA Neurol, 75(1), 88-96.American Medical Association (AMA). doi: 10.1001/jamaneurol.2017.3029.
Andreescu, C., Tudorascu, D., Sheu, L.K., Rangarajan, A., Butters, M.A., Walker, S., Berta, R., Desmidt, T., & Aizenstein, H. (2017). Brain structural changes in late-life generalized anxiety disorder. Psychiatry Res Neuroimaging, 268, 15-21.Elsevier. doi: 10.1016/j.pscychresns.2017.08.004.
Best, J.R., Rosano, C., Aizenstein, H.J., Tian, Q., Boudreau, R.M., Ayonayon, H.N., Satterfield, S., Simonsick, E.M., Studenski, S., Yaffe, K., Liu-Ambrose, T., & Health, Aging and Body Composition Study. (2017). Long-term changes in time spent walking and subsequent cognitive and structural brain changes in older adults. Neurobiol Aging, 57, 153-161.Elsevier. doi: 10.1016/j.neurobiolaging.2017.05.023.
Desmidt, T., Brizard, B., Dujardin, P.A., Ternifi, R., Réméniéras, J.P., Patat, F., Andersson, F., Cottier, J.P., Vierron, E., Gissot, V., Kim, K., Aizenstein, H., El-Hage, W., & Camus, V. (2017). Brain Tissue Pulsatility is Increased in Midlife Depression: a Comparative Study Using Ultrasound Tissue Pulsatility Imaging. Neuropsychopharmacology, 42(13), 2575-2582.Springer Nature. doi: 10.1038/npp.2017.113.
Diniz, B.S., Reynolds, C.F., Sibille, E., Lin, C.W., Tseng, G., Lotrich, F., Aizenstein, H.J., & Butters, M.A. (2017). Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype. Am J Geriatr Psychiatry, 25(1), 64-72.Elsevier. doi: 10.1016/j.jagp.2016.08.018.
Droppa, K., Karim, H.T., Tudorascu, D.L., Karp, J.F., Reynolds, C.F., Aizenstein, H.J., & Butters, M.A. (2017). Association between change in brain gray matter volume, cognition, and depression severity: Pre- and post- antidepressant pharmacotherapy for late-life depression. J Psychiatr Res, 95, 129-134.Elsevier. doi: 10.1016/j.jpsychires.2017.08.002.
Gujral, S., Aizenstein, H., Reynolds, C.F., Butters, M.A., & Erickson, K.I. (2017). Exercise effects on depression: Possible neural mechanisms. Gen Hosp Psychiatry, 49, 2-10.Elsevier. doi: 10.1016/j.genhosppsych.2017.04.012.
Hwang, M., Tudorascu, D.L., Nunley, K., Karim, H., Aizenstein, H.J., Orchard, T.J., & Rosano, C. (2017). Corrigendum to "Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease". J Diabetes Res, 2017(1), 4295645.Hindawi. doi: 10.1155/2017/4295645.
Karim, H.T., Andreescu, C., Tudorascu, D., Smagula, S.F., Butters, M.A., Karp, J.F., Reynolds, C., & Aizenstein, H.J. (2017). Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters. Mol Psychiatry, 22(3), 450-457.Springer Nature. doi: 10.1038/mp.2016.55.
Karim, H.T., Tudorascu, D.L., Butters, M.A., Walker, S., Aizenstein, H.J., & Andreescu, C. (2017). In the grip of worry: cerebral blood flow changes during worry induction and reappraisal in late-life generalized anxiety disorder. Transl Psychiatry, 7(9), e1244.Springer Nature. doi: 10.1038/tp.2017.215.
Karim, H.T., Tudorascu, D.L., Butters, M.A., Walker, S., Aizenstein, H.J., & Andreescu, C. (2017). In the grip of worry: cerebral blood flow changes during worry induction and reappraisal in late-life generalized anxiety disorder. Transl Psychiatry, 7(8), e1204.Springer Nature. doi: 10.1038/tp.2017.180.
Nunley, K.A., Leckie, R.L., Orchard, T.J., Costacou, T., Aizenstein, H.J., Jennings, J.R., Erickson, K.I., & Rosano, C. (2017). Physical activity and hippocampal volume in middle-aged patients with type 1 diabetes. Neurology, 88(16), 1564-1570.Wolters Kluwer. doi: 10.1212/WNL.0000000000003805.
Nunley, K.A., Ryan, C.M., Aizenstein, H.J., Jennings, J.R., MacCloud, R.L., Orchard, T.J., & Rosano, C. (2017). Regional Gray Matter Volumes as Related to Psychomotor Slowing in Adults with Type 1 Diabetes. Psychosom Med, 79(5), 533-540.Wolters Kluwer. doi: 10.1097/PSY.0000000000000449.
O'Hare, C., Kenny, R.A., Aizenstein, H., Boudreau, R., Newman, A., Launer, L., Satterfield, S., Yaffe, K., Rosano, C., & Health ABC Study. (2017). Cognitive Status, Gray Matter Atrophy, and Lower Orthostatic Blood Pressure in Older Adults. J Alzheimers Dis, 57(4), 1239-1250.SAGE Publications. doi: 10.3233/JAD-161228.
Rosano, C., Guralnik, J., Pahor, M., Glynn, N.W., Newman, A.B., Ibrahim, T.S., Erickson, K., Cohen, R., Shaaban, C.E., MacCloud, R.L., & Aizenstein, H.J. (2017). Hippocampal Response to a 24-Month Physical Activity Intervention in Sedentary Older Adults. Am J Geriatr Psychiatry, 25(3), 209-217.Elsevier. doi: 10.1016/j.jagp.2016.11.007.
Rosso, A.L., Verghese, J., Metti, A.L., Boudreau, R.M., Aizenstein, H.J., Kritchevsky, S., Harris, T., Yaffe, K., Satterfield, S., Studenski, S., & Rosano, C. (2017). Slowing gait and risk for cognitive impairment: The hippocampus as a shared neural substrate. Neurology, 89(4), 336-342.Wolters Kluwer. doi: 10.1212/WNL.0000000000004153.
Shaaban, C.E., Aizenstein, H.J., Jorgensen, D.R., MacCloud, R.L., Meckes, N.A., Erickson, K.I., Glynn, N.W., Mettenburg, J., Guralnik, J., Newman, A.B., Ibrahim, T.S., Laurienti, P.J., Vallejo, A.N., Rosano, C., & LIFE Study Group. (2017). In Vivo Imaging of Venous Side Cerebral Small-Vessel Disease in Older Adults: An MRI Method at 7T. AJNR Am J Neuroradiol, 38(10), 1923-1928.American Society of Neuroradiology (ASNR). doi: 10.3174/ajnr.A5327.
Smagula, S.F., Karim, H.T., Lenze, E.J., Butters, M.A., Wu, G.F., Mulsant, B.H., Reynolds, C.F., & Aizenstein, H.J. (2017). Gray matter regions statistically mediating the cross-sectional association of eotaxin and set-shifting among older adults with major depressive disorder. Int J Geriatr Psychiatry, 32(12), 1226-1232.Wiley. doi: 10.1002/gps.4585.
Smagula, S.F., Lotrich, F.E., Aizenstein, H.J., Diniz, B.S., Krystek, J., Wu, G.F., Mulsant, B.H., Butters, M.A., Reynolds, C.F., & Lenze, E.J. (2017). Immunological biomarkers associated with brain structure and executive function in late-life depression: exploratory pilot study. Int J Geriatr Psychiatry, 32(6), 692-699.Wiley. doi: 10.1002/gps.4512.
Wu, M., & Aizenstein, H.J. (2017). The Multi-Faceted Relationship between White Matter Lesions and Late-Life Depression. Am J Geriatr Psychiatry, 25(12), 1322-1325.Elsevier. doi: 10.1016/j.jagp.2017.09.017.
Aizenstein, H.J., Baskys, A., Boldrini, M., Butters, M.A., Diniz, B.S., Jaiswal, M.K., Jellinger, K.A., Kruglov, L.S., Meshandin, I.A., Mijajlovic, M.D., Niklewski, G., Pospos, S., Raju, K., Richter, K., Steffens, D.C., Taylor, W.D., & Tene, O. (2016). Vascular depression consensus report - a critical update. BMC Med, 14(1), 161.Springer Nature. doi: 10.1186/s12916-016-0720-5.
Andreescu, C., & Aizenstein, H. (2016). Predicting Treatment Response With Functional Magnetic Resonance Imaging. Biol Psychiatry, 79(4), 262-263.Elsevier. doi: 10.1016/j.biopsych.2015.11.017.
Andreescu, C., & Aizenstein, H.J. (2016). New Findings on the Neurobiology of Dementia and Dementia Risk. Am J Geriatr Psychiatry, 24(2), 105-106.Elsevier. doi: 10.1016/j.jagp.2015.10.003.
Cohen, A.D., & Aizenstein, H.J. (2016). Brain Amyloidosis and Triglycerides: Preventing Alzheimer Disease Pathology by Treating Vascular Disease?. Am J Geriatr Psychiatry, 24(8), 613-614.Elsevier. doi: 10.1016/j.jagp.2016.04.007.
Diniz, B.S., Lin, C.W., Sibille, E., Tseng, G., Lotrich, F., Aizenstein, H.J., Reynolds, C.F., & Butters, M.A. (2016). Circulating biosignatures of late-life depression (LLD): Towards a comprehensive, data-driven approach to understanding LLD pathophysiology. J Psychiatr Res, 82, 1-7.Elsevier. doi: 10.1016/j.jpsychires.2016.07.006.
Hwang, M., Tudorascu, D.L., Nunley, K., Karim, H., Aizenstein, H.J., Orchard, T.J., & Rosano, C. (2016). Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease. J Diabetes Res, 2016(1), 9571464.Hindawi. doi: 10.1155/2016/9571464.
Kaneriya, S.H., Robbins-Welty, G.A., Smagula, S.F., Karp, J.F., Butters, M.A., Lenze, E.J., Mulsant, B.H., Blumberger, D., Anderson, S.J., Dew, M.A., Lotrich, F., Aizenstein, H.J., Diniz, B.S., & Reynolds, C.F. (2016). Predictors and Moderators of Remission With Aripiprazole Augmentation in Treatment-Resistant Late-Life Depression: An Analysis of the IRL-GRey Randomized Clinical Trial. JAMA Psychiatry, 73(4), 329-336.American Medical Association (AMA). doi: 10.1001/jamapsychiatry.2015.3447.
Karim, H., Tudorascu, D.L., Aizenstein, H., Walker, S., Good, R., & Andreescu, C. (2016). Emotion Reactivity and Cerebrovascular Burden in Late-Life GAD: A Neuroimaging Study. Am J Geriatr Psychiatry, 24(11), 1040-1050.Elsevier. doi: 10.1016/j.jagp.2016.07.015.
