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Chih-Chieh Chang, A., Balic, M., Bartholow, T., Bhargava, R., Brown, D.D., Brown, L., Brufsky, A., Cao, Y., Carleton, N., Clark, A.M., Cody, M., Ding, K., Deible, C., Elangovan, A., Foldi, J., Geisler, D., Hodgdon, C., Howard, N., Li, Z., Liu, J.B., Lopez-Nunez, O., Mary, D.J.S.J., McGinn, O., Miller, L., Mori, K., Pecar, G., Priedigkeit, N., Puhalla, S., Rosenzweig, M.Q., Roy, P., Savariau, L., Walker, S., Waltermire, H., Wedn, A.M., Wells, A., Yates, M.E., Xavier, J., Lee, A.V., & Oesterreich, S. (2025). Hope for Others: Research Results from the University of Pittsburgh Rapid Autopsy Program for Breast Cancer. bioRxiv, 2024.11.06.621982.Cold Spring Harbor Laboratory. doi: 10.1101/2024.11.06.621982.
Jiang, X., Zhou, Y., Xu, C., Brufsky, A., & Wells, A. (2025). Deep Learning: A Heuristic Three-Stage Mechanism for Grid Searches to Optimize the Future Risk Prediction of Breast Cancer Metastasis Using EHR-Based Clinical Data. Cancers (Basel), 17(7), 1092.MDPI. doi: 10.3390/cancers17071092.
Dai, B., Clark, A.M., & Wells, A. (2024). Mesenchymal Stem Cell-Secreted Exosomes and Soluble Signals Regulate Breast Cancer Metastatic Dormancy: Current Progress and Future Outlook. Int J Mol Sci, 25(13), 7133.MDPI. doi: 10.3390/ijms25137133.
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Shao, H., Teramae, D., & Wells, A. (2023). Axl contributes to efficient migration and invasion of melanoma cells. In Chen, S. (Ed.). PLoS One, 18(3), e0283749.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0283749.
Gomez Marti, J.L., Brufsky, A., Wells, A., & Jiang, X. (2022). Machine Learning to Discern Interactive Clusters of Risk Factors for Late Recurrence of Metastatic Breast Cancer. Cancers (Basel), 14(1), 253.MDPI. doi: 10.3390/cancers14010253.
Korentzelos, D., Wells, A., & Clark, A.M. (2022). Interferon-γ increases sensitivity to chemotherapy and provides immunotherapy targets in models of metastatic castration-resistant prostate cancer. Sci Rep, 12(1), 6657.Springer Nature. doi: 10.1038/s41598-022-10724-9.
Phan, T., Boes, S., McCullough, M., Gribschaw, J., & Wells, A. (2022). Development of the one-step qualitative RT-PCR assay to detect SARS-CoV-2 Omicron (B.1.1.529) variant in respiratory specimens. In medRxiv. doi: 10.1101/2022.01.04.22268772.
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Shao, H., Teramae, D., & Wells, A. (2022). Axl contributes to efficient migration and invasion of melanoma cells. In bioRxiv. doi: 10.1101/2022.05.02.490307.
Sylakowski, K., Hwang, M.P., Justin, A., Whaley, D., Wang, Y., & Wells, A. (2022). The matricellular protein decorin delivered intradermally with coacervate improves wound resolution in the CXCR3-deficient mouse model of hypertrophic scarring. Wound Repair Regen, 30(4), 436-447.Wiley. doi: 10.1111/wrr.13017.
Sylakowski, K., Hwang, P., Justin, A., Shao, H., Whaley, D., Wang, Y., & Wells, A. (2022). Matricellular protein Tenascin-C enhances mesenchymal stem cell angiogenic and wound healing efficacy under ischemic conditions. J Tissue Eng Regen Med, 16(12), 1249-1260.Hindawi. doi: 10.1002/term.3367.
Wells, A., Wang, Y., Shao, H., Sohnen, P., & Swamynathan, S.K. (2022). A CXCR3-activating peptide increases Tear Break Up Time and corrects corneal haze in a rabbit model of environmental dry eye. In bioRxiv. doi: 10.1101/2022.12.07.519513.
Zhu, L., Marsh, J.W., Griffith, M.P., Collins, K., Srinivasa, V., Waggle, K., Van Tyne, D., Snyder, G.M., Phan, T., Wells, A., Marroquin, O.C., & Harrison, L.H. (2022). Predictive model for severe COVID-19 using SARS-CoV-2 whole-genome sequencing and electronic health record data, March 2020-May 2021. In Novelli, G. (Ed.). PLoS One, 17(7), e0271381.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0271381.
Agha, M., Blake, M., Chilleo, C., Wells, A., & Haidar, G. (2021). Suboptimal response to COVID-19 mRNA vaccines in hematologic malignancies patients. medRxiv, 2(04-13), 2021.04.06.21254949.Cold Spring Harbor Laboratory. doi: 10.1101/2021.04.06.21254949.
Clark, A.M., Allbritton, N.L., & Wells, A. (2021). Integrative microphysiological tissue systems of cancer metastasis to the liver. Semin Cancer Biol, 71, 157-169.Elsevier. doi: 10.1016/j.semcancer.2020.06.010.
Clark, A.M., Heusey, H.L., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2021). IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment. Front Oncol, 11, 676135.Frontiers. doi: 10.3389/fonc.2021.676135.
Gomez Marti, J.L., Wells, A., & Brufsky, A.M. (2021). Dysregulation of the mevalonate pathway during SARS-CoV-2 infection: An in silico study. J Med Virol, 93(4), 2396-2405.Wiley. doi: 10.1002/jmv.26743.
Haidar, G., Ayres, A., King, W.C., McDonald, M., Wells, A., Mitchell, S.L., Bilderback, A.L., Minnier, T., & Mellors, J.W. (2021). Preprocedural SARS-CoV-2 Testing to Sustain Medically Needed Health Care Delivery During the COVID-19 Pandemic: A Prospective Observational Study. Open Forum Infect Dis, 8(2), ofab022.Oxford University Press (OUP). doi: 10.1093/ofid/ofab022.
Huang, D.T., McCreary, E.K., Bariola, J.R., Wadas, R.J., Kip, K.E., Marroquin, O.C., Koscumb, S., Collins, K., Shovel, J.A., Schmidhofer, M., Wisniewski, M.K., Sullivan, C., Yealy, D.M., Axe, M., Nace, D.A., Haidar, G., Khadem, T., Linstrum, K., Snyder, G.M., Seymour, C.W., Montgomery, S.K., McVerry, B.J., Berry, L., Berry, S., Meyers, R., Weissman, A., Peck-Palmer, O.M., Wells, A., Bart, R., Albin, D.L., Minnier, T., & Angus, D.C. (2021). The UPMC OPTIMISE-C19 (OPtimizing Treatment and Impact of Monoclonal antIbodieS through Evaluation for COVID-19) trial: a structured summary of a study protocol for an open-label, pragmatic, comparative effectiveness platform trial with response-adaptive randomization. Trials, 22(1), 363.Springer Nature. doi: 10.1186/s13063-021-05316-3.
Ma, B., Shao, H., Jiang, X., Wang, Z., Wu, C.C., Whaley, D., & Wells, A. (2021). Akt isoforms differentially provide for chemoresistance in prostate cancer. Cancer Biol Med, 19(5), 635-650.China Anti-cancer Association. doi: 10.20892/j.issn.2095-3941.2020.0747.
Ma, B., Wells, A., Wei, L., & Zheng, J. (2021). Prostate cancer liver metastasis: Dormancy and resistance to therapy. Semin Cancer Biol, 71, 2-9.Elsevier. doi: 10.1016/j.semcancer.2020.07.004.
Marti, J.L.G., Beckwitt, C.H., Clark, A.M., & Wells, A. (2021). Atorvastatin facilitates chemotherapy effects in metastatic triple-negative breast cancer. Br J Cancer, 125(9), 1285-1298.Springer Nature. doi: 10.1038/s41416-021-01529-0.
Marti, J.L.G., Brufsky, A., Wells, A., & Jiang, X. (2021). Machine-Learning to Discern Interactive Clusters of Risk Factors for Late Recurrence of Metastatic Breast Cancer. In Preprints.org. doi: 10.20944/preprints202112.0018.v1.
Marti, J.L.G., Mays, A., McCullough, M., Wells, A., & Phan, T. (2021). Evaluation of viral loads in patients with SARS-CoV-2 Delta variant infection: Higher loads do not translate into different testing scenarios. In medRxiv. doi: 10.1101/2021.10.14.21265031.
Nace, D.A., Kip, K.E., Palmer, O.M.P., Shurin, M.R., Mulvey, K., Crandall, M., Kane, A.L., Lukanski, A., Kip, P.L., & Wells, A.L. (2021). Antibody Responses in Elderly Residential Care Persons following COVID-19 mRNA Vaccination. In medRxiv. doi: 10.1101/2021.04.07.21254925.
Phan, T., Mays, A., McCullough, M., & Wells, A. (2021). Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 test for bronchoalveolar lavage. In medRxiv. doi: 10.1101/2021.12.21.21268190.
Popescu, I., Snyder, M.E., Iasella, C.J., Hannan, S.J., Koshy, R., Burke, R., Das, A., Brown, M.J., Lyons, E.J., Lieber, S.C., Chen, X., Sembrat, J.C., An, X., Linstrum, K., Kitsios, G., Konstantinidis, I., Saul, M., Kass, D.J., Alder, J.K., Chen, B.B., Lendermon, E.A., Kilaru, S., Johnson, B., Morrell, M.R., Pilewski, J.M., Kiss, J.E., Wells, A.H., Morris, A., McVerry, B.J., McMahon, D.K., Triulzi, D.J., Chen, K., Sanchez, P.G., & McDyer, J.F. (2021). CD4+ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent. 2021.06.02.446831.Cold Spring Harbor Laboratory. doi: 10.1101/2021.06.02.446831.
