PhD, University of Pittsburgh
BS, University of Pittsburgh
Kim, J., Yuan, Y., Agaronyan, K., Zhao, A., Wang, V.D., Gau, D., Toosi, N., Gupta, G., Essayas, H., Kaminski, A., McGovern, J., Yu, S., Woo, S., Lee, C.J., Gandhi, S., Saber, T., Saleh, T., Hu, B., Sun, Y., Ishikawa, G., Bain, W., Evankovich, J., Chen, L., Yun, H., Herzog, E.L., Dela Cruz, C.S., Ryu, C., & Sharma, L. (2025). Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection. Mucosal Immunol, 18(3), 537-548.Elsevier. doi: 10.1016/j.mucimm.2025.01.008.
Allen-Gondringer, A., Gau, D., Varghese, C., Boone, D., Stolz, D., Larregina, A., & Roy, P. (2023). Vascular endothelial cell-specific disruption of the profilin1 gene leads to severe multiorgan pathology and inflammation causing mortality. In Yortsos, Y. (Ed.). PNAS Nexus, 2(10), pgad305.Oxford University Press (OUP). doi: 10.1093/pnasnexus/pgad305.
Clark, R.M., Besterfield-Sacre, M., Dickerson, S., & Gau, D. (2023). Impact of COVID-19 on Engineering Students in the Middle Phases of the Pandemic: Academic Motivation, Valued College Experiences, and Stress. INTERNATIONAL JOURNAL OF ENGINEERING EDUCATION, 39(1), 30-47.
Gau, D., Daoud, A., Allen, A., Joy, M., Sagan, A., Lee, S., Lucas, P.C., Duensing, S., Boone, D., Osmanbeyoglu, H.U., & Roy, P. (2023). Vascular endothelial profilin-1 drives a protumorigenic tumor microenvironment and tumor progression in renal cancer. J Biol Chem, 299(8), 105044.Elsevier. doi: 10.1016/j.jbc.2023.105044.
Allen, A., Gau, D., & Roy, P. (2021). The role of profilin-1 in cardiovascular diseases. J Cell Sci, 134(9), jcs249060.The Company of Biologists. doi: 10.1242/jcs.249060.
Gau, D., Vignaud, L., Francoeur, P., Koes, D., Guillonneau, X., & Roy, P. (2021). Inhibition of ocular neovascularization by novel anti-angiogenic compound. Exp Eye Res, 213, 108861.Elsevier. doi: 10.1016/j.exer.2021.108861.
Allen, A., Gau, D., Francoeur, P., Sturm, J., Wang, Y., Martin, R., Maranchie, J., Duensing, A., Kaczorowski, A., Duensing, S., Wu, L., Lotze, M.T., Koes, D., Storkus, W.J., & Roy, P. (2020). Actin-binding protein profilin1 promotes aggressiveness of clear-cell renal cell carcinoma cells. J Biol Chem, 295(46), 15636-15649.Elsevier. doi: 10.1074/jbc.RA120.013963.
Gau, D., Vignaud, L., Allen, A., Guo, Z., Sahel, J., Boone, D., Koes, D., Guillonneau, X., & Roy, P. (2020). Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization. J Biol Chem, 295(28), 9618-9629.Elsevier. doi: 10.1074/jbc.RA120.012613.
Goldschmidt, E., Schneck, M., Gau, D.M., Carey, L., Rasmussen, J., Ferreyro, B., Ajler, P., Snyderman, C., Wang, E., Fernandez-Miranda, J., & Gardner, P.A. (2020). Effect of oxidized cellulose on human respiratory mucosa and submucosa and its implications for endoscopic skull-base approaches. Int Forum Allergy Rhinol, 10(3), 282-288.Wiley. doi: 10.1002/alr.22495.
Gau, D., Veon, W., Shroff, S.G., & Roy, P. (2019). The VASP-profilin1 (Pfn1) interaction is critical for efficient cell migration and is regulated by cell-substrate adhesion in a PKA-dependent manner. J Biol Chem, 294(17), 6972-6985.Elsevier. doi: 10.1074/jbc.RA118.005255.
Chakraborty, S., Jiang, C., Gau, D., Oddo, M., Ding, Z., Vollmer, L., Joy, M., Schiemann, W., Stolz, D.B., Vogt, A., Ghosh, S., & Roy, P. (2018). Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells. Br J Cancer, 119(9), 1106-1117.Springer Nature. doi: 10.1038/s41416-018-0284-6.