Karim, H.T., Andreescu, C., MacCloud, R.L., Butters, M.A., Reynolds, C.F., Aizenstein, H.J., & Tudorascu, D.L. (2016). The effects of white matter disease on the accuracy of automated segmentation. Psychiatry Res Neuroimaging, 253, 7-14.Elsevier. doi: 10.1016/j.pscychresns.2016.05.003.
Kay, D.B., Karim, H.T., Soehner, A.M., Hasler, B.P., Wilckens, K.A., James, J.A., Aizenstein, H.J., Price, J.C., Rosario, B.L., Kupfer, D.J., Germain, A., Hall, M.H., Franzen, P.L., Nofzinger, E.A., & Buysse, D.J. (2016). Sleep-Wake Differences in Relative Regional Cerebral Metabolic Rate for Glucose among Patients with Insomnia Compared with Good Sleepers. Sleep, 39(10), 1779-1794.Oxford University Press (OUP). doi: 10.5665/sleep.6154.
Khalaf, A., Karim, H., Berkout, O.V., Andreescu, C., Tudorascu, D., Reynolds, C.F., & Aizenstein, H. (2016). Altered Functional Magnetic Resonance Imaging Markers of Affective Processing During Treatment of Late-Life Depression. Am J Geriatr Psychiatry, 24(10), 791-801.Elsevier. doi: 10.1016/j.jagp.2016.03.012.
Patel, M.J., Khalaf, A., & Aizenstein, H.J. (2016). Studying depression using imaging and machine learning methods. Neuroimage Clin, 10, 115-123.Elsevier. doi: 10.1016/j.nicl.2015.11.003.
Rosario, B.L., Rosso, A.L., Aizenstein, H.J., Harris, T., Newman, A.B., Satterfield, S., Studenski, S.A., Yaffe, K., Rosano, C., & Health ABC Study. (2016). Cerebral White Matter and Slow Gait: Contribution of Hyperintensities and Normal-appearing Parenchyma. J Gerontol A Biol Sci Med Sci, 71(7), 968-973.Oxford University Press (OUP). doi: 10.1093/gerona/glv224.
Smagula, S.F., & Aizenstein, H.J. (2016). Brain structural connectivity in late-life major depressive disorder. Biol Psychiatry Cogn Neurosci Neuroimaging, 1(3), 271-277.Elsevier. doi: 10.1016/j.bpsc.2015.11.005.
Thurston, R.C., Aizenstein, H.J., Derby, C.A., Sejdić, E., & Maki, P.M. (2016). Menopausal hot flashes and white matter hyperintensities. Menopause, 23(1), 27-32.Wolters Kluwer. doi: 10.1097/GME.0000000000000481.
Tudorascu, D.L., Karim, H.T., Maronge, J.M., Alhilali, L., Fakhran, S., Aizenstein, H.J., Muschelli, J., & Crainiceanu, C.M. (2016). Reproducibility and Bias in Healthy Brain Segmentation: Comparison of Two Popular Neuroimaging Platforms. Front Neurosci, 10(NOV), 503.Frontiers. doi: 10.3389/fnins.2016.00503.
Vanyukov, P.M., Szanto, K., Hallquist, M.N., Siegle, G.J., Reynolds, C.F., Forman, S.D., Aizenstein, H.J., & Dombrovski, A.Y. (2016). Paralimbic and lateral prefrontal encoding of reward value during intertemporal choice in attempted suicide. Psychol Med, 46(2), 381-391.Cambridge University Press (CUP). doi: 10.1017/S0033291715001890.
Wilckens, K.A., Aizenstein, H.J., Nofzinger, E.A., James, J.A., Hasler, B.P., Rosario-Rivera, B.L., Franzen, P.L., Germain, A., Hall, M.H., Kupfer, D.J., Price, J.C., Siegle, G.J., & Buysse, D.J. (2016). The role of non-rapid eye movement slow-wave activity in prefrontal metabolism across young and middle-aged adults. J Sleep Res, 25(3), 296-306.Wiley. doi: 10.1111/jsr.12365.
Agudelo, C., Aizenstein, H.J., Karp, J.F., & Reynolds, C.F. (2015). Applications of magnetic resonance imaging for treatment-resistant late-life depression. Dialogues Clin Neurosci, 17(2), 151-169.Taylor & Francis. doi: 10.31887/DCNS.2015.17.2/cagudelo.
Aizenstein, H.J., & Klunk, W.E. (2015). Where is hippocampal activity in the cascade of Alzheimer's disease biomarkers?. Brain, 138(Pt 4), 831-833.Oxford University Press (OUP). doi: 10.1093/brain/awv001.
Andreescu, C., Mennin, D., Tudorascu, D., Sheu, L.K., Walker, S., Banihashemi, L., & Aizenstein, H. (2015). The many faces of anxiety-neurobiological correlates of anxiety phenotypes. Psychiatry Res, 234(1), 96-105.Elsevier. doi: 10.1016/j.pscychresns.2015.08.013.
Andreescu, C., Sheu, L.K., Tudorascu, D., Gross, J.J., Walker, S., Banihashemi, L., & Aizenstein, H. (2015). Emotion reactivity and regulation in late-life generalized anxiety disorder: functional connectivity at baseline and post-treatment. Am J Geriatr Psychiatry, 23(2), 200-214.Elsevier. doi: 10.1016/j.jagp.2014.05.003.
Bettcher, B.M., Yaffe, K., Boudreau, R.M., Neuhaus, J., Aizenstein, H., Ding, J., Kritchevsky, S.B., Launer, L.J., Liu, Y., Satterfield, S., Rosano, C., & Health ABC study. (2015). Declines in inflammation predict greater white matter microstructure in older adults. Neurobiol Aging, 36(2), 948-954.Elsevier. doi: 10.1016/j.neurobiolaging.2014.11.004.
Costacou, T., Rosano, C., Aizenstein, H., Mettenburg, J.M., Nunley, K., Ferrell, R.E., & Orchard, T.J. (2015). The haptoglobin 1 allele correlates with white matter hyperintensities in middle-aged adults with type 1 diabetes. Diabetes, 64(2), 654-659.American Diabetes Association. doi: 10.2337/db14-0723.
DeLorenzo, C., Sovago, J., Gardus, J., Xu, J., Yang, J., Behrje, R., Kumar, J.S.D., Devanand, D.P., Pelton, G.H., Mathis, C.A., Mason, N.S., Gomez-Mancilla, B., Aizenstein, H., Mann, J.J., & Parsey, R.V. (2015). Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [¹¹C]ABP688. Transl Psychiatry, 5(12), e693.Springer Nature. doi: 10.1038/tp.2015.189.
Diniz, B.S., Sibille, E., Ding, Y., Tseng, G., Aizenstein, H.J., Lotrich, F., Becker, J.T., Lopez, O.L., Lotze, M.T., Klunk, W.E., Reynolds, C.F., & Butters, M.A. (2015). Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression. Mol Psychiatry, 20(5), 594-601.Springer Nature. doi: 10.1038/mp.2014.76.
Dombrovski, A.Y., Szanto, K., Clark, L., Aizenstein, H.J., Chase, H.W., Reynolds, C.F., & Siegle, G.J. (2015). Corticostriatothalamic reward prediction error signals and executive control in late-life depression. Psychol Med, 45(7), 1413-1424.Cambridge University Press (CUP). doi: 10.1017/S0033291714002517.
Eyler, L.T., & Aizenstein, H. (2015). Neuroimaging studies of depression, dementia, and mobility in older adults. Am J Geriatr Psychiatry, 23(1), 1-3.Elsevier. doi: 10.1016/j.jagp.2014.10.008.
Flatt, J.D., Rosso, A.L., Aizenstein, H.J., Schulz, R., Longstreth, W.T., Newman, A.B., Fowler, N.R., & Rosano, C. (2015). Social Network Size and Cranial Magnetic Resonance Imaging Findings in Older Adults: The Cardiovascular Health Study. J Am Geriatr Soc, 63(11), 2430-2432.Wiley. doi: 10.1111/jgs.13805.
Gildengers, A.G., Butters, M.A., Aizenstein, H.J., Marron, M.M., Emanuel, J., Anderson, S.J., Weissfeld, L.A., Becker, J.T., Lopez, O.L., Mulsant, B.H., & Reynolds, C.F. (2015). Longer lithium exposure is associated with better white matter integrity in older adults with bipolar disorder. Bipolar Disord, 17(3), 248-256.Wiley. doi: 10.1111/bdi.12260.
Goodheart, A.E., Tamburo, E., Minhas, D., Aizenstein, H.J., McDade, E., Snitz, B.E., Price, J.C., Mathis, C.A., Lopez, O.L., Klunk, W.E., & Cohen, A.D. (2015). Reduced binding of Pittsburgh Compound-B in areas of white matter hyperintensities. Neuroimage Clin, 9, 479-483.Elsevier. doi: 10.1016/j.nicl.2015.09.009.
Gregg, N.M., Kim, A.E., Gurol, M.E., Lopez, O.L., Aizenstein, H.J., Price, J.C., Mathis, C.A., James, J.A., Snitz, B.E., Cohen, A.D., Kamboh, M.I., Minhas, D., Weissfeld, L.A., Tamburo, E.L., & Klunk, W.E. (2015). Incidental Cerebral Microbleeds and Cerebral Blood Flow in Elderly Individuals. JAMA Neurol, 72(9), 1021-1028.American Medical Association (AMA). doi: 10.1001/jamaneurol.2015.1359.
Khalaf, A., Edelman, K., Tudorascu, D., Andreescu, C., Reynolds, C.F., & Aizenstein, H. (2015). White Matter Hyperintensity Accumulation During Treatment of Late-Life Depression. Neuropsychopharmacology, 40(13), 3027-3035.Springer Nature. doi: 10.1038/npp.2015.158.
Lee, J.H., Ryan, J., Andreescu, C., Aizenstein, H., & Lim, H.K. (2015). Brainstem morphological changes in Alzheimer's disease. Neuroreport, 26(7), 411-415.Wolters Kluwer. doi: 10.1097/WNR.0000000000000362.
Liu, G., Allen, B., Lopez, O., Aizenstein, H., Boudreau, R., Newman, A., Yaffe, K., Kritchevsky, S., Launer, L., Satterfield, S., Simonsick, E., & Rosano, C. (2015). Racial Differences in Gray Matter Integrity by Diffusion Tensor in Black and White Octogenarians. Curr Alzheimer Res, 12(7), 648-654.Bentham Science Publishers. doi: 10.2174/1567205011666141107153634.
Metti, A.L., Aizenstein, H., Yaffe, K., Boudreau, R.M., Newman, A., Launer, L., Gianaros, P.J., Lopez, O.L., Saxton, J., Ives, D.G., Kritchevsky, S., Vallejo, A.N., & Rosano, C. (2015). Trajectories of peripheral interleukin-6, structure of the hippocampus, and cognitive impairment over 14 years in older adults. Neurobiol Aging, 36(11), 3038-3044.Elsevier. doi: 10.1016/j.neurobiolaging.2015.07.025.
Mountz, J.M., Laymon, C.M., Cohen, A.D., Zhang, Z., Price, J.C., Boudhar, S., McDade, E., Aizenstein, H.J., Klunk, W.E., & Mathis, C.A. (2015). Comparison of qualitative and quantitative imaging characteristics of [11C]PiB and [18F]flutemetamol in normal control and Alzheimer's subjects. Neuroimage Clin, 9, 592-598.Elsevier. doi: 10.1016/j.nicl.2015.10.007.
Nadkarni, N.K., Perera, S., Hanlon, J.T., Lopez, O., Newman, A.B., Aizenstein, H., Elam, M., Harris, T.B., Kritchevsky, S., Yaffe, K., & Rosano, C. (2015). Statins and brain integrity in older adults: secondary analysis of the Health ABC study. Alzheimers Dement, 11(10), 1202-1211.Wiley. doi: 10.1016/j.jalz.2014.11.003.
Nadkarni, N.K., Perera, S., Studenski, S.A., Rosano, C., Aizenstein, H.J., & VanSwearingen, J.M. (2015). Callosal hyperintensities and gait speed gain from two types of mobility interventions in older adults. Arch Phys Med Rehabil, 96(6), 1154-1157.Elsevier. doi: 10.1016/j.apmr.2014.09.026.
Nunley, K.A., Rosano, C., Ryan, C.M., Jennings, J.R., Aizenstein, H.J., Zgibor, J.C., Costacou, T., Boudreau, R.M., Miller, R., Orchard, T.J., & Saxton, J.A. (2015). Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes. Diabetes Care, 38(9), 1768-1776.American Diabetes Association. doi: 10.2337/dc15-0041.
Nunley, K.A., Ryan, C.M., Orchard, T.J., Aizenstein, H.J., Jennings, J.R., Ryan, J., Zgibor, J.C., Boudreau, R.M., Costacou, T., Maynard, J.D., Miller, R.G., & Rosano, C. (2015). White matter hyperintensities in middle-aged adults with childhood-onset type 1 diabetes. Neurology, 84(20), 2062-2069.Wolters Kluwer. doi: 10.1212/WNL.0000000000001582.
Patel, M.J., Andreescu, C., Price, J.C., Edelman, K.L., Reynolds, C.F., & Aizenstein, H.J. (2015). Machine learning approaches for integrating clinical and imaging features in late-life depression classification and response prediction. Int J Geriatr Psychiatry, 30(10), 1056-1067.Wiley. doi: 10.1002/gps.4262.
Rosano, C., Abebe, K.Z., Aizenstein, H.J., Boudreau, R., Jennings, J.R., Venkatraman, V., Harris, T.B., Yaffe, K., Satterfield, S., Newman, A.B., & Health ABC Study. (2015). Longitudinal systolic blood pressure characteristics and integrity of white matter tracts in a cohort of very old black and white adults. Am J Hypertens, 28(3), 326-334.Oxford University Press (OUP). doi: 10.1093/ajh/hpu134.
Ryan, J.P., Aizenstein, H.J., Orchard, T.J., Ryan, C.M., Saxton, J.A., Fine, D.F., Nunley, K.A., & Rosano, C. (2015). Age of Childhood Onset in Type 1 Diabetes and Functional Brain Connectivity in Midlife. Psychosom Med, 77(6), 622-630.Wolters Kluwer. doi: 10.1097/PSY.0000000000000206.
Smagula, S.F., Butters, M.A., Anderson, S.J., Lenze, E.J., Dew, M.A., Mulsant, B.H., Lotrich, F.E., Aizenstein, H., & Reynolds, C.F. (2015). Antidepressant Response Trajectories and Associated Clinical Prognostic Factors Among Older Adults. JAMA Psychiatry, 72(10), 1021-1028.American Medical Association (AMA). doi: 10.1001/jamapsychiatry.2015.1324.
Snitz, B.E., Weissfeld, L.A., Cohen, A.D., Lopez, O.L., Nebes, R.D., Aizenstein, H.J., McDade, E., Price, J.C., Mathis, C.A., & Klunk, W.E. (2015). Subjective Cognitive Complaints, Personality and Brain Amyloid-beta in Cognitively Normal Older Adults. Am J Geriatr Psychiatry, 23(9), 985-993.Elsevier. doi: 10.1016/j.jagp.2015.01.008.
Thurston, R.C., Maki, P.M., Derby, C.A., Sejdić, E., & Aizenstein, H.J. (2015). Menopausal hot flashes and the default mode network. Fertil Steril, 103(6), 1572-8.e1.Elsevier. doi: 10.1016/j.fertnstert.2015.03.008.
Tian, Q., Glynn, N.W., Erickson, K.I., Aizenstein, H.J., Simonsick, E.M., Yaffe, K., Harris, T.B., Kritchevsky, S.B., Boudreau, R.M., Newman, A.B., Lopez, O.L., Saxton, J., Rosano, C., & Health ABC Study. (2015). Objective measures of physical activity, white matter integrity and cognitive status in adults over age 80. Behav Brain Res, 284, 51-57.Elsevier. doi: 10.1016/j.bbr.2015.01.045.
Vanyukov, P.M., Szanto, K., Siegle, G.J., Hallquist, M.N., Reynolds, C.F., Aizenstein, H.J., & Dombrovski, A.Y. (2015). Impulsive traits and unplanned suicide attempts predict exaggerated prefrontal response to angry faces in the elderly. Am J Geriatr Psychiatry, 23(8), 829-839.Elsevier. doi: 10.1016/j.jagp.2014.10.004.
Yau, W.Y.W., Tudorascu, D.L., McDade, E.M., Ikonomovic, S., James, J.A., Minhas, D., Mowrey, W., Sheu, L.K., Snitz, B.E., Weissfeld, L., Gianaros, P.J., Aizenstein, H.J., Price, J.C., Mathis, C.A., Lopez, O.L., & Klunk, W.E. (2015). Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: a prospective cohort study. Lancet Neurol, 14(8), 804-813.Elsevier. doi: 10.1016/S1474-4422(15)00135-0.
Aizenstein, H.J., Khalaf, A., Walker, S.E., & Andreescu, C. (2014). Magnetic resonance imaging predictors of treatment response in late-life depression. J Geriatr Psychiatry Neurol, 27(1), 24-32.SAGE Publications. doi: 10.1177/0891988713516541.
Andreescu, C., Sheu, L.K., Tudorascu, D., Walker, S., & Aizenstein, H. (2014). The ages of anxiety--differences across the lifespan in the default mode network functional connectivity in generalized anxiety disorder. Int J Geriatr Psychiatry, 29(7), 704-712.Wiley. doi: 10.1002/gps.4051.
Bolandzadeh, N., Liu-Ambrose, T., Aizenstein, H., Harris, T., Launer, L., Yaffe, K., Kritchevsky, S.B., Newman, A., & Rosano, C. (2014). Pathways linking regional hyperintensities in the brain and slower gait. Neuroimage, 99, 7-13.Elsevier. doi: 10.1016/j.neuroimage.2014.05.017.
Diniz, B.S., Reynolds, C.F., Begley, A., Dew, M.A., Anderson, S.J., Lotrich, F., Erickson, K.I., Lopez, O., Aizenstein, H., Sibille, E.L., & Butters, M.A. (2014). Brain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: a longitudinal study. J Psychiatr Res, 49(1), 96-101.Elsevier. doi: 10.1016/j.jpsychires.2013.11.004.
Gildengers, A.G., Chung, K.H., Huang, S.H., Begley, A., Aizenstein, H.J., & Tsai, S.Y. (2014). Neuroprogressive effects of lifetime illness duration in older adults with bipolar disorder. Bipolar Disord, 16(6), 617-623.Wiley. doi: 10.1111/bdi.12204.
Karim, H.T., Sparto, P.J., Aizenstein, H.J., Furman, J.M., Huppert, T.J., Erickson, K.I., & Loughlin, P.J. (2014). Functional MR imaging of a simulated balance task. Brain Res, 1555, 20-27.Elsevier. doi: 10.1016/j.brainres.2014.01.033.
Lim, H.K., & Aizenstein, H.J. (2014). Recent findings and newer paradigms of neuroimaging research in geriatric psychiatry. J Geriatr Psychiatry Neurol, 27(1), 3-4.SAGE Publications. doi: 10.1177/0891988713516538.
Lim, H.K., Nebes, R., Snitz, B., Cohen, A., Mathis, C., Price, J., Weissfeld, L., Klunk, W., & Aizenstein, H.J. (2014). Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects. Brain, 137(Pt 12), 3327-3338.Oxford University Press (OUP). doi: 10.1093/brain/awu271.
Lopez, O.L., Klunk, W.E., Mathis, C., Coleman, R.L., Price, J., Becker, J.T., Aizenstein, H.J., Snitz, B., Cohen, A., Ikonomovic, M., McDade, E., DeKosky, S.T., Weissfeld, L., & Kuller, L.H. (2014). Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old. Neurology, 83(20), 1804-1811.Wolters Kluwer. doi: 10.1212/WNL.0000000000000977.
Lotrich, F.E., Butters, M.A., Aizenstein, H., Marron, M.M., Reynolds, C.F., & Gildengers, A.G. (2014). The relationship between interleukin-1 receptor antagonist and cognitive function in older adults with bipolar disorder. Int J Geriatr Psychiatry, 29(6), 635-644.Wiley. doi: 10.1002/gps.4048.
Nadkarni, N.K., Nunley, K.A., Aizenstein, H., Harris, T.B., Yaffe, K., Satterfield, S., Newman, A.B., Rosano, C., & Health ABC Study. (2014). Association between cerebellar gray matter volumes, gait speed, and information-processing ability in older adults enrolled in the Health ABC study. J Gerontol A Biol Sci Med Sci, 69(8), 996-1003.Oxford University Press (OUP). doi: 10.1093/gerona/glt151.
Olson Hunt, M.J., Weissfeld, L., Boudreau, R.M., Aizenstein, H., Newman, A.B., Simonsick, E.M., Van Domelen, D.R., Thomas, F., Yaffe, K., & Rosano, C. (2014). A variant of sparse partial least squares for variable selection and data exploration. Front Neuroinform, 8(MAR), 18.Frontiers. doi: 10.3389/fninf.2014.00018.
Rej, S., Butters, M.A., Aizenstein, H.J., Begley, A., Tsay, J., Reynolds, C.F., Mulsant, B.H., & Gildengers, A. (2014). Neuroimaging and neurocognitive abnormalities associated with bipolar disorder in old age. Int J Geriatr Psychiatry, 29(4), 421-427.Wiley. doi: 10.1002/gps.4021.
Rosso, A.L., Olson Hunt, M.J., Yang, M., Brach, J.S., Harris, T.B., Newman, A.B., Satterfield, S., Studenski, S.A., Yaffe, K., Aizenstein, H.J., Rosano, C., & Health ABC study. (2014). Higher step length variability indicates lower gray matter integrity of selected regions in older adults. Gait Posture, 40(1), 225-230.Elsevier. doi: 10.1016/j.gaitpost.2014.03.192.
Tian, Q., Erickson, K.I., Simonsick, E.M., Aizenstein, H.J., Glynn, N.W., Boudreau, R.M., Newman, A.B., Kritchevsky, S.B., Yaffe, K., Harris, T.B., & Rosano, C. (2014). Physical activity predicts microstructural integrity in memory-related networks in very old adults. J Gerontol A Biol Sci Med Sci, 69(10), 1284-1290.Oxford University Press (OUP). doi: 10.1093/gerona/glt287.
Tian, Q., Simonsick, E.M., Erickson, K.I., Aizenstein, H.J., Glynn, N.W., Boudreau, R.M., Newman, A.B., Kritchevsky, S.B., Yaffe, K., Harris, T., Rosano, C., & Health ABC study. (2014). Cardiorespiratory fitness and brain diffusion tensor imaging in adults over 80 years of age. Brain Res, 1588, 63-72.Elsevier. doi: 10.1016/j.brainres.2014.09.003.
Tudorascu, D.L., Rosano, C., Venkatraman, V.K., MacCloud, R.L., Harris, T., Yaffe, K., Newman, A.B., & Aizenstein, H.J. (2014). Multimodal MRI markers support a model of small vessel ischemia for depressive symptoms in very old adults. Psychiatry Res, 224(2), 73-80.Elsevier. doi: 10.1016/j.pscychresns.2014.08.009.
Almeida, J.R.C., Mourao-Miranda, J., Aizenstein, H.J., Versace, A., Kozel, F.A., Lu, H., Marquand, A., LaBarbara, E.J., Brammer, M., Trivedi, M., Kupfer, D.J., & Phillips, M.L. (2013). Pattern recognition analysis of anterior cingulate cortex blood flow to classify depression polarity. Br J Psychiatry, 203(3), 310-311.Royal College of Psychiatrists. doi: 10.1192/bjp.bp.112.122838.
Andreescu, C., Tudorascu, D.L., Butters, M.A., Tamburo, E., Patel, M., Price, J., Karp, J.F., Reynolds, C.F., & Aizenstein, H. (2013). Resting state functional connectivity and treatment response in late-life depression. Psychiatry Res, 214(3), 313-321.Elsevier. doi: 10.1016/j.pscychresns.2013.08.007.
Buckalew, N., Haut, M.W., Aizenstein, H., Rosano, C., Edelman, K.D., Perera, S., Marrow, L., Tadic, S., Venkatraman, V., & Weiner, D. (2013). White matter hyperintensity burden and disability in older adults: is chronic pain a contributor?. PM R, 5(6), 471-480.Wiley. doi: 10.1016/j.pmrj.2013.03.004.
Cohen, A.D., Mowrey, W., Weissfeld, L.A., Aizenstein, H.J., McDade, E., Mountz, J.M., Nebes, R.D., Saxton, J.A., Snitz, B., Dekosky, S., Williamson, J., Lopez, O.L., Price, J.C., Mathis, C.A., & Klunk, W.E. (2013). Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches. Neuroimage, 71, 207-215.Elsevier. doi: 10.1016/j.neuroimage.2013.01.015.
Erickson, K.I., Barr, L.L., Weinstein, A.M., Banducci, S.E., Akl, S.L., Santo, N.M., Leckie, R.L., Oakley, M., Saxton, J., Aizenstein, H.J., Becker, J.T., & Lopez, O.L. (2013). Measuring physical activity using accelerometry in a community sample with dementia. J Am Geriatr Soc, 61(1), 158-159.Wiley. doi: 10.1111/jgs.12050.
Hughes, T.M., Kuller, L.H., Barinas-Mitchell, E.J.M., Mackey, R.H., McDade, E.M., Klunk, W.E., Aizenstein, H.J., Cohen, A.D., Snitz, B.E., Mathis, C.A., Dekosky, S.T., & Lopez, O.L. (2013). Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults. Neurology, 81(19), 1711-1718.Wolters Kluwer. doi: 10.1212/01.wnl.0000435301.64776.37.
Hughes, T.M., Ryan, C.M., Aizenstein, H.J., Nunley, K., Gianaros, P.J., Miller, R., Costacou, T., Strotmeyer, E.S., Orchard, T.J., & Rosano, C. (2013). Frontal gray matter atrophy in middle aged adults with type 1 diabetes is independent of cardiovascular risk factors and diabetes complications. J Diabetes Complications, 27(6), 558-564.Elsevier. doi: 10.1016/j.jdiacomp.2013.07.001.
Khandai, A.C., & Aizenstein, H.J. (2013). Recent advances in neuroimaging biomarkers in geriatric psychiatry. Curr Psychiatry Rep, 15(6), 360.Springer Nature. doi: 10.1007/s11920-013-0360-9.
Lim, H.K., Jung, W.S., & Aizenstein, H.J. (2013). Aberrant topographical organization in gray matter structural network in late life depression: a graph theoretical analysis. Int Psychogeriatr, 25(12), 1929-1940.Elsevier. doi: 10.1017/S104161021300149X.
Lopez, O.L., Becker, J.T., Chang, Y.F., Sweet, R.A., Aizenstein, H., Snitz, B., Saxton, J., McDade, E., Kamboh, M.I., DeKosky, S.T., Reynolds, C.F., & Klunk, W.E. (2013). The long-term effects of conventional and atypical antipsychotics in patients with probable Alzheimer's disease. Am J Psychiatry, 170(9), 1051-1058.American Psychiatric Association Publishing. doi: 10.1176/appi.ajp.2013.12081046.
Mathis, C.A., Kuller, L.H., Klunk, W.E., Snitz, B.E., Price, J.C., Weissfeld, L.A., Rosario, B.L., Lopresti, B.J., Saxton, J.A., Aizenstein, H.J., McDade, E.M., Kamboh, M.I., DeKosky, S.T., & Lopez, O.L. (2013). In vivo assessment of amyloid-β deposition in nondemented very elderly subjects. Ann Neurol, 73(6), 751-761.Wiley. doi: 10.1002/ana.23797.
Nadkarni, N.K., Studenski, S.A., Perera, S., Rosano, C., Aizenstein, H.J., Brach, J.S., & Van Swearingen, J.M. (2013). White matter hyperintensities, exercise, and improvement in gait speed: does type of gait rehabilitation matter?. J Am Geriatr Soc, 61(5), 686-693.Wiley. doi: 10.1111/jgs.12211.
Nebes, R.D., Snitz, B.E., Cohen, A.D., Aizenstein, H.J., Saxton, J.A., Halligan, E.M., Mathis, C.A., Price, J.C., Kamboh, M.I., Weissfeld, L.A., & Klunk, W.E. (2013). Cognitive aging in persons with minimal amyloid-β and white matter hyperintensities. Neuropsychologia, 51(11), 2202-2209.Elsevier. doi: 10.1016/j.neuropsychologia.2013.07.017.
Reder, L.M., Victoria, L.W., Manelis, A., Oates, J.M., Dutcher, J.M., Bates, J.T., Cook, S., Aizenstein, H.J., Quinlan, J., & Gyulai, F. (2013). Why it's easier to remember seeing a face we already know than one we don't: preexisting memory representations facilitate memory formation. Psychol Sci, 24(3), 363-372.SAGE Publications. doi: 10.1177/0956797612457396.
Rosano, C., Chang, Y.F., Kuller, L.H., Guralnik, J.M., Studenski, S.A., Aizenstein, H.J., Gianaros, P.J., Lopez, O.L., Longstreth, W.T., & Newman, A.B. (2013). Long-term survival in adults 65 years and older with white matter hyperintensity: association with performance on the digit symbol substitution test. Psychosom Med, 75(7), 624-631.Wolters Kluwer. doi: 10.1097/PSY.0b013e31829c1df2.
Rosano, C., Watson, N., Chang, Y., Newman, A.B., Aizenstein, H.J., Du, Y., Venkatraman, V., Harris, T.B., Barinas-Mitchell, E., & Sutton-Tyrrell, K. (2013). Aortic pulse wave velocity predicts focal white matter hyperintensities in a biracial cohort of older adults. Hypertension, 61(1), 160-165.Wolters Kluwer. doi: 10.1161/HYPERTENSIONAHA.112.198069.
Rosso, A.L., Studenski, S.A., Chen, W.G., Aizenstein, H.J., Alexander, N.B., Bennett, D.A., Black, S.E., Camicioli, R., Carlson, M.C., Ferrucci, L., Guralnik, J.M., Hausdorff, J.M., Kaye, J., Launer, L.J., Lipsitz, L.A., Verghese, J., & Rosano, C. (2013). Aging, the central nervous system, and mobility. J Gerontol A Biol Sci Med Sci, 68(11), 1379-1386.Oxford University Press (OUP). doi: 10.1093/gerona/glt089.
Roush, R. (2013). Dance, Dance Revolution: Change in Executive Function Following a Video Dance Intervention in Postmenopausal Women. University of Pittsburgh.
Taylor, W.D., Aizenstein, H.J., & Alexopoulos, G.S. (2013). The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry, 18(9), 963-974.Springer Nature. doi: 10.1038/mp.2013.20.
Vu, N.Q., & Aizenstein, H.J. (2013). Depression in the elderly: brain correlates, neuropsychological findings, and role of vascular lesion load. Curr Opin Neurol, 26(6), 656-661.Wolters Kluwer. doi: 10.1097/WCO.0000000000000028.
Andreescu, C., & Aizenstein, H. (2012). MRI studies in late-life mood disorders. Curr Top Behav Neurosci, 11, 269-287.Springer Nature. doi: 10.1007/7854_2011_175.
Becker, J.T., Bajo, R., Fabrizio, M., Sudre, G., Cuesta, P., Aizenstein, H.J., Lopez, O.L., Wolk, D., Parkkonen, L., Maestu, F., & Bagic, A. (2012). Functional connectivity measured with magnetoencephalography identifies persons with HIV disease. Brain Imaging Behav, 6(3), 366-373.Springer Nature. doi: 10.1007/s11682-012-9149-4.