Shao, H., & Wells, A. (2021). Binding of alpha-ACTN4 to EGF receptor enables its rapid phosphorylation. Heliyon, 7(1), e06011.Elsevier. doi: 10.1016/j.heliyon.2021.e06011.
Swogger, J., Conner, I.P., Happ-Smith, C., Kemmerer, M.C., Julian, D.R., Davis, R., Wells, A., Schuman, J.S., & Yates, C.C. (2021). Novel combination therapy reduces subconjunctival fibrosis after glaucoma filtration surgery in the rabbit model. Clin Exp Ophthalmol, 49(1), 60-69.Wiley. doi: 10.1111/ceo.13884.
Sylakowski, K., & Wells, A. (2021). ECM-regulation of autophagy: The yin and the yang of autophagy during wound healing. Matrix Biol, 100-101, 197-206.Elsevier. doi: 10.1016/j.matbio.2020.12.006.
Wells, A., Beckwitt, C., & Marti, J.L.G. (2021). Preventing metastatic emergence of breast cancer. Aging (Albany NY), 13(19), 22627-22628.Impact Journals. doi: 10.18632/aging.203631.
Xu, L., Doyle, J., Barbeau, D.J., Le Sage, V., Wells, A., Duprex, W.P., Shurin, M.R., Wheeler, S.E., & McElroy, A.K. (2021). A Cross-Sectional Study of SARS-CoV-2 Seroprevalence between Fall 2020 and February 2021 in Allegheny County, Western Pennsylvania, USA. Pathogens, 10(6), 710.MDPI. doi: 10.3390/pathogens10060710.
Zilla, M., Wheeler, B.J., Keetch, C., Mitchell, G., McBreen, J., Wells, A., Shurin, M.R., Peck-Palmer, O., & Wheeler, S.E. (2021). Variable Performance in 6 Commercial SARS-CoV-2 Antibody Assays May Affect Convalescent Plasma and Seroprevalence Screening. Am J Clin Pathol, 155(3), 343-353.Oxford University Press (OUP). doi: 10.1093/ajcp/aqaa228.
Jiang, X., Wells, A., Brufsky, A., Shetty, D., Shajihan, K., & Neapolitan, R.E. (2020). Leveraging Bayesian networks and information theory to learn risk factors for breast cancer metastasis. BMC Bioinformatics, 21(1), 298.Springer Nature. doi: 10.1186/s12859-020-03638-8.
Klimstra, W.B., Tilston-Lunel, N.L., Nambulli, S., Boslett, J., McMillen, C.M., Gilliland, T., Dunn, M.D., Sun, C., Wheeler, S.E., Wells, A., Hartman, A.L., McElroy, A.K., Reed, D.S., Rennick, L.J., & Duprex, W.P. (2020). SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients. J Gen Virol, 101(11), 1156-1169.Microbiology Society. doi: 10.1099/jgv.0.001481.
Korentzelos, D., Clark, A.M., & Wells, A. (2020). A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer. Int J Mol Sci, 21(19), 7304.MDPI. doi: 10.3390/ijms21197304.
Ma, B., Wells, A., & Clark, A.M. (2020). The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment. Semin Cancer Biol, 60, 138-147.Elsevier. doi: 10.1016/j.semcancer.2019.07.021.
Shurin, M.R., Morris, A., Wells, A., & Wheeler, S.E. (2020). Assessing Immune Response to SARS-CoV-2 Infection. Immunotargets Ther, 9(0), 111-114.Taylor & Francis. doi: 10.2147/ITT.S264138.
Swamynathan, S.K., & Wells, A. (2020). Conjunctival goblet cells: Ocular surface functions, disorders that affect them, and the potential for their regeneration. Ocul Surf, 18(1), 19-26.Elsevier. doi: 10.1016/j.jtos.2019.11.005.
Swogger, J., Conner, I.P., Rosano, M., Kemmerer, M., Happ-Smith, C., Wells, A., Schuman, J.S., & Yates, C.C. (2020). Injected Versus Sponge-Applied Mitomycin C (MMC) During Modified Trabeculectomy in New Zealand White Rabbit Model. Transl Vis Sci Technol, 9(11), 23.Association for Research in Vision and Ophthalmology (ARVO). doi: 10.1167/tvst.9.11.23.
Sylakowski, K., Bradshaw, A., & Wells, A. (2020). Mesenchymal Stem Cell/Multipotent Stromal Cell Augmentation of Wound Healing: Lessons from the Physiology of Matrix and Hypoxia Support. Am J Pathol, 190(7), 1370-1381.Elsevier. doi: 10.1016/j.ajpath.2020.03.017.
Jiang, X., Wells, A., Brufsky, A., & Neapolitan, R. (2019). A clinical decision support system learned from data to personalize treatment recommendations towards preventing breast cancer metastasis. In Jeong, J. (Ed.). PLoS One, 14(3), e0213292.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0213292.
Jiang, Y., Wells, A., Sylakowski, K., Clark, A.M., & Ma, B. (2019). Adult Stem Cell Functioning in the Tumor Micro-Environment. Int J Mol Sci, 20(10), 2566.MDPI. doi: 10.3390/ijms20102566.
Ma, B., Khazali, A., Shao, H., Jiang, Y., & Wells, A. (2019). Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer. Cell Commun Signal, 17(1), 164.Springer Nature. doi: 10.1186/s12964-019-0489-1.
Shao, H., Wingert, B., Weins, A., Pollak, M.R., Camacho, C., & Wells, A. (2019). Focal segmental glomerulosclerosis ACTN4 mutants binding to actin: regulation by phosphomimetic mutations. Sci Rep, 9(1), 15517.Springer Nature. doi: 10.1038/s41598-019-51825-2.
Beckwitt, C.H., Brufsky, A., Oltvai, Z.N., & Wells, A. (2018). Statin drugs to reduce breast cancer recurrence and mortality. Breast Cancer Res, 20(1), 144.Springer Nature. doi: 10.1186/s13058-018-1066-z.
Beckwitt, C.H., Clark, A.M., Ma, B., Whaley, D., Oltvai, Z.N., & Wells, A. (2018). Statins attenuate outgrowth of breast cancer metastases. Br J Cancer, 119(9), 1094-1105.Springer Nature. doi: 10.1038/s41416-018-0267-7.
Beckwitt, C.H., Clark, A.M., Wheeler, S., Taylor, D.L., Stolz, D.B., Griffith, L., & Wells, A. (2018). Liver 'organ on a chip'. Exp Cell Res, 363(1), 15-25.Elsevier. doi: 10.1016/j.yexcr.2017.12.023.
Beckwitt, C.H., Shiraha, K., & Wells, A. (2018). Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling. In Ghavami, S. (Ed.). PLoS One, 13(5), e0197422.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0197422.
Bradshaw, A., Sylakowski, K., & Wells, A. (2018). The Pro-reparative Engine: Stem Cells Aid Healing by Dampening Inflammation. Curr Pathobiol Rep, 6(2), 109-115.Springer Nature. doi: 10.1007/s40139-018-0167-9.
Clark, A.M., Kumar, M.P., Wheeler, S.E., Young, C.L., Venkataramanan, R., Stolz, D.B., Griffith, L.G., Lauffenburger, D.A., & Wells, A. (2018). A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. Mol Cell Proteomics, 17(4), 619-630.Elsevier. doi: 10.1074/mcp.RA117.000370.
Ishikawa, T., Hosaka, Y.Z., Beckwitt, C., Wells, A., Oltvai, Z.N., & Warita, K. (2018). Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics. Oncotarget, 9(50), 29304-29315.Impact Journals. doi: 10.18632/oncotarget.25448.
Khazali, A.S., Clark, A.M., & Wells, A. (2018). Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy. Br J Cancer, 118(4), 566-576.Springer Nature. doi: 10.1038/bjc.2017.414.
Raghu, V.K., Beckwitt, C.H., Warita, K., Wells, A., Benos, P.V., & Oltvai, Z.N. (2018). Biomarker identification for statin sensitivity of cancer cell lines. Biochem Biophys Res Commun, 495(1), 659-665.Elsevier. doi: 10.1016/j.bbrc.2017.11.065.
Stram, M.N., Suciu, C.N., Seheult, J.N., McCullough, M.A., Kader, M., Wells, A., William Pasculle, A., Rinaldo, C.R., & Ismail, N. (2018). Herpes Simplex Virus-1 qPCR in the Diagnosis of Lower Respiratory Tract Infections in Organ Transplant Recipients and Critically Ill Patients. Am J Clin Pathol, 150(6), 522-532.Oxford University Press (OUP). doi: 10.1093/ajcp/aqy088.
Wells, A., & Wiley, H.S. (2018). A systems perspective of heterocellular signaling. Essays Biochem, 62(4), 607-617.Portland Press. doi: 10.1042/EBC20180015.
Wells, A., Clark, A., Bradshaw, A., Ma, B., & Edington, H. (2018). The great escape: How metastases of melanoma, and other carcinomas, avoid elimination. Exp Biol Med (Maywood), 243(17-18), 1245-1255.Frontiers. doi: 10.1177/1535370218820287.
Zeng, Z., Jiang, X., Li, X., Wells, A., Luo, Y., & Neapolitan, R. (2018). Conjugated equine estrogen and medroxyprogesterone acetate are associated with decreased risk of breast cancer relative to bioidentical hormone therapy and controls. In Härkönen, P.L. (Ed.). PLoS One, 13(5), e0197064.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0197064.
Dioufa, N., Clark, A.M., Ma, B., Beckwitt, C.H., & Wells, A. (2017). Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. Mol Cancer, 16(1), 172.Springer Nature. doi: 10.1186/s12943-017-0740-6.
