headshot of Peter Wipf

Peter Wipf

Distinguished University Professor
pwipf@pitt.edu
(412) 624-8606
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overview

Peter Wipf is the Distinguished University Professor of Chemistry, Professor of Pharmaceutical Sciences, and Professor of Bioengineering at the University of Pittsburgh. He also serves as Director of the Combinatorial Chemistry Center (CCC) and the Center for Chemical Methodologies and Library Development (UPCMLD). His group is involved in many collaborative projects in Chemical Biology, including the Center for Protein Conformational Diseases, the Center for Medical Countermeasures Against Radiation (CMCR) and the University of Pittsburgh Center for Chemical Diversity (UPCDC). He has served on the organizing committee of several conferences and workshops, including the NSF/Organic Syntheses Workshop on Organic Synthesis. He is a member of several editorial boards, including Medicinal Chemistry Letters (ACS MCL), Organic Syntheses, and Organic Reactions (OR).

Prof. Wipf received a Ph.D. in 1987 from the University of Zürich under the guidance of Prof. Heinz Heimgartner. After 2 years as a Swiss NSF postdoctoral fellow with Prof. Robert E. Ireland at the University of Virginia, he joined the University of Pittsburgh, and was promoted to Distinguished Professor in 2004. Prof. Wipf received the NSF Presidential Faculty Fellowship in 1994, the Arthur C. Cope Scholar Award in 1998, the Ernest Guenther Award in the Chemistry of Natural Products in 2009, and the Humboldt Research Award in 2014. He is a Fellow of the AAAS (2002), the RSC (2004), and the ACS (2010). He also serves as an associate editor for ACS Med. Chem. Lett.

about

PhD, University of Zürich, 1987

Borgini, M., Wieteska, L., Hinck, C.S., Krzysiak, T., Hinck, A.P., & Wipf, P. (2023). Synthesis of 13C-methyl-labeled amino acids and their incorporation into proteins in mammalian cells. ORGANIC & BIOMOLECULAR CHEMISTRY, 21(46), 9216-9229.Royal Society of Chemistry (RSC). doi: 10.1039/d3ob01320k.

Pazur, E.J., Tasker, N.R., & Wipf, P. (2023). C3-Functionalization of indoles with α-heteroaryl-substituted methyl alcohols. ORGANIC & BIOMOLECULAR CHEMISTRY, 21(43), 8651-8657.Royal Society of Chemistry (RSC). doi: 10.1039/d3ob01432k.

Chen, P.P., Wipf, P., & Houk, K.N. (2022). How mono- and diphosphine ligands alter regioselectivity of the Rh-catalyzed annulative cleavage of bicyclo[1.1.0]butanes. NATURE COMMUNICATIONS, 13(1), 7292.Springer Nature. doi: 10.1038/s41467-022-34837-x.

Ueda, H., Wipf, P., & Nakamura, H. (2022). Synthesis of sp3-rich chiral bicyclo[3.3.1]nonanes for chemical space expansion and study of biological activities. BIOORGANIC & MEDICINAL CHEMISTRY, 54, 116561.Elsevier. doi: 10.1016/j.bmc.2021.116561.

Borgini, M., Mondal, P., Liu, R., & Wipf, P. (2021). Chemical modulation of Kv7 potassium channels. RSC MEDICINAL CHEMISTRY, 12(4), 483-537.Royal Society of Chemistry (RSC). doi: 10.1039/d0md00328j.

Rastelli, E.J., Sannino, S., Hart, D.J., Sharlow, E.R., Lazo, J.S., Brodsky, J.L., & Wipf, P. (2021). Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 46, 128167.Elsevier. doi: 10.1016/j.bmcl.2021.128167.

Tasker, N.R., & Wipf, P. (2021). Biosynthesis, total synthesis, and biological profiles of Ergot alkaloids. In The Alkaloids: Chemistry and Biology. 85, (pp. 1-112).Elsevier. doi: 10.1016/bs.alkal.2020.08.001.

Yang, Z., Wang, D., Johnson, J.K., Pascal, L.E., Takubo, K., Avula, R., Chakka, A.B., Zhou, J., Chen, W., Zhong, M., Song, Q., Ding, H., Wu, Z., Chandran, U.R., Maskrey, T.S., Nelson, J.B., Wipf, P., & Wang, Z. (2020). A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer. MOLECULAR CANCER THERAPEUTICS, 19(1), 75-88.American Association for Cancer Research (AACR). doi: 10.1158/1535-7163.MCT-19-0489.

Cheikhi, A., Wallace, C., St Croix, C., Cohen, C., Tang, W.Y., Wipf, P., Benos, P.V., Ambrosio, F., & Barchowsky, A. (2019). Mitochondria are a substrate of cellular memory. FREE RADICAL BIOLOGY AND MEDICINE, 130, 528-541.Elsevier. doi: 10.1016/j.freeradbiomed.2018.11.028.

Tasker, N.R., Rastelli, E.J., Blanco, I.K., Burnett, J.C., Sharlow, E.R., Lazo, J.S., & Wipf, P. (2019). In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors. ORGANIC & BIOMOLECULAR CHEMISTRY, 17(9), 2448-2466.Royal Society of Chemistry (RSC). doi: 10.1039/c9ob00025a.

Tasker, N.R., Rastelli, E.J., Burnett, J.C., Sharlow, E.R., Lazo, J.S., & Wipf, P. (2019). Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 29(16), 2008-2015.Elsevier. doi: 10.1016/j.bmcl.2019.06.048.

Saydmohammed, M., Vollmer, L.L., Onuoha, E.O., Maskrey, T.S., Gibson, G., Watkins, S.C., Wipf, P., Vogt, A., & Tsang, M. (2018). A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development. MOLECULES, 23(7), 1691.MDPI. doi: 10.3390/molecules23071691.

Jang, S., Lewis, T.S., Powers, C., Khuchua, Z., Baines, C.P., Wipf, P., & Javadov, S. (2017). Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion. ANTIOXIDANTS & REDOX SIGNALING, 27(1), 57-69.Mary Ann Liebert. doi: 10.1089/ars.2016.6635.

Xu, J., & Wipf, P. (2017). Indole synthesis by palladium-catalyzed tandem allylic isomerization - furan Diels-Alder reaction. ORGANIC & BIOMOLECULAR CHEMISTRY, 15(34), 7093-7096.Royal Society of Chemistry (RSC). doi: 10.1039/c7ob01654a.

Kumar, M., Reed, N., Liu, R., Aizenman, E., Wipf, P., & Tzounopoulos, T. (2016). Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. MOLECULAR PHARMACOLOGY, 89(6), 667-677.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/mol.115.103200.

Salamoun, J.M., McQueeney, K.E., Patil, K., Geib, S.J., Sharlow, E.R., Lazo, J.S., & Wipf, P. (2016). Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor. ORGANIC & BIOMOLECULAR CHEMISTRY, 14(27), 6398-6402.Royal Society of Chemistry (RSC). doi: 10.1039/c6ob00946h.

Greenberger, J., Kagan, V., Bayir, H., Wipf, P., & Epperly, M. (2015). Antioxidant Approaches to Management of Ionizing Irradiation Injury. Antioxidants, 4(1), 82-101.MDPI. doi: 10.3390/antiox4010082.

Ma, J., Lim, C., Sacher, J.R., Van Houten, B., Qian, W., & Wipf, P. (2015). Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4828-4833.Elsevier. doi: 10.1016/j.bmcl.2015.06.073.

Qian, W., Salamoun, J., Wang, J., Roginskaya, V., Van Houten, B., & Wipf, P. (2015). The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(4), 856-863.Elsevier. doi: 10.1016/j.bmcl.2014.12.072.

Rosenker, K.M.G., Paquette, W.D., Johnston, P.A., Sharlow, E.R., Vogt, A., Bakan, A., Lazo, J.S., & Wipf, P. (2015). Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B. BIOORGANIC & MEDICINAL CHEMISTRY, 23(12), 2810-2818.Elsevier. doi: 10.1016/j.bmc.2015.01.043.

Tandon, M., Salamoun, J.M., Carder, E.J., Farber, E., Xu, S., Deng, F., Tang, H., Wipf, P., & Wang, Q.J. (2015). SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest. In Languino, L.R. (Ed.). PLOS ONE, 10(3), e0119346.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0119346.

Adam, C., Baeurle, A., Brodsky, J.L., Wipf, P., Schrama, D., Becker, J.C., & Houben, R. (2014). The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma. In Sherman, M. (Ed.). PLOS ONE, 9(4), e92041.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0092041.

Greenberger, J.S., Berhane, H., Shinde, A., Rhieu, B.H., Bernard, M., Wipf, P., Skoda, E.M., & Epperly, M.W. (2014). Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors. Frontiers in Oncology, 4, 24.Frontiers. doi: 10.3389/fonc.2014.00024.

Neal, M.D., Jia, H., Eyer, B., Good, M., Guerriero, C.J., Sodhi, C.P., Afrazi, A., Prindle, T.J., Ma, C., Branca, M., Ozolek, J., Brodsky, J.L., Wipf, P., & Hackam, D.J. (2013). Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors. In Jeyaseelan, S. (Ed.). PLOS ONE, 8(6), e65779.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0065779.

Cao, L., Maciejewski, J.P., Elzner, S., Amantini, D., & Wipf, P. (2012). Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone. ORGANIC & BIOMOLECULAR CHEMISTRY, 10(30), 5811-5814.Royal Society of Chemistry (RSC). doi: 10.1039/c2ob25353d.

Keffer, J.L., Hammill, J.T., Lloyd, J.R., Plaza, A., Wipf, P., & Bewley, C.A. (2012). Geographic Variability and Anti-Staphylococcal Activity of the Chrysophaentins and Their Synthetic Fragments. MARINE DRUGS, 10(5), 1103-1125.MDPI. doi: 10.3390/md10051103.

Liu, Z., Celotto, A.M., Romero, G., Wipf, P., & Palladino, M.J. (2012). Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis. NEUROBIOLOGY OF DISEASE, 45(1), 362-368.Elsevier. doi: 10.1016/j.nbd.2011.08.022.

Pizzo, C., Faral-Tello, P., Salinas, G., Flo, M., Robello, C., Wipf, P., & Graciela Mahler, S. (2012). Selenosemicarbazones as potent cruzipain inhibitors and their antiparasitic properties against Trypanosoma cruzi. MEDCHEMCOMM, 3(3), 362-368.Royal Society of Chemistry (RSC). doi: 10.1039/c2md00283c.