Becker, J.T., Dew, M.A., Aizenstein, H.J., Lopez, O.L., Morrow, L., Saxton, J., & Tárraga, L. (2012). A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV disease. Disabil Rehabil, 34(21), 1848-1852.Taylor & Francis. doi: 10.3109/09638288.2012.667188.
Becker, J.T., Fabrizio, M., Sudre, G., Haridis, A., Ambrose, T., Aizenstein, H.J., Eddy, W., Lopez, O.L., Wolk, D.A., Parkkonen, L., & Bagic, A. (2012). Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease. J Neurosci Methods, 206(2), 176-182.Elsevier. doi: 10.1016/j.jneumeth.2012.02.022.
Dombrovski, A.Y., Siegle, G.J., Szanto, K., Clark, L., Reynolds, C.F., & Aizenstein, H. (2012). The temptation of suicide: striatal gray matter, discounting of delayed rewards, and suicide attempts in late-life depression. Psychol Med, 42(6), 1203-1215.Cambridge University Press (CUP). doi: 10.1017/S0033291711002133.
Jennings, J.R., Mendelson, D.N., Muldoon, M.F., Ryan, C.M., Gianaros, P.J., Raz, N., & Aizenstein, H. (2012). Regional grey matter shrinks in hypertensive individuals despite successful lowering of blood pressure. J Hum Hypertens, 26(5), 295-305.Springer Nature. doi: 10.1038/jhh.2011.31.
Liang, P., Manelis, A., Liu, X., Aizenstein, H.J., Gyulai, F., Quinlan, J.J., & Reder, L.M. (2012). Using arterial spin labeling perfusion MRI to explore how midazolam produces anterograde amnesia. Neurosci Lett, 522(2), 113-117.Elsevier. doi: 10.1016/j.neulet.2012.06.019.
Patel, M.J., Boada, F.E., Price, J.C., Sheu, L.K., Tudorascu, D.L., Reynolds Iii, C.F., & Aizenstein, H.J. (2012). Association of small vessel ischemic white matter changes with BOLD fMRI imaging in the elderly. Psychiatry Res, 204(2-3), 117-122.Elsevier. doi: 10.1016/j.pscychresns.2012.09.006.
Rosano, C., Aizenstein, H.J., Newman, A.B., Venkatraman, V., Harris, T., Ding, J., Satterfield, S., Yaffe, K., & Health ABC Study. (2012). Neuroimaging differences between older adults with maintained versus declining cognition over a 10-year period. Neuroimage, 62(1), 307-313.Elsevier. doi: 10.1016/j.neuroimage.2012.04.033.
Rosano, C., Bennett, D.A., Newman, A.B., Venkatraman, V., Yaffe, K., Harris, T., Kritchevsky, S., & Aizenstein, H.J. (2012). Patterns of focal gray matter atrophy are associated with bradykinesia and gait disturbances in older adults. J Gerontol A Biol Sci Med Sci, 67(9), 957-962.Oxford University Press (OUP). doi: 10.1093/gerona/glr262.
Rosano, C., Studenski, S.A., Aizenstein, H.J., Boudreau, R.M., Longstreth, W.T., & Newman, A.B. (2012). Slower gait, slower information processing and smaller prefrontal area in older adults. Age Ageing, 41(1), 58-64.Oxford University Press (OUP). doi: 10.1093/ageing/afr113.
Tamburo, R., Becker, J., Siegle, G., Butters, M., Reynolds, C., & Aizenstein, H.J. (2012). The Effects of Amygdalar Size Normalization on Group Analysis in Late-Life Depression.
Teverovsky, L., Becker, J.T., Aizenstein, H.J., Carmichael, O.T., Meltzer, C.C., DeKosky, S.T., Kuller, L., Lopez, O.L., Thompson, P.M., & Liu, Y. (2012). QUANTIFICATION OF NORMAL BRAIN AGING USING FULLY DEFORMABLE REGISTRATION.
Aizenstein, H.J., Andreescu, C., Edelman, K.L., Cochran, J.L., Price, J., Butters, M.A., Karp, J., Patel, M., & Reynolds, C.F. (2011). fMRI correlates of white matter hyperintensities in late-life depression. Am J Psychiatry, 168(10), 1075-1082.American Psychiatric Association Publishing. doi: 10.1176/appi.ajp.2011.10060853.
Andreescu, C., Gross, J.J., Lenze, E., Edelman, K.D., Snyder, S., Tanase, C., & Aizenstein, H. (2011). Altered cerebral blood flow patterns associated with pathologic worry in the elderly. Depress Anxiety, 28(3), 202-209.Hindawi. doi: 10.1002/da.20799.
Andreescu, C., Wu, M., Butters, M.A., Figurski, J., Reynolds, C.F., & Aizenstein, H.J. (2011). The default mode network in late-life anxious depression. Am J Geriatr Psychiatry, 19(11), 980-983.Elsevier. doi: 10.1097/JGP.0b013e318227f4f9.
Becker, J.T., Dew, M.A., Aizenstein, H.J., Lopez, O.L., Morrow, L., & Saxton, J. (2011). Concurrent validity of a computer-based cognitive screening tool for use in adults with HIV disease. AIDS Patient Care STDS, 25(6), 351-357.SAGE Publications. doi: 10.1089/apc.2011.0051.
Venkatraman, V.K., Aizenstein, H.J., Newman, A.B., Yaffe, K., Harris, T., Kritchevsky, S., Ayonayon, H.N., & Rosano, C. (2011). Lower Digit Symbol Substitution Score in the Oldest Old is Related to Magnetization Transfer and Diffusion Tensor Imaging of the White Matter. Front Aging Neurosci, 3(SEP), 11.Frontiers. doi: 10.3389/fnagi.2011.00011.
Whyte, E., Skidmore, E., Aizenstein, H., Ricker, J., & Butters, M. (2011). Cognitive impairment in acquired brain injury: a predictor of rehabilitation outcomes and an opportunity for novel interventions. PM R, 3(6 Suppl 1), S45-S51.Wiley. doi: 10.1016/j.pmrj.2011.05.007.
Wolk, D.A., Dunfee, K.L., Dickerson, B.C., Aizenstein, H.J., & DeKosky, S.T. (2011). A medial temporal lobe division of labor: insights from memory in aging and early Alzheimer disease. Hippocampus, 21(5), 461-466.Wiley. doi: 10.1002/hipo.20779.
Womack, K.B., Diaz-Arrastia, R., Aizenstein, H.J., Arnold, S.E., Barbas, N.R., Boeve, B.F., Clark, C.M., DeCarli, C.S., Jagust, W.J., Leverenz, J.B., Peskind, E.R., Turner, R.S., Zamrini, E.Y., Heidebrink, J.L., Burke, J.R., DeKosky, S.T., Farlow, M.R., Gabel, M.J., Higdon, R., Kawas, C.H., Koeppe, R.A., Lipton, A.M., & Foster, N.L. (2011). Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors. Arch Neurol, 68(3), 329-337.American Medical Association (AMA). doi: 10.1001/archneurol.2010.295.
Wu, M., Andreescu, C., Butters, M.A., Tamburo, R., Reynolds, C.F., & Aizenstein, H. (2011). Default-mode network connectivity and white matter burden in late-life depression. Psychiatry Res, 194(1), 39-46.Elsevier. doi: 10.1016/j.pscychresns.2011.04.003.
Aizenstein, H., & Venkatraman, V. (2010). Magnetic Resonance Imaging and Computed Tomography. In Principles and Practice of Geriatric Psychiatry. (pp. 433-436).Wiley. doi: 10.1002/9780470669600.ch69.
Buckalew, N., Haut, M.W., Aizenstein, H., Morrow, L., Perera, S., Kuwabara, H., & Weiner, D.K. (2010). Differences in brain structure and function in older adults with self-reported disabling and nondisabling chronic low back pain. Pain Med, 11(8), 1183-1197.Oxford University Press (OUP). doi: 10.1111/j.1526-4637.2010.00899.x.
Cornelius, J.R., Aizenstein, H.J., & Hariri, A.R. (2010). Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression. Addict Behav, 35(6), 644-646.Elsevier. doi: 10.1016/j.addbeh.2010.02.004.
Gabel, M.J., Foster, N.L., Heidebrink, J.L., Higdon, R., Aizenstein, H.J., Arnold, S.E., Barbas, N.R., Boeve, B.F., Burke, J.R., Clark, C.M., Dekosky, S.T., Farlow, M.R., Jagust, W.J., Kawas, C.H., Koeppe, R.A., Leverenz, J.B., Lipton, A.M., Peskind, E.R., Turner, R.S., Womack, K.B., & Zamrini, E.Y. (2010). Validation of consensus panel diagnosis in dementia. Arch Neurol, 67(12), 1506-1512.American Medical Association (AMA). doi: 10.1001/archneurol.2010.301.
Rosano, C., Venkatraman, V.K., Guralnik, J., Newman, A.B., Glynn, N.W., Launer, L., Taylor, C.A., Williamson, J., Studenski, S., Pahor, M., & Aizenstein, H. (2010). Psychomotor speed and functional brain MRI 2 years after completing a physical activity treatment. J Gerontol A Biol Sci Med Sci, 65(6), 639-647.Oxford University Press (OUP). doi: 10.1093/gerona/glq038.
Tadic, S.D., Griffiths, D., Murrin, A., Schaefer, W., Aizenstein, H.J., & Resnick, N.M. (2010). Brain activity during bladder filling is related to white matter structural changes in older women with urinary incontinence. Neuroimage, 51(4), 1294-1302.Elsevier. doi: 10.1016/j.neuroimage.2010.03.016.
Venkatraman, V.K., Aizenstein, H., Guralnik, J., Newman, A.B., Glynn, N.W., Taylor, C., Studenski, S., Launer, L., Pahor, M., Williamson, J., & Rosano, C. (2010). Executive control function, brain activation and white matter hyperintensities in older adults. Neuroimage, 49(4), 3436-3442.Elsevier. doi: 10.1016/j.neuroimage.2009.11.019.
Venkatraman, V.K., Aizenstein, H., Guralnik, J., Newman, A.B., Glynn, N.W., Taylor, C., Studenski, S., Launer, L., Pahor, M., Williamson, J., & Rosano, C. (2010). Executive control function, brain activation and white matter hyperintensities in older adults (vol 49, pg 3436, 2010). NEUROIMAGE, 50(4), 1711.Elsevier. doi: 10.1016/j.neuroimage.2010.01.074.
