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Biosensor for neurochemicals

Biosensor for neurochemicals

Real-time analysis of biochemical signals holds immense potential for advancing both our comprehension of biology and our diagnostic capabilities. Our efforts have focused on two distinct sensor types.

The first employs electrochemical measurement techniques to detect electroactive molecules, such as dopamine, serotonin, hydrogen peroxide, and melatonin, leveraging their specific redox responses. We've dedicated ourselves to enhancing these sensors by refining electrode materials and measurement techniques to enhance sensitivity and longevity. Utilizing nanomaterials like graphene and carbon nanotubes (CNTs), alongside conducting polymers, we've notably boosted the sensitivity of carbon electrodes in dopamine and serotonin sensing through Fast Scan Cyclic Voltammetry (FSCV).

Moreover, employing optimized square wave voltammetry (SWV) in tandem with the highly sensitive PEDOT/CNT has enabled basal dopamine sensing across multiple brain sites. By pairing these techniques with flexible microfabricated glassy carbon microelectrode arrays, we have enabled high-throughput manufacturing of multichannel carbon sensors, something that has previously been a tedious, manual process. 

The second sensor type incorporates biorecognition elements such as enzymes or aptamers, delivering high specificity, sensitivity, and rapid response times in detecting glutamate, GABA, cocaine, and various cytokines that are not inherently electroactive. These innovative sensors are poised to be pivotal in advancing neuroscience research and facilitating real-time, continuous, point-of-care diagnostics.

Relevant Publications: