Devin Nelson

Faculty Mentor: Mentor Name

Research: Mr. Nelson's research is aimed at optimizing thermoresponsive hydrogels based on N-isopropylacrylamide that can be used for injection into injured myocardium. Currently his work focuses on turning this material into a suitable one for drug delivery upon injection. He is looking at forming polymer-protein conjugates to delay the diffusion of protein from the polymer scaffold. He studies the release profiles of the protein related to the material composition and environment. Future work will involve combining both drugs and cells with the scaffold to make a more functional tissue engineering product.  

Publications:  

• Stehlik J, Nelson DM, Kfoury AG, Reid BB, Clayson SE, Nelson KE, Christensen BJ, Renlund DG, Movsesian MA, Cowley CG, Smith HK, Rasmusson BY, Long JW. "Outcome of noncardiac surgery in patients with ventricular assist devices". The American Journal of Cardiology103(5)(709-12): , 2009 
• Fujimoto, KL, Ma Z, Nelson DM, Hashizume R, Guan J, Tobita K, Wagner WR. "Synthesis, characterization and therapeutic efficacy of a biodegradable, thermoresponsive hydrogel designed for application in chronic infarcted myocardium ". Biomaterials30(26)(4357-68): , 2009 
• Nelson DM, Ma Z, Fujimoto KL, Wagner WR. "Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges". Acta Biomaterialia7(1): 1-15, 2011 
• Ma Z, He W, Nelson DM, Guan J, Wagner WR. "Developing injectable and bioabsorbable thermally responsive hydrogels: synthesis of poly(NIPAAm-co-Aac-co-HEMA-PTMC) and poly(NIPAAm-co-HEMA-co-MA-PLA)". Tissue Engineering and Regenerative Medicine International Society (TERMIS)2008( ): , 2008 
• Fujimoto KL, Ma Z, Nelson DM, Hashizume R, Guan J, Tobita K, Wagner WR. "A biodegradable, thermoresponsive hydrogel designed for application in chronic myocardial infarcts: synthesis, characterization and therapeutic efficacy". 2nd Tissue Engineering and Regenerative Medicine Society (TERMIS)2009( ): , 2009 
• Nelson DM, Baraniak PR, Leeson CE, Wagner WR. "Prolonged controlled release of a gene inducer as a means to spatially-control gene expression in a cellularized scaffold". Society for Biomaterials Annual Conference2010( ): , 2010 
• Nelson DM, Ma Z, Fujimoto KL, Wagner WR. "Modification of an injectable, biodegradable polymer for sustained local protein delivery". Society for Biomaterials Annual Conference2010( ): , 2010 
• Nelson DM, Baraniak PR, Leeson CE, Katakam AK, Friz JL, Cress, DE, Hong Y, Guan J, Wagner WR. "Spatial control of gene expression within a scaffold by localized inducer release". Biomaterials2011( ): , 2011 

Conferences:  

• Society for Biomaterials Annual Conference, Seattle, WA, United States of America, 04/2010
• European Society for Artificial Organs Winter School, Semmering, N/A, Austria, 01/2011