Seguin, S.P., Ireland, A.W., Gupta, T., Wright, C.M., Miyata, Y., Wipf, P., Pipas, J.M., Gestwicki, J.E., & Brodsky, J.L. (2012). A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. ANTIVIRAL RESEARCH, 96(1), 70-81.Elsevier. doi: 10.1016/j.antiviral.2012.07.012.

Skoda, E.M., Davis, G.C., & Wipf, P. (2012). Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 16(1), 26-34.American Chemical Society (ACS). doi: 10.1021/op2002613.

Tandon, M., Wang, L., Xu, Q., Xie, X., Wipf, P., & Wang, Q.J. (2012). A Targeted Library Screen Reveals a New Inhibitor Scaffold for Protein Kinase D. In Jung, M. (Ed.). PLOS ONE, 7(9), e44653.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0044653.

Wang, L., Ma, C., Wipf, P., & Xie, X.Q. (2012). Linear and Nonlinear Support Vector Machine for the Classification of Human 5-HT1A Ligand Functionality. MOLECULAR INFORMATICS, 31(1), 85-95.Wiley. doi: 10.1002/minf.201100126.

Bernard, M.E., Kim, H., Berhane, H., Epperly, M.W., Franicola, D., Zhang, X., Houghton, F., Shields, D., Wang, H., Bakkenist, C.J., Frantz, M.C., Forbeck, E.M., Goff, J.P., Wipf, P., & Greenberger, J.S. (2011). GS-Nitroxide (JP4-039)-Mediated Radioprotection of Human Fanconi Anemia Cell Lines. RADIATION RESEARCH, 176(5), 603-612.Radiation Research Society. doi: 10.1667/RR2624.1.

Botha, M., Chiang, A.N., Needham, P.G., Stephens, L.L., Hoppe, H.C., Kuelzer, S., Przyborski, J.M., Lingelbach, K., Wipf, P., Brodsky, J.L., Shonhai, A., & Blatch, G.L. (2011). Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock. CELL STRESS & CHAPERONES, 16(4), 389-401.Elsevier. doi: 10.1007/s12192-010-0250-6.

Braunstein, M.J., Scott, S.S., Scott, C.M., Behrman, S., Walter, P., Wipf, P., Coplan, J.D., Chrico, W., Joseph, D., Brodsky, J.L., & Batuman, O. (2011). Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3‐101. Journal of Oncology, 2011(1), 232037.Hindawi. doi: 10.1155/2011/232037.

Bravo-Altamirano, K., George, K.M., Frantz, M.C., LaValle, C.R., Tandon, M., Leimgruber, S., Sharlow, E.R., Lazo, J.S., Wang, Q.J., & Wipf, P. (2011). Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D. ACS MEDICINAL CHEMISTRY LETTERS, 2(2), 154-159.American Chemical Society (ACS). doi: 10.1021/ml100230n.

Frantz, M.C., Pierce, J.G., Pierce, J.M., Li, K., Wan, Q., Johnson, M., & Wipf, P. (2011). Large-Scale Asymmetric Synthesis of the Bioprotective Agent JP4-039 and Analogs. ORGANIC LETTERS, 13(9), 2318-2321.American Chemical Society (ACS). doi: 10.1021/ol200567p.

Gehret, J.J., Gu, L., Gerwick, W.H., Wipf, P., Sherman, D.H., & Smith, J.L. (2011). Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis STRUCTURE OF A DECARBOXYLATING THIOESTERASE. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(16), 14445-14454.Elsevier. doi: 10.1074/jbc.M110.214635.

George, K.M., Frantz, M.C., Bravo-Altamirano, K., LaValle, C.R., Tandon, M., Leimgruber, S., Sharlow, E.R., Lazo, J.S., Wang, Q.J., & Wipf, P. (2011). Design, Synthesis, and Biological Evaluation of PKD Inhibitors. Pharmaceutics, 3(2), 186-228.MDPI. doi: 10.3390/pharmaceutics3020186.

Goff, J.P., Epperly, M.W., Dixon, T., Wang, H., Franicola, D., Shields, D., Wipf, P., Li, S., Gao, X., & Greenberger, J.S. (2011). Radiobiologic Effects of GS-Nitroxide (JP4-039) on the Hematopoietic Syndrome. IN VIVO, 25(3), 315-323.International Institute of Anticancer Research.

Hopkins, C.D., Schmitz, J.C., Chu, E., & Wipr, P. (2011). Total Synthesis of (-)-CP2-Disorazole C1. ORGANIC LETTERS, 13(15), 4088-4091.American Chemical Society (ACS). doi: 10.1021/ol2015994.

Hoye, A.T., & Wipf, P. (2011). Total Synthesis of (-)-Sessilifoliamide C and (-)-8-epi-Stemoamide. ORGANIC LETTERS, 13(10), 2634-2637.American Chemical Society (ACS). doi: 10.1021/ol200743u.

Huryn, D.M., Brodsky, J.L., Brummond, K.M., Chambers, P.G., Eyer, B., Ireland, A.W., Kawasumi, M., LaPorte, M.G., Lloyd, K., Manteau, B., Nghiem, P., Quade, B., Seguin, S.P., & Wipf, P. (2011). Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(17), 6757-6762.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1015251108.

Kim, H., Bernard, M.E., Epperly, M.W., Shen, H., Amoscato, A., Dixon, T.M., Doemling, A.S., Li, S., Gao, X., Wipf, P., Wang, H., Zhang, X., Kagan, V.E., & Greenberger, J.S. (2011). Amelioration of Radiation Esophagitis by Orally Administered p53/Mdm2/Mdm4 Inhibitor (BEB55) or GS-Nitroxide. IN VIVO, 25(6), 841-848.International Institute of AntiCancer Research.

Milner, E., Gardner, S., Moon, J., Grauer, K., Auschwitz, J., Bathurst, I., Caridha, D., Gerena, L., Gettayacamin, M., Johnson, J., Kozar, M., Lee, P., Leed, S., Li, Q., McCalmont, W., Melendez, V., Roncal, N., Sciotti, R., Smith, B., Sousa, J., Tungtaeng, A., Wipf, P., & Dow, G. (2011). Structure-Activity Relationships of 4-Position Diamine Quinoline Methanols as Intermittent Preventative Treatment (IPT) against Plasmodium falciparum. JOURNAL OF MEDICINAL CHEMISTRY, 54(18), 6277-6285.American Chemical Society (ACS). doi: 10.1021/jm200647u.

Pizzo, C., Saiz, C., Talevi, A., Gavernet, L., Palestro, P., Bellera, C., Bruno Blanch, L., Benitez, D., Cazzulo, J.J., Chidichimo, A., Wipf, P., & Mahler, S.G. (2011). Synthesis of 2-Hydrazolyl-4-Thiazolidinones Based on Multicomponent Reactions and Biological Evaluation Against Trypanosoma Cruzi. CHEMICAL BIOLOGY & DRUG DESIGN, 77(3), 166-172.Wiley. doi: 10.1111/j.1747-0285.2010.01071.x.

Rwigema, J.C.M., Beck, B., Wang, W., Doemling, A., Epperly, M.W., Shields, D., Goff, J.P., Franicola, D., Dixon, T., Frantz, M.C., Wipf, P., Tyurina, Y., Kagan, V.E., Wang, H., & Greenberger, J.S. (2011). TWO STRATEGIES FOR THE DEVELOPMENT OF MITOCHONDRION-TARGETED SMALL MOLECULE RADIATION DAMAGE MITIGATORS. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 80(3), 860-868.Elsevier. doi: 10.1016/j.ijrobp.2011.01.059.

Saiz, C., Wipf, P., & Mahlerf, G. (2011). Synthesis and Ring-Chain-Ring Tautomerism of Bisoxazolidines, Thiazolidinyloxazolidines, and Spirothiazolidines. JOURNAL OF ORGANIC CHEMISTRY, 76(14), 5738-5746.American Chemical Society (ACS). doi: 10.1021/jo2008498.

Sharlow, E.R., Wilson, G.M., Close, D., Leimgruber, S., Tandon, M., Reed, R.B., Shun, T.Y., Wang, Q.J., Wipf, P., & Lazo, J.S. (2011). Discovery of Diverse Small Molecule Chemotypes with Cell-Based PKD1 Inhibitory Activity. In Bogyo, M. (Ed.). PLOS ONE, 6(10), e25134.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0025134.

Wang, L., Xie, Z., Wipf, P., & Xie, X.Q. (2011). Residue Preference Mapping of Ligand Fragments in the Protein Data Bank. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 51(4), 807-815.American Chemical Society (ACS). doi: 10.1021/ci100386y.

Wipf, P., & Manojlovic, M.D. (2011). Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 7(1), 824-830.Beilstein Institut. doi: 10.3762/bjoc.7.94.

Zaware, N., LaPorte, M.G., Farid, R., Liu, L., Wipf, P., & Floreancig, P.E. (2011). Diversity-Oriented Synthesis of a Library of Substituted Tetrahydropyrones Using Oxidative Carbon-Hydrogen Bond Activation and Click Chemistry. MOLECULES, 16(5), 3648-3662.MDPI. doi: 10.3390/molecules16053648.

Epperly, M.W., Franicola, D., Shields, D., Rwigema, J.C., Stone, B., Zhang, X., Mcbride, W., Georges, G., Wipf, P., & Greenberger, J.S. (2010). Screening of Antimicrobial Agents for In Vitro Radiation Protection and Mitigation Capacity, Including those Used in Supportive Care Regimens for Bone Marrow Transplant Recipients. IN VIVO, 24(1), 9-19.The International Institute of Anticancer Research.

Epperly, M.W., Goff, J.P., Li, S., Gao, X., Wipf, P., Dixon, T., Wang, H., Franicola, D., Shen, H., Rwigema, J.C.M., Kagan, V., Bernard, M., & Greenberger, J.S. (2010). Intraesophageal Administration of GS-Nitroxide (JP4-039) Protects Against Ionizing Irradiation-induced Esophagitis. IN VIVO, 24(6), 811-819.International Institute of Anticancer Research.

Gokhale, A., Rwigema, J.C., Epperly, M.W., Glowacki, J., Wang, H., Wipf, P., Goff, J.P., Dixon, T., Patrene, K., & Greenberger, J.S. (2010). Small Molecule GS-Nitroxide Ameliorates Ionizing Irradiation-Induced Delay in Bone Wound Healing in a Novel Murine Model. IN VIVO, 24(4), 377-385.International Institute of AntiCancer Research.

Hammill, J.T., Contreras-Garcia, J., Virshup, A.M., Beratan, D.N., Yang, W., & Wipf, P. (2010). Synthesis and chemical diversity analysis of bicyclo[3.3.1]non-3-en-2-ones. TETRAHEDRON, 66(31), 5852-5862.Elsevier. doi: 10.1016/j.tet.2010.04.112.

