Cynthia St Hilaire

Cuevas, R.A., Hortells, L., Chu, C.C., Wong, R., Crane, A., Boufford, C.K., Regan, C., Moorhead, W.J., Bashline, M.J., Parwal, A., Parise, A.M., Behzadi, P., Brown, M.J., Gurkar, A.U., Bruemmer, D., Sembrat, J., Sultan, I., Gleason, T.G., Billaud, M., & St Hilaire, C. (2025). Non-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease. Circ Res, 136(4), 403-421.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.122.321889.

Behzadi, P., & St Hilaire, C. (2024). Aging Two-Step: SOX9's Influence on Vascular Stiffness and Senescence. Circ Res, 134(3), 325-327.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.124.324212.

Behzadi, P., & St Hilaire, C. (2024). Metabolites and metabolism in vascular calcification: links between adenosine signaling and the methionine cycle. Am J Physiol Heart Circ Physiol, 327(6), H1361-H1375.American Physiological Society. doi: 10.1152/ajpheart.00267.2024.

Behzadi, P., Cuevas, R.A., Crane, A., Wendling, A.A., Chu, C.C., Moorhead, W.J., Wong, R., Brown, M., Tamakloe, J., Suresh, S., Salehi, P., Jaffe, I.Z., Kuipers, A.L., Lukashova, L., Verdelis, K., & St Hilaire, C. (2024). Rapamycin Reduces Arterial Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification. bioRxiv, 5.0(08-15), 2024.08.01.606196.Cold Spring Harbor Laboratory. doi: 10.1101/2024.08.01.606196.

Cuevas, R.A., Behzadi, P., & St Hilaire, C. (2024). gNR4Aly Link Bridging Cellular Metabolism, Lactylation, and Vascular Calcification. Circ Res, 134(11), 1448-1450.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.124.324572.

Ferrante, E.A., Cudrici, C.D., Rashidi, M., Fu, Y.P., Huffstutler, R., Carney, K., Chen, M.Y., St Hilaire, C., Smith, K., Bagheri, H., Katz, J.D., Ferreira, C.R., Gahl, W.A., Boehm, M., & Brofferio, A. (2024). Pilot study to evaluate the safety and effectiveness of etidronate treatment for arterial calcification due to deficiency of CD73 (ACDC). Vasc Med, 29(3), 245-255.SAGE Publications. doi: 10.1177/1358863X241235669.

Cuevas, R.A., Wong, R., Joolharzadeh, P., Moorhead, W.J., Chu, C.C., Callahan, J., Crane, A., Boufford, C.K., Parise, A.M., Parwal, A., Behzadi, P., & St Hilaire, C. (2023). Ecto-5'-nucleotidase (Nt5e/CD73)-mediated adenosine signaling attenuates TGFβ-2 induced elastin and cellular contraction. Am J Physiol Cell Physiol, 324(2), C327-C338.American Physiological Society. doi: 10.1152/ajpcell.00054.2022.

Harper, R.L., Fang, F., San, H., Negro, A., St Hilaire, C., Yang, D., Chen, G., Yu, Z., Dmitrieva, N.I., Lanzer, J., Davaine, J.M., Schwartzbeck, R., Walts, A.D., Kovacic, J.C., & Boehm, M. (2023). Mast cell activation and degranulation in acute artery injury: A target for post-operative therapy. FASEB J, 37(7), e23029.Wiley. doi: 10.1096/fj.202201745RR.

Kroll, R.G., Powell, C., Chen, J., Snider, N.T., St Hilaire, C., Reddy, A., Kim, J., Pinsky, D.J., Murthy, V.L., & Sutton, N.R. (2023). Circulating Ectonucleotidases Signal Impaired Myocardial Perfusion at Rest and Stress. J Am Heart Assoc, 12(9), e027920.Wolters Kluwer. doi: 10.1161/JAHA.122.027920.

St Hilaire, C. (2023). Cardiovascular Organoids/3D Models Review Series: an Introduction. Circ Res, 132(4), 481-482.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.123.322561.

Sutton, N.R., Malhotra, R., St Hilaire, C., Aikawa, E., Blumenthal, R.S., Gackenbach, G., Goyal, P., Johnson, A., Nigwekar, S.U., Shanahan, C.M., Towler, D.A., Wolford, B.N., & Chen, Y. (2023). Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification. Arterioscler Thromb Vasc Biol, 43(1), 15-29.Wolters Kluwer. doi: 10.1161/ATVBAHA.122.317332.