Gau, D., & Roy, P. (2018). SRF'ing and SAP'ing - the role of MRTF proteins in cell migration. J Cell Sci, 131(19), jcs218222.The Company of Biologists. doi: 10.1242/jcs.218222.
Gau, D., Lewis, T., McDermott, L., Wipf, P., Koes, D., & Roy, P. (2018). Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1-actin interaction. J Biol Chem, 293(7), 2606-2616.Elsevier. doi: 10.1074/jbc.M117.809137.
Gau, D., Veon, W., Capasso, T.L., Bottcher, R., Shroff, S., Roman, B.L., & Roy, P. (2017). Pharmacological intervention of MKL/SRF signaling by CCG-1423 impedes endothelial cell migration and angiogenesis. Angiogenesis, 20(4), 663-672.Springer Nature. doi: 10.1007/s10456-017-9560-y.
Joy, M., Gau, D., Castellucci, N., Prywes, R., & Roy, P. (2017). The myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms. J Biol Chem, 292(28), 11777-11791.Elsevier. doi: 10.1074/jbc.M117.781104.
Gau, D., Veon, W., Zeng, X., Yates, N., Shroff, S.G., Koes, D.R., & Roy, P. (2016). Threonine 89 Is an Important Residue of Profilin-1 That Is Phosphorylatable by Protein Kinase A. In Paudel, H.K. (Ed.). PLoS One, 11(5), e0156313.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0156313.
Gau, D.M., Lesnock, J.L., Hood, B.L., Bhargava, R., Sun, M., Darcy, K., Luthra, S., Chandran, U., Conrads, T.P., Edwards, R.P., Kelley, J.L., Krivak, T.C., & Roy, P. (2015). BRCA1 deficiency in ovarian cancer is associated with alteration in expression of several key regulators of cell motility - A proteomics study. Cell Cycle, 14(12), 1884-1892.Taylor & Francis. doi: 10.1080/15384101.2015.1036203.
Coumans, J.V.F., Gau, D., Poljak, A., Wasinger, V., Roy, P., & Moens, P. (2014). Green fluorescent protein expression triggers proteome changes in breast cancer cells. Exp Cell Res, 320(1), 33-45.Elsevier. doi: 10.1016/j.yexcr.2013.07.019.
Coumans, J.V.F., Gau, D., Poljak, A., Wasinger, V., Roy, P., & Moens, P.D.J. (2014). Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses. OMICS, 18(12), 778-791.Mary Ann Liebert. doi: 10.1089/omi.2014.0075.
Gau, D., Veon, W., Koes, D., Shroff, S., & Roy, P. (2014). T89 Phosphorylation is a Novel Post-Translational Modification for Critical Structure-Function Regulation of Profilin-1. MOLECULAR BIOLOGY OF THE CELL, 25.
Salvemini, I.L., Gau, D.M., Reid, J., Bagatolli, L.A., Macmillan, A., & Moens, P.D.J. (2014). Low PIP(2) molar fractions induce nanometer size clustering in giant unilamellar vesicles. Chem Phys Lipids, 177, 51-63.Elsevier BV. doi: 10.1016/j.chemphyslip.2013.11.003.
Gau, D., Ding, Z., Baty, C., & Roy, P. (2011). Fluorescence Resonance Energy Transfer (FRET)-based Detection of Profilin-VASP Interaction. Cell Mol Bioeng, 4(1), 1-8.Springer Nature. doi: 10.1007/s12195-010-0133-z.
Ding, Z., Gau, D., Deasy, B., Wells, A., & Roy, P. (2009). Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells. Exp Cell Res, 315(17), 2963-2973.Elsevier. doi: 10.1016/j.yexcr.2009.07.004.
Chawla, P., Gau, D.M., Sun, Q., Boone, D., Galson, D., & Roy, P. (2023). MRTF-SRF interaction promotes bone metastasis of breast cancer cells. In MOLECULAR BIOLOGY OF THE CELL, 34(2), (pp. 992-993).
Gau, D., Allen, A., Daoud, A., Kunkel, J., Paranjape, A.N., Villanueva, F.S., & Roy, P. (2023). Vascular endothelial profilin-1 Inhibition suppresses tumor progression in renal cancer. In MOLECULAR BIOLOGY OF THE CELL, 34(2), (p. 408).