González, Á., García de Durango, C., Alonso, V., Bravo, B., Rodríguez de Gortázar, A., Wells, A., Forteza, J., & Vidal-Vanaclocha, F. (2017). Distinct Osteomimetic Response of Androgen-Dependent and Independent Human Prostate Cancer Cells to Mechanical Action of Fluid Flow: Prometastatic Implications. Prostate, 77(3), 321-333.Wiley. doi: 10.1002/pros.23270.
Kader, M., Alaoui-El-Azher, M., Vorhauer, J., Kode, B.B., Wells, J.Z., Stolz, D., Michalopoulos, G., Wells, A., Scott, M., & Ismail, N. (2017). MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. In Coers, J. (Ed.). PLoS Pathog, 13(10), e1006644.Public Library of Science (PLoS). doi: 10.1371/journal.ppat.1006644.
Khazali, A.S., Clark, A.M., & Wells, A. (2017). A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms. Stem Cell Rev Rep, 13(3), 364-380.Springer Nature. doi: 10.1007/s12015-017-9735-3.
Raghu, V.K., Beckwitt, C.H., Warita, K., Wells, A., Benos, P.V., & Oltvai, Z.N. (2017). Biomarker identification for statin sensitivity of cancer cell lines. In bioRxiv. doi: 10.1101/215756.
Shao, H., Lauffenburger, D., & Wells, A. (2017). Tyro3 carboxyl terminal region confers stability and contains the autophosphorylation sites. Biochem Biophys Res Commun, 490(3), 1074-1079.Elsevier. doi: 10.1016/j.bbrc.2017.06.168.
Wells, A., & Ma, B. (2017). Friend turned foe: E-cadherin perversely protects micrometastases. Transl Androl Urol, 6(2), 338-340.AME Publishing Company. doi: 10.21037/tau.2017.03.25.
Yates, C.C., Nuschke, A., Rodrigues, M., Whaley, D., Dechant, J.J., Taylor, D.P., & Wells, A. (2017). Improved Transplanted Stem Cell Survival in a Polymer Gel Supplemented With Tenascin C Accelerates Healing and Reduces Scarring of Murine Skin Wounds. Cell Transplant, 26(1), 103-113.SAGE Publications. doi: 10.3727/096368916X692249.
Yates, C.C., Rodrigues, M., Nuschke, A., Johnson, Z.I., Whaley, D., Stolz, D., Newsome, J., & Wells, A. (2017). Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring. Stem Cell Res Ther, 8(1), 193.Springer Nature. doi: 10.1186/s13287-017-0644-9.
Bodnar, R.J., Satish, L., Yates, C.C., & Wells, A. (2016). Pericytes: A newly recognized player in wound healing. Wound Repair Regen, 24(2), 204-214.Wiley. doi: 10.1111/wrr.12415.
Clark, A.M., Ma, B., Taylor, D.L., Griffith, L., & Wells, A. (2016). Liver metastases: Microenvironments and ex-vivo models. Exp Biol Med (Maywood), 241(15), 1639-1652.Frontiers. doi: 10.1177/1535370216658144.
Clark, A.M., Wheeler, S.E., Young, C.L., Stockdale, L., Shepard Neiman, J., Zhao, W., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2016). A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. Lab Chip, 17(1), 156-168.Royal Society of Chemistry (RSC). doi: 10.1039/c6lc01171c.
Gordonov, S., Hwang, M.K., Wells, A., Gertler, F.B., Lauffenburger, D.A., & Bathe, M. (2016). Time series modeling of live-cell shape dynamics for image-based phenotypic profiling. Integr Biol (Camb), 8(1), 73-90.Oxford University Press (OUP). doi: 10.1039/c5ib00283d.
Huen, A.C., Marathi, A., Nam, P.K., & Wells, A. (2016). CXCL11 Expression by Keratinocytes Occurs Transiently Between Reaching Confluence and Cellular Compaction. Adv Wound Care (New Rochelle), 5(12), 517-526.Mary Ann Liebert. doi: 10.1089/wound.2015.0680.
Ma, B., Wheeler, S.E., Clark, A.M., Whaley, D.L., Yang, M., & Wells, A. (2016). Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling. Hepatology, 64(5), 1725-1742.Wolters Kluwer. doi: 10.1002/hep.28755.
Nuschke, A., Rodrigues, M., Rivera, J., Yates, C., Whaley, D., Stolz, D., Griffith, L., & Wells, A. (2016). Epidermal Growth Factor Tethered to β-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. Stem Cells Transl Med, 5(11), 1580-1586.Oxford University Press (OUP). doi: 10.5966/sctm.2015-0326.
Nuschke, A., Rodrigues, M., Wells, A.W., Sylakowski, K., & Wells, A. (2016). Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation. Stem Cell Res Ther, 7(1), 179.Springer Nature. doi: 10.1186/s13287-016-0436-7.
Wells, A., Nuschke, A., & Yates, C.C. (2016). Skin tissue repair: Matrix microenvironmental influences. Matrix Biol, 49, 25-36.Elsevier. doi: 10.1016/j.matbio.2015.08.001.
Yang, M., Ma, B., Shao, H., Clark, A.M., & Wells, A. (2016). Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. BMC Cancer, 16(1), 419.Springer Nature. doi: 10.1186/s12885-016-2411-1.
Bodnar, R.J., & Wells, A. (2015). Differential regulation of pericyte function by the CXC receptor 3. Wound Repair Regen, 23(6), 785-796.Wiley. doi: 10.1111/wrr.12346.
Furukawa, M., Wheeler, S., Clark, A.M., & Wells, A. (2015). Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells. In Samant, R. (Ed.). PLoS One, 10(1), e0118060.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0118060.
Ma, B., Khazali, A., & Wells, A. (2015). CXCR3 in carcinoma progression. Histol Histopathol, 30(7), 781-792. doi: 10.14670/HH-11-594.
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Travers, T., Shao, H., Joughin, B.A., Lauffenburger, D.A., Wells, A., & Camacho, C.J. (2015). Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function. Sci Signal, 8(378), ra51.American Association for the Advancement of Science (AAAS). doi: 10.1126/scisignal.aaa1977.
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Ding, Z., Joy, M., Bhargava, R., Gunsaulus, M., Lakshman, N., Miron-Mendoza, M., Petroll, M., Condeelis, J., Wells, A., & Roy, P. (2014). Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis. Oncogene, 33(16), 2065-2074.Springer Nature. doi: 10.1038/onc.2013.166.
Grahovac, J., & Wells, A. (2014). Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion. Lab Invest, 94(1), 31-40.Elsevier. doi: 10.1038/labinvest.2013.132.
Griffith, L.G., Wells, A., & Stolz, D.B. (2014). Engineering liver. Hepatology, 60(4), 1426-1434.Wolters Kluwer. doi: 10.1002/hep.27150.
Jamison, J., Wang, J.H.C., & Wells, A. (2014). PKCδ regulates force signaling during VEGF/CXCL4 induced dissociation of endothelial tubes. In Hotchin, N.A. (Ed.). PLoS One, 9(4), e93968.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0093968.
Ma, B., & Wells, A. (2014). The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells. J Biol Chem, 289(16), 11153-11161.Elsevier. doi: 10.1074/jbc.M113.540237.
Nuschke, A., Rodrigues, M., Stolz, D.B., Chu, C.T., Griffith, L., & Wells, A. (2014). Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation. Stem Cell Res Ther, 5(6), 140.Springer Nature. doi: 10.1186/scrt530.
Shao, H., Li, S., Watkins, S.C., & Wells, A. (2014). α-Actinin-4 is required for amoeboid-type invasiveness of melanoma cells. J Biol Chem, 289(47), 32717-32728.Elsevier. doi: 10.1074/jbc.M114.579185.
Taylor, D.P., Clark, A., Wheeler, S., & Wells, A. (2014). Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. Breast Cancer Res Treat, 144(3), 551-560.Springer Nature. doi: 10.1007/s10549-014-2875-0.
Warita, K., Warita, T., Beckwitt, C.H., Schurdak, M.E., Vazquez, A., Wells, A., & Oltvai, Z.N. (2014). Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. Sci Rep, 4(1), 7593.Springer Nature. doi: 10.1038/srep07593.
Wheeler, S.E., Clark, A.M., Taylor, D.P., Young, C.L., Pillai, V.C., Stolz, D.B., Venkataramanan, R., Lauffenburger, D., Griffith, L., & Wells, A. (2014). Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system. Br J Cancer, 111(12), 2342-2350.Springer Nature. doi: 10.1038/bjc.2014.533.
Bodnar, R.J., Rodgers, M.E., Chen, W.C.W., & Wells, A. (2013). Pericyte regulation of vascular remodeling through the CXC receptor 3. Arterioscler Thromb Vasc Biol, 33(12), 2818-2829.Wolters Kluwer. doi: 10.1161/ATVBAHA.113.302012.
Grahovac, J., Becker, D., & Wells, A. (2013). Melanoma cell invasiveness is promoted at least in part by the epidermal growth factor-like repeats of tenascin-C. J Invest Dermatol, 133(1), 210-220.Elsevier. doi: 10.1038/jid.2012.263.
Hang, T.C., Tedford, N.C., Reddy, R.J., Rimchala, T., Wells, A., White, F.M., Kamm, R.D., & Lauffenburger, D.A. (2013). Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context. Mol Cell Proteomics, 12(12), 3704-3718.Elsevier. doi: 10.1074/mcp.M113.030528.
Jamison, J., Lauffenburger, D., Wang, J.C.H., & Wells, A. (2013). PKCδ localization at the membrane increases matrix traction force dependent on PLCγ1/EGFR signaling. In Parsons, M. (Ed.). PLoS One, 8(10), e77434.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0077434.
Rodrigues, M., Blair, H., Stockdale, L., Griffith, L., & Wells, A. (2013). Surface tethered epidermal growth factor protects proliferating and differentiating multipotential stromal cells from FasL-induced apoptosis. Stem Cells, 31(1), 104-116.Oxford University Press (OUP). doi: 10.1002/stem.1215.
