headshot

Steven Little

Professor
Distinguished Professor and Department Chair
Little Lab @think_little @ChemePitt Linkedin Bioengineering Department

overview

Dr. Steven Little is a Distinguished Professor and the William Kepler Whiteford Endowed Professor of Chemical and Petroleum Engineering, Bioengineering, Pharmaceutical Sciences, Immunology, Ophthalmology and the McGowan Institute for Regenerative Medicine at the University of Pittsburgh. He received his PhD in Chemical Engineering from MIT in 2005, with his thesis winning the American Association for Advancement of Science's Excellence in Research Award. Dr. Little's research has resulted to date in over 89 peer reviewed publications; 3 book chapters; 4 US patents, 3 US patents pending and the founding of two spin-out companies located in Pittsburgh, PA. Dr. Little has delivered 62 invited talks including 6 plenary presentations and 5 keynote presentations. Dr. Little has been recognized by national and international awards including the Curtis W. McGraw Research Award from the ASEE, being elected as a fellow of BMES and AIMBE, a Carnegie Science Award for Research, the Society for Biomaterials' Young Investigator Award, the University of Pittsburgh's Chancellor's Distinguished Research Award, being named a Camille Dreyfus Teacher Scholar, being named an Arnold and Mabel Beckman Young Investigator, and being elected to the Board of Directors of the Society for Biomaterials. In addition, Dr. Little's exceptional teaching and leadership in education have also been recognized by both the University of Pittsburgh's Chancellor's Distinguished Teaching Award and a 2nd Carnegie Science Award for Post-Secondary Education. Dr. Little was also recently named one of Pittsburgh Magazine's 40 under 40, a "Fast Tracker" by the Pittsburgh Business Times, and also one of only five individuals in Pittsburgh who are "reshaping our world" by Pop City Media. Dr. Little currently serves as the 12th Chairman of the Department of Chemical and Petroleum Engineering.

about

(2015) Named "Fellow of the University Honors College", University of Pittsburgh.

(2015) The Carnegie Science Award in the Category of Advanced Materials.

(2015) Curtis W. McGraw Research Award - American Society for Engineering Education.

(2014) Institute for Clinical Research Distinguished Alumni Award.

(2014) Named One of Five Pittsburgh "Disruptors" Who are "Shaking Up the Status Quo and Reshaping Our World" by Pop City Pittsburgh.

(2014) Selected as one of Pittsburgh Magazine's "40 under 40".

(2014) Phase II Coulter Translational Research Award.

(2014) Research to Prevent Blindness - Innovative Ophthalmic Research Award.

(2013) Chancellors Distinguished Teaching Award.

(2013) Carnegie Science Award in the Category of University Educator.

(2012) Best Diversity Mentor Award.

(2012) Invited Participant, NAE's Frontiers of Engineering Symposium.

(2012) Chancellor's Distinguished Research Award.

(2012) Society for Biomaterials Young Investigator Award.

(2012) Pitt Innovator Award.

(2012) Camille Dreyfus Teacher-Scholar.

(2010) Phase I Coulter Translational Research Award.

(2010) Most Outstanding Young Alumni.

(2009) Board of Visitor's Award - Most Outstanding Faculty Member in the School of Engineering.

(2009) Distinguished Faculty Fellowship.

(2008) Beckman Foundation Young Investigator Award.

(2008) ICRE Award.

(2007) AHA Career Development Award.

(2007) Distinguished Faculty Fellowship.

(2007) NIH K-Award.

(2005) AAAS Excellence in Research Award.

(2000 - 2003) National Science Foundation Graduate Fellow.

(2000) Tau Beta Pi Graduate Fellow.

(2000) Phi Kappa Phi Mavrigian-Grim Graduate Fellow.

(1999) ACS Organic Chemistry Award.

(1999) AIChE Professional Promise Award.

(1999) Eugene D. Scudder Physical Chemistry Award.

PhD, Chemical Engineering, Massachusetts Institute of Technology, 2005

BS, Chemical Engineering, Youngstown State University, 2000

Acharya, A.P., Tang, Y., Bertero, T., Tai, Y.Y., Harvey, L.D., Woodcock, C.S.C., Sun, W., Pineda, R., Mitash, N., Konigshoff, M., Little, S.R., & Chan, S.Y. (2021). Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(12), e019091.Ovid Technologies (Wolters Kluwer Health). doi: 10.1161/JAHA.120.019091.

Bassin, E.J., Piganelli, J.D., & Little, S.R. (2021). Auto-antigen and Immunomodulatory Agent-Based Approaches for Antigen-Specific Tolerance in NOD Mice. CURRENT DIABETES REPORTS, 21(3), 9.Springer Science and Business Media LLC. doi: 10.1007/s11892-021-01376-6.

Bellotti, E., Schilling, A.L., Little, S.R., & Decuzzi, P. (2021). Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: A review. JOURNAL OF CONTROLLED RELEASE, 329, 16-35.Elsevier BV. doi: 10.1016/j.jconrel.2020.11.049.

Bentley, E.R., & Little, S.R. (2021). Local delivery strategies to restore immune homeostasis in the context of inflammation. ADVANCED DRUG DELIVERY REVIEWS, 178, 113971.Elsevier BV. doi: 10.1016/j.addr.2021.113971.

Borrelli, M.A., Turnquist, H.R., & Little, S.R. (2021). Biologics and their delivery systems: Trends in myocardial infarction. ADVANCED DRUG DELIVERY REVIEWS, 173, 181-215.Elsevier BV. doi: 10.1016/j.addr.2021.03.014.

Greene, A.C., Acharya, A.P., Lee, S.B., Gottardi, R., Zaleski, E., & Little, S.R. (2021). Cranberry extract-based formulations for preventing bacterial biofilms. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 11(3), 1144-1155.Springer Science and Business Media LLC. doi: 10.1007/s13346-020-00837-x.

Lorentz, K.L., Gupta, P., Shehabeldin, M.S., Cunnane, E.M., Ramaswamy, A.K., Verdelis, K., Dileo, M.V., Little, S.R., Weinbaum, J.S., Sfeir, C.S., Mandal, B.B., & Vorp, D.A. (2021). CCL2 loaded microparticles promote acute patency in silk-based vascular grafts implanted in rat aortae. ACTA BIOMATERIALIA, 135, 126-138.Elsevier BV. doi: 10.1016/j.actbio.2021.08.049.

