Joshua Woolley

Faculty Mentor: William Wagner

Research:Mr. Woolley's research focuses on thrombogenesis in the setting of mechanical circulatory assist devices, with an emphasis on platelet and leukocyte interactions with ventricular assist devices (VADs) in adult and pediatric applications. In vitro and in vivo biocompatibility characterization of novel materials and coatings at the blood/surface interface in rotary VADs will be performed. Biocompatibility information obtained from this novel material characterization will be used to optimize the design of the pediatric rotary VAD currently being developed at the University of Pittsburgh. Mr. Woolley will also begin evaluating the biocompatibility of adult pulsatile and rotary VADs through measurement of hemostatic and immunological markers in patients at University of Pittsburgh Medical Center. These markers will be correlated with secondary indicators of end organ infarcts, infection and immuno-sensitization. 

Publications:  

• Johnson C, Vandenberghe S, Daly A, Woolley J, Snyder S, Verkaik J, Ye S, Borovetz H, Antaki J, Wearden P, Kameneva M, Wagner W. "Biocompatibility Evaluation of the First Generation PediaFlowTM Pediatric Ventricular Assist Device". Artif Organs35(1): 9-21, 2011 
• Ye S, Johnson C, Woolley J, Murata H, Gamble L, Ishihara K, Wagner W. "Simple surface modification of a titanium alloy with silanated zwitterionic phosphorylcholine or sulfobetaine modifiers to reduce thrombogenicity". Colloids Surf B Biointerfaces79(2): 357-64, 2010 
• Johnson C, Wearden P, Kocyildirim E, Maul T, Woolley J, Ye S, Strickler E, Borovetz H, Wagner W. "Platelet activation in ovines undergoing sham surgery or implant of the second generation PediaFlowTM pediatric ventricular assist device". Artif Organs35(6): 602-13, 2011 
• Woolley J, Johnson C, Jackson G, Kormos R, Wagner W. "The influence of patient pre-implant health on platelet and leukocyte biocompatibility in ventricular assist devices". MIRM Scientific Retreat 2010
• Woolley J, Kormos R, Wagner W. "Platelet and leukocyte biocompatibility of pulsatile and continuous flow ventricular assist devices". MIRM Scientific Retreat 2010
• Johnson C, Snyder T, Woolley J, Wagner W. "Flow cytometric assays for quantifying activated ovine platelets". Artificial Organs32(2): 136-45, 2008 
• Dasse K, Gellman B, Kameneva M, Woolley J, Johnson C, Gempp T, Marks J, Kent S, Koert A, Richardson J, Franklin S, Snyder T, Wearden P, Wagner W, Gilbert R, Borovetz H. "Assessment of hydraulic performance and biocompatibility of a MagLev centrifugal pump system designed for pediatric cardiac or cardiopulmonary support". ASAIO J53(6): 771-7, 2007 
• Ye SH, Johnson CA Jr, Woolley JR, Snyder TA, Gamble LJ, Wagner WR. "Covalent surface modification of a titanium alloy with a phosphorylcholine-containing copolymer for reduced thrombogenicity in cardiovascular devices". Biomed Mater Res A91(1): 18-28, 2009 
• Ye S, Johnson C, Woolley J, Oh H, Gamble L, Ishihara K, Wagner W. "Surface modification of a titanium alloy with a phospholipid polymer prepared by a plasma-induced grafting technique to improve surface thromboresistance". Colloids Surf B Biointerfaces74(10): 96-102, 2009 
• Oh H, Ye S, Johnson C, Woolley J, Federspiel W, Wagner W. "Hemocompatibility assessment of carbonic anhydrase modified hollow fiber membranes for artificial lungs". Artif Organs34(5): 439-42, 2010 
• Maul T, Kocyildirim E, Johnson C, Daly A, Olia S, Woolley J, Snyder S, Bengston S, Kameneva M, Antaki J, Wagner W, Borovetz H, Wearden P, The PediaFlow Consortium. "In vitro and in vivo performance evaluation of the second developmental version of the PediaFlow pediatric ventricular assist device." Cardiovascular Engineering and Technology 2011
• Woolley JR, Jamiolkowski M, Ye SH, Wagner WR. "Assessment of platelet deposition on opaque materials under continuous flow conditions". MIRM Scientific Retreat 2011

Conferences:  

• Gordon Research Conference on Assisted Circulation, Big Sky, MT, USA, 08/2007 
• Gordon Research Conference on Assisted Circulation, Waterville Valley, NH, USA, 09/2009 
• Gordon Research Conference on Assisted Circulation, Waterville Valley, NH, USA, 06/2011 
• ASAIO, San Francisco, CA, USA, 07/2008 
• ASAIO, Dallas, TX, USA, 06/2009 
• ASAIO, Chicago, IL. USA, 6/2013
• BMES National Conference, St. Louis, MO, USA, 10/2008 
• BMES National Conference, Pittsburgh, PA, USA, 10/2009 
• McGowan Institute for Regenerative Medicine Scientific Retreat, Nemacolin, PA, USA, 03/2008 
• McGowan Institute for Regenerative Medicine Scientific Retreat, Nemacolin, PA, USA, 03/2009 
• McGowan Institute for Regenerative Medicine Scientific Retreat, Nemacolin, PA, USA, 03/2010 
• McGowan Institute for Regenerative Medicine Scientific Retreat, Nemacolin, PA, USA, 03/2011 
• Society of Thoracic Surgeons, Los Angeles, CA. USA, 01/2013
• International Society for Heart and Lung Transplantation, Montreal, Canada. 04/2013
• American Association of Thoracic Surgeons, Minneapolis, MN. USA, 05/2013