Rodrigues, M., Yates, C.C., Nuschke, A., Griffith, L., & Wells, A. (2013). The matrikine tenascin-C protects multipotential stromal cells/mesenchymal stem cells from death cytokines such as FasL. Tissue Eng Part A, 19(17-18), 1972-1983.Mary Ann Liebert. doi: 10.1089/ten.TEA.2012.0568.
Shao, H., Travers, T., Camacho, C.J., & Wells, A. (2013). The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading. Int J Biochem Cell Biol, 45(6), 1051-1063.Elsevier. doi: 10.1016/j.biocel.2013.02.015.
Taylor, D.P., Wells, J.Z., Savol, A., Chennubhotla, C., & Wells, A. (2013). Modeling boundary conditions for balanced proliferation in metastatic latency. Clin Cancer Res, 19(5), 1063-1070.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-12-3180.
Travers, T., Shao, H., Wells, A., & Camacho, C.J. (2013). Modeling the assembly of the multiple domains of α-actinin-4 and its role in actin cross-linking. Biophys J, 104(3), 705-715.Elsevier. doi: 10.1016/j.bpj.2012.12.003.
Wells, A., Grahovac, J., Wheeler, S., Ma, B., & Lauffenburger, D. (2013). Targeting tumor cell motility as a strategy against invasion and metastasis. Trends Pharmacol Sci, 34(5), 283-289.Elsevier. doi: 10.1016/j.tips.2013.03.001.
Wells, A., Griffith, L., Wells, J.Z., & Taylor, D.P. (2013). The dormancy dilemma: quiescence versus balanced proliferation. Cancer Res, 73(13), 3811-3816.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-13-0356.
Wheeler, S.E., Borenstein, J.T., Clark, A.M., Ebrahimkhani, M.R., Fox, I.J., Griffith, L., Inman, W., Lauffenburger, D., Nguyen, T., Pillai, V.C., Prantil-Baun, R., Stolz, D.B., Taylor, D., Ulrich, T., Venkataramanan, R., Wells, A., & Young, C. (2013). All-human microphysical model of metastasis therapy. Stem Cell Res Ther, 4 Suppl 1(Suppl 1), S11.Springer Nature. doi: 10.1186/scrt372.
Chao, Y., Wu, Q., Acquafondata, M., Dhir, R., & Wells, A. (2012). Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases. Cancer Microenviron, 5(1), 19-28.Springer Nature. doi: 10.1007/s12307-011-0085-4.
Chao, Y., Wu, Q., Shepard, C., & Wells, A. (2012). Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance. Clin Exp Metastasis, 29(1), 39-50.Springer Nature. doi: 10.1007/s10585-011-9427-3.
Gunasinghe, N.P.A.D., Wells, A., Thompson, E.W., & Hugo, H.J. (2012). Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer. Cancer Metastasis Rev, 31(3-4), 469-478.Springer Nature. doi: 10.1007/s10555-012-9377-5.
Jones, J., Wang, H., Zhou, J., Hardy, S., Turner, T., Austin, D., He, Q., Wells, A., Grizzle, W.E., & Yates, C. (2012). Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells. Am J Pathol, 181(5), 1836-1846.Elsevier. doi: 10.1016/j.ajpath.2012.08.008.
Meyer, A.S., Hughes-Alford, S.K., Kay, J.E., Castillo, A., Wells, A., Gertler, F.B., & Lauffenburger, D.A. (2012). 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. J Cell Biol, 197(6), 721-729.Rockefeller University Press. doi: 10.1083/jcb.201201003.
Park, S., Pantanowitz, L., Parwani, A.V., Wells, A., & Oltvai, Z.N. (2012). Workflow organization in pathology. Clin Lab Med, 32(4), 601-622.Elsevier. doi: 10.1016/j.cll.2012.07.008.
Rodrigues, M., Turner, O., Stolz, D., Griffith, L.G., & Wells, A. (2012). Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand. Cell Transplant, 21(10), 2171-2187.SAGE Publications. doi: 10.3727/096368912X639035.
Wells, A. (2012). Laboratory medicine: a view to the future of diagnostics and training. Rinsho Byori, 60(4), 312-320.
Wells, A., & Oltvai, Z.N. (2012). Ongoing technological revolution. Preface. Clin Lab Med, 32(4), ix-x.Elsevier. doi: 10.1016/j.cll.2012.07.007.
Wu, Q., Dhir, R., & Wells, A. (2012). Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion. Mol Cancer, 11(1), 3.Springer Nature. doi: 10.1186/1476-4598-11-3.
Yates, C.C., Hebda, P., & Wells, A. (2012). Skin wound healing and scarring: fetal wounds and regenerative restitution. Birth Defects Res C Embryo Today, 96(4), 325-333.Wiley. doi: 10.1002/bdrc.21024.
Yates, C.C., Whaley, D., & Wells, A. (2012). Transplanted fibroblasts prevents dysfunctional repair in a murine CXCR3-deficient scarring model. Cell Transplant, 21(5), 919-931.SAGE Publications. doi: 10.3727/096368911X623817.
Yates-Binder, C.C., Rodgers, M., Jaynes, J., Wells, A., Bodnar, R.J., & Turner, T. (2012). An IP-10 (CXCL10)-derived peptide inhibits angiogenesis. In Proost, P. (Ed.). PLoS One, 7(7), e40812.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0040812.
Kim, H.D., Meyer, A.S., Wagner, J.P., Alford, S.K., Wells, A., Gertler, F.B., & Lauffenburger, D.A. (2011). Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts. Mol Cell Proteomics, 10(11), M111.008433.Elsevier. doi: 10.1074/mcp.M111.008433.
Leloup, L., & Wells, A. (2011). Calpains as potential anti-cancer targets. Expert Opin Ther Targets, 15(3), 309-323.Taylor & Francis. doi: 10.1517/14728222.2011.553611.
Meran, S., Luo, D.D., Simpson, R., Martin, J., Wells, A., Steadman, R., & Phillips, A.O. (2011). Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. J Biol Chem, 286(20), 17618-17630.Elsevier. doi: 10.1074/jbc.M111.226563.
Wells, A., Chao, Y.L., Grahovac, J., Wu, Q., & Lauffenburger, D.A. (2011). Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. Front Biosci (Landmark Ed), 16(3), 815-837.IMR Press. doi: 10.2741/3722.
Wu, S., Wells, A., Griffith, L.G., & Lauffenburger, D.A. (2011). Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling. Biomaterials, 32(30), 7524-7531.Elsevier. doi: 10.1016/j.biomaterials.2011.06.050.
Yates, C.C., Bodnar, R., & Wells, A. (2011). Matrix control of scarring. Cell Mol Life Sci, 68(11), 1871-1881.Springer Nature. doi: 10.1007/s00018-011-0663-0.
Bae, Y.H., Ding, Z., Das, T., Wells, A., Gertler, F., & Roy, P. (2010). Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells. Proc Natl Acad Sci U S A, 107(50), 21547-21552.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1002309107.
Chao, Y.L., Shepard, C.R., & Wells, A. (2010). Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. Mol Cancer, 9(1), 179.Springer Nature. doi: 10.1186/1476-4598-9-179.
Hood, B.L., Grahovac, J., Flint, M.S., Sun, M., Charro, N., Becker, D., Wells, A., & Conrads, T.P. (2010). Proteomic analysis of laser microdissected melanoma cells from skin organ cultures. J Proteome Res, 9(7), 3656-3663.American Chemical Society (ACS). doi: 10.1021/pr100164x.
Krishna, P., Regner, M., Palko, J., Liu, F., Abramowitch, S., Jiang, J., & Wells, A. (2010). The effects of decorin and HGF-primed vocal fold fibroblasts in vitro and ex vivo in a porcine model of vocal fold scarring. Laryngoscope, 120(11), 2247-2257.Wiley. doi: 10.1002/lary.21087.
Leloup, L., Shao, H., Bae, Y.H., Deasy, B., Stolz, D., Roy, P., & Wells, A. (2010). m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate. J Biol Chem, 285(43), 33549-33566.Elsevier. doi: 10.1074/jbc.M110.123604.
Li, M., Aliotta, J.M., Asara, J.M., Wu, Q., Dooner, M.S., Tucker, L.D., Wells, A., Quesenberry, P.J., & Ramratnam, B. (2010). Intercellular transfer of proteins as identified by stable isotope labeling of amino acids in cell culture. J Biol Chem, 285(9), 6285-6297.Elsevier. doi: 10.1074/jbc.M109.057943.
Rodrigues, M., Griffith, L.G., & Wells, A. (2010). Growth factor regulation of proliferation and survival of multipotential stromal cells. Stem Cell Res Ther, 1(4), 32.Springer Nature. doi: 10.1186/scrt32.
Shao, H., Wang, J.H.C., Pollak, M.R., & Wells, A. (2010). α-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts. In Hotchin, N.A. (Ed.). PLoS One, 5(11), e13921.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0013921.
Shao, H., Wu, C., & Wells, A. (2010). Phosphorylation of alpha-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin. J Biol Chem, 285(4), 2591-2600.Elsevier. doi: 10.1074/jbc.M109.035790.
Silver, K., Leloup, L., Freeman, L.C., Wells, A., & Lillich, J.D. (2010). Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease. Int J Biochem Cell Biol, 42(12), 2030-2036.Elsevier. doi: 10.1016/j.biocel.2010.09.007.
Simpson, R.M.L., Wells, A., Thomas, D., Stephens, P., Steadman, R., & Phillips, A. (2010). Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. Am J Pathol, 176(3), 1215-1228.Elsevier. doi: 10.2353/ajpath.2010.090802.
Tamama, K., Kawasaki, H., & Wells, A. (2010). Epidermal growth factor (EGF) treatment on multipotential stromal cells (MSCs). Possible enhancement of therapeutic potential of MSC. J Biomed Biotechnol, 2010(1), 795385.Hindawi. doi: 10.1155/2010/795385.
