Cynthia St Hilaire

Behzadi, P., & St Hilaire, C. (2024). Aging Two-Step: SOX9's Influence on Vascular Stiffness and Senescence. Circ Res, 134(3), 325-327.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.124.324212.

Behzadi, P., & St Hilaire, C. (2024). Metabolites and metabolism in vascular calcification: links between adenosine signaling and the methionine cycle. Am J Physiol Heart Circ Physiol, 327(6), H1361-H1375.American Physiological Society. doi: 10.1152/ajpheart.00267.2024.

Behzadi, P., Cuevas, R.A., Crane, A., Wendling, A.A., Chu, C.C., Moorhead, W.J., Wong, R., Brown, M., Tamakloe, J., Suresh, S., Salehi, P., Jaffe, I.Z., Kuipers, A.L., Lukashova, L., Verdelis, K., & St Hilaire, C. (2024). Rapamycin Reduces Arterial Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification. bioRxiv, 5.0(08-15), 2024.08.01.606196.Cold Spring Harbor Laboratory. doi: 10.1101/2024.08.01.606196.

Cuevas, R.A., Behzadi, P., & St Hilaire, C. (2024). gNR4Aly Link Bridging Cellular Metabolism, Lactylation, and Vascular Calcification. Circ Res, 134(11), 1448-1450.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.124.324572.

Ferrante, E.A., Cudrici, C.D., Rashidi, M., Fu, Y.P., Huffstutler, R., Carney, K., Chen, M.Y., St Hilaire, C., Smith, K., Bagheri, H., Katz, J.D., Ferreira, C.R., Gahl, W.A., Boehm, M., & Brofferio, A. (2024). Pilot study to evaluate the safety and effectiveness of etidronate treatment for arterial calcification due to deficiency of CD73 (ACDC). Vasc Med, 29(3), 245-255.SAGE Publications. doi: 10.1177/1358863X241235669.

Cuevas, R.A., Wong, R., Joolharzadeh, P., Moorhead, W.J., Chu, C.C., Callahan, J., Crane, A., Boufford, C.K., Parise, A.M., Parwal, A., Behzadi, P., & St Hilaire, C. (2023). Ecto-5'-nucleotidase (Nt5e/CD73)-mediated adenosine signaling attenuates TGFβ-2 induced elastin and cellular contraction. Am J Physiol Cell Physiol, 324(2), C327-C338.American Physiological Society. doi: 10.1152/ajpcell.00054.2022.

Harper, R.L., Fang, F., San, H., Negro, A., St Hilaire, C., Yang, D., Chen, G., Yu, Z., Dmitrieva, N.I., Lanzer, J., Davaine, J.M., Schwartzbeck, R., Walts, A.D., Kovacic, J.C., & Boehm, M. (2023). Mast cell activation and degranulation in acute artery injury: A target for post-operative therapy. FASEB J, 37(7), e23029.Wiley. doi: 10.1096/fj.202201745RR.

Kroll, R.G., Powell, C., Chen, J., Snider, N.T., St Hilaire, C., Reddy, A., Kim, J., Pinsky, D.J., Murthy, V.L., & Sutton, N.R. (2023). Circulating Ectonucleotidases Signal Impaired Myocardial Perfusion at Rest and Stress. J Am Heart Assoc, 12(9), e027920.Wolters Kluwer. doi: 10.1161/JAHA.122.027920.

St Hilaire, C. (2023). Cardiovascular Organoids/3D Models Review Series: an Introduction. Circ Res, 132(4), 481-482.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.123.322561.

Sutton, N.R., Malhotra, R., St Hilaire, C., Aikawa, E., Blumenthal, R.S., Gackenbach, G., Goyal, P., Johnson, A., Nigwekar, S.U., Shanahan, C.M., Towler, D.A., Wolford, B.N., & Chen, Y. (2023). Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification. Arterioscler Thromb Vasc Biol, 43(1), 15-29.Wolters Kluwer. doi: 10.1161/ATVBAHA.122.317332.

Cuevas, R.A., & St Hilaire, C. (2022). Lnc'ing Metabolic Regulation of Epigenetic Modifications to Atherosclerotic Calcification. Circ Res, 130(10), 1583-1585.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.122.321142.

