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Cockrell, C., Vodovotz, Y., Zamora, R., & An, G. (2024). The Wound Environment Agent-based Model (WEABM): a digital twin platform for characterization and complex therapeutic discovery for volumetric muscle loss. bioRxiv, 2024.06.04.595972.Cold Spring Harbor Laboratory. doi: 10.1101/2024.06.04.595972.
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Prabahar, A., Zamora, R., Barclay, D., Yin, J., Ramamoorthy, M., Bagheri, A., Johnson, S.A., Badylak, S., Vodovotz, Y., & Jiang, P. (2024). Unraveling the complex relationship between mRNA and protein abundances: a machine learning-based approach for imputing protein levels from RNA-seq data. NAR Genom Bioinform, 6(1), lqae019.Oxford University Press (OUP). doi: 10.1093/nargab/lqae019.
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Shah, A.M., Aral, A.M., Barclay, D.A., Yin, J., Zamora, R., Gorantla, V., & Vodovotz, Y. (2024). Implications of an Altered Gut Microbiome in Rat Experimental Vascularized Composite Transplantation. Exp Clin Transplant, 22(2), 137-147.Baskent University. doi: 10.6002/ect.2023.0312.
Shah, A.M., Zamora, R., Barclay, D., Yin, J., El-Dehaibi, F., Addorisio, M., Tsaava, T., Tynan, A., Tracey, K., Chavan, S.S., & Vodovotz, Y. (2024). Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation. Front Syst Biol, 4, 1266279.Frontiers. doi: 10.3389/fsysb.2024.1266279.
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Vodovotz, Y., Arciero, J., Verschure, P.F., & Katz, D.L. (2024). A multiscale inflammatory map: linking individual stress to societal dysfunction. Front Sci, 1, 1239462.Frontiers. doi: 10.3389/fsci.2023.1239462.
Zamora, R., Barclay, D.A., Yin, J., El-Dehaibi, F., Johnson, S.A., An, G., Badylak, S.F., & Vodovotz, Y. (2024). Data‐driven modeling of local and systemic inflamma on in a canine model of volumetric muscle loss injury. Journal of Critical Care, 81, 154557.Elsevier. doi: 10.1016/j.jcrc.2024.154557.
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El-Dehaibi, F., Zamora, R., Radder, J., Yin, J., Shah, A.M., Namas, R.A., Situ, M., Zhao, Y., Bain, W., Morris, A., McVerry, B.J., Barclay, D.A., Billiar, T.R., Zhang, Y., Kitsios, G.D., & Vodovotz, Y. (2023). A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes. iScience, 26(12), 108333.Elsevier. doi: 10.1016/j.isci.2023.108333.
Jhamb, M., Steel, J.L., Yabes, J.G., Roumelioti, M.E., Erickson, S., Devaraj, S.M., Vowles, K.E., Vodovotz, Y., Beach, S., Weisbord, S.D., Rollman, B.L., & Unruh, M. (2023). Effects of Technology Assisted Stepped Collaborative Care Intervention to Improve Symptoms in Patients Undergoing Hemodialysis: The TĀCcare Randomized Clinical Trial. JAMA Intern Med, 183(8), 795-805.American Medical Association (AMA). doi: 10.1001/jamainternmed.2023.2215.
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Reitz, K.M., Althouse, A.D., Forman, D.E., Zuckerbraun, B.S., Vodovotz, Y., Zamora, R., Raffai, R.L., Hall, D.E., & Tzeng, E. (2023). MetfOrmin BenefIts Lower Extremities with Intermittent Claudication (MOBILE IC): randomized clinical trial protocol. BMC Cardiovasc Disord, 23(1), 38.Springer Nature. doi: 10.1186/s12872-023-03047-8.
Seymour, C.W., Urbanek, K.L., Nakayama, A., Kennedy, J.N., Powell, R., Robinson, R.A.S., Kapp, K.L., Billiar, T.R., Vodovotz, Y., Gelhaus, S.L., Cooper, V.S., Tang, L., Mayr, F., Reitz, K.M., Horvat, C., Meyer, N.J., Dickson, R.P., Angus, D., & Palmer, O.P. (2023). A Prospective Cohort Protocol for the Remnant Investigation in Sepsis Study. Crit Care Explor, 5(11), e0974.Wolters Kluwer. doi: 10.1097/CCE.0000000000000974.
Shah, A., Zamora, R., Forsberg, J., Schobel, S., Unselt, D., Grey, S., Billiar, T.R., Elster, E., & Vodovotz, Y. (2023). Dynamic Hypergraphs: A novel analysis pipeline for defining spatiotemporal inflammation networks. Journal of Critical Care, 74, 154199.Elsevier. doi: 10.1016/j.jcrc.2022.154199.
Shah, A.M., Aral, A.M., Zamora, R., Gharpure, N., El-Dehaibi, F., Zor, F., Kulahci, Y., Karagoz, H., Barclay, D.A., Yin, J., Breidenbach, W., Tuder, D., Gorantla, V.S., & Vodovotz, Y. (2023). Peripheral nerve repair is associated with augmented cross-tissue inflammation following vascularized composite allotransplantation. Front Immunol, 14, 1151824.Frontiers. doi: 10.3389/fimmu.2023.1151824.
Shah, A.M., Vodovotz, Y., Yoshimura, N., Chermansky, C.J., Fitzgerald, J., & Tyagi, P. (2023). Temporally complex inflammatory networks in an animal model reveal signatures for interstitial cystitis and bladder pain syndrome phenotype. Neurourol Urodyn, 42(8), 1839-1848.Wiley. doi: 10.1002/nau.25267.
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Shah, K., Geller, D.A., Tohme, S., Antoni, M., Kallem, C.J., Vodovotz, Y., Ramanathan, R., Naveen, R., Geroni, M., Devine, L., Amin, A., Kiefer, G.J., Zandberg, D.P., Reyes, V., & Steel, J.L. (2023). Predictors and Consequences of Cancer and Non-Cancer-Related Pain in Those Diagnosed with Primary and Metastatic Cancers. Curr Oncol, 30(10), 8826-8840.MDPI. doi: 10.3390/curroncol30100637.
Singh-Varma, A., Shah, A.M., Liu, S., Zamora, R., Monga, S.P., & Vodovotz, Y. (2023). Defining spatiotemporal gene modules in liver regeneration using Analytical Dynamic Visual Spatial Omics Representation (ADViSOR). Hepatol Commun, 7(11).Wolters Kluwer. doi: 10.1097/HC9.0000000000000289.
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Zamora, R., Forsberg, J.A., Shah, A.M., Unselt, D., Grey, S., Lisboa, F.A., Billiar, T.R., Schobel, S.A., Potter, B.K., Elster, E.A., & Vodovotz, Y. (2023). Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties. Sci Rep, 13(1), 6618.Springer Nature. doi: 10.1038/s41598-023-33623-z.
Abdelhamid, S.S., Scioscia, J., Vodovotz, Y., Wu, J., Rosengart, A., Sung, E., Rahman, S., Voinchet, R., Bonaroti, J., Li, S., Darby, J.L., Kar, U.K., Neal, M.D., Sperry, J., Das, J., & Billiar, T.R. (2022). Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients. Metabolites, 12(9).MDPI. doi: 10.3390/metabo12090774.
Bonaroti, J., Billiar, I., Moheimani, H., Wu, J., Namas, R., Li, S., Kar, U.K., Vodovotz, Y., Neal, M.D., Sperry, J.L., & Billiar, T.R. (2022). Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill. Front Immunol, 13, 1038086.Frontiers. doi: 10.3389/fimmu.2022.1038086.
Chen, T., Conroy, J., Wang, X., Situ, M., Namas, R.A., Vodovotz, Y., Chen, W., Singh, H., & Billiar, T.R. (2022). The independent prognostic value of global epigenetic alterations: An analysis of single-cell ATAC-seq of circulating leukocytes from trauma patients followed by validation in whole blood leukocyte transcriptomes across three etiologies of critical illness. EBioMedicine, 76, 103860.Elsevier. doi: 10.1016/j.ebiom.2022.103860.
Chen, T., Wei, Y., Vodovotz, Y., Chen, W., & Billiar, T.R. (2022). LONGITUDINAL ANALYSIS OF TRANSCRIPTOMIC SUBTYPES IN TRAUMA PATIENTS. Shock, 58(1), 34-37.Wolters Kluwer. doi: 10.1097/SHK.0000000000001958.
Cockrell, C., Schobel-McHugh, S., Lisboa, F., Vodovotz, Y., & An, G. (2022). Generating synthetic data with a mechanism-based Critical Illness Digital Twin: Demonstration for Post Traumatic Acute Respiratory Distress Syndrome. In bioRxiv. doi: 10.1101/2022.11.22.517524.
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Schumaker, G., Becker, A., An, G., Badylak, S., Johnson, S., Jiang, P., Vodovotz, Y., & Cockrell, R.C. (2022). Optical Biopsy Using a Neural Network to Predict Gene Expression From Photos of Wounds. J Surg Res, 270, 547-554.Elsevier. doi: 10.1016/j.jss.2021.10.017.
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Shah, A.M., Zamora, R., Korff, S., Barclay, D., Yin, J., El-Dehaibi, F., Billiar, T.R., & Vodovotz, Y. (2022). Inferring Tissue-Specific, TLR4-Dependent Type 17 Immune Interactions in Experimental Trauma/Hemorrhagic Shock and Resuscitation Using Computational Modeling. Front Immunol, 13, 908618.Frontiers. doi: 10.3389/fimmu.2022.908618.
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Wu, J., Cyr, A., Gruen, D.S., Lovelace, T.C., Benos, P.V., Das, J., Kar, U.K., Chen, T., Guyette, F.X., Yazer, M.H., Daley, B.J., Miller, R.S., Harbrecht, B.G., Claridge, J.A., Phelan, H.A., Zuckerbraun, B.S., Neal, M.D., Johansson, P.I., Stensballe, J., Namas, R.A., Vodovotz, Y., Sperry, J.L., Billiar, T.R., & PAMPer study group. (2022). Lipidomic signatures align with inflammatory patterns and outcomes in critical illness. Nat Commun, 13(1), 6789.Springer Nature. doi: 10.1038/s41467-022-34420-4.
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An, G., Cockrell, C., Zamora, R., & Vodovotz, Y. (2021). 11 Machine learning and mechanistic computational modeling of inflammation as tools for designing immunomodulatory biomaterials. In Immunomodulatory Biomaterials. (pp. 251-272).Elsevier. doi: 10.1016/b978-0-12-821440-4.00009-8.
Aral, A.M., Zamora, R., Barclay, D., Yin, J., El-Dehaibi, F., Erbas, V.E., Dong, L., Zhang, Z., Sahin, H., Gorantla, V.S., & Vodovotz, Y. (2021). The Effects of Tacrolimus on Tissue-Specific, Protein-Level Inflammatory Networks in Vascularized Composite Allotransplantation. Front Immunol, 12, 591154.Frontiers. doi: 10.3389/fimmu.2021.591154.
Azhar, N., Namas, R.A., Almahmoud, K., Zaaqoq, A., Malak, O.A., Barclay, D., Yin, J., El-Dehaibi, F., Abboud, A., Simmons, R.L., Zamora, R., Billiar, T.R., & Vodovotz, Y. (2021). A putative "chemokine switch" that regulates systemic acute inflammation in humans. Sci Rep, 11(1), 9703.Springer Nature. doi: 10.1038/s41598-021-88936-8.
Barber, J., Carpenter, A., Torsey, A., Borgard, T., Namas, R.A., Vodovotz, Y., & Arciero, J. (2021). Predicting Experimental Sepsis Survival with a Mathematical Model of Acute Inflammation. FRONTIERS IN SYSTEMS BIOLOGY, 1.Frontiers. doi: 10.3389/fsysb.2021.755913.
Bonaroti, J., Abdelhamid, S., Kar, U., Sperry, J., Zamora, R., Namas, R.A., McKinley, T., Vodovotz, Y., & Billiar, T. (2021). The Use of Multiplexing to Identify Cytokine and Chemokine Networks in the Immune-Inflammatory Response to Trauma. Antioxid Redox Signal, 35(16), 1393-1406.SAGE Publications. doi: 10.1089/ars.2021.0054.
Cai, J., McKinley, T., Billiar, I., Zenati, M.S., Gaski, G., Vodovotz, Y., Gruen, D.S., Billiar, T.R., & Namas, R.A. (2021). Protective/reparative cytokines are suppressed at high injury severity in human trauma. Trauma Surg Acute Care Open, 6(1), e000619.BMJ. doi: 10.1136/tsaco-2020-000619.
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Chen, T., Delano, M.J., Chen, K., Sperry, J.L., Namas, R.A., Lamparello, A.J., Deng, M., Conroy, J., Moldawer, L.L., Efron, P.A., Loughran, P., Seymour, C., Angus, D.C., Vodovotz, Y., Chen, W., & Billiar, T.R. (2021). A road map from single-cell transcriptome to patient classification for the immune response to trauma. JCI Insight, 6(2).American Society for Clinical Investigation. doi: 10.1172/jci.insight.145108.
Chopra, A., Zamora, R., Vodovotz, Y., Hodges, J.C., Barclay, D., Brand, R., Simmons, R.L., Lee, K.K., Paniccia, A., Murthy, P., Lotze, M.T., Boone, B.A., & Zureikat, A.H. (2021). Baseline Plasma Inflammatory Profile Is Associated With Response to Neoadjuvant Chemotherapy in Patients With Pancreatic Adenocarcinoma. J Immunother, 44(5), 185-192.Wolters Kluwer. doi: 10.1097/CJI.0000000000000370.
Cyr, A., Zhong, Y., Reis, S.E., Namas, R.A., Amoscato, A., Zuckerbraun, B., Sperry, J., Zamora, R., Vodovotz, Y., & Billiar, T.R. (2021). Analysis of the Plasma Metabolome after Trauma, Novel Circulating Sphingolipid Signatures, and In-Hospital Outcomes. J Am Coll Surg, 232(3), 276-287.e1.Wolters Kluwer. doi: 10.1016/j.jamcollsurg.2020.12.022.
Day, J.D., Park, S., Ranard, B.L., Singh, H., Chow, C.C., & Vodovotz, Y. (2021). Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model. Front Immunol, 12, 754127.Frontiers. doi: 10.3389/fimmu.2021.754127.
Heipertz, E.L., Harper, J., Goswami, D.G., Lopez, C.A., Nellikappallil, J., Zamora, R., Vodovotz, Y., & Walker, W.E. (2021). IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis. J Immunol, 206(2), 398-409.Oxford University Press (OUP). doi: 10.4049/jimmunol.1900217.