Wells, A. (2010). Preface. Genetics of neurologic and psychiatric diseases. Clin Lab Med, 30(4), xiii-xiv.Elsevier. doi: 10.1016/j.cll.2010.07.012.
Wells, A., & Leloup, L. (2010). Calpain. In Handbook of Cell Signaling. 2, (pp. 999-1008).Elsevier. doi: 10.1016/b978-0-12-374145-5.00126-1.
Yates, C.C., Krishna, P., Whaley, D., Bodnar, R., Turner, T., & Wells, A. (2010). Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarring. Am J Pathol, 176(4), 1743-1755.Elsevier. doi: 10.2353/ajpath.2010.090564.
Bae, Y.H., Ding, Z., Zou, L., Wells, A., Gertler, F., & Roy, P. (2009). Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins. J Cell Physiol, 219(2), 354-364.Wiley. doi: 10.1002/jcp.21677.
Bodnar, R.J., Yates, C.C., Rodgers, M.E., Du, X., & Wells, A. (2009). IP-10 induces dissociation of newly formed blood vessels. J Cell Sci, 122(Pt 12), 2064-2077.The Company of Biologists. doi: 10.1242/jcs.048793.
Das, T., Bae, Y.H., Wells, A., & Roy, P. (2009). Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells. J Cell Physiol, 218(2), 436-443.Wiley. doi: 10.1002/jcp.21618.
Ding, Z., Gau, D., Deasy, B., Wells, A., & Roy, P. (2009). Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells. Exp Cell Res, 315(17), 2963-2973.Elsevier. doi: 10.1016/j.yexcr.2009.07.004.
Marcantonio, N.A., Boehm, C.A., Rozic, R.J., Au, A., Wells, A., Muschler, G.F., & Griffith, L.G. (2009). The influence of tethered epidermal growth factor on connective tissue progenitor colony formation. Biomaterials, 30(27), 4629-4638.Elsevier. doi: 10.1016/j.biomaterials.2009.05.061.
Platt, M.O., Roman, A.J., Wells, A., Lauffenburger, D.A., & Griffith, L.G. (2009). Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells. J Cell Physiol, 221(2), 306-317.Wiley. doi: 10.1002/jcp.21854.
Platt, M.O., Wilder, C.L., Wells, A., Griffith, L.G., & Lauffenburger, D.A. (2009). Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells. Stem Cells, 27(11), 2804-2814.Oxford University Press (OUP). doi: 10.1002/stem.215.
Yates, C.C., Whaley, D., Hooda, S., Hebda, P.A., Bodnar, R.J., & Wells, A. (2009). Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3. Wound Repair Regen, 17(1), 34-41.Wiley. doi: 10.1111/j.1524-475X.2008.00439.x.
Iyer, A.K.V., Tran, K.T., Griffith, L., & Wells, A. (2008). Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling. J Cell Physiol, 214(2), 504-512.Wiley. doi: 10.1002/jcp.21232.
Kim, H.D., Guo, T.W., Wu, A.P., Wells, A., Gertler, F.B., & Lauffenburger, D.A. (2008). Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. In Schwarzbauer, J.E. (Ed.). Mol Biol Cell, 19(10), 4249-4259.American Society for Cell Biology (ASCB). doi: 10.1091/mbc.e08-05-0501.
Mi, Z., Holmes, F.A., Hellerstedt, B., Pippen, J., Collea, R., Backner, A., Bush, J.E., Gallion, H.H., Wells, A., & O'Shaughnessy, J.A. (2008). Feasibility assessment of a chemoresponse assay to predict pathologic response in neoadjuvant chemotherapy for breast cancer patients. Anticancer Research, 28(3 B), 1733-1740.
Nozawa, H., Howell, G., Suzuki, S., Zhang, Q., Qi, Y., Klein-Seetharaman, J., Wells, A., Grandis, J.R., & Thomas, S.M. (2008). Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion. Clin Cancer Res, 14(13), 4336-4344.American Association for Cancer Research (AACR). doi: 10.1158/1078-0432.CCR-07-4857.
Shao, H., Yi, X.M., & Wells, A. (2008). Epidermal growth factor protects fibroblasts from apoptosis via PI3 kinase and Rac signaling pathways. Wound Repair Regen, 16(4), 551-558.Wiley. doi: 10.1111/j.1524-475X.2008.00402.x.
Sharrow, A.C., Li, Y., Micsenyi, A., Griswold, R.D., Wells, A., Monga, S.S.P., & Blair, H.C. (2008). Modulation of osteoblast gap junction connectivity by serum, TNFalpha, and TRAIL. Exp Cell Res, 314(2), 297-308.Elsevier. doi: 10.1016/j.yexcr.2007.10.010.
Tamama, K., Sen, C.K., & Wells, A. (2008). Differentiation of bone marrow mesenchymal stem cells into the smooth muscle lineage by blocking ERK/MAPK signaling pathway. Stem Cells Dev, 17(5), 897-908.Mary Ann Liebert. doi: 10.1089/scd.2007.0155.
Wells, A., Yates, C., & Shepard, C.R. (2008). E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. Clin Exp Metastasis, 25(6), 621-628.Springer Nature. doi: 10.1007/s10585-008-9167-1.
Yates, C.C., Whaley, D., Y-Chen, A., Kulesekaran, P., Hebda, P.A., & Wells, A. (2008). ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair. Am J Pathol, 173(3), 643-652.Elsevier. doi: 10.2353/ajpath.2008.070990.
Blair, H.C., Wells, A., & Isales, C.M. (2007). Pituitary glycoprotein hormone receptors in non-endocrine organs. Trends Endocrinol Metab, 18(6), 227-233.Elsevier. doi: 10.1016/j.tem.2007.06.001.
Fan, V.H., Tamama, K., Au, A., Littrell, R., Richardson, L.B., Wright, J.W., Wells, A., & Griffith, L.G. (2007). Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells. Stem Cells, 25(5), 1241-1251.Oxford University Press (OUP). doi: 10.1634/stemcells.2006-0320.
Iyer, A.K.V., Tran, K.T., Borysenko, C.W., Cascio, M., Camacho, C.J., Blair, H.C., Bahar, I., & Wells, A. (2007). Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity. J Cell Physiol, 211(3), 748-758.Wiley. doi: 10.1002/jcp.20986.
Joslin, E.J., Opresko, L.K., Wells, A., Wiley, H.S., & Lauffenburger, D.A. (2007). EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. J Cell Sci, 120(Pt 20), 3688-3699.The Company of Biologists. doi: 10.1242/jcs.010488.
Kharait, S., Hautaniemi, S., Wu, S., Iwabu, A., Lauffenburger, D.A., & Wells, A. (2007). Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility. BMC Syst Biol, 1(1), 9.Springer Nature. doi: 10.1186/1752-0509-1-9.
Shepard, C.R., Kassis, J., Whaley, D.L., Kim, H.G., & Wells, A. (2007). PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors. Oncogene, 26(21), 3020-3026.Springer Nature. doi: 10.1038/sj.onc.1210115.
Wells, A. (2007). Calpain. In xPharm: The Comprehensive Pharmacology Reference. (pp. 1-8).Elsevier. doi: 10.1016/b978-008055232-3.60557-4.
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Yaroslavskiy, B.B., Sharrow, A.C., Wells, A., Robinson, L.J., & Blair, H.C. (2007). Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility. J Cell Sci, 120(Pt 16), 2884-2894.The Company of Biologists. doi: 10.1242/jcs.004184.
Yates, C., Shepard, C.R., Papworth, G., Dash, A., Beer Stolz, D., Tannenbaum, S., Griffith, L., & Wells, A. (2007). Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression. Adv Cancer Res, 97, 225-246.Elsevier. doi: 10.1016/S0065-230X(06)97010-9.
Yates, C.C., Shepard, C.R., Stolz, D.B., & Wells, A. (2007). Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin. Br J Cancer, 96(8), 1246-1252.Springer Nature. doi: 10.1038/sj.bjc.6603700.
Yates, C.C., Whaley, D., Babu, R., Zhang, J., Krishna, P., Beckman, E., Pasculle, A.W., & Wells, A. (2007). The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models. Biomaterials, 28(27), 3977-3986.Elsevier. doi: 10.1016/j.biomaterials.2007.05.008.
Yates, C.C., Whaley, D., Kulasekeran, P., Hancock, W.W., Lu, B., Bodnar, R., Newsome, J., Hebda, P.A., & Wells, A. (2007). Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor. Am J Pathol, 171(2), 484-495.Elsevier. doi: 10.2353/ajpath.2007.061092.
Zou, L., Jaramillo, M., Whaley, D., Wells, A., Panchapakesa, V., Das, T., & Roy, P. (2007). Profilin-1 is a negative regulator of mammary carcinoma aggressiveness. Br J Cancer, 97(10), 1361-1371.Springer Nature. doi: 10.1038/sj.bjc.6604038.
Babu, R., Zhang, J., Beckman, E.J., Virji, M., Pasculle, W.A., & Wells, A. (2006). Antimicrobial activities of silver used as a polymerization catalyst for a wound-healing matrix. Biomaterials, 27(24), 4304-4314.Elsevier. doi: 10.1016/j.biomaterials.2006.03.038.
Bodnar, R.J., Yates, C.C., & Wells, A. (2006). IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circ Res, 98(5), 617-625.Wolters Kluwer. doi: 10.1161/01.RES.0000209968.66606.10.
Gallion, H., Christopherson, W.A., Coleman, R.L., DeMars, L., Herzog, T., Hosford, S., Schellhas, H., Wells, A., & Sevin, B.U. (2006). Progression-free interval in ovarian cancer and predictive value of an ex vivo chemoresponse assay. Int J Gynecol Cancer, 16(1), 194-201.Elsevier. doi: 10.1111/j.1525-1438.2006.00301.x.
