Extracellular Matrix TMJ Disc Device
In collaboration with the Badylak lab, we are currently testing the in
vivo regeneration potential of TMJ disc scaffolds derived from porcine
urinary bladder matrix in a canine model.
In a pilot study, after six months, the morphology of the remodeled UBM
scaffold resembles that of the native TMJ disc.
Biodegradable Magnesium Condyle
As part of the NSF-funded ERC initiative we are working towards
creating a biodegradable magnesium
condylar prosthetic for the TMJ.
As a first step, we have assessed the in vivo degradation of
magnesium screws in a rabbit model.
In order to test the effect of magnesium on the fibrocartilage of the
TMJ disc and mandibular condylar cartilage, we have also been testing the in
vitro biocompatibility of goat costal chondrocytes in media containing high
concentrations of magnesium.
Pain, Kinematics, and Mechanical Properties
We are using a splint-induced malocclusion model of TMD pain where we
combine information from dual x-ray and μ-CT to
assess 3D Bone Positions. In the process, we propose to validate a non-invasive
technique for imaging TMJ arthrokinematics as a means of assessing the
development of joint hypersensitivity.
Polymer Bone Scaffold
We are investigating the application of the elastomeric material Poly
(glycerol Sebacate) (PGS) for bone engineering. The material superiority
regards its load-transduction to osteogenic cells, steady biodegradability and
the ability of application in non-uniformly loaded defects such as craniofacial
TMJ labs are part of the Center for Craniofacial Regeneration (CCR). The CCR is
based at the University of Pittsburgh School of Dental Medicine and the McGowan
Institute for Regenerative Medicine, a program of the University of Pittsburgh
and the University of Pittsburgh Medical Center The Center for Craniofacial
Regeneration is comprised of a diverse team of clinicians, basic scientists,
and clinical researchers.
Phone: (412) 648-3101
Fax: (412) 624-6685