Pacheco, C.M.F., Maltos, K.L.M., Shehabeldin, M.S., Thomas, L.L., Zhuang, Z., Yoshizawa, S., Verdelis, K., Gaffen, S.L., Garlet, G.P., Little, S.R., & Sfeir, C. (2021). Local Sustained Delivery of Anti-IL-17A Antibodies Limits Inflammatory Bone Loss in Murine Experimental Periodontitis. JOURNAL OF IMMUNOLOGY, 206(10), 2386-2392.The American Association of Immunologists. doi: 10.4049/jimmunol.2001432.

Patel, S.K., Greene, A.C., Desai, S.M., Rothstein, S., Basha, I.T., MacPherson, J.S., Wang, Y., Zou, Y., Shehabeldin, M., Sfeir, C.S., Little, S.R., & Rohan, L.C. (2021). Biorelevant and screening dissolution methods for minocycline hydrochloride microspheres intended for periodontal administration. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 596, 120261.Elsevier BV. doi: 10.1016/j.ijpharm.2021.120261.

Schilling, A.L., Cannon, E., Fullerton-Shirey, S.K., Lee, S.E., Wang, E.W., & Little, S.R. (2021). A ready-to-use, thermoresponsive, and extended-release delivery system for the paranasal sinuses. DRUG DELIVERY AND TRANSLATIONAL RESEARCH.Springer Science and Business Media LLC. doi: 10.1007/s13346-021-01069-3.

Schilling, A.L., Carcella, A.R., Moore, J., Zahid, M., Lo, C., Wang, E.W., Lee, S.E., & Little, S.R. (2021). Compatibility of a Thermoresponsive and Controlled Release System for Promoting Sinonasal Cilia Regeneration. MACROMOLECULAR BIOSCIENCE, 21(11), e2100277.Wiley. doi: 10.1002/mabi.202100277.

Schilling, A.L., Kulahci, Y., Moore, J., Wang, E.W., Lee, S.E., & Little, S.R. (2021). A thermoresponsive hydrogel system for long-acting corticosteroid delivery into the paranasal sinuses. JOURNAL OF CONTROLLED RELEASE, 330, 889-897.Elsevier BV. doi: 10.1016/j.jconrel.2020.10.062.

Schilling, A.L., Little, S.R., Wang, E.W., & Lee, S.E. (2021). Reply: A preclinical model to tackle chronic rhinosinusitis. INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 11(4), 828-829.Wiley. doi: 10.1002/alr.22769.

Schilling, A.L., Moore, J., Kulahci, Y., Little, S.R., Vmd, L.H.R., Wang, E.W., & Lee, S.E. (2021). Evaluating inflammation in an obstruction-based chronic rhinosinusitis model in rabbits. INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 11(4), 807-809.Wiley. doi: 10.1002/alr.22729.

Yonet-Tanyeri, N., Ahlmark, B.Z., & Little, S.R. (2021). Advances in Multiplexed Paper-Based Analytical Devices for Cancer Diagnosis: A Review of Technological Developments. ADVANCED MATERIALS TECHNOLOGIES, 6(8), 2001138.Wiley. doi: 10.1002/admt.202001138.

Bassin, E.J., Buckley, A.R., Piganelli, J.D., & Little, S.R. (2020). TRI microparticles prevent inflammatory arthritis in a collagen-induced arthritis model. PLOS ONE, 15(9), e0239396.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0239396.

Ding, X., Gao, J., Acharya, A.P., Wu, Y.L., Little, S.R., & Wang, Y. (2020). Azido-Functionalized Polyurethane Designed for Making Tunable Elastomers by Click Chemistry. ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(2), 852-864.American Chemical Society (ACS). doi: 10.1021/acsbiomaterials.9b01357.

Fisher, J.D., Zhang, W., Balmert, S.C., Aral, A.M., Acharya, A.P., Kulahci, Y., Li, J., Turnquist, H.R., Thomson, A.W., Solari, M.G., Gorantla, V.S., & Little, S.R. (2020). In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation. SCIENCE ADVANCES, 6(11), eaax8429.American Association for the Advancement of Science (AAAS). doi: 10.1126/sciadv.aax8429.

Sarmento, B., & Little, S. (2020). Fundamentals of nanomedicines towards clinical translation. Drug Deliv Transl Res, 10(3), 571.Springer Science and Business Media LLC. doi: 10.1007/s13346-020-00762-z.

Bellotti, E., Fedorchak, M.V., Velankar, S., & Little, S.R. (2019). Tuning of thermoresponsive pNIPAAm hydrogels for the topical retention of controlled release ocular therapeutics. JOURNAL OF MATERIALS CHEMISTRY B, 7(8), 1276-1283.Royal Society of Chemistry (RSC). doi: 10.1039/c8tb02976h.

de Campos Soriani Azevedo, M., Garlet, T.P., Francisconi, C.F., Colavite, P.M., Tabanez, A.P., Melchiades, J.L., Favaro Trombone, A.P., Sfeir, C., Little, S., Silva, R.M., & Garlet, G.P. (2019). Vasoactive Intestinal Peptide Immunoregulatory Role at the Periapex: Associative and Mechanistic Evidences from Human and Experimental Periapical Lesions. J Endod, 45(10), 1228-1236.Elsevier BV. doi: 10.1016/j.joen.2019.06.013.

Fisher, J.D., Balmert, S.C., Zhang, W., Schweizer, R., Schnider, J.T., Komatsu, C., Dong, L., Erbas, V.E., Unadkat, J.V., Aral, A.M., Acharya, A.P., Kulahci, Y., Turnquist, H.R., Thomson, A.W., Solari, M.G., Gorantla, V.S., & Little, S.R. (2019). Treg-inducing microparticles promote donor-specific tolerance in experimental vascularized composite allotransplantation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(51), 25784-25789.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1910701116.

Joseph, N., Lawson, H.D., Overholt, K.J., Damodaran, K., Gottardi, R., Acharya, A.P., & Little, S.R. (2019). Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications. SCIENTIFIC REPORTS, 9(1), 13024.Springer Science and Business Media LLC. doi: 10.1038/s41598-019-49536-9.