Kharait, S., Dhir, R., Lauffenburger, D., & Wells, A. (2006). Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells. Biochem Biophys Res Commun, 343(3), 848-856.Elsevier. doi: 10.1016/j.bbrc.2006.03.044.
Krishna, P., Rosen, C.A., Branski, R.C., Wells, A., & Hebda, P.A. (2006). Primed fibroblasts and exogenous decorin: potential treatments for subacute vocal fold scar. Otolaryngol Head Neck Surg, 135(6), 937-945.Wiley. doi: 10.1016/j.otohns.2006.07.011.
Satish, L., Lyons-Weiler, J., Hebda, P.A., & Wells, A. (2006). Gene expression patterns in isolated keloid fibroblasts. Wound Repair Regen, 14(4), 463-470.Wiley. doi: 10.1111/j.1743-6109.2006.00135.x.
Shao, H., Chou, J., Baty, C.J., Burke, N.A., Watkins, S.C., Stolz, D.B., & Wells, A. (2006). Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation. Mol Cell Biol, 26(14), 5481-5496.Taylor & Francis. doi: 10.1128/MCB.02243-05.
Smith, B.R., Wells, A., Alexander, C.B., Bovill, E., Campbell, S., Dasgupta, A., Fung, M., Haller, B., Howe, J.G., Parvin, C., Peerschke, E., Rinder, H., Spitalnik, S., Weiss, R., & Wener, M. (2006). Curriculum content and evaluation of resident competency in clinical pathology (laboratory medicine): a proposal. Clin Chem, 52(6), 917-949.Oxford University Press (OUP). doi: 10.1373/clinchem.2005.066076.
Smith, B.R., Wells, A., Alexander, C.B., Bovill, E., Campbell, S., Dasgupta, A., Fung, M., Haller, B., Howe, J.G., Parvin, C., Peerschke, E., Rinder, H., Spitalnik, S., Weiss, R., Wener, M., & Academy of Clinical Laboratory Physicians and Scientists. (2006). Curriculum content and evaluation of resident competency in clinical pathology (laboratory medicine): a proposal. Hum Pathol, 37(8), 934-968.Elsevier. doi: 10.1016/j.humpath.2006.01.034.
Smith, K.D., Wells, A., & Lauffenburger, D.A. (2006). Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts. Exp Cell Res, 312(11), 1970-1982.Elsevier. doi: 10.1016/j.yexcr.2006.02.022.
Tamama, K., Fan, V.H., Griffith, L.G., Blair, H.C., & Wells, A. (2006). Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. Stem Cells, 24(3), 686-695.Oxford University Press (OUP). doi: 10.1634/stemcells.2005-0176.
Wells, A., & Smith, B. (2006). Counterpoint: developing a clinical pathology curriculum to meet current and future needs. Clin Chem, 52(6), 971-972.Oxford University Press (OUP). doi: 10.1373/clinchem.2006.070540.
Wells, A., Harms, B., Iwabu, A., Koo, L., Smith, K., Griffith, L., & Lauffenburger, D.A. (2006). Motility signaled from the EGF receptor and related systems. Methods Mol Biol, 327, 159-177.Springer Nature. doi: 10.1385/1-59745-012-X:159.
Wells, A., Smith, B.R., & Sacks, D.B. (2006). The challenge of training pathologists in the 21st century. Hum Pathol, 37(8), 932-933.Elsevier. doi: 10.1016/j.humpath.2006.01.033.
Yu, G., Tseng, G.C., Yu, Y.P., Gavel, T., Nelson, J., Wells, A., Michalopoulos, G., Kokkinakis, D., & Luo, J.H. (2006). CSR1 suppresses tumor growth and metastasis of prostate cancer. Am J Pathol, 168(2), 597-607.Elsevier. doi: 10.2353/ajpath.2006.050620.
Zaman, M.H., Trapani, L.M., Sieminski, A.L., Mackellar, D., Gong, H., Kamm, R.D., Wells, A., Lauffenburger, D.A., & Matsudaira, P. (2006). Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A, 103(29), 10889-10894.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0604460103.
Zhou, W., Grandis, J.R., & Wells, A. (2006). STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines. Br J Cancer, 95(2), 164-171.Springer Nature. doi: 10.1038/sj.bjc.6603234.
Hautaniemi, S., Kharait, S., Iwabu, A., Wells, A., & Lauffenburger, D.A. (2005). Modeling of signal-response cascades using decision tree analysis. Bioinformatics, 21(9), 2027-2035.Oxford University Press (OUP). doi: 10.1093/bioinformatics/bti278.
Hendriks, B.S., Orr, G., Wells, A., Wiley, H.S., & Lauffenburger, D.A. (2005). Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells. J Biol Chem, 280(7), 6157-6169.Elsevier. doi: 10.1074/jbc.M410491200.
Lai, S.Y., Childs, E.E., Xi, S., Coppelli, F.M., Gooding, W.E., Wells, A., Ferris, R.L., & Grandis, J.R. (2005). Erratum: Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma. Oncogene, 24(55), 8216.Springer Nature. doi: 10.1038/sj.onc.1209224.
Lai, S.Y., Childs, E.E., Xi, S., Coppelli, F.M., Gooding, W.E., Wells, A., Ferris, R.L., & Grandis, J.R. (2005). Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma. Oncogene, 24(27), 4442-4449.Springer Nature. doi: 10.1038/sj.onc.1208635.
Satish, L., Blair, H.C., Glading, A., & Wells, A. (2005). Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain. Mol Cell Biol, 25(5), 1922-1941.Taylor & Francis. doi: 10.1128/MCB.25.5.1922-1941.2005.
Wang, J., Zhang, X., Thomas, S.M., Grandis, J.R., Wells, A., Chen, Z.G., & Ferris, R.L. (2005). Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR. Oncogene, 24(38), 5897-5904.Springer Nature. doi: 10.1038/sj.onc.1208740.
Wells, A. (2005). EGFR in metastasis. Signal, 6(2), 17-19.
Wells, A., Huttenlocher, A., & Lauffenburger, D.A. (2005). Calpain proteases in cell adhesion and motility. Int Rev Cytol, 245, 1-16.Elsevier. doi: 10.1016/S0074-7696(05)45001-9.
Yates, C., Wells, A., & Turner, T. (2005). Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline. Br J Cancer, 92(2), 366-375.Springer Nature. doi: 10.1038/sj.bjc.6602350.
Glading, A., Bodnar, R.J., Reynolds, I.J., Shiraha, H., Satish, L., Potter, D.A., Blair, H.C., & Wells, A. (2004). Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation (vol 24, pg 2499, 2004). MOLECULAR AND CELLULAR BIOLOGY, 24(13), 6116.Taylor & Francis. doi: 10.1128/MCB.24.13.6116.2004.
Glading, A., Bodnar, R.J., Reynolds, I.J., Shiraha, H., Satish, L., Potter, D.A., Blair, H.C., & Wells, A. (2004). Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation. Mol Cell Biol, 24(6), 2499-2512.Taylor & Francis. doi: 10.1128/MCB.24.6.2499-2512.2004.
Iwabu, A., Smith, K., Allen, F.D., Lauffenburger, D.A., & Wells, A. (2004). Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. J Biol Chem, 279(15), 14551-14560.Elsevier. doi: 10.1074/jbc.M311981200.
Jing, L., Liu, L., Yu, Y.P., Dhir, R., Acquafondada, M., Landsittel, D., Cieply, K., Wells, A., & Luo, J.H. (2004). Expression of myopodin induces suppression of tumor growth and metastasis. Am J Pathol, 164(5), 1799-1806.Elsevier. doi: 10.1016/S0002-9440(10)63738-8.
Kornblith, P., Ochs, R.L., Wells, A., Gabrin, M.J., Piwowar, J., Chattopadhyay, A., George, L.D., & Burholt, D. (2004). Differential in vitro effects of chemotherapeutic agents on primary cultures of human ovarian carcinoma. Int J Gynecol Cancer, 14(4), 607-615.Elsevier. doi: 10.1111/j.1048-891X.2004.14408.x.
Larsen, A.K., De Veyra, T., Jia, Z., Wells, A., Dutt, P., & Elce, J.S. (2004). Expression of human, mouse, and rat m-calpains in Escherichia coli and in murine fibroblasts. Protein Expr Purif, 33(2), 246-255.Elsevier. doi: 10.1016/j.pep.2003.10.005.
Mamoune, A., Kassis, J., Kharait, S., Kloeker, S., Manos, E., Jones, D.A., & Wells, A. (2004). DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling. Exp Cell Res, 299(1), 91-100.Elsevier. doi: 10.1016/j.yexcr.2004.05.008.
Priya, K.S., Arumugam, G., Rathinam, B., Wells, A., & Babu, M. (2004). Celosia argentea Linn. leaf extract improves wound healing in a rat burn wound model. Wound Repair Regen, 12(6), 618-625.Wiley. doi: 10.1111/j.1067-1927.2004.12603.x.
Satish, L., Babu, M., Tran, K.T., Hebda, P.A., & Wells, A. (2004). Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways. Wound Repair Regen, 12(2), 183-192.Wiley. doi: 10.1111/j.1067-1927.2004.012111.x.
Tran, K.T., Griffith, L., & Wells, A. (2004). Extracellular matrix signaling through growth factor receptors during wound healing. Wound Repair Regen, 12(3), 262-268.Wiley. doi: 10.1111/j.1067-1927.2004.012302.x.
Wells, A., & Lillien, L. (2004). Attraction or repulsion: a matter of individual taste?. Sci STKE, 2004(253), pe47.American Association for the Advancement of Science (AAAS). doi: 10.1126/stke.2532004pe47.
Yagi, Y., Ahmed, I., Gross, W., Becich, M.J., Demetris, A.J., Wells, A., Wiley, C.A., Michalopoulos, G.K., Yousem, S.A., Barnes, B., & Gilbertson, J.R. (2004). Webcasting pathology department conferences in a geographically distributed medical center. Hum Pathol, 35(7), 790-797.Elsevier. doi: 10.1016/j.humpath.2004.03.013.
