Daniel Crompton

Faculty Mentor: Marina V. Kameneva

Research:

Mr. Crompton’s work in the Hemorheology, Hemodynamics, and Artificial Blood Lab revolves around the study of blood flow within the microcirculation and potential rheological treatments that may lead to the improvement of pathological conditions such as sickle cell disease (SCD) or other chronic inflammatory disorders. Specifically, he is interested in how the addition of nanomolar concentrations of drag-reducing polymers (DRPs) modulate both rigid and deformable blood cell traffic in bifurcating microchannels and microvessels, and has shown that DRPs reduce the number of less deformable cells entering vessel branches which may lead to a potential rheological treatment method for those suffering from SCD, improve brain circulation or reduce inflammation in numerous diseases. Additionally, he is working on a potential SCD treatment using a method of intracellular hemoglobin replacement which would inhibit the ability of RBCs to sickle and reduce the possibility of alloimmunization caused by chronic blood transfusions. Finally, Mr. Crompton is currently working to develop standardized preparation and characterization techniques for DRPs for their future clinical applications and commercialization as well as the development and testing of a miniature pediatric ventricular assist device.

Selected Presentations:

• Crompton D, Orizondo RA, Kameneva MV. Drag Reducing Polymers Improve Oxygen Transfer Rate In Miniature Hollow Fiber Membrane Oxygenators. ASAIO 65th Annual Conference. San Francisco, CA, June 26-29, 2019. Podium Presentation.
• Crompton, D. Intracellular Hemoglobin Replacement of Sickle Erythrocytes. Bridgeside Research Forum, University of Pittsburgh, Pittsburgh PA, November 30, 2018.
• Crompton D, Gudla S, Jimenez MA, Sundd P, Waters J, Kameneva MV. Potential Rheological Treatment of Sickle Cell Disease (SCD) by reducing vaso-occlusion in small vessels. McGowan Institute for Regenerative Medicine Scientific Retreat, Pittsburgh PA, March 5-6, 2018. Rapid Fire Talk and Poster Presentation.
• Crompton D, Gudla S, Maritza J, Sundd P, Kameneva, MV. Drag reducing polymers (DRPs) reduce rigid red blood cell traffic in bifurcating microchannel blood flow. The Society for Rheology 89th Annual Meeting. Denver, CO, October 8-12, 2017. Poster Presentation.
• Wearden PD, Sndyer TA, Stanfield JR, Coghill PA, Wu J, Crompton D, Olia SE, Ye S, Madan S, Kameneva MV, Wagner WR, Long JW. Progress in the Development of a Miniature, Hemocompatible, Continuous Flow Ventricular Assist Device for Infants and Children. ASAIO 63rd Annual Conference. Chicago, IL, June 21-24, 2017. Podium Presentation.
• Crompton D, Gudla S, Jimenez MA, Sundd P, Kameneva MV. Drag-reducing Polymers for the Shunting of Rigid Erythrocytes Past Microvessel Bifurcations: a Potential Treatment for Sickle Cell Disease (SCD). ASAIO 63rd Annual Conference. Chicago, IL, June 21-24, 2017. Poster Presentation.
• Wearden PD, Snyder TA, Stanfield JR, Coghill P, Crompton D, Olia SE, Ye S, Kameneva MV, Wagner WR, Long JW. Development of Miniature, Implantable Pediatric Ventricular Assist Device. International Society for Heart and Lung Transplantation (ISHLT) 2017, San Diego, CA, April 5-8 2017.
• Wearden PD, Snyder TA, Wampler RK, Stanfield JR, Coghill PA, Wu J, Crompton D, Olia SE, Shankarraman V, Maul TJ, Madan S, Kameneva MV, Wagner WR, Long JW. A Novel, Miniature Implantable Continuous Flow Pediatric Ventricular Assist Device. ASAIO 62nd Annual Conference. San Francisco, CA, June 24-27, 2016. Podium Presentation.

 

 

Mr. Crompton’s work revolves around how the addition of nanomolar concentrations of drag reducing polymers (DRPs) modulate both rigid and deformable blood cell traffic in bifurcating microchannels and microvessels.