Leong, H.S., Butler, K.S., Brinker, C.J., Azzawi, M., Conlan, S., Dufes, C., Owen, A., Rannard, S., Scott, C., Chen, C., Dobrovolskaia, M.A., Kozlov, S.V., Prina-Mello, A., Schmid, R., Wick, P., Caputo, F., Boisseau, P., Crist, R.M., McNeil, S.E., Fadeel, B., Tran, L., Hansen, S.F., Hartmann, N.B., Clausen, L.P.W., Skjolding, L.M., Baun, A., Agerstrand, M., Gu, Z., Lamprou, D.A., Hoskins, C., Huang, L., Song, W., Cao, H., Liu, X., Jandt, K.D., Jiang, W., Kim, B.Y.S., Wheeler, K.E., Chetwynd, A.J., Lynch, I., Moghimi, S.M., Nel, A., Xia, T., Weiss, P.S., Sarmento, B., das Neves, J., Santos, H.A., Santos, L., Mitragotri, S., Little, S., Peer, D., Amiji, M.M., Alonso, M.J., Petri-Fink, A., Balog, S., Lee, A., Drasler, B., Rothen-Rutishauser, B., Wilhelm, S., Acar, H., Harrison, R.G., Mao, C., Mukherjee, P., Ramesh, R., McNally, L.R., Busatto, S., Wolfram, J., Bergese, P., Ferrari, M., Fang, R.H., Zhang, L., Zheng, J., Peng, C., Du, B., Yu, M., Charron, D.M., Zheng, G., & Pastore, C. (2019). On the issue of transparency and reproducibility in nanomedicine. NATURE NANOTECHNOLOGY, 14(7), 629-635.Springer Science and Business Media LLC. doi: 10.1038/s41565-019-0496-9.

Leong, H.S., Butler, K.S., Brinker, C.J., Azzawi, M., Conlan, S., Dufès, C., Owen, A., Rannard, S., Scott, C., Chen, C., Dobrovolskaia, M.A., Kozlov, S.V., Prina-Mello, A., Schmid, R., Wick, P., Caputo, F., Boisseau, P., Crist, R.M., McNeil, S.E., Fadeel, B., Tran, L., Hansen, S.F., Hartmann, N.B., Clausen, L.P.W., Skjolding, L.M., Baun, A., Ågerstrand, M., Gu, Z., Lamprou, D.A., Hoskins, C., Huang, L., Song, W., Cao, H., Liu, X., Jandt, K.D., Jiang, W., Kim, B.Y.S., Wheeler, K.E., Chetwynd, A.J., Lynch, I., Moghimi, S.M., Nel, A., Xia, T., Weiss, P.S., Sarmento, B., das Neves, J., Santos, H.A., Santos, L., Mitragotri, S., Little, S., Peer, D., Amiji, M.M., Alonso, M.J., Petri-Fink, A., Balog, S., Lee, A., Drasler, B., Rothen-Rutishauser, B., Wilhelm, S., Acar, H., Harrison, R.G., Mao, C., Mukherjee, P., Ramesh, R., McNally, L.R., Busatto, S., Wolfram, J., Bergese, P., Ferrari, M., Fang, R.H., Zhang, L., Zheng, J., Peng, C., Du, B., Yu, M., Charron, D.M., Zheng, G., & Pastore, C. (2019). Publisher Correction: On the issue of transparency and reproducibility in nanomedicine. Nat Nanotechnol, 14(9), 902.Springer Science and Business Media LLC. doi: 10.1038/s41565-019-0538-3.

Leong, H.S., Butler, K.S., Brinker, C.J., Azzawi, M., Conlan, S., Dufès, C., Owen, A., Rannard, S., Scott, C., Chen, C., Dobrovolskaia, M.A., Kozlov, S.V., Prina-Mello, A., Schmid, R., Wick, P., Caputo, F., Boisseau, P., Crist, R.M., McNeil, S.E., Fadeel, B., Tran, L., Hansen, S.F., Hartmann, N.B., Clausen, L.P.W., Skjolding, L.M., Baun, A., Ågerstrand, M., Gu, Z., Lamprou, D.A., Hoskins, C., Huang, L., Song, W., Cao, H., Liu, X., Jandt, K.D., Jiang, W., Kim, B.Y.S., Wheeler, K.E., Chetwynd, A.J., Lynch, I., Moghimi, S.M., Nel, A., Xia, T., Weiss, P.S., Sarmento, B., Neves, J.D., Santos, H.A., Santos, L., Mitragotri, S., Little, S., Peer, D., Amiji, M.M., Alonso, M.J., Petri-Fink, A., Balog, S., Lee, A., Drasler, B., Rothen-Rutishauser, B., Wilhelm, S., Acar, H., Harrison, R.G., Mao, C., Mukherjee, P., Ramesh, R., McNally, L.R., Busatto, S., Wolfram, J., Bergese, P., Ferrari, M., Fang, R.H., Zhang, L., Zheng, J., Peng, C., Du, B., Yu, M., Charron, D.M., Zheng, G., & Pastore, C. (2019). Publisher Correction: On the issue of transparency and reproducibility in nanomedicine. Nat Nanotechnol, 14(8), 811.Springer Science and Business Media LLC. doi: 10.1038/s41565-019-0523-x.

Little, S.R. (2019). The current status and future directions of CRS Focus Groups. JOURNAL OF CONTROLLED RELEASE, 300, 46-51.Elsevier BV. doi: 10.1016/j.jconrel.2019.02.020.

Zhuang, Z., Yoshizawa-Smith, S., Glowacki, A., Maltos, K., Pacheco, C., Shehabeldin, M., Mulkeen, M., Myers, N., Chong, R., Verdelis, K., Garlet, G.P., Little, S., & Sfeir, C. (2019). Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models. JOURNAL OF DENTAL RESEARCH, 98(2), 200-208.SAGE Publications. doi: 10.1177/0022034518805984.

Francisconi, C.F., Vieira, A.E., Azevedo, M.C.S., Tabanez, A.P., Fonseca, A.C., Trombone, A.P.F., Letra, A., Silva, R.M., Sfeir, C.S., Little, S.R., & Garlet, G.P. (2018). RANKL Triggers Treg-Mediated Immunoregulation in Inflammatory Osteolysis. JOURNAL OF DENTAL RESEARCH, 97(8), 917-927.SAGE Publications. doi: 10.1177/0022034518759302.

Fuller, T.W., Acharya, A.P., Meyyappan, T., Yu, M., Bhaskar, G., Little, S.R., & Tarin, T.V. (2018). Comparison of Bladder Carcinogens in the Urine of E-cigarette Users Versus Non E-cigarette Using Controls. SCIENTIFIC REPORTS, 8(1), 507.Springer Science and Business Media LLC. doi: 10.1038/s41598-017-19030-1.