Chou, J., Burke, N.A., Iwabu, A., Watkins, S.C., & Wells, A. (2003). Directional motility induced by epidermal growth factor requires Cdc42. Exp Cell Res, 287(1), 47-56.Elsevier. doi: 10.1016/s0014-4827(03)00119-8.
Hebda, P.A., Whaley, D., Kim, H.G., & Wells, A. (2003). Absence of inhibition of cutaneous wound healing in mice by oral doxycycline. Wound Repair Regen, 11(5), 373-379.Wiley. doi: 10.1046/j.1524-475x.2003.11510.x.
Kornblith, P., Wells, A., Gabrin, M.J., Piwowar, J., Chattopadhyay, A., George, L.D., Ochs, R.L., & Burholt, D. (2003). In vitro responses of ovarian cancers to platinums and taxanes. Anticancer Research, 23(1 B), 543-548.
Kornblith, P., Wells, A., Gabrin, M.J., Piwowar, J., George, L.D., Ochs, R.L., & Burholt, D. (2003). Breast cancer--response rates to chemotherapeutic agents studied in vitro. Anticancer Res, 23(4), 3405-3411.
Lauffenburger, D.A., & Wells, A. (2003). Quantitative parsing of cell multi-tasking in wound repair and tissue morphogenesis. Biophys J, 84(6), 3499-3500.Elsevier. doi: 10.1016/s0006-3495(03)75084-x.
Mamoune, A., Luo, J.H., Lauffenburger, D.A., & Wells, A. (2003). Calpain-2 as a target for limiting prostate cancer invasion. Cancer Res, 63(15), 4632-4640.
Ochs, R.L., Fensterer, J., Ohori, N.P., Wells, A., Gabrin, M., George, L.D., & Kornblith, P. (2003). Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 39(1-2), 63-70. doi: 10.1290/1543-706X(2003)039<0063:EFTIGA>2.0.CO;2.
Ochs, R.L., Fensterer, J., Ohori, N.P., Wells, A., Gabrin, M., George, L.D., & Kornblith, P. (2003). Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors. In Vitro Cell Dev Biol Anim, 39(1-2), 63-70.Springer Nature. doi: 10.1290/1543-706X(2003)039<0063:EFTIGA>2.0.CO;2.
Satish, L., Yager, D., & Wells, A. (2003). Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair. J Invest Dermatol, 120(6), 1110-1117.Elsevier. doi: 10.1046/j.1523-1747.2003.12230.x.
Smith, S.D., Jia, Z., Huynh, K.K., Wells, A., & Elce, J.S. (2003). Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation. FEBS Lett, 542(1-3), 115-118.Wiley. doi: 10.1016/s0014-5793(03)00361-2.
Thomas, S.M., Coppelli, F.M., Wells, A., Gooding, W.E., Song, J., Kassis, J., Drenning, S.D., & Grandis, J.R. (2003). Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma. Cancer Res, 63(17), 5629-5635.
Tran, K.T., Rusu, S.D., Satish, L., & Wells, A. (2003). Aging-related attenuation of EGF receptor signaling is mediated in part by increased protein tyrosine phosphatase activity. Exp Cell Res, 289(2), 359-367.Elsevier. doi: 10.1016/s0014-4827(03)00287-8.
Wells, A., & Grandis, J.R. (2003). Phospholipase C-gamma1 in tumor progression. Clin Exp Metastasis, 20(4), 285-290.Springer Nature. doi: 10.1023/a:1024088922957.
Wells, A., & Huttenlocher, A. (2003). Calpain. In Handbook of Cell Signaling. 2-3, (pp. 105-111).Elsevier. doi: 10.1016/b978-012124546-7/50502-7.
Allen, F.D., Asnes, C.F., Chang, P., Elson, E.L., Lauffenburger, D.A., & Wells, A. (2002). Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation. Wound Repair Regen, 10(1), 67-76.Wiley. doi: 10.1046/j.1524-475x.2002.10701.x.
Chou, J., Stolz, D.B., Burke, N.A., Watkins, S.C., & Wells, A. (2002). Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motility. Int J Biochem Cell Biol, 34(7), 776-790.Elsevier. doi: 10.1016/s1357-2725(01)00177-7.
Glading, A., Lauffenburger, D.A., & Wells, A. (2002). Cutting to the chase: calpain proteases in cell motility. Trends Cell Biol, 12(1), 46-54.Elsevier. doi: 10.1016/s0962-8924(01)02179-1.
Kassis, J., Maeda, A., Teramoto, N., Takada, K., Wu, C., Klein, G., & Wells, A. (2002). EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness. Int J Cancer, 99(5), 644-651.Wiley. doi: 10.1002/ijc.10382.
Kassis, J., Radinsky, R., & Wells, A. (2002). Motility is rate-limiting for invasion of bladder carcinoma cell lines. Int J Biochem Cell Biol, 34(7), 762-775.Elsevier. doi: 10.1016/s1357-2725(01)00173-x.
Shiraha, H., Glading, A., Chou, J., Jia, Z., & Wells, A. (2002). Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain. Mol Cell Biol, 22(8), 2716-2727.Taylor & Francis. doi: 10.1128/MCB.22.8.2716-2727.2002.
Wells, A., & Marti, U. (2002). Signaling shortcuts: cell-surface receptors in the nucleus?. Nature Reviews Molecular Cell Biology, 3(9), 697-6U1.Nature Research (part of Springer Nature). doi: 10.1038/nrm905.
Wells, A., Kassis, J., Solava, J., Turner, T., & Lauffenburger, D.A. (2002). Growth factor-induced cell motility in tumor invasion. Acta Oncol, 41(2), 124-130.MJS Publishing, Medical Journals Sweden AB. doi: 10.1080/028418602753669481.
Wells, A., Kharait, S., Yates, C., & Satish, L. (2002). 19 Calpain proteases in prostate carcinoma. Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas, 2, 463-469.Elsevier. doi: 10.1016/s1874-5784(02)80051-4.
Wells, A., Souto, J.C.S., Solava, J., Kassis, J., Bailey, K.J., & Turner, T. (2002). Luteinizing hormone-releasing hormone agonist limits DU-145 prostate cancer growth by attenuating epidermal growth factor receptor signaling. Clin Cancer Res, 8(4), 1251-1257.
Babu, M., & Wells, A. (2001). Dermal-epidermal communication in wound healing. WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE, 13(5), 183-189.
Barbieri, M.A., Heath, C.M., Peters, E.M., Wells, A., Davis, J.N., & Stahl, P.D. (2001). Phosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosis. J Biol Chem, 276(50), 47212-47216.Elsevier. doi: 10.1074/jbc.C100490200.
Deb, T.B., Su, L., Wong, L., Bonvini, E., Wells, A., David, M., & Johnson, G.R. (2001). Epidermal growth factor (EGF) receptor kinase-independent signaling by EGF. J Biol Chem, 276(18), 15554-15560.Elsevier. doi: 10.1074/jbc.M100928200.
Glading, A., Uberall, F., Keyse, S.M., Lauffenburger, D.A., & Wells, A. (2001). Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling. J Biol Chem, 276(26), 23341-23348.Elsevier. doi: 10.1074/jbc.M008847200.
Kassis, J., Lauffenburger, D.A., Turner, T., & Wells, A. (2001). Tumor invasion as dysregulated cell motility. Semin Cancer Biol, 11(2), 105-117.Elsevier. doi: 10.1006/scbi.2000.0362.
Lauffenburger, D.A., & Wells, A. (2001). Getting a grip: new insights for cell adhesion and traction. Nat Cell Biol, 3(5), E110-E112.Springer Nature. doi: 10.1038/35074631.
Manos, E.J., Kim, M.L., Kassis, J., Chang, P.Y., Wells, A., & Jones, D.A. (2001). Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion. Oncogene, 20(22), 2781-2790.Springer Nature. doi: 10.1038/sj.onc.1204379.
Swindle, C.S., Tran, K.T., Johnson, T.D., Banerjee, P., Mayes, A.M., Griffith, L., & Wells, A. (2001). Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. J Cell Biol, 154(2), 459-468.Rockefeller University Press. doi: 10.1083/jcb.200103103.
Barbieri, M.A., Roberts, R.L., Gumusboga, A., Highfield, H., Alvarez-Dominguez, C., Wells, A., & Stahl, P.D. (2000). Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a. J Cell Biol, 151(3), 539-550.Rockefeller University Press. doi: 10.1083/jcb.151.3.539.
Botelho, R.J., Teruel, M., Dierckman, R., Anderson, R., Wells, A., York, J.D., Meyer, T., & Grinstein, S. (2000). Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J Cell Biol, 151(7), 1353-1368.Rockefeller University Press. doi: 10.1083/jcb.151.7.1353.
Glading, A., Chang, P., Lauffenburger, D.A., & Wells, A. (2000). Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway. J Biol Chem, 275(4), 2390-2398.Elsevier. doi: 10.1074/jbc.275.4.2390.
Haugh, J.M., Wells, A., & Lauffenburger, D.A. (2000). Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions. Biotechnol Bioeng, 70(2), 225-238.Wiley. doi: 10.1002/1097-0290(20001020)70:2<225::aid-bit12>3.0.co;2-s.
Maheshwari, G., Brown, G., Lauffenburger, D.A., Wells, A., & Griffith, L.G. (2000). Cell adhesion and motility depend on nanoscale RGD clustering. J Cell Sci, 113 ( Pt 10)(10), 1677-1686.The Company of Biologists. doi: 10.1242/jcs.113.10.1677.
Marti, U., & Wells, A. (2000). The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires coexpression of a full-length EGFR. Mol Cell Biol Res Commun, 3(1), 8-14.Elsevier. doi: 10.1006/mcbr.2000.0177.