Wagner, A., Aizenstein, H., Venkatraman, V.K., Bischoff-Grethe, A., Fudge, J., May, J.C., Frank, G.K., Bailer, U.F., Fischer, L., Putnam, K., & Kaye, W.H. (2010). Altered striatal response to reward in bulimia nervosa after recovery. Int J Eat Disord, 43(4), 289-294.Wiley. doi: 10.1002/eat.20699.
Wang, Y., Zhang, J., Gutman, B., Chan, T.F., Becker, J.T., Aizenstein, H.J., Lopez, O.L., Tamburo, R.J., Toga, A.W., & Thompson, P.M. (2010). Multivariate tensor-based morphometry on surfaces: application to mapping ventricular abnormalities in HIV/AIDS. Neuroimage, 49(3), 2141-2157.Elsevier. doi: 10.1016/j.neuroimage.2009.10.086.
Willford, J., Day, R., Aizenstein, H., & Day, N. (2010). Caudate asymmetry: a neurobiological marker of moderate prenatal alcohol exposure in young adults. Neurotoxicol Teratol, 32(6), 589-594.Elsevier. doi: 10.1016/j.ntt.2010.06.012.
Aizenstein, H.J., Butters, M.A., Wu, M., Mazurkewicz, L.M., Stenger, V.A., Gianaros, P.J., Becker, J.T., Reynolds, C.F., & Carter, C.S. (2009). Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena. Am J Geriatr Psychiatry, 17(1), 30-42.Elsevier. doi: 10.1097/JGP.0b013e31817b60af.
Andreescu, C., Butters, M., Lenze, E.J., Venkatraman, V.K., Nable, M., Reynolds, C.F., & Aizenstein, H.J. (2009). fMRI activation in late-life anxious depression: a potential biomarker. Int J Geriatr Psychiatry, 24(8), 820-828.Wiley. doi: 10.1002/gps.2327.
Bhalla, R.K., Butters, M.A., Becker, J.T., Houck, P.R., Snitz, B.E., Lopez, O.L., Aizenstein, H.J., Raina, K.D., DeKosky, S.T., & Reynolds, C.F. (2009). Patterns of mild cognitive impairment after treatment of depression in the elderly. Am J Geriatr Psychiatry, 17(4), 308-316.Elsevier. doi: 10.1097/JGP.0b013e318190b8d8.
Butters, M.A., Aizenstein, H.J., Hayashi, K.M., Meltzer, C.C., Seaman, J., Reynolds, C.F., Toga, A.W., Thompson, P.M., Becker, J.T., & IMAGe Research Group. (2009). Three-dimensional surface mapping of the caudate nucleus in late-life depression. Am J Geriatr Psychiatry, 17(1), 4-12.Elsevier. doi: 10.1097/JGP.0b013e31816ff72b.
Cohen, A.D., Price, J.C., Weissfeld, L.A., James, J., Rosario, B.L., Bi, W., Nebes, R.D., Saxton, J.A., Snitz, B.E., Aizenstein, H.A., Wolk, D.A., Dekosky, S.T., Mathis, C.A., & Klunk, W.E. (2009). Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve. J Neurosci, 29(47), 14770-14778.Society for Neuroscience. doi: 10.1523/JNEUROSCI.3669-09.2009.
Soreca, I., Rosano, C., Jennings, J.R., Sheu, L.K., Kuller, L.H., Matthews, K.A., Aizenstein, H.J., & Gianaros, P.J. (2009). Gain in adiposity across 15 years is associated with reduced gray matter volume in healthy women. Psychosom Med, 71(5), 485-490.Wolters Kluwer. doi: 10.1097/PSY.0b013e3181a5429d.
Tamburo, R.J., Siegle, G.J., Stetten, G.D., Cois, C.A., Butters, M.A., Reynolds, C.F., & Aizenstein, H.J. (2009). Amygdalae morphometry in late-life depression. Int J Geriatr Psychiatry, 24(8), 837-846.Wiley. doi: 10.1002/gps.2167.
Ursu, S., Clark, K.A., Aizenstein, H.J., Stenger, V.A., & Carter, C.S. (2009). Conflict-related activity in the caudal anterior cingulate cortex in the absence of awareness. Biol Psychol, 80(3), 279-286.Elsevier. doi: 10.1016/j.biopsycho.2008.10.008.
Wolk, D.A., Price, J.C., Saxton, J.A., Snitz, B.E., James, J.A., Lopez, O.L., Aizenstein, H.J., Cohen, A.D., Weissfeld, L.A., Mathis, C.A., Klunk, W.E., & De-Kosky, S.T. (2009). Amyloid imaging in mild cognitive impairment subtypes. Ann Neurol, 65(5), 557-568.Wiley. doi: 10.1002/ana.21598.
Aizenstein, H.J., Nebes, R.D., Saxton, J.A., Price, J.C., Mathis, C.A., Tsopelas, N.D., Ziolko, S.K., James, J.A., Snitz, B.E., Houck, P.R., Bi, W., Cohen, A.D., Lopresti, B.J., DeKosky, S.T., Halligan, E.M., & Klunk, W.E. (2008). Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol, 65(11), 1509-1517.American Medical Association (AMA). doi: 10.1001/archneur.65.11.1509.
Andreescu, C., Butters, M.A., Begley, A., Rajji, T., Wu, M., Meltzer, C.C., Reynolds, C.F., & Aizenstein, H. (2008). Gray matter changes in late life depression--a structural MRI analysis. Neuropsychopharmacology, 33(11), 2566-2572.Springer Nature. doi: 10.1038/sj.npp.1301655.
Bigos, K.L., Pollock, B.G., Aizenstein, H.J., Fisher, P.M., Bies, R.R., & Hariri, A.R. (2008). Acute 5-HT reuptake blockade potentiates human amygdala reactivity. Neuropsychopharmacology, 33(13), 3221-3225.Springer Nature. doi: 10.1038/npp.2008.52.
Butters, M.A., Young, J.B., Lopez, O., Aizenstein, H.J., Mulsant, B.H., Reynolds, C.F., DeKosky, S.T., & Becker, J.T. (2008). Pathways linking late-life depression to persistent cognitive impairment and dementia. Dialogues Clin Neurosci, 10(3), 345-357.Taylor & Francis. doi: 10.31887/DCNS.2008.10.3/mabutters.
Cox, K.M., Aizenstein, H.J., & Fiez, J.A. (2008). Striatal outcome processing in healthy aging. Cogn Affect Behav Neurosci, 8(3), 304-317.Springer Nature. doi: 10.3758/cabn.8.3.304.
Klunder, A.D., Chiang, M.C., Dutton, R.A., Lee, S.E., Toga, A.W., Lopez, O.L., Aizenstein, H.J., Becker, J.T., & Thompson, P.M. (2008). Mapping cerebellar degeneration in HIV/AIDS. Neuroreport, 19(17), 1655-1659.Wolters Kluwer. doi: 10.1097/WNR.0b013e328311d374.
Kumar, A., Aizenstein, H., & Ballmaier, M. (2008). Multimodal neuroimaging in late-life mental disorders: entering a more mature phase of clinical neuroscience research. Am J Geriatr Psychiatry, 16(4), 251-254.Elsevier. doi: 10.1097/JGP.0b013e31816721e9.
Lepore, N., Brun, C., Chou, Y.Y., Chiang, M.C., Dutton, R.A., Hayashi, K.M., Luders, E., Lopez, O.L., Aizenstein, H.J., Toga, A.W., Becker, J.T., & Thompson, P.M. (2008). Generalized tensor-based morphometry of HIV/AIDS using multivariate statistics on deformation tensors. IEEE Trans Med Imaging, 27(1), 129-141.Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/TMI.2007.906091.
Rosano, C., Aizenstein, H., Brach, J., Longenberger, A., Studenski, S., & Newman, A.B. (2008). Gait Measures Indicate Underlying Focal Gray Matter Atrophy in the Brain of Older Adults. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 63(12), 1380-1388.Oxford University Press (OUP). doi: 10.1093/gerona/63.12.1380.
Sparto, P.J., Aizenstein, H.J., Vanswearingen, J.M., Rosano, C., Perera, S., Studenski, S.A., Furman, J.M., & Redfern, M.S. (2008). Delays in auditory-cued step initiation are related to increased volume of white matter hyperintensities in older adults. Exp Brain Res, 188(4), 633-640.Springer Nature. doi: 10.1007/s00221-008-1443-4.
Wagner, A., Aizenstein, H., Mazurkewicz, L., Fudge, J., Frank, G.K., Putnam, K., Bailer, U.F., Fischer, L., & Kaye, W.H. (2008). Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa. Neuropsychopharmacology, 33(3), 513-523.Springer Nature. doi: 10.1038/sj.npp.1301443.
Alcantara, D., Carmichael, O., Delson, E., Harcourt-Smith, W., Sterner, K., Frost, S., Dutton, R., Thompson, P., Aizenstein, H., Lopez, O., Becker, J., & Amenta, N. (2007). Localized components analysis. Inf Process Med Imaging, 20, 519-531.Springer Nature. doi: 10.1007/978-3-540-73273-0_43.
Alcantara, D., Carmichael, O., Delson, E., Harcourt-Smith, W., Sterner, K., Frost, S., Dutton, R., Thompson, P., Aizenstein, H., Lopez, O., Becker, J., & Amenta, N. (2007). Localized components analysis. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 4584 LNCS, 519-531. doi: 10.1007/978-3-540-73273-0_43.
Carmichael, O.T., Kuller, L.H., Lopez, O.L., Thompson, P.M., Dutton, R.A., Lu, A., Lee, S.E., Lee, J.Y., Aizenstein, H.J., Meltzer, C.C., Liu, Y., Toga, A.W., & Becker, J.T. (2007). Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study. Neurobiol Aging, 28(9), 1316-1321.Elsevier. doi: 10.1016/j.neurobiolaging.2006.06.016.
Carmichael, O.T., Kuller, L.H., Lopez, O.L., Thompson, P.M., Dutton, R.A., Lu, A., Lee, S.E., Lee, J.Y., Aizenstein, H.J., Meltzer, C.C., Liu, Y., Toga, A.W., & Becker, J.T. (2007). Ventricular volume and dementia progression in the Cardiovascular Health Study. Neurobiol Aging, 28(3), 389-397.Elsevier. doi: 10.1016/j.neurobiolaging.2006.01.006.
Carmichael, O.T., Kuller, L.H., Lopez, O.L., Thompson, P.M., Dutton, R.A., Lu, A., Lee, S.E., Lee, J.Y., Aizenstein, H.J., Meltzer, C.C., Liu, Y., Toga, A.W., & Becker, J.T. (2007). Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia. Alzheimer Dis Assoc Disord, 21(1), 14-24.Wolters Kluwer. doi: 10.1097/WAD.0b013e318032d2b1.