Hwang, M.P., Ding, X., Gao, J., Acharya, A.P., Little, S.R., & Wang, Y. (2018). A biocompatible betaine-functionalized polycation for coacervation. SOFT MATTER, 14(3), 387-395.Royal Society of Chemistry (RSC). doi: 10.1039/c7sm01763d.

Nichols, D.A., Sondh, I.S., Little, S.R., Zunino, P., & Gottardi, R. (2018). Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis (vol 20, 18, 2018). BIOMEDICAL MICRODEVICES, 20(2), 39.Springer Science and Business Media LLC. doi: 10.1007/s10544-018-0283-7.

Nichols, D.A., Sondh, I.S., Little, S.R., Zunino, P., & Gottardi, R. (2018). Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis. Biomed Microdevices, 20(1), 18.Springer Science and Business Media LLC. doi: 10.1007/s10544-018-0264-x.

Ratay, M.L., Balmert, S.C., Bassin, E.J., & Little, S.R. (2018). Controlled release of an HDAC inhibitor for reduction of inflammation in dry eye disease. ACTA BIOMATERIALIA, 71, 261-270.Elsevier BV. doi: 10.1016/j.actbio.2018.03.002.

Washington, M.A., Balmert, S.C., Fedorchak, M.V., Little, S.R., Watkins, S.C., & Meyer, T.Y. (2018). Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response. ACTA BIOMATERIALIA, 65, 259-271.Elsevier BV. doi: 10.1016/j.actbio.2017.10.043.

Acharya, A.P., Sinha, M., Ratay, M.L., Ding, X., Balmert, S.C., Workman, C.J., Wang, Y., Vignali, D.A.A., & Little, S.R. (2017). Localized Multi-Component Delivery Platform Generates Local and Systemic Anti-Tumor Immunity. ADVANCED FUNCTIONAL MATERIALS, 27(5), 1604366.Wiley. doi: 10.1002/adfm.201604366.

Acharya, A.P., Theisen, K.M., Correa, A., Meyyappan, T., Apfel, A., Sun, T., Tarin, T.V., & Little, S.R. (2017). An Inexpensive, Point-of-Care Urine Test for Bladder Cancer in Patients Undergoing Hematuria Evaluation. ADVANCED HEALTHCARE MATERIALS, 6(22), 1700808.Wiley. doi: 10.1002/adhm.201700808.

Balmert, S.C., Donahue, C., Vu, J.R., Erdos, G., Jr, F.L.D., & Little, S.R. (2017). In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis. JOURNAL OF CONTROLLED RELEASE, 261, 223-233.Elsevier BV. doi: 10.1016/j.jconrel.2017.07.006.

Bayer, E.A., Jordan, J., Roy, A., Gottardi, R., Fedorchak, M.V., Kumta, P.N., & Little, S.R. (2017). Programmed Platelet-Derived Growth Factor-BB and Bone Morphogenetic Protein-2 Delivery from a Hybrid Calcium Phosphate/Alginate Scaffold. TISSUE ENGINEERING PART A, 23(23-24), 1382-1393.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2017.0027.

Fedorchak, M.V., Conner, I.P., Schuman, J.S., Cugini, A., & Little, S.R. (2017). Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop. SCIENTIFIC REPORTS, 7(1), 8639.Springer Science and Business Media LLC. doi: 10.1038/s41598-017-09379-8.

Ratay, M.L., Balmert, S.C., Acharya, A.P., Greene, A.C., Meyyappan, T., & Little, S.R. (2017). TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model. SCIENTIFIC REPORTS, 7(1), 17527.Springer Science and Business Media LLC. doi: 10.1038/s41598-017-17869-y.

Ratay, M.L., Bellotti, E., Gottardi, R., & Little, S.R. (2017). Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation. ADVANCED HEALTHCARE MATERIALS, 6(23), 1700733.Wiley. doi: 10.1002/adhm.201700733.

Ratay, M.L., Glowacki, A.J., Balmert, S.C., Acharya, A.P., Polat, J., Andrews, L.P., Fedorchak, M.V., Schuman, J.S., Vignali, D.A.A., & Little, S.R. (2017). Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease. JOURNAL OF CONTROLLED RELEASE, 258, 208-217.Elsevier BV. doi: 10.1016/j.jconrel.2017.05.007.

Washington, M.A., Swiner, D.J., Bell, K.R., Fedorchak, M.V., Little, S.R., & Meyer, T.Y. (2017). The impact of monomer sequence and stereochemistry on the swelling and erosion of biodegradable poly(lactic-co-glycolic acid) matrices. BIOMATERIALS, 117, 66-76.Elsevier BV. doi: 10.1016/j.biomaterials.2016.11.037.

Bayer, E.A., Fedorchak, M.V., & Little, S.R. (2016). The Influence of Platelet-Derived Growth Factor and Bone Morphogenetic Protein Presentation on Tubule Organization by Human Umbilical Vascular Endothelial Cells and Human Mesenchymal Stem Cells in Coculture. TISSUE ENGINEERING PART A, 22(21-22), 1296-1304.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2016.0163.

Francisconi, C.F., Vieira, A.E., Biguetti, C.C., Glowacki, A.J., Favaro Trombone, A.P., Letra, A., Silva, R.M., Sfeir, C.S., Little, S.R., & Garlet, G.P. (2016). Characterization of the Protective Role of Regulatory T Cells in Experimental Periapical Lesion Development and Their Chemoattraction Manipulation as a Therapeutic Tool. JOURNAL OF ENDODONTICS, 42(1), 120-126.Elsevier BV. doi: 10.1016/j.joen.2015.09.022.

Roy, A., Jhunjhunwala, S., Bayer, E., Fedorchak, M., Little, S.R., & Kumta, P.N. (2016). Porous calcium phosphate-poly (lactic-co-glycolic) acid composite bone cement: A viable tunable drug delivery system. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 59, 92-101.Elsevier BV. doi: 10.1016/j.msec.2015.09.081.

Acharya, A.P., & Little, S.R. (2015). Stapled endosome disrupting alginate particles for cytosolic delivery of cations. JOURNAL OF DRUG TARGETING, 23(7-8), 690-697.Informa UK Limited. doi: 10.3109/1061186X.2015.1048517.

Araujo-Pires, A.C., Vieira, A.E., Francisconi, C.F., Biguetti, C.C., Glowacki, A., Yoshizawa, S., Campanelli, A.P., Favaro Trombone, A.P., Sfeir, C.S., Little, S.R., & Garlet, G.P. (2015). IL-4/CCL22/CCR4 Axis Controls Regulatory T-Cell Migration That Suppresses Inflammatory Bone Loss in Murine Experimental Periodontitis. JOURNAL OF BONE AND MINERAL RESEARCH, 30(3), 400-410.Wiley. doi: 10.1002/jbmr.2376.