Kant, S., Tran, K.V., Kvandova, M., Caliz, A.D., Yoo, H.J., Learnard, H., Dolan, A.C., Craige, S.M., Hall, J.D., Jiménez, J.M., St Hilaire, C., Schulz, E., Kröller-Schön, S., & Keaney, J.F. (2022). PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1. Arterioscler Thromb Vasc Biol, 42(1), 19-34.Wolters Kluwer. doi: 10.1161/ATVBAHA.121.317066.

St Hilaire, C. (2022). Medial Arterial Calcification: A Significant and Independent Contributor of Peripheral Artery Disease. Arterioscler Thromb Vasc Biol, 42(3), 253-260.Wolters Kluwer. doi: 10.1161/ATVBAHA.121.316252.

Cudrici, C.D., Newman, K.A., Ferrante, E.A., Huffstutler, R., Carney, K., Betancourt, B., Miettinen, M., Siegel, R., Katz, J.D., Nesti, L.J., St Hilaire, C., Lakshmipathy, D., Wen, H., Bagheri, M.H., Boehm, M., & Brofferio, A. (2021). Multifocal calcific periarthritis with distinctive clinical and radiological features in patients with CD73 deficiency. Rheumatology (Oxford), 61(1), 163-173.Oxford University Press (OUP). doi: 10.1093/rheumatology/keab270.

Cuevas, R.A., & St Hilaire, C. (2021). Introduction to the Aortic Valve Disease Review Series. Circ Res, 128(9), 1327-1329.Wolters Kluwer. doi: 10.1161/CIRCRESAHA.121.319286.

Cuevas, R.A., Chu, C.C., Moorhead, W.J., Wong, R., Sultan, I., & St Hilaire, C. (2021). Isolation of Human Primary Valve Cells for In vitro Disease Modeling. J Vis Exp, 2021(170).MyJove. doi: 10.3791/62439.

Li, Y., Kračun, D., Dustin, C.M., El Massry, M., Yuan, S., Goossen, C.J., DeVallance, E.R., Sahoo, S., St Hilaire, C., Gurkar, A.U., Finkel, T., Straub, A.C., Cifuentes-Pagano, E., & Pagano, P.J. (2021). Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence. Proc Natl Acad Sci U S A, 118(42), e2015666118.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.2015666118.

Ouimet, M., Bauer, R.C., & St Hilaire, C. (2021). Building Your Mentoring Network in Your Early Career. Arterioscler Thromb Vasc Biol, 41(10), 2513-2515.Wolters Kluwer. doi: 10.1161/ATVBAHA.121.316802.

Satoh, T., Wang, L., Espinosa-Diez, C., Wang, B., Hahn, S.A., Noda, K., Rochon, E.R., Dent, M.R., Levine, A.R., Baust, J.J., Wyman, S., Wu, Y.L., Triantafyllou, G.A., Tang, Y., Reynolds, M., Shiva, S., Hilaire, C.S., Gomez, D., Goncharov, D.A., Goncharova, E.A., Chan, S.Y., Straub, A.C., Lai, Y.C., McTiernan, C.F., & Gladwin, M.T. (2021). Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction. Circulation, 144(8), 615-637.Wolters Kluwer. doi: 10.1161/CIRCULATIONAHA.121.053889.

Moorhead, W.J., Chu, C.C., Cuevas, R.A., Callahan, J., Wong, R., Regan, C., Boufford, C.K., Sur, S., Liu, M., Gomez, D., MacTaggart, J.N., Kamenskiy, A., Boehm, M., & St Hilaire, C. (2020). Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease. Arterioscler Thromb Vasc Biol, 40(7), 1680-1694.Wolters Kluwer. doi: 10.1161/ATVBAHA.119.313765.

St Hilaire, C. (2020). Retinoids: Dissolving the Calcification Paradox. Arterioscler Thromb Vasc Biol, 40(3), 503-505.Wolters Kluwer. doi: 10.1161/ATVBAHA.119.313854.

Carlsten, M., Namazi, A., Reger, R., Levy, E., Berg, M., St Hilaire, C., & Childs, R.W. (2019). Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5. Oncoimmunology, 8(2), e1534664.Taylor & Francis. doi: 10.1080/2162402X.2018.1534664.

Joolharzadeh, P., & St Hilaire, C. (2019). CD73 (Cluster of Differentiation 73) and the Differences Between Mice and Humans. Arterioscler Thromb Vasc Biol, 39(3), 339-348.Wolters Kluwer. doi: 10.1161/ATVBAHA.118.311579.