LaValle, C.R., Bravo-Altamirano, K., Giridhar, K., Chen, J., Sharlow, E.R., Lazo, J.S., Wipf, P., & Wang, Q.J. (2010). Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility. FASEB JOURNAL, 24(1), 5.Springer Nature. doi: 10.1186/1472-6769-10-5.

LaValle, C.R., George, K.M., Sharlow, E.R., Lazo, J.S., Wipf, P., & Wang, Q.J. (2010). Protein kinase D as a potential new target for cancer therapy. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1806(2), 183-192.Elsevier. doi: 10.1016/j.bbcan.2010.05.003.

Lazo, J.S., Reese, C.E., Vogt, A., Vollmer, L.L., Kitchens, C.A., Guenther, E., Graham, T.H., Hopkins, C.D., & Wipf, P. (2010). Identifying a Resistance Determinant for the Antimitotic Natural Products Disorazole C1 and A1. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 332(3), 906-911.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/jpet.109.162842.

Milner, E., McCalmont, W., Bhonsle, J., Caridha, D., Cobar, J., Gardner, S., Gerena, L., Goodine, D., Lanteri, C., Melendez, V., Roncal, N., Sousa, J., Wipf, P., & Dow, G.S. (2010). Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols. MALARIA JOURNAL, 9(1), 51.Springer Nature. doi: 10.1186/1475-2875-9-51.

Mishra, J.K., Wipf, P., & Sinha, S.C. (2010). Studies toward a Library of Tetrahydrofurans: Click and MCR Products of Mono- And Bis-Tetrahydrofurans. JOURNAL OF COMBINATORIAL CHEMISTRY, 12(5), 609-612.American Chemical Society (ACS). doi: 10.1021/cc1000709.

Mo, T., Mi, X., Milner, E.E., Dow, G.S., & Wipf, P. (2010). Synthesis of an 8-pentafluorosulfanyl analog of the antimalarial agent mefloquine. TETRAHEDRON LETTERS, 51(39), 5137-5140.Elsevier. doi: 10.1016/j.tetlet.2010.07.113.

Tyurina, Y.Y., Tyurin, V.A., Kaynar, A.M., Kapralova, V.I., Wasserloos, K., Li, J., Mosher, M., Wright, L., Wipf, P., Watkins, S., Pitt, B.R., & Kagan, V.E. (2010). Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 299(1), L73-L85.American Physiological Society. doi: 10.1152/ajplung.00035.2010.

Wang, X.J., Zhang, L., Krishnamurthy, D., Senanayake, C.H., & Wipf, P. (2010). General Solution to the Synthesis of N-2-Substituted 1,2,3-Triazoles. ORGANIC LETTERS, 12(20), 4632-4635.American Chemical Society (ACS). doi: 10.1021/ol101965a.

Wipf, P., & George, K.M. (2010). Regioselective Palladium-Catalyzed Cross-Coupling Reactions of 2,4,7-Trichloroquinazoline. SYNLETT, 2010(4), 644-648.Thieme. doi: 10.1055/s-0029-1219391.

Wisen, S., Bertelsen, E.B., Thompson, A.D., Patury, S., Ung, P., Chang, L., Evans, C.G., Walter, G.M., Wipf, P., Carlson, H.A., Brodsky, J.L., Zuiderweg, E.R.P., & Gestwicki, J.E. (2010). Binding of a Small Molecule at a Protein-Protein Interface Regulates the Chaperone Activity of Hsp70-Hsp40. ACS CHEMICAL BIOLOGY, 5(6), 611-622.American Chemical Society (ACS). doi: 10.1021/cb1000422.

Xu, F.L., Rbaibi, Y., Kiselyov, K., Lazo, J.S., Wipf, P., & Saunders, W.S. (2010). Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1. BMC Molecular and Cell Biology, 10(1), 1.Springer Nature. doi: 10.1186/1472-6769-10-1.

Zuniga, J.E., Hammill, J.T., Drory, O., Nuss, J.E., Burnett, J.C., Gussio, R., Wipf, P., Bavari, S., & Brunger, A.T. (2010). Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A. In Andreu, A.L. (Ed.). PLOS ONE, 5(6), e11378.Public Library of Science (PLoS). doi: 10.1371/journal.pone.0011378.

Banerjee, A., Sergienko, E., Vasile, S., Gupta, V., Vuori, K., & Wipf, P. (2009). Triple Hybrids of Steroids, Spiroketals, and Oligopeptides as New Biomolecular Chimeras. ORGANIC LETTERS, 11(1), 65-68.American Chemical Society (ACS). doi: 10.1021/ol802247m.

Burnett, J.C., Wang, C., Nuss, J.E., Nguyen, T.L., Hermone, A.R., Schmidt, J.J., Gussio, R., Wipf, P., & Bavari, S. (2009). Pharmacophore-guided lead optimization: The rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(19), 5811-5813.Elsevier. doi: 10.1016/j.bmcl.2009.01.111.

Chiang, A.N., Valderramos, J.C., Balachandran, R., Chovatiya, R.J., Mead, B.P., Schneider, C., Bell, S.L., Klein, M.G., Huryn, D.M., Chen, X.S., Day, B.W., Fidock, D.A., Wipf, P., & Brodsky, J.L. (2009). Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. BIOORGANIC & MEDICINAL CHEMISTRY, 17(4), 1527-1533.Elsevier. doi: 10.1016/j.bmc.2009.01.024.

Fuller, A.A., Du, D., Liu, F., Davoren, J.E., Bhabha, G., Kroon, G., Case, D.A., Dyson, H.J., Powers, E.T., Wipf, P., Gruebele, M., & Kelly, J.W. (2009). Evaluating β-turn mimics as β-sheet folding nucleators. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(27), 11067-11072.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0813012106.

Gu, L., Wang, B., Kulkarni, A., Geders, T.W., Grindberg, R.V., Gerwick, L., Hakansson, K., Wipf, P., Smith, J.L., Gerwick, W.H., & Sherman, D.H. (2009). Metamorphic enzyme assembly in polyketide diversification. NATURE, 459(7247), 731-735.Springer Nature. doi: 10.1038/nature07870.

Gu, L., Wang, B., Kulkarni, A., Gehret, J.J., Lloyd, K.R., Gerwick, L., Gerwick, W.H., Wipf, P., Hakansson, K., Smith, J.L., & Sherman, D.H. (2009). Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(44), 16033-+.American Chemical Society (ACS). doi: 10.1021/ja9071578.

Hopkins, C.D., & Wipf, P. (2009). Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides. NATURAL PRODUCT REPORTS, 26(5), 585-601.Royal Society of Chemistry (RSC). doi: 10.1039/b813799b.

Ihle, N.T., Lemos, R., Schwartz, D., Oh, J., Halter, R.J., Wipf, P., Kirkpatrick, L., & Powis, G. (2009). Peroxisome proliferator-activated receptor γ agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity. MOLECULAR CANCER THERAPEUTICS, 8(1), 94-100.American Association for Cancer Research (AACR). doi: 10.1158/1535-7163.MCT-08-0714.

Ihle, N.T., Lemos, R.J., Wipf, P., Yacoub, A., Mitchell, C., Siwak, D., Mills, G.B., Dent, P., Kirkpatrick, D.L., & Powis, G. (2009). Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance. CANCER RESEARCH, 69(1), 143-150.American Association for Cancer Research (AACR). doi: 10.1158/0008-5472.CAN-07-6656.

Johnston, P.A., Foster, C.A., Tiemo, M.B., Shun, T.Y., Shinde, S.N., Paquette, W.D., Brummond, K.M., Wipf, P., & Lazo, J.S. (2009). Cdc25B Dual-Specificity Phosphatase Inhibitors Identified in a High-Throughput Screen of the NIH Compound Library. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 7(3), 250-265.Mary Ann Liebert. doi: 10.1089/adt.2008.186.

Kagan, V.E., Bayir, A., Bayir, H., Stoyanovsky, D., Borisenko, G.G., Tyurina, Y.Y., Wipf, P., Atkinson, J., Greenberger, J.S., Chapkin, R.S., & Belikova, N.A. (2009). Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: A new strategy in anti-apoptotic drug discovery. MOLECULAR NUTRITION & FOOD RESEARCH, 53(1), 104-114.Wiley. doi: 10.1002/mnfr.200700402.

Kagan, V.E., Bayir, H.A., Belikova, N.A., Kapralov, O., Tyurina, Y.Y., Tyurin, V.A., Jiang, J., Stoyanovsky, D.A., Wipf, P., Kochanek, P.M., Greenberger, J.S., Pitt, B., Shvedova, A.A., & Borisenko, G. (2009). Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. FREE RADICAL BIOLOGY AND MEDICINE, 46(11), 1439-1453.Elsevier. doi: 10.1016/j.freeradbiomed.2009.03.004.

Kagan, V.E., Wipf, P., Stoyanovsky, D., Greenberger, J.S., Borisenko, G., Belikova, N.A., Yanamala, N., Arias, A.K.S., Tungekar, M.A., Jiang, J., Tyurina, Y.Y., Ji, J., Klein-Seetharaman, J., Pitt, B.R., Shvedova, A.A., & Bayir, H. (2009). Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions. ADVANCED DRUG DELIVERY REVIEWS, 61(14), 1375-1385.Elsevier. doi: 10.1016/j.addr.2009.06.008.

Liang, M., Saiz, C., Pizzo, C., & Wipf, P. (2009). Synthesis of pyrrolo[1,3]diazepines by a dipolar cycloaddition-retro-Mannich domino reaction. TETRAHEDRON LETTERS, 50(49), 6810-6813.Elsevier. doi: 10.1016/j.tetlet.2009.09.107.

Mukhopadhyay, P., Wipf, P., & Beratan, D.N. (2009). Optical Signatures of Molecular Dissymmetry: Combining Theory with Experiments To Address Stereochemical Puzzles. ACCOUNTS OF CHEMICAL RESEARCH, 42(6), 809-819.American Chemical Society (ACS). doi: 10.1021/ar8002859.

Patham, B., Duffy, J., Lane, A., Davis, R.C., Wipf, P., Fewell, S.W., Brodsky, J.L., & Mensa-Wilmot, K. (2009). Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. BIOCHEMICAL JOURNAL, 419(2), 507-517.Portland Press. doi: 10.1042/BJ20081787.

Petronijevic, F., Timmons, C., Cuzzupe, A., & Wipf, P. (2009). A microwave assisted intramolecular-furan-Diels-Alder approach to 4-substituted indoles. CHEMICAL COMMUNICATIONS, 0(1), 104-106.Royal Society of Chemistry (RSC). doi: 10.1039/b816989f.