Balmert, S.C., Zmolek, A.C., Glowacki, A.J., Knab, T.D., Rothstein, S.N., Wokpetah, J.M., Fedorchak, M.V., & Little, S.R. (2015). Positive charge of "sticky'' peptides and proteins impedes release from negatively charged PLGA matrices. JOURNAL OF MATERIALS CHEMISTRY B, 3(23), 4723-4734.Royal Society of Chemistry (RSC). doi: 10.1039/c5tb00515a.

Bayer, E.A., Gottardi, R., Fedorchak, M.V., & Little, S.R. (2015). The scope and sequence of growth factor delivery for vascularized bone tissue regeneration. JOURNAL OF CONTROLLED RELEASE, 219, 129-140.Elsevier BV. doi: 10.1016/j.jconrel.2015.08.004.

Fisher, J.D., Acharya, A.P., & Little, S.R. (2015). Micro and nanoparticle drug delivery systems for preventing allotransplant rejection. CLINICAL IMMUNOLOGY, 160(1), 24-35.Elsevier BV. doi: 10.1016/j.clim.2015.04.013.

Glowacki, A.J., Gottardi, R., Yoshizawa, S., Cavalla, F., Garlet, G.P., Sfeir, C., & Little, S.R. (2015). Strategies to Direct the Enrichment, Expansion, and Recruitment of Regulatory Cells for the Treatment of Disease. ANNALS OF BIOMEDICAL ENGINEERING, 43(3), 593-602.Springer Science and Business Media LLC. doi: 10.1007/s10439-014-1125-2.

Guaragno, M.L., Gottardi, R., Fedorchak, M.V., Roy, A., Kumta, P.N., & Little, S.R. (2015). One-step synthesis of fluorescentty labelled, single-walled carbon nanotubes. CHEMICAL COMMUNICATIONS, 51(97), 17233-17236.Royal Society of Chemistry (RSC). doi: 10.1039/c5cc05573c.

Knab, T.D., Little, S.R., & Parker, R.S. (2015). A systems approach to modeling drug release from polymer microspheres to accelerate in vitro to in vivo translation. JOURNAL OF CONTROLLED RELEASE, 211, 74-84.Elsevier BV. doi: 10.1016/j.jconrel.2015.04.045.

Lash, M.H., Fedorchak, M.V., Little, S.R., & McCarthy, J.J. (2015). Fabrication and Characterization of Non-Brownian Particle-Based Crystals. LANGMUIR, 31(3), 898-905.American Chemical Society (ACS). doi: 10.1021/la501511s.

Lash, M.H., Fedorchak, M.V., McCarthy, J.J., & Little, S.R. (2015). Scaling up self-assembly: bottom-up approaches to macroscopic particle organization. SOFT MATTER, 11(28), 5597-5609.Royal Society of Chemistry (RSC). doi: 10.1039/c5sm00764j.

Lash, M.H., Jordan, J.C., Blevins, L.C., Fedorchak, M.V., Little, S.R., & McCarthy, J.J. (2015). Non-Brownian Particle-Based Materials with Microscale and Nanoscale Hierarchy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(20), 5853-5858.Wiley. doi: 10.1002/anie.201500273.

Lash, M.H., Jordan, J.C., Blevins, L.C., Fedorchak, M.V., Little, S.R., & McCarthy, J.J. (2015). Non-Brownian Particle-Based Materials with Microscale and Nanoscale Hierarchy. Angewandte Chemie, 127(20), 5952-5956.Wiley. doi: 10.1002/ange.201500273.

Fedorchak, M.V., Conner, I.P., Medina, C.A., Wingard, J.B., Schuman, J.S., & Little, S.R. (2014). 28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres. EXPERIMENTAL EYE RESEARCH, 125, 210-216.Elsevier BV. doi: 10.1016/j.exer.2014.06.013.

Fu, H.L., Hong, Y., Little, S.R., & Wagner, W.R. (2014). Collagenase-Labile Polyurethane Urea Synthesis and Processing into Hollow Fiber Membranes. BIOMACROMOLECULES, 15(8), 2924-2932.American Chemical Society (ACS). doi: 10.1021/bm500552f.

Garlet, G.P., Sfeir, C.S., & Little, S.R. (2014). Restoring Host-Microbe Homeostasis via Selective Chemoattraction of Tregs. JOURNAL OF DENTAL RESEARCH, 93(9), 834-839.SAGE Publications. doi: 10.1177/0022034514544300.

Mealy, J.E., Fedorchak, M.V., & Little, S.R. (2014). In vitro characterization of a controlled-release ocular insert for delivery of brimonidine tartrate. ACTA BIOMATERIALIA, 10(1), 87-93.Elsevier BV. doi: 10.1016/j.actbio.2013.09.024.

Rothstein, S.N., Donahue, C., Jr, F.L.D., & Little, S.R. (2014). In silico programming of degradable microparticles to hide and then reveal immunogenic payloads in vivo. JOURNAL OF MATERIALS CHEMISTRY B, 2(37), 6183-6187.Royal Society of Chemistry (RSC). doi: 10.1039/c4tb01042f.

Rothstein, S.N., Huber, K.D., Siuis-Cremer, N., & Little, S.R. (2014). In Vitro Characterization of a Sustained-Release Formulation for Enfuvirtide. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(3), 1797-1799.American Society for Microbiology. doi: 10.1128/AAC.02440-13.

Fedorchak, M., Cugini, A., Schuman, J., & Little, S. (2013). The Monthly Eye Drop: Development of a Long-term, Noninvasive Glaucoma Treatment System. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(15), 4294.

Glowacki, A.J., Yoshizawa, S., Jhunjhunwala, S., Vieira, A.E., Garlet, G.P., Sfeir, C., & Little, S.R. (2013). Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(46), 18525-18530.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1302829110.

Jhunjhunwala, S., Chen, L.C., Nichols, E.E., Thomson, A.W., Raimondi, G., & Little, S.R. (2013). All-trans retinoic acid and rapamycin synergize with transforming growth factor-beta 1 to induce regulatory T cells but confer different migratory capacities. JOURNAL OF LEUKOCYTE BIOLOGY, 94(5), 981-989.Wiley. doi: 10.1189/jlb.0312167.