Cuevas, R.A., & St Hilaire, C. (2022). Lnc'ing Metabolic Regulation of Epigenetic Modifications to Atherosclerotic Calcification. Circ Res, 130(10), 1583-1585.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.122.321142.

Kant, S., Tran, K.V., Kvandova, M., Caliz, A.D., Yoo, H.J., Learnard, H., Dolan, A.C., Craige, S.M., Hall, J.D., Jiménez, J.M., St Hilaire, C., Schulz, E., Kröller-Schön, S., & Keaney, J.F. (2022). PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1. Arterioscler Thromb Vasc Biol, 42(1), 19-34.Wolters Kluwer. doi: 10.1161/ATVBAHA.121.317066.

St Hilaire, C. (2022). Medial Arterial Calcification: A Significant and Independent Contributor of Peripheral Artery Disease. Arterioscler Thromb Vasc Biol, 42(3), 253-260.Wolters Kluwer. doi: 10.1161/ATVBAHA.121.316252.

Cudrici, C.D., Newman, K.A., Ferrante, E.A., Huffstutler, R., Carney, K., Betancourt, B., Miettinen, M., Siegel, R., Katz, J.D., Nesti, L.J., St Hilaire, C., Lakshmipathy, D., Wen, H., Bagheri, M.H., Boehm, M., & Brofferio, A. (2021). Multifocal calcific periarthritis with distinctive clinical and radiological features in patients with CD73 deficiency. Rheumatology (Oxford), 61(1), 163-173.Oxford University Press (OUP). doi: 10.1093/rheumatology/keab270.

Cuevas, R.A., & St Hilaire, C. (2021). Introduction to the Aortic Valve Disease Review Series. Circ Res, 128(9), 1327-1329.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.121.319286.

Cuevas, R.A., Chu, C.C., Moorhead, W.J., Wong, R., Sultan, I., & St Hilaire, C. (2021). Isolation of Human Primary Valve Cells for In vitro Disease Modeling. J Vis Exp, 2021(170).MyJove. doi: 10.3791/62439.

Li, Y., Kračun, D., Dustin, C.M., El Massry, M., Yuan, S., Goossen, C.J., DeVallance, E.R., Sahoo, S., St Hilaire, C., Gurkar, A.U., Finkel, T., Straub, A.C., Cifuentes-Pagano, E., & Pagano, P.J. (2021). Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence. Proc Natl Acad Sci U S A, 118(42), e2015666118.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.2015666118.

Ouimet, M., Bauer, R.C., & St Hilaire, C. (2021). Building Your Mentoring Network in Your Early Career. Arterioscler Thromb Vasc Biol, 41(10), 2513-2515.Wolters Kluwer. doi: 10.1161/ATVBAHA.121.316802.

Satoh, T., Wang, L., Espinosa-Diez, C., Wang, B., Hahn, S.A., Noda, K., Rochon, E.R., Dent, M.R., Levine, A.R., Baust, J.J., Wyman, S., Wu, Y.L., Triantafyllou, G.A., Tang, Y., Reynolds, M., Shiva, S., Hilaire, C.S., Gomez, D., Goncharov, D.A., Goncharova, E.A., Chan, S.Y., Straub, A.C., Lai, Y.C., McTiernan, C.F., & Gladwin, M.T. (2021). Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction. Circulation, 144(8), 615-637.Wolters Kluwer. doi: 10.1161/CIRCULATIONAHA.121.053889.

Moorhead, W.J., Chu, C.C., Cuevas, R.A., Callahan, J., Wong, R., Regan, C., Boufford, C.K., Sur, S., Liu, M., Gomez, D., MacTaggart, J.N., Kamenskiy, A., Boehm, M., & St Hilaire, C. (2020). Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease. Arterioscler Thromb Vasc Biol, 40(7), 1680-1694.Wolters Kluwer. doi: 10.1161/ATVBAHA.119.313765.

St Hilaire, C. (2020). Retinoids: Dissolving the Calcification Paradox. Arterioscler Thromb Vasc Biol, 40(3), 503-505.Wolters Kluwer. doi: 10.1161/ATVBAHA.119.313854.

Carlsten, M., Namazi, A., Reger, R., Levy, E., Berg, M., St Hilaire, C., & Childs, R.W. (2019). Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5. Oncoimmunology, 8(2), e1534664.Taylor & Francis. doi: 10.1080/2162402X.2018.1534664.