Gomez, D., Baylis, R.A., Durgin, B.G., Newman, A.A.C., Alencar, G.F., Mahan, S., St Hilaire, C., Müller, W., Waisman, A., Francis, S.E., Pinteaux, E., Randolph, G.J., Gram, H., & Owens, G.K. (2018). Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice. Nat Med, 24(9), 1418-1429.Springer Nature. doi: 10.1038/s41591-018-0124-5.

Hortells, L., Sur, S., & St Hilaire, C. (2018). Cell Phenotype Transitions in Cardiovascular Calcification. Front Cardiovasc Med, 5, 27.Frontiers. doi: 10.3389/fcvm.2018.00027.

Xue, Y., St Hilaire, C., Hortells, L., Phillippi, J.A., Sant, V., & Sant, S. (2017). Shape-Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Valvular Interstitial Cell Culture. Cell Mol Bioeng, 10(5), 483-500.Springer Nature. doi: 10.1007/s12195-017-0495-6.

Garland, B.T., Boehm, M., Grayson, P.C., Hilaire, C.S., Brofferio, A., & Starnes, B.W. (2016). Abnormal molecular response to Takayasu arteritis causing extensive large-vessel calcification. J Vasc Surg Cases Innov Tech, 2(4), 190-192.Elsevier. doi: 10.1016/j.jvscit.2016.05.004.

Jin, H., St Hilaire, C., Huang, Y., Yang, D., Dmitrieva, N.I., Negro, A., Schwartzbeck, R., Liu, Y., Yu, Z., Walts, A., Davaine, J.M., Lee, D.Y., Donahue, D., Hsu, K.S., Chen, J., Cheng, T., Gahl, W., Chen, G., & Boehm, M. (2016). Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC. Sci Signal, 9(458), ra121.American Association for the Advancement of Science (AAAS). doi: 10.1126/scisignal.aaf9109.

Roman, B.L., & St Hilaire, C. (2016). Catching a Disease: A Molecular Trap as a Therapy for Pulmonary Arterial Hypertension. Am J Respir Crit Care Med, 194(9), 1047-1049.American Thoracic Society. doi: 10.1164/rccm.201605-0920ED.

St Hilaire, C., Liberman, M., Miller, J.D., & Early Career Committee. (2016). Bidirectional Translation in Cardiovascular Calcification. Arterioscler Thromb Vasc Biol, 36(3), e19-e24.Wolters Kluwer. doi: 10.1161/ATVBAHA.115.307056.

Boehm, M., & Hilaire, C.S. (2015). Vascular Genetics. In PanVascular Medicine. (pp. 53-88).Springer Nature. doi: 10.1007/978-3-642-37078-6_4.

Cooley, B.C., Nevado, J., Mellad, J., Yang, D., St Hilaire, C., Negro, A., Fang, F., Chen, G., San, H., Walts, A.D., Schwartzbeck, R.L., Taylor, B., Lanzer, J.D., Wragg, A., Elagha, A., Beltran, L.E., Berry, C., Feil, R., Virmani, R., Ladich, E., Kovacic, J.C., & Boehm, M. (2014). TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med, 6(227), 227ra34.American Association for the Advancement of Science (AAAS). doi: 10.1126/scitranslmed.3006927.

Cooley, B.C., Nevado, J., Mellad, J., Yang, D., St Hilaire, C., Negro, A., Fang, F., Chen, G., San, H., Walts, A.D., Schwartzbeck, R.L., Taylor, B., Lanzer, J.D., Wragg, A., Elagha, A., Beltran, L.E., Berry, C., Feil, R., Virmani, R., Ladich, E., Kovacic, J.C., & Boehm, M. (2014). Untitled. SCIENCE TRANSLATIONAL MEDICINE, 6(227).

Lanzer, P., Boehm, M., Sorribas, V., Thiriet, M., Janzen, J., Zeller, T., St Hilaire, C., & Shanahan, C. (2014). Medial vascular calcification revisited: review and perspectives. Eur Heart J, 35(23), 1515-1525.Oxford University Press (OUP). doi: 10.1093/eurheartj/ehu163.