Kamalasanan, K., Gottardi, R., Tan, S., Chen, Y., Godugu, B., Rothstein, S., Balazs, A.C., Star, A., & Little, S.R. (2013). "Zero-Dimensional" Single-Walled Carbon Nanotubes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(43), 11308-11312.Wiley. doi: 10.1002/anie.201305526.

Little, S. (2013). Foreword. 9781118098479, xi-xii.

Balmert, S.C., & Little, S.R. (2012). Biomimetic Delivery with Micro- and Nanoparticles. ADVANCED MATERIALS, 24(28), 3757-3778.Wiley. doi: 10.1002/adma.201200224.

Eghtesad, S., Jhunjhunwala, S., Little, S.R., & Clemens, P.R. (2012). Effect of rapamycin on immunity induced by vector-mediated dystrophin expression in mdx skeletal muscle. SCIENTIFIC REPORTS, 2(1), 399.Springer Science and Business Media LLC. doi: 10.1038/srep00399.

Jhunjhunwala, S., Balmert, S.C., Raimondi, G., Dons, E., Nichols, E.E., Thomson, A.W., & Little, S.R. (2012). Controlled release formulations of IL-2, TGF-beta 1 and rapamycin for the induction of regulatory T cells. JOURNAL OF CONTROLLED RELEASE, 159(1), 78-84.Elsevier BV. doi: 10.1016/j.jconrel.2012.01.013.

Jhunjhunwala, S., Raimondi, G., Glowacki, A.J., Hall, S.J., Maskarinec, D., Thorne, S.H., Thomson, A.W., & Little, S.R. (2012). Bioinspired Controlled Release of CCL22 Recruits Regulatory T Cells In Vivo. ADVANCED MATERIALS, 24(35), 4735-4738.Wiley. doi: 10.1002/adma.201202513.

Li, J., Rothstein, S.N., Little, S.R., Edenborn, H.M., & Meyer, T.Y. (2012). The Effect of Monomer Order on the Hydrolysis of Biodegradable Poly(lactic-co-glycolic acid) Repeating Sequence Copolymers. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(39), 16352-16359.American Chemical Society (ACS). doi: 10.1021/ja306866w.

Little, S. (2012). The importance of peer-review. Gen Dent, 60(4), 251.

Little, S.R. (2012). Reorienting our view of particle-based adjuvants for subunit vaccines. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(4), 999-1000.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1120993109.

Rothstein, S.N., Kay, J.E., Schopfer, F.J., Freeman, B.A., & Little, S.R. (2012). A Retrospective Mathematical Analysis of Controlled Release Design and Experimentation. MOLECULAR PHARMACEUTICS, 9(11), 3003-3011.American Chemical Society (ACS). doi: 10.1021/mp300388w.

Tengood, J.E., Maskarinec, D., Ridenour, R., & Little, S.R. (2012). A mathematical model for release of biologics from porous hollow fibers. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 100A(4), 817-826.Wiley. doi: 10.1002/jbm.a.34013.

Dutt, M., Kuksenok, O., Little, S.R., & Balazs, A.C. (2011). Forming transmembrane channels using end-functionalized nanotubes. NANOSCALE, 3(1), 240-250.Royal Society of Chemistry (RSC). doi: 10.1039/c0nr00578a.

Dutt, M., Kuksenok, O., Nayhouse, M.J., Little, S.R., & Balazs, A.C. (2011). Modeling the Self-Assembly of Lipids and Nanotubes in Solution: Forming Vesicles and Bicelles with Transmembrane Nanotube Channels. ACS NANO, 5(6), 4769-4782.American Chemical Society (ACS). doi: 10.1021/nn201260r.

Dutt, M., Nayhouse, M.J., Kuksenok, O., Little, S.R., & Balazs, A.C. (2011). Interactions of End-functionalized Nanotubes with Lipid Vesicles: Spontaneous Insertion and Nanotube Self-Organization. CURRENT NANOSCIENCE, 7(5), 699-715.Bentham Science Publishers Ltd. doi: 10.2174/157341311797483772.

Eghtesad, S., Jhunjhunwala, S., Little, S.R., & Clemens, P.R. (2011). Rapamycin Ameliorates Dystrophic Phenotype in mdx Mouse Skeletal Muscle. MOLECULAR MEDICINE, 17(9-10), 917-924.Springer Science and Business Media LLC. doi: 10.2119/molmed.2010.00256.

Jhunjhunwala, S., & Little, S.R. (2011). Microparticulate systems for targeted drug delivery to phagocytes. CELL CYCLE, 10(13), 2047-2048.Informa UK Limited. doi: 10.4161/cc.10.13.15713.

Kamalasanan, K., Jhunjhunwala, S., Wu, J., Swanson, A., Gao, D., & Little, S.R. (2011). Patchy, Anisotropic Microspheres with Soft Protein Islets. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(37), 8706-8708.Wiley. doi: 10.1002/anie.201101217.

Rothstein, S.N., & Little, S.R. (2011). A "tool box" for rational design of degradable controlled release formulations. JOURNAL OF MATERIALS CHEMISTRY, 21(1), 29-39.Royal Society of Chemistry (RSC). doi: 10.1039/c0jm01668c.

Tengood, J.E., Ridenour, R., Brodsky, R., Russell, A.J., & Little, S.R. (2011). Sequential Delivery of Basic Fibroblast Growth Factor and Platelet-Derived Growth Factor for Angiogenesis. TISSUE ENGINEERING PART A, 17(9-10), 1181-1189.Mary Ann Liebert Inc. doi: 10.1089/ten.tea.2010.0551.

Alberto Fierro, J., Ramirez, V., Silva, C., Ruiz, P., Gleisner, A., Morales, J., Jhunjhunwala, S., Little, S.R., Rosa Bono, M., & Rosemblatt, M. (2010). Transference of Phagosomes in an Allogeneic Immunisation Protocol Down Regulates the Production of Anti-MHC Antibodies and T Cell Mediated Alloreactivity. AMERICAN JOURNAL OF TRANSPLANTATION, 10(14), 562.

Brito, L.A., Chandrasekhar, S., Little, S.R., & Amiji, M.M. (2010). Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis. BIOMEDICAL ENGINEERING ONLINE, 9(1), 56.Springer Science and Business Media LLC. doi: 10.1186/1475-925X-9-56.

Brito, L.A., Chandrasekhar, S., Little, S.R., & Amiji, M.M. (2010). In vitro and in vivo studies of local arterial gene delivery and transfection using lipopolyplexes-embedded stents. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 93A(1), 325-336.Wiley. doi: 10.1002/jbm.a.32488.

