Projects 

  

  

Extracellular Matrix TMJ Disc Device 

In collaboration with the Badylak lab, we are currently testing the in vivo regeneration potential of TMJ disc scaffolds derived from porcine urinary bladder matrix in a canine model.   In a pilot study, after six months, the morphology of the remodeled UBM scaffold resembles that of the native TMJ disc. 


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Biodegradable Magnesium Condyle 

As part of the NSF-funded ERC initiative we are working towards creating a biodegradable magnesium  condylar prosthetic for the TMJ.  As a first step, we have assessed the in vivo degradation of magnesium screws in a rabbit model.   

In order to test the effect of magnesium on the fibrocartilage of the TMJ disc and mandibular condylar cartilage, we have also been testing the in vitro biocompatibility of goat costal chondrocytes in media containing high concentrations of magnesium.      


 

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Pain, Kinematics, and Mechanical Properties 

We are using a splint-induced malocclusion model of TMD pain where we combine information from dual x-ray and μ-CT to assess 3D Bone Positions. In the process, we propose to validate a non-invasive technique for imaging TMJ arthrokinematics as a means of assessing the development of joint hypersensitivity.  


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Polymer Bone Scaffold 

We are investigating the application of the elastomeric material Poly (glycerol Sebacate) (PGS) for bone engineering. The material superiority regards its load-transduction to osteogenic cells, steady biodegradability and the ability of application in non-uniformly loaded defects such as craniofacial osteo/chondro defects.  


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About Us 

 The TMJ labs are part of the Center for Craniofacial Regeneration (CCR). The CCR is based at the University of Pittsburgh School of Dental Medicine and the McGowan Institute for Regenerative Medicine, a program of the University of Pittsburgh and the University of Pittsburgh Medical Center The Center for Craniofacial Regeneration is comprised of a diverse team of clinicians, basic scientists, and clinical researchers.   

  

Contact Information 

TMJ Laboratories  

502 Salk Hall  

3501 Terrace Street  

Pittsburgh, PA 15261  

Phone: (412) 648-3101  

Fax: (412) 624-6685  


Important Links

Center for Craniofacial Regeneration

Department of Bioengineering

McGowen Institute for Regenerative Medicine

Musculoskeletal Research Center