Rajagopalan, M., Gupta, K., Epperly, M., Franicola, D., Zhang, X., Wang, H., Kagan, V., Wipf, P., & Greenberger, J. (2009). The mitochondrial targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair. CANCER RESEARCH, 69(5), 717-726.International Journal of Experimental and Clinical Pathophysiology and Drug Research.

Saiz, C., Pizzo, C., Manta, E., Wipf, P., & Mahler, S.G. (2009). Microwave-assisted tandem reactions for the synthesis of 2-hydrazolyl-4-thiazolidinones. TETRAHEDRON LETTERS, 50(8), 901-904.Elsevier. doi: 10.1016/j.tetlet.2008.12.020.

Saiz, C., Wipf, P., Manta, E., & Mahler, G. (2009). Reversible Thiazolidine Exchange: A New Reaction Suitable for Dynamic Combinatorial Chemistry. ORGANIC LETTERS, 11(15), 3170-3173.American Chemical Society (ACS). doi: 10.1021/ol901104a.

Sarachine, M.J., Janjic, J.M., Wipf, P., & Day, B.W. (2009). Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor β. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(9), 2404-2408.Elsevier. doi: 10.1016/j.bmcl.2009.03.075.

Sharlow, E.R., Close, D., Shun, T., Leimgruber, S., Reed, R., Mustata, G., Wipf, P., Johnson, J., O'Neil, M., Groegl, M., Magill, A.J., & Lazo, J.S. (2009). Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen. In Ghedin, E. (Ed.). PLOS NEGLECTED TROPICAL DISEASES, 3(11), e540.Public Library of Science (PLoS). doi: 10.1371/journal.pntd.0000540.

Tierno, M.B., Kitchens, C.A., Petrik, B., Graham, T.H., Wipf, P., Xu, F.L., Saunders, W.S., Raccor, B.S., Balachandran, R., Day, B.W., Stout, J.R., Walczak, C.E., Ducruet, A.P., Reese, C.E., & Lazo, J.S. (2009). Microtubule Binding and Disruption and Induction of Premature Senescence by Disorazole C1. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 328(3), 715-722.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/jpet.108.147330.

Walczak, M.A.A., Shin, B.K., Wipf, P., & Saxena, S. (2009). An ESR analysis of the mechanism of pericyclic reactions of bicyclobutane. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(11), 2363-2366.Royal Society of Chemistry (RSC). doi: 10.1039/b815469b.

Werner, S., Nielsen, S.D., Wipf, P., Turner, D.M., Chambers, P.G., Geib, S.J., Curran, D.P., & Zhang, W. (2009). Fluorous, Parallel Synthesis of a Piperazinedione-Fused Tricyclic Compound Library. JOURNAL OF COMBINATORIAL CHEMISTRY, 11(3), 452-459.American Chemical Society (ACS). doi: 10.1021/cc900003q.

Wipf, P., Arnold, D., Carter, K., Dong, S., Johnston, P.A., Sharlow, E., Lazo, J.S., & Huryn, D.H. (2009). A Case Study from the Chemistry Core of the Pittsburgh Molecular Library Screening Center: The Polo-like Kinase Polo-Box Domain (Plk1-PBD). CURRENT TOPICS IN MEDICINAL CHEMISTRY, 9(13), 1194-1205.Bentham Science Publishers. doi: 10.2174/156802609789753590.

Wipf, P., Mo, T., Geib, S.J., Caridha, D., Dow, G.S., Gerena, L., Roncal, N., & Milner, E.E. (2009). Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(20), 4163-4165.Royal Society of Chemistry (RSC). doi: 10.1039/b911483a.

Wipf, P., Xiao, J., & Stephenson, C.R.J. (2009). Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents. CHIMIA, 63(11), 764-775.Swiss Chemical Society. doi: 10.2533/chimia.2009.764.

Wright, C.M., Seguin, S.P., Fewell, S.W., Zhang, H., Ishwad, C., Vats, A., Lingwood, C.A., Wipf, P., Fanning, E., Pipas, J.M., & Brodsky, J.L. (2009). Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. VIRUS RESEARCH, 141(1), 71-80.Elsevier. doi: 10.1016/j.virusres.2008.12.018.

Bakan, A., Lazo, J.S., Wipf, P., Brummond, K.M., & Bahar, I. (2008). Toward a Molecular Understanding of the Interaction of Dual Specificity Phosphatases with Substrates: Insights from Structure-Based Modeling and High Throughput Screening. CURRENT MEDICINAL CHEMISTRY, 15(25), 2536-2544.Bentham Science Publishers Ltd. doi: 10.2174/092986708785909003.

Balachandran, R., Hopkins, T.D., Thomas, C.A., Wipf, P., & Day, B.W. (2008). Tubulin‐Perturbing Naphthoquinone Spiroketals. Chemical Biology & Drug Design, 71(2), 117-124.Wiley. doi: 10.1111/j.1747-0285.2007.00616.x.

Hermone, A.R., Burnett, J.C., Nuss, J.E., Tressler, L.E., Nguyen, T.L., Solaja, B.A., Vennerstrom, J.L., Schmidt, J.J., Wipf, P., Bavari, S., & Gussio, R. (2008). Three-Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three-Zone Pharmacophore. CHEMMEDCHEM, 3(12), 1905-1912.Wiley. doi: 10.1002/cmdc.200800241.

Hoye, A.T., Davoren, J.E., Wipf, P., Fink, M.P., & Kagan, V.E. (2008). Targeting mitochondria. ACCOUNTS OF CHEMICAL RESEARCH, 41(1), 87-97.American Chemical Society (ACS). doi: 10.1021/ar700135m.

Jiang, J., Belikova, N.A., Hoye, A.T., Zhao, Q., Epperly, M.W., Greenberger, J.S., Wipf, P., & Kagan, V.E. (2008). A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 70(3), 816-825.Elsevier. doi: 10.1016/j.ijrobp.2007.10.047.

Johnston, P.A., Soares, K.M., Shinde, S.N., Foster, C.A., Shun, T.Y., Takyi, H.K., Wipf, P., & Lazo, J.S. (2008). Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 6(4), 505-518.Mary Ann Liebert. doi: 10.1089/adt.2008.151.

Keinan, S., Paquette, W.D., Skoko, J.J., Beratan, D.N., Yang, W., Shinde, S., Johnston, P.A., Lazo, J.S., & Wipf, P. (2008). Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. ORGANIC & BIOMOLECULAR CHEMISTRY, 6(18), 3256-3263.Royal Society of Chemistry (RSC). doi: 10.1039/b806712k.

Lazo, J.S., & Wipf, P. (2008). Is Cdc25 a Druggable Target?. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 8(8), 837-842.Bentham Science Publishers. doi: 10.2174/187152008786847738.

Liu, F., Du, D., Fuller, A.A., Davoren, J.E., Wipf, P., Kelly, J.W., & Gruebele, M. (2008). An experimental survey of the transition between two-state and downhill protein folding scenarios. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(7), 2369-2374.Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.0711908105.

Pierce, J.G., Kasi, D., Fushimi, M., Cuzzupe, A., & Wipf, P. (2008). Synthesis of hydroxylated bicyclic amino acids from L-tyrosine:: Octahydro-1H-indole carboxylates. JOURNAL OF ORGANIC CHEMISTRY, 73(19), 7807-7810.American Chemical Society (ACS). doi: 10.1021/jo801552j.

Rabu, C., Wipf, P., Brodsky, J.L., & High, S. (2008). A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(41), 27504-27513.Elsevier. doi: 10.1074/jbc.M804591200.

Sharlow, E.R., Giridhar, K.V., Lavalle, C.R., Chen, J., Leimgruber, S., Barrett, R., Bravo-Altamirano, K., Wipf, P., Lazo, J.S., & Wang, Q.J. (2008). Potent and Selective Disruption of Protein Kinase D Functionality by a Benzoxoloazepinolone. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(48), 33516-33526.Elsevier. doi: 10.1074/jbc.M805358200.

Timmons, C., & Wipf, P. (2008). Density Functional Theory Calculation of 13C NMR Shifts of Diazaphenanthrene Alkaloids: Reinvestigation of the Structure of Samoquasine A. JOURNAL OF ORGANIC CHEMISTRY, 73(22), 9168-9170.American Chemical Society (ACS). doi: 10.1021/jo801735e.

Ueda, M., Walczak, M.A.A., & Wipf, P. (2008). Formal Alder-ene reaction of a bicyclo[1.1.0]butane in the synthesis of the tricyclic quaternary ammonium core of daphniglaucins. TETRAHEDRON LETTERS, 49(41), 5986-5989.Elsevier. doi: 10.1016/j.tetlet.2008.07.179.

Vogt, A., McDonald, P.R., Tamewitz, A., Sikorski, R.P., Wipf, P., Skoko, J.J.I.I.I., & Lazo, J.S. (2008). A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. MOLECULAR CANCER THERAPEUTICS, 7(2), 330-340.American Association for Cancer Research (AACR). doi: 10.1158/1535-7163.MCT-07-2165.

Walczak, M.A.A., & Wipf, P. (2008). Rhodium(I)-catalyzed cycloisomerizations of bicyclobutanes. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(22), 6924-+.American Chemical Society (ACS). doi: 10.1021/ja802906k.

Wipf, P., & Jayasuriya, N. (2008). Chiral ligand optimization in the asymmetric zirconium-zinc transmetalation aldehyde addition reaction. CHIRALITY, 20(3-4), 425-430.Wiley. doi: 10.1002/chir.20468.

Wipf, P., & Maciejewski, J.P. (2008). Titanocene(III)-catalyzed formation of indolines and azaindolines. ORGANIC LETTERS, 10(19), 4383-4386.American Chemical Society (ACS). doi: 10.1021/ol801860s.

Wright, C.M., Chovatiya, R.J., Jameson, N.E., Turner, D.M., Zhu, G., Werner, S., Huryn, D.M., Pipas, J.M., Day, B.W., Wipf, P., & Brodsky, J.L. (2008). Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. BIOORGANIC & MEDICINAL CHEMISTRY, 16(6), 3291-3301.Elsevier. doi: 10.1016/j.bmc.2007.12.014.

Zuber, G., Wipf, P., & Beratan, D.N. (2008). Exploring the optical activity tensor by anisotropic Rayleigh optical activity scattering (vol 9, pg 265, 2008). CHEMPHYSCHEM, 9(4), 504.Wiley. doi: 10.1002/cphc.200890014.

Arnold, D.M., Foster, C., Huryn, D.M., Lazo, J.S., Johnston, P.A., & Wipf, P. (2007). Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors. CHEMICAL BIOLOGY & DRUG DESIGN, 69(1), 23-30.Wiley. doi: 10.1111/j.1747-0285.2007.00474.x.