Joolharzadeh, P., & St Hilaire, C. (2019). CD73 (Cluster of Differentiation 73) and the Differences Between Mice and Humans. Arterioscler Thromb Vasc Biol, 39(3), 339-348.Wolters Kluwer. doi: 10.1161/ATVBAHA.118.311579.

Gomez, D., Baylis, R.A., Durgin, B.G., Newman, A.A.C., Alencar, G.F., Mahan, S., St Hilaire, C., Müller, W., Waisman, A., Francis, S.E., Pinteaux, E., Randolph, G.J., Gram, H., & Owens, G.K. (2018). Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice. Nat Med, 24(9), 1418-1429.Springer Nature. doi: 10.1038/s41591-018-0124-5.

Hortells, L., Sur, S., & St Hilaire, C. (2018). Cell Phenotype Transitions in Cardiovascular Calcification. Front Cardiovasc Med, 5, 27.Frontiers. doi: 10.3389/fcvm.2018.00027.

Xue, Y., St Hilaire, C., Hortells, L., Phillippi, J.A., Sant, V., & Sant, S. (2017). Shape-Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Valvular Interstitial Cell Culture. Cell Mol Bioeng, 10(5), 483-500.Springer Nature. doi: 10.1007/s12195-017-0495-6.

Garland, B.T., Boehm, M., Grayson, P.C., Hilaire, C.S., Brofferio, A., & Starnes, B.W. (2016). Abnormal molecular response to Takayasu arteritis causing extensive large-vessel calcification. J Vasc Surg Cases Innov Tech, 2(4), 190-192.Elsevier. doi: 10.1016/j.jvscit.2016.05.004.

Jin, H., St Hilaire, C., Huang, Y., Yang, D., Dmitrieva, N.I., Negro, A., Schwartzbeck, R., Liu, Y., Yu, Z., Walts, A., Davaine, J.M., Lee, D.Y., Donahue, D., Hsu, K.S., Chen, J., Cheng, T., Gahl, W., Chen, G., & Boehm, M. (2016). Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC. Sci Signal, 9(458), ra121.American Association for the Advancement of Science (AAAS). doi: 10.1126/scisignal.aaf9109.

Roman, B.L., & St Hilaire, C. (2016). Catching a Disease: A Molecular Trap as a Therapy for Pulmonary Arterial Hypertension. Am J Respir Crit Care Med, 194(9), 1047-1049.American Thoracic Society. doi: 10.1164/rccm.201605-0920ED.

St Hilaire, C., Liberman, M., Miller, J.D., & Early Career Committee. (2016). Bidirectional Translation in Cardiovascular Calcification. Arterioscler Thromb Vasc Biol, 36(3), e19-e24.Wolters Kluwer. doi: 10.1161/ATVBAHA.115.307056.

Boehm, M., & Hilaire, C.S. (2015). Vascular Genetics. In PanVascular Medicine. (pp. 53-88).Springer Nature. doi: 10.1007/978-3-642-37078-6_4.

Cooley, B.C., Nevado, J., Mellad, J., Yang, D., St Hilaire, C., Negro, A., Fang, F., Chen, G., San, H., Walts, A.D., Schwartzbeck, R.L., Taylor, B., Lanzer, J.D., Wragg, A., Elagha, A., Beltran, L.E., Berry, C., Feil, R., Virmani, R., Ladich, E., Kovacic, J.C., & Boehm, M. (2014). TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med, 6(227), 227ra34.American Association for the Advancement of Science (AAAS). doi: 10.1126/scitranslmed.3006927.

Cooley, B.C., Nevado, J., Mellad, J., Yang, D., St Hilaire, C., Negro, A., Fang, F., Chen, G., San, H., Walts, A.D., Schwartzbeck, R.L., Taylor, B., Lanzer, J.D., Wragg, A., Elagha, A., Beltran, L.E., Berry, C., Feil, R., Virmani, R., Ladich, E., Kovacic, J.C., & Boehm, M. (2014). Untitled. SCIENCE TRANSLATIONAL MEDICINE, 6(227).

Lanzer, P., Boehm, M., Sorribas, V., Thiriet, M., Janzen, J., Zeller, T., St Hilaire, C., & Shanahan, C. (2014). Medial vascular calcification revisited: review and perspectives. Eur Heart J, 35(23), 1515-1525.Oxford University Press (OUP). doi: 10.1093/eurheartj/ehu163.