Larie, D., An, G., Johnson, S., Hoffman, K., Vodovotz, Y., Badylak, S., & Cockrell, C. (2021). Quantifying the size and healing of volumetric muscle wounds using 3D Slicer on CT scans in a canine model. In bioRxiv. doi: 10.1101/2021.07.13.452185.
Lin, M., Huang, W., Kabbani, N., Theiss, M.M., Hamilton, J.F., Ecklund, J.M., Conley, Y.P., Vodovotz, Y., Brienza, D., Wagner, A.K., Robbins, E., Sowa, G.A., & Lipsky, R.H. (2021). Effect of CHRFAM7A Δ2bp gene variant on secondary inflammation after spinal cord injury. In Hetman, M. (Ed.). PLoS One, 16(5), e0251110.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0251110.
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Abboud, A., Mi, Q., Puccio, A., Okonkwo, D., Buliga, M., Constantine, G., & Vodovotz, Y. (2016). Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death. Front Pharmacol, 7(SEP), 342.Frontiers. doi: 10.3389/fphar.2016.00342.
Abboud, A., Namas, R.A., Ramadan, M., Mi, Q., Almahmoud, K., Abdul-Malak, O., Azhar, N., Zaaqoq, A., Namas, R., Barclay, D.A., Yin, J., Sperry, J., Peitzman, A., Zamora, R., Simmons, R.L., Billiar, T.R., & Vodovotz, Y. (2016). Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality. Crit Care Med, 44(11), e1074-e1081.Wolters Kluwer. doi: 10.1097/CCM.0000000000001951.
Abdul-Malak, O., Vodovotz, Y., Zaaqoq, A., Guardado, J., Almahmoud, K., Yin, J., Zuckerbraun, B., Peitzman, A.B., Sperry, J., Billiar, T.R., & Namas, R.A. (2016). Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients. Mediators Inflamm, 2016(1), 7950374.Hindawi. doi: 10.1155/2016/7950374.
Buchman, T.G., Billiar, T.R., Elster, E., Kirk, A.D., Rimawi, R.H., Vodovotz, Y., & Zehnbauer, B.A. (2016). Precision Medicine for Critical Illness and Injury. Crit Care Med, 44(9), 1635-1638.Wolters Kluwer. doi: 10.1097/CCM.0000000000002028.
Constantine, G., Buliga, M., Mi, Q., Constantine, F., Abboud, A., Zamora, R., Puccio, A., Okonkwo, D., & Vodovotz, Y. (2016). Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients. Front Pharmacol, 7(NOV), 383.Frontiers. doi: 10.3389/fphar.2016.00383.
Kassab, G.S., An, G., Sander, E.A., Miga, M.I., Guccione, J.M., Ji, S., & Vodovotz, Y. (2016). Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective. Ann Biomed Eng, 44(9), 2611-2625.Springer Nature. doi: 10.1007/s10439-016-1596-4.
Krishnan, S., Karg, P.E., Boninger, M.L., Vodovotz, Y., Constantine, G., Sowa, G.A., & Brienza, D.M. (2016). Early Detection of Pressure Ulcer Development Following Traumatic Spinal Cord Injury Using Inflammatory Mediators. Arch Phys Med Rehabil, 97(10), 1656-1662.Elsevier. doi: 10.1016/j.apmr.2016.01.003.
Krishnan, S., Vodovotz, Y., Karg, P.E., Constantine, G., Sowa, G.A., & Brienza, D.M. (2016). Biomarkers Associated with Pressure Ulcer Formation in Traumatic Spinal Cord Individuals with Pneumonia. Archives of Physical Medicine and Rehabilitation, 97(10), e128-e129.Elsevier. doi: 10.1016/j.apmr.2016.08.401.
Liu, D., Namas, R., Mi, Q., Abdul-Malak, O., Guardado, J., Zuckerbraun, B., Sperry, J., Rosengart, M., Vodovotz, Y., & Billiar, T. (2016). QUANTIFICATION OF CUMULATIVE MULTIPLE ORGAN DYSFUNCTION SCORES IDENTIFIES PHENOTYPIC CLUSTERS AND BIOMARKER PATTERNS IN BLUNT TRAUMA PATIENTS. SHOCK, 45(6), 48.
Namas, R.A., & Vodovotz, Y. (2016). From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients. Ann Transl Med, 4(24), 492.AME Publishing Company. doi: 10.21037/atm.2016.11.72.
Namas, R.A., Almahmoud, K., Mi, Q., Ghuma, A., Namas, R., Zaaqoq, A., Zhu, X., Abdul-Malak, O., Sperry, J., Zamora, R., Billiar, T.R., & Vodovotz, Y. (2016). Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients. J Crit Care, 36, 146-153.Elsevier. doi: 10.1016/j.jcrc.2016.07.002.
Namas, R.A., Vodovotz, Y., Almahmoud, K., Abdul-Malak, O., Zaaqoq, A., Namas, R., Mi, Q., Barclay, D., Zuckerbraun, B., Peitzman, A.B., Sperry, J., & Billiar, T.R. (2016). Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans. Ann Surg, 263(1), 191-198.Wolters Kluwer. doi: 10.1097/SLA.0000000000001001.
Parker, R.S., Hogg, J.S., Roy, A., Kellum, J.A., Rimmelé, T., Daun-Gruhn, S., Fedorchak, M.V., Valenti, I.E., Federspiel, W.J., Rubin, J., Vodovotz, Y., Lagoa, C., & Clermont, G. (2016). Modeling and Hemofiltration Treatment of Acute Inflammation. Processes (Basel), 4(4), 38.MDPI. doi: 10.3390/pr4040038.
Roy, S., Sadowitz, B., Andrews, P., Gatto, L.A., Marx, W., Ge, L., Wang, G., Lin, X., Dean, D.A., Kuhn, M., Ghosh, A., Satalin, J., Snyder, K., Vodovotz, Y., Nieman, G., & Habashi, N. (2016). Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: A novel timing-based ventilatory intervention to avert lung injury (vol 73, pg 391, 2012). JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 81(2), 405.
Sadowsky, D., Zamora, R., Barclay, D., Yin, J., Fontes, P., & Vodovotz, Y. (2016). Machine Perfusion of Porcine Livers with Oxygen-Carrying Solution Results in Reprogramming of Dynamic Inflammation Networks. Front Pharmacol, 7(NOV), 413.Frontiers. doi: 10.3389/fphar.2016.00413.
Vodovotz, Y. (2016). Reverse Engineering the Inflammatory "Clock": From Computational Modeling to Rational Resetting. Drug Discov Today Dis Models, 22, 57-63.Elsevier. doi: 10.1016/j.ddmod.2017.03.001.
Abboud, A., Constantine, G., Puccio, A., Buliga, M., Solovyev, A., Mi, Q., Okonkwo, D., & Vodovotz, Y. (2015). DYNAMIC PROFILING: OUTCOME PREDICTION IN TBI BASED ON DEMOGRAPHICS, INJURY CHARACTERISTICS, AND INFLAMMATORY MEDIATORS. JOURNAL OF NEUROTRAUMA, 32(12), A104.
Abboud, A., Constantine, G., Puccio, A., Mi, Q., Okonkwo, D., & Vodovotz, Y. (2015). DIFFERENTIAL DYNAMIC NETWORKS OF INFLAMMATION IN CEREBROSPINAL FLUID OF TRAUMATIC BRAIN INJURY SEGREGATE SURVIVORS & NON-SURVIVORS. JOURNAL OF NEUROTRAUMA, 32(12), A104.
Abboud, A.N., Namas, R.A., Mi, Q., Almahmoud, K.W., Abdul-Malak, O.M., Barclay, D., Yin, J., Zamora, R., Billiar, T., & Vodovotz, Y. (2015). DYNAMIC INFLAMMATORY NETWORKS SUGGEST AN EARLY DIVERGENCE OF CLINICAL OUTCOMES IN BLUNT TRAUMA SURVIVORS VS. NON-SURVIVORS. SHOCK, 43(6), 97-98.
Almahmoud, K., Namas, R.A., Abdul-Malak, O., Zaaqoq, A.M., Zamora, R., Zuckerbraun, B.S., Sperry, J., Peitzman, A.B., Billiar, T.R., & Vodovotz, Y. (2015). Impact of Injury Severity on Dynamic Inflammation Networks Following Blunt Trauma. Shock, 44(2), 101-109.Wolters Kluwer. doi: 10.1097/SHK.0000000000000395.
Almahmoud, K., Namas, R.A., Zaaqoq, A.M., Abdul-Malak, O., Namas, R., Zamora, R., Sperry, J., Billiar, T.R., & Vodovotz, Y. (2015). Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans. Crit Care Med, 43(7), 1395-1404.Wolters Kluwer. doi: 10.1097/CCM.0000000000000964.
Brown, D., Namas, R.A., Almahmoud, K., Zaaqoq, A., Sarkar, J., Barclay, D.A., Yin, J., Ghuma, A., Abboud, A., Constantine, G., Nieman, G., Zamora, R., Chang, S.C., Billiar, T.R., & Vodovotz, Y. (2015). Trauma in silico: Individual-specific mathematical models and virtual clinical populations. Sci Transl Med, 7(285), 285ra61.American Association for the Advancement of Science (AAAS). doi: 10.1126/scitranslmed.aaa3636.
Buchholz, B.M., Shapiro, R.A., Vodovotz, Y., Billiar, T.R., Sodhi, C.P., Hackam, D.J., & Bauer, A.J. (2015). Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus. Am J Physiol Gastrointest Liver Physiol, 308(10), G852-G862.American Physiological Society. doi: 10.1152/ajpgi.00211.2014.
Day, J.D., Metes, D.M., & Vodovotz, Y. (2015). Mathematical Modeling of Early Cellular Innate and Adaptive Immune Responses to Ischemia/Reperfusion Injury and Solid Organ Allotransplantation. Front Immunol, 6(SEP), 484.Frontiers. doi: 10.3389/fimmu.2015.00484.
Fontes, P., Lopez, R., van der Plaats, A., Vodovotz, Y., Minervini, M., Scott, V., Soltys, K., Shiva, S., Paranjpe, S., Sadowsky, D., Barclay, D., Zamora, R., Stolz, D., Demetris, A., Michalopoulos, G., & Marsh, J.W. (2015). Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions. Am J Transplant, 15(2), 381-394.Elsevier. doi: 10.1111/ajt.12991.
Hussain, F., Langmead, C.J., Mi, Q., Dutta-Moscato, J., Vodovotz, Y., & Jha, S.K. (2015). Automated parameter estimation for biological models using Bayesian statistical model checking. BMC Bioinformatics, 16 Suppl 17(Suppl 17), S8.Springer Nature. doi: 10.1186/1471-2105-16-S17-S8.
Krishnan, S., Karg, P., Boninger, M., Vodovotz, Y., Constantine, G., Sowa, G., & Brienza, D.M. (2015). Early detection of pressure ulcer development following traumatic spinal cord injury using inflammatory mediator concentrations. Archives of Physical Medicine and Rehabilitation, 96(12), e22.Elsevier. doi: 10.1016/j.apmr.2015.10.059.
Namas, R.A., Mi, Q., Namas, R., Almahmoud, K., Zaaqoq, A.M., Abdul-Malak, O., Azhar, N., Day, J., Abboud, A., Zamora, R., Billiar, T.R., & Vodovotz, Y. (2015). Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation. Antioxid Redox Signal, 23(17), 1370-1387.SAGE Publications. doi: 10.1089/ars.2015.6398.
Nishikawa, T., Bell, A., Brooks, J.M., Setoyama, K., Melis, M., Han, B., Fukumitsu, K., Handa, K., Tian, J., Kaestner, K.H., Vodovotz, Y., Locker, J., Soto-Gutierrez, A., & Fox, I.J. (2015). Resetting the transcription factor network reverses terminal chronic hepatic failure. J Clin Invest, 125(4), 1533-1544.American Society for Clinical Investigation. doi: 10.1172/JCI73137.
Sadowsky, D., Nieman, G., Barclay, D., Mi, Q., Zamora, R., Constantine, G., Golub, L., Lee, H.M., Roy, S., Gatto, L.A., & Vodovotz, Y. (2015). Impact of chemically-modified tetracycline 3 on intertwined physiological, biochemical, and inflammatory networks in porcine sepsis/ARDS. Int J Burns Trauma, 5(1), 22-35.
Starzl, R., Wolfram, D., Zamora, R., Jefferson, B., Barclay, D., Ho, C., Gorantla, V., Brandacher, G., Schneeberger, S., Andrew Lee, W.P., Carbonell, J., & Vodovotz, Y. (2015). Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling. Front Immunol, 6(NOV), 587.Frontiers. doi: 10.3389/fimmu.2015.00587.
Vasudeva, K., Vodovotz, Y., Azhar, N., Barclay, D., Janjic, J.M., & Pollock, J.A. (2015). In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain. J Neuroimmunol, 283, 43-49.Elsevier. doi: 10.1016/j.jneuroim.2015.04.012.
Vodovotz, Y., & An, G. (2015). Translational Systems Biology. 1-162.Elsevier. doi: 10.1016/c2012-0-00091-9.
Vodovotz, Y., & An, G. (2015). Chapter 5.1 What Is Old Is New Again The Scientific Cycle in the Twenty-First Century and Beyond. In Translational Systems Biology. (pp. 149-157).Elsevier. doi: 10.1016/b978-0-12-397884-4.00016-1.
Vodovotz, Y., & An, G. (2015). Chapter 4.2 Data-Driven and Statistical Models Everything Old Is New Again. In Translational Systems Biology. (pp. 89-98).Elsevier. doi: 10.1016/b978-0-12-397884-4.00012-4.
Vodovotz, Y., & An, G. (2015). Chapter 4.4 Agent-Based Modeling and Translational Systems Biology An Evolution in Parallel. In Translational Systems Biology. (pp. 111-135).Elsevier. doi: 10.1016/b978-0-12-397884-4.00014-8.
Vodovotz, Y., & An, G. (2015). Chapter 4.5 Getting Science to Scale Accelerating the Development of Translational Computational Models. In Translational Systems Biology. (pp. 137-145).Elsevier. doi: 10.1016/b978-0-12-397884-4.00015-x.
Vodovotz, Y., & An, G. (2015). Chapter 3.2 Dynamic Knowledge Representation and the Power of Model Making. In Translational Systems Biology. (pp. 63-68).Elsevier. doi: 10.1016/b978-0-12-397884-4.00009-4.
Vodovotz, Y., & An, G. (2015). Chapter 3.1 Towards Translational Systems Biology of Inflammation. In Translational Systems Biology. (pp. 57-61).Elsevier. doi: 10.1016/b978-0-12-397884-4.00008-2.