Brisson, M., Foster, C., Wipf, P., Joo, B., Tomko, R.J.J., Nguyen, T., & Lazo, J.S. (2007). Independent mechanistic inhibition of Cdc25 phosphatases by a natural product caulibugulone. MOLECULAR PHARMACOLOGY, 71(1), 184-192.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/mol.106.028589.

Burnett, J.C., Ruthel, G., Stegmann, C.M., Panchal, R.G., Nguyen, T.L., Hermone, A.R., Stafford, R.G., Lane, D.J., Kenny, T.A., McGrath, C.F., Wipf, P., Stahl, A.M., Schmidt, J.J., Gussio, R., Brunger, A.T., & Bavari, S. (2007). Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons. JOURNAL OF BIOLOGICAL CHEMISTRY, 282(7), 5004-5014.Elsevier. doi: 10.1074/jbc.M608166200.

Guo, J., Parise, R.A., Joseph, E., Lan, J., Pan, S.S., Joo, B., Egorini, M.J., Wipf, P., Lazo, J.S., & Eiseman, J.L. (2007). Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284). ANTICANCER RESEARCH, 27(5A), 3067-3073.Potamitis Press.

Jiang, J., Kurnikov, I., Belikova, N.A., Xiao, J., Zhao, Q., Amoscato, A.A., Braslau, R., Studer, A., Fink, M.P., Greenberger, J.S., Wipf, P., & Kagan, V.E. (2007). Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 320(3), 1050-1060.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/jpet.106.114769.

Kanai, A., Zabbarova, I., Amoscato, A., Epperly, M., Xiao, J., & Wipf, P. (2007). Mitochondrial targeting of radioprotectants using peptidyl conjugates. ORGANIC & BIOMOLECULAR CHEMISTRY, 5(2), 307-309.Royal Society of Chemistry (RSC). doi: 10.1039/b613334g.

Lee, M.R., Raguse, T.L., Schinnerl, M., Pomerantz, W.C., Wang, X., Wipf, P., & Gellman, S.H. (2007). Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in β-peptides. ORGANIC LETTERS, 9(9), 1801-1804.American Chemical Society (ACS). doi: 10.1021/ol070511r.

Macias, C.A., Chiao, J.W., Xiao, J., Arora, D.S., Tyurina, Y.Y., Delude, R.L., Wipf, P., Kagan, V.E., & Fink, M.P. (2007). Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock. ANNALS OF SURGERY, 245(2), 305-314.Wolters Kluwer. doi: 10.1097/01.sla.0000236626.57752.8e.

Mukhopadhyay, P., Zuber, G., Wipf, P., & Beratan, D.N. (2007). Contiribution of a solute's chiral solvent imprint to optical rotation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(34), 6450-6452.Wiley. doi: 10.1002/anie.200702273.

Pierce, J.G., Waller, D.L., & Wipf, P. (2007). Synthesis of functionalized isoindolinones: Addition of in situ generated organoalanes to acyliminium ions. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 692(21), 4618-4629.Elsevier. doi: 10.1016/j.jorganchem.2007.05.035.

Rodina, A., Vilenchik, M., Moulick, K., Aguirre, J., Kim, J., Chiang, A., Litz, J., Clement, C.C., Kang, Y., She, Y., Wu, N., Felts, S., Wipf, P., Massague, J., Jiang, X., Brodsky, J.L., Krystal, G.W., & Chiosis, G. (2007). Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. NATURE CHEMICAL BIOLOGY, 3(8), 498-507.Springer Nature. doi: 10.1038/nchembio.2007.10.

Wakefield, B., Halter, R.J., & Wipf, P. (2007). Synthesis of (±)-thiohalenaquinone by iterative metalations of thiophene. ORGANIC LETTERS, 9(16), 3121-3124.American Chemical Society (ACS). doi: 10.1021/ol071258y.

Waller, D.L., Stephenson, C.R.J., & Wipf, P. (2007). Spiroketals via oxidative rearrangement of enol ethers. ORGANIC & BIOMOLECULAR CHEMISTRY, 5(1), 58-60.Royal Society of Chemistry (RSC). doi: 10.1039/b612992g.

Wang, Z., McPherson, P.A., Raccor, B.S., Balachandran, R., Zhu, G., Day, B.W., Vogt, A., & Wipf, P. (2007). Structure-activity and high-content Imaging analyses of novel tubulysins. CHEMICAL BIOLOGY & DRUG DESIGN, 70(2), 75-86.Wiley. doi: 10.1111/j.1747-0285.2007.00541.x.

Wipf, P., & Wang, Z. (2007). Total synthesis of N14-desacetoxytubulysin H. ORGANIC LETTERS, 9(8), 1605-1607.American Chemical Society (ACS). doi: 10.1021/ol070415q.

Wipf, P., Gong, H., Janjic, J.M., Li, S., Day, B.W., & Xie, W. (2007). New opportunities for pregnane X receptor (PXR) targeting in drug development. Lessons from enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 7(6), 617-625.Bentham Science Publishers. doi: 10.2174/138955707780859404.

Wipf, P., Werner, S., Twining, L.A., & Kendall, C. (2007). HPLC determinations of enantiomeric ratios. CHIRALITY, 19(1), 5-9.Wiley. doi: 10.1002/chir.20331.

Cossy, J., Belotti, D., Brisson, M., Skoko, J.J., Widf, P., & Lazo, J.S. (2006). Biological evaluation of newly synthesized quinoline-5,8-quinones as Cdc25B inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, 14(18), 6283-6287.Elsevier. doi: 10.1016/j.bmc.2006.05.053.

Goldsmith, M.R., George, C.B., Zuber, G., Naaman, R., Waldeck, D.H., Wipf, P., & Beratan, D.N. (2006). The chiroptical signature of achiral metal clusters induced by dissymmetric adsorbates. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 8(1), 63-67.Royal Society of Chemistry (RSC). doi: 10.1039/b511563a.

Lazo, J.S., Nunes, R., Skoko, J.J., de Oliveira, P.E.Q., Vogt, A., & Wipf, P. (2006). Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1. BIOORGANIC & MEDICINAL CHEMISTRY, 14(16), 5643-5650.Elsevier. doi: 10.1016/j.bmc.2006.04.036.

Levinson, N., Hinman, R., Patil, A., Stephenson, C.R.J., Werner, S., Woo, G.H.C., Xiao, J.B., Wipf, P., & Lynch, K.W. (2006). Use of transcriptional synergy to augment sensitivity of a splicing reporter assay. RNA, 12(5), 925-930.Cold Spring Harbor Laboratory. doi: 10.1261/rna.8306.

Powis, G., Wipf, P., Lynch, S.M., Birmingham, A., & Kirkpatrick, D.L. (2006). Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors thioredoxin reductase. MOLECULAR CANCER THERAPEUTICS, 5(3), 630-636.American Association for Cancer Research (AACR). doi: 10.1158/1535-7163.MCT-05-0487.

Werner, S., Turner, D.M., Lyon, M.A., Huryn, D.M., & Wipf, P. (2006). A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process. SYNLETT, 2006(14), 2334-2338.Thieme. doi: 10.1055/s-2006-949648.

Wipf, P., & Furegati, M. (2006). Synthesis of the 3-Aza-[7]-paracyclophane core of Haouamine A and B. ORGANIC LETTERS, 8(9), 1901-1904.American Chemical Society (ACS). doi: 10.1021/ol060455e.

Wipf, P., & Grenon, M. (2006). Toward the total synthesis of lophotoxin - New methodologies and synthetic strategies. CANADIAN JOURNAL OF CHEMISTRY, 84(10), 1226-1241.Canadian Science Publishing. doi: 10.1139/V06-073.

Wipf, P., & Pierce, J.G. (2006). Expedient synthesis of the α-C-glycoside analogue of the immunostimulant galactosylceramide (KRN7000). ORGANIC LETTERS, 8(15), 3375-3378.American Chemical Society (ACS). doi: 10.1021/ol0613057.

Wipf, P., & Walczak, M.A.A. (2006). Pericyclic cascade reactions of (bicyclo[1.1.0]butylmethyl)amines. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 45(25), 4172-4175.Wiley. doi: 10.1002/anie.200600723.

Wipf, P., & Wang, C. (2006). Synthesis and Ag(I) complexation studies of tethered westiellamide. ORGANIC LETTERS, 8(11), 2381-2384.American Chemical Society (ACS). doi: 10.1021/ol060677c.

Wipf, P., Graham, T.H., Vogt, A., Sikorski, R.P., Ducruet, A.P., & Lazo, J.S. (2006). Cellular analysis of disorazole C1 and structure-activity relationship of analogs of the natural product. CHEMICAL BIOLOGY & DRUG DESIGN, 67(1), 66-73.Wiley. doi: 10.1111/j.1747-0285.2005.00313.x.

Woo, G.H.C., Kim, S.H., & Wipf, P. (2006). π-allyl palladium approach toward the diazabicyclo[3.2.1]octane core of the naphthyridinomycin alkaloids. TETRAHEDRON, 62(45), 10507-10517.Elsevier. doi: 10.1016/j.tet.2006.06.114.

Xiao, J., Weisblum, B., & Wipf, P. (2006). Trisubstituted (E)-alkene dipeptide isosteres as β-turn promoters in the gramicidin S cyclodecapeptide scaffold. ORGANIC LETTERS, 8(21), 4731-4734.American Chemical Society (ACS). doi: 10.1021/ol0617704.

Brisson, M., Nguyen, T., Wipf, P., Joo, B., Day, B.W., Skoko, J.S., Schreiber, E.M., Foster, C., Bansal, P., & Lazo, J.S. (2005). Redox regulation of Cdc25B by cell-active quinolinediones. MOLECULAR PHARMACOLOGY, 68(6), 1810-1820.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/mol.105.016360.

Fu, X.L., Moss, R.A., Sauers, R.R., & Wipf, P. (2005). The fragmentation of exo-5-norbornenyl-2-oxychlorocarbene:: stereochemistry and mechanism. TETRAHEDRON LETTERS, 46(24), 4265-4268.Elsevier. doi: 10.1016/j.tetlet.2005.03.208.

Ihle, N.T., Paine-Murrieta, G., Berggren, M.I., Baker, A., Tate, W.R., Wipf, P., Abraham, R.T., Kirkpatrick, D.L., & Powis, G. (2005). The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. MOLECULAR CANCER THERAPEUTICS, 4(9), 1349-1357.American Association for Cancer Research (AACR). doi: 10.1158/1535-7163.MCT-05-0149.