Liu, Y., Jesus, A.A., Marrero, B., Yang, D., Ramsey, S.E., Sanchez, G.A.M., Tenbrock, K., Wittkowski, H., Jones, O.Y., Kuehn, H.S., Lee, C.C.R., DiMattia, M.A., Cowen, E.W., Gonzalez, B., Palmer, I., DiGiovanna, J.J., Biancotto, A., Kim, H., Tsai, W.L., Trier, A.M., Huang, Y., Stone, D.L., Hill, S., Kim, H.J., St Hilaire, C., Gurprasad, S., Plass, N., Chapelle, D., Horkayne-Szakaly, I., Foell, D., Barysenka, A., Candotti, F., Holland, S.M., Hughes, J.D., Mehmet, H., Issekutz, A.C., Raffeld, M., McElwee, J., Fontana, J.R., Minniti, C.P., Moir, S., Kastner, D.L., Gadina, M., Steven, A.C., Wingfield, P.T., Brooks, S.R., Rosenzweig, S.D., Fleisher, T.A., Deng, Z., Boehm, M., Paller, A.S., & Goldbach-Mansky, R. (2014). Activated STING in a vascular and pulmonary syndrome. N Engl J Med, 371(6), 507-518.Massachusetts Medical Society. doi: 10.1056/NEJMoa1312625.

Negro, A., St. Hilaire, C., & Boehm, M. (2012). Cell-Based Regenerative Therapies: Role of Major Histocompatibility Complex-1 Antigen. In Stem Cells and Cancer Stem Cells,Volume 3. (pp. 173-178).Springer Nature. doi: 10.1007/978-94-007-2415-0_16.

Boehm, M., St Hilaire, C., & Gahl, W.A. (2011). NT5E Mutations and Arterial Calcifications REPLY. NEW ENGLAND JOURNAL OF MEDICINE, 364(16), 1579-1580.

Eltzschig, H.K., & Robson, S.C. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(16), 1577-1578. doi: 10.1056/NEJMc1102515.

Hofbauer, L.C., Hamann, C., & Schoppet, M. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(16), 1578. doi: 10.1056/NEJMc1102515.

Markello, T.C., Pak, L.K., St Hilaire, C., Dorward, H., Ziegler, S.G., Chen, M.Y., Chaganti, K., Nussbaum, R.L., Boehm, M., & Gahl, W.A. (2011). Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum. Mol Genet Metab, 103(1), 44-50.Elsevier. doi: 10.1016/j.ymgme.2011.01.018.

Markello, T.C., St Hilaire, C., Ziegler, S.G., Nussbaum, R.L., Boehm, M., & Gahl, W.A. (2011). Reply to Professor Lefthériotis et al. Mol Genet Metab, 103(3), 305.Elsevier. doi: 10.1016/j.ymgme.2011.04.008.

Riksen, N.P., & Rongen, G.A. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(16), 1579.Massachusetts Medical Society. doi: 10.1056/NEJMc1102515.

Schrader, J. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(16), 1578-1579. doi: 10.1056/NEJMc1102515.

Schrader, J. (2011). NT5E Mutations and Arterial Calcifications. NEW ENGLAND JOURNAL OF MEDICINE, 364(16), 1578-1579.

St Hilaire, C., Ziegler, S.G., Markello, T.C., Brusco, A., Groden, C., Gill, F., Carlson-Donohoe, H., Lederman, R.J., Chen, M.Y., Yang, D., Siegenthaler, M.P., Arduino, C., Mancini, C., Freudenthal, B., Stanescu, H.C., Zdebik, A.A., Chaganti, R.K., Nussbaum, R.L., Kleta, R., Gahl, W.A., & Boehm, M. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(5), 432-442.Massachusetts Medical Society. doi: 10.1056/NEJMoa0912923.

Zylka, M.J., & Sowa, N.A. (2011). NT5E mutations and arterial calcifications. N Engl J Med, 364(16), 1579. doi: 10.1056/NEJMc1102515.

Kovacic, J.C., Gupta, R., Lee, A.C., Ma, M., Fang, F., Tolbert, C.N., Walts, A.D., Beltran, L.E., San, H., Chen, G., St Hilaire, C., & Boehm, M. (2010). Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. J Clin Invest, 120(1), 303-314.American Society for Clinical Investigation. doi: 10.1172/JCI40364.