Vodovotz, Y., & An, G. (2015). Chapter 2.4 Randomized Clinical Trials A Bridge Too Far?. In Translational Systems Biology. (pp. 35-40).Elsevier. doi: 10.1016/b978-0-12-397884-4.00005-7.
Vodovotz, Y., & An, G. (2015). Chapter 2.3 Biomedical Research Since the Molecular Revolution An Embarrassment of Riches. In Translational Systems Biology. (pp. 27-33).Elsevier. doi: 10.1016/b978-0-12-397884-4.00004-5.
Vodovotz, Y., & An, G. (2015). Chapter 3.3 A Roadmap for a Rational Future A Systematic Path for the Design and Implementation of New Therapeutics. In Translational Systems Biology. (pp. 69-78).Elsevier. doi: 10.1016/b978-0-12-397884-4.00010-0.
Vodovotz, Y., & An, G. (2015). Chapter 4.1 From Data to Knowledge in Translational Systems Biology An Overview of Computational Approaches Across the Scientific Cycle. In Translational Systems Biology. (pp. 81-88).Elsevier. doi: 10.1016/b978-0-12-397884-4.00011-2.
Vodovotz, Y., & An, G. (2015). Chapter 2.5 Complexity in Biomedical Research Mysticism Versus Methods. In Translational Systems Biology. (pp. 41-44).Elsevier. doi: 10.1016/b978-0-12-397884-4.00006-9.
Vodovotz, Y., & An, G. (2015). Chapter 2.1 A Brief History of the Philosophical Basis of the Scientific Endeavor How We Know What We Know, and How to Know More. In Translational Systems Biology. (pp. 11-19).Elsevier. doi: 10.1016/b978-0-12-397884-4.00002-1.
Vodovotz, Y., & An, G. (2015). Chapter 4.3 Mechanistic Modeling of Critical Illness Using Equations. In Translational Systems Biology. (pp. 99-110).Elsevier. doi: 10.1016/b978-0-12-397884-4.00013-6.
Vodovotz, Y., & An, G. (2015). Chapter 2.2 A Brief History of Biomedical Research up to the Molecular Biology Revolution. In Translational Systems Biology. (pp. 21-25).Elsevier. doi: 10.1016/b978-0-12-397884-4.00003-3.
Vodovotz, Y., & An, G. (2015). Chapter 2.6 Human Nature, Politics, and Translational Inertia. In Translational Systems Biology. (pp. 45-53).Elsevier. doi: 10.1016/b978-0-12-397884-4.00007-0.
Vodovotz, Y., & An, G. (2015). Chapter 1.1 Interesting Times The Translational Dilemma and the Need for Translational Systems Biology of Inflammation. In Translational Systems Biology. (pp. 3-8).Elsevier. doi: 10.1016/b978-0-12-397884-4.00001-x.
Wang, J., Vodovotz, Y., Fan, L., Li, Y., Liu, Z., Namas, R., Barclay, D., Zamora, R., Billiar, T.R., Wilson, M.A., Fan, J., & Jiang, Y. (2015). Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. FASEB J, 29(1), 250-262.Wiley. doi: 10.1096/fj.14-255992.
Wolf, M.T., Vodovotz, Y., Tottey, S., Brown, B.N., & Badylak, S.F. (2015). Predicting in vivo responses to biomaterials via combined in vitro and in silico analysis. Tissue Eng Part C Methods, 21(2), 148-159.SAGE Publications. doi: 10.1089/ten.TEC.2014.0167.
Zhu, X., Namas, R.A., Mi, Q., Abdul-Malak, O.M., Vodovotz, Y., Sperry, J., Feng, Q., & Billiar, T. (2015). CENTRAL ROLE OF CHEMOKINES IN MODULATING THE INFLAMMATORY RESPONSE IN TRAUMA-INDUCED COAGULOPATHY. SHOCK, 43(6), 100-101.
Ziraldo, C., Solovyev, A., Allegretti, A., Krishnan, S., Henzel, M.K., Sowa, G.A., Brienza, D., An, G., Mi, Q., & Vodovotz, Y. (2015). A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury. In Mac Gabhann, F. (Ed.). PLoS Comput Biol, 11(6), e1004309.Public Library of Science (PLoS). doi: 10.1371/journal.pcbi.1004309.
Zolin, S.J., Vodovotz, Y., Forsythe, R.M., Rosengart, M.R., Namas, R., Brown, J.B., Peitzman, A.P., Billiar, T.R., & Sperry, J.L. (2015). The early evolving sex hormone environment is associated with significant outcome and inflammatory response differences after injury. J Trauma Acute Care Surg, 78(3), 451-457.Wolters Kluwer. doi: 10.1097/TA.0000000000000550.
Aerts, J.M., Haddad, W.M., An, G., & Vodovotz, Y. (2014). From data patterns to mechanistic models in acute critical illness. J Crit Care, 29(4), 604-610.Elsevier. doi: 10.1016/j.jcrc.2014.03.018.
Azhar, N., & Vodovotz, Y. (2014). Innate immunity in disease: insights from mathematical modeling and analysis. Adv Exp Med Biol, 844, 227-243.Springer Nature. doi: 10.1007/978-1-4939-2095-2_11.
Bielekova, B., Vodovotz, Y., An, G., & Hallenbeck, J. (2014). How implementation of systems biology into clinical trials accelerates understanding of diseases. Front Neurol, 5, 102.Frontiers. doi: 10.3389/fneur.2014.00102.
Dutta-Moscato, J., Solovyev, A., Mi, Q., Nishikawa, T., Soto-Gutierrez, A., Fox, I.J., & Vodovotz, Y. (2014). A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression. Front Bioeng Biotechnol, 2(MAY), 18.Frontiers. doi: 10.3389/fbioe.2014.00018.
Emr, B., Sadowsky, D., Azhar, N., Gatto, L.A., An, G., Nieman, G.F., & Vodovotz, Y. (2014). Removal of inflammatory ascites is associated with dynamic modification of local and systemic inflammation along with prevention of acute lung injury: in vivo and in silico studies. Shock, 41(4), 317-323.Wolters Kluwer. doi: 10.1097/SHK.0000000000000121.
Huang, W., Vodovotz, Y., Kusturiss, M.B., Barclay, D., Greenwald, K., Boninger, M.L., Coen, P.M., Brienza, D., & Sowa, G. (2014). Identification of distinct monocyte phenotypes and correlation with circulating cytokine profiles in acute response to spinal cord injury: a pilot study. PM R, 6(4), 332-341.Wiley. doi: 10.1016/j.pmrj.2013.10.006.
Khalifian, S., Nicholson, Y., Ziraldo, C., Starzl, R., Schneeberger, S., Thomson, A., Brandacher, G., Vodovotz, Y., & Raimondi, G. (2014). Abstract 102: inflammatory mediators modulate alloreactive T cell susceptibility to immune-regulation in reconstructive transplantation. Plast Reconstr Surg, 133(3 Suppl), 117.Wolters Kluwer. doi: 10.1097/01.prs.0000444926.53453.9f.
Mathew, S., Bartels, J., Banerjee, I., & Vodovotz, Y. (2014). Global sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responses. J Theor Biol, 358, 132-148.Elsevier. doi: 10.1016/j.jtbi.2014.05.036.
Namas, R.A., Abdul-Malak, O.M., Mi, Q., Almahmoud, K.W., Zaaqoq, A.M., Barclay, D., Peitzman, A.B., Billiar, T., & Vodovotz, Y. (2014). ANALYSIS OF PRINCIPAL DRIVERS AND DYNAMIC NETWORKS OF SYSTEMIC INFLAMMATION SUGGESTS COMPLEX INTERACTION BETWEEN AGE AND INJURY SEVERITY. SHOCK, 41, 78.
Paranjpe, S., Fontes, P., Vodovotz, Y., & Michalopoulos, G. (2014). Gene network analysis of liver allografts preserved with machine perfusion (649.10). The FASEB Journal, 28(S1).Wiley. doi: 10.1096/fasebj.28.1_supplement.649.10.
Sperry, J.L., Zolin, S., Zuckerbraun, B.S., Vodovotz, Y., Namas, R., Neal, M.D., Ferrell, R.E., Rosengart, M.R., Peitzman, A.B., & Billiar, T.R. (2014). X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury. Ann Surg, 260(4), 698-703.Wolters Kluwer. doi: 10.1097/SLA.0000000000000918.
Vodovotz, Y. (2014). Computational modelling of the inflammatory response in trauma, sepsis and wound healing: implications for modelling resilience. Interface Focus, 4(5), 20140004.The Royal Society. doi: 10.1098/rsfs.2014.0004.
Wolfram, D., Starzl, R., Hackl, H., Barclay, D., Hautz, T., Zelger, B., Brandacher, G., Lee, W.P.A., Eberhart, N., Vodovotz, Y., Pratschke, J., Pierer, G., & Schneeberger, S. (2014). Insights from computational modeling in inflammation and acute rejection in limb transplantation. In Bueno, V. (Ed.). PLoS One, 9(6), e99926.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0099926.
Zaaqoq, A.M., Namas, R., Almahmoud, K., Azhar, N., Mi, Q., Zamora, R., Brienza, D.M., Billiar, T.R., & Vodovotz, Y. (2014). Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma. Crit Care Med, 42(6), 1487-1497.Wolters Kluwer. doi: 10.1097/CCM.0000000000000248.
Zhang, Y., Zhang, J., Korff, S., Ayoob, F., Vodovotz, Y., & Billiar, T.R. (2014). Delayed neutralization of interleukin 6 reduces organ injury, selectively suppresses inflammatory mediator, and partially normalizes immune dysfunction following trauma and hemorrhagic shock. Shock, 42(3), 218-227.Wolters Kluwer. doi: 10.1097/SHK.0000000000000211.
Zhu, X., Pribis, J.P., Rodriguez, P.C., Morris, S.M., Vodovotz, Y., Billiar, T.R., & Ochoa, J.B. (2014). The central role of arginine catabolism in T-cell dysfunction and increased susceptibility to infection after physical injury. Ann Surg, 259(1), 171-178.Wolters Kluwer. doi: 10.1097/SLA.0b013e31828611f8.
An, G., & Vodovotz, Y. (2013). The Rationale and Implementation of Translational Systems Biology as a New Paradigm for the Study of Inflammation. In Complex Systems and Computational Biology Approaches to Acute Inflammation. 9781461480082, (pp. 283-287).Springer Nature. doi: 10.1007/978-1-4614-8008-2_15.
Arciero, J., Bard Ermentrout, G., Siggers, R., Afrazi, A., Hackam, D., Vodovotz, Y., & Rubin, J. (2013). Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis. J Theor Biol, 321, 83-99.Elsevier. doi: 10.1016/j.jtbi.2012.12.002.
Azhar, N., Mi, Q., Ziraldo, C., Buliga, M., Constantine, G.M., & Vodovotz, Y. (2013). Integrating Data-Driven and Mechanistic Models of the Inflammatory Response in Sepsis and Trauma. In Complex Systems and Computational Biology Approaches to Acute Inflammation. 9781461480082, (pp. 143-157).Springer Nature. doi: 10.1007/978-1-4614-8008-2_8.
Azhar, N., Namas, R., Jefferson, B., Barclay, D., Zamora, R., & Vodovotz, Y. (2013). Combined network and mathematical modeling suggests novel inflammation positive feedback circuit and role for IL-1α in experimental trauma/hemorrhage and hepatocyte hypoxia. Journal of Critical Care, 28(1), e7.Elsevier. doi: 10.1016/j.jcrc.2012.10.029.
Azhar, N., Ziraldo, C., Barclay, D., Rudnick, D.A., Squires, R.H., Vodovotz, Y., & Pediatric Acute Liver Failure Study Group. (2013). Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. In Androulakis, I.P. (Ed.). PLoS One, 8(11), e78202.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0078202.
Barber, J., Tronzo, M., Harold Horvat, C., Clermont, G., Upperman, J., Vodovotz, Y., & Yotov, I. (2013). A three-dimensional mathematical and computational model of necrotizing enterocolitis. J Theor Biol, 322, 17-32.Elsevier. doi: 10.1016/j.jtbi.2012.11.018.
Christley, S., Emr, B., Ghosh, A., Satalin, J., Gatto, L., Vodovotz, Y., Nieman, G.F., & An, G. (2013). Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome. Phys Biol, 10(3), 036008.IOP Publishing. doi: 10.1088/1478-3975/10/3/036008.
Emr, B., Gatto, L.A., Roy, S., Satalin, J., Ghosh, A., Snyder, K., Andrews, P., Habashi, N., Marx, W., Ge, L., Wang, G., Dean, D.A., Vodovotz, Y., & Nieman, G. (2013). Airway pressure release ventilation prevents ventilator-induced lung injury in normal lungs. JAMA Surg, 148(11), 1005-1012.American Medical Association (AMA). doi: 10.1001/jamasurg.2013.3746.
Hoque, R., Vodovotz, Y., & Mehal, W. (2013). Therapeutic strategies in inflammasome mediated diseases of the liver. J Hepatol, 58(5), 1047-1052.Elsevier. doi: 10.1016/j.jhep.2012.12.017.
Lei, J., Vodovotz, Y., Tzeng, E., & Billiar, T.R. (2013). Nitric oxide, a protective molecule in the cardiovascular system. Nitric Oxide, 35, 175-185.Elsevier. doi: 10.1016/j.niox.2013.09.004.
Lindig, S., Hlich, E.F., König, R., Claus, R.A., Vodovotz, Y., & Bauer, M. (2013). Integrative “omic” analysis of organ-wide coregulation patterns highlights pathogen-dependent activation of 25-hydroxycholesterol during septic disease progression. Journal of Critical Care, 28(6), e42.Elsevier. doi: 10.1016/j.jcrc.2013.07.040.
Lindig, S., Quickert, S., Vodovotz, Y., Wanner, G.A., & Bauer, M. (2013). Age-independent co-expression of antimicrobial gene clusters in the blood of septic patients. Int J Antimicrob Agents, 42 Suppl(SUPPL.1), S2-S7.Elsevier. doi: 10.1016/j.ijantimicag.2013.04.012.
Mathew, S., Bartels, J., Banerjee, I., & Vodovotz, Y. (2013). Global sensitivity analysis of endotoxin-induced acute inflammatory responses predicts the multimodal dependence of global tissue damage both on host IL-6 responses and endotoxin dose. Journal of Critical Care, 28(1), e12-e13.Elsevier. doi: 10.1016/j.jcrc.2012.10.039.
Namas, R.A., Bartels, J., Hoffman, R., Barclay, D., Billiar, T.R., Zamora, R., & Vodovotz, Y. (2013). Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice. In Unutmaz, D. (Ed.). PLoS One, 8(7), e67419.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0067419.
Pakpour, N., Akman-Anderson, L., Vodovotz, Y., & Luckhart, S. (2013). The effects of ingested mammalian blood factors on vector arthropod immunity and physiology. Microbes Infect, 15(3), 243-254.Elsevier. doi: 10.1016/j.micinf.2013.01.003.
Price, I., Ermentrout, B., Zamora, R., Wang, B., Azhar, N., Mi, Q., Constantine, G., Faeder, J.R., Luckhart, S., & Vodovotz, Y. (2013). In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoes. J Theor Biol, 334, 173-186.Elsevier. doi: 10.1016/j.jtbi.2013.05.028.
Roy, S., Habashi, N., Sadowitz, B., Andrews, P., Ge, L., Wang, G., Roy, P., Ghosh, A., Kuhn, M., Satalin, J., Gatto, L.A., Lin, X., Dean, D.A., Vodovotz, Y., & Nieman, G. (2013). Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury. Shock, 39(1), 28-38.Wolters Kluwer. doi: 10.1097/SHK.0b013e31827b47bb.
Scheff, J.D., Mavroudis, P.D., Foteinou, P.T., An, G., Calvano, S.E., Doyle, J., Dick, T.E., Lowry, S.F., Vodovotz, Y., & Androulakis, I.P. (2013). A multiscale modeling approach to inflammation: A case study in human endotoxemia. JOURNAL OF COMPUTATIONAL PHYSICS, 244, 279-289.Elsevier. doi: 10.1016/j.jcp.2012.09.024.
Solovyev, A., Mi, Q., Tzen, Y.T., Brienza, D., & Vodovotz, Y. (2013). Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury. In Peirce, S.M. (Ed.). PLoS Comput Biol, 9(5), e1003070.Public Library of Science (PLoS). doi: 10.1371/journal.pcbi.1003070.
Starzl, R., Wolfram, D., Zamora, R., Jefferson, B., Barclay, D., Ho, C., Brandacher, G., Schneeberger, S., Lee, W.P.A., Carbonell, J., & Vodovotz, Y. (2013). Tissue-specific patterns of caspase-1 and cytokines in excisional wounds are altered by shock in rat skin and muscle. Journal of Critical Care, 28(1), e12.Elsevier. doi: 10.1016/j.jcrc.2012.10.038.
Stern, J.R., Ziraldo, C., Vodovotz, Y., & An, G. (2013). Agent-Based Models of Wound Healing. In Complex Systems and Computational Biology Approaches to Acute Inflammation. 9781461480082, (pp. 209-228).Springer Nature. doi: 10.1007/978-1-4614-8008-2_12.
Vodovotz, Y., & An, G. (2013). An Overview of the Translational Dilemma and the Need for Translational Systems Biology of Inflammation. In Complex Systems and Computational Biology Approaches to Acute Inflammation. 9781461480082, (pp. 1-7).Springer Nature. doi: 10.1007/978-1-4614-8008-2_1.
Vodovotz, Y., & An, G. (2013). Complex Systems and Computational Biology Approaches to Acute Inflammation. In Vodovotz, Y., & An, G. (Eds.). 9781461480082, v.Springer New York. doi: 10.1007/978-1-4614-8008-2.
Vodovotz, Y., & Billiar, T.R. (2013). In silico modeling: methods and applications to trauma and sepsis. Crit Care Med, 41(8), 2008-2014.Wolters Kluwer. doi: 10.1097/CCM.0b013e31829a6eb4.
Vodovotz, Y., An, G., & Androulakis, I.P. (2013). A Systems Engineering Perspective on Homeostasis and Disease. Front Bioeng Biotechnol, 1, 6.Frontiers. doi: 10.3389/fbioe.2013.00006.
Vodovotz, Y., Azhar, N., Miskov-Zivanov, N., Buliga, M., Zamora, R., Ermentrout, B., Constantine, G.M., Faeder, J.R., Pakpour, N., & Luckhart, S. (2013). Modeling Host–Vector–Pathogen Immuno-inflammatory Interactions in Malaria. In Complex Systems and Computational Biology Approaches to Acute Inflammation. 9781461480082, (pp. 265-279).Springer Nature. doi: 10.1007/978-1-4614-8008-2_14.
Vodovotz, Y., Bartels, J., & An, G. (2013). In Silico Trials and Personalized Therapy for Sepsis and Trauma. In Complex Systems and Computational Biology Approaches to Acute Inflammation. 9781461480082, (pp. 159-170).Springer Nature. doi: 10.1007/978-1-4614-8008-2_9.
Vodovotz, Y., Prelich, J., Lagoa, C., Barclay, D., Zamora, R., Murase, N., & Gandhi, C.R. (2013). Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo and in silico studies. Mol Med, 18(1), 1421-1429.Springer Nature. doi: 10.2119/molmed.2012.00183.
Zamora, R., Ziraldo, C., Namas, R., Almahmoud, K., Tapias, V., Mi, Q., Barclay, D., Jefferson, B., Chen, G., Billiar, T., & Vodovotz, Y. (2013). Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies. Journal of Critical Care, 28(6), e28.Elsevier. doi: 10.1016/j.jcrc.2013.07.005.
Zhang, M., Ueki, S., Kimura, S., Yoshida, O., Castellaneta, A., Ozaki, K.S., Demetris, A.J., Ross, M., Vodovotz, Y., Thomson, A.W., B Stolz, D., Geller, D.A., & Murase, N. (2013). Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury. Hepatology, 57(4), 1585-1596.Wolters Kluwer. doi: 10.1002/hep.26129.
Ziraldo, C., Mi, Q., An, G., & Vodovotz, Y. (2013). Computational Modeling of Inflammation and Wound Healing. Adv Wound Care (New Rochelle), 2(9), 527-537.SAGE Publications. doi: 10.1089/wound.2012.0416.
Ziraldo, C., Solovyev, A., Allegretti, A., Krishnan, S., Henzel, M.K., Sowa, G.A., Brienza, D., An, G., Mi, Q., & Vodovotz, Y. (2013). A computational, tissue-realistic model of pressure ulcer formation in individuals with spinal cord injury. Journal of Critical Care, 28(1), e23.Elsevier. doi: 10.1016/j.jcrc.2012.10.061.
Ziraldo, C., Vodovotz, Y., Namas, R.A., Almahmoud, K., Tapias, V., Mi, Q., Barclay, D., Jefferson, B.S., Chen, G., Billiar, T.R., & Zamora, R. (2013). Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies. In Androulakis, I.P. (Ed.). PLoS One, 8(12), e79804.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0079804.
An, G., Namas, R.A., & Vodovotz, Y. (2012). Sepsis: from pattern to mechanism and back. Crit Rev Biomed Eng, 40(4), 341-351.Begell House. doi: 10.1615/critrevbiomedeng.v40.i4.80.
An, G., Nieman, G., & Vodovotz, Y. (2012). Toward computational identification of multiscale "tipping points" in acute inflammation and multiple organ failure. Ann Biomed Eng, 40(11), 2414-2424.Springer Nature. doi: 10.1007/s10439-012-0565-9.
An, G., Nieman, G., & Vodovotz, Y. (2012). Computational and systems biology in trauma and sepsis: current state and future perspectives. Int J Burns Trauma, 2(1), 1-10.
Dangi, A., Sumpter, T.L., Kimura, S., Stolz, D.B., Murase, N., Raimondi, G., Vodovotz, Y., Huang, C., Thomson, A.W., & Gandhi, C.R. (2012). Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. J Immunol, 188(8), 3667-3677.Oxford University Press (OUP). doi: 10.4049/jimmunol.1102460.
Dick, T.E., Molkov, Y.I., Nieman, G., Hsieh, Y.H., Jacono, F.J., Doyle, J., Scheff, J.D., Calvano, S.E., Androulakis, I.P., An, G., & Vodovotz, Y. (2012). Linking Inflammation, Cardiorespiratory Variability, and Neural Control in Acute Inflammation via Computational Modeling. Front Physiol, 3, 222.Frontiers. doi: 10.3389/fphys.2012.00222.
Dutta-Moscato, J., Solovyev, A., Mi, Q., Nishikawa, T., Soto-Gutierrez, A., Fox, I., & Vodovotz, Y. (2012). A multiscale, agent-based model of liver inflammation, cirrhosis, and cancer. Journal of Critical Care, 27(3), e8.Elsevier. doi: 10.1016/j.jcrc.2012.01.026.
Gómez, H., Mesquida, J., Hermus, L., Polanco, P., Kim, H.K., Zenker, S., Torres, A., Namas, R., Vodovotz, Y., Clermont, G., Puyana, J.C., & Pinsky, M.R. (2012). Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated?. J Surg Res, 178(1), 358-369.Elsevier. doi: 10.1016/j.jss.2011.12.015.
Lee, J.S., Sperry, J.L., Ochoa, J.B., Barclay, D., Namas, R., Vodovotz, Y., & Rosengart, M.R. (2012). Persistence of elevated plasma CXCL8 concentrations following red blood cell transfusion in a trauma cohort. Shock, 37(4), 373-377.Wolters Kluwer. doi: 10.1097/SHK.0b013e31824bcb72.
Liu, L., Yannam, G.R., Nishikawa, T., Yamamoto, T., Basma, H., Ito, R., Nagaya, M., Dutta-Moscato, J., Stolz, D.B., Duan, F., Kaestner, K.H., Vodovotz, Y., Soto-Gutierrez, A., & Fox, I.J. (2012). The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis. Hepatology, 55(5), 1529-1539.Wolters Kluwer. doi: 10.1002/hep.24815.
Namas, R., Zamora, R.Namas, R., An, G., Doyle, J., Dick, T.E., Jacono, F.J., Androulakis, I.P., Nieman, G.F., Chang, S., Billiar, T.R., Kellum, J.A., Angus, D.C., & Vodovotz, Y. (2012). Sepsis: Something old, something new, and a systems view. J Crit Care, 27(3), 314.e1-314.11.Elsevier. doi: 10.1016/j.jcrc.2011.05.025.
Namas, R.A., Mikheev, M., Yin, J., Over, P., Young, M., Constantine, G.M., Zamora, R., Gerlach, J., & Vodovotz, Y. (2012). A Biohybrid Device for the Systemic Control of Acute Inflammation. Disrupt Sci Technol, 1(1), 20-27.SAGE Publications. doi: 10.1089/dst.2012.0001.
Namas, R.A., Namas, R., Lagoa, C., Barclay, D., Mi, Q., Zamora, R., Peng, Z., Wen, X., Fedorchak, M.V., Valenti, I.E., Federspiel, W.J., Kellum, J.A., & Vodovotz, Y. (2012). Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies. Mol Med, 18(1), 1366-1374.Springer Nature. doi: 10.2119/molmed.2012.00106.
Nieman, G., Brown, D., Sarkar, J., Kubiak, B., Ziraldo, C., Dutta-Moscato, J., Vieau, C., Barclay, D., Gatto, L., Maier, K., Constantine, G., Billiar, T.R., Zamora, R., Mi, Q., Chang, S., & Vodovotz, Y. (2012). A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Crit Care Med, 40(4), 1052-1063.Wolters Kluwer. doi: 10.1097/CCM.0b013e31823e986a.
Pribis, J.P., Zhu, X., Vodovotz, Y., & Ochoa, J.B. (2012). Systemic arginine depletion after a murine model of surgery or trauma. JPEN J Parenter Enteral Nutr, 36(1), 53-59.Wiley. doi: 10.1177/0148607111414579.
Roy, S., Bagchi, D., Raychaudhuri, S., & Vodovotz, Y. (2012). At the Interface between Acute and Chronic Inflammation. In Chronic Inflammation. (pp. 3-20).Taylor & Francis. doi: 10.1201/b12696-3.
Roy, S., Sadowitz, B., Andrews, P., Gatto, L.A., Marx, W., Ge, L., Wang, G., Lin, X., Dean, D.A., Kuhn, M., Ghosh, A., Satalin, J., Snyder, K., Vodovotz, Y., Nieman, G., & Habashi, N. (2012). Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury. J Trauma Acute Care Surg, 73(2), 391-400.Wolters Kluwer. doi: 10.1097/TA.0b013e31825c7a82.
Roy, S.K., Kubiak, B.D., Albert, S.P., Vieau, C.J., Gatto, L., Golub, L., Lee, H.M., Sookhu, S., Vodovotz, Y., & Nieman, G.F. (2012). Chemically modified tetracycline 3 prevents acute respiratory distress syndrome in a porcine model of sepsis + ischemia/reperfusion-induced lung injury. Shock, 37(4), 424-432.Wolters Kluwer. doi: 10.1097/SHK.0b013e318245f2f9.
Scheff, J.D., Doyle, J., Vodovotz, Y., & Androulakis, I.P. (2012). A stochastic analysis of the inflammatory response. Journal of Critical Care, 27(3), e6-e7.Elsevier. doi: 10.1016/j.jcrc.2012.01.024.
Schwacha, M.G., Jeschke, M.G., Vodovotz, Y., & Wang, D. (2012). International Journal of Burns and Trauma: Editorial Board (2012) e-Century Publishing Corporation. Int J Burns Trauma, 2(1), 68-70.
Sperry, J.L., Vodovotz, Y., Ferrell, R.E., Namas, R., Chai, Y.M., Feng, Q.M., Jia, W.P., Forsythe, R.M., Peitzman, A.B., & Billiar, T.R. (2012). Racial disparities and sex-based outcomes differences after severe injury. J Am Coll Surg, 214(6), 973-980.Wolters Kluwer. doi: 10.1016/j.jamcollsurg.2012.02.020.
Sumpter, T.L., Dangi, A., Matta, B.M., Huang, C., Stolz, D.B., Vodovotz, Y., Thomson, A.W., & Gandhi, C.R. (2012). Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. J Immunol, 189(8), 3848-3858.Oxford University Press (OUP). doi: 10.4049/jimmunol.1200819.
Weber, M., Lambeck, S., Ding, N., Henken, S., Kohl, M., Deigner, H.P., Enot, D.P., Igwe, E.I., Frappart, L., Kiehntopf, M., Claus, R.A., Kamradt, T., Weih, D., Vodovotz, Y., Briles, D.E., Ogunniyi, A.D., Paton, J.C., Maus, U.A., & Bauer, M. (2012). Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB J, 26(6), 2424-2436.Wiley. doi: 10.1096/fj.11-191957.
Zaaqoq, A., Namas, R., Almahmoud, K., Krishnan, S., Azhar, N., Ziraldo, C., Mi, Q., Zamora, R., Brienza, D., & Vodovotz, Y. (2012). MATHEMATICAL MODELING OF ALTERED INFLAMMATORY RESPONSE AFTER TRAUMATIC SPINAL CORD INJURY IN BLUNT TRAUMA. CRITICAL CARE MEDICINE, 40(12), U288.
Zaaqoq, A., Namas, R., Almahmoud, K., Krishnan, S., Azhar, N., Ziraldo, C., Mi, Q., Zamora, R., Brienza, D., & Vodovotz, Y. (2012). 1064. Critical Care Medicine, 40(12), 1-328.Wolters Kluwer. doi: 10.1097/01.ccm.0000425277.23257.03.
Zamora, R., Azhar, N., Namas, R., Metukuri, M.R., Clermont, T., Gladstone, C., Namas, R.A., Hermus, L., Megas, C., Constantine, G., Billiar, T.R., Fink, M.P., & Vodovotz, Y. (2012). Identification of a novel pathway of transforming growth factor-β1 regulation by extracellular NAD+ in mouse macrophages: in vitro and in silico studies. J Biol Chem, 287(37), 31003-31014.Elsevier. doi: 10.1074/jbc.M112.344309.
Zamora, R., Metukuri, M., Namas, R., Azhar, N., Namas, R., Constantine, G., Billiar, T., Fink, M., & Vodovotz, Y. (2012). Induction and activation of macrophage transforming growth factor-β1 by extracellular nicotinamide adenine dinucleotide (NAD+) and its metabolite, cyclic ADP ribose: In vitro and in silico studies. Journal of Critical Care, 27(3), e10.Elsevier. doi: 10.1016/j.jcrc.2012.01.030.
Ziraldo, C., Mi, Q., Barclay, D., Jefferson, B., Namas, R.A., Vodovotz, Y., & Zamora, R. (2012). CENTRAL INFLAMMATORY ROLE FOR MCP-1 IN HEPATOCYTES REVEALED BY IN VITRO AND IN SILICO STUDIES. SHOCK, 37, 110.
An, G., Bartels, J., & Vodovotz, Y. (2011). In Silico Augmentation of the Drug Development Pipeline: Examples from the study of Acute Inflammation. Drug Dev Res, 72(2), 187-200.Wiley. doi: 10.1002/ddr.20415.
Brown, B.N., Price, I.M., Toapanta, F.R., DeAlmeida, D.R., Wiley, C.A., Ross, T.M., Oury, T.D., & Vodovotz, Y. (2011). An agent-based model of inflammation and fibrosis following particulate exposure in the lung. Math Biosci, 231(2), 186-196.Elsevier. doi: 10.1016/j.mbs.2011.03.005.
Edmonds, R.D., Vodovotz, Y., Lagoa, C., Dutta-Moscato, J., Yang, Y., Fink, M.P., Levy, R.M., Prince, J.M., Kaczorowski, D.J., Tseng, G.C., & Billiar, T.R. (2011). Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis. Physiol Genomics, 43(20), 1170-1183.American Physiological Society. doi: 10.1152/physiolgenomics.00020.2011.
Ghuma, A., Giraldo, C., Namas, R., Ochoa, J., Billiar, T., Mi, Q., Zamora, R., & Vodovotz, Y. (2011). Data-driven segregation of trauma patients using principal component analysis yields novel, patient-specific insights into acute inflammation. Journal of Critical Care, 26(2), e2.Elsevier. doi: 10.1016/j.jcrc.2010.12.020.
Jha, S., Donze, A., Khandpur, R., Dutta-Moscato, J., Mi, Q., Vodovotz, Y., Clermont, G., & Langmead, C. (2011). Parameter estimation and synthesis for systems biology: New algorithms for nonlinear and stochastic models. Journal of Critical Care, 26(2), e8.Elsevier. doi: 10.1016/j.jcrc.2010.12.031.
Li, N.Y.K., Vodovotz, Y., Kim, K.H., Mi, Q., Hebda, P.A., & Abbott, K.V. (2011). Biosimulation of acute phonotrauma: an extended model. Laryngoscope, 121(11), 2418-2428.Wiley. doi: 10.1002/lary.22226.
Menzel, C.L., Pfeifer, R., Darwiche, S.S., Kobbe, P., Gill, R., Shapiro, R.A., Loughran, P., Vodovotz, Y., Scott, M.J., Zenati, M.S., Billiar, T.R., & Pape, H.C. (2011). Models of lower extremity damage in mice: time course of organ damage and immune response. J Surg Res, 166(2), e149-e156.Elsevier. doi: 10.1016/j.jss.2010.11.914.
Mi, Q., Constantine, G., Megas, C., Krishnan, S., Allegretti, A., Sowa, G., Brienza, D., & Vodovotz, Y. (2011). URINARY TRACT INFECTIONS PRECEDE PRESSURE ULCERS IN SPINAL CORD INJURY PATIENTS. WOUND REPAIR AND REGENERATION, 19(2), A39.
Mi, Q., Constantine, G., Ziraldo, C., Solovyev, A., Torres, A., Namas, R., Bentley, T., Billiar, T.R., Zamora, R., Puyana, J.C., & Vodovotz, Y. (2011). A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks. In El Khoury, J. (Ed.). PLoS One, 6(5), e19424.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0019424.
Mi, Q., Constantine, G., Ziraldo, C., Solovyev, A., Torres, A., Namas, R., Bentley, T., Zamora, R., Puyana, J.C., & Vodovotz, Y. (2011). Trauma/hemorrhage-induced inflammation in mice: Insights from data-driven models. Journal of Critical Care, 26(2), e7.Elsevier. doi: 10.1016/j.jcrc.2010.12.030.
Namas, R.A., Metukuri, M.R., Dhupar, R., Velosa, C., Jefferson, B.S., Myer, E., Constantine, G.M., Billiar, T.R., Vodovotz, Y., & Zamora, R. (2011). Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1α in mouse hepatocytes. Shock, 36(2), 196-202.Wolters Kluwer. doi: 10.1097/SHK.0b013e3182205e07.
Ramsgaard, L., Englert, J.M., Manni, M.L., Milutinovic, P.S., Gefter, J., Tobolewski, J., Crum, L., Coudriet, G.M., Piganelli, J., Zamora, R., Vodovotz, Y., Enghild, J.J., & Oury, T.D. (2011). Lack of the receptor for advanced glycation end-products attenuates E. coli pneumonia in mice. In Maus, U.A. (Ed.). PLoS One, 6(5), e20132.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0020132.
Schwacha, M.G., Jeschke, M.G., Vodovotz, Y., & Wang, D. (2011). Launching of international journal of burns and trauma. Int J Burns Trauma, 1(1), i.
Xiang, M., Yin, L., Li, Y., Xiao, G., Vodovotz, Y., Billiar, T.R., Wilson, M.A., & Fan, J. (2011). Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol, 44(3), 333-340.Oxford University Press (OUP). doi: 10.1165/rcmb.2009-0408OC.
Ziraldo, C., Ghuma, A., Namas, R., Ochoa, J., Billiar, T.R., Zamora, R., Mi, Q., & Vodovotz, Y. (2011). Early prediction of length of intensive care unit stay from inflammatory mediators in trauma patients. Journal of Critical Care, 26(2), e5-e6.Elsevier. doi: 10.1016/j.jcrc.2010.12.027.
Ziraldo, C., Mi, Q., Barclay, D., Namas, R., Billiar, T.R., Vodovotz, Y., & Zamora, R. (2011). THE DYNAMIC INFLAMMATORY RESPONSE OF PRIMARY MOUSE HEPATOCYTES TO HYPOXIA: PRINCIPAL DRIVERS AND NETWORKS. SHOCK, 35, 9.
Ziraldo, C., Solovyev, A., An, G., Mi, Q., & Vodovotz, Y. (2011). IDENTIFYING CLINICAL INTERVENTIONS AGAINST PRESSURE ULCER FORMATION IN SPINAL CORD INJURY PATIENTS: SENSITIVITY ANALYSIS OF AN AGENT-BASED MODEL. WOUND REPAIR AND REGENERATION, 19(2), A62.
Arciero, J.C., Ermentrout, G.B., Upperman, J.S., Vodovotz, Y., & Rubin, J.E. (2010). Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis. In Morty, R.E. (Ed.). PLoS One, 5(4), e10066.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0010066.
Constantine, G.M., Buliga, M., Vodovotz, Y., & Bohnen, N.I. (2010). TWO AUTOCOVARIANCE-BASED MEASURES OF BALANCE IN PARKINSONIANS AND NORMAL CONTROLS. Int J Pure Appl Math, 63(3), 269-278.
Edmonds, R.D., Tseng, G., Prince, J.M., Levy, R.M., Vodovotz, Y., & Billiar, T.R. (2010). Temporal Transcriptomic Response of Murine Liver to Trauma and Hemorrhagic Shock: A Dual Platform Microarray Analysis. Journal of Surgical Research, 158(2), 296-297.Elsevier. doi: 10.1016/j.jss.2009.11.763.
Li, N.Y.K., Abbott, K.V., Rosen, C., An, G., Hebda, P.A., & Vodovotz, Y. (2010). Translational systems biology and voice pathophysiology. Laryngoscope, 120(3), 511-515.Wiley. doi: 10.1002/lary.20755.
Li, N.Y.K., Vodovotz, Y., Hebda, P.A., & Abbott, K.V. (2010). Biosimulation of inflammation and healing in surgically injured vocal folds. Ann Otol Rhinol Laryngol, 119(6), 412-423.SAGE Publications. doi: 10.1177/000348941011900609.
Loughran, P.A., Bagci, E.Z., Zamora, R., Vodovotz, Y., & Billiar, T.R. (2010). Chapter 15 The Role of Nitric Oxide in Apoptosis and Autophagy Biochemical and Computational Studies. In Nitric Oxide. (pp. 513-537).Elsevier. doi: 10.1016/b978-0-12-373866-0.00015-0.
Loughran, P.A., Bagci, E.Z., Zamora, R., Vodovotz, Y., & Billiar, T.R. (2010). The Role of Nitric Oxide in Apoptosis and Autophagy. 513-537.Elsevier. doi: 10.1016/b978-0-12-373866-0.00015-0.
Martins-Green, M., Vodovotz, Y., & Liu, P. (2010). Systems biology applied to wound healing. Wound Repair Regen, 18(1), 1-2.Wiley. doi: 10.1111/j.1524-475X.2009.00567.x.
Mi, Q., Li, N.Y.K., Ziraldo, C., Ghuma, A., Mikheev, M., Squires, R., Okonkwo, D.O., Verdolini-Abbott, K., Constantine, G., An, G., & Vodovotz, Y. (2010). Translational systems biology of inflammation: potential applications to personalized medicine. Per Med, 7(5), 549-559.Taylor & Francis. doi: 10.2217/pme.10.45.
Prince, J.M., Vodovotz, Y., Baun, M.J., Monga, S.P., Billiar, T.R., & Gerlach, J.C. (2010). The nitric oxide donor S-nitrosoglutathione reduces apoptotic primary liver cell loss in a three-dimensional perfusion bioreactor culture model developed for liver support. Tissue Eng Part A, 16(3), 861-866.SAGE Publications. doi: 10.1089/ten.TEA.2009.0256.
Raimondi, G., Sumpter, T.L., Matta, B.M., Pillai, M., Corbitt, N., Vodovotz, Y., Wang, Z., & Thomson, A.W. (2010). Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol, 184(2), 624-636.Oxford University Press (OUP). doi: 10.4049/jimmunol.0900936.
Solovyev, A., Mikheev, M., Zhou, L., Dutta-Moscato, J., Ziraldo, C., An, G., Vodovotz, Y., & Mi, Q. (2010). SPARK: A Framework for Multi-Scale Agent-Based Biomedical Modeling. Int J Agent Technol Syst, 2(3), 18-30.IGI Global. doi: 10.4018/jats.2010070102.
Starzl, R., Brandacher, G., Wolfram, D., Barclay, D., Vodovotz, Y., Wang, Y., Gorantla, V.S., Pratschke, J., Lee, W.P.A., & Schneeberger, S. (2010). ANALYSIS OF GENETIC AND PROTEOMIC FACTORS OF THE IMMUNE RESPONSE MEDIATING CELLULAR INFILTRATION AND TRAFFICKING IN SKIN REJECTION OF COMPOSITE TISSUE ALLOGRAFTS. Transplantation, 90, 490.Wolters Kluwer. doi: 10.1097/00007890-201007272-00910.
Starzl, R., Wolfram, D., Brandacher, G., Wang, Y., Barclay, D., Vodovotz, Y., Pratschke, J., Lee, W.P.A., & Schneeberger, S. (2010). ALLOGENEIC AND SYNGENEIC CYTOKINE NETWORKS IN SKIN MUSCLE AND COMPOSITE TISSUE ALLOGRAFTS. Transplantation, 90, 489.Wolters Kluwer. doi: 10.1097/00007890-201007272-00907.
Tyagi, P., Barclay, D., Zamora, R., Yoshimura, N., Peters, K., Vodovotz, Y., & Chancellor, M. (2010). Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study. Int Urol Nephrol, 42(3), 629-635.Springer Nature. doi: 10.1007/s11255-009-9647-5.
Vodovotz, Y. (2010). Translational systems biology of inflammation and healing. Wound Repair Regen, 18(1), 3-7.Wiley. doi: 10.1111/j.1524-475X.2009.00566.x.
Vodovotz, Y., & An, G. (2010). Systems biology and inflammation. Methods Mol Biol, 662, 181-201.Springer Nature. doi: 10.1007/978-1-60761-800-3_9.
Vodovotz, Y., & An, G. (2010). Systems biology and inflammation. Methods in molecular biology (Clifton, N.J.), 662, 181-201.
Vodovotz, Y., Constantine, G., Faeder, J., Mi, Q., Rubin, J., Bartels, J., Sarkar, J., Squires, R.H., Okonkwo, D.O., Gerlach, J., Zamora, R., Luckhart, S., Ermentrout, B., & An, G. (2010). Translational systems approaches to the biology of inflammation and healing. Immunopharmacol Immunotoxicol, 32(2), 181-195.Taylor & Francis. doi: 10.3109/08923970903369867.
An, G., Mi, Q., Dutta-Moscato, J., & Vodovotz, Y. (2009). Agent-based models in translational systems biology. Wiley Interdiscip Rev Syst Biol Med, 1(2), 159-171.Wiley. doi: 10.1002/wsbm.45.
Constantine, G., Susick, E., Mi, Q., Solovyev, A., Okonkwo, D., & Vodovotz, Y. (2009). Data-driven modeling approaches for predicting outcomes following traumatic brain injury. Journal of Critical Care, 24(3), e24-e25.Elsevier. doi: 10.1016/j.jcrc.2009.06.027.
Constantine, G.M., Bartels, J., Chow, C.C., Clermont, G., & Vodovotz, Y. (2009). A linear code parameter search algorithm with applications to immunology. COMPUTATIONAL OPTIMIZATION AND APPLICATIONS, 42(1), 155-171.Springer Nature. doi: 10.1007/s10589-007-9118-9.
Edmonds, R.D., Lagoa, C.E., Prince, J.M., Levy, R.M., Tseng, G., Vodovotz, Y., & Billiar, T.R. (2009). QS385. Temporal Transcriptomic Response of Murine Liver to Severe Injury and Hemorrhagic Shock. Journal of Surgical Research, 151(2), 300.Elsevier. doi: 10.1016/j.jss.2008.11.695.
Ghuma, A., Namas, R., Ziraldo, C., Ochoa, J., Billiar, T.R., Zamora, R., Mi, Q., & Vodovotz, Y. (2009). Principal component analysis delineates both subgroup- and patient-specific insights into acute inflammation in trauma patients. Journal of Critical Care, 24(3), e24.Elsevier. doi: 10.1016/j.jcrc.2009.06.026.
Li, Y., Xiang, M., Vodovotz, Y., Billiar, T.R., Wilson, M.A., & Fan, J. (2009). ROLE OF HMGB1-TLR2 SIGNALING IN HEMORRHAGIC SHOCK-AUGMENTED ICAM-1 EXPRESSION IN LUNG ENDOTHELIAL CELLS. SHOCK, 32, 10.
Li, Y., Xiang, M., Yuan, Y., Xiao, G., Zhang, J., Jiang, Y., Vodovotz, Y., Billiar, T.R., Wilson, M.A., & Fan, J. (2009). Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. Am J Physiol Regul Integr Comp Physiol, 297(6), R1670-R1680.American Physiological Society. doi: 10.1152/ajpregu.00445.2009.
Liu, Y., Yuan, Y., Li, Y., Zhang, J., Xiao, G., Vodovotz, Y., Billiar, T.R., Wilson, M.A., & Fan, J. (2009). Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol, 182(1), 572-580.Oxford University Press (OUP). doi: 10.4049/jimmunol.182.1.572.
Metukuri, M.R., Beer-Stolz, D., Namas, R.A., Dhupar, R., Torres, A., Loughran, P.A., Jefferson, B.S., Tsung, A., Billiar, T.R., Vodovotz, Y., & Zamora, R. (2009). Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress. Am J Physiol Gastrointest Liver Physiol, 296(3), G499-G509.American Physiological Society. doi: 10.1152/ajpgi.90526.2008.
Metukuri, M.R., Namas, R., Gladstone, C., Clermont, T., Jefferson, B., Barclay, D., Hermus, L., Billiar, T.R., Zamora, R., & Vodovotz, Y. (2009). Activation of latent transforming growth factor-beta1 by nitric oxide in macrophages: role of soluble guanylate cyclase and MAP kinases. Wound Repair Regen, 17(4), 578-588.Wiley. doi: 10.1111/j.1524-475X.2009.00509.x.
Mikheev, M., Solovyev, A., Maltsev, A., Bartels, J., Chang, S., Mi, Q., & Vodovotz, Y. (2009). A parallel implementation of an agent-based modeling platform with application in modeling calcium releases in cardiomyocytes. Journal of Critical Care, 24(3), e21.Elsevier. doi: 10.1016/j.jcrc.2009.06.021.
Namas, R., Barclay, D., Ziraldo, C., Mi, Q., Billiar, T.R., Vodovotz, Y., & Zamora, R. (2009). HEPATOCYTES ARE A SOURCE OF CHEMOKINES RELEVANT TO THE HEPATIC RESPONSE TO HYPOXIA AND HEMORRHAGIC SHOCK. SHOCK, 32, 15.
Namas, R., Ghuma, A., Hermus, L., Zamora, R., Okonkwo, D.O., Billiar, T.R., & Vodovotz, Y. (2009). The acute inflammatory response in trauma / hemorrhage and traumatic brain injury: current state and emerging prospects. Libyan J Med, 4(3), 97-103.Taylor & Francis. doi: 10.4176/090325.
Namas, R., Ghuma, A., Torres, A., Polanco, P., Gomez, H., Barclay, D., Gordon, L., Zenker, S., Kim, H.K., Hermus, L., Zamora, R., Rosengart, M.R., Clermont, G., Peitzman, A., Billiar, T.R., Ochoa, J., Pinsky, M.R., Puyana, J.C., & Vodovotz, Y. (2009). An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage. In Ojcius, D.M. (Ed.). PLoS One, 4(12), e8406.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0008406.
Qi, M., Constantine, G., Solovyev, A., Susick, E., Okonkw, D., & Vodovotz, Y. (2009). Patient-specific mathematical models of traumatic brain injury. Journal of Critical Care, 24(3), e20.Elsevier. doi: 10.1016/j.jcrc.2009.06.018.
Rivière, B., Epshteyn, Y., Swigon, D., & Vodovotz, Y. (2009). A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior. Math Biosci, 217(1), 19-26.Elsevier. doi: 10.1016/j.mbs.2008.10.002.
Sarkar, J., Marathe, D., Inglis, A., Hurst, K., Kellum, J., Angus, D., Vodovotz, Y., & Chang, S. (2009). Mathematical modeling of community-acquired pneumonia patients. Critical Care, 13(Suppl 4), p49.Springer Nature. doi: 10.1186/cc8105.
Scott, M.J., Liu, S., Shapiro, R.A., Vodovotz, Y., & Billiar, T.R. (2009). Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism. Hepatology, 49(5), 1695-1708.Wolters Kluwer. doi: 10.1002/hep.22839.
Smaldone, M.C., Vodovotz, Y., Tyagi, V., Barclay, D., Philips, B.J., Yoshimura, N., Chancellor, M.B., & Tyagi, P. (2009). Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Urology, 73(2), 421-426.Elsevier. doi: 10.1016/j.urology.2008.07.031.
Torres, A., Bentley, T., Bartels, J., Sarkar, J., Barclay, D., Namas, R., Constantine, G., Zamora, R., Puyana, J.C., & Vodovotz, Y. (2009). Mathematical modeling of posthemorrhage inflammation in mice: studies using a novel, computer-controlled, closed-loop hemorrhage apparatus. Shock, 32(2), 172-178.Wolters Kluwer. doi: 10.1097/SHK.0b013e318193cc2b.
Tyagi, P., Jacobs, B.L., Barcaly, D., Vodovotz, Y., Leng, W.W., Kuo, H.C., & Chancellor, M.B. (2009). URINE LEVELS OF INFLAMMATORY CHEMOKINES CAN BE NOVEL BIOMARKERS FOR THE OVERACTIVE BLADDER. Journal of Urology, 181(4), 588.Wolters Kluwer. doi: 10.1016/s0022-5347(09)61656-6.
Tyagi, P., Tyagi, V., Yoshimura, N., Witteemer, E., Barclay, D., Loughran, P.A., Zamora, R., & Vodovotz, Y. (2009). Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis. J Inflamm (Lond), 6(1), 23.Springer Nature. doi: 10.1186/1476-9255-6-23.
Vodovotz, Y., Chang, S., Barclay, D., Kubiak, B., Vieau, C., Gatto, L., Maier, K., Ziraldo, C., Mi, Q., Zamora, R., & Nieman, G. (2009). Porcine endotoxemia: Multiplexed cytokine analysis and mathematical modeling. Journal of Critical Care, 24(3), e23.Elsevier. doi: 10.1016/j.jcrc.2009.06.024.
Vodovotz, Y., Constantine, G., Rubin, J., Csete, M., Voit, E.O., & An, G. (2009). Mechanistic simulations of inflammation: current state and future prospects. Math Biosci, 217(1), 1-10.Elsevier. doi: 10.1016/j.mbs.2008.07.013.
Wognum, S., Lagoa, C.E., Nagatomi, J., Sacks, M.S., & Vodovotz, Y. (2009). An exploratory pathways analysis of temporal changes induced by spinal cord injury in the rat bladder wall: insights on remodeling and inflammation. In Peccoud, J. (Ed.). PLoS One, 4(6), e5852.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0005852.
Wolfram, D., Starzl, R., Barclay, D., Vodovotz, Y., Levine, L., Wang, Y., Gorantla, V., Brandacher, G., Lee, A., & Schneeberger, S. (2009). OP25: A COMPUTATIONAL MODEL TO PROFILE CYTOKINE NETWORKS MEDIATING ACUTE REJECTION AFTER COMPOSITE TISSUE ALLOTRANSPLANTATION. Plastic & Reconstructive Surgery, 124(2S), 687-688.Wolters Kluwer. doi: 10.1097/01.prs.0000358929.94213.78.
Zenker, S., Polanco, P.M., Torres, A., Clermont, G., Kim, H.K., Vodovotz, Y., Pinsky, M.R., Namas, R.A., & Puyana, J.C. (2009). Very low frequency variability in the peripheral circulation: the possibility of plethysmographic quantification. Eur J Anaesthesiol, 26(6), 522-524.Wolters Kluwer. doi: 10.1097/EJA.0b013e3283297539.
AKMAN-ANDERSON, L., VODOVOTZ, Y., ZAMORA, R., & LUCKHART, S. (2008). 7 BLOODFEEDING AS AN INTERFACE OF MAMMALIAN AND ARTHROPOD IMMUNITY. In Insect Immunology. (pp. 151-179).Elsevier. doi: 10.1016/b978-012373976-6.50009-4.
AKMAN-ANDERSON, L., VODOVOTZ, Y., ZAMORA, R., & LUCKHART, S. (2008). BLOODFEEDING AS AN INTERFACE OF MAMMALIAN AND ARTHROPOD IMMUNITY. In Insect Immunology. (pp. 151-179).Elsevier. doi: 10.1016/b978-012373976-6.50009-4.
An, G., Faeder, J., & Vodovotz, Y. (2008). Translational systems biology: introduction of an engineering approach to the pathophysiology of the burn patient. J Burn Care Res, 29(2), 277-285.Oxford University Press (OUP). doi: 10.1097/BCR.0b013e31816677c8.
Bagci, E.Z., Vodovotz, Y., Billiar, T.R., Ermentrout, B., & Bahar, I. (2008). Computational insights on the competing effects of nitric oxide in regulating apoptosis. In Maedler, K. (Ed.). PLoS One, 3(5), e2249.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0002249.
Barclay, D., Zamora, R., Torres, A., Namas, R., Steed, D., & Vodovotz, Y. (2008). A simple, rapid, and convenient Luminex-compatible method of tissue isolation. J Clin Lab Anal, 22(4), 278-281.Wiley. doi: 10.1002/jcla.20253.
Brown, B., Price, I., Chu, Y., Konduru, N., Clermont, G., & Vodovotz, Y. (2008). Agent-based model of lung inflammation. Journal of Critical Care, 23(2), 263-264.Elsevier. doi: 10.1016/j.jcrc.2008.03.008.
Daun, S., Rubin, J., Vodovotz, Y., & Clermont, G. (2008). Equation-based models of dynamic biological systems. J Crit Care, 23(4), 585-594.Elsevier. doi: 10.1016/j.jcrc.2008.02.003.
Daun, S., Rubin, J., Vodovotz, Y., Roy, A., Parker, R., & Clermont, G. (2008). An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: results from parameter space reduction. J Theor Biol, 253(4), 843-853.Elsevier. doi: 10.1016/j.jtbi.2008.04.033.
Drexler, A.L., Vodovotz, Y., & Luckhart, S. (2008). Plasmodium development in the mosquito: biology bottlenecks and opportunities for mathematical modeling. Trends Parasitol, 24(8), 333-336.Elsevier. doi: 10.1016/j.pt.2008.05.005.
Kobbe, P., Kaczorowski, D.J., Vodovotz, Y., Tzioupis, C.H., Mollen, K.P., Billiar, T.R., & Pape, H.C. (2008). Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury. Shock, 30(6), 686-691.Wolters Kluwer. doi: 10.1097/SHK.0b013e31816f257e.
Kobbe, P., Vodovotz, Y., Kaczorowski, D.J., Billiar, T.R., & Pape, H.C. (2008). The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture. J Orthop Trauma, 22(6), 385-390.Wolters Kluwer. doi: 10.1097/BOT.0b013e318175dd88.
Kobbe, P., Vodovotz, Y., Kaczorowski, D.J., Mollen, K.P., Billiar, T.R., & Pape, H.C. (2008). Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture. SHOCK, 30(1), 43-47.Wolters Kluwer. doi: 10.1097/SHK.0b013e318d190b.
Kobbe, P., Vodovotz, Y., Kaczorowski, D.J., Mollen, K.P., Billiar, T.R., & Pape, H.C. (2008). Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture. Shock, 30(1), 43-47.Wolters Kluwer. doi: 10.1097/SHK.0b013e31815d190b.
Kumar, R., Chow, C.C., Bartels, J.D., Clermont, G., & Vodovotz, Y. (2008). A mathematical simulation of the inflammatory response to anthrax infection. Shock, 29(1), 104-111.Wolters Kluwer. doi: 10.1097/SHK.0b013e318067da56.
Kumar, R., Chow, C.C., Bartels, J.D., Clermont, G., & Vodovotz, Y. (2008). A MATHEMATICAL SIMULATION OF THE INFLAMMATORY RESPONSE TO ANTHRAX INFECTION. Shock, 29(1), 104-111.Wolters Kluwer. doi: 10.1097/shk.0b013e318067dcfe.
Li, N.Y.K., Verdolini, K., Clermont, G., Mi, Q., Rubinstein, E.N., Hebda, P.A., & Vodovotz, Y. (2008). A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. In Csete, M. (Ed.). PLoS One, 3(7), e2789.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0002789.
Luckhart, S., Lieber, M.J., Singh, N., Zamora, R., & Vodovotz, Y. (2008). Low levels of mammalian TGF-beta1 are protective against malaria parasite infection, a paradox clarified in the mosquito host. Exp Parasitol, 118(2), 290-296.Elsevier. doi: 10.1016/j.exppara.2007.08.013.
Mollen, K.P., Levy, R.M., Prince, J.M., Hoffman, R.A., Scott, M.J., Kaczorowski, D.J., Vallabhaneni, R., Vodovotz, Y., & Billiar, T.R. (2008). Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. J Leukoc Biol, 83(1), 80-88.Oxford University Press (OUP). doi: 10.1189/jlb.0407201.
Namas, R., Ghuma, A., Hermus, L., Zamora, R., Okonkwo, D.O., Billiar, T.R., & Vodovotz, Y. (2008). The Acute Inflammatory Response in Trauma /Hemorrhage and Traumatic Brain Injury: Current State and Emerging Prospects. Libyan Journal of Medicine, 4(3), 97-103.Taylor & Francis. doi: 10.3402/ljm.v4i3.4824.