Liu, Y., Jesus, A.A., Marrero, B., Yang, D., Ramsey, S.E., Sanchez, G.A.M., Tenbrock, K., Wittkowski, H., Jones, O.Y., Kuehn, H.S., Lee, C.C.R., DiMattia, M.A., Cowen, E.W., Gonzalez, B., Palmer, I., DiGiovanna, J.J., Biancotto, A., Kim, H., Tsai, W.L., Trier, A.M., Huang, Y., Stone, D.L., Hill, S., Kim, H.J., St Hilaire, C., Gurprasad, S., Plass, N., Chapelle, D., Horkayne-Szakaly, I., Foell, D., Barysenka, A., Candotti, F., Holland, S.M., Hughes, J.D., Mehmet, H., Issekutz, A.C., Raffeld, M., McElwee, J., Fontana, J.R., Minniti, C.P., Moir, S., Kastner, D.L., Gadina, M., Steven, A.C., Wingfield, P.T., Brooks, S.R., Rosenzweig, S.D., Fleisher, T.A., Deng, Z., Boehm, M., Paller, A.S., & Goldbach-Mansky, R. (2014). Activated STING in a vascular and pulmonary syndrome. N Engl J Med, 371(6), 507-518.Massachusetts Medical Society. doi: 10.1056/NEJMoa1312625.

Negro, A., St. Hilaire, C., & Boehm, M. (2012). Cell-Based Regenerative Therapies: Role of Major Histocompatibility Complex-1 Antigen. In Stem Cells and Cancer Stem Cells,Volume 3. (pp. 173-178).Springer Nature. doi: 10.1007/978-94-007-2415-0_16.

Boehm, M., St Hilaire, C., & Gahl, W.A. (2011). NT5E Mutations and Arterial Calcifications REPLY. NEW ENGLAND JOURNAL OF MEDICINE, 364(16), 1579-1580.

Eltzschig, H.K., & Robson, S.C. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(16), 1577-1578. doi: 10.1056/NEJMc1102515.

Hofbauer, L.C., Hamann, C., & Schoppet, M. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(16), 1578. doi: 10.1056/NEJMc1102515.

Markello, T.C., Pak, L.K., St Hilaire, C., Dorward, H., Ziegler, S.G., Chen, M.Y., Chaganti, K., Nussbaum, R.L., Boehm, M., & Gahl, W.A. (2011). Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum. Mol Genet Metab, 103(1), 44-50.Elsevier. doi: 10.1016/j.ymgme.2011.01.018.

Markello, T.C., St Hilaire, C., Ziegler, S.G., Nussbaum, R.L., Boehm, M., & Gahl, W.A. (2011). Reply to Professor Lefthériotis et al. Mol Genet Metab, 103(3), 305.Elsevier. doi: 10.1016/j.ymgme.2011.04.008.

Riksen, N.P., & Rongen, G.A. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(16), 1579.Massachusetts Medical Society. doi: 10.1056/NEJMc1102515.

Schrader, J. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(16), 1578-1579. doi: 10.1056/NEJMc1102515.

Schrader, J. (2011). NT5E Mutations and Arterial Calcifications. NEW ENGLAND JOURNAL OF MEDICINE, 364(16), 1578-1579.

St Hilaire, C., Ziegler, S.G., Markello, T.C., Brusco, A., Groden, C., Gill, F., Carlson-Donohoe, H., Lederman, R.J., Chen, M.Y., Yang, D., Siegenthaler, M.P., Arduino, C., Mancini, C., Freudenthal, B., Stanescu, H.C., Zdebik, A.A., Chaganti, R.K., Nussbaum, R.L., Kleta, R., Gahl, W.A., & Boehm, M. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(5), 432-442.Massachusetts Medical Society. doi: 10.1056/NEJMoa0912923.

Zylka, M.J., & Sowa, N.A. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(16), 1579. doi: 10.1056/NEJMc1102515.

Kovacic, J.C., Gupta, R., Lee, A.C., Ma, M., Fang, F., Tolbert, C.N., Walts, A.D., Beltran, L.E., San, H., Chen, G., St Hilaire, C., & Boehm, M. (2010). Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. J Clin Invest, 120(1), 303-314.American Society for Clinical Investigation. doi: 10.1172/JCI40364.

