Lisa Carey

Faculty Mentor: Stephen Badylak

Research:  The most important factor in determining the success of a medical device in vivo is the host immune response; however this has not been extensively studied with cardiovascular biomaterials. Additionally, both acute myocardial infarction and chronic cardiomyopathy require treatment modalities to provide mechanical support as well as induce positive tissue remodeling. New devices composed of biologically derived extracellular matrix (ECM) provide options for inducing a favorable host tissue remodeling response for treating cardiovascular indications, but few studies have been done comparing such materials to the most commonly used synthetic materials. My work will evaluate the immune response and tissue remodeling outcomes for several commercially available and novel cardiovascular biomaterials. 

Publications:    

• Wolf MT, Carruthers CA, Dearth CL, Crapo PM, Huber A, Burnsed OA, Londono R, Johnson SA, Daly KA, Stahl EC, Freund JM, Medberry CJ, Carey LE, Nieponice A, Amoroso NJ, Badylak SF. "Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response."  J Biomed Mater Res A. 2013. 

Conferences:    

• TERMIS North America, 12/11/2011
• AFIRM, 2/13/2012
• AFIRM Workshop in Enabling Technologies, 2/4/2013
• ARM IV & V Postdoctoral Research Review Meeting, Pittsburgh, PA, 12/19/2012
• McGowan Institute for Regenerative Medicine Scientific Retreat, Nemacolin, PA, USA, 3/7/2013

 

Lisa's research interests are focused on limb regeneration in response to controlled delivery of extracellular matrix (ECM) products, as well as the role of immune response in tissue remodeling.