Gau, D., Allen, A., Daoud, A., Kunkel, J., Paranjape, A.N., Villanueva, F.S., & Roy, P. (2023). Vascular endothelial profilin-1 Inhibition suppresses tumor progression in renal cancer. In MOLECULAR BIOLOGY OF THE CELL, 34(2), (pp. 991-992).
Orenberg, A., Gau, D., Ohayon, L., Ricci, M., Bae, Y., Hammond, G., & Roy, P. (2023). Phosphoinositide Metabolism by Actin-Regulatory Protein in Cancer. In MOLECULAR BIOLOGY OF THE CELL, 34(2), (p. 734).
Yu, V., Eder, I., Gau, D., Boone, D., & Roy, P. (2023). Disruption of MRTF-SRF interaction impairs membrane dynamics and motility of breast cancer cells. In MOLECULAR BIOLOGY OF THE CELL, 34(2), (p. 474).
Gau, D.M., Chakraborty, S., Boone, D., Wells, A., & Roy, P. (2019). MRTF|Profilin is an important signaling axis for metastatic outgrowth of triple negative breast cancer cells. In CANCER RESEARCH, 79(13), (p. lb-043-lb-043).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.AM2019-LB-043.
Gau, D., Joy, M., Prywes, R., & Roy, P. (2017). Cellular externalization control of actin-binding protein profilin-1 is a novel mechanism for MKL-dependent regulation of cell migration. In MOLECULAR BIOLOGY OF THE CELL, 28.
Gau, D., Lewis, T., Mcdermott, L., Wipf, P., Koes, D., & Roy, P. (2017). Structure-based virtual screening to identify first-generation inhibitor of profilin1: actin interaction with anti-angiogenic property. In MOLECULAR BIOLOGY OF THE CELL, 28.
Sunseri, J., Koes, D.R., Roy, P., & Gau, D. (2017). Characterization of Profilin Binding Kinetics using Ensemble Molecular Dynamics Simulations. In BIOPHYSICAL JOURNAL, 112(3), (p. 287A).Elsevier. doi: 10.1016/j.bpj.2016.11.1554.
Gau, D., Veon, W., Capasso, T., Joy, M.E., Roman, B., Koes, D., & Roy, P. (2016). Small molecule-mediated inhibitions of transcriptional cofactor MKL and its downstream target profilin impedes endothelial cell migration and angiogenesis. In MOLECULAR BIOLOGY OF THE CELL, 27.
Joy, M.E., Gau, D., Castellucci, N., & Roy, P. (2016). Profilin occupies a critical node in actin/MKL/SRF signaling circuit. In MOLECULAR BIOLOGY OF THE CELL, 27.
Gau, D., Veon, W., Guo, Z., & Roy, P. (2015). Hyperactivation of Protein Kinase A inhibits endothelial cell migration and angiogenesis through phosphorylating and inhibiting actin-binding protein Profilin-1. In MOLECULAR BIOLOGY OF THE CELL, 26.
Jiang, C., Ding, Z., Joy, M., Vollmer, L., Gau, D., Kim, S.H., Singh, S., Vogt, A., & Roy, P. (2015). Profilin-1 is a key determinant for tumorigenic potential of breast cancer cells. In CANCER RESEARCH, 75(15_Supplement), (p. 4941).American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.AM2015-4941.
Gau, D.M., Lesnock, J., Krivak, T., Edwards, R., & Roy, P. (2014). BRCA1 impacts ovarian cancer cell migration through modulating Pfn1 expression. Annual meeting of the American Association of Cancer Research. doi: 10.1158/1538-7445.AM2014-LB-70.
Gau, D., Salvemini, I., Reid, J., Bagatolli, L., & Moens, P. (2013). Low PIP2 Molar Fractions Induce Nanometer Size Clustering in Giant Unilamellar Vesicles Containing POPC. In BIOPHYSICAL JOURNAL, 104(2), (p. 85A).Elsevier. doi: 10.1016/j.bpj.2012.11.512.
Gau, D., Salvemini, I., Reid, J., Bagatolli, L., & Moens, P. (2012). Low PIP2 molar fractions induce nanometer size clustering in giant unilamellar vesicles containing POPC. In MOLECULAR BIOLOGY OF THE CELL, 23, (pp. 51-63).Elsevier. doi: 10.1016/j.chemphyslip.2013.11.003.