Janjic, J.M., Mu, Y., Kendall, C., Stephenson, C.R.J., Balachandran, R., Raccor, B.S., Lu, Y., Zhu, G.G., Xie, W., Wipf, P., & Day, B.W. (2005). New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides. BIOORGANIC & MEDICINAL CHEMISTRY, 13(1), 157-164.Elsevier. doi: 10.1016/j.bmc.2004.09.048.

Moss, R.A., Fu, X.L., Sauers, R.R., & Wipf, P. (2005). Endo entry to the nortricyclyl-norbornenyl cation system:: Stereochemistry in the fragmentation of endo-5-norbornenyl-2-oxychlorocarbene. JOURNAL OF ORGANIC CHEMISTRY, 70(21), 8454-8460.American Chemical Society (ACS). doi: 10.1021/jo051222o.

Moss, R.A., Fu, X.L., Tian, J.Z., Sauers, R., & Wipf, P. (2005). Stereochemistry of oxachlorocarbene SNi reactions. ORGANIC LETTERS, 7(7), 1371-1374.American Chemical Society (ACS). doi: 10.1021/ol050185k.

Mu, Y., Stephenson, C.R.J., Kendall, C., Saini, S.P.S., Toma, D., Ren, S.R., Cai, H.B., Strom, S.C., Day, B.W., Wipf, P., & Xie, W. (2005). A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development. MOLECULAR PHARMACOLOGY, 68(2), 403-413.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/mol.105.013292.

Nguyen, T.L., McGrath, C., Hermone, A.R., Burnett, J.C., Zaharevitz, D.W., Day, B.W., Wipf, P., Hamel, E., & Gussio, R. (2005). A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. JOURNAL OF MEDICINAL CHEMISTRY, 48(19), 6107-6116.American Chemical Society (ACS). doi: 10.1021/jm050502t.

Wipf, P., & Graham, T.H. (2005). Synthesis and hetero-Michael addition reactions of 2-alkynyl oxazoles and oxazolines. ORGANIC & BIOMOLECULAR CHEMISTRY, 3(1), 31-35.Royal Society of Chemistry (RSC). doi: 10.1039/b413604g.

Wipf, P., & Halter, R.J. (2005). Chemistry and biology of wortmannin. ORGANIC & BIOMOLECULAR CHEMISTRY, 3(11), 2053-2061.Royal Society of Chemistry (RSC). doi: 10.1039/B504418a.

Wipf, P., & Hopkins, T.D. (2005). Total synthesis and structure validation of (+)-bistramide C. CHEMICAL COMMUNICATIONS, 0(27), 3421-3423.Royal Society of Chemistry (RSC). doi: 10.1039/b505100b.

Wipf, P., & Pierce, J.G. (2005). Synthesis of homoallylic arnines by hydrozirconation-imine addition of allenes. ORGANIC LETTERS, 7(16), 3537-3540.American Chemical Society (ACS). doi: 10.1021/ol051266j.

Wipf, P., & Spencer, S.R. (2005). Asymmetric total syntheses of tuberostemonine, didehydrotuberostemonine, and 13-epituberostemonine. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(1), 225-235.American Chemical Society (ACS). doi: 10.1021/ja044280k.

Wipf, P., & Stephenson, C.R.J. (2005). Three-component synthesis of α,β-cyclopropyl-γ-amino acids. ORGANIC LETTERS, 7(6), 1137-1140.American Chemical Society (ACS). doi: 10.1021/ol0501525.

Wipf, P., & Xiao, J.B. (2005). Convergent approach to (E)-alkene and cyclopropane peptide isosteres. ORGANIC LETTERS, 7(1), 103-106.American Chemical Society (ACS). doi: 10.1021/ol0477529.

Wipf, P., Coleman, C.M., Janjic, J.M., Iyer, P.S., Fodor, M.D., Shafer, Y.A., Stephenson, C.R.J., Kendall, C., & Day, B.W. (2005). Microwave-assisted "libraries from libraries" approach toward the synthesis of allyl- and C-cyclopropylalkylamides. JOURNAL OF COMBINATORIAL CHEMISTRY, 7(2), 322-330.American Chemical Society (ACS). doi: 10.1021/cc049842a.

Wipf, P., Fletcher, J.M., & Scarone, L. (2005). Microwave promoted oxazole synthesis: cyclocondensation cascade of oximes and acyl chlorides. TETRAHEDRON LETTERS, 46(33), 5463-5466.Elsevier. doi: 10.1016/j.tetlet.2005.06.063.

Wipf, P., Lynch, S.M., Powis, G., Birmingham, A., & Englund, E.E. (2005). Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system. ORGANIC & BIOMOLECULAR CHEMISTRY, 3(21), 3880-3882.Royal Society of Chemistry (RSC). doi: 10.1039/b510718k.

Wipf, P., Mahler, S.G., & Okumura, K. (2005). Metathesis reactions of pyrazolotriazinones generate dynamic combinatorial libraries. ORGANIC LETTERS, 7(20), 4483-4486.American Chemical Society (ACS). doi: 10.1021/ol051839s.

Wipf, P., Pierce, J.G., & Zhuang, N. (2005). Silver(I)-catalyzed addition of zirconocenes to glycal epoxides.: A new synthesis of α-C-glycosides. ORGANIC LETTERS, 7(3), 483-485.American Chemical Society (ACS). doi: 10.1021/ol0475414.

Wipf, P., Waller, D.L., & Reeves, J.T. (2005). Transition-metal-mediated cascade reactions: The water-accelerated carboalumination-Claisen rearrangement-carbonyl addition reaction. JOURNAL OF ORGANIC CHEMISTRY, 70(20), 8096-8102.American Chemical Society (ACS). doi: 10.1021/jo051211v.

Wipf, P., Werner, S., Woo, G.H.C., Stephenson, C.R.J., Walczak, M.A.A., Coleman, C.M., & Twining, L.A. (2005). Application of divergent multi-component reactions in the synthesis of a library of peptidomimetics based on γ-amino-α,β-cyclopropyl acids. TETRAHEDRON, 61(48), 11488-11500.Elsevier. doi: 10.1016/j.tet.2005.09.016.

Wipf, P., Xiao, J.B., & Geib, S.J. (2005). Imine additions of internal alkynes for the synthesis of trisubstituted (E)-alkene and cyclopropane peptide isosteres. ADVANCED SYNTHESIS & CATALYSIS, 347(11-13), 1605-1613.Wiley. doi: 10.1002/adsc.200505171.

Wipf, P., Xiao, J.B., Jiang, J.F., Belikova, N.A., Tyurin, V.A., Fink, M.P., & Kagan, V.E. (2005). Mitochondrial targeting of selective electron scavengers: Synthesis and biological analysis of hemigramicidin-TEMPO conjugates. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(36), 12460-12461.American Chemical Society (ACS). doi: 10.1021/ja053679l.

Zuber, G., Goldsmith, M.R., Beratan, D.N., & Wipf, P. (2005). Assignment of the absolute configuration of [n]-ladderanes by TD-DFT optical rotation calculations. CHIRALITY, 17(8), 507-510.Wiley. doi: 10.1002/chir.20190.

Zuber, G., Goldsmith, M.R., Hopkins, T.D., Beratan, D.N., & Wipf, P. (2005). Systematic assignment of the configuration of flexible natural products by spectroscopic and computational methods: The bistramide C analysis. ORGANIC LETTERS, 7(23), 5269-5272.American Chemical Society (ACS). doi: 10.1021/ol052154v.

Brisson, M., Nguyen, T., Vogt, A., Yalowich, J., Giorgianni, A., Tobi, D., Bahar, I., Stephenson, C.R.J., Wipf, P., & Lazo, J.S. (2004). Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase. MOLECULAR PHARMACOLOGY, 66(4), 824-833.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/mol.104.001784.

Fewell, S.W., Smith, C.M., Lyon, M.A., Dumitrescu, T.P., Wipf, P., Day, B.W., & Brodsky, J.L. (2004). Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(49), 51131-51140.Elsevier. doi: 10.1074/jbc.M404857200.

Han, Y.S., Shen, H.M., Carr, B.I., Wipf, P., Lazo, J.S., & Pan, S.S. (2004). NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 309(1), 64-70.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/jpet.103.059477.

Ihle, N.T., Williams, R., Chow, S., Chew, W., Berggren, M.I., Paine-Murrieta, G., Minion, D.J., Halter, R.J., Wipf, P., Abraham, R., Kirkpatrick, L., & Powis, G. (2004). Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. MOLECULAR CANCER THERAPEUTICS, 3(7), 763-772.American Association for Cancer Research (AACR). doi: 10.1158/1535-7163.763.3.7.

Oguri, T., Nemoto, K., Bansal, P., Wipf, P., & Lazo, J.S. (2004). Induction of Cdc25B expression by epidermal growth factor and transforming growth factor-α. BIOCHEMICAL PHARMACOLOGY, 68(11), 2221-2227.Elsevier. doi: 10.1016/j.bcp.2004.08.011.

Wipf, P., & Graham, T.H. (2004). Total synthesis of (-)-disorazole C1. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126(47), 15346-15347.American Chemical Society (ACS). doi: 10.1021/ja0443068.

Wipf, P., & Nunes, R.L. (2004). Selective carbon-carbon bond formations with alkenylzirconocenes. TETRAHEDRON, 60(6), 1269-1279.Elsevier. doi: 10.1016/j.tet.2003.12.018.

Wipf, P., Aoyama, Y., & Benedum, T.E. (2004). A practical method for oxazole synthesis by cycloisomerization of propargyl amides. ORGANIC LETTERS, 6(20), 3593-3595.American Chemical Society (ACS). doi: 10.1021/ol0485058.

Wipf, P., Janjic, J., & Stephenson, C.R.J. (2004). Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation-transmetalation-aldimine addition sequence. ORGANIC & BIOMOLECULAR CHEMISTRY, 2(4), 443-445.Royal Society of Chemistry (RSC). doi: 10.1039/b316741k.

Wipf, P., Joo, B., Nguyen, T., & Lazo, J.S. (2004). Synthesis and biological evaluation of caulibugulones A-E. ORGANIC & BIOMOLECULAR CHEMISTRY, 2(15), 2173-2174.Royal Society of Chemistry (RSC). doi: 10.1039/b408184f.

Wipf, P., Lynch, S.M., Birmingham, A., Tamayo, G., Jimènez, A., Campos, N., & Powis, G. (2004). Natural product based inhibitors of the thioredoxin-thioredoxin reductase system. ORGANIC & BIOMOLECULAR CHEMISTRY, 2(11), 1651-1658.Royal Society of Chemistry (RSC). doi: 10.1039/b402431a.