Nguyen, H.G., Makitalo, M., Yang, D., Chinnappan, D., St Hilaire, C., & Ravid, K. (2009). Deregulated Aurora-B induced tetraploidy promotes tumorigenesis. FASEB J, 23(8), 2741-2748.Wiley. doi: 10.1096/fj.09-130963.

St Hilaire, C., Carroll, S.H., Chen, H., & Ravid, K. (2009). Mechanisms of induction of adenosine receptor genes and its functional significance. J Cell Physiol, 218(1), 35-44.Wiley. doi: 10.1002/jcp.21579.

Hurtado, P.A., Vora, S., Sume, S.S., Yang, D., St Hilaire, C., Guo, Y., Palamakumbura, A.H., Schreiber, B.M., Ravid, K., & Trackman, P.C. (2008). Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation. Biochem Biophys Res Commun, 366(1), 156-161.Elsevier. doi: 10.1016/j.bbrc.2007.11.116.

St Hilaire, C., Koupenova, M., Carroll, S.H., Smith, B.D., & Ravid, K. (2008). TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4. Biochem Biophys Res Commun, 375(3), 292-296.Elsevier. doi: 10.1016/j.bbrc.2008.07.059.

St Hilaire, C., Yang, D., Schreiber, B.M., & Ravid, K. (2008). B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells. J Cell Biochem, 103(6), 1962-1974.Wiley. doi: 10.1002/jcb.21586.

Yang, D., McCrann, D.J., Nguyen, H., St Hilaire, C., DePinho, R.A., Jones, M.R., & Ravid, K. (2007). Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell, 6(2), 257-260.Wiley. doi: 10.1111/j.1474-9726.2007.00274.x.

Hazony, Y., Lu, J., St Hilaire, C., & Ravid, K. (2006). Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature. Nucleic Acids Res, 34(16), 4416-4428.Oxford University Press (OUP). doi: 10.1093/nar/gkl578.

Yang, D., Zhang, Y., Nguyen, H.G., Koupenova, M., Chauhan, A.K., Makitalo, M., Jones, M.R., St Hilaire, C., Seldin, D.C., Toselli, P., Lamperti, E., Schreiber, B.M., Gavras, H., Wagner, D.D., & Ravid, K. (2006). The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest, 116(7), 1913-1923.American Society for Clinical Investigation. doi: 10.1172/JCI27933.

Nagata, Y., Jones, M.R., Nguyen, H.G., McCrann, D.J., St Hilaire, C., Schreiber, B.M., Hashimoto, A., Inagaki, M., Earnshaw, W.C., Todokoro, K., & Ravid, K. (2005). Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle. Exp Cell Res, 305(2), 277-291.Elsevier. doi: 10.1016/j.yexcr.2004.12.028.

Vallée, M.A., Keating, P., Smith, R.S., & St-Hilaire, C. (2004). Estimating depth and model type using the continuous wavelet transform of magnetic data. GEOPHYSICS, 69(1), 191-199.Society of Exploration Geophysicists. doi: 10.1190/1.1649387.

Al-Baradie, R., Yamada, K., St Hilaire, C., Chan, W.M., Andrews, C., McIntosh, N., Nakano, M., Martonyi, E.J., Raymond, W.R., Okumura, S., Okihiro, M.M., & Engle, E.C. (2002). Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family. Am J Hum Genet, 71(5), 1195-1199.Elsevier. doi: 10.1086/343821.

Anderson, E., Deisler, P.F., McCallum, D., Hilaire, C.S., Spitzer, H.L., Strauss, H., Wilson, J.D., & Zimmerman, R. (1993). Key issues in carcinogen risk assessment guidelines, Society for Risk Analysis. Risk Anal, 13(4), 379-382.Wiley. doi: 10.1111/j.1539-6924.1993.tb00737.x.

Hilaire, C.S. (2017). Autophagy in Vascular Calcification. In ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37.

St Hilaire, C., Kyaw, M.T., & Boehm, M. (2013). Modulation of IGF2-mediated PI3K/MEK signaling is implicated in the vascular calcification of a rare monogenetic disease. In ANGIOGENESIS, 16(1), (p. 264).

Engle, E.C., Al-Baradie, R., St Hilaire, C., Moy, R., Xu, P.X., & Maas, R. (2002). Linkage mapping and candidate gene analysis of Duane syndrome with radial ray anomalities (Okihiro syndrome). In JOURNAL OF THE NEUROLOGICAL SCIENCES, 199, (pp. S98-S99).