Popovic, P.J., Vodovotz, Y., Morris, S.M., Munera, V., & Ochoa, J.B. (2008). QS402. IL-6 Synergizes With T Helper II Cytokines to Up-Regulate Arginase I in Spleen Myeloid Suppressor Cells Following Traumatic Stress. Journal of Surgical Research, 144(2), 427.Elsevier. doi: 10.1016/j.jss.2007.12.658.
Sarkar, J., Chang, S., Zenati, M., Ochoa, J., Billiar, T.R., & Vodovotz, Y. (2008). Computational simulation of individual inflammation and outcomes in trauma patients. Journal of Critical Care, 23(2), 263.Elsevier. doi: 10.1016/j.jcrc.2008.03.007.
Vodovotz, Y., Csete, M., Bartels, J., Chang, S., & An, G. (2008). Translational systems biology of inflammation. In McEntyre, J. (Ed.). PLoS Comput Biol, 4(4), e1000014.Public Library of Science (PLoS). doi: 10.1371/journal.pcbi.1000014.
An, G., Hunt, C.A., Clermont, G., Neugebauer, E., & Vodovotz, Y. (2007). Challenges and rewards on the road to translational systems biology in acute illness: four case reports from interdisciplinary teams. J Crit Care, 22(2), 169-175.Elsevier. doi: 10.1016/j.jcrc.2006.12.011.
Clermont, G., Vodovotz, Y., & Rubin, J. (2007). Equation-Based Models of Dynamic Biological Systems. In Endothelial Biomedicine. (pp. 1780-1785).Cambridge University Press (CUP). doi: 10.1017/cbo9780511546198.192.
Day, J., Rubin, J., Vodovotz, Y., Chow, C., & Clermont, G. (2007). Using nonlinear model predictive control to optimize inflammation-modulating therapy. Journal of Critical Care, 22(4), 350-351.Elsevier. doi: 10.1016/j.jcrc.2007.10.035.
Epshteyn, Y., Riviere, B., Swigon, D., & Vodovotz, Y. (2007). A simple mathematical model of lipopolysaccharide signaling through toll-like receptor 4 results in complex insights on preconditioning. Journal of Critical Care, 22(4), 333-335.Elsevier. doi: 10.1016/j.jcrc.2007.10.006.
Fan, J., Li, Y., Levy, R.M., Fan, J.J., Hackam, D.J., Vodovotz, Y., Yang, H., Tracey, K.J., Billiar, T.R., & Wilson, M.A. (2007). Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol, 178(10), 6573-6580.Oxford University Press (OUP). doi: 10.4049/jimmunol.178.10.6573.
Fan, J., Li, Y., Vodovotz, Y., Billiar, T.R., & Wilson, M.A. (2007). Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS. Shock, 28(2), 213-218.Wolters Kluwer. doi: 10.1097/shk.0b013e318033ec9d.
Kaczorowski, D.J., Mollen, K.P., Levy, R.M., Prince, J.M., Vallabhaneni, R., Liu, S., Yang, R., Vodovotz, Y., Fink, M.P., & Billiar, T.R. (2007). 63 Post-traumatic bacterial translocation (BT) is toll-like receptor 4 (TLR4) dependent but does not drive the inflammatory response. Journal of Surgical Research, 137(2), 176-177.Elsevier. doi: 10.1016/j.jss.2006.12.074.
Lagoa, C., Prince, J., Levy, R., Vodovotz, Y., Tseng, G., Yang, Y., Heckman, C., Fink, M.P., & Billiar, T.R. (2007). A temporal analysis of the hepatic transcriptomic response to bone fracture and hemorrhagic shock in mice. Journal of Critical Care, 22(4), 335.Elsevier. doi: 10.1016/j.jcrc.2007.10.007.
Lei, J., Dai, Y., Vodovotz, Y., & Billiar, T.R. (2007). Transgene is tightly regulated by Geneswitch system in 293 cells. The FASEB Journal, 21(6), lb72.Wiley. doi: 10.1096/fasebj.21.6.lb72-a.
Levy, R.M., Mollen, K.P., Prince, J.M., Kaczorowski, D.J., Vallabhaneni, R., Liu, S., Tracey, K.J., Lotze, M.T., Hackam, D.J., Fink, M.P., Vodovotz, Y., & Billiar, T.R. (2007). Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol, 293(4), R1538-R1544.American Physiological Society. doi: 10.1152/ajpregu.00272.2007.
Li, N.Y.K., Wognum, S., Ravin, K., & Vodovotz, Y. (2007). Agent-based simulation of urinary tract infection leading to renal scarring. Journal of Critical Care, 22(4), 336.Elsevier. doi: 10.1016/j.jcrc.2007.10.010.
Mi, Q., Rivière, B., Clermont, G., Steed, D.L., & Vodovotz, Y. (2007). Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1. Wound Repair Regen, 15(5), 671-682.Wiley. doi: 10.1111/j.1524-475X.2007.00271.x.
Mi, Q., Swigon, D., Rivière, B., Cetin, S., Vodovotz, Y., & Hackam, D.J. (2007). One-dimensional elastic continuum model of enterocyte layer migration. Biophys J, 93(11), 3745-3752.Elsevier. doi: 10.1529/biophysj.107.112326.
Mollen, K.P., Levy, R.M., Prince, J.M., Kaczorowski, D.J., Scott, M.J., Hoffman, R.A., Vodovotz, Y., Fink, M.P., & Billiar, T.R. (2007). 66 Systemic inflammation and end organ injury after peripheral tissue injury requires functional TLR4 on bone marrow-derived cells. Journal of Surgical Research, 137(2), 178.Elsevier. doi: 10.1016/j.jss.2006.12.077.
Pancoska, P., & Vodovotz, Y. (2007). A thermodynamic tolerance assessment of single nucleotide polymorphisms relevant to acute inflammation and coagulation. Journal of Critical Care, 22(4), 335-336.Elsevier. doi: 10.1016/j.jcrc.2007.10.009.
Pechersky, Y., Rasmussen, K., Nesdore, V., Mi, Q., & Vodovotz, Y. (2007). Agent-based simulation of bacterial sepsis: a teaching tool for science students. Journal of Critical Care, 22(4), 336-337.Elsevier. doi: 10.1016/j.jcrc.2007.10.011.
Price, I., Parikh, N., Ermentrout, Vodovotz, Y., & Luckhart, S. (2007). Oscillations of NO synthase in the midgut of the Anopheles mosquito. Journal of Critical Care, 22(4), 344-345.Elsevier. doi: 10.1016/j.jcrc.2007.10.024.
Prince, J.M., Ming, M.J., Levy, R.M., Liu, S., Pinsky, D.J., Vodovotz, Y., & Billiar, T.R. (2007). Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock. Shock, 27(2), 157-164.Wolters Kluwer. doi: 10.1097/01.shk.0000245025.01365.8e.
Upperman, J.S., Camerini, V., Lugo, B., Yotov, I., Sullivan, J., Rubin, J., Clermont, G., Zamora, R., Ermentrout, G.B., Ford, H.R., & Vodovotz, Y. (2007). Mathematical modeling in necrotizing enterocolitis--a new look at an ongoing problem. J Pediatr Surg, 42(3), 445-453.Elsevier. doi: 10.1016/j.jpedsurg.2006.10.053.
Vodovotz, Y., Clermont, G., Hunt, C.A., Lefering, R., Bartels, J., Seydel, R., Hotchkiss, J., Ta'asan, S., Neugebauer, E., & An, G. (2007). Evidence-based modeling of critical illness: an initial consensus from the Society for Complexity in Acute Illness. J Crit Care, 22(1), 77-84.Elsevier. doi: 10.1016/j.jcrc.2006.12.001.
Zenker, S., Polanco, P.M., Kim, H.K., Torres, A., Vodovotz, Y., Clermont, G., Pinsky, M.R., Severyn, D.A., & Puyana, J.C. (2007). Thresholded area over the curve of spectrometric tissue oxygen saturation as an indicator of volume resuscitability in porcine hemorrhagic shock. J Trauma, 63(3), 573-578.Wolters Kluwer. doi: 10.1097/TA.0b013e31812f6095.
Bagci, E.Z., Vodovotz, Y., Billiar, T.R., Ermentrout, G.B., & Bahar, I. (2006). Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophys J, 90(5), 1546-1559.Elsevier. doi: 10.1529/biophysj.105.068122.
Daun, S., Federspiel, W.J., DiLeo, M.V., Vodovotz, Y., Chang, S., Barterls, J., Peng, Z., Capponi, V., Wagner, W., Winchester, J., Clermont, G., & Kellum, J.A. (2006). Optimizing a therapeutic intervention: systems engineering of a pheresis intervention for sepsis. Journal of Critical Care, 21(4), 360-361.Elsevier. doi: 10.1016/j.jcrc.2006.10.033.
Day, J., Rubin, J., Vodovotz, Y., Chow, C.C., Reynolds, A., & Clermont, G. (2006). A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration. J Theor Biol, 242(1), 237-256.Elsevier. doi: 10.1016/j.jtbi.2006.02.015.
Fan, J., Li, Y., Vodovotz, Y., Billiar, T.R., & Wilson, M.A. (2006). Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. Am J Physiol Lung Cell Mol Physiol, 290(4), L738-L746.American Physiological Society. doi: 10.1152/ajplung.00280.2005.
Lagoa, C.E., Bartels, J., Baratt, A., Clermont, G., Fink, M.P., Billiar, T.R., & Vodovotz, Y. (2006). From mice to rats: interspecies prediction of the systemic inflammatory response using mathematical simulations. Journal of Critical Care, 21(4), 355-356.Elsevier. doi: 10.1016/j.jcrc.2006.10.022.
Lagoa, C.E., Bartels, J., Baratt, A., Tseng, G., Clermont, G., Fink, M.P., Billiar, T.R., & Vodovotz, Y. (2006). The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis. Shock, 26(6), 592-600.Wolters Kluwer. doi: 10.1097/01.shk.0000232272.03602.0a.
Levy, R.M., Prince, J.M., Mollen, K.P., Yang, R., Fink, M., Vodovotz, Y., & Billiar, T. (2006). Systemic inflammation and liver dysfunction after trauma is Toll-like receptor 4 (TLR-4) dependent. Journal of Surgical Research, 130(2), 173.Elsevier. doi: 10.1016/j.jss.2005.11.037.
Levy, R.M., Prince, J.M., Yang, R., Mollen, K.P., Liao, H., Watson, G.A., Fink, M.P., Vodovotz, Y., & Billiar, T.R. (2006). Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol, 291(4), R970-R976.American Physiological Society. doi: 10.1152/ajpregu.00793.2005.
Li, N.Y.K., Verdolini, K., Clermont, G., Mi, Q., Hebda, P.A., & Vodovotz, Y. (2006). Agent-based simulation of acute phonotrauma in cases with various cytokine profiles. Journal of Critical Care, 21(4), 347.Elsevier. doi: 10.1016/j.jcrc.2006.10.009.
Mollen, K.P., Prince, J., Levy, R., Scott, M., Watson, G., Kaczorowski, D., Kohut, L.K., Rosemary, H., Vodovotz, Y., & Billiar, T. (2006). TLR4-competent hematopoietic cells are required for systemic inflammation and hepatic injury after trauma/hemorrhage. Journal of the American College of Surgeons, 203(3), s42.Wolters Kluwer. doi: 10.1016/j.jamcollsurg.2006.05.098.
Prince, J.M., Baun, M.J., Vallabhaneni, R., Hout, M.S., Vodovotz, Y., Monga, S., Gerlach, J.C., & Billiar, T.R. (2006). Towards an improved extracorporeal liver support device: Nitric oxide (NO) inhibits apoptotic liver cell death in a four compartment bioreactor culture model. Journal of Surgical Research, 130(2), 208-209.Elsevier. doi: 10.1016/j.jss.2005.11.133.
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Prince, J.M., Levy, R.M., Yang, R., Mollen, K.P., Fink, M.P., Vodovotz, Y., & Billiar, T.R. (2006). Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg, 202(3), 407-417.Wolters Kluwer. doi: 10.1016/j.jamcollsurg.2005.11.021.
Reynolds, A., Rubin, J., Clermont, G., Day, J., Vodovotz, Y., & Bard Ermentrout, G. (2006). A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation. J Theor Biol, 242(1), 220-236.Elsevier. doi: 10.1016/j.jtbi.2006.02.016.
Scott, M., Kalinski, P., & Vodovotz, Y. (2006). Insights from the creation of a conceptual model of natural killer and NKT cell responses during acute inflammation. Journal of Critical Care, 21(4), 351-352.Elsevier. doi: 10.1016/j.jcrc.2006.10.015.
Torres, A., Polanco, P., Hyung, K.K., Pinsky, M.R., Bartels, J., Zenker, S., Clermont, G., Puyana, J., Bentley, T.B., & Vodovotz, Y. (2006). PCO2 as surrogate for mathematically-modeled tissue dysfunction/damage during a nonlethal hemorrhagic shock model in mice. Journal of Critical Care, 21(4), 352-353.Elsevier. doi: 10.1016/j.jcrc.2006.10.017.
Vodovotz, Y. (2006). Deciphering the complexity of acute inflammation using mathematical models. Immunol Res, 36(1-3), 237-245.Springer Nature. doi: 10.1385/IR:36:1:237.
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Wang, Y., Kim, P.K.M., Peng, X., Loughran, P., Vodovotz, Y., Zhang, B., & Billiar, T.R. (2006). Cyclic AMP and cyclic GMP suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation via a protein kinase A-dependent pathway. Apoptosis, 11(3), 441-451.Springer Nature. doi: 10.1007/s10495-005-4293-6.
Alvarez, V.V., Wolters, C.L., Vodovotz, Y., & Ji, T. (2005). Physical properties of ice cream containing milk protein concentrates (vol 88, pg 862, 2005). JOURNAL OF DAIRY SCIENCE, 88(6), 2287.
Bartels, J., Baratt, A., Constantine, G., Vodovotz, Y., & Clermont, G. (2005). Identifying candidate model clouds in large parameter spaces. Journal of Critical Care, 20(4), 383-384.Elsevier. doi: 10.1016/j.jcrc.2005.09.020.
Chang, S., Busche, F., Rollins, J., Baratt, A., Vodovotz, Y., & Clermont, G. (2005). Using a mathematical model to predict and test adverse drug response in septic patients. Journal of Critical Care, 20(4), 385.Elsevier. doi: 10.1016/j.jcrc.2005.09.024.