Chiang, M.C., Dutton, R.A., Hayashi, K.M., Lopez, O.L., Aizenstein, H.J., Toga, A.W., Becker, J.T., & Thompson, P.M. (2007). 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry. Neuroimage, 34(1), 44-60.Elsevier. doi: 10.1016/j.neuroimage.2006.08.030.
Juengst, S.B., Aizenstein, H.J., Figurski, J., Lopez, O.L., & Becker, J.T. (2007). Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjects. J Neurosci Methods, 163(2), 208-212.Elsevier. doi: 10.1016/j.jneumeth.2007.03.004.
Klunk, W.E., Price, J.C., Mathis, C.A., Tsopelas, N.D., Lopresti, B.J., Ziolko, S.K., Bi, W., Hoge, J.A., Cohen, A.D., Ikonomovic, M.D., Saxton, J.A., Snitz, B.E., Pollen, D.A., Moonis, M., Lippa, C.F., Swearer, J.M., Johnson, K.A., Rentz, D.M., Fischman, A.J., Aizenstein, H.J., & DeKosky, S.T. (2007). Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees. J Neurosci, 27(23), 6174-6184.Society for Neuroscience. doi: 10.1523/JNEUROSCI.0730-07.2007.
Leporé, N., Brun, C., Pennec, X., Chou, Y.Y., Lopez, O.L., Aizenstein, H.J., Becker, J.T., Toga, A.W., & Thompson, P.M. (2007). Mean template for tensor-based morphometry using deformation tensors. Med Image Comput Comput Assist Interv, 10(Pt 2), 826-833.Springer Nature. doi: 10.1007/978-3-540-75759-7_100.
Rosano, C., Aizenstein, H.J., Studenski, S., & Newman, A.B. (2007). A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adults. J Gerontol A Biol Sci Med Sci, 62(9), 1048-1055.Oxford University Press (OUP). doi: 10.1093/gerona/62.9.1048.
Rosano, C., Aizenstein, H.J., Wu, M., Newman, A.B., Becker, J.T., Lopez, O.L., & Kuller, L.H. (2007). Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adults. J Neuroimaging, 17(2), 148-155.Wiley. doi: 10.1111/j.1552-6569.2007.00093.x.
Thompson, P.M., Hayashi, K.M., Dutton, R.A., Chiang, M.C., Leow, A.D., Sowell, E.R., De Zubicaray, G., Becker, J.T., Lopez, O.L., Aizenstein, H.J., & Toga, A.W. (2007). Tracking Alzheimer's disease. Ann N Y Acad Sci, 1097(1), 183-214.Wiley. doi: 10.1196/annals.1379.017.
Wagner, A., Aizenstein, H., Venkatraman, V.K., Fudge, J., May, J.C., Mazurkewicz, L., Frank, G.K., Bailer, U.F., Fischer, L., Nguyen, V., Carter, C., Putnam, K., & Kaye, W.H. (2007). Altered reward processing in women recovered from anorexia nervosa. Am J Psychiatry, 164(12), 1842-1849.American Psychiatric Association Publishing. doi: 10.1176/appi.ajp.2007.07040575.
Wu, M., Rosano, C., Lopez-Garcia, P., Carter, C.S., & Aizenstein, H.J. (2007). Optimum template selection for atlas-based segmentation. Neuroimage, 34(4), 1612-1618.Elsevier. doi: 10.1016/j.neuroimage.2006.07.050.
Aizenstein, H.J., Butters, M.A., Clark, K.A., Figurski, J.L., Andrew Stenger, V., Nebes, R.D., Reynolds, C.F., & Carter, C.S. (2006). Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning. Neurobiol Aging, 27(5), 741-751.Elsevier. doi: 10.1016/j.neurobiolaging.2005.03.017.
Frank, G.K., Wagner, A., Achenbach, S., McConaha, C., Skovira, K., Aizenstein, H., Carter, C.S., & Kaye, W.H. (2006). Altered brain activity in women recovered from bulimic-type eating disorders after a glucose challenge: a pilot study. Int J Eat Disord, 39(1), 76-79.Wiley. doi: 10.1002/eat.20210.
Lepore, N., Brun, C.A., Chiang, M.C., Chou, Y.Y., Dutton, R.A., Hayashi, K.M., Lopez, O.L., Aizenstein, H.J., Toga, A.W., Becker, J.T., & Thompson, P.M. (2006). Multivariate statistics of the Jacobian matrices in tensor based morphometry and their application to HIV/AIDS. Med Image Comput Comput Assist Interv, 9(Pt 1), 191-198.Springer Nature. doi: 10.1007/11866565_24.
Lopez-Garcia, P., Aizenstein, H.J., Snitz, B.E., Walter, R.P., & Carter, C.S. (2006). Automated ROI-based brain parcellation analysis of frontal and temporal brain volumes in schizophrenia. Psychiatry Res, 147(2-3), 153-161.Elsevier. doi: 10.1016/j.pscychresns.2006.04.007.
Thompson, P.M., Dutton, R.A., Hayashi, K.M., Lu, A., Lee, S.E., Lee, J.Y., Lopez, O.L., Aizenstein, H.J., Toga, A.W., & Becker, J.T. (2006). 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS. Neuroimage, 31(1), 12-23.Elsevier. doi: 10.1016/j.neuroimage.2005.11.043.
Wagner, A., Aizenstein, H., Frank, G.K., Figurski, J., May, J.C., Putnam, K., Fischer, L., Bailer, U.F., Henry, S.E., McConaha, C., Vogel, V., & Kaye, W.H. (2006). Neural correlates of habituation to taste stimuli in healthy women. Psychiatry Res, 147(1), 57-67.Elsevier. doi: 10.1016/j.pscychresns.2005.11.005.
Wu, M., Carmichael, O., Lopez-Garcia, P., Carter, C.S., & Aizenstein, H.J. (2006). Quantitative comparison of AIR, SPM, and the fully deformable model for atlas-based segmentation of functional and structural MR images. Hum Brain Mapp, 27(9), 747-754.Wiley. doi: 10.1002/hbm.20216.
Wu, M., Rosano, C., Butters, M., Whyte, E., Nable, M., Crooks, R., Meltzer, C.C., Reynolds, C.F., & Aizenstein, H.J. (2006). A fully automated method for quantifying and localizing white matter hyperintensities on MR images. Psychiatry Res, 148(2-3), 133-142.Elsevier. doi: 10.1016/j.pscychresns.2006.09.003.
Aizenstein, H.J., Butters, M.A., Figurski, J.L., Stenger, V.A., Reynolds, C.F., & Carter, C.S. (2005). Prefrontal and striatal activation during sequence learning in geriatric depression. Biol Psychiatry, 58(4), 290-296.Elsevier. doi: 10.1016/j.biopsych.2005.04.023.
Becker, J.T., Aizenstein, H., & Butters, M.A. (2005). Structural and functional neuroimaging findings in normal and pathological aging. In Geriatric Neuropsychology: Practice Essentials. (pp. 141-163). doi: 10.4324/9780203943403-21.
Carmichael, O.T., Aizenstein, H.A., Davis, S.W., Becker, J.T., Thompson, P.M., Meltzer, C.C., & Liu, Y. (2005). Atlas-based hippocampus segmentation in Alzheimer's disease and mild cognitive impairment. Neuroimage, 27(4), 979-990.Elsevier. doi: 10.1016/j.neuroimage.2005.05.005.
Gildengers, A.G., Houck, P.R., Mulsant, B.H., Dew, M.A., Aizenstein, H.J., Jones, B.L., Greenhouse, J., Pollock, B.G., & Reynolds, C.F. (2005). Trajectories of treatment response in late-life depression: psychosocial and clinical correlates. J Clin Psychopharmacol, 25(4 Suppl 1), S8-13.Wolters Kluwer. doi: 10.1097/01.jcp.0000161498.81137.12.
Kerns, J.G., Cohen, J.D., MacDonald, A.W., Johnson, M.K., Stenger, V.A., Aizenstein, H., & Carter, C.S. (2005). Decreased conflict- and error-related activity in the anterior cingulate cortex in subjects with schizophrenia. Am J Psychiatry, 162(10), 1833-1839.American Psychiatric Association Publishing. doi: 10.1176/appi.ajp.162.10.1833.
Rosano, C., Aizenstein, H., Cochran, J., Saxton, J., De Kosky, S., Newman, A.B., Kuller, L.H., Lopez, O.L., & Carter, C.S. (2005). Functional neuroimaging indicators of successful executive control in the oldest old. Neuroimage, 28(4), 881-889.Elsevier. doi: 10.1016/j.neuroimage.2005.05.059.
Rosano, C., Aizenstein, H.J., Cochran, J.L., Saxton, J.A., De Kosky, S.T., Newman, A.B., Kuller, L.H., Lopez, O.L., & Carter, C.S. (2005). Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment. Biol Psychiatry, 57(7), 761-767.Elsevier. doi: 10.1016/j.biopsych.2004.12.031.
Rosano, C., Becker, J., Lopez, O., Lopez-Garcia, P., Carter, C.S., Newman, A., Kuller, L., & Aizenstein, H. (2005). Morphometric analysis of gray matter volume in demented older adults: exploratory analysis of the cardiovascular health study brain MRI database. Neuroepidemiology, 24(4), 221-229.Karger Publishers. doi: 10.1159/000085140.
Thompson, P.M., Dutton, R.A., Hayashi, K.M., Toga, A.W., Lopez, O.L., Aizenstein, H.J., & Becker, J.T. (2005). Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline. Proc Natl Acad Sci U S A, 102(43), 15647-15652.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0502548102.
Aizenstein, H.J., Clark, K.A., Butters, M.A., Cochran, J., Stenger, V.A., Meltzer, C.C., Reynolds, C.F., & Carter, C.S. (2004). The BOLD hemodynamic response in healthy aging. J Cogn Neurosci, 16(5), 786-793.MIT Press. doi: 10.1162/089892904970681.
Aizenstein, H.J., Stenger, V.A., Cochran, J., Clark, K., Johnson, M., Nebes, R.D., & Carter, C.S. (2004). Regional brain activation during concurrent implicit and explicit sequence learning. Cereb Cortex, 14(2), 199-208.Oxford University Press (OUP). doi: 10.1093/cercor/bhg119.
Becker, J.T., Lopez, O.L., Dew, M.A., & Aizenstein, H.J. (2004). Prevalence of cognitive disorders differs as a function of age in HIV virus infection. AIDS, 18 Suppl 1(Supplement 1), S11-S18.Wolters Kluwer. doi: 10.1097/00002030-200418001-00003.