Kokai, L.E., Tan, H., Jhunjhunwala, S., Little, S.R., Frank, J.W., & Marra, K.G. (2010). Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres. JOURNAL OF CONTROLLED RELEASE, 141(2), 168-176.Elsevier BV. doi: 10.1016/j.jconrel.2009.09.003.

Tengood, J.E., Kovach, K.M., Vescovi, P.E., Russell, A.J., & Little, S.R. (2010). Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. BIOMATERIALS, 31(30), 7805-7812.Elsevier BV. doi: 10.1016/j.biomaterials.2010.07.010.

van Vlerken, L.E., Duan, Z., Little, S.R., Seiden, M.V., & Amiji, M.M. (2010). Augmentation of Therapeutic Efficacy in Drug-Resistant Tumor Models Using Ceramide Coadministration in Temporal-Controlled Polymer-Blend Nanoparticle Delivery Systems. AAPS JOURNAL, 12(2), 171-180.Springer Science and Business Media LLC. doi: 10.1208/s12248-010-9174-4.

Rothstein, S.N., Federspiel, W.J., & Little, S.R. (2009). A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices. BIOMATERIALS, 30(8), 1657-1664.Elsevier BV. doi: 10.1016/j.biomaterials.2008.12.002.

Yadav, S., van Vlerken, L.E., Little, S.R., & Amiji, M.M. (2009). Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 63(4), 711-722.Springer Science and Business Media LLC. doi: 10.1007/s00280-008-0790-y.

Brito, L., Little, S., Langer, R., & Amiji, M. (2008). Poly(beta-amino ester) and cationic phospholipid-based lipopolyplexes for gene delivery and transfection in human aortic endothelial and smooth muscle cells. BIOMACROMOLECULES, 9(4), 1179-1187.American Chemical Society (ACS). doi: 10.1021/bm7011373.

Jhunjhunwala, S., Raimondi, G., Thomson, A.W., & Little, S.R. (2008). Delivery of rapamycin to dendritic cells using degradable microparticles. FASEB JOURNAL, 22(3), 191-197.Elsevier BV. doi: 10.1016/j.jconrel.2008.10.011.

Little, S.R., & Kohane, D.S. (2008). Polymers for intracellular delivery of nucleic acids. JOURNAL OF MATERIALS CHEMISTRY, 18(8), 832-841.Royal Society of Chemistry (RSC). doi: 10.1039/b712930k.

Raimondi, G., Jhunjhunwala, S., Thomson, A.W., & Little, S.R. (2008). Targeted delivery of rapamycin to dendritic cells using biodegradable microparticles is highly effective in suppressing their maturation and function. AMERICAN JOURNAL OF TRANSPLANTATION, 8(423), 423.

Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the rational design of controlled release therapeutics. AIChE Annual Meeting, Conference Proceedings.Carnegie Mellon University, Pittsburgh, Pennsylvania.

Rothstein, S.N., Federspiel, W.J., & Little, S.R. (2008). A simple model framework for the prediction of controlled release from bulk eroding polymer matrices. JOURNAL OF MATERIALS CHEMISTRY, 18(16), 1873-1880.Royal Society of Chemistry (RSC). doi: 10.1039/b718277e.

van Vlerken, L.E., Duan, Z., Little, S.R., Seiden, M.V., & Amiji, M.M. (2008). Biodistribution and pharmacokinetic analysis of paclitaxel and ceramide administered in multifunctional polymer-blend nanoparticles in drug resistant breast cancer model. MOLECULAR PHARMACEUTICS, 5(4), 516-526.American Chemical Society (ACS). doi: 10.1021/mp800030k.

Choleris, E., Little, S.R., Mong, J.A., Puram, S.V., Langer, R., & Pfaff, D.W. (2007). Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(11), 4670-4675.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0700670104.

Devalapally, H., Shenoy, D., Little, S., Langer, R., & Amiji, M. (2007). Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 59(4), 477-484.Springer Science and Business Media LLC. doi: 10.1007/s00280-006-0287-5.

Zugates, G.T., Anderson, D.G., Little, S.R., Lawhorn, I.E.B., & Langer, R. (2006). Synthesis of poly(beta-amino ester)s with thiol-reactive side chains for DNA delivery. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(39), 12726-12734.American Chemical Society (ACS). doi: 10.1021/ja061570n.

Little, S.R., & Langer, R. (2005). Nonviral delivery of cancer genetic vaccines. GENE THERAPY AND GENE DELIVERY SYSTEMS, 99, 93-118.Springer-Verlag. doi: 10.1007/10_004.

Little, S.R., Lynn, D.M., Puram, S.V., & Langer, R. (2005). Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery. JOURNAL OF CONTROLLED RELEASE, 107(3), 449-462.Elsevier BV. doi: 10.1016/j.jconrel.2005.04.022.

Pfeifer, B.A., Burdick, J.A., Little, S.R., & Langer, R. (2005). Poly(ester-anhydride): poly(beta-amino ester) micro- and nanospheres: DNA encapsulation and cellular transfection. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 304(1-2), 210-219.Elsevier BV. doi: 10.1016/j.ijpharm.2005.08.001.

Shenoy, D., Little, S., Langer, R., & Amiji, M. (2005). Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: Part 2. In vivo distribution and tumor localization studies. PHARMACEUTICAL RESEARCH, 22(12), 2107-2114.Springer Science and Business Media LLC. doi: 10.1007/s11095-005-8343-0.

Shenoy, D., Little, S., Langer, R., & Amiji, M. (2005). Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations. MOLECULAR PHARMACEUTICS, 2(5), 357-366.American Chemical Society (ACS). doi: 10.1021/mp0500420.

Wood, K.C., Little, S.R., Langer, R., & Hammond, P.T. (2005). A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 44(41), 6704-6708.Wiley. doi: 10.1002/anie.200502152.

Zugates, G.T., Little, S.R., Anderson, D.G., & Langer, R. (2005). Poly(beta-amino ester)s for DNA delivery. ISRAEL JOURNAL OF CHEMISTRY, 45(4), 477-485.Wiley. doi: 10.1560/7C67-5X19-PEJ8-PXUN.

Haining, W.N., Anderson, D.G., Little, S.R., Cardoso, A.A., Alves, P., Kosmatopoulos, K., Nadler, L.M., Langer, R., Kohane, D.S., & Von Bergwelt-Baildon, M.S. (2004). Erratum: pH-triggered microparticles for peptide vaccination (Journal of Immunology (2004) 173 (2578-2585)). Journal of Immunology, 173(10), 6490.