Chow, C.C., Clermont, G., Kumar, R., Lagoa, C., Tawadrous, Z., Gallo, D., Betten, B., Bartels, J., Constantine, G., Fink, M.P., Billiar, T.R., & Vodovotz, Y. (2005). The acute inflammatory response in diverse shock states. Shock, 24(1), 74-84.Wolters Kluwer. doi: 10.1097/01.shk.0000168526.97716.f3.
Clermont, G., Chang, S., Baratt, A., Bartels, J., & Vodovotz, Y. (2005). Toward a model-driven design of clinical trials and individualized therapies. Journal of Critical Care, 20(4), 386.Elsevier. doi: 10.1016/j.jcrc.2005.09.026.
Day, J., Rubin, J., Vodovotz, Y., Chow, C.C., & Clermont, C. (2005). Capturing scenarios of repeated endotoxin administrations in a small mathematical model of the acute inflammatory response and mathematically exploring the nature of tolerance. Journal of Critical Care, 20(4), 391-392.Elsevier. doi: 10.1016/j.jcrc.2005.09.042.
Kim, P.K.M., Vallabhaneni, R., Zuckerbraun, B.S., McCloskey, C., Vodovotz, Y., & Billiar, T.R. (2005). Hypoxia renders hepatocytes susceptible to cell death by nitric oxide. CELLULAR AND MOLECULAR BIOLOGY, 51(3), 229-335.
Kim, P.K.M., Vallabhaneni, R., Zuckerbraun, B.S., McCloskey, C., Vodovotz, Y., & Billiar, T.R. (2005). Hypoxia renders hepatocytes susceptible to cell death by nitric oxide. Cell Mol Biol (Noisy-le-grand), 51(3), 329-335.
Lagoa, C.E., Chow, C., Bartels, J., Barrat, A., Kumar, R., Day, J., Rubin, J., Constantine, G., Chang, S., Fink, M.P., Billiar, T.R., Clermont, G., & Vodovotz, Y. (2005). Mathematical models predict the course of the inflammatory response in rats subjected to trauma-hemorrhagic shock and to anti–tumor necrosis factor α therapy in endotoxemia. Journal of Critical Care, 20(4), 393-394.Elsevier. doi: 10.1016/j.jcrc.2005.09.046.
Lagoa, C.E., Vodovotz, Y., Stolz, D.B., Lhuillier, F., McCloskey, C., Gallo, D., Yang, R., Ustinova, E., Fink, M.P., Billiar, T.R., & Mars, W.M. (2005). The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock. Hepatology, 42(2), 390-399.Wolters Kluwer. doi: 10.1002/hep.20797.
Li, N.Y.K., Verdolini, K., Clermont, G., Mi, Q., Hebda, P.A., & Vodovotz, Y. (2005). An agent-based model of acute phonotrauma. Journal of Critical Care, 20(4), 393-394.Elsevier. doi: 10.1016/j.jcrc.2005.09.047.
Loughran, P.A., Stolz, D.B., Vodovotz, Y., Watkins, S.C., Simmons, R.L., & Billiar, T.R. (2005). Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes. Proc Natl Acad Sci U S A, 102(39), 13837-13842.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0503926102.
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Scott, M.J., Liu, S., Su, G.L., Vodovotz, Y., & Billiar, T.R. (2005). Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions. Shock, 23(5), 453-458.Wolters Kluwer. doi: 10.1097/01.shk.0000160939.08385.f1.
Torres, A., Polanco, P., Hyung, K.K., Clermont, G., Pisnky, M.R., Vodovotz, Y., & Puyana, J.C. (2005). Modeling damage in irreversible hemorrhagic shock. Journal of Critical Care, 20(4), 395-396.Elsevier. doi: 10.1016/j.jcrc.2005.09.050.
Vodovotz, Y., Billiar, T.R., Lagoa, C., Bartels, J., Baratt, A., Rubin, J., Fink, M.P., & Clermont, G. (2005). Central role of danger signals in sepsis, trauma, and hemorrhage: insights from mathematical simulations. Journal of Critical Care, 20(4), 390.Elsevier. doi: 10.1016/j.jcrc.2005.09.038.
Whitcomb, D.C., Aoun, E., Vodovotz, Y., Clermont, G., & Barmada, M.M. (2005). Evaluating disorders with a complex genetics basis. the future roles of meta-analysis and systems biology. Dig Dis Sci, 50(12), 2195-2202.Springer Nature. doi: 10.1007/s10620-005-3033-7.
Zamora, R., & Vodovotz, Y. (2005). Transforming growth factor-β in critical illness. CRITICAL CARE MEDICINE, 33(12), S478-S481.Ovid Technologies (Wolters Kluwer Health). doi: 10.1097/01.CCM.0000191725.59611.14.
Zamora, R., & Vodovotz, Y. (2005). Transforming growth factor-beta in critical illness. Crit Care Med, 33(12 Suppl), S478-S481.Wolters Kluwer. doi: 10.1097/01.ccm.0000191725.59611.14.
Zamora, R., Vodovotz, Y., Betten, B., Wong, C., Zuckerbraun, B., Gibson, K.F., & Ford, H.R. (2005). Intestinal and hepatic expression of BNIP3 in necrotizing enterocolitis: regulation by nitric oxide and peroxynitrite. Am J Physiol Gastrointest Liver Physiol, 289(5), G822-G830.American Physiological Society. doi: 10.1152/ajpgi.00181.2005.
Zamora, R., Vodovotz, Y., Ford, H.R., & Upperman, J.S. (2005). Plasma cytokine levels in experimental necrotizing enterocolitis: a mathematical model is needed. Journal of Critical Care, 20(4), 397.Elsevier. doi: 10.1016/j.jcrc.2005.09.053.
Zhang, Y.C., Lee, J.H., Vodovotz, Y., & Schwartz, S.J. (2005). Changes in distribution of isoflavones and β-glucosidase activity during soy bread proofing and baking (vol 81, pg 741, 2004). CEREAL CHEMISTRY, 82(1), 111.
Clermont, G., Bartels, J., Kumar, R., Constantine, G., Vodovotz, Y., & Chow, C. (2004). In silico design of clinical trials: a method coming of age. Crit Care Med, 32(10), 2061-2070.Wolters Kluwer. doi: 10.1097/01.ccm.0000142394.28791.c3.
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Clermont, G., Kellum, J., Bartels, J., Chang, S., Chow, C., & Vodovotz, Y. (2004). Does the use of a cytokine 'filter' during cardiopulmonary bypass make sense?. Critical Care, 8(Suppl 1), p149.Springer Nature. doi: 10.1186/cc2616.
Clermont, G., Kumar, R., Bartels, J., Vodovotz, Y., Chang, S., & Chow, C. (2004). Predicting the response to therapy from a mathematical model. Critical Care, 8(Suppl 1), p206.Springer Nature. doi: 10.1186/cc2673.
Cook, T., Wang, Z., Alber, S., Liu, K., Watkins, S.C., Vodovotz, Y., Billiar, T.R., & Blumberg, D. (2004). Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53. Cancer Res, 64(21), 8015-8021.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-04-2212.
Kim, P.K.M., Zuckerbraun, B.S., Otterbein, L.E., Vodovotz, Y., & Billiar, T.R. (2004). 'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity. Biol Chem, 385(1), 11-15.De Gruyter. doi: 10.1515/BC.2004.002.
Kumar, R., Clermont, G., Vodovotz, Y., & Chow, C. (2004). Dynamics of Acute Inflammation. In arXiv. doi: 10.48550/arxiv.q-bio/0404034.
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Lagoa, C., Vodovotz, Y., Lhuillier, F., McCloskey, C., Yang, R.K., Fink, M., Stolz, D., Mars, W., & Billiar, T.R. (2004). Plasminogen activator inhibitor-1 (PAI-1) contributes to hepatic injury during hemorrhagic shock. SHOCK, 21, (p. 45).Wolters Kluwer. doi: 10.1097/00024382-200406002-00133.
Mars, W.M., Lagoa, C., Stolz, D.B., Ustinova, E.E., Vodovotz, Y., & Billiar, T.R. (2004). Loss of PAI-1 ameliorates liver damage in hemorrhagic shock. FASEB JOURNAL, 18, (p. A951).
Vodovotz, Y., Clermont, G., Chow, C., & An, G. (2004). Mathematical models of the acute inflammatory response. Curr Opin Crit Care, 10(5), 383-390.Wolters Kluwer. doi: 10.1097/01.ccx.0000139360.30327.69.
Vodovotz, Y., Kim, P.K.M., Bagci, E.Z., Ermentrout, G.B., Chow, C.C., Bahar, I., & Billiar, T.R. (2004). Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies. Curr Mol Med, 4(7), 753-762.Bentham Science Publishers. doi: 10.2174/1566524043359944.
Vodovotz, Y., Zamora, R., Lieber, M.J., & Luckhart, S. (2004). Cross-talk between nitric oxide and transforming growth factor-beta1 in malaria. Curr Mol Med, 4(7), 787-797.Bentham Science Publishers. doi: 10.2174/1566524043359999.
Wang, Z., Cook, T., Alber, S., Liu, K., Kovesdi, I., Watkins, S.K., Vodovotz, Y., Billiar, T.R., & Blumberg, D. (2004). Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity. Cancer Res, 64(4), 1386-1395.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.can-03-1307.
Chung, P., Cook, T., Liu, K., Vodovotz, Y., Zamora, R., Finkelstein, S., Billiar, T., & Blumberg, D. (2003). Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism. Nitric Oxide, 8(2), 119-126.Elsevier. doi: 10.1016/s1089-8603(02)00147-7.
Collins, J.L., Vodovotz, Y., Hierholzer, C., Villavicencio, R.T., Liu, S., Alber, S., Gallo, D., Stolz, D.B., Watkins, S.C., Godfrey, A., Gooding, W., Kelly, E., Peitzman, A.B., & Billiar, T.R. (2003). Characterization of the expression of inducible nitric oxide synthase in rat and human liver during hemorrhagic shock. Shock, 19(2), 117-122.Wolters Kluwer. doi: 10.1097/00024382-200302000-00005.
Collins, J.L., Vodovotz, Y., Hierholzer, C., Villavicencio, R.T., Liu, S.B., Alber, S., Gallo, D., Stolz, D.B., Watkins, S.C., Godfrey, A., Gooding, W., Kelly, E., Peitzman, A.B., & Billiar, T.R. (2003). Characterization of the expression of inducible nitric oxide synthase in rat and human liver during hemorrhagic shock. SHOCK, 19(2), 117-122. doi: 10.1097/00024382-200302000-00005.
Gage, F.A., & Vodovotz, Y. (2003). Normalization of nitric oxide flux improves physiological parameters of porcine kidneys maintained on pulsatile perfusion. Nitric Oxide, 9(3), 141-147.Elsevier. doi: 10.1016/j.niox.2003.10.001.
Lagoa, C., Lhuillier, F., McCloskey, C., Vodovotz, Y., Mars, W., Yang, R., Fink, M., & Billiar, T.R. (2003). PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) IS REGULATED BY iNOS DURING HEMORRHAGIC SHOCK AND IS INVOLVED IN PRO-INFLAMMATORY SIGNALING AND TISSUE INJURY. Shock, 19(Supplement), 51.Wolters Kluwer. doi: 10.1097/00024382-200306001-00150.
Luckhart, S., Crampton, A.L., Zamora, R., Lieber, M.J., Dos Santos, P.C., Peterson, T.M.L., Emmith, N., Lim, J., Wink, D.A., & Vodovotz, Y. (2003). Mammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity. Infect Immun, 71(6), 3000-3009.American Society for Microbiology. doi: 10.1128/IAI.71.6.3000-3009.2003.
Mahidhara, R.S., Hoffman, R.A., Huang, S., Wolf-Johnston, A., Vodovotz, Y., Simmons, R.L., & Billiar, T.R. (2003). Nitric oxide-mediated inhibition of caspase-dependent T lymphocyte proliferation. J Leukoc Biol, 74(3), 403-411.Oxford University Press (OUP). doi: 10.1189/jlb.0602293.
McCloskey, C.A., Zuckerbraun, B.S., Gallo, D.J., Vodovotz, Y., & Billiar, T.R. (2003). A role for angiotensin II in the activation of extracellular signal-regulated kinases in the liver during hemorrhagic shock. Shock, 20(4), 316-319.Wolters Kluwer. doi: 10.1097/01.shk.0000084341.58020.c5.
Vodovotz, Y., Lagoa, C., Kumar, R., Chow, C., & Clermont, G. (2003). MATHEMATICAL SIMULATION OF POST-HEMORRHAGE ENDOTOXEMIA: TIMING IS CRITICAL FOR SURVIVAL. Shock, 19(Supplement), 42.Wolters Kluwer. doi: 10.1097/00024382-200306001-00124.
Weller, R., Schwentker, A., Billiar, T.R., & Vodovotz, Y. (2003). Autologous nitric oxide protects mouse and human keratinocytes from ultraviolet B radiation-induced apoptosis. Am J Physiol Cell Physiol, 284(5), C1140-C1148.American Physiological Society. doi: 10.1152/ajpcell.00462.2002.
Weller, R., Schwentker, A., Billiar, T.R., & Vodovotz, Y. (2003). Autologous nitric oxide protects mouse and human keratinocytes from ultraviolet B radiation-induced apoptosis. American Journal of Physiology - Cell Physiology, 284(5 53-5). doi: 10.1152/ajpcell.00462.2002.
Wilgus, T.A., Vodovotz, Y., Vittadini, E., Clubbs, E.A., & Oberyszyn, T.M. (2003). Reduction of scar formation in full-thickness wounds with topical celecoxib treatment. Wound Repair Regen, 11(1), 25-34.Wiley. doi: 10.1046/j.1524-475x.2003.11106.x.
Apple, M., Waksman, R., Chan, R.C., Vodovotz, Y., Fournadjiev, J., & Bass, B.G. (2002). Radioactive 133-Xenon gas-filled balloon to prevent restenosis: dosimetry, efficacy, and safety considerations. Circulation, 106(6), 725-729.Wolters Kluwer. doi: 10.1161/01.cir.0000023945.21317.27.
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Stolz, D.B., Zamora, R., Vodovotz, Y., Loughran, P.A., Billiar, T.R., Kim, Y.M., Simmons, R.L., & Watkins, S.C. (2002). Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Hepatology, 36(1), 81-93.Wolters Kluwer. doi: 10.1053/jhep.2002.33716.
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Wink, D.A., Cook, J.A., Christodoulou, D., Krishna, M.C., Pacelli, R., Kim, S., DeGraff, W., Gamson, J., Vodovotz, Y., Russo, A., & Mitchell, J.B. (1997). Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin. Nitric Oxide, 1(1), 88-94.Elsevier. doi: 10.1006/niox.1996.0108.
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