Liu, Y.X., Teverovskiy, L., Carmichael, O., Kikinis, R., Shenton, M., Carter, C.S., Stenger, V.A., Davis, S., Aizenstein, H., Becker, J.T., Lopez, O.L., & Meltzer, C.C. (2004). Discriminative MR image feature analysis for automatic schizophrenia and Alzheimer's disease classification. MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2004, PT 1, PROCEEDINGS, 3216(PART 1), 393-401.Springer Nature. doi: 10.1007/978-3-540-30135-6_48.
Perez-Madriñan, G., Cook, S.E., Saxton, J.A., Miyahara, S., Lopez, O.L., Kaufer, D.I., Aizenstein, H.J., DeKosky, S.T., & Sweet, R.A. (2004). Alzheimer Disease With Psychosis: Excess Cognitive Impairment Is Restricted to the Misidentification Subtype. American Journal of Geriatric Psychiatry, 12(5), 449-456.Elsevier. doi: 10.1097/00019442-200409000-00003.
Aizenstein, H.J., Nebes, R.D., Meltzer, C.C., Fukui, M.B., Williams, R.L., Saxton, J., Houck, P.R., Carter, C.S., Reynolds, C.F., & DeKosky, S.T. (2002). The relation of White Matter Hyperintensities to implicit learning in healthy older adults. Int J Geriatr Psychiatry, 17(7), 664-669.Wiley. doi: 10.1002/gps.685.
Aizenstein, H.J., & Reynolds, C.F. (2001). The treatment of geriatric depression: Progress and challenges. Economics of Neuroscience, 3(7), 58-62.
Nebes, R.D., Butters, M.A., Houck, P.R., Zmuda, M.D., Aizenstein, H., Pollock, B.G., Mulsant, B.H., & Reynolds, C.F. (2001). Dual-task performance in depressed geriatric patients. Psychiatry Res, 102(2), 139-151.Elsevier. doi: 10.1016/s0165-1781(01)00244-x.
Aizenstein, H.J., MacDonald, A.W., Stenger, V.A., Nebes, R.D., Larson, J.K., Ursu, S., & Carter, C.S. (2000). Complementary category learning systems identified using event-related functional MRI. J Cogn Neurosci, 12(6), 977-987.MIT Press. doi: 10.1162/08989290051137512.
Aizenstein, H., Blum, A., Khardon, R., Kushilevitz, E., Pitt, L., & Roth, D. (1998). On learning read-k-satisfy-j DNF. SIAM JOURNAL ON COMPUTING, 27(6), 1515-1530.Society for Industrial & Applied Mathematics (SIAM). doi: 10.1137/S0097539794274398.
Aizenstein, H., Hegedus, T., Hellerstein, L., & Pitt, L. (1998). Complexity theoretic hardness results for query learning. COMPUTATIONAL COMPLEXITY, 7(1), 19-53.Springer Nature. doi: 10.1007/PL00001593.
Aizenstein, H., & Pitt, L. (1995). On the learnability of disjunctive normal form formulas. Machine Learning, 19(3), 183-208. doi: 10.1007/BF00996269.
AIZENSTEIN, H., & PITT, L. (1995). ON THE LEARNABILITY OF DISJUNCTIVE NORMAL-FORM FORMULAS. MACHINE LEARNING, 19(3), 183-208.Springer Nature. doi: 10.1023/A:1022697326858.
Aizenstein, H.J. (1992). Computer systems for medical diagnoses. JAMA, 267(1), 166-170.American Medical Association (AMA). doi: 10.1001/jama.267.1.166.

Sicilia, A., Zhao, X., Minhas, D.S., O'Connor, E.E., Aizenstein, H.J., Klunk, W.E., Tudorascu, D.L., & Hwang, S.J. (2021). MULTI-DOMAIN LEARNING BY META-LEARNING: TAKING OPTIMAL STEPS IN MULTI-DOMAIN LOSS LANDSCAPES BY INNER-LOOP LEARNING. In Proc IEEE Int Symp Biomed Imaging, 2021, (pp. 650-654).Institute of Electrical and Electronics Engineers (IEEE).United States. doi: 10.1109/ISBI48211.2021.9433977.
Vogt, K.M., Ibinson, J.W., Smith, C.T., Citro, A.T., Norton, C.M., Karim, H.T., Popov, V., Mahajan, A., Aizenstein, H.J., Reder, L.M., & Fiez, J.A. (2021). Midazolam and Ketamine Produce Distinct Neural Changes in Memory, Pain, and Fear Networks during Pain. In Anesthesiology, 135(1), (pp. 69-82).Wolters Kluwer.United States. doi: 10.1097/ALN.0000000000003774.
Zhao, X., Sicilia, A., Minhas, D.S., O'Connor, E.E., Aizenstein, H.J., Klunk, W.E., Tudorascu, D.L., & Hwang, S.J. (2021). ROBUST WHITE MATTER HYPERINTENSITY SEGMENTATION ON UNSEEN DOMAIN. In Proc IEEE Int Symp Biomed Imaging, 2021, (pp. 1047-1051).Institute of Electrical and Electronics Engineers (IEEE).United States. doi: 10.1109/ISBI48211.2021.9434034.
Edelman, K., Tudorascu, D., Agudelo, C., Snitz, B., Karim, H., Cohen, A., Mathis, C., Price, J., Weissfeld, L., Klunk, W., & Aizenstein, H. (2017). Amyloid-Beta Deposition is Associated with Increased Medial Temporal Lobe Activation during Memory Encoding in the Cognitively Normal Elderly. Poster session presented at the meeting of Human Amyloid Imaging meeting.England.
P. Santos, F., F. Smagula, S., Karim, H., S. Santini, T., J. Aizenstein, H., S. Ibrahim, T., & D. Maciel, C. (2017). Dynamic Bayesian Network Modeling of Hippocampal Subfields Connectivity with 7T fMRI: A Case Study. In Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies, 4, (pp. 178-184).INSTICC. doi: 10.5220/0006151601780184.
Stetten, G., Wong, C., Shivaprabhu, V., Zhang, A., Horvath, S., Wang, J., Galeotti, J., Gorantla, V., & Aizenstein, H. (2013). Descending Variance Graphs for Segmenting Neurological Structures. In 2013 International Workshop on Pattern Recognition in Neuroimaging, (pp. 174-177).Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/prni.2013.52.
Zheng, H., Zhao, T., Edelman, K., Qian, Y., Ibrahim, T.S., Aizenstein, H., & Boada, F.E. (2012). Improved response to face recognition in UHF fMRI through parallel transmission RF pulse design. In F1000 Research.F1000 Research Ltd..Beijing, China.
Leporé, N., Chou, Y.Y., Lopez, O.L., Aizenstein, H.J., Becker, J.T., Toga, A.W., & Thompson, P.M. (2008). Fast 3D Fluid Registration of Brain Magnetic Resonance Images. In Hu, X.P., & Clough, A.V. (Eds.). In Proc SPIE Int Soc Opt Eng, 6916, (p. 69160z-69160z-8).SPIE, the international society for optics and photonics.United States. doi: 10.1117/12.774338.
Leporé, N., Brun, C., Pennec, X., Chou, Y.Y., Lopez, O.L., Aizenstein, H.J., Becker, J.T., Toga, A.W., & Thompson, P.M. (2007). Mean template for tensor-based morphometry using deformation tensors. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 4792 LNCS(PART 2), (pp. 826-833).
Liu, Y., Teverovskiy, L.A., Lopez, O.L., Aizenstein, H., Meltzer, C.C., & Becker, J.T. (2007). DICOVERY OF "BIOMARKERS" FOR ALZHEIMER'S DISEASE PREDICTION FROM STRUCTURAL MR IMAGES. In 2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, (pp. 1344-1347).Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/isbi.2007.357109.
Tamburo, R.J., Siegle, G.J., Stetten, G.D., Cois, C.A., Rockot, K.J., Galeotti, J.M., Reynolds, C.F., & Aizenstein, H.J. (2007). Localizing Amygdala Structure Differences in Late-Life Depression. In 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, (pp. 340-343).Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/isbi.2007.356858.
Teverovskiy, L.A., Carmichael, O.T., Aizenstein, H.J., Lazar, N., & Liu, Y. (2007). Feature-Based vs. Intensity-Based Brain Image Registration: Comprehensive Comparison Using Mutual Information. In 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, (pp. 576-579).Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/isbi.2007.356917.
Carmichael, O.T., Thompson, P.M., Dutton, R.A., Lu, A., Lee, S.E., Lee, J.Y., Kuller, L.H., Lopez, O.L., Aizenstein, H.J., Meltzer, C.C., Liu, Y., Toga, A.W., & Becker, J.T. (2006). Mapping ventricular changes related to dementia and mild cognitive impairment in a large community-based cohort. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings, 2006, (pp. 315-318).
Chiang, M.C., Dutton, R.A., Hayashi, K.M., Toga, A.W., Lopez, O.L., Aizenstein, H.J., Becker, J.T., & Thompson, P.M. (2006). Fluid registration of medical images using Jensen-Rényi Divergence reveals 3D profile of brain atrophy in HIV/AIDS. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings, 2006, (pp. 193-196).
Lepore, N., Brun, C.A., Chiang, M.C., Chou, Y.Y., Dutton, R.A., Hayashi, K.M., Lopez, O.L., Aizenstein, H.J., Toga, A.W., Becker, J.T., & Thompson, P.M. (2006). Multivariate statistics of the jacobian matrices in tensor based morphometry and their application to HIV/AIDS. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 4190 LNCS - I, (pp. 191-198). doi: 10.1007/11866565_24.
Aizenstein, H., & Pitt, L. (1992). Exact learning of read- k disjoint DNF and not-so-disjoint DNF. In Proceedings of the fifth annual workshop on Computational learning theory, (pp. 71-76).Association for Computing Machinery (ACM). doi: 10.1145/130385.130393.
Aizenstein, H., Hellerstein, L., & Pitt, L. (1992). Read-thrice DNF is hard to learn with membership and equivalence queries. In Proceedings., 33rd Annual Symposium on Foundations of Computer Science, 1992-October, (pp. 523-532).Institute of Electrical and Electronics Engineers (IEEE). doi: 10.1109/sfcs.1992.267799.
Aizenstein, H., & Pitt, L. (1991). Exact learning of read-twice DNF formulas. In Annual Symposium on Foundations of Computer Science (Proceedings), (pp. 170-179).

Research Interests

Clinical sciences Biological psychology Neurosciences Clinical and health psychology Health services and systems Cognitive and computational psychology

Contact Howard Aizenstein

Professor

aizensteinhj@UPMC.EDU

Work: (412) 383-5452

Howard Aizenstein

Publications

Presentations