Haining, W.N., Anderson, D.G., Little, S.R., von Berwelt-Baildon, M.S., Cardoso, A.A., Alves, P., Kosmatopoulos, K., Nadler, L.M., Langer, R., & Kohane, D.S. (2004). pH-triggered microparticles for peptide vaccination. JOURNAL OF IMMUNOLOGY, 173(4), 2578-2585.The American Association of Immunologists. doi: 10.4049/jimmunol.173.4.2578.

Little, S.R., Lynn, D.M., Ge, Q., Anderson, D.G., Puram, S.V., Chen, J., Eisen, H.N., & Langer, R. (2004). Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci U S A, 101(26), 9534-9539.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0403549101.

Little, S.R., Lynn, D.M., Ge, Q., Anderson, D.G., Puram, S.V., Chen, J.Z., Eisen, H.N., & Langer, R. (2004). Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(26), 9534-9539. doi: 10.1073/pnas.0403549101.

Balmert, S.C., Carey, C.D., Erdos, G., Korkmaz, E., Little, S.R., & Falo, L.D. (2020). Engineering the skin with microneedle arrays to induce immune tolerance. In JOURNAL OF INVESTIGATIVE DERMATOLOGY, 140(7), (p. S11).

Fisher, J.D., Zhang, W., Balmert, S.C., Aral, A.M., Kulahci, Y., Acharya, A.P., Li, J., Turnquist, H.R., Thomson, A.W., Solari, M.G., Gorantla, V.S., & Little, S.R. (2020). Recruitment of Regulatory T Cells Promotes Donor-Specific Tolerance in Vascularized Composite Allotransplantation. In AMERICAN JOURNAL OF TRANSPLANTATION, 20, (p. 536).

Balmert, S.C., Carey, C.D., Erdos, G., Little, S.R., & Falo, L.D. (2019). Microneedle arrays engineer the skin microenvironment to promote allergen tolerance. In JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(5), (p. S11).

Fedorchak, M.V., Kowalski, R.P., Romanowski, E.G., Schuman, J.S., & Little, S.R. (2016). Development of a semi-permanent, controlled release antibiotic eye drop. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12).

Biguetti, C.C., Vieira, A.E., Colavite, P., Cavalla, F., Francisconi, C., Trombone, A.F., Sfeir, C., Little, S.R., & Garlet, G.P. (2015). Impact of CCR2-Mediated Immunomodulation in the Outcome Bone Repair Process. In TISSUE ENGINEERING PART A, 21, (pp. S42-S43).

Gottardi, R., Bianconi, P.A., Manner, P.A., Alexander, P.G., Little, S.R., & Tuan, R.S. (2015). Prevention of Cartilage Calcification by Controlled Release of Dorsomorphin. Penn Orthopedics Cartilage Repair Symposium.Philadelphia, PA.

Bodnar, C.A., Beckman, E.J., McCarthy, J.J., & Little, S.R. (2014). A vision for the first product innovation sequence for chemical engineers. In ASEE Annual Conference and Exposition, Conference Proceedings.

Li, J., & Meyer, T.Y. (2013). Engineering hydrolysis behavior of poly(lactic-co-glycolic acid) through precise control of monomer sequence. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 246, (pp. 271-286).American Chemical Society. doi: 10.1021/bk-2014-1170.ch018.

Little, S.R., Glowacki, A., Jhunjhunwala, S., Yoshizawa, S., Garlet, G.P., & Sfeir, C. (2012). Rationally designed controlled release systems for periodontal disease that promote immunological homeostasis. Symposium on Polymers at the Interface of Biology.Philadelphia, PA.

Raimondi, G., Jhunjhunwala, S., Nichols, E., Thomson, A., & Little, S. (2012). All-trans retinoic acid and rapamycin synergize with transforming growth factor-B to induce regulatory T cells but confer distinct in vivo migratory capacities. Joint Annual Meeting of the International Cytokines Society and International Society for Interferon and Cytokine Research.Geneva, Switzerland. doi: 10.1016/j.cyto.2012.06.259.

Raimondi, G., Jhunjhunwala, S., Grahammer, J., Qi, M., Hall, S., Thorne, S.H., Thomson, A.W., Brandacher, G., & Little, S.R. (2011). Biomimetic Controlled Release of CCL22 for In Vivo Recruitment of Regulatory T Cells and Prolongation of Allograft Survival. American Transplant Congress.Philadelphia, PA.

Jhunjhunwala, S., Raimondi, G., Hall, S., Thorne, S., Thomson, A., & Little, S. (2010). Bio-inspired controlled release for regulatory T cell recruitment in vivo. The American Association of Immunologist, Immunology 2010.Baltimore, MD.

Jhunjhunwala, S., Raimondi, G., Thomson, A.W., & Little, S.R. (2009). Delivery of rapamycin to dendritic cells using degradable microparticles. Experimental Biology 2008.San Diego, CA. doi: 10.1016/j.jconrel.2008.10.011.

Little, S. (2009). Polymeric microcapsulates as a platform technology for biomimetic drug delivery. Duquesne University.Pittsburgh, PA.

Brito, L., Chandrasekhar, S., Little, S., & Amiji, M. (2008). Gene delivery and transfection studies with lipopolyplexes in human endothelial and smooth muscle cells. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, 2, (pp. 365-368).

Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Controlled Release Therapeutics. AIChE 2008 Annual Meeting.Philadelphia, PA.

Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Biodegradable Controlled Release Vehicles. AIChE 2008 Annual Meeting.Philadelphia, PA.

Rothstein, S.N., Federspiel, W., & Little, S. (2008). A unified mathematical model for predicting controlled release from surface and bulk eroding matrices without regression. Poster session presented at the meeting of AIChE 2008 Annual Meeting.Philadelphia, PA.

Rothstein, S.N., Federspiel, W., & Little, S. (2008). Towards the Rational Design of Controlled Release Therapeutics. Biotechnology and Bioengineering Research Symposium. Biomedical Engineering Graduate Society Symposium, Carnegie Mellon University.Pittsburgh, PA.

Tengood, J., Wagner, W., Gerlach, J., Russell, A., & Little, S.R. (2008). Dissolvable hollow fibers for delivery in wound healing. In 8th World Biomaterials Congress 2008, 1, (p. 310).

Research interests

biomaterials
controlled release
delivery of drugs to the eye
drug delivery systems
immunotherapies
Regenerative Medicine