Danial Sharifikia

Faculty Mentors: Kang Kim and Marc Simon

Research:

Danial’s research is focused on right ventricular (RV) biomechanics in pulmonary hypertension (PH). PH is a disease resulting in increased RV afterload, myocardial hypertrophy and ventricular remodeling. RV failure remains the main cause of mortality for nearly 70% of PH patients. Danial’s work evaluates the effects combined angiotensin receptor-neprilysin inhibition on the biomechanical response of RV myocardium using an experimental model of PH, quantitative histological analysis and nonlinear computational modelling. 

Other ongoing projects include development of a high-frequency ultrasound (HFU) imaging framework to evaluate RV myofiber kinematics under loading and development of structurally-informed computational models of RV myocardium.

Publications:

• K. Durney, D. Sharifi Kia, T. Wang, A. Singh, L. Kabowski,H. Koo, G. Ateshian, M. Albro, “Physiologic Medium Maintains the Homeostasis of Immature Bovine Articular Cartilage Explants in Long-Term Culture”, Journal of Biomechanical Engineering, 2019 (DOI: 10.1115/1.4041901).
• D. Sharifi Kia, R. Willing, "Applying a Hybrid Experimental-Computational Technique to Study Elbow Joint Ligamentous Stabilizers", Journal of Biomechanical Engineering, 2018 (DOI: 10.1115/1.4039674).
• D. Sharifi Kia, R. Willing, "Development of a Computational/Experimental Framework for Evaluation of Damage Mechanisms of a Linked Semi-Constrained Total Elbow System", Journal of Shoulder and Elbow Surgery, 2018 (DOI: j.jse.2017.10.020).
• MEI. Shahverdi, S. Nakhodchi, D. Sharifi Kia, " Fatigue life prediction and stress distribution of straight and angled abutments using numerical techniques", Biomedical Physics & Engineering Express, 2018 (DOI: 10.1088/2057-1976/aab18d).
• D. Sharifi Kia, M. Salem, G. Fradet, H. Mohammadi, "Design and Fabrication of a 3D Scaffold for the Aortic Root Tissue Engineering Application", Journal of Medical and Biological Engineering, 2017 (DOI: 10.1007/s40846-017-0290-9).
• D. Sharifi Kia, M. Asgari, "Dynamic Analysis of Healthy and Edge-to-Edge repaired Mitral Valve Behaviour Subjected to High G Accelerations", Journal of Mechanics in Medicine and Biology, 2017 (DOI: 10.1142/S0219519417500324)
• C. Jin, D. Sharifi Kia, M. Jones, S. Towfighian, “On the Contact Behavior of Micro-/Nano-Structured Interface Used in Vertical-Contact-Mode Triboelectric Nanogenerators", Nano Energy, 2016 (DOI: 10.1016/j.nanoen.2016.06.049)

Presentations:

• D. Sharifi Kia, C. Tushak, E. Benza, K. Kim, M. Simon, "Analyzing the biomechanical response of failing right ventricular tissue to Sacubitril-Valsartan treatment", 2019 ASME Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C), June 2019, Seven Springs, PA.
• D. Sharifi Kia, M. Simon, K. Kim, "Towards an ultrasound imaging framework for transmural evaluation of RV fiber orientation", 2019 ASME Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C), June 2019, Seven Springs, PA.
• S. Dogru, D. Sharifi Kia, S. Sze, M. Albro, "Concentration Dependent TGF-beta Internalization Rate In Engineered Musculoskeletal Tissues", 2019 ASME Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C), June 2019, Seven Springs, PA.
• T. Wang, D. Sharifi Kia, S. Baeyens, M. Albro, " Localization of delivery of moderated, near-physiologic levels of active TGF-beta can produce engineered cartilage of improved tissue quality", 2018 World Congress of Biomechanics, July 2018, Dublin, Ireland.
• D. Sharifi Kia, R. Willing, "In Vitro Characterization of Elbow Soft Tissue Constraint to Design Virtual Ligament Models", 2018 Canadian Orthopedic Association Annual Meeting, June 2018, Victoria, British Columbia, Canada.
• D. Sharifi Kia, R. Willing, " Measuring Soft Tissue Contributions to Elbow Joint Motion and Virtual Ligament Modelling: An In-Vitro Study", 64th Orthopedic Research Society (ORS) Annual Meeting, Mar 2018, New Orleans, Louisiana.
• D. Sharifi Kia, R. Willing, "Calibrating a Computational Framework for Determining Wear Rates of Total Elbow Replacement Implants", 63rd Orthopedic Research Society (ORS) Annual Meeting, Mar 2017, San Diego, California.
• D. Sharifi Kia, R. Willing, "Elasto-Plastic Computational Modelling of Damage Mechanisms in Total Elbow Replacements", 29th International Society for Technology in Arthroplasty (ISTA) Congress, Oct 2016, Boston, Massachusetts.
• D. Sharifi Kia, S. Towfighian, C. Jin, “Predicting the Output of a Triboelectric Energy Harvester Undergoing Mechanical Pressure ", ASME 2016 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS), Sep 2016, Stowe, Vermont.
• D. Sharifi Kia, R. Willing, "Examining the Durability of Total Elbow Arthroplasty (TEA) Using Computational and Experimental Techniques", 42nd Annual Northeast Bioengineering Conference, Apr 2016, Binghamton, New York.
• D. Sharifi Kia, R. Willing, "An Explicit Finite Element Model of Total Elbow Replacement Contact Mechanics", 62nd Orthopedic Research Society (ORS) Annual Meeting, Mar 2016, Orlando, Florida.
• D. Sharifi Kia, M. Asgari, "Healthy and Edge-to-Edge repaired Mitral Valve Dynamic Simulation", 2nd Conference on Novel Approaches of Biomedical Engineering in Cardiovascular Diseases, Jan 2016, Tehran, Iran.
• D. Sharifi Kia, M. Asgari, "Explicit dynamic analysis of Mitral valve closure using Hyperelastic constitutive modeling", 23rd International conference on Mechanical Engineering (ISME), Apr 2015, Tehran, Iran.
• D. Sharifi Kia, M. Asgari, "Structural Simulation of Human Mitral Valve Behaviour Considering Effects of Material Nonlinearities", 21th Iranian Conference on Biomedical Engineering (ICBME), Nov 2014, Tehran, Iran. (DOI: 10.1109/ICBME.2014.7043886)

Honors and Awards:

• Boston University College of Engineering Dean’s Fellowship Award, March 2017.
• AMTI Force and Motion Foundation Travel Scholarship, Oct 2016 and Jan 2018.
• Tuition Scholarship Award, State University of New York at Binghamton, Aug 2015-May 2017.
• Ranked 1st in a class of 130, Department of Mechanical Engineering, K. N. Toosi University of Technology, 2011 and 2012.

Mr. Sharifikia’s research is focused on right ventricular (RV) biomechanics in pulmonary hypertension (PH).