Nguyen, H.G., Makitalo, M., Yang, D., Chinnappan, D., St Hilaire, C., & Ravid, K. (2009). Deregulated Aurora-B induced tetraploidy promotes tumorigenesis. FASEB J, 23(8), 2741-2748.Wiley. doi: 10.1096/fj.09-130963.

St Hilaire, C., Carroll, S.H., Chen, H., & Ravid, K. (2009). Mechanisms of induction of adenosine receptor genes and its functional significance. J Cell Physiol, 218(1), 35-44.Wiley. doi: 10.1002/jcp.21579.

Hurtado, P.A., Vora, S., Sume, S.S., Yang, D., St Hilaire, C., Guo, Y., Palamakumbura, A.H., Schreiber, B.M., Ravid, K., & Trackman, P.C. (2008). Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation. Biochem Biophys Res Commun, 366(1), 156-161.Elsevier. doi: 10.1016/j.bbrc.2007.11.116.

St Hilaire, C., Koupenova, M., Carroll, S.H., Smith, B.D., & Ravid, K. (2008). TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4. Biochem Biophys Res Commun, 375(3), 292-296.Elsevier. doi: 10.1016/j.bbrc.2008.07.059.

St Hilaire, C., Yang, D., Schreiber, B.M., & Ravid, K. (2008). B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells. J Cell Biochem, 103(6), 1962-1974.Wiley. doi: 10.1002/jcb.21586.

Yang, D., McCrann, D.J., Nguyen, H., St Hilaire, C., DePinho, R.A., Jones, M.R., & Ravid, K. (2007). Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell, 6(2), 257-260.Wiley. doi: 10.1111/j.1474-9726.2007.00274.x.

Hazony, Y., Lu, J., St Hilaire, C., & Ravid, K. (2006). Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature. Nucleic Acids Res, 34(16), 4416-4428.Oxford University Press (OUP). doi: 10.1093/nar/gkl578.

Yang, D., Zhang, Y., Nguyen, H.G., Koupenova, M., Chauhan, A.K., Makitalo, M., Jones, M.R., St Hilaire, C., Seldin, D.C., Toselli, P., Lamperti, E., Schreiber, B.M., Gavras, H., Wagner, D.D., & Ravid, K. (2006). The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest, 116(7), 1913-1923.American Society for Clinical Investigation. doi: 10.1172/JCI27933.

Nagata, Y., Jones, M.R., Nguyen, H.G., McCrann, D.J., St Hilaire, C., Schreiber, B.M., Hashimoto, A., Inagaki, M., Earnshaw, W.C., Todokoro, K., & Ravid, K. (2005). Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle. Exp Cell Res, 305(2), 277-291.Elsevier. doi: 10.1016/j.yexcr.2004.12.028.

Vallée, M.A., Keating, P., Smith, R.S., & St-Hilaire, C. (2004). Estimating depth and model type using the continuous wavelet transform of magnetic data. GEOPHYSICS, 69(1), 191-199.Society of Exploration Geophysicists. doi: 10.1190/1.1649387.

Al-Baradie, R., Yamada, K., St Hilaire, C., Chan, W.M., Andrews, C., McIntosh, N., Nakano, M., Martonyi, E.J., Raymond, W.R., Okumura, S., Okihiro, M.M., & Engle, E.C. (2002). Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family. Am J Hum Genet, 71(5), 1195-1199.Elsevier. doi: 10.1086/343821.

Anderson, E., Deisler, P.F., McCallum, D., Hilaire, C.S., Spitzer, H.L., Strauss, H., Wilson, J.D., & Zimmerman, R. (1993). Key issues in carcinogen risk assessment guidelines, Society for Risk Analysis. Risk Anal, 13(4), 379-382.Wiley. doi: 10.1111/j.1539-6924.1993.tb00737.x.

Hilaire, C.S. (2017). Autophagy in Vascular Calcification. In ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37.

St Hilaire, C., Kyaw, M.T., & Boehm, M. (2013). Modulation of IGF2-mediated PI3K/MEK signaling is implicated in the vascular calcification of a rare monogenetic disease. In ANGIOGENESIS, 16(1), (p. 264).

Engle, E.C., Al-Baradie, R., St Hilaire, C., Moy, R., Xu, P.X., & Maas, R. (2002). Linkage mapping and candidate gene analysis of Duane syndrome with radial ray anomalities (Okihiro syndrome). In JOURNAL OF THE NEUROLOGICAL SCIENCES, 199, (pp. S98-S99).