Wipf, P., Minion, D.J., Halter, R.J., Berggren, M.I., Ho, C.B., Chiang, G.G., Kirkpatrick, L., Abraham, R., & Powis, G. (2004). Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin. ORGANIC & BIOMOLECULAR CHEMISTRY, 2(13), 1911-1920.Royal Society of Chemistry (RSC). doi: 10.1039/b405431h.

Wipf, P., Reeves, J.T., & Day, B.W. (2004). Chemistry and biology of curacin A. CURRENT PHARMACEUTICAL DESIGN, 10(12), 1417-1437.Bentham Science Publishers. doi: 10.2174/1381612043384853.

Wipf, P., Stephenson, C.R.J., & Walczak, M.A.A. (2004). Diversity-oriented synthesis of azaspirocycles. ORGANIC LETTERS, 6(17), 3009-3012.American Chemical Society (ACS). doi: 10.1021/ol0487783.

Wipf, P., Takada, T., & Rishel, M.J. (2004). Synthesis of the tubuvaline-tubuphenylalanine (tuv-tup) fragment of tubulysin. ORGANIC LETTERS, 6(22), 4057-4060.American Chemical Society (ACS). doi: 10.1021/ol048252i.

Lazo, J.S., & Wipf, P. (2003). Small molecule regulation of phosphatase-dependent cell signaling pathways. ONCOLOGY RESEARCH, 13(6-10), 347-352.Tech Science Press. doi: 10.3727/096504003108748555.

Vogt, A., Cooley, K.A., Brisson, M., Tarpley, M.G., Wipf, P., & Lazo, J.S. (2003). Cell-active dual specificity phosphatase inhibitors identified by high-content screening. CHEMISTRY & BIOLOGY, 10(8), 733-742.Elsevier. doi: 10.1016/S1074-5521(03)00170-4.

Wipf, P., & Graham, T.H. (2003). Photoactivated tungsten hexacarbonyl-catalyzed conversion of alkynols to glycals. JOURNAL OF ORGANIC CHEMISTRY, 68(23), 8798-8807.American Chemical Society (ACS). doi: 10.1021/jo034813s.

Wipf, P., & Lynch, S.M. (2003). Synthesis of highly oxygenated dinaphthyl ethers via SNAr reactions promoted by Barton's base. ORGANIC LETTERS, 5(7), 1155-1158.American Chemical Society (ACS). doi: 10.1021/ol034286z.

Wipf, P., & Stephenson, C.R.J. (2003). Dimethylzinc-mediated addition of alkenylzirconocenes to α-keto and α-imino esters. ORGANIC LETTERS, 5(14), 2449-2452.American Chemical Society (ACS). doi: 10.1021/ol0347141.

Wipf, P., Jayasuriya, N., & Ribe, S. (2003). On the role of chiral catalysts in the alkenyl zirconocene/zinc addition to aldehydes: A study of ligand loading and asymmetric amplification. CHIRALITY, 15(3), 208-212.Wiley. doi: 10.1002/chir.10176.

Wipf, P., Kendall, C., & Stephenson, C.R.J. (2003). Dimethylzinc-mediated additions of alkenylzirconocenes to aldimines.: New methodologies for allylic amine and C-cyclopropylalkylamine syntheses. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125(3), 761-768.American Chemical Society (ACS). doi: 10.1021/ja028092a.

Wipf, P., Pierce, J.G., & Wang, X.D. (2003). Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions. TETRAHEDRON-ASYMMETRY, 14(22), 3605-3611.Elsevier. doi: 10.1016/j.tetasy.2003.07.022.

Wipf, P., Stephenson, C.R.J., & Okumura, K. (2003). Transition-metal-mediated cascade reactions:: C,C-dicyclopropylmethylamines by way of double C,C-σ-bond insertion into bicyclobutanes. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125(48), 14694-14695.American Chemical Society (ACS). doi: 10.1021/ja038623a.

El Sayed, K.A., Yousaf, M., Hamann, M.T., Avery, M.A., Kelly, M., & Wipf, P. (2002). Microbial and chemical transformation studies of the bioactive marine sesquiterpenes (S)-(+)-curcuphenol and -curcudiol isolated from a deep reef collection of the Jamaican sponge Didiscus oxeata. JOURNAL OF NATURAL PRODUCTS, 65(11), 1547-1553.American Chemical Society (ACS). doi: 10.1021/np020213x.

Lazo, J.S., Nemoto, K., Pestell, K.E., Cooley, K., Southwick, E.C., Mitchell, D.A., Furey, W., Gussio, R., Zaharevitz, D.W., Joo, B., & Wipf, P. (2002). Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. MOLECULAR PHARMACOLOGY, 61(4), 720-728.American Society for Pharmacology & Experimental Therapeutics (ASPET). doi: 10.1124/mol.61.4.720.

Lyon, M.A., Ducruet, A.P., Wipf, P., & Lazo, J.S. (2002). Dual-specificity phosphatases as targets for antineoplastic agents. NATURE REVIEWS DRUG DISCOVERY, 1(12), 961-976.Springer Nature. doi: 10.1038/nrd963.

Vogt, A., Pestell, K.E., Day, B.W., Lazo, J.S., & Wipf, P. (2002). The antisignaling agent SC-ααδ9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)-2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. MOLECULAR CANCER THERAPEUTICS, 1(11), 885-892.American Association for Cancer Research.

Wipf, P., & Kendall, C. (2002). Novel Applications of Alkenyl Zirconocenes. Chemistry - A European Journal, 8(8), 1778-1784.Wiley. doi: 10.1002/1521-3765(20020415)8:8<1778::aid-chem1778>3.0.co;2-h.

Wipf, P., & Reeves, J.T. (2002). A formal total synthesis of leucascandrolide A. CHEMICAL COMMUNICATIONS, 0(18), 2066-2067.Royal Society of Chemistry (RSC). doi: 10.1039/b207383h.

Wipf, P., & Soth, M.J. (2002). Synthesis of the C(1)-C(18) segment of lophotoxin and pukalide.: Control of 2-alkenylfuran (E/Z)-configuration. ORGANIC LETTERS, 4(10), 1787-1790.American Chemical Society (ACS). doi: 10.1021/ol025861m.

Wipf, P., & Wang, X.D. (2002). Parallel synthesis of oxazolines and thiazolines by tandem condensation-cyclodehydration of carboxylic acids with amino alcohols and aminothiols. JOURNAL OF COMBINATORIAL CHEMISTRY, 4(6), 656-660.American Chemical Society (ACS). doi: 10.1021/cc020041m.

Wipf, P., & Wang, X.D. (2002). A new ligand scaffold for catalytic asymmetric alkylzinc additions to aldehydes. ORGANIC LETTERS, 4(7), 1197-1200.American Chemical Society (ACS). doi: 10.1021/ol025600c.

Wipf, P., Hopkins, C.R., Phillips, E.O., & Lazo, J.S. (2002). Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin. TETRAHEDRON, 58(32), 6367-6372.Elsevier. doi: 10.1016/S0040-4020(02)00636-1.

Wipf, P., Nunes, R.L., & Ribe, S. (2002). Water-accelerated organometallic chemistry: Alkyne carboalumination - Sulfinimine addition and asymmetric synthesis of allylic amines. HELVETICA CHIMICA ACTA, 85(10), 3478-3488.Wiley. doi: 10.1002/1522-2675(200210)85:10<3478::AID-HLCA3478>3.0.CO;2-E.

Wipf, P., Rector, S.R., & Takahashi, H. (2002). Total synthesis of (-)-tuberostemonine. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124(50), 14848-14849.American Chemical Society (ACS). doi: 10.1021/ja028603t.

Wipf, P., Reeves, J.T., Balachandran, R., & Day, B.W. (2002). Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A. JOURNAL OF MEDICINAL CHEMISTRY, 45(9), 1901-1917.American Chemical Society (ACS). doi: 10.1021/jm0105171.

Wipf, P., Uto, Y., & Yoshimura, S. (2002). Total synthesis of a stereoisomer of bistramide C and assignment of configuration of the natural product. CHEMISTRY-A EUROPEAN JOURNAL, 8(7), 1670-1681.Wiley. doi: 10.1002/1521-3765(20020402)8:7<1670::AID-CHEM1670>3.0.CO;2-4.

Lazo, J.S., Aslan, D.C., Southwick, E.C., Cooley, K.A., Ducruet, A.P., Joo, B., Vogt, A., & Wipf, P. (2001). Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. JOURNAL OF MEDICINAL CHEMISTRY, 44(24), 4042-4049.American Chemical Society (ACS). doi: 10.1021/jm0102046.

Lazo, J.S., Tamura, K., Vogt, A., Jung, J.K., Rodriguez, S., Balachandran, R., Day, B.W., & Wipf, P. (2001). Antimitotic actions of a novel analog of the fungal metabolite palmarumycine CP1. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 296(2), 364-371.American Society for Pharmacology & Experimental Therapeutics.

Ribe, S., & Wipf, P. (2001). Water-accelerated organic transformations. CHEMICAL COMMUNICATIONS, 0(4), 299-307.Royal Society of Chemistry (RSC). doi: 10.1039/b008252j.

Specht, K.M., Nam, J., Ho, D.M., Berova, N., Kondru, R.K., Beratan, D.N., Wipf, P., Pascal, R.A.J., & Kahne, D. (2001). Determining absolute configuration in flexible molecules: A case study. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 123(37), 8961-8966.American Chemical Society (ACS). doi: 10.1021/ja0104406.

Wipf, P., & Aslan, D.C. (2001). Synthesis of bicyclic ortho esters by epoxy ester rearrangements and study of their ring-opening reactions. JOURNAL OF ORGANIC CHEMISTRY, 66(1), 337-343.American Chemical Society (ACS). doi: 10.1021/jo005665y.

Wipf, P., & Graham, T.H. (2001). Synthesis of the C1′-C11′ segment of leucascandrolide A. JOURNAL OF ORGANIC CHEMISTRY, 66(9), 3242-3245.American Chemical Society (ACS). doi: 10.1021/jo005787q.

Wipf, P., & Hopkins, C.R. (2001). Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine. JOURNAL OF ORGANIC CHEMISTRY, 66(9), 3133-3139.American Chemical Society (ACS). doi: 10.1021/jo015512q.

Wipf, P., & Kendall, C. (2001). Tandem zirconocene homologation-aldimine allylation. ORGANIC LETTERS, 3(17), 2773-2776.American Chemical Society (ACS). doi: 10.1021/ol0163880.