Shiraha, H., Gupta, K., Drabik, K., & Wells, A. (2000). Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors. J Biol Chem, 275(25), 19343-19351.Elsevier. doi: 10.1074/jbc.M000008200.
Wells, A. (2000). Tumor invasion: role of growth factor-induced cell motility. Adv Cancer Res, 78, 31-101.Elsevier. doi: 10.1016/s0065-230x(08)61023-4.
Haugh, J.M., Huang, A.C., Wiley, H.S., Wells, A., & Lauffenburger, D.A. (1999). Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts. J Biol Chem, 274(48), 34350-34360.Elsevier. doi: 10.1074/jbc.274.48.34350.
Haugh, J.M., Schooler, K., Wells, A., Wiley, H.S., & Lauffenburger, D.A. (1999). Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway. J Biol Chem, 274(13), 8958-8965.Elsevier. doi: 10.1074/jbc.274.13.8958.
Kassis, J., Moellinger, J., Lo, H., Greenberg, N.M., Kim, H.G., & Wells, A. (1999). A role for phospholipase C-gamma-mediated signaling in tumor cell invasion. Clin Cancer Res, 5(8), 2251-2260.
Shiraha, H., Glading, A., Gupta, K., & Wells, A. (1999). IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity. J Cell Biol, 146(1), 243-254.Rockefeller University Press. doi: 10.1083/jcb.146.1.243.
Wells, A. (1999). EGF receptor. Int J Biochem Cell Biol, 31(6), 637-643.Elsevier. doi: 10.1016/s1357-2725(99)00015-1.
Wells, A., Ware, M.F., Allen, F.D., & Lauffenburger, D.A. (1999). Shaping up for shipping out: PLCγ signaling of morphology changes in EGF-stimulated fibroblast migration. Cell Motility and the Cytoskeleton, 44(4), 227-233. doi: 10.1002/(SICI)1097-0169(199912)44:4<227::AID-CM1>3.0.CO;2-B.
Wells, A., Ware, M.F., Allen, F.D., & Lauffenburger, D.A. (1999). Shaping up for shipping out: PLCgamma signaling of morphology changes in EGF-stimulated fibroblast migration. Cell Motil Cytoskeleton, 44(4), 227-233.Wiley. doi: 10.1002/(SICI)1097-0169(199912)44:4<227::AID-CM1>3.0.CO;2-B.
Wong, L., Deb, T.B., Thompson, S.A., Wells, A., & Johnson, G.R. (1999). A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling. J Biol Chem, 274(13), 8900-8909.Elsevier. doi: 10.1074/jbc.274.13.8900.
Reddy, C.C., Wells, A., & Lauffenburger, D.A. (1998). Comparative mitogenic potencies of EGF and TGF alpha and their dependence on receptor-limitation versus ligand-limitation. Med Biol Eng Comput, 36(4), 499-507.Springer Nature. doi: 10.1007/BF02523222.
Wells, A., Gupta, K., Chang, P., Swindle, S., Glading, A., & Shiraha, H. (1998). Epidermal growth factor receptor-mediated motility in fibroblasts. Microsc Res Tech, 43(5), 395-411.Wiley. doi: 10.1002/(SICI)1097-0029(19981201)43:5<395::AID-JEMT6>3.0.CO;2-T.
Van Epps-Fung, M., Williford, J., Wells, A., & Hardy, R.W. (1997). Fatty acid-induced insulin resistance in adipocytes. Endocrinology, 138(10), 4338-4345.The Endocrine Society. doi: 10.1210/endo.138.10.5458.
Zhang, M., Wang, M.H., Singh, R.K., Wells, A., & Siegal, G.P. (1997). Epidermal growth factor induces CD44 gene expression through a novel regulatory element in mouse fibroblasts. J Biol Chem, 272(22), 14139-14146.Elsevier. doi: 10.1074/jbc.272.22.14139.
Lowenthal, E.A., Wells, A., Emanuel, P.D., Player, R., & Prchal, J.T. (1996). Sickle cell acute chest syndrome associated with parvovirus B19 infection: case series and review. Am J Hematol, 51(3), 207-213.Wiley. doi: 10.1002/(SICI)1096-8652(199603)51:3<207::AID-AJH5>3.0.CO;2-0.
Reddy, C.C., Niyogi, S.K., Wells, A., Wiley, H.S., & Lauffenburger, D.A. (1996). Engineering epidermal growth factor for enhanced mitogenic potency. Nat Biotechnol, 14(13), 1696-1699.Springer Nature. doi: 10.1038/nbt1296-1696.
Reddy, C.C., Wells, A., & Lauffenburger, D.A. (1996). Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. J Cell Physiol, 166(3), 512-522.Wiley. doi: 10.1002/(SICI)1097-4652(199603)166:3<512::AID-JCP6>3.0.CO;2-S.
Turner, T., Chen, P., Goodly, L.J., & Wells, A. (1996). EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells. Clin Exp Metastasis, 14(4), 409-418.Springer Nature. doi: 10.1007/BF00123400.
Xie, H., Turner, T., Wang, M.H., Singh, R.K., Siegal, G.P., & Wells, A. (1995). In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals. Clin Exp Metastasis, 13(6), 407-419.Springer Nature. doi: 10.1007/BF00118180.
Chen, P., Xie, H., Sekar, M.C., Gupta, K., & Wells, A. (1994). Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement. J Cell Biol, 127(3), 847-857.Rockefeller University Press. doi: 10.1083/jcb.127.3.847.
Reddy, C.C., Wells, A., & Lauffenburger, D.A. (1994). Proliferative response of fibroblasts expressing internalization-deficient epidermal growth factor (EGF) receptors is altered via differential EGF depletion effect. Biotechnol Prog, 10(4), 377-384.Wiley. doi: 10.1021/bp00028a006.
Marti, U., Burwen, S.J., Wells, A., Barker, M.E., Huling, S., Feren, A.M., & Jones, A.L. (1991). Localization of epidermal growth factor receptor in hepatocyte nuclei. Hepatology, 13(1), 15-20.Wolters Kluwer. doi: 10.1016/0270-9139(91)90210-M.
Jønsson, V., Wells, A., & Klein, G. (1982). Receptors for the complement C3d component and the Epstein-Barr virus are quantitatively coexpressed on a series of B-cell lines and their derived somatic cell hybrids. Cell Immunol, 72(2), 263-276.Elsevier. doi: 10.1016/0008-8749(82)90474-9.
Wells, A., Godal, T., Kvaløy, S., Steen, H.B., & Klein, G. (1982). Quantitative comparison of Epstein-Barr virus receptor expression on sIgM and sIgG cell lines and B-cell lymphoma biopsies. Differentiation, 22(2), 113-119.Elsevier. doi: 10.1111/j.1432-0436.1982.tb01234.x.
Koide, N., Wells, A., Klein, G., & Ernberg, I. (1981). Cell surface glycoprotein patterns of two EBV-negative lines and their EBV converted sublines. Intervirology, 16(3), 142-148.Karger Publishers. doi: 10.1159/000149261.
Wells, A., Koide, N., & Klein, G. (1981). Difference in viral binding between two Epstein-Barr virus substrains to a spectrum of receptor-positive target cells. Int J Cancer, 27(3), 303-309.Wiley. doi: 10.1002/ijc.2910270308.
Wells, A., Steen, H.B., Godal, T., & Klein, G. (1981). Epstein-Barr virus receptor expression is correlated to cell cycle phase. J Recept Res, 2(3), 285-298.Taylor & Francis. doi: 10.3109/10799898109038805.
Shao, H., Wang, A., Lauffenburger, D., & Wells, A. (2018). Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain. In Int J Biochem Cell Biol, 95, (pp. 73-84).Elsevier.Netherlands. doi: 10.1016/j.biocel.2017.12.014.
Edington, C.D., Cirit, M., Chen, W.L.K., Clark, A.M., Wells, A., Trumper, D.L., & Griffith, L.G. (2017). Integration of systems biology with organs-on-chips to humanize therapeutic development. In Gray, B.L., & Becker, H. (Eds.). In Proceedings of SPIE--the International Society for Optical Engineering, 10061, (p. 1006113-1006113-9).SPIE, the international society for optics and photonics. doi: 10.1117/12.2256078.
Nguyen, T.V., Kim, E.S., Coppeta, J.R., Wheeler, S.E., Clark, A.M., Lever, A.R., Cirit, M., Yu, J., Spencer, A.J., Sinatra, F.L., Prantil-Baun, R., Wells, A., Griffith, L.G., & Borenstein, J.T. (2014). Automated reagent delivery, media replenishment, and media sampling platform for open cell culture systems. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, (pp. 491-493).
Fan, V.H., Wright, J.W., Wells, A.H., & Griffith, L.G. (2004). Tethered epidermal growth factor as a substrate for bone regeneration. In Transactions - 7th World Biomaterials Congress, (p. 926).
Richardson, L.B., Hess, S.L., Tran, K.T., Wells, A., & Griffith, L.G. (2004). Characterization of cell proliferation and migration in response to PEO-PMMA comb polymer tethered epidermal growth factor. In Transactions - 7th World Biomaterials Congress, (p. 676).
Allen, F.D., Asnes, C.F., Chang, P., Elson, E.L., Lauffenburger, D.A., & Wells, A. (2001). Calpain regulated cell adhesion in EGF-stimulated fibroblast-populated-collagen-lattice contraction. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, 50, (pp. 353-354).
Lauffenburger, D.A., Chu, L., French, A., Oehrtman, G., Reddy, C., Wells, A., Niyogi, S., & Wiley, H.S. (1996). Engineering dynamics of growth factors and other therapeutic ligands. In Biotechnol Bioeng, 52(1), (pp. 61-80).Wiley.United States. doi: 10.1002/(SICI)1097-0290(19961005)52:1<61::AID-BIT6>3.0.CO;2-X.