Wipf, P., & Methot, J.L. (2001). Synthetic studies toward diazonamide A. A novel approach for polyoxazole synthesis. ORGANIC LETTERS, 3(9), 1261-1264.American Chemical Society (ACS). doi: 10.1021/ol0157196.

Wipf, P., & Reeves, J.T. (2001). Glycosylation via Cp2ZrCl2/AgClO4-mediated activation of anomeric sulfoxides. JOURNAL OF ORGANIC CHEMISTRY, 66(23), 7910-7914.American Chemical Society (ACS). doi: 10.1021/jo015952h.

Wipf, P., & Ribe, S. (2001). Water-accelerated tandem Claisen rearrangement-catalytic asymmetric carboalumination. ORGANIC LETTERS, 3(10), 1503-1505.American Chemical Society (ACS). doi: 10.1021/ol015816z.

Wipf, P., Aslan, D.C., Southwick, E.C., & Lazo, J.S. (2001). Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11(3), 313-317.Elsevier. doi: 10.1016/S0960-894X(00)00658-2.

Wipf, P., Hopkins, T.D., Jung, J.K., Rodriguez, S., Birmingham, A., Southwick, E.C., Lazo, J.S., & Powis, G. (2001). New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11(19), 2637-2641.Elsevier. doi: 10.1016/S0960-894X(01)00525-X.

Ducruet, A.P., Rice, R.L., Tamura, K., Yokokawa, F., Yokokawa, S., Wipf, P., & Lazo, J.S. (2000). Identification of new Cdc25 dual specificity phosphatase inhibitors in a targeted small molecule array. BIOORGANIC & MEDICINAL CHEMISTRY, 8(6), 1451-1466.Elsevier. doi: 10.1016/S0968-0896(00)00069-9.

Kondru, R.K., Beratan, D.N., Friestad, G.K., Smith, A.B., & Wipf, P. (2000). Chiral action at a distance: Remote substituent effects on the optical activity of calyculins A and B. ORGANIC LETTERS, 2(11), 1509-1512.American Chemical Society (ACS). doi: 10.1021/ol005634p.

Lazo, J.S., & Wipf, P. (2000). Combinatorial chemistry and contemporary pharmacology. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 293(3), 705-709.Wiley. doi: 10.1002/chin.200043259.

Pestell, K.E., Ducruet, A.P., Wipf, P., & Lazo, J.S. (2000). Small molecule inhibitors of dual specificity protein phosphatases. ONCOGENE, 19(56), 6607-6612.Springer Nature. doi: 10.1038/sj.onc.1204084.

Phillips, A.J., Uto, Y., Wipf, P., Reno, M.J., & Williams, D.R. (2000). Synthesis of functionalized oxazolines and oxazoles with DAST and deoxo-fluor. ORGANIC LETTERS, 2(8), 1165-1168.American Chemical Society (ACS). doi: 10.1021/ol005777b.

Ribe, S., Kondru, R.K., Beratan, D.N., & Wipf, P. (2000). Optical rotation computation, total synthesis, and stereochemistry assignment of the marine natural product pitiamide A. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 122(19), 4608-4617.American Chemical Society (ACS). doi: 10.1021/ja9945313.

Vogt, A., Wang, A.S., Johnson, C.S., Fabisiak, J.P., Wipf, P., & Lazo, J.S. (2000). In vivo antitumor activity and induction of insulin-like growth factor-1-resistant apoptosis by SC-ααδ9. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 292(2), 530-537.American Society for Pharmacology & Experimental Therapeutics.

Wipf, P., & Jung, J.K. (2000). Formal total synthesis of (+)-diepoxin σ. JOURNAL OF ORGANIC CHEMISTRY, 65(20), 6319-6337.American Chemical Society (ACS). doi: 10.1021/jo000684t.

Wipf, P., & Methot, J.L. (2000). Total synthesis and stereochemical revision of (+)-aeruginosin 298-A. ORGANIC LETTERS, 2(26), 4213-4216.American Chemical Society (ACS). doi: 10.1021/ol006759x.

Wipf, P., & Ribe, S. (2000). Water/MAO acceleration of the zirconocene-catalyzed asymmetric methylalumination of α-olefins. ORGANIC LETTERS, 2(12), 1713-1716.American Chemical Society (ACS). doi: 10.1021/ol005865w.

Wipf, P., & Uto, Y. (2000). Total synthesis and revision of stereochemistry of the marine metabolite trunkamide A. JOURNAL OF ORGANIC CHEMISTRY, 65(4), 1037-1049.American Chemical Society (ACS). doi: 10.1021/jo9914566.

Wipf, P., Aslan, D.C., Luci, D.K., Southwick, E.C., & Lazo, J.S. (2000). Synthesis and biological evaluation of a targeted library of protein phosphatase inhibitors. BIOTECHNOLOGY AND BIOENGINEERING, 71(1), 58-70.Wiley. doi: 10.1002/(SICI)1097-0290(200024)71:1<58::AID-BIT9>3.0.CO;2-0.

Kondru, R.K., Wipf, P., & Beratan, D.N. (1999). Structural and conformational dependence of optical rotation angles. JOURNAL OF PHYSICAL CHEMISTRY A, 103(33), 6603-6611.American Chemical Society (ACS). doi: 10.1021/jp990697e.

Wipf, P., & Coish, P.D.G. (1999). Total synthesis of (±)-nisamycin. JOURNAL OF ORGANIC CHEMISTRY, 64(14), 5053-5061.American Chemical Society (ACS). doi: 10.1021/jo990413m.

Wipf, P., & Hopkins, C.R. (1999). Efficient synthesis of 1,4-dihydro-2H-isoquinoline-3,5,8-triones via cyclobutene ring expansion. JOURNAL OF ORGANIC CHEMISTRY, 64(18), 6881-6887.American Chemical Society (ACS). doi: 10.1021/jo990089v.

Wipf, P., & Jung, J.K. (1999). Nucleophilic additions to 4,4-disubstituted 2,5-cyclohexadienones: Can dipole effects control facial selectivity?. CHEMICAL REVIEWS, 99(5), 1469-1480.American Chemical Society (ACS). doi: 10.1021/cr9803838.

Wipf, P., & Methot, J.L. (1999). Silver(I)-catalyzed addition of zirconocenes to epoxy esters: A new entry to 1,4-dicarbonyl compounds and pyridazinones. ORGANIC LETTERS, 1(8), 1253-1255.American Chemical Society (ACS). doi: 10.1021/ol990924v.

Wipf, P., & Weiner, W.S. (1999). Enantioselective synthesis and photoracemization studies of (+)-2-cyclopropyl-7,8-dimethoxy-2H-chromene-5-carboxylic acid methyl ester, an advanced intermediate of a dihydrofolate reductase inhibitor. JOURNAL OF ORGANIC CHEMISTRY, 64(14), 5321-5324.American Chemical Society (ACS). doi: 10.1021/jo990352s.

Wipf, P., Tsuchimoto, T., & Takahashi, H. (1999). Synthetic applications of ortho esters. PURE AND APPLIED CHEMISTRY, 71(3), 415-421.De Gruyter. doi: 10.1351/pac199971030415.

Kondru, R.K., Lim, S., Wipf, P., & Beratan, D.N. (1997). Synthetic and model computational studies of molar rotation additivity for interacting chiral centers: A reinvestigation of van't Hoff's principle. CHIRALITY, 9(5-6), 469-477.Wiley. doi: 10.1002/(SICI)1520-636X(1997)9:5/6<469::AID-CHIR13>3.0.CO;2-M.

Rice, R.L., Rusnak, J.M., Yokokawa, F., Yokokawa, S., Messner, D.J., Boynton, A.L., Wipf, P., & Lazo, J.S. (1997). A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation. BIOCHEMISTRY, 36(50), 15965-15974.American Chemical Society (ACS). doi: 10.1021/bi971338h.

Studer, A., Jeger, P., Wipf, P., & Curran, D.P. (1997). Fluorous synthesis: Fluorous protocols for the Ugi and Biginelli multicomponent condensations. JOURNAL OF ORGANIC CHEMISTRY, 62(9), 2917-2924.American Chemical Society (ACS). doi: 10.1021/jo970095w.

Wipf, P., & Coish, P.D.G. (1997). Organozirconocene-mediated polyene synthesis: Preparation of asukamycin and manumycin A side chains. TETRAHEDRON LETTERS, 38(29), 5073-5076.Elsevier. doi: 10.1016/S0040-4039(97)01129-5.

Wipf, P., & Jung, J.K. (1997). Long-range electrostatic effects in synthesis: Dipole-controlled nucleophilic addition to a naphthoquinone acetal in model studies toward diepoxin sigma. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 36(7), 764-767.Wiley. doi: 10.1002/anie.199707641.

Goldstein, D.M., & Wipf, P. (1996). Studies toward the synthesis of Stemona alkaloids; A short synthesis of the tricyclic core of tuberostemonines. TETRAHEDRON LETTERS, 37(6), 739-742.Elsevier. doi: 10.1016/0040-4039(95)02302-X.

Wipf, P., & Fritch, P.C. (1996). Total synthesis and assignment of configuration of lissoclinamide 7. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 118(49), 12358-12367.American Chemical Society (ACS). doi: 10.1021/ja962859f.

Wipf, P., & Jahn, H. (1996). Synthetic applications of organochlorozirconocene complexes. TETRAHEDRON, 52(40), 12853-12910.Elsevier. doi: 10.1016/0040-4020(96)00754-5.

Wipf, P., Li, W.J., Adeyeye, C.M., Rusnak, J.M., & Lazo, J.S. (1996). Synthesis of chemoreversible prodrugs of ara-C with variable time-release profiles. Biological evaluation of their apoptotic activity. BIOORGANIC & MEDICINAL CHEMISTRY, 4(10), 1585-1596.Elsevier. doi: 10.1016/0968-0896(96)00153-8.

WIPF, P., & XU, W.J. (1995). ZIRCONOCENE-CATALYZED CATIONIC DIELS-ALDER REACTIONS. TETRAHEDRON, 51(15), 4551-4562.Elsevier. doi: 10.1016/0040-4020(94)01140-U.

WIPF, P. (1993). TRANSMETALATION REACTIONS IN ORGANOCOPPER CHEMISTRY. SYNTHESIS-STUTTGART, 1993(6), 537-557.Thieme. doi: 10.1055/s-1993-25900.

WIPF, P., & XU, W.J. (1993). SYNTHESIS AND REACTIVITY OF DIOXYCARBENIUM IONS FROM EPOXY ESTERS AND CATIONIC ZIRCONIUM COMPLEXES. JOURNAL OF ORGANIC CHEMISTRY, 58(22), 5880-5882.American Chemical Society (ACS). doi: 10.1021/jo00074a006.